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BCA Assay and Lowry Assays | Thermo Fisher Scientific - PH

BCA Assay and Lowry Assays | Thermo Fisher Scientific - PH

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Home›Life Sciences›Protein Biology›Protein Assays and Analysis›Protein Assays›BCA Assay and Lowry AssaysBCA Assay and Lowry AssaysSee Navigation‹Protein AssaysFluorescent Protein Assays

›Class-Specific Protein Quantitation

›Amino Acid Analysis Reagents

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›BCA Assay and Lowry Assays

›Bradford Assay

Copper-based total protein quantification

The BCA Protein Assay is a popular method for colorimetric detection and quantitation of total protein. Pierce BCA Protein Assays have a unique advantage over the Coomassie dye–based assays (Bradford)–they are compatible with samples that contain up to 5% surfactants (detergents), and are affected much less by protein compositional differences, providing greater protein-to-protein uniformity.For added ease of use, BCA protein assays with dilution-free protein standards reduces assay setup time by up to 80%. Dilution-Free protein standards are a set of prediluted standards packaged in a multichannel pipette compatible format which allows you to easily transfer a full dilution series to your microplate at once.Selection guide   Technical handbookOn this page:Choose the right BCA assay for your sampleBCA assay principlesDilution-Free BCA protein assaysAdvantages of BCA assaysBCA protein assay protocolsRelated content:Bradford assays

Choose the right BCA protein assay for your sample

BCA assaysLowry assaysOrderingDocuments  Pierce Dilution-Free Rapid Gold BCA Protein AssayPierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsPierce BCA Protein Assay - Reducing Agent CompatibleMicro BCA Protein AssayAssay range: (sample volume)20–10,000 µg (10 µL)20–2,000 µg/mL (25 µL)125–2,000 µg/mL (9 µL)2–40 µg/mL (150 µL) or 0.5–20 µg/mL (500 µL)Incubation time and temperature5 min at RT30 min at 37°C45 min at 37°C60 min at 60°CTotal assay time10 min45 min115 min130 minAbsorbance480 nm562 nm562 nm562 nmCompatible reagentsDetergentsDetergentsDetergents/reducing agents (e.g. DTT)DetergentsIncompatible reagentsReducing agents; chelatorsReducing agents; chelatorsChelatorsReducing agents; chelatorsUniformityLess protein: protein variation than Bradford assaysLess protein: protein variation than Bradford assaysSignificantly less (14–23%) protein: protein variation than Bradford assaysLess protein: protein variation than Bradford assaysDilution-free protein standardsYesYesNoNoCat. No.A55860 (500 mL)A55861 (250 mL)A55862 (20 mL)A55864 (1000 mL)A55865 (500 mL) Related BCA Kits:23225 (1000 mL)23227 (500 mL)23250 (275 mL/kit)23252 (microplate)23235 (500 mL/kit)Related product: Pierce Dilution Free BSA Protein Standards, Multichannel Pipette Compatible, 0.125–2 mg/mLRelated product: Pierce Dilution-Free BSA Protein Standards, Multichannel Pipette Compatible, 0.125–10 mg/mLBCA kits overviewDilution-Free Rapid Gold BCA Protein Assay – green to yellow (A480 nm), 2-component, precise, detergent compatible assay to measure total protein vs. protein standard in 5 minutes at room temperatureBCA Protein Assay with Dilution-Free BSA Protein Standards – green-to-purple (A562 nm), 2-component, precise, detergent-compatible assay reagent to measure total protein concentration vs. protein standard in 30 minutes at 37°C.BCA Protein Assay - Reducing Agent Compatible – reducing agent–compatible version of our BCA Reagent Kit to measure protein concentration in samples containing DTT or BME thiol-reductants.Micro BCA Protein Assay – special 3-component version of our BCA Reagent Kit to measure total protein concentration of dilute protein solutions (0.5 to 20 μg/mL).Effortless, Fast, AccurateSelect BCA assays now include Dilution-Free BSA Protein Standards which are a set of 7 prediluted BSA standards, uniquely designed for multichannel pipette compatibility.Pierce Dilution-Free standards allow you to eliminate time-consuming and tedious dilutions when generating your standard curve and are calibrated by direct comparison to purified BSA from the National Institute of Standards and Technology (NIST) to help ensure accurate standard curve generation.

BCA assay principles

Chemistry of BCA-based protein assaysThe Pierce BCA Protein Assays combines the well-known reduction of Cu2+ to Cu+ by protein in an alkaline medium (also known as the biuret reaction) with the highly sensitive and selective colorimetric detection of the cuprous cation (Cu+) by bicinchoninic acid (BCA).Figure 1. The first step is the chelation of copper with protein in an alkaline environment to form a blue-colored complex. In this reaction, peptides containing three or more amino acid residues form a colored chelate complex with cupric ions in an alkaline environment containing sodium potassium tartrate.Single amino acids and dipeptides are unaffected in the biuret reaction, but tripeptides and larger polypeptides or proteins will react to produce the light blue-to-violet complex that absorbs light at 540 nm. One cupric ion forms a colored coordination complex with four to six nearby peptides bonds. The intensity of the color produced is proportional to the number of peptide bonds participating in the reaction.Figure 2. In the second step, BCA reagent, a highly sensitive and selective colorimetric detection reagent, reacts with the cuprous cation (Cu+) that was formed in the first step and produces a purple-color.The BCA-copper complex is water-soluble and exhibits a strong linear absorbance at 562 nm with increasing protein concentrations. The purple color may be measured at any wavelength between 550 and 570 nm with minimal (less than 10%) loss of signal. The signal induced by the BCA reagent is approximately 100 times more sensitive (lower limit of detection) than the signal using the biuret reagent.Pierce Dilution-Free Rapid Gold BCA protein assay uses the same copper reduction method as traditional BCA assay with a unique copper chelator. In the second step of the color development reaction, the Pierce Dilution-Free Rapid Gold BCA chelator reacts with the reduced (cuprous) cation (Cu+) that was formed in step one to produce an intensely gold-colored reaction product. The copper complex exhibits a strong linear absorbance at 480 nm with increasing protein concentrations.

Dilution-free BCA protein assays

Dilution-free BSA protein standards are available separately or as part of other BCA protein assays. Compared to the Bradford Assay or Pierce BCA Protein assay kit, the Dilution-Free Rapid Gold BCA Protein Assay reduces assay setup by up to 80% by eliminating the need to dilute samples and standards. Additionally, it only requires a 5-minute, room temperature incubation. The dilution-free BSA protein standards are also available in the BCA Protein Assay Kit with Dilution-Free BSA Protein Standards.Figure 3. The Pierce Dilution-Free Rapid Gold BCA Assay reduces setup time by up to 80% compared to other protein assays. The assays were conducted following the manufacturer’s protocols in a microplate format. Five cell lysates and five pure proteins were prepared to give a total of ten samples. Standard curves for the BCA and Bradford assays were generated through serial dilution of 2 mg/mL bovine serum albumin (BSA) standard. The standard curve for the Pierce Dilution-Free Rapid Gold BCA Assay was generated using Pierce Dilution-Free BSA Protein Standards (included with the kit) packaged in a multichannel pipette-friendly tube strip. Four of the ten samples were expected to have a starting concentration of >2 mg/mL, which necessitated a sample dilution step for the BCA and Bradford assays, whereas samples were not required to be diluted for the Dilution-Free Rapid Gold BCA Assay. Samples were then mixed with working reagent from each assay and incubated according to the manufacturer’s instructions.

Advantages of BCA assays

BCA protein quantificationOne of the major advantages of the BCA assay is that it produces a linear response curve. This response curve allows accurate determination of unknown protein concentrations and provides a higher dynamic range than other standard assays.Figure 4. Pierce Dilution-Free Rapid Gold BCA Protein Assay generates a linear standard curve across a wide dynamic range (0–10 mg/mL). Standard curves were produced for the Pierce Dilution-Free Rapid Gold BCA Protein Assay and the Quick Start Bradford Protein Assay (Bio-Rad) with purified BSA in 0.9% saline (0–10 mg/mL). Both assays were conducted using the manufacturer’s protocols in a microplate format. Absorbance readings were taken using the Thermo Scientific Varioskan LUX Multimode Microplate Reader.

BCA assay accuracy

Another major advantage of BCA protein assays is the accuracy as shown through low protein-to-protein variation. Proteins are diverse in their composition and structure, and with some assays, the proteins’ differences in amino acid sequence, isoelectric point (pI), secondary structure, and side chains or prosthetic groups result in variation in the colorimetric response. Since BCA chemistries develop a color response in proportion to the number of peptide bonds present, they are less affected by these differences when compared to dye-binding assays (e.g. Bradford Assays) and therefore exhibit less protein-to-protein variation.Figure 5. Protein quantification results of the Pierce Dilution-Free Rapid Gold BCA Protein Assay and the Quick Start Bradford Protein Assay compared to samples of known concentration. Both assays were conducted in a microplate format, according to the respective manufacturers’ protocols. For the Bradford assay, 5 μL of sample was added to 250 μL of the Bradford working reagent and incubated at room temperature for 5 minutes. For the Dilution-Free Rapid Gold BCA Protein Assay, 10 μL of sample was added to 200 μL of Dilution-Free Rapid Gold BCA working reagent and incubated at room temperature for 5 minutes. Known concentrations of protein samples were based on manufacturers’ indicated concentrations and were confirmed by absorbance at 280 nm.

BCA protein assay protocols

BCA Protein Assay with Dilution-Free BSA Protein StandardsThe Pierce BCA Protein Assay can be performed using two different formats based upon the dynamic range needed to detect the protein concentration of an unknown sample. This BCA assay detects protein concentrations from 20–2,000 μg/mL using a two-component system: Reagent A, a carbonate buffer containing BCA reagent, and Reagent B, a cupric sulfate solution, which are combined to make an apple green–colored working solution that turns purple after 30 minutes at 37°C in the presence of protein. Since the color reaction is not a true endpoint reaction, considerable protocol flexibility is allowed with the Pierce BCA Protein Assay. By increasing the incubation temperature, the sensitivity of the assay can be increased. When using the enhanced tube protocol (i.e., incubating at 60°C for 30 minutes), the working range for the assay shifts to 5–250 μg/mL, facilitating detection of more dilute samples.Figure 6. BCA Protein Assay Kit with Dilution-Free BSA Protein Standards, multichannel pipe compatible protocol.Dilution-Free Rapid Gold BCA Protein Assay Kit protocolThe Dilution-Free Rapid Gold BCA Protein Assay provides the high sensitivity and linearity associated with the BCA assay but performed within a fraction of the time. Simply mix the BCA working solution, add samples and dilution-free standards to your microplate, incubate for 5 minutes at room temperature, and read the absorbance.Figure 7. Dilution-Free Rapid Gold BCA Protein Assay Kit protocol.Modified Lowry Protein Assay KitAssay range: microplate (sample volume)10 to 1,500 µg/mL (40 µL)Assay range: cuvette (sample volume)1–1,500 µg/mL (200 µL)Incubation time and temperature10 and 30 min at RTTotal assay time110 minAbsorbance750 nmCompatible reagentsSDS (up to 1%)Incompatible reagentsReducing reagents, Chelators, detergents, tris, tricine, glycerolUniformityLess protein:protein variation than Coomassie dye methodsProduct size530 mL/kitCat. No.23240Related product: Pierce Dilution Free BSA Protein Standards, Multichannel Pipette Compatible, 2 mg/mLLowry assay principlesThe Pierce Modified Lowry Protein Assay is based on the colorimetric method introduced by Oliver H. Lowry in 1951. The Pierce modified assay replaces two of the assay’s traditional unstable reagents with a single, more stable one.Chemistry of the Pierce Modified Lowry AssayThe Pierce Modified Lowry Protein Assay is an enhanced biuret assay involving copper-chelation chemistry. Although the mechanism of color formation for the Pierce Modified Lowry Protein Assay is similar to that of the Pierce BCA Protein Assay, there are several significant differences between the two. While the precise mechanism for color formation using the Pierce Modified Lowry Protein Assay is not completely understood, it is known that the reaction occurs as two distinct steps. First, protein reacts with alkaline cupric sulfate in the presence of tartrate during a 10-minute incubation at room temperature. During this incubation, a tetradentate copper complex forms from four peptide bonds and one atom of copper, which is light blue in color (this is the “biuret reaction”). Following the incubation, the Folin phenol reagent is added. It is believed that the color enhancement occurs when the tetradentate copper complex transfers electrons to the phosphomolybdic–phosphotungstic acid complex (the Folin phenol reagent). The reduced phosphomolybdic–phosphotungstic acid complex produced by this reaction is intensely blue in color.Figure 8. Reaction schematic for the Pierce Modified Lowry Protein Assay Kit.Figure 9. Pierce Modified Lowry Protein Assay protocolA55860, A55861, A55862, A55864, A55865,23221,23228,23223,23222,23224,23225,23227,2323023250,2325223235,23231,23232,2323423240A55863, A56979,23209, 23208, 23212, 23213Manuals & protocolsUser Guide: Pierce Dilution-Free Rapid Gold BCA Protein Assay KitUser Guide: Pierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsUser Guide: Pierce BCA Protein Assay Kit − Reducing Agent CompatibleUser Guide: Micro BCA Protein Assay KitUser Guide: Modified Lowry Protein Assay KitApplication & technical guidesTechnical handbook: Protein AssaysTech Tip: Determine acceptable wavelengths for measuring protein assaysTech Tip: Eliminate interfering substances from samples for BCA Protein AssayTech Tip: How to use a protein assay standard curveTech Tip: Protein assay compatibility tableOther literatureLiberate yourself with Pierce Dilution-Free protein assays

BCA assays

  Pierce Dilution-Free Rapid Gold BCA Protein AssayPierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsPierce BCA Protein Assay - Reducing Agent CompatibleMicro BCA Protein AssayAssay range: (sample volume)20–10,000 µg (10 µL)20–2,000 µg/mL (25 µL)125–2,000 µg/mL (9 µL)2–40 µg/mL (150 µL) or 0.5–20 µg/mL (500 µL)Incubation time and temperature5 min at RT30 min at 37°C45 min at 37°C60 min at 60°CTotal assay time10 min45 min115 min130 minAbsorbance480 nm562 nm562 nm562 nmCompatible reagentsDetergentsDetergentsDetergents/reducing agents (e.g. DTT)DetergentsIncompatible reagentsReducing agents; chelatorsReducing agents; chelatorsChelatorsReducing agents; chelatorsUniformityLess protein: protein variation than Bradford assaysLess protein: protein variation than Bradford assaysSignificantly less (14–23%) protein: protein variation than Bradford assaysLess protein: protein variation than Bradford assaysDilution-free protein standardsYesYesNoNoCat. No.A55860 (500 mL)A55861 (250 mL)A55862 (20 mL)A55864 (1000 mL)A55865 (500 mL) Related BCA Kits:23225 (1000 mL)23227 (500 mL)23250 (275 mL/kit)23252 (microplate)23235 (500 mL/kit)Related product: Pierce Dilution Free BSA Protein Standards, Multichannel Pipette Compatible, 0.125–2 mg/mLRelated product: Pierce Dilution-Free BSA Protein Standards, Multichannel Pipette Compatible, 0.125–10 mg/mLBCA kits overviewDilution-Free Rapid Gold BCA Protein Assay – green to yellow (A480 nm), 2-component, precise, detergent compatible assay to measure total protein vs. protein standard in 5 minutes at room temperatureBCA Protein Assay with Dilution-Free BSA Protein Standards – green-to-purple (A562 nm), 2-component, precise, detergent-compatible assay reagent to measure total protein concentration vs. protein standard in 30 minutes at 37°C.BCA Protein Assay - Reducing Agent Compatible – reducing agent–compatible version of our BCA Reagent Kit to measure protein concentration in samples containing DTT or BME thiol-reductants.Micro BCA Protein Assay – special 3-component version of our BCA Reagent Kit to measure total protein concentration of dilute protein solutions (0.5 to 20 μg/mL).Effortless, Fast, AccurateSelect BCA assays now include Dilution-Free BSA Protein Standards which are a set of 7 prediluted BSA standards, uniquely designed for multichannel pipette compatibility.Pierce Dilution-Free standards allow you to eliminate time-consuming and tedious dilutions when generating your standard curve and are calibrated by direct comparison to purified BSA from the National Institute of Standards and Technology (NIST) to help ensure accurate standard curve generation.

BCA assay principles

Chemistry of BCA-based protein assaysThe Pierce BCA Protein Assays combines the well-known reduction of Cu2+ to Cu+ by protein in an alkaline medium (also known as the biuret reaction) with the highly sensitive and selective colorimetric detection of the cuprous cation (Cu+) by bicinchoninic acid (BCA).Figure 1. The first step is the chelation of copper with protein in an alkaline environment to form a blue-colored complex. In this reaction, peptides containing three or more amino acid residues form a colored chelate complex with cupric ions in an alkaline environment containing sodium potassium tartrate.Single amino acids and dipeptides are unaffected in the biuret reaction, but tripeptides and larger polypeptides or proteins will react to produce the light blue-to-violet complex that absorbs light at 540 nm. One cupric ion forms a colored coordination complex with four to six nearby peptides bonds. The intensity of the color produced is proportional to the number of peptide bonds participating in the reaction.Figure 2. In the second step, BCA reagent, a highly sensitive and selective colorimetric detection reagent, reacts with the cuprous cation (Cu+) that was formed in the first step and produces a purple-color.The BCA-copper complex is water-soluble and exhibits a strong linear absorbance at 562 nm with increasing protein concentrations. The purple color may be measured at any wavelength between 550 and 570 nm with minimal (less than 10%) loss of signal. The signal induced by the BCA reagent is approximately 100 times more sensitive (lower limit of detection) than the signal using the biuret reagent.Pierce Dilution-Free Rapid Gold BCA protein assay uses the same copper reduction method as traditional BCA assay with a unique copper chelator. In the second step of the color development reaction, the Pierce Dilution-Free Rapid Gold BCA chelator reacts with the reduced (cuprous) cation (Cu+) that was formed in step one to produce an intensely gold-colored reaction product. The copper complex exhibits a strong linear absorbance at 480 nm with increasing protein concentrations.

Dilution-free BCA protein assays

Dilution-free BSA protein standards are available separately or as part of other BCA protein assays. Compared to the Bradford Assay or Pierce BCA Protein assay kit, the Dilution-Free Rapid Gold BCA Protein Assay reduces assay setup by up to 80% by eliminating the need to dilute samples and standards. Additionally, it only requires a 5-minute, room temperature incubation. The dilution-free BSA protein standards are also available in the BCA Protein Assay Kit with Dilution-Free BSA Protein Standards.Figure 3. The Pierce Dilution-Free Rapid Gold BCA Assay reduces setup time by up to 80% compared to other protein assays. The assays were conducted following the manufacturer’s protocols in a microplate format. Five cell lysates and five pure proteins were prepared to give a total of ten samples. Standard curves for the BCA and Bradford assays were generated through serial dilution of 2 mg/mL bovine serum albumin (BSA) standard. The standard curve for the Pierce Dilution-Free Rapid Gold BCA Assay was generated using Pierce Dilution-Free BSA Protein Standards (included with the kit) packaged in a multichannel pipette-friendly tube strip. Four of the ten samples were expected to have a starting concentration of >2 mg/mL, which necessitated a sample dilution step for the BCA and Bradford assays, whereas samples were not required to be diluted for the Dilution-Free Rapid Gold BCA Assay. Samples were then mixed with working reagent from each assay and incubated according to the manufacturer’s instructions.

Advantages of BCA assays

BCA protein quantificationOne of the major advantages of the BCA assay is that it produces a linear response curve. This response curve allows accurate determination of unknown protein concentrations and provides a higher dynamic range than other standard assays.Figure 4. Pierce Dilution-Free Rapid Gold BCA Protein Assay generates a linear standard curve across a wide dynamic range (0–10 mg/mL). Standard curves were produced for the Pierce Dilution-Free Rapid Gold BCA Protein Assay and the Quick Start Bradford Protein Assay (Bio-Rad) with purified BSA in 0.9% saline (0–10 mg/mL). Both assays were conducted using the manufacturer’s protocols in a microplate format. Absorbance readings were taken using the Thermo Scientific Varioskan LUX Multimode Microplate Reader.

BCA assay accuracy

Another major advantage of BCA protein assays is the accuracy as shown through low protein-to-protein variation. Proteins are diverse in their composition and structure, and with some assays, the proteins’ differences in amino acid sequence, isoelectric point (pI), secondary structure, and side chains or prosthetic groups result in variation in the colorimetric response. Since BCA chemistries develop a color response in proportion to the number of peptide bonds present, they are less affected by these differences when compared to dye-binding assays (e.g. Bradford Assays) and therefore exhibit less protein-to-protein variation.Figure 5. Protein quantification results of the Pierce Dilution-Free Rapid Gold BCA Protein Assay and the Quick Start Bradford Protein Assay compared to samples of known concentration. Both assays were conducted in a microplate format, according to the respective manufacturers’ protocols. For the Bradford assay, 5 μL of sample was added to 250 μL of the Bradford working reagent and incubated at room temperature for 5 minutes. For the Dilution-Free Rapid Gold BCA Protein Assay, 10 μL of sample was added to 200 μL of Dilution-Free Rapid Gold BCA working reagent and incubated at room temperature for 5 minutes. Known concentrations of protein samples were based on manufacturers’ indicated concentrations and were confirmed by absorbance at 280 nm.

BCA protein assay protocols

BCA Protein Assay with Dilution-Free BSA Protein StandardsThe Pierce BCA Protein Assay can be performed using two different formats based upon the dynamic range needed to detect the protein concentration of an unknown sample. This BCA assay detects protein concentrations from 20–2,000 μg/mL using a two-component system: Reagent A, a carbonate buffer containing BCA reagent, and Reagent B, a cupric sulfate solution, which are combined to make an apple green–colored working solution that turns purple after 30 minutes at 37°C in the presence of protein. Since the color reaction is not a true endpoint reaction, considerable protocol flexibility is allowed with the Pierce BCA Protein Assay. By increasing the incubation temperature, the sensitivity of the assay can be increased. When using the enhanced tube protocol (i.e., incubating at 60°C for 30 minutes), the working range for the assay shifts to 5–250 μg/mL, facilitating detection of more dilute samples.Figure 6. BCA Protein Assay Kit with Dilution-Free BSA Protein Standards, multichannel pipe compatible protocol.Dilution-Free Rapid Gold BCA Protein Assay Kit protocolThe Dilution-Free Rapid Gold BCA Protein Assay provides the high sensitivity and linearity associated with the BCA assay but performed within a fraction of the time. Simply mix the BCA working solution, add samples and dilution-free standards to your microplate, incubate for 5 minutes at room temperature, and read the absorbance.Figure 7. Dilution-Free Rapid Gold BCA Protein Assay Kit protocol.

Lowry assays

Modified Lowry Protein Assay KitAssay range: microplate (sample volume)10 to 1,500 µg/mL (40 µL)Assay range: cuvette (sample volume)1–1,500 µg/mL (200 µL)Incubation time and temperature10 and 30 min at RTTotal assay time110 minAbsorbance750 nmCompatible reagentsSDS (up to 1%)Incompatible reagentsReducing reagents, Chelators, detergents, tris, tricine, glycerolUniformityLess protein:protein variation than Coomassie dye methodsProduct size530 mL/kitCat. No.23240Related product: Pierce Dilution Free BSA Protein Standards, Multichannel Pipette Compatible, 2 mg/mLLowry assay principlesThe Pierce Modified Lowry Protein Assay is based on the colorimetric method introduced by Oliver H. Lowry in 1951. The Pierce modified assay replaces two of the assay’s traditional unstable reagents with a single, more stable one.Chemistry of the Pierce Modified Lowry AssayThe Pierce Modified Lowry Protein Assay is an enhanced biuret assay involving copper-chelation chemistry. Although the mechanism of color formation for the Pierce Modified Lowry Protein Assay is similar to that of the Pierce BCA Protein Assay, there are several significant differences between the two. While the precise mechanism for color formation using the Pierce Modified Lowry Protein Assay is not completely understood, it is known that the reaction occurs as two distinct steps. First, protein reacts with alkaline cupric sulfate in the presence of tartrate during a 10-minute incubation at room temperature. During this incubation, a tetradentate copper complex forms from four peptide bonds and one atom of copper, which is light blue in color (this is the “biuret reaction”). Following the incubation, the Folin phenol reagent is added. It is believed that the color enhancement occurs when the tetradentate copper complex transfers electrons to the phosphomolybdic–phosphotungstic acid complex (the Folin phenol reagent). The reduced phosphomolybdic–phosphotungstic acid complex produced by this reaction is intensely blue in color.Figure 8. Reaction schematic for the Pierce Modified Lowry Protein Assay Kit.Figure 9. Pierce Modified Lowry Protein Assay protocol

Ordering

A55860, A55861, A55862, A55864, A55865,23221,23228,23223,23222,23224,23225,23227,2323023250,2325223235,23231,23232,2323423240A55863, A56979,23209, 23208, 23212, 23213

Documents

Manuals & protocolsUser Guide: Pierce Dilution-Free Rapid Gold BCA Protein Assay KitUser Guide: Pierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsUser Guide: Pierce BCA Protein Assay Kit − Reducing Agent CompatibleUser Guide: Micro BCA Protein Assay KitUser Guide: Modified Lowry Protein Assay KitApplication & technical guidesTechnical handbook: Protein AssaysTech Tip: Determine acceptable wavelengths for measuring protein assaysTech Tip: Eliminate interfering substances from samples for BCA Protein AssayTech Tip: How to use a protein assay standard curveTech Tip: Protein assay compatibility tableOther literatureLiberate yourself with Pierce Dilution-Free protein assays

Resources

Pierce Protein methods – an encyclopedia of articles about protein analysisOverview of Protein AssaysChemistry of Protein AssaysProtein Assay Data AnalysisProtein assay technical guide – tools and reagents for improved quantitation of total or specific proteins.Protein assay compatibility table – summarizes compatible substances for several popular protein assays.Protein Analysis Learning Center – resources for different protein analysis techniquesProtein Biology Application Notes – journal-style articles based on research applications and proof-of-concept experimentsLiberate yourself with Pierce Dilution-Free protein assaysFor Research Use Only. Not for use in diagnostic procedures.

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蛋白样品制备

>

裂解及蛋白抽提

蛋白酶抑制剂

磷酸酶抑制剂

蛋白修饰酶抑制剂

蛋白表达与纯化

>

原核蛋白表达

蛋白纯化

蛋白修饰与标记

>

蛋白修饰与去修饰

蛋白标记

蛋白检测

>

蛋白定量

预制胶

蛋白分子量标准

蛋白电泳

Western检测

免疫沉淀

免疫染色

ELISA

新生蛋白质检测

细胞株

>

人细胞株

小鼠细胞株

其它种属细胞株

报告基因细胞株

HEK293T基因敲除细胞(库)

过表达稳转细胞株

细胞组织培养

>

培养液相关

血清

细胞组织消化

原代细胞培养

干细胞培养

内毒素检测与清除

支原体检测与清除

细胞冻存

3D培养

细胞粘附

细胞培养耗材

基因表达调控

>

细胞转染

病毒感染

人基因编辑慢病毒(库)

细胞样品制备

>

细胞组分分离

蛋白样品制备

RNA样品制备

DNA样品制备

细胞裂解样品

>

HEK293T基因敲除细胞RIPA裂解液

HEK293T基因敲除细胞Trizol裂解液

细胞增殖与分化

>

干细胞检测

细胞增殖

细胞分化

细胞衰老

细胞死亡与自噬

>

细胞凋亡

细胞坏死

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自噬

细胞组织染色

>

普通染色

荧光染色

免疫染色

亚细胞研究

>

细胞膜

细胞核

线粒体

内质网

高尔基体

溶酶体

外泌体

植物原生质体

信号小分子检测

>

活性氧相关

一氧化氮相关

代谢小分子相关

钙离子等检测

转录调控

>

报告基因相关

EMSA相关

核转运

荧光探针

>

小分子荧光探针

细胞凋亡荧光探针

细胞器荧光探针

其它荧光探针

抗体制备

>

免疫佐剂

抗体纯化

抗体分析

二抗

>

HRP标记二抗

Biotin标记二抗

ALP标记二抗

荧光标记二抗

常用一抗

>

内参抗体

标签抗体

细胞器标志抗体

细胞标志抗体

对照IgG

敲除验证抗体

修饰抗体

荧光标记一抗

HRP标记一抗

IHC抗体

凋亡与自噬

>

Regulation of Apoptosis

Inhibition of Apoptosis

Death Receptor Signaling

Mitochondrial Control of Apoptosis

Autophagy Signaling

p53 Signaling

细胞代谢

>

Insulin Signaling

AMPK Signaling

Warburg Effect

Hypoxia Signaling

Glucose metabolism

Fatty Acid Metabolism

Endocrinology & Hormones

Transmembrane Transporters

Glutamine Metabolism

Other Metabolism

染色质/表观遗传/细胞周期

>

Protein Acetylation

Histone Methylation

DNA Methylation

Crosstalk Between Protein Modifications

G1/S Checkpoint

G2M/DNA Damage Checkpoint

RNA Editing/Splicing

Epigenetics

DNA Damage and Repair

Nuclear Receptor Signaling

Chromatin Regulation

Cell Cycle Related

细胞骨架/细胞外基质

>

Microtubule Dynamics

Actin Dynamics

Adherens Junction Dynamics

Cytoskeletal Signaling

免疫与炎症

>

Jak/Stat:IL-6 Signaling

NF-κB Signaling

Toll-Like Receptor Signaling

B Cell Receptor Signaling

T Cell Receptor Signaling

Cytokines

Chemokines

Tumor Necrosis Factors

Anti-infection

Interferons

T-Cell/B-Cell Activation

Macrophages

Complement Activation

Other Immune Pathways

MAPK与PI3K/Akt通路

>

MAPK/Erk in Growth & Differentiation

MAPK/Erk in GPCR Signaling

SAPK/JNK Signaling

p38 MAPK Signaling

PI3K/Akt Signaling

mTOR Signaling

MAP Kinase Signaling

Protein Tyrosine Kinase Signaling

神经科学

>

Amyloid & Neurofibrillary Tangles

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Presynaptic Vesicle Transport

Neuronal Signaling

PKC、钙离子及脂信号通路

>

PKC Signaling

Phospholipid Signaling

Protein Posttranslational Modification

干细胞、发育与分化

>

Hippo Signaling

ESC Pluripotency and Differentiation

Stem Cell & Lineage Markers

Wnt/β-Catenin Signaling

Notch Signaling

Hedgehog Signaling

TGF-β Signaling

Angiogenesis

蛋白翻译、折叠和降解

>

Translational Regulation

eIF4E & p70 S6K Pathway

eIF2 Pathway

Ubiquitin/Proteasome

Protein Folding

肿瘤研究

>

Breast Cancer

Tumor Immunology

其它类别一抗

>

ErbB/HER Signaling

Organelle Markers

Coagulation

Microbiology

Growth Factors

Transcription Factors

Signal Transduction

Others

化合物库

>

药物库

天然化合物

凋亡与自噬

>

Regulation of Apoptosis

Inhibition of Apoptosis

Death Receptor Signaling

Mitochondrial Control of Apoptosis

Autophagy Signaling

细胞代谢

>

Insulin Signaling

AMPK Signaling

Warburg Effect

Hypoxia Signaling

Glucose Metabolism

Fatty Acid Metabolism

Transmembrane Transporters

染色质/表观遗传/细胞周期

>

Protein Acetylation

Histone Methylation

Crosstalk Between Protein Modifications

G1/S Checkpoint

G2M/DNA Damage Checkpoint

细胞骨架/细胞外基质

>

Microtubule Dynamics

Actin Dynamics

Adherens Junction Dynamics

免疫与炎症

>

Jak/Stat:IL-6 Signaling

NF-κB Signaling

Toll-Like Receptor Signaling

B Cell Receptor Signaling

T Cell Receptor Signaling

Antimicrobial Signaling

MAPK与PI3K/Akt通路

>

MAPK/Erk in Growth & Differentiation

MAPK/Erk in GPCR Signaling

SAPK/JNK Signaling

p38 MAPK Signaling

PI3K/Akt Signaling

mTOR Signaling

Protein Tyrosine Kinase Signaling

神经科学

>

Dopamine Signaling

Presynaptic Vesicle Trafficking

Neurotransmission

PKC、钙离子及脂信号通路

>

PKC Signaling

Phospholipid Signaling

干细胞、发育与分化

>

Wnt/β-Catenin Signaling

Notch Signaling

Hedgehog Signaling

TGF-β Signaling

蛋白翻译、折叠和降解

>

Translational Regulation

Ubiquitin/Proteasome

其它类别抑制剂激活剂

>

Nuclear Receptor Signaling

ErbB/HER Signaling

Angiogenesis

Coagulation

Anti COVID-19

生化试剂

>

糖类

氨基酸

多肽与蛋白

脂类

核酸相关

辅酶

代谢物

激素

维生素

微生物培养

显色剂

去垢剂

螯合剂

溶剂

氧化还原试剂

其它生化试剂

分离纯化试剂

造模试剂

染色剂

校正溶液

点击化学

常用酶

>

核酸酶

蛋白酶

其它常用酶

抗生素与防腐剂

>

哺乳动物细胞培养

细菌培养

真菌培养

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消毒剂

缓冲试剂/缓冲液

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缓冲试剂

pH缓冲液

电泳/转膜缓冲液

其它缓冲液

储存液

>

钠盐溶液

其它储存液

植物相关

>

植物培养

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微生物检测

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微生物活性检测

试剂存放

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离心管

离心管架

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冰盒

蓝盖瓶

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细胞培养

>

培养皿

培养瓶

培养板

冻存管

移液管

离心管

细胞刮铲

细胞过滤

血清瓶

三角摇瓶

PCR耗材

>

PCR管

PCR排管和盖

PCR板

PCR板封板膜

PCR管盒

印迹与检测

>

PVDF膜

硝酸纤维素膜

尼龙膜

电泳及转印

洗膜盒

胶片

暗盒与增感屏

染色与检测

>

载玻片

盖玻片

存储盒

染色缸染色架

其它染色耗材

防护用品

>

手套

工作服

一次性帽子

一次性口罩

一次性鞋套

分离纯化

>

空柱管

超滤管

透析袋/透析袋夹

配件

切胶器

金属器械

>

剪刀

镊子

刀柄刀片

钳子

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小动物手术器械

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>

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记号笔

其它

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>

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金属浴

脱色摇床

混匀仪

离心机

搅拌器

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混合与破碎

>

脱色摇床

细菌培养摇床

漩涡振荡器

混匀仪

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分离与浓缩

>

离心机

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氮吹仪

旋转蒸发仪

泵与真空设备

>

真空泵及其它泵

蠕动泵

安全与防护

>

生物安全柜

超净工作台

危化品安全柜

通风橱

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清洗净化消毒

>

洗瓶机

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纯水仪

灭菌设备

冷冻冷藏

>

制冰机

低温冰箱

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液氮罐

超低温冰箱、液氮罐分隔架

层析柜

核酸蛋白分析

>

PCR仪

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蛋白转印设备

核酸提取设备

观察与成像

>

紫外分析仪

凝胶成像分析系统

光学检测

>

分光光度计

化学发光分析仪

酶标仪

其它光学检测仪器

组织与动物

>

切片机

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组织脱水机

染色机

其它动物实验仪器

理化分析

>

移液器类

天平

pH计

电导仪

氧化还原电位仪

溶氧仪

食品安全检测仪

小型计量仪表

>

定时器

核酸相关

>

引物合成

0.5元/nt起

RNA合成

520元/条起

基因合成

450元/条起

质粒构建

点突变423元起

定量PCR

50元/3复孔起

高通量测序

RNA-seq 998元起

SNP基因分型

4.5元/位点/样本起

质粒DNA制备

1mg 1430元起

DNA测序

15元/反应起

植物基因

PCR60元/3复孔起

环形RNA合成

RNA环化1288元/起

代为检测服务

10元/样起

蛋白相关

>

多肽合成

21元/氨基起

蛋白表达纯化

5000元/样起

抗体定制

兔多抗2800元/样起

Western Blot

500元/膜起

ELISA

代测300元/板起

免疫荧光

拍照30元/片起

免疫组化

60元/片起

免疫共沉淀

1800/样品起

蛋白质组学

1800元/样起

生化检测

代测10元/样起

代为检测服务

10元/样起

细胞相关

>

细胞增殖检测

600元/板起

细胞凋亡检测

100元/样起

CRISPR/Cas9

9999元/株起

病毒包装

腺病毒5590元起

细胞系STR鉴定

600元/样起

细胞株

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石蜡切片

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支原体检测

280元/样起

代为检测服务

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信号转导相关

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代谢组学

900元/样起

外泌体检测

298元/样起

EMSA探针合成

638元/管起

代为检测服务

10元/样起

药物与疾病

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化合物定制合成

1800元/样起

类器官

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动物药效学实验

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代为检测服务

10元/样起

其它

>

SCI论文服务

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询价

COVID-19核酸检测

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qPCR

等温扩增

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清除环境污染

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病毒保存

COVID-19机理研究

>

新冠病毒结构蛋白表达质粒

新冠病毒重组蛋白

新冠病毒结构蛋白抗体

主蛋白酶相关

ACE2相关

炎症和免疫反应监测

COVID-19药物研发

>

蛋白酶

蛋白酶荧光底物

抑制剂筛选试剂盒

FDA批准药物库化合物

COVID-19相关仪器

>

仪器

COVID-19技术服务

>

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试剂>

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P0011

Y

BCA蛋白浓度测定试剂盒

一键复制产品信息

产品编号:

P0012

产品包装:500次

选择包装

200次

500次

5000次

说明书下载

329.00

318.00

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产品简介

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P0012S

BCA蛋白浓度测定试剂盒

200次

172.00元

P0012

BCA蛋白浓度测定试剂盒

500次

329.00元

P0011

BCA蛋白浓度测定试剂盒

5000次

1592.00元

      BCA蛋白浓度测定试剂盒(BCA Protein Assay Kit)是根据目前世界上最常用的两种蛋白浓度检测方法之一BCA法研制而成,实现了蛋白浓度测定的简单、高稳定性、高灵敏度和高兼容性。

      灵敏度高,检测浓度下限达到25μg/ml,最小检测蛋白量达到0.5μg,待测样品体积为1-20μl。

      在50-2000μg/ml浓度范围内有较好的线性关系。

      BCA法测定蛋白浓度不受绝大部分样品中的化学物质的影响,可以兼容样品中高达5%的SDS,5%的Triton X-100,5%

的Tween 20、60、80。但本试剂盒受螯合剂和略高浓度的还原剂的影响,需确保EDTA低于10mM,无EGTA,二硫苏糖醇

(DTT)低于1mM,β-巯基乙醇(β-Mercaptoethanol)低于0.01%。不适用BCA法时建议试用碧云天生产的Bradford蛋白浓度测定试剂盒(P0006)。

      BCA蛋白浓度测定试剂盒对样品中各种物质的详细的兼容性,请参见碧云天如下网页:

      http://www.beyotime.com/Compatibility Chart For BCA Kit.pdf

      每个试剂盒可以检测5000个样品。

包装清单:

产品编号

产品名称

包装

P0012-1

BCA试剂 A

100ml

P0012-2

BCA试剂 B

3ml

P0012-3

蛋白标准(BSA)

30mg

P0012-4

蛋白标准配制液

1.5ml

说明书

1份

保存条件:

室温保存。蛋白标准配制成溶液后-20℃冻存。

注意事项:

需酶标仪一台,测定波长为540-595nm之间,562nm最佳。需96孔板。如果没有酶标仪,也可以使用普通的分光光度计测定,但测定时,需根据比色皿的最小检测体积,适当加大BCA工作液的用量使不小于最小检测体积,样品和标准品的用量可相应按比例放大也可不变。使用分光光度计测定蛋白浓度时,每个试剂盒可以测定的样品数量可能会显著减少。

如发现样品稀释液或裂解液本身就有较高背景,请试用碧云天生产的Bradford蛋白浓度测定试剂盒(P0006)。

为了加快BCA法测定蛋白浓度的速度可以适当用微波炉加热,但是切勿过热。

EDTA浓度必须小于10mM,不兼容EGTA。不适用BCA法时,请试用碧云天生产的Bradford蛋白浓度测定试剂盒(P0006)。

本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。

为了您的安全和健康,请穿实验服并戴一次性手套操作。 

使用说明:

1.蛋白标准品的准备

a.取1.2ml蛋白标准配制液加入到一管蛋白标准(30mg BSA)中,充分溶解后配制成25mg/ml的蛋白标准溶液。配制后可立即使用,也可以-20℃长期保存。

b.取适量25mg/ml蛋白标准,稀释至终浓度为0.5mg/ml。例如取20µl 25mg/ml蛋白标准,加入980µl稀释液即可配制成0.5mg/ml蛋白标准。蛋白样品在什么溶液中,标准品也宜用什么溶液稀释。但是为了简便起见,也可以用0.9% NaCl或PBS稀释标准品。稀释后的0.5mg/ml蛋白标准可以-20℃长期保存。

2.BCA工作液配制

根据样品数量,按50体积BCA试剂A加1体积BCA试剂B(50:1)配制适量BCA工作液,充分混匀。例如5mlBCA试剂A加100μl BCA试剂B,混匀,配制成5.1ml BCA工作液。BCA工作液室温24小时内稳定。

3.蛋白浓度测定

a.将标准品按0、1、2、4、8、12、16、20μl加到96孔板的标准品孔中,加标准品稀释液补足到20μl,相当于标准品浓度分别为0、0.025、0.05、0.1、0.2、0.3、0.4、0.5mg/ml。

b.加适当体积样品到96孔板的样品孔中。如果样品不足20μl,需加标准品稀释液补足到20μl。请注意记录样品体积。

c.各孔加入200μl BCA工作液,37℃放置20-30分钟。

注: 也可以室温放置2小时,或60℃放置30分钟。BCA法测定蛋白浓度时,颜色会随着时间的延长不断加深。并且显色反应会因温度升高而加快。如果浓度较低,适合在较高温度孵育,或适当延长孵育时间。

d.用酶标仪测定A562,或540-595nm之间的其他波长的吸光度。

e.根据标准曲线和使用的样品体积计算出样品的蛋白浓度。

常见问题:

1. 测定标准曲线时发现随着标准品浓度的增加吸光度或颜色没有明显变化。

可能的原因是样品中含有严重干扰BCA法测定蛋白浓度的物质,详细的BCA法的兼容性列表请参考碧云天如下网页:http://www.beyotime.com/Compatibility Chart For BCA Kit.pdf

2.是否每次测定时都需要做标准曲线?

建议每次测定时都做标准曲线。因为BCA法测定时颜色会随着时间的延长不断加深,并且显色反应的速度和温度有关,所以除非精确控制显色反应的时间和温度,否则如需精确测定宜每次都做标准曲线。

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.

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2004年第6期第377页。

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.

Cholesterol in U937 foam cells assayed in liquid chromatographic-mass spectrometry.

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2004;14(20): 51-56.

(IF 2.014)

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.

Mitochondrial dysfunction as an early event in the process of apoptosis induced by woodfordin I in human leukemia K562 cells.

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2004 Jan 15;194(2):141-55.

(IF 3.616)

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.

Dual effects of cycloheximide on U937 apoptosis induced by its combination with VP-16.

Biol Pharm Bull.

2004 Jul;27(7):1075-80.

(IF 1.863)

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.

A protein delivery system: biodegradable alginate-chitosan-poly(lactic-co-glycolic acid) composite microspheres.

BIOCHEM BIOPH RES CO.

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(IF 2.985)

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.

Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria.

Cancer Lett.

2005;224:229–241.

(IF 7.36)

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.

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J VIROL.

2005 sep;21(5):376-83.

(IF 4.501)

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.

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2005;20(5):375-7.

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.

Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis.

CANCER CHEMOTH PHARM.

2005 Jan;55(1):79-90.

(IF 2.967)

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.

TatPTD can introduce HBV targeted ribonuclease into hepatocytes.

世界华人消化杂志.

2005 Apr 15;13(8):958-962.

33. Zhao Y, Guan H, Liu SF, Wu RC, Wang Z.

.

Overexpression of QM induces cell differentiation and mineralization in MC3T3-E1.

Biol Pharm Bull.

2005 Aug;28(8):1371-6.

(IF 1.863)

34. Zhang LF, Peng SQ, Wang S.

.

Influence of lead (Pb2+) on the reactions of in vitro cultured rat aorta to 5-hydroxytryptamine.

Toxicol Lett.

2005 Oct 15;159(1):71-82.

(IF 3.569)

35. Ma JF, Guo JK, Peng LW, Chen CY, Zhang LX.

.

Decrease of photosystem II photochemistry in Arabidopsis ppt1 mutant is dependent on leaf age.

J Integr Plant Biol.

2006;48(12):1409-1414.

(IF 4.885)

36. Huang YY, Deng JY, Gu J, Zhang ZP, Maxwell A, Bi LJ, Chen YY, Zhou YF, Yu ZN, Zhang XE.

.

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Nucleic Acids Res.

2006;34(19):5650-9.

(IF 11.501)

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.

Involvement of cAMP/cAMP-dependent protein kinase signaling pathway in regulation of Na+,K+-ATPase upon activation of opioid receptors by morphine.

Mol Pharmacol.

2006 Mar;69(3):866-76.

(IF 3.664)

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.

Tellimagrandin I enhances gap junctional communication and attenuates the tumor phenotype of human cervical carcinoma HeLa cells in vitro.

Cancer Lett.

2006 Oct 8;242(1):77-87.

(IF 7.36)

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.

Covalent binding of -chymotrypsin on the magnetic nanogels covered by amino groups.

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2007;45:84–90.

(IF 2.269)

40. Wang M, Long AH, Liu CH, Ji G.

.

Effect of Qinggan Huoxue recipe and its separated recipe on ERK signal ing pathway in Kupffer cell mediated by LPS.

HIN J INTEGR MED.

2007;17(5):277-280.

(IF 1.346)

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.

Effects of dietary thiamin on the physiological status of the grouper Epinephelus coioides.

Fish Physiol Biochem.

2007;33:167–172.

(IF 2.242)

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.

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2007;28(11):1014-1017.

43. Wang YC, Zou QM, Mao XH, Guo G, Xie QH.

.

A prelim inary non2clin ica l study of Helicobacter pylori m icrospheres vacc ine.

《中国新药杂志》.

2007;16(7):539-543.

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.

Regulative Effects of"Qinggan Huoxue Recipe" and Its Separated Recipes on Kupffer Cells Mediated by LPS.

shanghai journal of traditional chinese medicine.

2007 Jan;41(1):18-21.

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.

Inh ib ition of Polypeptide from Chlamys fa rreri on UVA2Induced Apoptosis of HaCaT Cells Depending on p38MAPK Pa thway and Ca spase23.

中国药科大学学报.

2007 Jan;42(2):116-120.

46. Wu ZQ, Chen J, Chi ZQ, Liu JG.

.

Involvement of dopamine system in regulation of Na+,K+-ATPase in the striatum upon activation of opioid receptors by morphine.

Mol Pharmacol.

2007 Feb;71(2):519-30.

(IF 3.664)

47. Gao J, Zhao YN, Jiang QW.

.

Investigation of Asymptomatic Infection of Echovirus 30 in Population of Shanghai.

Journal of the virus.

2007 Mar;23(2):121-124.

48. Zhang LF, Peng SQ, Wang S, Li BL, Han G, Dong YS.

.

Direct effects of lead (Pb2+) on the relaxation of in vitro cultured rat aorta to acetylcholine.

Toxicol Lett.

2007 Apr 25;170(2):104-10.

(IF 3.569)

49. Deng XQ, Chen LL, Li NX.

.

The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats.

Liver Int.

2007 Jun;27(5):708-15.

(IF 5.175)

50. Gao MQ, Guo SB, Chen XH, Du W, Wang CB.

.

Molecular mechanisms of polypeptide from Chlamys farreri protecting HaCaT cells from apoptosis induced by UVA plus UVB.

Acta Pharmacol Sin.

2007 Jul;28(7):1007-14.

(IF 5.064)

51. Dong S, Li C, Wu P, Tsien JZ, Hu Y.

.

Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice.

Eur J Neurosci.

2007 Jul;26(1):101-12.

(IF 3.115)

52. Wang Q, Liang C, Song J, Chen X.

.

HA2 from the Helicoverpa armigera nucleopolyhedrovirus: a WASP-related protein that activates Arp2/3-induced actin filament formation.

Virus Res.

2007 Jul;127(1):81-7.

(IF 2.934)

53. Wang YC, Zou QM, Ren JM, Guo G, Xie QH, Liu j.

.

Study of the microspheres technology of Helicobacter pylori whole cell protein encapsulated by chitosan2alginate.

Journal of Chongqing Medical University 重庆医科大学学报.

2007 July;36(13):121-124.

54. Li JL, Liu N, Chen XH, Sun M, Wang CB.

.

Inhibition of UVA-induced apoptotic signaling pathway by polypeptide from Chlamys farreri in human HaCaT keratinocytes.

RADIAT ENVIRON BIOPH.

2007 Aug;46(3):263-8.

(IF 1.321)

55. Yuan QL, Yang CX, Xu P, Gao XQ, Deng L, Chen P, Sun ZL, Chen QY.

.

Neuroprotective effects of ginsenoside Rb1 on transient cerebral ischemia in rats.

Brain Res.

2007 Sep 5;1167:1-12.

(IF 2.733)

56. Chen YR, Nie SD, Shan W, Jiang DJ, Shi RZ, Zhou Z, Guo R, Zhang Z, Li YJ.

.

Decrease in endogenous CGRP release in nitroglycerin tolerance: role of ALDH-2.

Eur J Pharmacol.

2007 Sep 24;571(1):44-50.

(IF 3.263)

57. Yi ZC, Wang H, Zhang GY, Xia B.

.

Downregulation of connexin 43 in nasopharyngeal carcinoma cells is related to promoter methylation.

Oral Oncol.

2007 Oct;43(9):898-904.

(IF 3.979)

58. Wang ZL, Li JL, Wang CB.

.

The role of tumor necrosis factor rela ted apoptosis induc ing ligand and Polypeptide from Chlam ys fa rreri in UVA2induced apoptosis in HaCaT cells.

《中国药理学通报》.

2007 Oct;23(10):1375-9.

59. Zhang Y, Zhen DX, Ren TL, Wang DP.

.

The Character istics Effects of Ga tifloxac in on L iverM icrosome Cytochrome P450 in Rats.

pharm j chin pla.

2007 Dec;23(6):404-407.

60. Pan YQ, Ding D, Li DX, Chen SQ.

.

Expression and bioactivity analysis of Staphylococcal enterotoxin M and N.

PROTEIN EXPRES PURIF.

2007 Dec;56(2):286-92.

(IF 1.513)

61. Nie H, Li Z, Lukas RJ, Shen Y, Song L, Wang X, Yin M.

.

Construction of SH-EP1-alpha4beta2-hAPP695 Cell Line and Effects of Nicotinic Agonists on beta-amyloid in the Cells.

Cell Mol Neurobiol.

2008 Jan;28(1):103-12.

(IF 3.606)

62. Zhang DW, Cheng Y, Wang NL, Zhang JC, Yang MS, Yao XS.

.

Effects of total flavonoids and flavonol glycosides from Epimedium koreanum Nakai on the proliferation and differentiation of primary osteoblasts.

Phytomedicine.

2008 Jan;15(1-2):55-61.

(IF 4.268)

63. Zhang H, Deng JY, Bi LJ, Zhou YF, Zhang ZP, Zhang CG, Zhang Y, Zhang XE.

.

Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase.

FEBS J.

2008 Feb;275(4):753-62.

(IF 4.392)

64. Liu C, Wang Q, Guo H, Xia M, Yuan Q, Hu Y, Zhu H, Hou M, Ma J, Tang Z, Ling W.

.

Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine.

J Nutr.

2008 Feb;138(2):311-5.

(IF 4.281)

65. Zhang GG, Bai YP, Chen MF, Shi RZ, Jiang DJ, Fu QM, Tan GS, Li YJ.

.

Asymmetric dimethylarginine induces TNF-alpha production via ROS/NF-kappaB dependent pathway in human monocytic cells and the inhibitory effect of reinioside C.

VASC PHARMACOL.

2008 Feb-Mar;48(2-3):115-21.

(IF 4.152)

66. Yu S, Geng J, Zhou P, Wang J, Feng A, Chen X, Tong H, Hu J.

.

Application of a new hybrid organic-inorganic monolithic column for efficient deoxyribonucleic acid purification.

Anal Chim Acta.

2008 Mar 24;611(2):173-81.

(IF 5.977)

67. Yu S, Geng J, Zhou P, Wang J, Chen X, Hu J.

.

New hydroxyapatite monolithic column for DNA extraction and its application in the purification of Bacillus subtilis crude lysate.

J Chromatogr A.

2008 Mar 7;1183(1-2):29-37.

(IF 4.049)

68. Wang Y, Peng KM, Li JL, Song H, Li SH, Wei L, Wang JX.

.

Ultrastructure and melatonin 1a receptor distribution in the ovaries of African ostrich chicks.

Cytotechnology.

2008 Mar;56(3):187-95.

(IF 1.777)

69. Zhang GG, Shi RZ, Jiang DJ, Chen YR, Jia-Chen, Tang ZY, Bai YP, Xiao HB, Li YJ.

.

Involvement of the endothelial DDAH/ADMA pathway in nitroglycerin tolerance: the role of ALDH-2.

Life Sci.

2008 Mar 26;82(13-14):699-707.

(IF 3.647)

70. Li J, Liu W, Ding S, Xu W, Guan Y, Zhang JH, Sun X.

.

Hyperbaric oxygen preconditioning induces tolerance against brain ischemia-reperfusion injury by upregulation of antioxidant enzymes in rats.

Brain Res.

2008 May 19;1210:223-9.

(IF 2.733)

71. Fu Y, Zhang Z, Zhang G, Liu Y, Cao Y, Yu J, Hu J, Yin X.

.

Adenovirus-mediated gene transfer of tissue factor pathway inhibitor induces apoptosis in vascular smooth muscle cells.

Apoptosis.

2008 May;13(5):634-40.

(IF 4.543)

72. Tian B, Wang Z, Zhao Y, Wang D, Li Y, Ma L, Li X, Li J, Xiao N, Tian J, Rodriguez R.

.

Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model.

Cancer Lett.

2008 Jun 18;264(2):299-308.

(IF 7.36)

73. Gao F, Wu DQ, Hu YH, Jin GX, Li GD, Sun TW, Li FJ.

.

In vitro cultivation of islet-like cell clusters from human umbilical cord blood-derived mesenchymal stem cells.

Transl Res.

2008 Jun;151(6):293-302.

(IF 5.411)

74. He X, Zhang Z, Zhang H, Zhao Y, Chai Z.

.

Neurotoxicological evaluation of long-term lanthanum chloride exposure in rats.

Toxicol Sci.

2008 Jun;103(2):354-61.

(IF 3.703)

75. Wan F, You J, Sun Y, Zhang XG, Cui FD, Du YZ, Yuan H, Hu FQ.

.

Studies on PEG-modified SLNs loading vinorelbine bitartrate (I): preparation and evaluation in vitro.

INT J PHARMACOL.

2008 Jul 9;359(1-2):104-10.

(IF 0.692)

76. An R, Dong C, Lei Y, Han L, Li P, Chen J, Wang G, Shi Q, Gao C, Jiang H, Zhou W, Han J, Chu Y, Dong X.

.

PrP mutants with different numbers of octarepeat sequences are more susceptible to the oxidative stress.

SCI CHINA LIFE SCI.

2008 Jul;51(7):630-9.

(IF 4.611)

77. Wei Y, Weng D, Li F, Zou X, Young DO, Ji J, Shen P.

.

Involvement of JNK regulation in oxidative stress-mediated murine liver injury by microcystin-LR.

Apoptosis.

2008 Aug;13(8):1031-42.

(IF 4.543)

78. Tian SL, Wang XY, Ding GH.

.

Repeated electro-acupuncture attenuates chronic visceral hypersensitivity and spinal cord NMDA receptor phosphorylation in a rat irritable bowel syndrome model.

Life Sci.

2008 Aug 29;83(9-10):356-63.

(IF 3.647)

79. Chen M, Li Y, Yang T, Wang Y, Bai Y, Xie X.

.

ADMA induces monocyte adhesion via activation of chemokine receptors in cultured THP-1 cells.

Cytokine.

2008 Aug;43(2):149-59.

(IF 2.952)

80. Hu X, Zhou J, Zhang N, Tan H, Gao C.

.

Preparation and properties of an injectable scaffold of poly(lactic-co-glycolic acid) microparticles/chitosan hydrogel.

J MECH BEHAV BIOMED.

2008 Oct;1(4):352-9.

(IF 3.372)

81. Sun J, Wu Y, Wang J, Ma F, Liu X, Li Q.

.

Novel translationally controlled tumor protein homologue in the buccal gland secretion of Lampetra japonica.

Biochimie.

2008 Nov-Dec;90(11-12):1760-8.

(IF 3.413)

82. Zhu M, Gu F, Shi J, Hu J, Hu Y, Zhao Z.

.

Increased oxidative stress and astrogliosis responses in conditional double-knockout mice of Alzheimer-like presenilin-1 and presenilin-2.

FREE RADICAL BIO MED.

2008 Nov 15;45(10):1493-9.

(IF 6.17)

83. Liu XJ, Wang WC, Wang HJ, Zhang LL, Liu LQ, Wang YJ, Wang CB.

.

A polypeptide from Chlamys farreri inhibits UVB-induced HaCaT cells apoptosis via the Apaf-1/caspase-9 and Smac/XIAP signaling pathway.

Chinese Journal of Oceanology and Limnology.

2009;27(3):587-593.

(IF 0.741)

84. Fan L, Lin C, Zhuo S, Chen L, Liu N, Luo Y, Fang J, Huang Z, Lin Y, Chen J.

.

Transplantation with survivin-engineered mesenchymal stem cells results in better prognosis in a rat model of myocardial infarction.

Eur J Heart Fail.

2009;11(11):1023-30.

(IF 11.627)

85. Yi Q, Wen X, Li L, He B, Nie Y, Yao Wu Y, Zhang Z, Gu Z.

.

The chiral effects on the responses of osteoblastic cells to the polymeric substrates.

European Polymer Journal.

2009;45:1970–8.

(IF 3.621)

86. ZHANG ZY, LIU XJ, LIU T, YAN L, WANG YJ, WANG CB.

.

Polypeptide from Chlamys farreri inhibits UVB-induced apoptosis of HaCaT cells via iNOS/NO and HSP90.

Chinese Journal of Oceanology and Limnology.

2009;27(3):594-599.

(IF 0.741)

87. WU T, NAN KH, CHEN JD, JIN D, JIANG S, ZHAO PR, XU JC, DU H, ZHANG XQ, LI JW, PEI GX.

.

A new bone repair scaffold combined with chitosan/hydroxyapatite and sustained releasing icariin.

CHINESE SCI BULL.

2009;54(17):2953-2961.

(IF 1.649)

88. Li W, Liu Y, Zhang JW, Ai CZ, Xiang N, Liu HX, Yang L.

.

Anti-androgen-independent prostate cancer effects of ginsenoside metabolites in vitro: mechanism and possible structure-activity relationship investigation.

Arch Pharm Res.

2009 Jan;32(1):49-57.

(IF 2.934)

89. Yuan Q, Li PD, Li BH, Yang XZ, Xu SB, Liu XH, Zhou FX, Zhang WJ.

.

Differential IL-4/Stat6 activities correlate with differential expression of regulatory genes SOCS-1, SHP-1, and PP2A in colon cancer cells.

J CANCER RES CLIN.

2009 Jan;135(1):131-140.

(IF 3.656)

90. Wang YL, Wang CY, Zhang BJ, Zhang ZZ.

.

Shenfu injection suppresses apoptosis by regulation of Bcl-2 and caspase-3 during hypoxia/reoxygenation in neonatal rat cardiomyocytes in vitro.

Mol Biol Rep.

2009 Feb;36(2):365-70.

(IF 1.402)

91. Liu XS, Jiang J, Jiao XY, Wu YE, Lin JH, Cai YM.

.

Lycorine induces apoptosis and down-regulation of Mcl-1 in human leukemia cells.

Cancer Lett.

2009 Feb 8;274(1):16-24.

(IF 7.36)

92. Gao R, Wang J, Shen Y, Lei M, Wang Z.

.

Functional expression of voltage-gated sodium channels Nav1.5 in human breast caner cell line MDA-MB-231.

J HUAZHONG U SCI-MED.

2009 Feb;29(1):64-7.

(IF 1.151)

93. Liu X, Zhang Z, Li P, Zhu L, Wang Y, Wang C.

.

Polypeptide from Chlamys farreri modulates UVB-induced activation of NF-kappaB signaling pathway and protection HaCaT cells from apoptosis.

REGUL PEPTIDES.

2009 Feb 25;153(1-3):49-55.

(IF 1.813)

94. Jin D, Ojcius DM, Sun D, Dong H, Luo Y, Mao Y, Yan J.

.

Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways.

Infect Immun.

2009 Feb;77(2):799-809.

(IF 3.201)

95. Kang Y, Hu M, Zhu Y, Gao X, Wang MW.

.

Antioxidative effect of the herbal remedy Qin Huo Yi Hao and its active component tetramethylpyrazine on high glucose-treated endothelial cells.

Life Sci.

2009 Mar 27;84(13-14):428-36.

(IF 3.647)

96. Xu J, Wang S, Lin Y, Cao L, Wang R, Chi Z.

.

Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats.

Neurosci Lett.

2009 Mar 27;453(1):58-61.

(IF 2.274)

97. Jia H, Qi X, Fang S, Jin Y, Han X, Wang Y, Wang A, Zhou H.

.

Carnosine inhibits high glucose-induced mesangial cell proliferation through mediating cell cycle progression.

REGUL PEPTIDES.

2009 Apr 10;154(1-3):69-76.

(IF 1.813)

98. Zhang LF, Peng SQ, Wang S.

.

Decreased aortic contractile reaction to 5-hydroxytryptamine in rats with long-term hypertension induced by lead (Pb(2+)) exposure.

Toxicol Lett.

2009 Apr 25;186(2):78-83.

(IF 3.569)

99. Dong C, Wang Y, Zhu YZ.

.

Asymmetric synthesis and biological evaluation of Danshensu derivatives as anti-myocardial ischemia drug candidates.

BIOORG MED CHEM LETT.

2009 May 1;17(9):3499-507.

(IF 2.572)

100. Xiao X, Liu A, Wen H, Tian Y, Ni J, Liu G.

.

Expression and localization of transcription factor Ets-1 in the rat ovary during the estrous cycle and pregnancy.

Fertil Steril.

2009 May;91(5):1998-2005.

(IF 6.312)

101. Cheng B, Song J, Zou Y, Wang Q, Lei Y, Zhu C, Hu C.

.

Responses of vascular smooth muscle cells to estrogen are dependent on balance between ERK and p38 MAPK pathway activities.

Int J Cardiol.

2009 May 29;134(3):356-65.

(IF 3.229)

102. Chen MF, Li YJ, Yang TL, Lou B, Xie XM.

.

Losartan inhibits monocytic adhesion induced by ADMA via downregulation of chemokine receptors in monocytes.

Eur J Clin Pharmacol.

2009 May;65(5):457-64.

(IF 2.641)

103. Zhang DL, Chen YQ, Jiang X, Ji TT, Mei B.

.

Oxidative damage increased in presenilin1/presenilin2 conditional double knockout mice.

Neurosci Bull.

2009 Jun;25(3):131-7.

(IF 4.326)

104. Wang XD, Meng MX, Gao LB, Liu T, Xu Q, Zeng S.

.

Permeation of astilbin and taxifolin in Caco-2 cell and their effects on the P-gp.

INT J PHARMACOL.

2009 Aug 13;378(1-2):1-8.

(IF 0.692)

105. Chen B, Gao XQ, Yang CX, Tan SK, Sun ZL, Yan NH, Pang YG, Yuan M, Chen GJ, Xu GT, Zhang K, Yuan QL.

.

Neuroprotective effect of grafting GDNF gene-modified neural stem cells on cerebral ischemia in rats.

Brain Res.

2009 Aug 11;1284:1-11.

(IF 2.733)

106. Ding D, Huang P, Sun H, Xue Q, Pan Y, Chen S.

.

Identification of protein components and quantitative immunoassay for SEC2 in staphylococcin injection.

J PHARMACEUT BIOMED.

2009 Aug 15;50(1):79-85.

(IF 3.209)

107. Liu X, Shi S, Ye J, Liu L, Sun M, Wang C.

.

Effect of polypeptide from Chlamys farreri on UVB-induced ROS/NF-kappaB/COX-2 activation and apoptosis in HaCaT cells.

J PHOTOCH PHOTOBIO B.

2009 Aug 3;96(2):109-16.

(IF 4.383)

108. Zhang Z, Wang Q, Li P, Zhou Y, Li S, Yi W, Chen A, Kong P, Hu C.

.

Overexpression of the Interferon regulatory factor 4-binding protein in human colorectal cancer and its clinical significance.

Cancer Epidemiol.

2009 Aug;33(2):130-6.

(IF 2.179)

109. Ma K, Hu M, Qi Y, Qiu L, Jin Y, Yu J, Li B.

.

Structure-transfection activity relationships with glucocorticoid-polyethyl-enimine conjugate nuclear gene delivery systems.

Biomaterials.

2009 Aug;30(22):3780-9.

(IF 10.317)

110. Liao Z, Huang C, Zhou F, Xiong J, Bao J, Zhang H, Sun W, Xie C, Zhou Y.

.

Radiation enhances suicide gene therapy in radioresistant laryngeal squamous cell carcinoma via activation of a tumor-specific promoter.

Cancer Lett.

2009 Sep 28;283(1):20-8.

(IF 7.36)

111. Feng B, Huang CG, Chen RH, Guo YW, Jiao BH.

.

2'-Epi-2'-O-acetylthevetin B induces apoptosis partly via Ca(2+)-mediated mitochondrial pathway in human hepatocellular carcinoma HepG2 cells.

Cell Biol Int.

2009 Sep;33(9):918-25.

(IF 2.571)

112. Ye Y, Hu SJ, Li L.

.

Inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced hypertrophic responses in rat neonatal cardiomyocytes: involvement of the RhoA/Rho kinase pathway.

FEBS Lett.

2009 Sep 17;583(18):2997-3003.

(IF 3.057)

113. Shi GS, Ren LF, Wang LZ, Lin HS, Wang SB, Tong YQ.

.

H2O2/HCl and heat-treated Ti-6Al-4V stimulates pre-osteoblast proliferation and differentiation.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod.

2009 Sep;108(3):368-75.

(IF 0.27)

114. Chen Y, Wang J, Yao Y, Yuan W, Kong M, Lin Y, Geng D, Nie R.

.

CRP regulates the expression and activity of tissue factor as well as tissue factor pathway inhibitor via NF-kappaB and ERK 1/2 MAPK pathway.

FEBS Lett.

2009 Sep 3;583(17):2811-8.

(IF 3.057)

115. Chen WL, Qian Y, Meng WF, Pang JY, Lin YC, Guan YY, Chen SP, Liu J, Pei Z, Wang GL.

.

A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro.

Biochem Pharmacol.

2009 Oct 15;78(8):941-50.

(IF 4.96)

116. Ma K, Hu MX, Qi Y, Zou JH, Qiu LY, Jin Y, Ying XY, Sun HY.

.

PAMAM-triamcinolone acetonide conjugate as a nucleus-targeting gene carrier for enhanced transfer activity.

Biomaterials.

2009 Oct;30(30):6109-18.

(IF 10.317)

117. Hua W, Jiang J, Rong X, Wu R, Qiu H, Zhang Y, Chen Q.

.

The dual role of the cystathionine gamma-lyase/hydrogen sulfide pathway in CVB3-induced myocarditis in mice.

BIOCHEM BIOPH RES CO.

2009 Oct 23;388(3):595-600.

(IF 2.985)

118. Lin Y, Chen Y, Yang X, Xu D, Liang S.

.

Proteome analysis of a single zebrafish embryo using three different digestion strategies coupled with liquid chromatography-tandem mass spectrometry.

Anal Biochem.

2009 Nov 15;394(2):177-85.

(IF 2.877)

119. Xu Y, Ge R, Du J, Xin H, Yi T, Sheng J, Wang Y, Ling C.

.

Corosolic acid induces apoptosis through mitochondrial pathway and caspase activation in human cervix adenocarcinoma HeLa cells.

Cancer Lett.

2009 Nov 1;284(2):229-37.

(IF 7.36)

120. Li H, Zhang L, Huang Q.

.

Differential expression of mitogen-activated protein kinase signaling pathway in the hippocampus of rats exposed to chronic unpredictable stress.

Behav Brain Res.

2009 Dec 14;205(1):32-7.

(IF 2.977)

121. Wu W, Yan C, Gan T, Chen Z, Lu X, Duerksen-Hughes PJ, Zhu X, Yang J.

.

Nuclear proteome analysis of cisplatin-treated HeLa cells.

MUTAT RES-REV MUTAT.

2010;691(1-2):1-8.

(IF 5.803)

122. Gong HS, Meng XC, Wang H.

.

Plantaricin MG active against Gram-negative bacteria produced by Lactobacillus plantarum KLDS1.0391 isolated from"Jiaoke", a traditional fermented cream from China.

Food Control.

21 (2010) 89–96.

(IF 4.258)

123. Li F, Gong QH, Wu Q, Lu YF, Shi JS.

.

Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats.

PHARMACOL BIOCHEM BE.

2010;96(3):301-5.

(IF 2.519)

124. Li H, Fong C, Chen Y, Cai G, Yang M.

.

beta2- and beta3-, but not beta1-adrenergic receptors are involved in osteogenesis of mouse mesenchymal stem cells via cAMP/PKA signaling.

Arch Biochem Biophys.

2010 15;496(2):77-83.

(IF 3.391)

125. Han J, Zhou YP, Jiang YZ, He YT, Mei F.

.

Postnatal development of interstitial cells of Cajal in mouse colon in response to Kit signal blockade with Imatinib (Glivec).

Acta Histochem.

2010;112(3):215-21.

(IF 2.107)

126. Feng B, Guo YW, Huang CG, Li L, Chen RH, Jiao BH.

.

2'-epi-2'-O-Acetylthevetin B extracted from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.

CHEM-BIOL INTERACT.

2010;183(1):142-53.

(IF 3.723)

127. Qin XL, Bi HC, Wang XD, Li JL, Wang Y, Xue XP, Chen X, Wang CX, Xu le J, Wang YT, Huang M.

.

Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506).

INT J PHARMACOL.

2010;389(1-2):114-21.

(IF 0.692)

128. Lin Y, Xu J, Cao L, Han Y, Gao J, Xie N, Zhao X, Jiang H, Chi Z.

.

Mitochondrial base excision repair pathway failed to respond to status epilepticus induced by pilocarpine.

Neurosci Lett.

2010;474(1):22-5.

(IF 2.274)

129. Li Q, Wu D, Zhang L, Zhang Y.

.

Effects of galantamine on β-amyloid release and beta-site cleaving enzyme 1 expression in differentiated human neuroblastoma SH-SY5Y cells.

Exp Gerontol.

2010;45(11):842-7.

(IF 3.376)

130. Li GG, Liang XF, Xie Q, Li G, Yu Y, Lai K.

.

Gene structure, recombinant expression and functional characterization of grass carp leptin.

GEN COMP ENDOCR.

2010;166(1):117-27.

(IF 2.426)

131. Zhao L, Wang X, Chang Q, Xu J, Huang Y, Guo Q, Zhang S, Wang W, Chen X, Wang J.

.

Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis.

Eur J Pharmacol.

2010;627(1-3):304-12.

(IF 3.263)

132. He F, Zhang F, Yang G, Wang X, Zhao S.

.

Enhanced initial proliferation and differentiation of MC3T3-E1 cells on HF/HNO3 solution treated nanostructural titanium surface.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod.

2010;110(4):e13-22.

(IF 0.27)

133. Yan J, Sun XB, Wang HQ, Zhao H, Zhao XY, Xu YX, Guo JC, Zhu CQ.

.

Chronic restraint stress alters the expression and distribution of phosphorylated tau and MAP2 in cortex and hippocampus of rat brain.

Brain Res.

2010;1347:132-41.

(IF 2.733)

134. Song XZ, Xu JQ, Wang T, Liu FH.

.

Traditional Chinese medicine decoction enhances growth performance and intestinal glucose absorption in heat stressed pigs by up-regulating the expressions of SGLT1 and GLUT2 mRNA.

Livestock Science.

2010;128:75–81.

(IF 1.376)

135. Yuan H, Zhang W, Du YZ, Hu FQ.

.

Ternary nanoparticles of anionic lipid nanoparticles/protamine/DNA for gene delivery.

INT J PHARMACOL.

2010;392(1-2):224-31.

(IF 0.692)

136. Yu Q, Zhao Z, Sun J, Guo W, Fu J, Burnstock G, He C, Xiang Z.

.

Expression of P2X6 receptors in the enteric nervous system of the rat gastrointestinal tract.

Histochem Cell Biol.

2010;133(2):177-88.

(IF 3.418)

137. Hu H, Zhang Y, Zou M, Yang S, Liang XQ.

.

Expression of TRF1, TRF2, TIN2, TERT, KU70, and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric cancer.

J CANCER RES CLIN.

2010;136(9):1407-14.

(IF 3.656)

138. Ding XL, Wang YH, Ning LP, Zhang Y, Ge HY, Jiang H, Wang R, Yue SW.

.

Involvement of TRPV4-NO-cGMP-PKG pathways in the development of thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats.

Behav Brain Res.

2010;208(1):194-201.

(IF 2.977)

139. Huang LH, Hu JQ, Tao WQ, Li YH, Li GM, Xie PY, Liu XS, Jiang J.

.

Gossypol inhibits phosphorylation of Bcl-2 in human leukemia HL-60 cells.

Eur J Pharmacol.

2010;645(1-3):9-13.

(IF 3.263)

140. Sun J, Liu X, Li Q.

.

Molecular cloning, expression and antioxidant activity of a peroxiredoxin 2 homologue from Lampetra japonica.

FISH SHELLFISH IMMUN.

2010;28(5-6):795-801.

(IF 3.298)

141. Wang S, Liu S, Liu H, Wang J, Zhou S, Jiang RJ, Bendena WG, Li S.

.

20-hydroxyecdysone reduces insect food consumption resulting in fat body lipolysis during molting and pupation.

J Mol Cell Biol.

2010;2(3):128-38.

(IF 4.0)

142. Cao BY, Yang YP, Luo WF, Mao CJ, Han R, Sun X, Cheng J, Liu CF.

.

Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway.

J Ethnopharmacol.

2010;131(1):122-9.

(IF 3.69)

143. Liu J, Wang A, Li L, Huang Y, Xue P, Hao A.

.

Oxidative stress mediates hippocampal neuron death in rats after lithium-pilocarpine- induced status epilepticus.

SEIZURE-EUR J EPILEP.

2010;19(3):165-72.

(IF 2.522)

144. Li C, Xing G, Dong M, Zhou L, Li J, Wang G, Zou D, Wang R, Liu J, Niu Y.

.

Beta-asarone protection against beta-amyloid-induced neurotoxicity in PC12 cells via JNK signaling and modulation of Bcl-2 family proteins.

Eur J Pharmacol.

2010;635(1-3):96-102.

(IF 3.263)

145. Zhou CL, Yu XJ, Chen LM, Jiang H, Li CY.

.

Corticotropin-releasing hormone attenuates vascular endothelial growth factor release from human HaCaT keratinocytes.

REGUL PEPTIDES.

2010 Feb 25;160(1-3):115-20.

(IF 1.813)

146. Chen S, Chen Y, Hu C, Jing H, Cao Y, Liu X.

.

Association of clinicopathological features with UbcH10 expression in colorectal cancer.

J CANCER RES CLIN.

2010 Mar;136(3):419-26.

(IF 3.656)

147. Wu GJ, Zhou LZ, Wang KW, Chen F, Sun Y, Duan YR, Zhu YJ, Gu HC.

.

Hydroxylapatite nanorods: An efficient and promising carrier for gene transfection.

J COLLOID INTERF SCI.

2010 May 15;345(2):427-32.

(IF 7.489)

148. Wang YX, Xu XY, Su WL, Wang Q, Zhu WX, Chen F, Jin G, Liu YJ, Li YD, Sun YP, Gao WC, Ruan CP.

.

Activation and Clinical Significance of p38 MAPK Signaling Pathway in Patients With Severe Trauma.

J Surg Res.

2010 Jun 1;161(1):119-25.

(IF 1.841)

149. Yuan D, Pan Y, Zhang J, Shao C.

.

Role of nuclear factor-kappaB and P53 in radioadaptive response in Chang live cells.

MUTAT RES-REV MUTAT.

2010 Jun 1;688(1-2):66-71.

(IF 5.803)

150. Zhang JC, Liu CL, Li YP, Sun J, Wang P, Di KQ, Chen H, Zhao YY .

.

Effect of yttrium ion on the proliferation, differentiation and mineralization function of primary mouse osteoblasts in vitro.

Journal Of Rare Earths.

2010 Jun;28(3):466-470.

(IF 2.846)

151. Sun H, Li QW, Lv XY, Ai JZ, Yang QT, Duan JJ, Bian GH, Xiao Y, Wang YD, Zhang Z, Liu YH, Tan RZ, Yang Y, Wei YQ, Zhou Q.

.

MicroRNA-17 post-transcriptionally regulates polycystic kidney disease-2 gene and promotes cell proliferation.

Mol Biol Rep.

2010 Jul;37(6):2951-6.

(IF 1.402)

152. Zhu J, Zhang L, Jin X, Han X, Sun C, Yan J.

.

beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway.

Mol Biol Rep.

2010 Jul;37(6):2653-63.

(IF 1.402)

153. Wang S, Lv X, Zhang K, Lin T, Liu X, Yuan J, Dai Y, Li N.

.

Knockdown of the prion gene expression by RNA interference in bovine fibroblast cells.

Mol Biol Rep.

2010 Oct;37(3):3193-8.

(IF 1.402)

154. Deng X, Cheng J, Zhang Y, Li N, Chen L.

.

Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats.

Acta Diabetol.

2010 Dec;47(1):177-85.

(IF 3.418)

155. Zhao L, Yang R, Cheng L, Wang M, Jiang Y, Wang S.

.

LPS-Induced Epithelial-Mesenchymal Transition of Intrahepatic Biliary Epithelial Cells.

J Surg Res.

2010 Dec;171(2):819-25.

(IF 1.841)

156. Chen Z, Liu S, Sumida T, Sun S, Wei Y, Liu M, Dong Z, Zhang F, Hamakawa H, Wei F.

.

Silencing Id-1 with RNA Interference Inhibits Adenoid Cystic Carcinoma in Mice.

J Surg Res.

2011 Jul;169(1):57-66.

(IF 1.841)

157. Zhang L, Jiang G, Yao F, He Y, Liang G, Zhang Y, Hu B, Wu Y, Li Y, Liu H.

.

Growth inhibition and apoptosis induced by osthole, a natural coumarin, in hepatocellularcarcinoma.

PLoS One.

2012;7(5):e37865.

(IF 2.74)

158. Xiao O, Xie ZL, Lin BW, Yin XF, Pi RB, Zhou SY.

.

Minocycline inhibits alkali burn-induced corneal neovascularization in mice.

PLoS One.

2012;7(7):e41858.

(IF 2.74)

159. Jiang L, Lin J, Han H, Dong H, Zhao Q, Zhu S, Huang B.

.

Identification and Characterization of Eimeria tenella Apical Membrane Antigen-1 (AMA1).

PLoS One.

2012;7(7):e41115.

(IF 2.74)

160. Zhang YS, He L, Liu B, Li NS, Luo XJ, Hu CP, Ma QL, Zhang GG, Li YJ, Peng J.

.

A novel pathway of NADPH oxidase/vascular peroxidase 1 in mediating oxidative injury followingischemia-reperfusion.

Basic Res Cardiol.

2012;107(3):266.

(IF 11.981)

161. Wu J, Lai G, Wan F, Xiao Z, Zeng L, Wang X, Ye F, Lei T.

.

Knockdown of checkpoint kinase 1 is associated with the increased radiosensitivity ofglioblastoma stem-like cells.

Tohoku J Exp Med.

2012;226(4):267-74.

(IF 1.441)

162. Liu P, Shi Y, Yang Y, Cao Y, Shi Y, Li H, Liu J, Lin J, Jin Y.

.

Schistosoma Japonicum UDP-Glucose 4-Epimerase Protein Is Located on the Tegument andInduces Moderate Protection against Challenge Infection.

PLoS One.

2012;7(7):e42050.

(IF 2.74)

163. Du HM, Zheng XH, Wang LY, Tang W, Liu L, Jing W, Lin YF, Tian WD, Long J.

.

The Osteogenic Response of Undifferentiated Human Adipose-Derived Stem Cells underMechanical Stimulation.

Cells Tissues Organs.

2012;196(4):313-24.

(IF 2.064)

164. Wang Y, Xie S, Liu C, Wu Y, Liu Y, Cai Y.

.

Inhibitory effect of liquiritigenin on migration via downregulation proMMP-2 and PI3K/Akt signalingpathway in human lung adenocarcinoma A549 cells.

Nutr Cancer.

2012;64(4):627-34.

(IF 2.363)

165. Song Z, Li Y, Liu Y, Xin J, Zou X, Sun W.

.

α-Enolase, an Adhesion-Related Factor of Mycoplasma bovis.

PLoS One.

2012;7(6):e38836.

(IF 2.74)

166. Baohua Y, Li L.

.

Effects of SIRT6 silencing on collagen metabolism in human dermal fibroblasts.

Cell Biol Int.

2012 Jan;36(1):105-8.

(IF 2.571)

167. Li Y, Wang J, Grebogi C, Foote M, Liu F.

.

A syringe-focused ultrasound device for simultaneous injection of DNA and gene transfer.

J Gene Med.

2012 Jan;14(1):54-61.

(IF 3.258)

168. Zhong Y, Liu T, Guo Z.

.

Curcumin inhibits ox-LDL-induced MCP-1 expression by suppressing the p38MAPK and NF-κBpathways in rat vascular smooth muscle cells.

Inflamm Res.

2012 Jan;61(1):61-7.

(IF 3.174)

169. Liang G, Chen H, Zhang S, Wu W, Kong J.

.

Magnetic nanosensors for highly sensitive and selective detection of bacillus Calmette-Guérin.

Analyst.

2012 Feb 7;137(3):675-9.

(IF 3.978)

170. Li XJ, Liu DP, Chen HL, Pan XH, Kong QY, Pang QF.

.

Lactoferrin protects against lipopolysaccharide-induced acute lung injury in mice.

Int Immunopharmacol.

2012 Feb;12(2):460-4.

(IF 3.943)

171. Han X, Lu M, Wang S, Lv D, Liu H.

.

Targeting IKK/NF-κB pathway reduces infiltration of inflammatory cells and apoptosis after spinalcord injury in rats.

Neurosci Lett.

2012 Mar 5;511(1):28-32.

(IF 2.274)

172. Zhang X, Xu Y, Wang J, Zhou Q, Pu S, Jiang W, Du D.

.

The effect of intrathecal administration of glial activation inhibitors on dorsal horn BDNFoverexpression and hind paw mechanical allodynia in spinal nerve ligated rats.

J Neural Transm.

2012 Mar;119(3):329-36.

(IF 3.505)

173. Zhao S, Zhao G, Xie H, Huang Y, Hou Y.

.

A conjugate of an anti-midkine single-chain variable fragment to doxorubicin inhibits tumorgrowth.

Braz J Med Biol Res.

2012 Mar;45(3):230-7.

(IF 2.023)

174. Yu SJ, Liu HC, Ling-Ling E, Wang DS, Zhu GX.

.

Proliferation and differentiation of osteoblasts from the mandible of osteoporotic rats.

EXP BIOL MED.

2012 Apr;237(4):395-406.

(IF 3.139)

175. Wang T, Fu F, Han B, Zhang L, Zhang X.

.

Danshensu ameliorates the cognitive decline in streptozotocin-induced diabetic mice byattenuating advanced glycation end product-mediated neuroinflammation.

J Neuroimmunol.

2012 Apr;245(1-2):79-86.

(IF 3.125)

176. Liu M, Zhou G, Song W, Li P, Liu H, Niu X, Fan Y.

.

Effect of nano-hydroxyapatite on the axonal guidance growth of rat cortical neurons.

Nanoscale.

2012 May 21;4(10):3201-7.

(IF 6.895)

177. Xu MF, Xiong YY, Liu JK, Qian JJ, Zhu L, Gao J.

.

Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitivedeficits in mice and apoptosis in SH-SY5Y cells.

Acta Pharmacol Sin.

2012 May;33(5):578-87.

(IF 5.064)

178. Yu H, Li Q, Zhou X, Kolosov VP, Perelman JM.

.

Transient receptor potential vanilloid 1 receptors mediate acid-induced mucin secretion via Ca2+influx in human airway epithelial cells.

J BIOCHEM MOL TOXIC.

2012 May;26(5):179-86.

(IF 3.606)

179. Zuo K, Li D, Pulli B, Yu F, Cai H, Yuan X, Zhang X, Lv Z.

.

Short-hairpin RNA-mediated Heat shock protein 90 gene silencing inhibits human breast cancercell growth in vitro and in vivo.

BIOCHEM BIOPH RES CO.

2012 May 4;421(2):396-402.

(IF 2.985)

180. Chen M, Hu M, Wang D, Wang G, Zhu X, Yan D, Sun J.

.

Multifunctional Hyperbranched Glycoconjugated Polymers Based on Natural Aminoglycosides.

BIOCONJUGATE CHEM.

2012 Jun 20;23(6):1189-99.

(IF 4.031)

181. Sun D, Wang Y, Liu C, Zhou X, Li X, Xiao A.

.

Effects of nitric oxide on renal interstitial fibrosis in rats with unilateral ureteral obstruction.

Life Sci.

2012 Jun 14;90(23-24):900-9.

(IF 3.647)

182. Zhao XY, Zhu YJ, Chen F, Wu J.

.

Calcium phosphate nanocarriers dual-loaded with bovine serum albumin and Ibuprofen: facilesynthesis, sequential drug loading and sustained drug release.

CHEM-ASIAN J.

2012 Jun;7(7):1610-5.

(IF 4.056)

183. Yang L, Cheng F, Liu T, Lu JR, Song K, Jiang L, Wu S, Guo W.

.

Comparison of mesenchymal stem cells released from poly(N-isopropylacrylamide) copolymerfilm and by trypsinization.

Biomed Mater.

2012 Jun;7(3):035003.

(IF 3.174)

184. Sun X, Cheng F, Meng B, Yang B, Song W, Yuan H.

.

Pregnenolone sulfate decreases intraocular pressure and changes expression of sigma receptorin a model of chronic ocular hypertension.

Mol Biol Rep.

2012 Jun;39(6):6607-14.

(IF 1.402)

185. Ren M, Qin D, Li K, Qu J, Wang L, Wang Z, Huang A, Tang H.

.

Correlation between hepatitis B virus protein and microRNA processor Drosha in cells expressingHBV.

ANTIVIR RES.

2012 Jun;94(3):225-31.

(IF 4.101)

186. Yang XH, Wang YH, Wang JJ, Liu YC, Deng W, Qin C, Gao JL, Zhang LY.

.

Role of angiotensin-converting enzyme (ACE and ACE2) imbalance on tourniquet-induced remotekidney injury in a mouse hindlimb ischemia-reperfusion model.

Peptides.

2012 Jul;36(1):60-70.

(IF 2.843)

187. Li TT, Zhang YS, He L, Liu B, Shi RZ, Zhang GG, Peng J.

.

Inhibition of vascular peroxidase alleviates cardiac dysfunction and apoptosis induced by ischemia-reperfusion.

CAN J PHYSIOL PHARM.

2012 Jul;90(7):851-62.

(IF 1.946)

188. Zhang Y, Xu Y, Zhu Q, Zhao F, Luo J, Zhang X, Wang X.

.

Upregulation of dysbindin in temporal lobe epileptic foci of human and experimental animals.

Synapse.

2012 Jul;66(7):622-9.

(IF 2.318)

189. Huang Q, Deng J, Xie Z, Wang F, Chen S, Lei B, Liao P, Huang N, Wang Z, Wang Z, Cheng Y.

.

Effective gene transfer into central nervous system following ultrasound-microbubbles-inducedopening of the blood-brain barrier.

Ultrasound Med Biol.

2012 Jul;38(7):1234-43.

(IF 2.514)

190. Zhong X, Li W, Huang X, Zhang L, Yimamu M, Raiput N, Zhou Y, Wang T.

.

Impairment of cellular immunity is associated with overexpression of heat shock protein 70 inneonatal pigs with intrauterine growth retardation.

CELL STRESS CHAPERON.

2012 Jul;17(4):495-505.

(IF 2.892)

191. Sang H, Zhang L, Li J.

.

Anti-benzopyrene-7,8-diol-9,10-epoxide induces apoptosis via mitochondrial pathway in humanbronchiolar epithelium cells independent of the mitochondria permeability transition pore.

Food Chem Toxicol.

2012 Jul;50(7):2417-23.

(IF 4.679)

192. Hao M, Kuang HY, Fu Z, Gao XY, Liu Y, Deng W.

.

Exenatide prevents high-glucose-induced damage of retinal ganglion cells through a mitochondrialmechanism.

Neurochem Int.

2012 Jul;61(1):1-6.

(IF 3.881)

193. Jiang H, Yuan H, Liang Y, Xia S, Zhao Q, Wu Q, Zhang L, Liang Z, Zhang Y.

.

A hydrophilic immobilized trypsin reactor with N-vinyl-2-pyrrolidinone modified polymermicroparticles as matrix for highly efficient protein digestion with low peptide residue.

J Chromatogr A.

2012 Jul 13;1246:111-6.

(IF 4.049)

194. Xiong W, Luo Y, Zhang C, Tan D, Zuo S.

.

Expression, Purification of Recombinant Human Mitochondrial Transcription TerminationFactor 3(hMTERF3) and Preparation of Polyclonal Antibody Against hMTERF3.

APPL BIOCHEM BIOTECH.

2012 Aug;167(8):2318-29.

(IF 2.277)

195. Zhang L, Ding W, Sun H, Zhou Q, Huang J, Li X, Xie Y, Chen J.

.

Salidroside protects PC12 cells from MPP(+)-induced apoptosis via activation of the PI3K/Akt pathway.

Food Chem Toxicol.

2012 Aug;50(8):2591-7.

(IF 4.679)

196. Zhang Q, He QF, Zhang TH, Yu XL, Liu Q, Deng FL.

.

Improvement in the delivery system of bone morphogenetic protein-2: a new approach to promotebone formation.

Biomed Mater.

2012 Aug;7(4):045002.

(IF 3.174)

197. Fauzee NJ, Wang YL, Dong Z, Li QG, Wang T, Mandarry MT, Xu L, Pan J.

.

Novel hydrophilic docetaxel (CQMU-0519) analogue inhibits proliferation and induces apoptosis inhuman A549 lung, SKVO3 ovarian and MCF7 breast carcinoma cell lines.

CELL PROLIFERAT.

2012 Aug;45(4):352-64.

(IF 5.753)

198. Lin N, Chen H, Zhang H, Wan X, Su Q.

.

Mitochondrial reactive oxygen species (ROS) inhibition ameliorates palmitate-induced INS-1 betacell death.

Endocrine.

2012 Aug;42(1):107-17.

(IF 3.235)

199. Liu W, Li N.

.

Chicken sine oculis binding protein homolog (sobp), a novel gene that may regulate feather development.

J POULT SCI.

2012 Aug;91(8):1950-5.

(IF 0.88)

200. Zhou H, Chen ZB, Tian HQ, Xu X, Wang YQ, Xing GQ, Cheng L.

.

Effects of hypoxia-inducible factor 1α on bone conduction impairment in otitis media with effusion.

ACTA OTO-LARYNGOL.

2012 Sep;132(9):938-43.

(IF 1.157)

201. Song Z, Liu L, Yue Y, Jiao H, Lin H, Sheikhahmadi A, Everaert N, Decuypere E, Buyse J.

.

Fasting alters protein expression of AMP-activated protein kinase in the hypothalamus of broilerchicks (Gallus gallus domesticus).

GEN COMP ENDOCR.

2012 Sep 15;178(3):546-55.

(IF 2.426)

202. Liu H, Chen X, Gao W, Jiang G.

.

The expression of heparanase and microRNA-1258 in human non-small cell lung cancer.

TUMOR BIOL .

2012 Oct;33(5):1327-34.

(IF 3.65)

203. Zhao P, Han T, Guo JJ, Zhu SL, Wang J, Ao F, Jing MZ, She YL, Wu ZH, Ye LB.

.

HCV NS4B induces apoptosis through the mitochondrial death pathway.

Virus Res.

2012 Oct;169(1):1-7.

(IF 2.934)

204. Hu B, Zhou H, Gao H, Liu Y, Yan T, Zou L, Chen L.

.

IFN-γ Inhibits Osteopontin Expression in Human Decidual Stromal Cells and can be Attenuated by 1α,25-Dihydroxyvitamin D3.

Am J Reprod Immunol.

2012 Oct;68(4):353-61.

(IF 2.739)

205. Zhang Y, Zhou L, Zhang X, Bai J, Shi M, Zhao G.

.

Ginsenoside-Rd attenuates TRPM7 and ASIC1a but promotes ASIC2a expression in rats after focalcerebral ischemia.

Neurol Sci.

2012 Oct;33(5):1125-31.

(IF 2.415)

206. Bi WY, Fu BD, Shen HQ, Wei Q, Zhang C, Song Z, Qin QQ, Li HP, Lv S, Wu SC, Yi PF, Wei XB.

.

Sulfated Derivative of 20(S)-Ginsenoside Rh2 Inhibits Inflammatory Cytokines Through MAPKs andNF-kappa B Pathways in LPS-Induced RAW264.7 Macrophages.

Inflammation.

2012 Oct;35(5):1659-68.

(IF 3.212)

207. Tian J, Yan J, Wang W, Zhong N, Tian L, Sun J, Min Z, Ma J, Lu S.

.

T-2 toxin enhances catabolic activity of hypertrophic chondrocytes through ROS-NF-κB-HIF-2αpathway.

Toxicol In Vitro.

2012 Oct 26(7):1106-13.

(IF 2.959)

208. Chen X, Yang X, Liu T, Guan M, Feng X, Dong W, Chu X, Liu J, Tian X, Ci X, Li H, Wei J, Deng Y, Deng X, Chi G, Sun Z.

.

Kaempferol regulates MAPKs and NF-κB signaling pathways to attenuate LPS-induced acute lunginjury in mice.

Int Immunopharmacol.

2012 Oct;14(2):209-16.

(IF 3.943)

209. Li XY, Jing CQ, Zang XY, Yang S, Wang JJ.

.

Toxic cytological alteration and mitochondrial dysfunction in PC12 cells induced by 1-octyl-3-methylimidazolium chloride.

Toxicol In Vitro.

2012 Oct;26(7):1087-92.

(IF 2.959)

210. Ding Y, Huang X, Liu T, Fu Y, Tan Z, Zheng H, Zhou T, Dai J, Xu W.

.

The Plasmodium Circumsporozoite Protein, a Novel NF-κB Inhibitor, Suppresses the Growth ofSW480.

Pathol Oncol Res.

2012 Oct;18(4):895-902.

(IF 2.826)

211. Zhu XB, Wang YB, Chen O, Zhang DQ, Zhang ZH, Cao AH, Huang SY, Sun RP.

.

Characterization of the expression of macrophage inflammatory protein-1α (MIP-1α) andchemokine receptor CCR5 after kainic acid-induced status epilepticus (SE) in juvenile rats.

NEUROPATH APPL NEURO.

2012 Oct;38(6):602-16.

(IF 7.5)

212. Lu N, Liu Q, Li R, Xie L, Shen J, Guan W, Qian X, Yu L, Ding Y, Jiang X, Liu B.

.

Superior antimetastatic effect of pemetrexed-loaded gelatinase-responsive nanoparticles in amouse metastasis model.

ANTI-CANCER DRUG.

2012 Nov;23(10):1078-88.

(IF 2.26)

213. Zhou YM, Zhang XF, Cao L, Li B, Sui CJ, Li YM, Yin ZF

.

MCM7 expression predicts post-operative prognosis for hepatocellular carcinoma.

Liver Int.

2012 Nov;32(10):1505-9.

(IF 5.175)

214. Jia P, Xu YJ, Zhang ZL, Li K, Li B, Zhang W, Yang H.

.

Ferric ion could facilitate osteoclast differentiation and bone resorption through the production ofreactive oxygen species.

J Orthop Res.

2012 Nov;30(11):1843-52.

(IF 2.728)

215. Tang X, Liu J, Dong W, Li P, Li L, Lin C, Zheng Y, Hou J, Li D.

.

The cardioprotective effects of citric Acid and L-malic Acid on myocardial ischemia/reperfusion injury.

EVID-BASED COMPL ALT.

2013;2013:820695.

(IF 1.813)

216. Liu X, Wang M, Chen H, Guo Y, Ma F, Shi F, Bi Y, Li Y.

.

Hypothermia protects the brain from transient global ischemia/reperfusion by attenuating endoplasmic reticulum response-induced apoptosis through CHOP.

PLoS One.

2013;8(1):e53431.

(IF 2.74)

217. Jin R, Zhu W, Cao S, Chen R, Jin H, Liu Y, Wang S, Wang W, Xiao G.

.

Japanese encephalitis virus activates autophagy as a viral immune evasion strategy.

PLoS One.

2013;8(1):e52909.

(IF 2.74)

218. Feng Q, Gou XJ, Meng SX, Huang C, Zhang YQ, Tang YJ, Wang WJ, Xu L, Peng JH, Hu YY.

.

Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein Kinase In Vivoand In Vitro.

EVID-BASED COMPL ALT.

2013;2013:184358.

(IF 1.813)

219. Zhang L, Xiao R, Xiong J, Leng J, Ehtisham A, Hu Y, Ding Q, Xu H, Liu S, Wang J, Tang DG, Zhang Q.

.

Activated ERM protein plays a critical role in drug resistance of MOLT4 cells induced by CCL25.

PLoS One.

2013;8(1):e52384.

(IF 2.74)

220. Hu L, Wu QQ, Wang WB, Jiang HG, Yang L, Liu Y, Yu HJ, Xie CH, Zhou YF, Zhou FX.

.

Suppression of Ku80 Correlates with Radiosensitivity and Telomere Shortening in the U2OS Telomerase-negativeOsteosarcoma Cell Line.

ASIAN PAC J CANCER P .

2013;14(2):795-9.

(IF 1.24)

221. Wang M, Wang J, Tan R, Wu Q, Qiu H, Yang J, Jiang Q.

.

Effect of Berberine on PPAR α /NO Activation in High Glucose- and Insulin-Induced Cardiomyocyte Hypertrophy.

EVID-BASED COMPL ALT.

2013;2013:285489.

(IF 1.813)

222. Chen X, Gu M, Zhao X, Zheng X, Qin Y, You X.

.

Deterioration of cardiac function after acute myocardial infarction is prevented by transplantation of modified endothelial progenitor cells overexpressing endothelial NO synthases.

CELL PHYSIOL BIOCHEM.

2013;31(2-3):355-65.

(IF 5.5)

223. Gao M, Wu M, Song Y, Jin L, Lou J, Tao H.

.

PCB153-induced oxidative stress and cell apoptosis on cultured rat Sertoli cells.

Toxicology Research.

2013;3:173-9.

(IF 1.593)

224. Lian LH, Jin Q, Song SZ, Wu YL, Bai T, Jiang S, Li Q, Yang N, Nan JX.

.

Ginsenoside Rh2 Downregulates LPS-Induced NF- κ B Activation through Inhibition of TAK1 Phosphorylation inRAW 264.7 Murine Macrophage.

EVID-BASED COMPL ALT.

2013;2013:646728.

(IF 1.813)

225. Liu Z, Zhang J, Huang X, Huang L, Li S, Wang Z.

.

Magnesium sulfate inhibits the secretion of high mobility group box 1 from lipopolysaccharide-activated RAW264.7 macrophages in vitro.

J Surg Res.

2013 Jan;179(1):e189-95.

(IF 1.841)

226. Zhu C, Wang Q, Xie J, Shi J, Zhou X, Li D, Xiong F, Zhang L.

.

Expression and Significance of RKIP and E-cadherin in Lung Squamous Cell Carcinoma.

Pathol Oncol Res.

2013 Jan;19(1):19-26.

(IF 2.826)

227. Qiu L, Chen Y, Gao M, Zheng C, Zhao Q.

.

Phagocytic uptake and ROS-mediated cytotoxicity in human hepatic cell line of amphiphilic polyphosphazenenanoparticles.

J Biomed Mater Res A.

2013 Jan;101(1):285-97.

(IF 3.525)

228. Tang XQ, Zhuang YY, Zhang P, Fang HR, Zhou CF, Gu HF, Zhang H, Wang CY.

.

Formaldehyde impairs learning and memory involving the disturbance of hydrogen sulfide generation in thehippocampus of rats.

J Mol Neurosci.

2013 Jan;49(1):140-9.

(IF 2.678)

229. Zou Y, Hong B, Fan L, Zhou L, Liu Y, Wu Q, Zhang X, Dong M.

.

Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathway.

FREE RADICAL RES.

2013 Jan;47(1):55-63.

(IF 2.839)

230. Ding J, Li QY, Yu JZ, Wang X, Lu CZ, Ma CG, Xiao BG.

.

Carbamylated erythropoietin ameliorates hypoxia-induced cognitive and behavioral defects with the generation ofcholine acetyltransferase-positive neurons.

J Neurosci Res.

2013 Jan;91(1):73-82.

(IF 4.699)

231. Gu Y, Zhao Y, Gong L, Wang Y, Zhang Y.

.

Potassium aspartate attenuates apoptotic cell death after focal cerebral ischemia in rats.

Biomedicine & Aging Pathology.

2013 Jan-Mar;3(1):14–19.

232. Duan S, Yang X, Mao J, Qi B, Cai Q, Shen H, Yang F, Deng X, Wang S.

.

Osteocompatibility evaluation of poly(glycine ethyl ester-co-alanine ethyl ester)phosphazene with honeycomb-patterned surface topography.

J Biomed Mater Res A.

2013 Feb;101(2):307-17.

(IF 3.525)

233. Jia F, Fan J, Zhang B, Yuan Z.

.

Mutagenesis of D80-82 and G83 residues in West Nile Virus NS2B: effects on NS2B-NS3 activity and viralreplication.

Virol Sin.

2013 Feb;28(1):16-23.

(IF 3.242)

234. Chen Y, Huang C, Bai C, Gao H, Ma R, Liu X, Dong Q.

.

Benzo[α]pyrene repressed DNA mismatch repair in human breast cancer cells.

Toxicology.

2013 Feb 8;304:167-72.

(IF 4.099)

235. Xie B, Zhou J, Shu G, Liu DC, Zhou J, Chen J, Yuan L.

.

Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumorsuppressive role of klotho in gastric cancer.

Cancer Cell Int.

2013 Feb 21;13(1):18.

(IF 4.175)

236. Bai T, Lian LH, Wu YL, Wan Y, Nan JX.

.

Thymoquinone attenuates liver fibrosis via PI3K and TLR4 signaling pathways in activated hepatic stellate cells.

Int Immunopharmacol.

2013 Feb;15(2):275-81.

(IF 3.943)

237. Liu H, Wu Z, Shi X, Li W, Liu C, Wang D, Ye X, Liu L, Na J, Cheng H, Chen L.

.

Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryocompaction.

Dev Biol.

2013 Mar 1;375(1):13-22.

(IF 2.895)

238. Zhang H, Wang ZW, Wu HB, Li Z, Li LC, Hu XP, Ren ZL, Li BJ, Hu ZP.

.

Transforming growth factor-β1 induces matrix metalloproteinase-9 expression in rat vascular smooth muscle cellsvia ROS-dependent ERK-NF-κB pathways.

Mol Cell Biochem.

2013 Mar;375(1-2):11-21.

(IF 2.795)

239. Dong X, Wang G, Zhang G, Ni Z, Suo J, Cui J, Cui A, Yang Q, Xu Y, Li F.

.

The endothelial lipase protein is promising urinary biomarker for diagnosis of gastric cancer.

Diagn Pathol.

2013 Mar 19;8:45.

(IF 2.335)

240. Yang T, Li C, Zhang L, Li M, Zhou P.

.

A promising hepatocyte-like cell line, CCL-13, exhibits good liver function both in vitro and in an acute liver failuremodel.

TRANSPL P.

2013 Mar;45(2):688-94.

(IF 0.784)

241. Sui Z, Yuan H, Liang Z, Zhao Q, Wu Q, Xia S, Zhang L, Huo Y, Zhang Y.

.

An activity-maintaining sequential protein extraction method for bioactive assay and proteome analysis of velvetantlers.

Talanta.

2013 Mar 30;107:189-94.

(IF 5.339)

242. Hu X, Yang T, Li C, Zhang L, Li M, Huang W, Zhou P.

.

Human fetal hepatocyte line, L-02, exhibits good liver function in vitro and in an acute liver failure model.

TRANSPL P.

2013 Mar;45(2):695-700.

(IF 0.784)

243. Jin J, Zhao WC, Yuan F.

.

CXCR7/CXCR4/CXCL12 Axis Regulates the Proliferation, Migration, Survival and Tube Formation of Choroid-Retinal Endothelial Cells.

Ophthalmic Res.

2013 Mar 21;50(1):6-12.

(IF 1.961)

244. Yin Y, Liu W, Ji G, Dai Y.

.

The essential role of p38 MAPK in mediating the interplay of oxLDL and IL-10 in regulating endothelial cellapoptosis.

Eur J Cell Biol.

2013 Apr-May;92(4-5):150-9.

(IF 3.025)

245. Jia QA, Wang ZM, Ren ZG, Bu Y, Xie XY, Wang YH, Zhang L, Zhang QB, Xue TC, Deng LF, Tang ZY.

.

Herbal compound "Songyou Yin" attenuates hepatoma cell invasiveness and metastasis through downregulationof cytokines secreted by activated hepatic stellate cells.

BMC COMPLEM ALTERN M.

2013 Apr 27;13:89.

(IF 2.833)

246. ITan Z, Zhu R, Shi R, Zhong J, Ma Y, Wang C, Wang X, Cheng N.

.

Involvement of rat organic cation transporter 2 in the renal uptake of jatrorrhizine.

EUR J PHARM SCI.

2013 Apr;102(4):1333-42.

(IF 3.616)

247. Hu J, Wu Q, Li T, Chen Y, Wang S.

.

Inhibition of high glucose-induced VEGF release in retinal ganglion cells by RNA interference targeting G protein-coupled receptor 91.

Exp Eye Res.

2013 Apr;109:31-9.

(IF 3.011)

248. Wang J, Cui J, Zhu H.

.

Suppression of type I collagen in human scleral fibroblasts treated with extremely low-frequency electromagneticfields.

Mol Vis.

2013 Apr 12;19:885-93.

(IF 2.202)

249. Wang Y, Li B, Li Z, Huang S, Wang J, Sun R.

.

Improvement of hypoxia-ischemia-induced white matter injury in immature rat brain by ethyl pyruvate.

Neurochem Res.

2013 Apr;38(4):742-52.

(IF 3.038)

250. He CL, Yi PF, Fan QJ, Shen HQ, Jiang XL, Qin QQ, Song Z, Zhang C, Wu SC, Wei XB, Li YL, Fu BD.

.

Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-κB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells.

IMMUNOPHARM IMMUNOT.

2013 Apr;35(2):215-24.

(IF 2.352)

251. Tang Z, Wu M, Li Y, Zheng X, Liu H, Cheng X, Xu L, Wang G, Hao H.

.

Absolute quantification of NAD(P)H:quinone oxidoreductase 1 in human tumor cell lines and tissues by liquid chromatography-mass spectrometry/mass spectrometry using both isotopic and non-isotopic internal standards.

Anal Chim Acta.

2013 Apr 15;772:59-67.

(IF 5.977)

252. Huo K, Zhang X, Wang H, Zhao L, Liu X, Chu PK.

.

Osteogenic activity and antibacterial effects on titanium surfaces modified with Zn-incorporated nanotube arrays.

Biomaterials.

2013 Apr;34(13):3467-78.

(IF 10.317)

253. Yan W, Zhang H, Liu P, Wang H, Liu J, Gao C, Liu Y, Lian K, Yang L, Sun L, Guo Y, Zhang L, Dong L, Lau WB, Gao E, Gao F, Xiong L, Wang H, Qu Y, Tao L.

.

Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing toincreased vulnerability in diabetic heart.

Basic Res Cardiol.

2013 May;108(3):329.

(IF 11.981)

254. Yu SY, Zhang M, Luo J, Zhang L, Shao Y, Li G.

.

Curcumin ameliorates memory deficits via neuronal nitric oxide synthase in aged mice.

PROG NEURO-PSYCHOPH.

2013 May 8;45C:47-53.

(IF 4.361)

255. Wang J, Zeng L, Zhou Q, Xu Y, Pu S, Jiang W, Zhang X, Du D.

.

L6 spinal nerve ligation produces prolonged development of mechanical allodynia and gradual increase of GFAPon ipsilateral dorsal horn.

ACTA NEUROCHIR.

2013 May;155(5):935-40.

(IF 1.817)

256. Jing J, Liu H, Chen H, Hu S, Xiao K, Ma X.

.

Acute effect of copper and cadmium exposure on the expression of heat shock protein 70 in the Cyprinidae fishTanichthys albonubes.

Chemosphere.

2013 May;91(8):1113-22.

(IF 5.778)

257. Wei Q, Shi F.

.

Cleavage of poly (ADP-ribose) polymerase-1 is involved in the process of porcine ovarian follicular atresia.

Anim Reprod Sci.

2013 May;138(3-4):282-91.

(IF 1.66)

258. Bi LQ, Zhu R, Kong H, Wu SL, Li N, Zuo XR, Zhou SM, Kou JP, Yu BY, Wang H, Xie WP.

.

Ruscogenin attenuates monocrotaline-induced pulmonary hypertension in rats.

Int Immunopharmacol.

2013 May;16(1):7-16.

(IF 3.943)

259. Yan M, Shi Y, Wang Y, Wang C, Zhou J, Quan C, Liu C, Yang K.

.

Effects of p,p'-DDE on the mRNA and protein expressions of vimentin, N-cadherin and FSHR in rats testes: an invivo and in vitro study.

ENVIRON TOXICOL CHEM.

2013 May;35(3):486-94.

(IF 3.152)

260. Yi PF, Bi WY, Shen HQ, Wei Q, Zhang LY, Dong HB, Bai HL, Zhang C, Song Z, Qin QQ, Lv S, Wu SC, Fu BD, Wei XB.

.

Inhibitory effects of sulfated 20(S)-ginsenoside Rh2 on the release of pro-inflammatory mediators in LPS-inducedRAW 264.7 cells.

Eur J Pharmacol.

2013 May 9;712(1-3):60-66.

(IF 3.263)

261. Han HY, Zhu SH, Jiang LL, Li Y, Dong H, Zhao QP, Kong CL, Huang B.

.

Molecular characterization and analysis of a novel calcium-dependent protein kinase from Eimeria tenella.

Parasitology.

2013 May;140(6):746-55.

(IF 2.783)

262. Xie N, Wang C, Lian Y, Zhang H, Wu C, Zhang Q.

.

A selective inhibitor of Drp1, mdivi-1, protects against cell death of hippocampal neurons in pilocarpine-inducedseizures in rats.

Neurosci Lett.

2013 Jun 17;545:64-8.

(IF 2.274)

263. Yue Y, Yang X, Wei X, Chen J, Fu N, Fu Y, Ba K, Li G, Yao Y, Liang C, Zhang J, Cai X, Wang M.

.

Osteogenic differentiation of adipose-derived stem cells prompted by low-intensity pulsed ultrasound.

CELL PROLIFERAT.

2013 Jun;46(3):320-7.

(IF 5.753)

264. Chen N, Wu Q, Chi G, Soromou LW, Hou J, Deng Y, Feng H.

.

Prime-O-glucosylcimifugin attenuates lipopolysaccharide-induced acute lung injury in mice.

Int Immunopharmacol.

2013 Jun;16(2):139-47.

(IF 3.943)

265. Tang L, Ma X, Tian Q, Cheng Y, Yao H, Liu Z, Qu X, Han X.

.

Inhibition of angiogenesis and invasion by DMBT is mediated by downregulation of VEGF and MMP-9 through Aktpathway in MDA-MB-231 breast cancer cells.

Food Chem Toxicol.

2013 Jun;56:204-13.

(IF 4.679)

266. Hong JP, Li XM, Li MX, Zheng FL.

.

VEGF suppresses epithelial-mesenchymal transition by inhibiting the expression of Smad3 and miR-192, aSmad3-dependent microRNA.

Int J Mol Med.

2013 Jun;31(6):1436-42.

(IF 3.098)

267. Yan Y, Liu H, Wen H, Jiang X, Cao X, Zhang G, Liu G.

.

The novel estrogen receptor GPER regulates the migration and invasion of ovarian cancer cells.

Mol Cell Biochem.

2013 Jun;378(1-2):1-7.

(IF 2.795)

268. Zou M, Xia S, Zhuang L, Han N, Chu Q, Chao T, Peng P, Chen Y, Gui Q, Yu S.

.

Knockdown of the Bcl-2 gene increases sensitivity to EGFR tyrosine kinase inhibitors in the H1975 lung cancercell line harboring T790M mutation.

Int J Oncol.

2013 Jun;42(6):2094-102.

(IF 3.899)

269. Xue H, Zhang XY, Liu JM, Song Y, Liu TT, Chen D.

.

NDGA reduces secondary damage after spinal cord injury in rats via anti-inflammatory effects.

Brain Res.

2013 Jun 21;1516:83-92.

(IF 2.733)

270. Li L, Ye XP, Lu AZ, Zhou SQ, Liu H, Liu ZJ, Jiang S, Xu SY.

.

Hyperglycemia magnifies bupivacaine-induced cell apoptosis triggered by mitochondria dysfunction andendoplasmic reticulum stress.

J Neurosci Res.

2013 Jun;91(6):786-98.

(IF 4.699)

271. Zhang E, Yan X, Zhang M, Chang X, Bai Z, He Y, Yuan Z.

.

Aggrecanases in the human synovial fluid at different stages of osteoarthritis.

Clin Rheumatol.

2013 Jun;32(6):797-803.

(IF 2.394)

272. Sun L, Zhao M, Yu XJ, Wang H, He X, Liu JK, Zang WJ.

.

Cardioprotection by acetylcholine: a novel mechanism via mitochondrial biogenesis and function involving the PGC-1α pathway.

J Cell Physiol.

2013 Jun;228(6):1238-48.

(IF 5.546)

273. Li X, Wang X, Han C, Wang X, Xing G, Zhou L, Li G, Niu Y.

.

Astragaloside IV suppresses collagen production of activated hepatic stellate cells via oxidative stress-mediatedp38 MAPK pathway.

FREE RADICAL BIO MED.

2013 Jul;60:168-76.

(IF 6.17)

274. Zhang JX, Yang JR, Chen GX, Tang LJ, Li WX, Yang H, Kong X.

.

Sesamin ameliorates arterial dysfunction in spontaneously hypertensive rats via downregulation of NADPHoxidase subunits and upregulation of eNOS expression.

Acta Pharmacol Sin.

2013 Jul;34(7):912-20.

(IF 5.064)

275. Tang Y, Wang YL, Yang L, Xu JX, Xiong W, Xiao M, Li M.

.

Inhibition of arginine ADP-ribosyltransferase 1 reduces the expression of poly(ADP-ribose) polymerase-1 in coloncarcinoma.

Int J Mol Med.

2013 Jul;32(1):130-6.

(IF 3.098)

276. Qing Y, Liang Y, Du Q, Fan P, Xu H, Xu Y, Shi N.

.

Apoptosis induced by Trimethyltin chloride in human neuroblastoma cells SY5Y is regulated by a balance and cross-talk between NF-κB and MAPKs signaling pathways.

Arch Toxicol.

2013 Jul;87(7):1273-85.

(IF 5.059)

277. Zhou D, Wei A, Cao C, Ruan J.

.

DICO, a novel nonaromatic B-ring flavonoid, induces G2/M cell cycle arrest and apoptosis in human hepatomacells.

Food Chem Toxicol.

2013 Jul;57:322-9.

(IF 4.679)

278. Qin D, Li K, Qu J, Wang S, Zou C, Sheng Y, Huang A, Tang H.

.

HBx and HBs regulate RhoC expression by upregulating transcription factor Ets-1.

Arch Virol.

2013 Aug;158(8):1773-81.

(IF 2.243)

279. Chen S, Lin G, Lei L, You X, Wu C, Xu W, Huang M, Luo L, Wang Z, Li Y, Zhao X, Yan F.

.

Hyperlipidemia Modifies Innate Immune Responses to Lipopolysaccharide via the TLR-NF-κB Signaling Pathway.

Inflammation.

2013 Aug;36(4):968-76.

(IF 3.212)

280. Qiu X, Cao L, Yang X, Zhao X, Liu X, Han Y, Xue Y, Jiang H, Chi Z.

.

Role of mitochondrial fission in neuronal injury in pilocarpine-induced epileptic rats.

Neuroscience.

2013 Aug 15;245:157-65.

(IF 3.056)

281. Liu YW, Zhu X, Yang QQ, Lu Q, Wang JY, Li HP, Wei YQ, Yin JL, Yin XX.

.

Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline inrats.

PSYCHOPHARMACOLOGY.

2013 Aug;228(4):585-94.

(IF 3.13)

282. Yan T, Liu Y, Cui K, Hu B, Wang F, Zou L.

.

MiR-126 regulates EPCs function: implications for a role of miR-126 in preeclampsia.

J Cell Biochem.

2013 Sep;114(9):2148-59.

(IF 4.237)

283. Xu T, Wang X, Chen G, He Y, Bie P.

.

Autologous bone marrow stem cell transplantation attenuates hepatocyte apoptosis in a rat model of ex vivo liver resection and liver autotransplantation.

Journal of Surgical Research.

2013 Oct;184(2):1102-8.

(IF 1.872)

284. Li LL, Wang H.

.

Enzyme-Coated Mesoporous Silica Nanoparticles as Efficient Antibacterial Agents In Vivo.

Adv Healthc Mater.

2013 Oct;2(10):1351-60.

(IF 7.367)

285. Zheng XF, Li B, Zhang YH, Yang YH, Meng XY, Jiang SD, Jiang LS.

.

Blockade of substance P receptor attenuates osteoporotic pain, but not bone loss, in ovariectomized mice.

Menopause.

2013 Oct;20(10):1074-83.

(IF 3.305)

286. Jin M, Zhang L, Yu H, Meng J, Sun Z, Lu R.

.

Protective effect of whey protein hydrolysates on H2O2-induced PC12 cells oxidative stress via a mitochondria-mediated pathway.

Food Chemistry.

2013 Nov 15;141(2):847–852.

(IF 5.399)

287. Wang Q, Luo C, Wu X, Du H, Song X, Fan Y.

.

HepaCAM and p-mTOR are closely correlated in transitional cell carcinoma of bladder and expression of hepaCAM inhibits proliferation via an AMPK/mTOR-dependent pathway in human bladder cancer cells.

INT BRAZ J UROL.

2013 Nov;190(5):1812-8..

(IF 1.342)

288. Tang W, Yuan Y, Liu C, Wu Y, Lu X, Qian J.

.

Differential cytotoxicity and particle action of hydroxyapatite nanoparticles in human cancer cells.

NANOMEDICINE-UK.

2014 Mar;9(3):397-412.

(IF 4.3)

289. He Y, He W, Qin G, Luo J, Xiao M.

.

Transplantation KCNMA1 modified bone marrow-mesenchymal stem cell therapy for diabetes mellitus-inducederectile dysfunction.

Andrologia.

2014 Jun;46(5):479-86.

(IF 1.951)

290. Yuan J, Zhang Z, Li L, Song W.

.

Resveratrol affects the expression of glutamate cysteine ligase in the kidneys of aged rats.

Exp Ther Med.

2014 Jun;7(6):1762-1766.

(IF 1.785)

291. Xu H, Wang J, Chang Y, Xu J, Wang Y, Long T, Xue C.

.

Fucoidan from the sea cucumber Acaudina molpadioides exhibits anti-adipogenic activity by modulating the Wnt/β-catenin pathway and down-regulating the SREBP-1c expression.

Food Funct.

2014 Jul 25;5(7):1547-55.

(IF 4.171)

292. Niu LN, Sun JQ, Li QH, Jiao K, Shen LJ, Wu D, Tay F, Chen JH.

.

Intrafibrillar-silicified collagen scaffolds enhance the osteogenic capacity of human dental pulp stem cells.

J Dent.

2014 Jul;42(7):839-49.

(IF 3.242)

293. Li M, Zhang Z, Yuan J, Zhang Y, Jin X.

.

Altered glutamate cysteine ligase expression and activity in renal cell carcinoma.

Biomed Rep..

2014 Nov;2(6):831-834.

294. Ni Q, Wan FQ, Jing YH, Dong XY, Zhang YC.

.

Effect of Acute and Chronic Exposure to High Altitude on the Aerobic and Anaerobic Metabolism in Rats.

ANAL CELL PATHOL.

2015;2015:159549.

(IF 2.052)

295. Zhu Q, Guo R, Liu C, Fu D, Liu F, Hu J, Jiang H.

.

Endoplasmic Reticulum Stress-Mediated Apoptosis Contributing to High Glucose-Induced Vascular SmoothMuscle Cell Calcification.

J Vasc Res.

2015;52(5):291-8.

(IF 1.725)

296. Yu C, Zhou Z, Wang J, Sun J, Liu W, Sun Y, Kong B, Yang H, Yang S.

.

In depth analysis of apoptosis induced by silica coated manganese oxide nanoparticles in vitro.

J Hazard Mater.

2015;283:519-28.

(IF 9.038)

297. Ruan J, Lou S, Dai Q, Mao D, Ji J, Sun X.

.

Tumor suppressor miR-181c attenuates proliferation, invasion, and self-renewal abilities in glioblastoma.

Neuroreport.

2015 Jan 21;26(2):66-73.

(IF 1.394)

298. Li L, Wang L, Shangguan D, Wei Y, Han J, Xiong S, Zhao Z.

.

Ultra-high-performance liquid chromatography electrospray ionization tandem mass spectrometry for accurate analysis of glycerophospholipids and sphingolipids in drug resistance tumor cells.

J Chromatogr A.

2015 Feb 13;1381:140-8.

(IF 4.049)

299. Lv QY, Wan B, Guo LH, Zhao L, Yang Y.

.

In vitro immune toxicity of polybrominated diphenyl ethers on murine peritoneal macrophages: apoptosis and immune cell dysfunction.

Chemosphere.

2015 Feb;120:621-30.

(IF 5.778)

300. Zhang B, Peng X, Li G, Xu Y, Xia X, Wang Q.

.

Oxidative stress is involved in Patulin induced apoptosis in HEK293 cells.

Toxicon.

2015 Feb;94:1-7.

(IF 2.201)

301. Du Z, Yang Q, Liu L, Li S, Zhao J, Hu J, Liu C, Qian D, Gao C.

.

NADPH oxidase 2-dependent oxidative stress, mitochondrial damage and apoptosis in the ventral cochlear nucleus of D-galactose-induced aging rats.

Neuroscience.

2015 Feb 12;286:281-92.

(IF 3.056)

302. Wei H, Wang S, Zhen L, Yang Q, Wu Z, Lei X, Lv J, Xiong L, Xue R.

.

Resveratrol attenuates the blood-brain barrier dysfunction by regulation of the MMP-9/TIMP-1 balance after cerebral ischemia reperfusion in rats.

J Mol Neurosci.

2015 Apr;55(4):872-9.

(IF 2.678)

303. Hu Z, Gu Z, Sun M, Zhang K, Gao P, Yang Q, Yuan Y.

.

Ursolic acid improves survival and attenuates lung injury in septic rats induced by cecal ligation and puncture.

J Surg Res.

2015 Apr;194(2):528-36.

(IF 1.841)

304. Liang M, Jin S, Wu DD, Wang MJ, Zhu YC.

.

Hydrogen sulfide improves glucose metabolism and prevents hypertrophy in cardiomyocytes.

NITRIC OXIDE-BIOL CH.

2015 Apr 30;46:114-22.

(IF 3.311)

305. Cao Q, Jiang Y, Shi J, Xu C, Liu X, Yang T, Fu P, Niu T.

.

Artemisinin inhibits the proliferation, migration, and inflammatory reaction induced by tumor necrosis factor-α in vascular smooth muscle cells through nuclear factor kappa B pathway.

J Surg Res.

2015 Apr;194(2):667-78.

(IF 1.841)

306. Hu H, Gao L, Wang C, Li Y, Ma H, Chen L, Qin J, Liu B, Liu Y, Liang C.

.

Lower serum soluble-EGFR is a potential biomarker for metastasis of HCC demonstrated by N-glycoproteomic analysis.

Discov Med.

2015 May;19(106):333-41.

(IF 2.174)

307. Li H, Jia Z, Li G, Zhao X, Sun P, Wang J, Fan Z, Lv G.

.

Neuroprotective effects of exendin-4 in rat model of spinal cord injury via inhibiting mitochondrial apoptotic pathway.

INT J CLIN EXP PATHO.

2015 May 1;8(5):4837-43.

(IF 0.252)

308. Zhang F, Yang F, Zhao H, An Y.

.

Curcumin alleviates lung injury in diabetic rats by inhibiting NF-κB pathway.

CLIN EXP PHARMACOL P .

2015 Jun 26.doi:10.1111/1440-1681.12438.[Epub ahead of print]

(IF 2.092)

309. Wang J, Chen L, Li H, Yang J, Gong Z, Wang B, Zhao X.

.

Clopidogrel reduces apoptosis and promotes proliferation of human vascular endothelial cells induced by palmitic acid via suppression of the long non-coding RNA HIF1A-AS1 in vitro.

Mol Cell Biochem.

2015 Jun;404(1-2):203-10.

(IF 2.795)

310. Cao W, Li M, Li J, Li C, Xu X, Gu W.

.

Geranylgeranylacetone ameliorates lung ischemia/reperfusion injury by HSP70 and thioredoxin redox system: NF-kB pathway involved.

Pulm Pharmacol Ther.

2015 Jun;32:109-15.

(IF 2.681)

311. Hu Y, Lin X, Wang P, Xue YX, Li Z, Liu LB, Yu B, Feng TD, Liu YH.

.

CRM197 in combination with shRNA interference of VCAM-1 displays enhanced inhibitory effects on human glioblastoma cells.

J Cell Physiol.

2015 Aug;230(8):1713-28.

(IF 5.546)

312. Tian Y, Guo S, Guo Y, Jian L.

.

Anesthetic Propofol Attenuates Apoptosis, Aβ Accumulation, and Inflammation Induced by Sevoflurane Through NF-κB Pathway in Human Neuroglioma Cells.

Cell Mol Neurobiol.

2015 Aug;35(6):891-8.

(IF 3.606)

313. Shen W, Wang L, Pi R, Li Z, Rikang Wang.

.

L-F001, a multifunctional ROCK inhibitor prevents paraquat-induced cell death through attenuating ER stress and mitochondrial dysfunction in PC12 cells.

BIOCHEM BIOPH RES CO.

2015 Aug 28;464(3):794-9.

(IF 2.985)

314. Wang Y, Wang B, Du F, Su X, Sun G, Zhou G, Bian X, Liu N.

.

Epigallocatechin-3-Gallate Attenuates Oxidative Stress and Inflammation in Obstructive Nephropathy via NF-κB and Nrf2/HO-1 Signalling Pathway Regulation.

BASIC CLIN PHARMACOL.

2015 Sep;117(3):164-72.

(IF 2.651)

315. Wang Y, Jiang Y, Ma N, Sang B, Hu X, Cong X, Liu Z.

.

Overexpression of Hiwi Inhibits the Growth and Migration of Chronic Myeloid Leukemia Cells.

Cell Biochem Biophys.

2015 Sep;73(1):117-24.

(IF 2.073)

316. Cheng Y, Yang X, Deng X, Zhang X, Li P, Tao J, Lu Q.

.

MicroRNA-218 inhibits bladder cancer cell proliferation, migration, and invasion by targeting BMI-1.

TUMOR BIOL .

2015 Sep;36(10):8015-23.

(IF 3.65)

317. Wu J, Li H, Sun X, Zhang H, Hao S, Ji M, Yang J, Li K.

.

A Mitochondrion-Targeted Antioxidant Ameliorates Isoflurane-Induced Cognitive Deficits in Aging Mice.

PLoS One.

2015 Sep 17;10(9):e0138256.

(IF 2.74)

318. Guo S, Feng Z.

.

Galectin-3 mediates the effect of PDGF on pulmonary arterial hypertension.

Int J Clin Exp Med.

2015 Sep 15;8(9):15302-7.

(IF 0.166)

319. Wang D, Shi J, Lv S, Xu W, Li J, Ge W, Xiao C, Geng D, Liu Y.

.

Artesunate Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Suppressing TLR, MyD88 Expression, and NF-κB Activation in Microglial Cells.

Inflammation.

2015 Oct;38(5):1925-32.

(IF 3.212)

320. Ma K, Wu HY, Zhang B, He X, Li BX.

.

Neurotoxicity effects of atrazine-induced SH-SY5Y human dopaminergic neuroblastoma cells via microglial activation.

Mol Biosyst.

2015 Oct 13;11(11):2915-24.

(IF 3.336)

321. Zhu D, Wang H, Zhang J, Zhang X, Xin C, Zhang F, Lee Y, Zhang L, Lian K, Yan W, Ma X, Liu Y, Tao L5.

.

Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses.

J Mol Cell Cardiol.

2015 Oct;87:138-47.

(IF 4.133)

322. Chen O, Ye Z, Cao Z, Manaenko A, Ning K, Zhai X, Zhang R, Zhang T, Chen X, Liu W, Sun X.

.

Methane attenuates myocardial ischemia injury in rats through anti-oxidative, anti-apoptotic and anti-inflammatory actions.

FREE RADICAL BIO MED.

2015 Nov 14;90:1-11.

(IF 6.17)

323. Ailijiang N, Chang J, Liang P, Li P, Wu Q, Zhang X, Huang X.

.

Electrical stimulation on biodegradation of phenol and responses of microbial communities in conductive carriers supported biofilms of the bioelectrochemical reactor.

BIORESOURCE TECHNOL.

2015 Nov 17;201:1-7.

(IF 7.539)

324. Wang G, Kang N, Gong H, Luo Y, Bai C, Chen Y, Ji X, Huang C, Dong Q.

.

Upregulation of uncoupling protein Ucp2 through acute cold exposure increases post-thaw sperm quality in zebrafish.

Cryobiology.

2015 Dec;71(3):464-71.

(IF 2.283)

325. Chen L, Mao F, Kirumba GC, Jiang C, Manefield M, He Y.

.

Changes in metabolites, antioxidant system, and gene expression in Microcystis aeruginosa under sodium chloride stress.

ECOTOX ENVIRON SAFE.

2015 Dec;122:126-35.

(IF 4.872)

326. Chen G, Tan ML, Li KK, Leung PC, Ko CH.

.

Green tea polyphenols decreases uric acid level through xanthine oxidase and renal urate transporters in hyperuricemic mice.

J Ethnopharmacol.

2015 Dec 4;175:14-20.

(IF 3.69)

327. You J, Wang Z, Xu S, Zhang W, Fang Q, Liu H, Peng L, Deng T, Lou J .

.

Advanced Glycation End Products Impair Glucose-Stimulated Insulin Secretion of a Pancreatic β-Cell Line INS-1-3 by Disturbance of Microtubule Cytoskeleton via p38/MAPK Activation.

J Diabetes Res.

2016;2016:9073037.

(IF 2.965)

328. Chen Y, Huang W, Jiang W, Wu X, Ye B, Zhou X .

.

HIV-1 Tat Regulates Occludin and Aβ Transfer Receptor Expression in Brain Endothelial Cells

Oxid Med Cell Longev.

2016;2016:4196572.

(IF 5.076)

329. Wang L, He Y, Zhang Y, Zhou H, Yu L, Yang J, Wan H.

.

Effects of Active Components of Fuzi and Gancao Compatibility on Bax, Bcl-2, and Caspase-3 in

EVID-BASED COMPL ALT.

2016;2016:7686045.

(IF 1.813)

330. Guo YJ, Liu JX, Guan YW.

.

Hypoxia induced upregulation of miR-301a/b contributes to increased cell autophagy and viability ofprostate cancer cells by targeting NDRG2.

EUR REV MED PHARMACO.

2016;20(1):101-8.

(IF 3.024)

331. Li R, Wang Y, Zhao E, Wu K, Li W, Shi L, Wang D, Xie G, Yin Y, Deng M, Zhang P, Tao K .

.

Maresin 1, a Proresolving Lipid Mediator, Mitigates Carbon Tetrachloride-Induced

Oxid Med Cell Longev.

2016;2016:9203716.

(IF 5.076)

332. Tongqiang L, Shaopeng L, Xiaofang Y, Nana S, Xialian X, Jiachang H, Ting Z, Xiaoqiang D .

.

Salvianolic Acid B Prevents Iodinated Contrast Media-Induced Acute Renal Injury in Rats via thePI3K/Akt/Nrf2 Pathway.

Oxid Med Cell Longev.

2016;2016:7079487.

(IF 5.076)

333. Bai J, Zheng Y, Wang G, Liu P.

.

Protective Effect of D-Limonene against Oxidative Stress-Induced Cell Damage in Human Lens Epithelial Cells via the p38 Pathway.

Oxid Med Cell Longev.

2016;2016:5962832.

(IF 5.076)

334. Wan L, Zhang L, Fan K, Cheng ZX, Sun QC, Wang JJ.

.

Knockdown of Long Noncoding RNA PCAT6 Inhibits Proliferation and Invasion in Lung Cancer Cells.

Oncol Res.

2016;24(3):161-70.

(IF 4.949)

335. Yu W, Zha W, Ke Z, Min Q, Li C, Sun H, Liu C .

.

Curcumin Protects Neonatal Rat Cardiomyocytes against High Glucose-Induced Apoptosis via PI3K/AktSignalling Pathway.

J Diabetes Res.

2016;2016:4158591.

(IF 2.965)

336. He P, Zhang HX, Sun CY, Chen CY, Jiang HQ.

.

Overexpression of SASH1 Inhibits the Proliferation, Invasion,and EMT in Hepatocarcinoma Cell.

Oncol Res.

2016;24(1):25-32.

(IF 4.949)

337. Li R, Wang Y, Ma Z, Ma M, Wang D, Xie G, Yin Y, Zhang P, Tao K .

.

Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis.

MEDIAT INFLAMM.

2016;2016:3798465.

(IF 3.758)

338. Fu HL, Shao L.

.

Silencing of NUF2 inhibits proliferation of human osteosarcoma Saos-2 cells.

EUR REV MED PHARMACO.

2016;20(6):1071-9.

(IF 3.024)

339. Li L, Liu HC, Wang C, Liu X, Hu FC, Xie N, Lü L, Chen X, Huang HZ.

.

Overexpression of β-Catenin Induces Cisplatin Resistance in Oral Squamous Cell Carcinoma.

Biomed Res Int.

2016;2016:5378567.

(IF 2.276)

340. Hu J, Liu G, Zhao Z, Jia W, Xia H.

.

MicroRNA-197 Mediates the Overgrowth and Anti-Apoptotic Effects by Downregulating Insulin-Like GrowthFactor-Binding Protein-3 During Nephroblastoma Tumorigenesis.

Fetal Pediatr Pathol.

2016;35(5):287-298.

(IF 0.596)

341. Li LS, Luo YM, Liu J, Zhang Y, Fu XX, Yang DL .

.

Icariin Inhibits Pulmonary Hypertension Induced by Monocrotaline through Enhancement of NO/cGMPSignaling Pathway in Rats.

EVID-BASED COMPL ALT.

2016;2016:7915415.

(IF 1.813)

342. Zhang C, Li L, Zhao B, Jiao A, Li X, Sun N, Zhang J .

.

Ghrelin Protects against Dexamethasone-Induced INS-1 Cell Apoptosis via ERK and p38MAPK Signaling.

Int J Endocrinol.

2016;2016:4513051.

(IF 2.299)

343. Du W, Liang H, Gao X, Li X, Zhang Y, Pan Z, Li C, Wang Y, Liu Y, Yuan W, Ma N, Chu W, Shan H, Lu Y.

.

MicroRNA-328, a Potential Anti-Fibrotic Target in Cardiac Interstitial Fibrosis.

CELL PHYSIOL BIOCHEM.

2016;39(3):827-36.

(IF 5.5)

344. Fan K, Li H, Wang Z, Du W, Yin W, Sun Y, Jiang J .

.

Expression and purification of the recombinant porcine NK-lysin in Pichia

Prep Biochem Biotechnol.

2016;46(1):65-70.

345. Wang L, Yue Z, Guo M, Fang L, Bai L, Li X, Tao Y, Wang S, Liu Q, Zhi D, Zhao H.

.

Dietary Flavonoid Hyperoside Induces Apoptosis of Activated Human LX-2 Hepatic Stellate Cell bySuppressing Canonical NF-κB Signaling.

Biomed Res Int.

2016;2016:1068528.

(IF 2.276)

346. Peng Y, Lai M, Lou Y, Liu Y, Wang H, Zheng X.

.

Efficient induction of cross-presentating human B cell by transduction with human adenovirus type 7vector.

Immunol Lett.

2016 Jan;169:41-51.

(IF 3.276)

347. Tan G, Liu D, Pan F, Zhao J, Li T, Ma Y, Shen B, Lyu J .

.

His-87 ligand in mitoNEET is crucial for the transfer of iron sulfur clusters from

BIOCHEM BIOPH RES CO.

2016 Jan 29;470(1):226-32.

(IF 2.985)

348. Ge Q, Wang C, Ruan Y, Chen Z, Liu J, Ye Z .

.

Overexpression of p53 activated by small activating RNA suppresses the growth of human prostate cancercells.

ONCOTARGETS THER.

2016 Jan 8;9:231-41.

(IF 3.337)

349. Li L, Wu R, Yan G, Gao M, Deng C, Zhang X .

.

A novel method to isolate protein N-terminal peptides from proteome samples using sulfydryl tagging andgold-nanoparticle-based depletion.

Anal Bioanal Chem.

2016

Jan;408(2):441-8.

(IF 3.637)

350. Hu Q, Chen J, Zhang J, Xu C, Yang S, Jiang H .

.

IOX1,a JMJD2A inhibitor, suppresses the proliferation and migration of vascular smooth muscle cellsinduced by angiotensin II by regulating the expression of cell cycle-related proteins.

Int J Mol Med.

2016 Jan;37(1):189-96.

(IF 3.098)

351. Zou Q, Hong W, Zhou Y, Ding Q, Wang J, Jin W, Gao J, Hua G, Xu X .

.

Bone marrow stem cell dysfunction in radiation-induced abscopal bone loss.

J Orthop Surg Res.

2016 Jan 7;11:3.

(IF 1.777)

352. Zhao Y, Liu X, He Z, Niu X, Shi W, Ding JM, Zhang L, Yuan T, Li A, Yang W, Lu L .

.

Essential role of proteasomes in maintaining self-renewal in neural progenitor cells.

SCI REP-UK.

2016 Jan 25;6:19752.

(IF 3.998)

353. Yang H, Yin P, Shi Z, Ma Y, Zhao C, Zheng J, Chen T .

.

Sinomenine, a COX-2 inhibitor, induces cell cycle arrest and inhibits growth of human

Oncol Lett.

2016 Jan;11(1):411-418.

(IF 2.311)

354. Zhang DQ, Sun P, Jin Q, Li X, Zhang Y, Zhang YJ, Wu YL, Nan JX, Lian LH .

.

Resveratrol Regulates Activated Hepatic Stellate Cells by Modulating NF-κB and the PI3K/Akt

J Food Sci.

2016 Jan;81(1):H240-5.

(IF 2.478)

355. Gao X, Wu X, Zhang X, Hua W, Zhang Y, Maimaiti Y, Gao Z, Zhang Y .

.

Inhibition of BRD4 suppresses tumor growth and enhances iodine uptake in thyroid cancer.

BIOCHEM BIOPH RES CO.

2016 Jan 15;469(3):679-85.

(IF 2.985)

356. Hu H, Xuan Y, Xue M, Cheng W, Wang Y, Li X, Yin J, Li X, Yang N, Shi Y, Yan S.

.

Semaphorin 3A attenuates cardiac autonomic disorders and reduces inducible ventricular arrhythmias inrats with experimental myocardial infarction.

BMC CARDIOVASC DISOR.

2016 Jan 19;16:16.

(IF 2.078)

357. Tang Y, Cui Y, Li Z, Jiao Z, Zhang Y, He Y, Chen G, Zhou Q, Wang W, Zhou X, Luo J, Zhang S.

.

Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 inhuman lung cancer cells.

J EXP CLIN CANC RES.

2016 Jan 12;35:7.

(IF 7.068)

358. Peng X, Zhang YY, Wang J, Ji Q.

.

Ethylacetate extract from Tetrastigma hemsleyanum induces apoptosis via the mitochondrial caspase-dependent intrinsic pathway in HepG2 cells.

TUMOR BIOL .

2016 Jan;37(1):865-76.

(IF 3.65)

359. Li L, Wu R, Yan G, Gao M, Deng C, Zhang X.

.

A novel method to isolate protein N-terminal peptides from proteome samples using sulfydryl tagging and gold-nanoparticle-based depletion.

Anal Bioanal Chem.

2016 Jan;408(2):441-8.

(IF 3.637)

360. Pei G, Liu G, Pan X, Pang Y, Li Q.

.

L-C1qDC-, a novel C1q domain-containing protein from Lethenteron camtschaticum that is involved in the immune response.

Dev Comp Immunol.

2016 Jan;54(1):66-74.

(IF 3.192)

361. Xue Z, Zhou Y, Wang C, Zheng J, Zhang P, Zhou L, Wu L, Shan Y, Ye M, He Y, Cai Z.

.

Latexin exhibits tumor-suppressor potential in pancreatic ductal adenocarcinoma.

Oncol Rep.

2016 Jan;35(1):50-8.

(IF 3.417)

362. Pei G, Liu G, Pan X, Pang Y, Li Q .

.

L-C1qDC-1, a novel C1q domain-containing protein from Lethenteron camtschaticum that is involved in theimmune response.

Dev Comp Immunol.

2016 Jan;54(1):66-74.

(IF 3.192)

363. Jiang W, Luo F, Lu Q, Liu J, Li P, Wang X, Fu Y, Hao K, Yan T, Ding X .

.

The protective effect of Trillin LPS-induced acute lung injury by the regulations of inflammation andoxidative state.

CHEM-BIOL INTERACT.

2016 Jan 5;243:127-34.

(IF 3.723)

364. Jiang Q, Liu Y, Gou M, Han J, Wang J, Li Q, Xiao R .

.

Data for the inhibition effects of recombinant lamprey CRBGP on the tube formation of

Data Brief.

2016 Jan 13;6:661-7.

365. Li L, Du J, Lian Y, Zhang Y, Li X, Liu Y, Zou L, Wu T .

.

Protective Effects of Coenzyme Q10 Against Hydrogen Peroxide-Induced Oxidative Stress in PC12 Cell: TheRole of Nrf2 and Antioxidant Enzymes.

Cell Mol Neurobiol.

2016 Jan;36(1):103-11.

(IF 3.606)

366. Wu Y, Qi Y, Liu H, Wang X, Zhu H, Wang Z.

.

AMPK activator AICAR promotes 5-FU-induced apoptosis in gastric cancer cells.

Mol Cell Biochem.

2016 Jan;411(1-2):299-305.

(IF 2.795)

367. Liu C, Chen Z, Fang J, Xu A, Zhang W, Wang Z .

.

H19-derived miR-675 contributes to bladder cancer cell proliferation by regulating p53 activation.

TUMOR BIOL .

2016 Jan;37(1):263-70.

(IF 3.65)

368. Liu Y, Zhao Y, Guo L.

.

Effects of orexin A on glucose metabolism in human hepatocellular carcinoma in vitro via PI3K/Akt/mTOR-dependent and -independent mechanism.

Mol Cell Endocrinol.

2016 Jan 15;420:208-16.

(IF 3.871)

369. Zhou Q, Yang P, Li X, Liu H, Ge S.

.

Bioactivity of periodontal ligament stem cells on sodium titanate coated with graphene oxide.

SCI REP-UK.

2016 Jan 14;6:19343.

(IF 3.998)

370. Zhao F, Fu L, Yang W, Dong Y, Yang J, Sun S 4, Hou Y .

.

Cardioprotective effects of baicalein on heart failure via modulation of Ca(2+) handling proteins in vivo and in vitro.

Life Sci.

2016 Jan 15;145:213-23.

(IF 3.647)

371. Ha M, Wei L, Guan X, Li L, Liu C.

.

p53-dependent apoptosis contributes to di-(2-ethylhexyl) phthalate-induced hepatotoxicity.

Environ Pollut.

2016 Jan;208(Pt B):416-25.

(IF 6.792)

372. Huang L, Li M, Wang D, He J, Wu W, Zeng Q, Li J, Xiao M, Hu J, He Y, Li Y, Mai L, Liu W.

.

Overexpressed Rce1 is positively correlated with tumor progression and predicts poor prognosis inprostate cancer.

Hum Pathol.

2016 Jan;47(1):109-14.

(IF 2.735)

373. Pei G, Liu G, Pan X, Pang Y, Li Q.

.

L-C1qDC-1, a novel C1q domain-containing protein from Lethenteron camtschaticum that is involved in the immune response.

Dev Comp Immunol.

2016 Jan;54(1):66-74.

(IF 3.192)

374. Zhao H, Zheng Q, Hu X, Shen H, Li F .

.

Betulin attenuates kidney injury in septic rats through inhibiting TLR4/NF-κB signaling pathway.

Life Sci.

2016 Jan 1;144:185-93.

(IF 3.647)

375. Zhou N, Qu Y, Xu C, Tang Y .

.

Upregulation of microRNA-375 increases the cisplatin-sensitivity of human gastric cancer cells byregulating ERBB2.

Exp Ther Med.

2016 Feb;11(2):625-630.

(IF 1.785)

376. Wang Y, Sun Q, Guo W, Chen X, Du Y, Zang W, Dong Z, Zhao G.

.

G648C variant of DNA polymerase β sensitizes esophageal cancer to chemotherapy.

TUMOR BIOL .

2016 Feb;37(2):1941-7.

(IF 3.65)

377. Cai X, Bao L, Ren J, Li Y, Zhang Z .

.

Grape seed procyanidin B2 protects podocytes from high glucose-induced mitochondrial dysfunction andapoptosis via the AMPK-SIRT1-PGC-1α axis in vitro.

Food Funct.

2016 Feb;7(2):805-15.

(IF 4.171)

378. Xia P, Chen HY, Chen SF, Wang L, Strappe PM, Yang HL, Zhou CH, Zhang X, Zhang YX, Ma LL, Wang L .

.

The stimulatory effects of eNOS/F92A-Cav1 on NO production and angiogenesis in BMSCs.

Biomed Pharmacother.

2016 Feb;77:7-13.

(IF 4.545)

379. Zhong X, Song X, Wang N, Hu D, Liu T, Wang T, Gu X, Lai W, Peng X, Yang G.

.

Molecular identification and characterization of prohibitin from Echinococcus granulosus.

Parasitol Res.

2016 Feb;115(2):897-902.

(IF 1.641)

380. Gao H, Wang J .

.

Andrographolide inhibits multiple myeloma cells by inhibiting the TLR4/NF-κB signaling

Mol Med Rep.

2016 Feb;13(2):1827-32.

(IF 2.1)

381. Lu W, Huang SY, Su L, Zhao BX, Miao JY.

.

Long Noncoding RNA LOC100129973 Suppresses Apoptosis by Targeting miR-4707-5p and miR-4767 inVascular Endothelial Cells.

SCI REP-UK.

2016 Feb 18;6:21620.

(IF 3.998)

382. Chen Z, Xue J, Shen T, Ba G, Yu D, Fu Q .

.

Curcumin alleviates glucocorticoid-induced osteoporosis by protecting osteoblasts from apoptosis in vivoand in vitro.

CLIN EXP PHARMACOL P .

2016 Feb;43(2):268-76.

(IF 2.092)

383. Wang X, He G, Mai K, Xu W, Zhou H.

.

Differential regulation of taurine biosynthesis in rainbow trout and Japanese flounder.

SCI REP-UK.

2016 Feb 16;6:21231.

(IF 3.998)

384. Chen D, Yan W, Liu Z, Zhang Z, Zhu L, Liu W, Ding X, Wang A, Chen Y .

.

Downregulation of miR-221 enhances the sensitivity of human oral squamous cell carcinoma cells toAdriamycin through upregulation of TIMP3 expression.

Biomed Pharmacother.

2016 Feb;77:72-8.

(IF 4.545)

385. Wu H, Liu J, Li W, Liu G, Li Z.

.

LncRNA-HOTAIR promotes TNF-α production in cardiomyocytes of LPS-induced sepsis mice by activatingNF-κB pathway.

BIOCHEM BIOPH RES CO.

2016 Feb 26;471(1):240-6.

(IF 2.985)

386. Yuan L, Sui T, Chen M, Deng J, Huang Y, Zeng J, Lv Q, Song Y, Li Z, Lai L.

.

CRISPR/Cas9-mediated GJA8 knockout in rabbits recapitulates human congenital cataracts.

SCI REP-UK.

2016 Feb 25;6:22024.

(IF 3.998)

387. Zhang R, Li L, Yuan L, Zhao M.

.

Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase 2 and FAK/AKT pathway.

Exp Mol Pathol.

2016 Feb;100(1):51-8.

(IF 2.28)

388. Huang W, Liu Z, Zhou G, Tian A, Sun N .

.

Magnetic gold nanoparticle-mediated small interference RNA silencing Bag-1 gene for colon cancer therapy.

Oncol Rep.

2016 Feb;35(2):978-84.

(IF 3.417)

389. Zhong J, Li X, Wan L, Chen Z, Zhong S, Xiao S, Yan Z .

.

Knockdown of NogoA prevents MPP+-induced neurotoxicity in PC12 cells via the mTOR/STAT3 signalingpathway.

Mol Med Rep.

2016 Feb;13(2):1427-33.

(IF 2.1)

390. Zhang R, Li L, Yuan L, Zhao M .

.

Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation-induced cell apoptosis viasphingosine kinase 2 and FAK/AKT pathway.

Exp Mol Pathol.

2016 Feb;100(1):51-8.

(IF 2.28)

391. Zhao Y, Tan K, Zhou Y, Ye Z, Tan WS .

.

A combinatorial variation in surface chemistry and pore size of three-dimensional porous poly(ε-caprolactone) scaffolds modulates the behaviors of mesenchymal stem cells.

MAT SCI ENG C-MATER.

2016 Feb;59:193-202.

(IF 5.88)

392. Zhang K, Liu J, You X, Kong P, Song Y, Cao L, Yang S, Wang W7, Fu Q, Ma Z .

.

P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice.

Neurosci Lett.

2016 Feb 2;613:60-5.

(IF 2.274)

393. Xu T, Zong Y, Peng L, Kong S, Zhou M, Zou J, Liu J, Miao R, Sun X, Li L .

.

Overexpression of eIF4E in colorectal cancer patients is associated with liver metastasis.

ONCOTARGETS THER.

2016 Feb 19;9:815-22.

(IF 3.337)

394. Chen Z, Xue J, Shen T, Mu S, Fu Q.

.

Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation of the Wnt

Int J Mol Med.

2016 Feb;37(2):329-38.

(IF 3.098)

395. Li H, Zhang C, Cui H, Guo K, Wang F, Zhao T, Liang W, Lv Q, Zhang Y .

.

FKBP8 interact with classical swine fever virus NS5A protein and promote virus RNA replication.

Virus Genes.

2016 Feb;52(1):99-106.

(IF 1.991)

396. Zhang W, Tong D, Liu F, Li D, Li J, Cheng X, Wang Z .

.

RPS7 inhibits colorectal cancer growth via decreasing HIF-1α-mediated glycolysis.

ONCOTARGET.

2016 Feb 2;7(5):5800-14.

(IF 5.168)

397. Chen L, Guan H, Gu C, Cao Y, Shao J, Wang F .

.

miR-383 inhibits hepatocellular carcinoma cell proliferation via targeting APRIL.

TUMOR BIOL .

2016 Feb;37(2):2497-507.

(IF 3.65)

398. He B, Xiao YF, Tang B, Wu YY, Hu CJ, Xie R, Yang X, Yu ST, Dong H, Zhao XY, Li JL, Yang SM.

.

hTERT mediates gastric cancer metastasis partially throughthe indirect targeting of ITGB1 by microRNA-29a.

SCI REP-UK.

2016 Feb 23;6:21955.

(IF 3.998)

399. Zhang L, Gan X, Zhu Z, Yang Y, He Y, Yu H .

.

Reactive oxygen species regulatory mechanisms associated with rapid response of MC3T3-E1 cells for vibration stress.

BIOCHEM BIOPH RES CO.

2016 Feb 12;470(3):510-5.

(IF 2.985)

400. Wang X, Chen X, Yang X, Gao W, He B, Dai W, Zhang H, Wang X, Wang J, Zhang X, Dai Z, Zhang Q.

.

A nanomedicine based combination therapy based on QLPVM peptide functionalized liposomaltamoxifenand doxorubicin against Luminal A breast cancer.

Nanomedicine.

2016 Feb;12(2):387-97.

(IF 4.717)

401. Fang Y, Su T, Qiu X, Mao P, Xu Y, Hu Z, Zhang Y, Zheng X, Xie P, Liu Q .

.

Protective effect of alpha-mangostin against oxidative stress induced-retinal cell death.

SCI REP-UK.

2016 Feb 18;6:21018.

(IF 3.998)

402. Yu W, Gao XJ, Liu Y, Wang Q.

.

Fusion expression of cecropin B-like antibacterial peptide in Pichia GS115 and its antibacterial

Biotechnol Lett.

2016 Feb;38(2):305-12.

(IF 1.977)

403. Dong YF, Chen ZZ, Zhao Z, Yang DD, Yan H, Ji J, Sun XL.

.

Potential role of microRNA-7 in the anti-neuroinflammation effects of nicorandil in astrocytes induced byoxygen-glucose deprivation.

J NEUROINFLAMM.

2016 Mar 9;13(1):60.

(IF 5.793)

404. Zhang D, Fei Q, Li J, Zhang C, Sun Y, Zhu C, Wang F, Sun Y .

.

2-Deoxyglucose Reverses the Promoting Effect of Insulin on Colorectal Cancer Cells In Vitro.

PLoS One.

2016 Mar 3;11(3):e0151115.

(IF 2.74)

405. Weifeng Y, Li L, Yujie H, Weifeng L, Zhenhui G, Wenjie H .

.

Inhibition of Acute Lung Injury by TNFR-Fc through Regulation of an Inflammation-Oxidative StressPathway.

PLoS One.

2016 Mar 18;11(3):e0151672.

(IF 2.74)

406. Cao Z, Fu Y, Sun X, Zhang Q, Xu F, Li Y .

.

Aluminum trichloride inhibits osteoblastic differentiation through inactivation of Wnt/β-catenin signalingpathway in rat osteoblasts.

ENVIRON TOXICOL CHEM.

2016 Mar;42:198-204.

(IF 3.152)

407. Liu B, Li T, Peng JJ, Zhang JJ, Liu WQ, Luo XJ, Ma QL, Gong ZC, Peng J .

.

Non-muscle myosin light chain promotes endothelial progenitor cells senescence and dysfunction inpulmonary hypertensive rats through up-regulation of NADPH oxidase.

Eur J Pharmacol.

2016 Mar 15;775:67-77.

(IF 3.263)

408. Miao L, Xin X, Xin H, Shen X, Zhu YZ .

.

Hydrogen Sulfide Recruits Macrophage Migration by Integrin β1-Src-FAK/Pyk2-Rac Pathway in MyocardialInfarction.

SCI REP-UK.

2016 Mar 2;6:22363.

(IF 3.998)

409. Wang X, Chen E, Yang X, Wang Y, Quan Z, Wu X, Luo C .

.

5-azacytidine inhibits the proliferation of bladder cancer cells via reversal of the aberrant hypermethylationof the hepaCAM gene.

Oncol Rep.

2016 Mar;35(3):1375-84.

(IF 3.417)

410. Ju H, Yang Y, Sheng A, Qi Y.

.

MicroRNA-378 promotes myogenic differentiation by targeting BMP4.

Mol Med Rep.

2016 Mar;13(3):2194-200.

(IF 2.1)

411. Ren X, Wang L, Wu X .

.

A potential link between TSLP/TSLPR/STAT5 and TLR2/MyD88/NFκB-p65 in human corneal epithelial cellsfor Aspergillus fumigatus tolerance.

Mol Immunol.

2016 Mar;71:98-106.

(IF 3.641)

412. Fu X, Pang X, Qi H, Chen S, Li Y, Tan W.

.

XIAP inhibitor Embelin inhibits bladder cancer survival and invasion in vitro.

Clin Transl Oncol.

2016 Mar;18(3):277-82.

(IF 2.737)

413. Jiao Y, Ma S, Wang Y, Li J, Shan L, Sun J, Chen J .

.

Methacryloxylethyl Cetyl Ammonium Chloride Induces DNA Damage and Apoptosis in Human Dental PulpCells via Generation of Oxidative Stress.

Int J Biol Sci.

2016 Mar 21;12(5):580-93.

(IF 4.858)

414. Cai ZZ, Xu JG, Zhou YH, Zheng JH, Lin KZ, Zheng SZ, Ye MS, He Y, Liu CB, Xue ZX .

.

Human cytomegalovirus-encoded US28 may act as a tumor promoter in colorectal cancer.

WORLD J GASTROENTERO.

2016 Mar 7;22(9):2789-98.

(IF 3.665)

415. Liu HZ, Wang QY, Zhang Y, Qi DT, Li MW, Guo WQ, Ma YH, Wang LY, Chen Y, Gao CY.

.

Pioglitazone up-regulates long non-coding RNA MEG3 to protect endothelial progenitor cells via increasingHDAC7 expression in metabolic syndrome.

Biomed Pharmacother.

2016 Mar;78:101-9.

(IF 4.545)

416. Zhu Y, Zhao H, Feng L, Xu S.

.

MicroRNA-217 inhibits cell proliferation and invasion by targeting Runx2 in human glioma.

Am J Transl Res.

2016 Mar 15;8(3):1482-91.

(IF 3.375)

417. Hu JJ, Song W, Zhang SD, Shen XH, Qiu XM, Wu HZ, Gong PH, Lu S, Zhao ZJ, He ML, Fan H.

.

HBx-upregulated lncRNA UCA1 promotes cell growth and tumorigenesis by recruiting EZH2 andrepressingp27Kip1/CDK2 signaling.

SCI REP-UK.

2016 Mar 24;6:23521.

(IF 3.998)

418. Wang YP, Song GH, Chen J, Xiao C, Li C, Zhong L, Sun X, Wang ZW, Deng GL, Yu FD, Xue YM, Tang HM, Peng ZH, Wang XL.

.

Elevated OCT1 participates in colon tumorigenesis and independently predicts poor prognoses ofcolorectal cancer patients.

TUMOR BIOL .

2016 Mar;37(3):3247-55.

(IF 3.65)

419. Du L, Lv R, Yang X, Cheng S, Ma T, Xu J.

.

Hypoxic conditioned medium of placenta-derived mesenchymal stem cells protects against scar formation.

Life Sci.

2016 Mar 15;149:51-7.

(IF 3.647)

420. Ma Y, Gai Y, Yan J, Li J, Zhang Y.

.

Puerarin Attenuates Anoxia/Reoxygenation Injury Through Enhancing Bcl-2 Associated Athanogene 3Expression, a Modulator of Apoptosis and Autophagy.

MED SCI MONITOR.

2016 Mar 24;22:977-83.

(IF 1.918)

421. Li TB, Zhang JJ, Liu B, Liu WQ, Wu Y, Xiong XM, Luo XJ, Ma QL, Peng J.

.

Involvement of NADPH oxidases and non-muscle myosin light chain in senescence of endothelial progenitorcells in hyperlipidemia.

N-S ARCH PHARMACOL.

2016 Mar;389(3):289-302.

(IF 2.05)

422. Zhou J, Li W, Guo J, Li G, Chen F, Zhou J .

.

Downregulation of miR-329 promotes cell invasion by regulating BRD4 and predicts poor prognosis inhepatocellular carcinoma.

TUMOR BIOL .

2016 Mar;37(3):3561-9.

(IF 3.65)

423. Kong L, Guo S, Liu C, Zhao Y, Feng C, Liu Y, Wang T, Li C .

.

Overexpression of SDF-1 activates the NF-κB pathway to induce epithelial to mesenchymal transition and cancer stem cell-like phenotypes of breast cancer cells.

Int J Oncol.

2016 Mar;48(3):1085-94.

(IF 3.899)

424. Dong Z, Tai W, Lei W, Wang Y, Li Z, Zhang T.

.

IL-27 inhibits the TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells.

BMC Cell Biol.

2016 Mar 1;17:7.

(IF 3.066)

425. Tian Y, Guo R, Shi B, Chen L, Yang L, Fu Q.

.

MicroRNA-30a promotes chondrogenic differentiation of mesenchymal stem cells through inhibiting Delta-like 4 expression.

Life Sci.

2016 Mar 1;148:220-8.

(IF 3.647)

426. Ji K, Xue L, Cheng J, Bai Y.

.

Preconditioning of H2S inhalation protects against cerebral ischemia/reperfusion injury by induction ofHSP70 through PI3K/Akt/Nrf2 pathway.

Brain Res Bull.

2016 Mar;121:68-74.

(IF 3.37)

427. Wu D, Zhang J, Wang J, Li J, Liao F, Dong W .

.

Hesperetin induces apoptosis of esophageal cancer cells via mitochondrial pathway mediated by theincreased intracellular reactive oxygen species.

TUMOR BIOL .

2016 Mar;37(3):3451-9.

(IF 3.65)

428. Chu W, Wei W, Yu S, Han H, Shi X, Sun W, Gao Y, Zhang L, Chen J .

.

C2C12 myotubes inhibit the proliferation and differentiation of 3T3-L1 preadipocytes by reducing theexpression of glucocorticoid receptor gene.

BIOCHEM BIOPH RES CO.

2016 Mar 25;472(1):68-74.

(IF 2.985)

429. KoraMagazi A, Wang D, Yousef B, Guerram M, Yu F .

.

Rhein triggers apoptosis via induction of endoplasmic reticulum stress, caspase-4 and intracellular calciumin primary human hepatic HL-7702 cells.

BIOCHEM BIOPH RES CO.

2016 Apr 22;473(1):230-6.

(IF 2.985)

430. Wang X, Guo H, Liu W, Yang C, Yang L, Wang D, Wang X.

.

Effects of siRNA-Mediated Knockdown of HDAC1 on the Biological Behavior of Esophageal Carcinoma CellLines.

MED SCI MONITOR.

2016 Apr 18;22:1291-6.

(IF 1.918)

431. Wang N, Wei H, Yin D, Lu Y, Zhang Y, Zhang Q, Ma X, Zhang S.

.

MicroRNA-195 inhibits proliferation of cervical cancer cells by targeting cyclin D1a.

TUMOR BIOL .

2016 Apr;37(4):4711-20.

(IF 3.65)

432. Wang X, Liang Z, Hou J, Bao X, Shen Y.

.

Identification and functional evaluation of the reductases and dehydrogenases from

BMC Biotechnol.

2016 Apr 1;16:31.

(IF 2.312)

433. Li J, Qiu D, Chen Z, Du W, Liu J, Mo X .

.

Altered expression of miR-125a-5p in thymoma-associated myasthenia gravis and its down-regulation offoxp3 expression in Jurkat cells.

Immunol Lett.

2016 Apr;172:47-55.

(IF 3.276)

434. Jiang Q, Liu Y, Duan D, Gou M, Wang H, Wang J, Li Q, Xiao R .

.

Anti-angiogenic activities of CRBGP from buccal glands of lampreys (Lampetra japonica).

Biochimie.

2016 Apr;123:7-19.

(IF 3.413)

435. Shang H, Sun J, Chen YQ .

.

Clostridium Butyricum CGMCC0313.1 Modulates Lipid Profile, Insulin Resistance and Colon Homeostasis inObese Mice.

PLoS One.

2016 Apr 28;11(4):e0154373.

(IF 2.74)

436. Zhou Y, Wang Y, Li Y, Nick N, Zou X, Bai F, Wu J, Xin J .

.

P19 contributes to Mycoplasma mycoides subsp. mycoides adhesion to EBL cells.

MICROB PATHOGENESIS.

2016 Apr;93:13-21.

(IF 2.914)

437. Wang X, Xu W, Fan M, Meng T, Chen X, Jiang Y, Zhu D7, Hu W, Gong J, Feng S, Wu J, Li Y .

.

Deoxynivalenol induces apoptosis in PC12 cells via the mitochondrial pathway.

ENVIRON TOXICOL CHEM.

2016 Apr;43:193-202.

(IF 3.152)

438. Zhang S, Li J, Zhou G, Mu D, Yan J, Xing J, Yao Z, Sheng H, Li D, Lv C, Sun B, Hong Q, Guo H .

.

Increased expression of ESCO1 is correlated with poor patient survival and its role in human bladdercancer.

TUMOR BIOL .

2016 Apr;37(4):5165-70.

(IF 3.65)

439. Wu S, Zhang G, Li P, Chen S, Zhang F, Li J, Jiang C, Chen X, Wang Y, Du Y, Sun Q, Zhao G.

.

miR-198 targets SHMT1 to inhibit cell proliferation and enhance cell apoptosis in lung adenocarcinoma.

TUMOR BIOL .

2016 Apr;37(4):5193-202.

(IF 3.65)

440. Gan F, Hu Z, Huang Y, Xue H, Huang D, Qian G, Hu J, Chen X, Wang T, Huang K.

.

Overexpression of pig selenoprotein S blocks OTA-induced promotion of PCV2 replication by inhibiting oxidative stress and p38 phosphorylation in PK15 cells.

ONCOTARGET.

2016 Apr 12;7(15):20469-85.

(IF 5.168)

441. Bi Y, Cao J, Jin S, Lv L, Qi L, Liu F, Geng J, Yu Y .

.

Interleukin-22 promotes lung cancer cell proliferation and migration via the IL-22R1/STAT3 and IL-22R1/AKTsignaling pathways.

Mol Cell Biochem.

2016 Apr;415(1-2):1-11.

(IF 2.795)

442. Wang Y, Zhang B, Liu W, Dai Y, Shi Y, Zeng Q, Wang F .

.

Noninvasive bioluminescence imaging of the dynamics of sanguinarine induced apoptosis via activation ofreactive oxygen species.

ONCOTARGET.

2016 Apr 19;7(16):22355-67.

(IF 5.168)

443. Peng Z, Zhang Y .

.

Propofol inhibits proliferation and accelerates apoptosis of human gastric cancer cells by regulation ofmicroRNA-451 and MMP-2 expression.

GENET MOL RES.

2016 Apr 4;15(2).

(IF 1.013)

444. Zhang Y, Liu C, Wang J, Li Q, Ping H, Gao S, Wang P.

.

MiR-299-5p regulates apoptosis through autophagy in neurons and ameliorates cognitive capacity inAPPswe/PS1dE9 mice.

SCI REP-UK.

2016 Apr 15;6:24566.

(IF 3.998)

445. Jiang K, Zhuang Y, Yan M, Chen H, Ge AQ, Sun L, Miao B.

.

Effects of riluzole on P2X7R expression in the spinal cord in rat model of neuropathic pain.

Neurosci Lett.

2016 Apr 8;618:127-33.

(IF 2.274)

446. Tao W, Wang H, Su Q, Chen Y, Xue W, Xia B, Duan J, Chen G.

.

Paeonol attenuates lipopolysaccharide-induced depressive-like behavior in mice.

Psychiatry Res.

2016 Apr 30;238:116-21.

447. Zhang Y, Lei W, Yan W, Li X, Wang X, Zhao Z, Hui J, Shen Z, Yang J .

.

microRNA-206 is involved in survival of hypoxia preconditioned mesenchymal stem cells through targetingPim-1 kinase.

Stem Cell Res Ther.

2016 Apr 22;7(1):61.

(IF 5.116)

448. Su H, Jin X, Shen L, Fang Y, Fei Z, Zhang X, Xie C, Chen X .

.

Inhibition of cyclin D1 enhances sensitivity to radiotherapy and reverses epithelial to mesenchymaltransition for esophageal cancer cells.

TUMOR BIOL .

2016 Apr;37(4):5355-63.

(IF 3.65)

449. Liu X, Zhou L, Chen X, Liu T, Pan G, Cui W, Li M, Luo ZP, Pei M, Yang H, Gong Y, He F .

.

Culturing on decellularized extracellular matrix enhances antioxidant properties of human umbilical cord-derived mesenchymal stem cells.

MAT SCI ENG C-MATER.

2016 Apr 1;61:437-48.

(IF 5.88)

450. Cui R, Guan Y, Sun C, Chen L, Bao Y, Li G, Qiu B, Meng X, Pang C, Wang Y .

.

A tumor-suppressive microRNA, miR-504, inhibits cell proliferation and promotes apoptosis by targetingFOXP1 in human glioma.

Cancer Lett.

2016 Apr 28;374(1):1-11.

(IF 7.36)

451. Chen W, Su H, Xu Y, Bao T, Zheng X.

.

Protective effect of wild raspberry (Rubus hirsutus Thunb) extract against acrylamide-induced oxidativedamage is potentiated after simulated gastrointestinal digestion.

Food Chem.

2016 Apr 1;196:943-52.

(IF 6.306)

452. Su S, Liu J, He K, Zhang M, Feng C, Peng F, Li B, Xia X .

.

Overexpression of the long noncoding RNA TUG1 protects against cold-induced injury of mouse livers byinhibitingapoptosis and inflammation.

FEBS J.

2016 Apr;283(7):1261-74.

(IF 4.392)

453. Li Z, Wang B, Tang L, Chen S, Li J .

.

Quinazoline derivative compound (11d)as a novel angiogenesis inhibitor inhibiting VEGFR2

Iran J Basic Med Sci.

2016 Apr;19(4):411-6.

(IF 2.146)

454. Jin F, Qiao C, Luan N, Li H .

.

Lentivirus-mediated PHLDA2 overexpression inhibits trophoblast proliferation, migration and invasion, andinduces apoptosis.

Int J Mol Med.

2016 Apr;37(4):949-57.

(IF 3.098)

455. Wang W, Song XW, Bu XM, Zhang N, Zhao CH .

.

PDCD2 and NCoR1 as putative tumor suppressors in gastric gastrointestinal stromal tumors.

CELL ONCOL.

2016 Apr;39(2):129-37.

(IF 5.304)

456. Han Y, Liu X, Shi B, Xiao R, Gou M, Wang H, Li Q.

.

Identification and characterisation of the immune response properties of Lampetra japonica BLNK.

SCI REP-UK.

2016 Apr 29;6:25308.

(IF 3.998)

457. Cui YY, Yan L, Zhou J, Zhao S, Zheng YB, Sun BH, Lv HT, Rong FN, Chang XT .

.

The role of peptidylarginine deiminase 4 in ovarian cancer cell tumorigenesis and invasion.

TUMOR BIOL .

2016 Apr;37(4):5375-83.

(IF 3.65)

458. Zhang G, Xia F, Zhang Y, Zhang X, Cao Y, Wang L, Liu X, Zhao G, Shi M .

.

Ginsenoside Rd Is Efficacious Against Acute Ischemic Stroke by Suppressing Microglial Proteasome-Mediated Inflammation.

Mol Neurobiol.

2016 May;53(4):2529-40.

(IF 4.5)

459. Liu Y, Wang J, Ni T, Wang L, Wang Y, Sun X .

.

CCL20 mediates RANK/RANKL-induced epithelial-mesenchymal transition in endometrial

ONCOTARGET.

2016 May 3;7(18):25328-39.

(IF 5.168)

460. Fu Y, Lin T, Liang A, Hu F.

.

Effects of recombinant baculovirus AcMNPV-BmK IT on the formation of early cables

Cytotechnology.

2016 May;68(3):381-7.

(IF 1.777)

461. Zhang M, Li L, Xie W, Wu JF, Yao F, Tan YL, Xia XD, Liu XY, Liu D, Lan G, Zeng MY, Gong D, Cheng HP, Huang C, Zhao ZW, Zheng XL, Tang CK .

.

Apolipoprotein A-1 binding protein promotes macrophage cholesterol efflux by facilitating apolipoprotein A-1 binding to ABCA1 and preventing ABCA1 degradation.

Atherosclerosis.

2016 May;248:149-59.

(IF 3.919)

462. Wang R, Ma L, Weng D, Yao J, Liu X, Jin F.

.

Gallic acid induces apoptosis and enhances the anticancer effects of cisplatin in human small cell lung cancer H446 cell line via the ROS-dependent mitochondrial apoptotic pathway.

Oncol Rep.

2016 May;35(5):3075-83.

(IF 3.417)

463. Xu T, Qin L, Zhu Z, Wang X, Liu Y, Fan Y, Zhong S, Wang X, Zhang X, Xia L, Zhang X, Xu C, Shen Z.

.

MicroRNA-31 functions as a tumor suppressor and increases sensitivity to mitomycin-C in urothelialbladder cancer by targeting integrin α5.

ONCOTARGET.

2016 May 10;7(19):27445-57.

(IF 5.168)

464. Xie W, Wang M, Chen C, Zhang X, Melzig MF .

.

Hepatoprotective effect of isoquercitrin against acetaminophen-induced liver injury.

Life Sci.

2016 May 1;152:180-9.

(IF 3.647)

465. Zhang LY, Xue HG, Chen JY, Chai W, Ni M .

.

Genistein induces adipogenic differentiation in human bone marrow mesenchymal stem cells andsuppresses their osteogenic potential by upregulating PPARγ.

Exp Ther Med.

2016 May;11(5):1853-1858.

(IF 1.785)

466. Hong Y, Shen C, Yin Q, Sun M, Ma Y, Liu X .

.

Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-β Metabolism and AGEs-Induced

Neurochem Res.

2016 May;41(5):1192-9.

(IF 3.038)

467. Xie T, Ren HY, Lin HQ, Mao JP, Zhu T, Wang SD, Ye ZM .

.

Sinomenine prevents metastasis of human osteosarcoma cells via S phase arrest and suppression oftumor-related neovascularization and osteolysis through the CXCR4-STAT3 pathway.

Int J Oncol.

2016 May;48(5):2098-112.

(IF 3.899)

468. Wang Y, Huang HY, Yang L, Zhang Z, Ji H .

.

Cetuximab-modified mesoporous silica nano-medicine specifically targets EGFR-mutant lung cancer andovercomes drug resistance.

SCI REP-UK.

2016 May 6;6:25468.

(IF 3.998)

469. Wu J, Zhang M, Li H, Sun X, Hao S, Ji M, Yang J, Li K .

.

BDNF pathway is involved in the protective effects of SS-31 on isoflurane-induced

Behav Brain Res.

2016 May 15;305:115-21.

(IF 2.977)

470. Yu H, Guan Q, Guo L, Zhang H, Pang X, Cheng Y, Zhang X, Sun Y.

.

Gypenosides alleviate myocardial ischemia-reperfusion injury via attenuation of oxidative stress andpreservation of mitochondrial function in rat heart.

CELL STRESS CHAPERON.

2016 May;21(3):429-37.

(IF 2.892)

471. Guo W, Yu D, Wang X, Luo C, Chen Y, Lei W, Wang C, Ge Y, Xue W, Tian Q, Gao X, Yao W .

.

Anti-inflammatory effects of interleukin-23 receptor cytokine-binding homology region rebalance T celldistribution in rodent collagen-induced arthritis.

ONCOTARGET.

2016 May 31;7(22):31800-13.

(IF 5.168)

472. Wu-jiao Bai, Peng-jing Jin, Mei-qian Kuang, Quan-wei Wei, Fang-xiong Shi, John S. Davis, Da-gan Mao.

.

Temporal regulation of extracellular signal-regulated kinase 1/2 phosphorylation, heat shock protein 70 and activating transcription factor 3 during prostaglandin F-induced luteal regression in pseudopregnant rats following heat stress.

REPROD FERT DEVELOP.

12 May 2016, 29(6) 1184-1193.

(IF 1.718)

473. Zhang W, Ni P, Mou C, Zhang Y, Guo H, , Zhao T, Loh YH, Chen L.

.

Cops2 promotes pluripotency maintenance by Stabilizing Nanog Protein and Repressing Transcription.

SCI REP-UK.

2016 May 26;6:26804.

(IF 3.998)

474. Chen Q, Bei JJ, Liu C, Feng SB, Zhao WB, Zhou Z, Yu ZP, Du XJ, Hu HY.

.

HMGB1 Induces Secretion of Matrix Vesicles by Macrophages to Enhance Ectopic

PLoS One.

2016 May 31;11(5):e0156686.

(IF 2.74)

475. Chen XY, Xia HX, Guan HY, Li B, Zhang W.

.

Follicle Loss and Apoptosis in Cyclophosphamide-Treated Mice: What's the Matter?

Int J Mol Sci.

2016 May 30;17(6). pii: E836.

(IF 4.556)

476. Li J, Feng Z, Chen L, Wang X, Deng H.

.

MicroRNA-335-5p inhibits osteoblast apoptosis induced by high glucose.

Mol Med Rep.

2016 May;13(5):4108-12.

(IF 2.1)

477. Li Y, Shi S, Gao J, Han S, Wu X, Jia Y, Su L, Shi J, Hu D.

.

Cryptotanshinone downregulates the profibrotic activities of hypertrophic scar fibroblasts and accelerateswound healing: A potential therapy for the reduction of skin scarring.

Biomed Pharmacother.

2016 May;80:80-6.

(IF 4.545)

478. Wang G, Zhang L, Chen X, Xue X, Guo Q, Liu M, Zhao J.

.

Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells.

SCI REP-UK.

2016 May 13;6:25946.

(IF 3.998)

479. Wang S, Xie J, Li J, Liu F, Wu X, Wang Z .

.

Cisplatin suppresses the growth and proliferation of breast and cervical cancer cell lines by inhibitingintegrin β5-mediated glycolysis.

Am J Cancer Res.

2016 May 1;6(5):1108-17.

(IF 5.177)

480. Cao J, Wang H, Chen F, Fang J, Xu A, Xi W, Zhang S, Wu G, Wang Z .

.

Galangin inhibits cell invasion by suppressing the epithelial-mesenchymal transition and inducing apoptosisin renal cell carcinoma.

Mol Med Rep.

2016 May;13(5):4238-44.

(IF 2.1)

481. Hua K, Jin J, Zhao J, Song J, Song H, Li D, Maskey N, Zhao B, Wu C, Xu H, Fang L.

.

miR-135b, upregulated in breast cancer, promotes cell growth and disrupts the cell cycle by regulatingLATS2.

Int J Oncol.

2016 May;48(5):1997-2006.

(IF 3.899)

482. Wang L, He J, Xu H, Xu L, Li N.

.

MiR-143 targets CTGF and exerts tumor-suppressing functions in epithelial ovarian cancer.

Am J Transl Res.

2016 Jun 15;8(6):2716-26.

(IF 3.375)

483. Xie N, Wang C, Wu C, Cheng X, Gao Y, Zhang H, Zhang Y, Lian Y .

.

Mdivi-1 Protects Epileptic Hippocampal Neurons from Apoptosis via Inhibiting Oxidative Stress andEndoplasmic Reticulum Stress in Vitro.

Neurochem Res.

2016 Jun;41(6):1335-42.

(IF 3.038)

484. Yang Yang, Yanyan Sun, Laiyang Cheng, Anna Li, Yanjun Shen, Ligang Jiang, Xiaohui Deng, Lan Chao.

.

GRIM-19, a gene associated with retinoid-interferon-induced mortality, affects endometrial receptivity and embryo implantation.

REPROD FERT DEVELOP.

27 June 2016.

(IF 1.718)

485. Zhao X, Zhou Y, Chen YU, Yu F.

.

miR-494 inhibits ovarian cancer cell proliferation and promotes apoptosis by targeting FGFR2.

Oncol Lett.

2016 Jun;11(6):4245-4251.

(IF 2.311)

486. Zhai Q, Huang B, Dong H, Zhao Q, Zhu S, Liang S, Li S, Yang S, Han H .

.

Molecular Characterization and Immune Protection of a New Conserved Hypothetical Protein

PLoS One.

2016 Jun 16;11(6):e0157678.

(IF 2.74)

487. Lin Y, Wang P, Liu YH, Shang XL, Chen LY, Xue YX.

.

DT(270-326) , a Truncated Diphtheria Toxin, Increases Blood-Tumor Barrier Permeability

CNS Neurosci Ther.

2016 Jun;22(6):477-87.

(IF 4.074)

488. Zhai JW, Gao C, Ma WD, Wang W, Yao LP, Xia XX, Luo M, , Zu YG, Fu YJ .

.

Geraniin induces apoptosis of human breast cancer cells MCF-7 via ROS-mediated stimulation of p38MAPK.

TOXICOL MECH METHOD.

2016 Jun;26(5):311-8.

(IF 2.295)

489. Lu Y, Xu S, Chen H, He M, Deng Y, Cao Z, Pi H, Chen C, Li M, Ma Q, Gao P, Ji Y, Zhang L, Yu Z, Zhou Z .

.

CdSe/ZnS quantum dots induce hepatocyte pyroptosis and liver inflammation via NLRP3 inflammasomeactivation.

Biomaterials.

2016 Jun;90:27-39.

(IF 10.317)

490. Ding X, Wang X, Lin M, Xing Y, Ge S, Jia R, Zhang H, Fan X, Li J .

.

PAUPAR lncRNA suppresses tumourigenesis by H3K4 demethylation in uveal melanoma.

FEBS Lett.

2016 Jun;590(12):1729-38.

(IF 3.057)

491. Jiang Y, Xu H, Wang J.

.

Alantolactone induces apoptosis of human cervical cancer cells via reactive oxygen species generation,glutathione depletion and inhibition of the Bcl-2/Bax signaling pathway.

Oncol Lett.

2016 Jun;11(6):4203-4207.

(IF 2.311)

492. Wu ZH, Tao ZH, Zhang J, Li T, Ni C, Xie J, Zhang JF, Hu XC .

.

MiRNA-21 induces epithelial to mesenchymal transition and gemcitabine resistance via the PTEN/AKTpathway in breast cancer.

TUMOR BIOL .

2016 Jun;37(6):7245-54.

(IF 3.65)

493. Ma Z, Ma Y, Xia Q, Li Y, Li R, Chang W, Chen J, Leng Z, Tao K.

.

MicroRNA-155 expression inversely correlates with pathologic stage of gastric cancer and it inhibits gastriccancer cell growth by targeting cyclin D1.

J CANCER RES CLIN.

2016 Jun;142(6):1201-12.

(IF 3.656)

494. Qin WD, Liu GL, Wang J, Wang H, Zhang JN, Zhang F, Ma Y, Ji XY, Li C, Zhang MX .

.

Poly(ADP-ribose) polymerase 1 inhibition protects cardiomyocytes from inflammation and apoptosis indiabetic cardiomyopathy.

ONCOTARGET.

2016 Jun 14;7(24):35618-35631.

(IF 5.168)

495. Wang W, Liu M, Guan Y, Wu Q.

.

Hypoxia-Responsive Mir-301a and Mir-301b Promote Radioresistance of Prostate Cancer Cells viaDownregulating NDRG2.

MED SCI MONITOR.

2016 Jun 21;22:2126-32.

(IF 1.918)

496. Gao X, Wang J, Bai W, Ji W, Wang L .

.

NOB1 silencing inhibits the growth and metastasis of laryngeal cancer cells through the regulation of JNKsignaling pathway.

Oncol Rep.

2016 Jun;35(6):3313-20.

(IF 3.417)

497. Liu D, Zhang N, Zhang J, Zhao H, Wang X.

.

miR-410 suppresses the expression of interleukin-6 as well as renal fibrosis in the pathogenesis of lupusnephritis.

CLIN EXP PHARMACOL P .

2016 Jun;43(6):616-25.

(IF 2.092)

498. Gu H, Liu M, Ding C, Wang X, Wang R, Wu X, Fan R .

.

Hypoxia-responsive miR-124 and miR-144 reduce hypoxia-induced autophagy and enhance radiosensitivityof prostate cancer cells via suppressing PIM1.

CANCER MED-US.

2016 Jun;5(6):1174-82.

(IF 3.491)

499. Liu P, Ye F, Xie X, Li X, Tang H, Li S, Huang X, Song C, Wei W, Xie X.

.

mir-101-3p is a key regulator of tumor metabolism in triple negative breast cancer targeting AMPK.

ONCOTARGET.

2016 Jun 7;7(23):35188-98.

(IF 5.168)

500. Peng YY, He YH, Chen C, Xu T, Li L, Ni MM, Meng XM, Huang C, Li J4.

.

NLRC5 regulates cell proliferation, migration and invasion in hepatocellular carcinoma by targeting the Wnt/β-catenin signaling pathway.

Cancer Lett.

2016 Jun 28;376(1):10-21.

(IF 7.36)

501. Wang QY, Zhong H, Chen FY, Zhang MY, Cai JY, Zhong JH .

.

A preliminary study on epigenetic regulation of Acanthopanax senticosus in leukemia cell lines.

Exp Hematol.

2016 Jun;44(6):466-73.

(IF 2.82)

502. Zhang X, Hu W, Feng F, Xu J, Wu F .

.

Apelin-13 protects against myocardial infarction-induced myocardial fibrosis.

Mol Med Rep.

2016 Jun;13(6):5262-8.

(IF 2.1)

503. Li X, Cen Y, Cai Y, Liu T, Liu H, Cao G, Liu D, Li B, Peng W, Zou J, Pang X4, Zheng J, Zhou H .

.

TLR9-ERK-mTOR signaling is critical for autophagic cell death induced by CpG oligodeoxynucleotide 107combined with irradiation in glioma cells.

SCI REP-UK.

2016 Jun 2;6:27104.

(IF 3.998)

504. Liu Q, Zhang Z, Zheng Z, Zheng C, Liu Y, Hu Q, Ke X, Wang H.

.

Human Bocavirus NS1 and NS1-70 Proteins Inhibit TNF-α-Mediated Activation of NF-κB by targeting p65.

SCI REP-UK.

2016 Jun 22;6:28481.

(IF 3.998)

505. Yang H, Yang R, Liu H, Ren Z, Kong F, Li D, Ma X .

.

Synergism between PGC-1α and estrogen in the survival of endometrial

ONCOTARGETS THER.

2016 Jun 30;9:3963-73.

(IF 3.337)

506. Xu L, Wang X, Wang J, Liu D, Wang Y, Huang Z, Tan H .

.

Hypoxia-induced secretion of IL-10 from adipose-derived mesenchymal stem cell promotes growth andcancer stem cell properties of Burkitt lymphoma.

TUMOR BIOL .

2016 Jun;37(6):7835-42.

(IF 3.65)

507. Zhang MJ, Zhou Y, Chen L, Wang X, Pi Y, Long CY, Sun MJ, Chen X, Gao CY, Li JC, Zhang LL.

.

Impaired SIRT1 promotes the migration of vascular smooth muscle cell-derived foam cells.

Histochem Cell Biol.

2016 Jul;146(1):33-43.

(IF 3.418)

508. Sun JY, Li DL, Dong Y, Zhu CH, Liu J, Li JD, Zhou T, Gou JZ, Li A, Zang WJ.

.

Baicalin inhibits toll-like receptor 2/4 expression and downstream signaling in rat experimentalperiodontitis.

Int Immunopharmacol.

2016 Jul;36:86-93.

(IF 3.943)

509. Yao S, Tian C, Ding Y, Ye Q, Gao Y, Yang N, Li Q.

.

Down-regulation of Krüppel-like factor-4 by microRNA-135a-5p promotes proliferation and metastasis in hepatocellular carcinoma by transforming growth factor-β1.

ONCOTARGET.

2016 Jul 5;7(27):42566-42578.

(IF 5.168)

510. Deng H, Zeng J, Zhu Y, Ye T, Xia Y, Shi Y, Wang N, Zhang L, Song X, Zuo W, Gao T, Yu L.

.

A novel small-molecule YLT256 inhibits proliferation and induces apoptosis both in vitro and in vivo in solidtumors.

Biomed Pharmacother.

2016 Jul;81:482-90.

(IF 4.545)

511. Lu YZ, Li PF, Li YZ, Luo F, Guo C, Lin B, Cao XW, Zhao J, Wang FJ .

.

Enhanced anti-tumor activity of trichosanthin after combination with a human-derived cell-penetratingpeptide, and a possible mechanism of activity.

Fitoterapia.

2016 Jul;112:183-90.

(IF 2.527)

512. Zhang CG, Yang SD, Zhu WJ, You BG, Liu Y, Yuan ZQ, Chen WL, Li JZ, Zhou XF, Liu C, Zhang XN .

.

Distinctive polymer micelle designed for siRNA delivery and reversal of MDR1 gene-dependent multidrugresistance.

J BIOMED MATER RES B.

2016 Jul 13.doi: 10.1002/jbm.b.33748. [Epub ahead of print]

(IF 2.831)

513. Chen L, Zheng H, Zhang S .

.

Involvement of upregulation of miR-210 in a rat epilepsy model.

Neuropsychiatr Dis Treat.

2016 Jul 13;12:1731-7.

514. Shi X, Li Y, Hu J, Yu B .

.

Tert-butylhydroquinone attenuates the ethanol-induced apoptosis of and activates the Nrf2 antioxidantdefense pathway in H9c2 cardiomyocytes.

Int J Mol Med.

2016 Jul;38(1):123-30.

(IF 3.098)

515. Wu L, Bao K, Song R, Wang D, Zhang L, Wang W, Zhang W, Bin W .

.

Development of Novel Erythromycin Derivatives with Inhibitory Activity against Proliferation

PLoS One.

2016 Jul 22;11(7):e0159503.

(IF 2.74)

516. Cao Z, Fang Y, Lu Y, Qian F, Ma Q, He M, Pi H, Yu Z, Zhou Z .

.

Exposure to nickel oxide nanoparticles induces pulmonary inflammation through NLRP3 inflammasomeactivation in rats.

INT J NANOMED.

2016 Jul 22;11:3331-46.

(IF 5.115)

517. Yan X, Wu L, Li B, Meng X, Dai H, Zheng Y, Fu J.

.

Cyanidin-3-O-glucoside Induces Apoptosis and Inhibits Migration of Tumor Necrosis Factor-α-Treated Rat Aortic Smooth Muscle Cells.

Cardiovasc Toxicol.

2016 Jul;16(3):251-9.

(IF 2.284)

518. Li L, Tang S, Tang X .

.

Thymic Stromal Lymphopoietin Promotes Fibrosis and Activates Mitogen-Activated Protein Kinases in MRC-5 Cells.

MED SCI MONITOR.

2016 Jul 6;22:2357-62.

(IF 1.918)

519. Lin X, Wei J, Chen Y, He P, Lin J, Tan S, Nie J, Lu S, He M, Lu Z, Huang Q .

.

Isoorientin from Gypsophila elegans induces apoptosis in liver cancer cells via mitochondrial-mediatedpathway.

J Ethnopharmacol.

2016 Jul 1;187:187-94.

(IF 3.69)

520. Zou D, Geng N, Chen Y, Ren L, Liu X, Wan J, Guo S, Wang S .

.

Ranolazine improves oxidative stress and mitochondrial function in the atrium of acetylcholine-CaCl2 induced atrial fibrillation rats.

Life Sci.

2016 Jul 1;156:7-14.

(IF 3.647)

521. He X, Liao Y, Lu W, Xu G, Tong H, Ke J, Wan X .

.

Elevated STMN1 promotes tumor growth and invasion in endometrial carcinoma.

TUMOR BIOL .

2016 Jul;37(7):9951-8.

(IF 3.65)

522. Zeng Q, Wang Z, Liu C, Gong Z, Yang L, Jiang L, Ma Z, Qian Y, Yang Y, Kang H, Hong S, Bu Y, Hu G .

.

Knockdown of NFBD1/MDC1 enhances chemosensitivity to cisplatin or 5-fluorouracil in nasopharyngeal carcinoma CNE1 cells.

Mol Cell Biochem.

2016 Jul;418(1-2):137-46.

(IF 2.795)

523. Xiang J, Cheng S, Feng T, Wu Y, Xie W, Zhang M, Xu X, Zhang C.

.

Neotuberostemonine attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment andactivation of macrophages.

Int Immunopharmacol.

2016 Jul;36:158-64.

(IF 3.943)

524. Li BS, Guo WJ, Hong L, Liu YD, Liu C, Hong SS, Wu DB, Min J.

.

Role of mechanical strain-activated PI3K/Akt signaling pathway in pelvic organ prolapse.

Mol Med Rep.

2016 Jul;14(1):243-53.

(IF 2.1)

525. Lv L, Liu HG, Dong SY, Yang F, Wang QX, Guo GL, Pan YF, Zhang XH .

.

Upregulation of CD44v6 contributes to acquired chemoresistance via the modulation of autophagy in coloncancer SW480 cells.

TUMOR BIOL .

2016 Jul;37(7):8811-24.

(IF 3.65)

526. Li X, Jin Q, Wu YL, Sun P, Jiang S, Zhang Y, Zhang DQ, Zhang YJ, Lian LH, Nan JX .

.

Tetrandrine regulates hepatic stellate cell activation via TAK1 and NF-κB signaling.

Int Immunopharmacol.

2016 Jul;36:263-70.

(IF 3.943)

527. Yan X, Wu L, Li B, Meng X, Dai H, Zheng Y, Fu J .

.

Cyanidin-3-O-glucoside Induces Apoptosis and Inhibits Migration of Tumor Necrosis Factor-α-Treated RatAortic Smooth Muscle Cells.

Cardiovasc Toxicol.

2016 Jul;16(3):251-9.

(IF 2.284)

528. Liu B, Shi Y, Peng W, Zhang Q, Liu J, Chen N, Zhu R .

.

Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells.

Mol Med Rep.

2016 Jul;14(1):159-64.

(IF 2.1)

529. Yue H, Zhu J, Xie S, Li F, Xu Q .

.

MDC1-AS, an antisense long noncoding RNA, regulates cell proliferation of glioma.

Biomed Pharmacother.

2016 Jul;81:203-9.

(IF 4.545)

530. Wang J, Wang QL, Nong XH, Zhang XY, Xu XY, Qi SH, Wang YF.

.

Oxalicumone A, a new dihydrothiophene-condensed sulfur chromone induces apoptosis in leukemia cellsthrough endoplasmic reticulum stress pathway.

Eur J Pharmacol.

2016 Jul 15;783:47-55.

(IF 3.263)

531. Wang X, Chen J, Wang J, Yu F, Zhao S, Zhang Y, Tang H, Peng Z .

.

Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation

BMC Cancer.

2016 Jul 4;16:383.

(IF 3.15)

532. Wu H, Zu S, Sun X, Liu Y, Tian J, Qu L.

.

N-Terminal Domain of Feline Calicivirus (FCV) Proteinase-Polymerase Contributes to the Inhibition of HostCell Transcription.

VIRUSES-BASEL.

2016 Jul 20;8(7). pii: E199.

(IF 3.816)

533. Zhang Y, Lin L, Jin Y, Lin Y, Cao Y, Zheng C.

.

Overexpression of WNT5B promotes COLO 205 cell migration and invasion through the JNK signalingpathway.

Oncol Rep.

2016 Jul;36(1):23-30.

(IF 3.417)

534. Zhang Q, Ma S, Liu B, Liu J, Zhu R, Li M.

.

Chrysin induces cell apoptosis via activation of the p53/Bcl-2/caspase-9 pathway

Exp Ther Med.

2016 Jul;12(1):469-474.

(IF 1.785)

535. Li Y, Chi G, Shen B, Tian Y, Feng H .

.

Isorhamnetin ameliorates LPS-induced inflammatory response through downregulation of NF-κB signaling.

Inflammation.

2016 Aug;39(4):1291-301.

(IF 3.212)

536. Bu XN, Qiu C, Wang C, Jiang Z .

.

Inhibition of DACH1 activity by short hairpin RNA represses cell proliferation and tumor invasion inpancreatic cancer.

Oncol Rep.

2016 Aug;36(2):745-54.

(IF 3.417)

537. Guo C, Li C, Yang K, Kang H, Xu X, Xu X, Deng L.

.

Increased EZH2 and decreased osteoblastogenesis during local irradiation-induced bone loss in rats.

SCI REP-UK.

2016 Aug 8;6:31318.

(IF 3.998)

538. Xu G, Zhang X, Gao W, Wang C, Wang J, Sun H, Sun Y, Guo L, Zhang R, Chang KC, Liu J, Pu J .

.

Prevailing PA Mutation K356R in Avian Influenza H9N2 Virus Increases Mammalian Replication andPathogenicity.

J Virol.

2016 Aug 26;90(18):8105-14.

(IF 4.501)

539. Li J, Yang X, Guan H, Mizokami A, Keller ET, Xu X, Liu X, Tan J, Hu L, Lu Y, Zhang J.

.

Exosome-derived microRNAs contribute to prostate cancer chemoresistance.

Int J Oncol.

2016 Aug;49(2):838-46.

(IF 3.899)

540. Song Y, Yuan L, Wang Y, Chen M, Deng J, Lv Q, Sui T, Li Z, Lai L .

.

Efficient dual sgRNA-directed large gene deletion in rabbit with CRISPR/Cas9 system.

Cell Mol Life Sci.

2016 Aug;73(15):2959-68.

(IF 6.496)

541. Zhu C, Zheng XF, Yang YH, Li B, Wang YR, Jiang SD, Jiang LS .

.

LGR4 acts as a key receptor for R-spondin 2 to promote osteogenesis through Wnt signaling pathway.

Cell Signal.

2016 Aug;28(8):989-1000.

(IF 3.968)

542. Tian T, Zhou Y, Feng X, Ye S, Wang H, Wu W, Tan W, Yu C, Hu J, Zheng R, Chen Z, Pei X, Luo H.

.

MicroRNA-16 is putatively involved in the NF-κB pathway regulation in ulcerative colitis

SCI REP-UK.

2016 Aug 1;6:30824.

(IF 3.998)

543. Zhu S, Cao J, Sun H, Liu K, Li Y, Zhao T.

.

p18 inhibits reprogramming through inactivation of Cdk4/6.

SCI REP-UK.

2016 Aug 3;6:31085.

(IF 3.998)

544. Li X, Liu R, Yu L, Yuan Z, Sun R, Yang H, Zhang L, Jiang Z .

.

Alpha-naphthylisothiocyanate impairs bile acid homeostasis through AMPK-FXR pathways in rat primaryhepatocytes.

Toxicology.

2016 Aug 31;370:106-115.

(IF 4.099)

545. Peng L, Shu X, Lang C, Yu X .

.

Effects of hypoxia on proliferation of human cord blood-derived mesenchymal stem cells.

Cytotechnology.

2016 Aug;68(4):1615-22.

(IF 1.777)

546. Wei LJ, Tan X, Fan GJ, Jiang YN, Shah QA.

.

Role of the NOD1/NF-κB pathway on bovine neutrophil responses to crude lipopolysaccharide.

Vet J.

2016 Aug;214:24-31.

(IF 2.115)

547. Liu Y, Li Y, Li N, Teng W, Wang M, Zhang Y, Xiao Z .

.

TGF-β1 promotes scar fibroblasts proliferation and transdifferentiation via up-regulating MicroRNA-21.

SCI REP-UK.

2016 Aug 24;6:32231.

(IF 3.998)

548. Deng QW, Yang H, Yan FL, Wang H, Xing FL, Zuo L, Zhang HQ.

.

Blocking Sympathetic Nervous System Reverses Partially Stroke-Induced Immunosuppression

Neurochem Res.

2016 Aug;41(8):1877-86.

(IF 3.038)

549. Peng Z, Wu T, Li Y, Xu Z, Zhang S, Liu B, Chen Q, Tian D.

.

MicroRNA-370-3p inhibits human glioma cell proliferation and induces cell cycle arrest by directly targetingβ-catenin.

Brain Res.

2016 Aug 1;1644:53-61.

(IF 2.733)

550. Dai C, Li D, Gong L, Xiao X, Tang S .

.

Curcumin Ameliorates Furazolidone-Induced DNA Damage and Apoptosis in Human Hepatocyte L02 Cells by Inhibiting ROS Production and Mitochondrial Pathway.

Molecules.

2016 Aug 22;21(8). pii: E1061.

(IF 3.267)

551. Cong L, Chen W.

.

Neuroprotective Effect of Ginsenoside Rd in Spinal Cord Injury Rats.

BASIC CLIN PHARMACOL.

2016 Aug;119(2):193-201.

(IF 2.651)

552. Yin W, Wei X, Jiang J, Fan K, Zhao J, Sun N, Wang Z, Sun Y, Ma H, Zhao X, Li H .

.

Complement receptor activity of recombinant porcine CR1-like protein expressed in a eukaryotic system.

Immunol Res.

2016 Aug;64(4):1025-32.

(IF 2.507)

553. Huang W, Liu Z, Zhou G, Ling J, Tian A, Sun N .

.

Silencing Bag-1 gene via magnetic gold nanoparticle-delivered siRNA plasmid for colorectal cancer therapyin vivo and in vitro.

TUMOR BIOL .

2016 Aug;37(8):10365-74.

(IF 3.65)

554. Miao L, Shen X, Whiteman M, Xin H, Shen Y, Xin X, Moore PK, Zhu YZ .

.

Hydrogen Sulfide Mitigates Myocardial Infarction via Promotion of Mitochondrial Biogenesis-Dependent M2Polarization of Macrophages.

ANTIOXID REDOX SIGN.

2016 Aug 10;25(5):268-81.

(IF 6.323)

555. Hu H, Zheng N, Gao H, Dai W, Zhang Y, Li S, Wang J .

.

Immortalized bovine mammary epithelial cells express stem cell markers and differentiate in

Cell Biol Int.

2016 Aug;40(8):861-72.

(IF 2.571)

556. Xu L, He S, Yin P, Li D, Mei C, Yu X, Shi Y, Jiang L, Liu F .

.

Punicalagin induces Nrf2 translocation and HO-1 expression via PI3K/Akt, protecting rat intestinal epithelialcells from oxidative stress.

INT J HYPERTHER.

2016 Aug;32(5):465-73.

(IF 3.574)

557. Sun HM, Mi YS, Yu FD, Han Y, Liu XS, Lu S, Zhang Y, Zhao SL, Ye L, Liu TT, Yang DH, Sun XF, Qin XB, Zhou ZG, Tang HM, Peng ZH .

.

SERPINA4 is a novel independent prognostic indicator and a potential therapeutic target for

Am J Cancer Res.

2016 Aug 1;6(8):1636-49.

(IF 5.177)

558. Wu J, Chen X, Ye H, Yao M, Li S, Chen L .

.

Nonstructural protein (NS1) of human parvovirus B19 stimulates host innate

Virus Res.

2016 Aug 15;222:48-52.

(IF 2.934)

559. Yu J, Li X, Yang J, Wu Y, Li B .

.

Effects of Simazine Exposure on Neuronal Development-Related Factors in MN9D Cells.

MED SCI MONITOR.

2016 Aug 11;22:2831-8.

(IF 1.918)

560. Yu S, Zheng S, Leng J, Wang S, Zhao T, Liu J .

.

Inhibition of mitochondrial calcium uniporter protects neurocytes from ischemia/reperfusion injury via theinhibition of excessive mitophagy.

Neurosci Lett.

2016 Aug 15;628:24-9.

(IF 2.274)

561. Xu X, Cheng K, Cheng W, Zhou T, Jiang M, Xu J.

.

Isolation and chatacterization of homoisoflavonoids from Dracaena cochinchinensis and their osteogenicactivities in mouse mesenchymal stem cells.

J PHARMACEUT BIOMED.

2016 Sep 10;129:466-72.

(IF 3.209)

562. Su X, Ren Y, Yu N, Kong L, Kang J.

.

Thymoquinone inhibits inflammation, neoangiogenesis and vascular remodeling in asthma mice.

Int Immunopharmacol.

2016 Sep;38:70-80.

(IF 3.943)

563. Cai G, Ma X, Chen B, Huang Y, Liu S, Yang H, Zou W .

.

Galectin-3 induces ovarian cancer cell survival and chemoresistance via TLR4 signaling

TUMOR BIOL .

2016 Sep;37(9):11883-11891.

(IF 3.65)

564. Dong Y, Cui P, Li Z, Zhang S .

.

Aging asymmetry: systematic survey of changes in age-related biomarkers in the annual fishNothobranchius guentheri.

Fish Physiol Biochem.

2016 Sep 10.[Epub ahead of print]

(IF 2.242)

565. Zhao R, Li Y, Lin Z, Wan J, Xu C, Zeng Y, Zhu Y .

.

miR-199b-5p modulates BMSC osteogenesis via suppressing GSK-3β/β-catenin signaling pathway.

BIOCHEM BIOPH RES CO.

2016 Sep 2;477(4):749-54.

(IF 2.985)

566. Guo W, Sui QQ, Gao XF, Feng JF, Zhu J, He C, Knight GE, Burnstock G, Xiang Z .

.

Co-localization of Pirt protein and P2X2 receptors in the mouse enteric nervous system.

PURINERG SIGNAL.

2016 Sep;12(3):489-96.

(IF 3.065)

567. Gao D, Zhang YL, Yang FQ, Li F, Zhang QH, Xia ZN .

.

The flower of Edgeworthia gardneri (wall.) Meisn. suppresses adipogenesis through

J Ethnopharmacol.

2016 Sep 15;191:379-86.

(IF 3.69)

568. Song G, Shen Y, Ruan Z, Li X, Chen Y, Yuan W, Ding X, Zhu L, Qian L.

.

LncRNA-uc.167 influences cell proliferation, apoptosis and differentiation of P19 cells by regulating Mef2c.

Gene.

2016 Sep 15;590(1):97-108.

(IF 2.984)

569. Yin Y, Dou X, Duan S, Zhang L, Xu Q, Li H, Li D .

.

Downregulation of cell division cycle 25 homolog C reduces the radiosensitivity and proliferation activity ofesophageal squamous cell carcinoma.

Gene.

2016 Sep 30;590(2):244-9.

(IF 2.984)

570. Pan L, Yao DC, Yu YZ, Li SJ, Chen BJ, Hu GH, Xi C, Wang ZH, Wang HY, Li JH, Tu YS .

.

Necrostatin-1 protects against oleic acid-induced acute respiratory distress syndrome in rats.

BIOCHEM BIOPH RES CO.

2016 Sep 30;478(4):1602-8.

(IF 2.985)

571. Yuan P, Cao W, Zang Q, Li G, Guo X, Fan J .

.

The HIF-2α-MALAT1-miR-216b axis regulates multi-drug resistance of hepatocellular

BIOCHEM BIOPH RES CO.

2016 Sep 23;478(3):1067-73.

(IF 2.985)

572. Zhang L, Li Z, Shi T, La X, Li H, Li Z .

.

Design, purification and assessment of GRP78 binding peptide-linked Subunit A of Subtilase cytotoxic fortargeting cancer cells.

BMC Biotechnol.

2016 Sep 1;16(1):65.

(IF 2.312)

573. Kang YF, Qiao HX, Xin LZ, Ge LP .

.

Chain elongation analog of resveratrol as potent cancer chemoprevention agent.

J Physiol Biochem.

2016 Sep;72(3):445-52.

(IF 2.952)

574. Yang T, Wang Y, Jiang S, Liu X, Yu Z .

.

Hepatocyte growth factor-induced differentiation of bone mesenchymal stem cells toward hepatocyte-likecells occurs through nuclear factor-kappa B signaling in vitro.

Cell Biol Int.

2016 Sep;40(9):1017-23.

(IF 2.571)

575. Wang X, Liu B, Dou Y, Fan H, Wang S, Li T, Ding C, Yu S .

.

The Riemerella anatipestifer AS87_01735 Gene Encodes Nicotinamidase PncA, an Important VirulenceFactor.

APPL ENVIRON MICROB.

2016 Sep 16;82(19):5815-23.

(IF 4.016)

576. Dai C, Li B, Zhou Y, Li D, Zhang S, Li H, Xiao X, Tang S.

.

Curcumin attenuates quinocetone induced apoptosis and inflammation via the opposite modulation ofNrf2/HO-1 and NF-kB pathway in human hepatocyte L02 cells.

Food Chem Toxicol.

2016 Sep;95:52-63.

(IF 4.679)

577. Han Y, Liao X, Gao Z, Yang S, Chen C, Liu Y, Wang WE, Wu G, Chen X, Jose PA, Zhang Y, Zeng C .

.

cTnI Exacerbates Myocardial Ischemia/Reperfusion Injury by Inducing Adhesion of Monocytes to VECs via TLR4/NF-κB-dependent Pathway.

CLIN SCI.

2016 Sep 28. pii: CS20160373.

(IF 5.223)

578. Dai C, Tang S, Velkov T, Xiao X.

.

Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species, Mitochondrial Dysfunction, and Autophagy.

Mol Neurobiol.

2016 Sep;53(7):4685-700.

(IF 4.5)

579. Wang XX, Zha YY, Yang B, Chen L, Wang M .

.

Suppression of synaptic plasticity by fullerenol in rat hippocampus in vitro.

INT J NANOMED.

2016 Sep 28;11:4947-4955.

(IF 5.115)

580. Dai C, Tang S, Velkov T, Xiao X .

.

Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species,Mitochondrial Dysfunction, and Autophagy.

Mol Neurobiol.

2016 Sep;53(7):4685-700.

(IF 4.5)

581. Li J, An G, Zhang M, Ma Q .

.

Long non-coding RNA TUG1 acts as a miR-26a sponge in human glioma cells.

BIOCHEM BIOPH RES CO.

2016 Sep 2;477(4):743-8.

(IF 2.985)

582. Liu YW, Zhang L, Li Y, Cheng YQ, Zhu X, Zhang F, Yin XX.

.

Activation of mTOR signaling mediates the increased expression of AChE in high glucose condition: in vitroand in vivo evidences.

Mol Neurobiol.

2016 Sep;53(7):4972-80.

(IF 4.5)

583. Fan YL, Li HC, Zhao W, Peng HH, Huang F, Jiang WH, Xu SY.

.

Curcumin Attenuated Bupivacaine-Induced Neurotoxicity in SH-SY5Y Cells Via Activation of the AktSignaling Pathway.

Neurochem Res.

2016 Sep;41(9):2425-32.

(IF 3.038)

584. Li X, Wu Y, Liu A, Tang X.

.

MiR-27b is epigenetically downregulated in tamoxifen resistant breast cancer cells due to promotermethylation and regulates tamoxifen sensitivity by targeting HMGB3.

BIOCHEM BIOPH RES CO.

2016 Sep 2;477(4):768-73.

(IF 2.985)

585. Tan Z, Luo M, Yang J, Cheng Y, Huang J, Lu C, Song D, Ye M, Dai M, Gonzalez FJ, Liu A, Guo B.

.

Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate:

J Pharm Pharmacol.

2016 Sep;68(9):1203-13.

(IF 2.571)

586. Xu L, Wang YR, Li PC, Feng B.

.

Advanced glycation end products increase lipids accumulation in macrophages through upregulation ofreceptor of advanced glycation end products: increasing uptake, esterification and decreasing efflux of cholesterol.

Lipids Health Dis.

2016 Sep 19;15(1):161.

(IF 2.906)

587. Zhao W, Li A, Feng X, Hou T, Liu K, Liu B, Zhang N .

.

Metformin and resveratrol ameliorate muscle insulin resistance through Preventing

Cell Signal.

2016 Sep;28(9):1401-11.

(IF 3.968)

588. Wang Q, Zhou JL, Wang H, Ju Q, Ding Z, Zhou XL, Ge X, Shi QM, Pan C, Zhang JP, Zhang MR, Yu HM, Xu LC.

.

Inhibition effect of cypermethrin mediated by co-regulators SRC-1 and SMRT in interleukin-6-inducedandrogen receptor activation.

Chemosphere.

2016 Sep;158:24-9.

(IF 5.778)

589. Chai J, Luo L, Hou F, Fan X, Yu J, Ma W, Tang W, Yang X, Zhu J, Kang W, Yan J, Liang H .

.

Agmatine Reduces Lipopolysaccharide-Mediated Oxidant Response via Activating PI3K/Akt Pathway and Up-Regulating Nrf2 and HO-1 Expression in Macrophages.

PLoS One.

2016 Sep 29;11(9):e0163634.

(IF 2.74)

590. Chen Y, Cao J, Zhang X.

.

The Role of Cytokine PF4 in the Antiviral Immune Response of Shrimp.

PLoS One.

2016 Sep 15;11(9):e0162954.

(IF 2.74)

591. Wang Z, Zhang H, Sun X, Ren L .

.

The protective role of vitamin D3 in a murine model of asthma via the suppression of TGF-β/Smad signalingand activation of the Nrf2/HO-1 pathway.

Mol Med Rep.

2016 Sep;14(3):2389-96.

(IF 2.1)

592. Liu L, Zhao X, Zou H, Bai R, Yang K, Tian Z .

.

Hypoxia Promotes Gastric Cancer Malignancy Partly through the HIF-1α Dependent

Front Physiol.

2016 Sep 27;7:420.

(IF 3.367)

593. Chen Z, Han S, Huang W, Wu J, Liu Y, Cai S, He Y, Wu S, Song W .

.

MicroRNA-215 suppresses cell proliferation, migration and invasion of colon cancer by repressing Yin-Yang1.

BIOCHEM BIOPH RES CO.

2016 Oct 21;479(3):482-488.

(IF 2.985)

594. Lu H, Zhang L, Gu LL, Hou BY, Du GH .

.

Oxymatrine Induces Liver Injury through JNK Signalling Pathway Mediated by TNF-α In Vivo.

BASIC CLIN PHARMACOL.

2016 Oct;119(4):405-11.

(IF 2.651)

595. Liu F, Luo G, Xiao Q, Chen L, Luo X, Lv J, Chen L .

.

Fucoidan inhibits angiogenesis induced by multiple myeloma cells.

Oncol Rep.

2016 Oct;36(4):1963-72.

(IF 3.417)

596. Xiao F, Zhang P, Chen AH, Wang CY, Zou W, Gu HF, Tang XQ .

.

Hydrogen sulfide inhibits MPP+-induced aldehyde stress and endoplasmic reticulum stress in PC12 cells:involving upregulation of BDNF.

Exp Cell Res.

2016 Oct 15;348(1):106-114.

(IF 3.383)

597. Deng Z, Liu X, Jin J, Xu H, Gao Q, Wang Y, Zhao J .

.

Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53Signaling Pathway Activation.

Int J Biol Sci.

2016 Oct 18;12(11):1298-1308.

(IF 4.858)

598. Zhang X, Wang L, Wang Y, Shi S, Zhu H, Xiao F, Yang J, Yang A, Hao X .

.

Inhibition of FOXQ1 induces apoptosis and suppresses proliferation in prostate cancer cells by controllingBCL11A/MDM2 expression.

Oncol Rep.

2016 Oct;36(4):2349-56.

(IF 3.417)

599. Yan F, Dai G, Zheng X .

.

Mulberry anthocyanin extract ameliorates insulin resistance by regulating PI3K/AKT pathway in HepG2 cellsand db/db mice.

J Nutr Biochem.

2016 Oct;36:68-80.

(IF 4.873)

600. Liang X, Hu Y, Feng S, Zhang S, Zhang Y, Sun C .

.

Heavy chain (LvH) and light chain (LvL) of lipovitellin (Lv) of zebrafish can both bind

Dev Comp Immunol.

2016 Oct;63:47-55.

(IF 3.192)

601. Lu C, Yang L, Chen H, Shan Z.

.

Upregulated long non-coding RNA BC032469 enhances carcinogenesis and metastasis of esophageal squamous cell carcinoma through regulating hTERT expression.

TUMOR BIOL .

2016 Oct 10.[Epub ahead of print].

(IF 3.65)

602. Hua K, Jin J, Zhang H, Zhao B, Wu C, Xu H, Fang L.

.

MicroRNA-7 inhibits proliferation, migration and invasion of thyroid papillary cancer cells via targetingCKS2.

Int J Oncol.

2016 Oct;49(4):1531-1540.

(IF 3.899)

603. Yu H, Shi L, Zhao S, Sun Y, Gao Y, Sun Y, Qi G .

.

Triptolide Attenuates Myocardial Ischemia/Reperfusion Injuries in Rats by Inducing the Activation ofNrf2/HO-1 Defense Pathway.

Cardiovasc Toxicol.

2016 Oct;16(4):325-35.

(IF 2.284)

604. Wang Y, Liu Q, Xu Y, Zhang Y, Lv Y, Tan Y, Jiang N, Cao G, Ma X, Wang J, Cao Z, Yu B, Kou J .

.

Ginsenoside Rg1 Protects against Oxidative Stress-induced Neuronal Apoptosis through Myosin IIA-actinRelated Cytoskeletal Reorganization.

Int J Biol Sci.

2016 Oct 25;12(11):1341-1356.

(IF 4.858)

605. Teng H, Wang P, Xue Y, Liu X, Ma J, Cai H, Xi Z, Li Z, Liu Y.

.

Role of HCP5-miR-139-RUNX1 Feedback Loop in Regulating Malignant Behavior of Glioma Cells.

Mol Ther.

2016 Oct;24(10):1806-1822.

(IF 8.986)

606. Chen Z, Tang J, Cai X, Huang Y, Gao Q, Liang L, Tian L, Yang Y, Zheng Y, Hu Y, Tang N .

.

HBx mutations promote hepatoma cell migration through the Wnt/β-catenin

Cancer Sci.

2016 Oct;107(10):1380-1389.

(IF 4.966)

607. Zhang J, Xia J, Zhang Y, Xiao F, Wang J, Gao H, Liu Y, Rong S, Yao Y, Xu G, Li J .

.

HMGB1-TLR4 signaling participates in renal ischemia reperfusion injury and could be

Am J Transl Res.

2016 Oct 15;8(10):4054-4067.

(IF 3.375)

608. Hu L, Han J, Yang X, Wang Y, Pan H, Xu L .

.

Apoptosis repressor with caspase recruitment domain enhances survival and promotes osteogenic differentiation of human osteoblast cells under Zoledronate treatment.

Mol Med Rep.

2016 Oct;14(4):3535-42.

(IF 2.1)

609. Xu P, Wu Z, Xi Y, Wang L .

.

Epigenetic regulation of placental glucose transporters mediates maternal cadmium-induced fetal growth restriction.

Toxicology.

2016 Oct 27. pii: S0300-483X(16)30255-4.

(IF 4.099)

610. Fu Y, Miao Y, Zheng S, Du J, Liang A .

.

AcMNPV-BmK IT improves the progeny virus production via baculovirus GP64 envelope fusion protein.

Biotechnol Lett.

2016 Oct;38(10):1673-81.

(IF 1.977)

611. Wu C, Luo J .

.

Long Non-Coding RNA (lncRNA) Urothelial Carcinoma-Associated 1 (UCA1) Enhances TamoxifenResistance in Breast Cancer Cells via Inhibiting mTOR Signaling Pathway.

MED SCI MONITOR.

2016 Oct 21;22:3860-3867.

(IF 1.918)

612. Sun X, Zuo H, Liu C, Yang Y.

.

Overexpression of miR-200a protects cardiomyocytes against hypoxia-induced apoptosis by modulating thekelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 signaling axis.

Int J Mol Med.

2016 Oct;38(4):1303-11.

(IF 3.098)

613. Wang XD, Li F, Ma DB, Deng X, Zhang H, Gao J, Hao L, Liu DD, Wang J.

.

Periostin mediates cigarette smoke extract-induced proliferation and migration in pulmonary arterialsmooth muscle cells.

Biomed Pharmacother.

2016 Oct;83:514-520.

(IF 4.545)

614. Wu K, Gao X, Shi B, Chen S, Zhou X, Li Z, Gan Y, Cui L, Kang JX, Li W, Huang R.

.

Enriched endogenous n-3 polyunsaturated fatty acids alleviate cognitive and behavioral

Neuroscience.

2016 Oct 1;333:345-55.

(IF 3.056)

615. Dai H, Chen H, Liu W, You Y, Tan J, Yang A, Lai X, Bie P .

.

Effects of Raf kinase inhibitor protein expression on pancreatic cancer cell growth and motility: an in vivoand in vitro study.

J CANCER RES CLIN.

2016 Oct;142(10):2107-17.

(IF 3.656)

616. Zhou J, Zhu J, Jiang L, Zhang B, Zhu D, Wu Y .

.

Interleukin 18 promotes myofibroblast activation of valvular interstitial cells.

Int J Cardiol.

2016 Oct 15;221:998-1003.

(IF 3.229)

617. Liu S, Xu J, Fang C, Shi C, Zhang X, Yu B, Yin Y .

.

Over-expression of heat shock protein 70 protects mice against lung ischemia/reperfusion injury through SIRT1/AMPK/eNOS pathway.

Am J Transl Res.

2016 Oct 15;8(10):4394-4404.

(IF 3.375)

618. Jiang J, Dong L, Wang L, Wang L, Zhang J, Chen F, Zhang X, Huang M, Li S, Ma W, Xu Q, Huang C, Fang J, Wang C .

.

HER2-targeted antibody drug conjugates for ovarian cancer therapy.

Eur J Pharm Sci.

2016 Oct 10;93:274-86.

(IF 3.616)

619. Li G, Wu X, Yang L, He Y, Liu Y, Jin X, Yuan H.

.

[Corrigendum] TLR4-mediated NF-κB signaling pathway mediates HMGB1-induced pancreatic injury in micewith severe acute pancreatitis.

Int J Mol Med.

2016 Oct;38(4):1313.

(IF 3.098)

620. Chen D, Xia D, , Pan Z, Xu D, Zhou Y, Wu Y, Cai N, Tang Q, Wang C, Yan M, Zhang JJ, Zhou K, Wang Q, Feng Y, Wang X, Xu H, Zhang X, , Tian N.

.

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates discdegeneration in vivo.

Cell Death Dis.

2016 Oct 27;7(10):e2441.

(IF 6.304)

621. Dong M, Jiao G, Liu H, Wu W, Li S, Wang Q, Xu D, Li X, Liu H, Chen Y .

.

Biological Silicon Stimulates Collagen Type 1 and Osteocalcin Synthesis in Human Osteoblast-Like CellsThrough the BMP-2/Smad/RUNX2 Signaling Pathway.

Biol Trace Elem Res.

2016 Oct;173(2):306-15.

(IF 2.639)

622. Li Y, Pan K, Chen L, Ning JL, Li X, Yang T, Terrando N, Gu J, Tao G .

.

Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperativecognitive dysfunction.

J NEUROINFLAMM.

2016 Oct 12;13(1):268.

(IF 5.793)

623. Liu Z, Gan L, Wu T, Feng F, Luo D, Gu H, Liu S, Sun C .

.

Adiponectin reduces ER stress-induced apoptosis through PPARα transcriptional regulation

Cell Death Dis.

2016 Nov 24;7(11):e2487.

(IF 6.304)

624. Li J, Chen Z, Zhou X, Shi S, Qi H, Baker PN, Zhang H .

.

Imbalance between proliferation and apoptosis-related impaired GPR30 expression is involved inpreeclampsia.

Cell Tissue Res.

2016 Nov;366(2):499-508.

(IF 4.044)

625. Chen P, He D, Zhang Y, Yang S, Chen L, Wang S, Zou H, Liao Z, Zhang X, Wu M .

.

Sargassum fusiforme polysaccharides activate antioxidant defense by promoting Nrf2-dependentcytoprotection and ameliorate stress insult during aging.

Food Funct.

2016 Nov 9;7(11):4576-4588.

(IF 4.171)

626. Ye L, Lin ST, Mi YS, Liu Y, Ma Y, Sun HM, Peng ZH, Fan JW .

.

Overexpression of LARP1 predicts poor prognosis of colorectal cancer and is expected to be a potentialtherapeutic target.

TUMOR BIOL .

2016 Nov;37(11):14585-14594.

(IF 3.65)

627. Zheng L, Zhai Y, Li N, Ma F, Zhu H, Du X, Li G, Hua J.

.

The Modification of Tet1 in Male Germline Stem Cells and Interact with PCNA, HDAC1 to promote their Self-renewal and Proliferation.

SCI REP-UK.

2016 Nov 18;6:37414.

(IF 3.998)

628. Wang Y, Zhang S, Xu Y, Zhang Y, Guan H, Li X, Li Y, Wang Y.

.

Upregulation of miR-192 inhibits cell growth and invasion and induces cell apoptosis by targeting TCF7 inhuman osteosarcoma.

TUMOR BIOL .

2016 Nov;37(11):15211-15220.

(IF 3.65)

629. Kuang X, Wei C, Zhang T, Yang Z, Chi J, Wang L.

.

miR-378 inhibits cell growth and enhances apoptosis in human myelodysplastic syndromes.

Int J Oncol.

2016 Nov;49(5):1921-1930.

(IF 3.899)

630. Wang YJ, Liu JZ, Lv P, Dang Y, Gao JY, Wang Y .

.

Long non-coding RNA CCAT2 promotes gastric cancer proliferation and invasion by regulating the E-cadherin and LATS2.

Am J Cancer Res.

2016 Nov 1;6(11):2651-2660.

(IF 5.177)

631. Qiu G, Wang P, Li G, Shi Z, Weir MD, Sun J, Song Y, Wang J, Xu HH, Zhao L.

.

Minipig-BMSCs Combined with a Self-Setting Calcium Phosphate Paste for Bone Tissue Engineering.

Mol Biotechnol.

2016 Nov;58(11):748-756.

(IF 2.022)

632. Que L, He L, Yu C, Yin W, Ma L, Cao B, Yu S .

.

Activation of Nrf2-ARE signaling mitigates cyclophosphamide-induced myelosuppression.

Toxicol Lett.

2016 Nov 16;262:17-26.

(IF 3.569)

633. Chen J, Zhang X, Cai H, Chen Z, Wang T, Jia L, Wang J, Wan Q, Pei X .

.

Osteogenic activity and antibacterial effect of zinc oxide/carboxylated graphene oxide nanocomposites:Preparation and in vitro evaluation.

COLLOID SURFACE B.

2016 Nov 1;147:397-407.

(IF 4.389)

634. Chen T, Ma Z, Zhu L, Jiang W, Wei T, Zhou R, Luo F, Zhang K, Fu Q, Ma C, Yan T.

.

Suppressing Receptor-Interacting Protein 140:a New Sight for Salidroside to Treat Cerebral Ischemia.

Mol Neurobiol.

2016 Nov;53(9):6240-6250.

(IF 4.5)

635. Yang Y, Ren J, Tong Y, Hu X, Lv Q, Tong N.

.

Protective Role of PPARdelta in Lipoapoptosis of Pancreatic β Cells.

Lipids.

2016 Nov;51(11):1259-1268.

(IF 1.919)

636. Li Y, Shi X, Li J, Zhang M, Yu B .

.

Knockdown of KLF11 attenuates hypoxia/reoxygenation injury via JAK2/STAT3 signaling in H9c2.

Apoptosis.

2016 Nov 15. [Epub ahead of print]

(IF 4.543)

637. Yang X, Huo H, Xiu C, Song M, Han Y, Li Y, Zhu Y .

.

Inhibition of osteoblast differentiation by aluminum trichloride exposure is associated with inhibition ofBMP-2/Smad pathway component expression.

Food Chem Toxicol.

2016 Nov;97:120-126.

(IF 4.679)

638. Dong H, Yang S, Zhao Q, Han H, Zhu S, Zhu X, Li C, Wang Z, Xia W, Men Q, Yang L, Huang B.

.

Molecular characterization and protective efficacy of silent information regulator 2A from Eimeria tenella.

PARASITE VECTOR.

2016 Nov 25;9(1):602.

(IF 2.824)

639. Hu Y, Niu X, Wang G, Huang J, Liu M, Peng B.

.

Chronic prostatitis/chronic pelvic pain syndrome impairs erectile function through increased endothelialdysfunction, oxidative stress, apoptosis, and corporal fibrosis in a rat model.

Andrology.

2016 Nov;4(6):1209-1216.

(IF 3.106)

640. Lianmei Zhao, Taotao Han, Yanshuang Li, Jiazeng Sun, Shang Zhang, Yanxin Liu, Baoen Shan, Dexian Zheng, Juan Shi.

.

The lncRNA SNHG5/miR-32 axis regulates gastric cancer cell proliferation and migration by targeting KLF4.

FASEB J.

21 Nov 2016.

(IF 4.966)

641. Wang Y, He T, Liu J, Liu H, Zhou L, Hao W, Sun Y, Wang X .

.

Synergistic effects of overexpression of BMP-2 and TGF-β3 on osteogenic differentiation

Mol Med Rep.

2016 Dec;14(6):5514-5520.

(IF 2.1)

642. Wu Y, Gu C, Huang X.

.

Sevoflurane protects against hepatic ischemia/reperfusion injury by modulating microRNA-200c regulationin mice.

Biomed Pharmacother.

2016 Dec;84:1126-1136.

(IF 4.545)

643. Liu D, Li Y, Luo G, Xiao X, Tao D, Wu X, Wang M, Huang C, Wang L, Zeng F, Jiang G .

.

LncRNA SPRY4-IT1 sponges miR-101-3p to promote proliferation and metastasis of bladder cancer cellsthrough up-regulating EZH2.

Cancer Lett.

2016 Dec 18;388:281-291.

(IF 7.36)

644. Wang L, Zhang S, Cheng H, Lv H, Cheng G, Ci X.

.

Nrf2-mediated liver protection by esculentoside A against acetaminophen toxicity through theAMPK/Akt/GSK3β pathway.

FREE RADICAL BIO MED.

2016 Dec;101:401-412.

(IF 6.17)

645. Liu CY, Hao YN, Yin F, Zhang YL, Liu JH .

.

Geniposide accelerates proteasome degradation of Txnip to inhibit insulin secretion in pancreatic β-cells.

J Endocrinol Invest.

2016 Dec 20. doi: 10.1007/s40618-016-0591-9. [Epub ahead of print]

(IF 3.397)

646. Chen L, Cheng L, Wei X, Yuan Z, Wu Y, Wang S, Ren Z, Liu X, Liu H.

.

Tetramethylpyrazine Analogue CXC195 Protects Against Dopaminergic Neuronal Apoptosis via Activation ofPI3K/Akt/GSK3β Signaling Pathway in 6-OHDA-Induced Parkinson's Disease Mice.

Neurochem Res.

2016 Dec 22.doi: 10.1007/s11064-016-2148-x. [Epub ahead of print]

(IF 3.038)

647. Wu J, Hu G, Dong Y, Ma R, Yu Z, Jiang S, Han Y, Yu K, Zhang S.

.

Matrine induces Akt/mTOR signalling inhibition-mediated autophagy and apoptosis in acute myeloidleukaemia cells.

J Cell Mol Med.

2016 Dec 27. doi: 10.1111/jcmm.13049. [Epub ahead of print]

(IF 4.486)

648. Zhang X, Liu S, Zhang G, Zhong M, Liu T, Wei M, Wu D, Huang X, Cheng Y, Wu Q, Hu S .

.

Bariatric Surgery Ameliorates Diabetic Cardiac Dysfunction by Inhibiting ER Stress in a Diabetic

Obes Surg.

2016 Dec 15. [Epub ahead of print]

(IF 3.412)

649. Han Y, Yang X, Zhao N, Peng J, Gao H, Qiu X.

.

Alpinumisoflavone induces apoptosis in esophageal squamous cell carcinoma by modulating miR-370/PIM1signaling.

Am J Cancer Res.

2016 Dec 1;6(12):2755-2771.

(IF 5.177)

650. Huang T, Yin L, Wu J, Gu JJ, Wu JZ, Chen D, Yu HL, Ding K, Zhang N, Du MY, Qian LX, Lu ZW, He X.

.

MicroRNA-19b-3p regulates nasopharyngeal carcinoma radiosensitivity by targeting TNFAIP3/NF-κB axis.

J EXP CLIN CANC RES.

2016 Dec 5;35(1):188.

(IF 7.068)

651. Yang K, , Lu Y, Xie F, Zou H, Fan X, Li B, Li W, Zhang W, Mei L, Feng SS, Yin Y, Liu Y, Zhang H, Yin C, Zhong Y, Gao J.

.

Cationic liposomes induce cell necrosis through lysosomal dysfunction and late-stage autophagic fluxinhibition.

NANOMEDICINE-UK.

2016 Dec;11(23):3117-3137.

(IF 4.3)

652. Jiang X, Yang Y, Zhou J, Zhu L, Gu Y, Zhang X, Li X, Fang W .

.

Roles of the Putative Type IV-like Secretion System Key Component VirD4 and PrsA in

FRONT CELL INFECT MI.

2016 Dec 2;6:172.

(IF 4.123)

653. Ma C, Long H .

.

Protective effect of betulin on cognitive decline in streptozotocin (STZ)-induced diabetic rats.

Neurotoxicology.

2016 Dec;57:104-111.

(IF 3.105)

654. Shang P, Liu W, Liu T, Zhang Y, Mu F, Zhu Z, Liang L, Zhai X, Ding Y, Li Y, Wen A .

.

Acetyl-11-Keto-β-Boswellic Acid Attenuates Prooxidant and Profibrotic Mechanisms Involving TransformingGrowth Factor-β1, and Improves Vascular Remodeling in Spontaneously

SCI REP-UK.

2016 Dec 23;6:39809.

(IF 3.998)

655. Yang M, Zhang F, Qin K, Wu M, Li H, Zhu H, Ning Q, Lei P, Shen G.

.

Glucose-Regulated Protein 78-Induced Myeloid Antigen-Presenting Cells Maintained Tolerogenic Signatureupon LPS Stimulation.

Front Immunol.

2016 Dec 1;7:552.

(IF 5.085)

656. Song H, Li L, Zhong L, Yang R, Jiang K, Yang X, Liu B.

.

NLS-RARα modulates acute promyelocytic leukemia NB4 cell proliferation and differentiation

Mol Med Rep.

2016 Dec;14(6):5495-5500.

(IF 2.1)

657. Su W, Mo Y, Wu F, Guo K, Li J, Luo Y, Ye H, Guo H, Li D, Yang Z.

.

miR-135b reverses chemoresistance of non-small cell lung cancer cells by downregulation of FZD1.

Biomed Pharmacother.

2016 Dec;84:123-129.

(IF 4.545)

658. Zhang Y, Yuan J, Zhang X, Yan F, Huang M, Wang T, Zheng X, Zhang M.

.

Angiomotin promotes the malignant potential of colon cancer cells by activating the YAP-ERK/PI3K-AKTsignaling pathway.

Oncol Rep.

2016 Dec;36(6):3619-3626.

(IF 3.417)

659. Wu K, Guo C, Lu X, Wu X, Pan H, Su M .

.

Impact of perinatal exposure to acetaminophen on hepatocellular metabolic function in offspring.

Am J Transl Res.

2016 Dec 15;8(12):5646-5652.

(IF 3.375)

660. Ye T, Su J, Huang C, Yu D, Dai S, Huang X, Chen B, Zhou M.

.

Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion

ONCOTARGETS THER.

2016 Dec 12;9:7481-7492.

(IF 3.337)

661. Chen J, Yang F, Yu X, Yu Y, Gong Y.

.

Cyclosporine A promotes cell proliferation, collagen and α-smooth muscle actin expressions in

J Periodontal Res.

2016 Dec;51(6):735-747.

(IF 2.926)

662. Pan X, Wang H, Tong D, Wang C, Sun L, Zhao C, Li Y, Zhu L, Wu D.

.

Physcion induces apoptosis in hepatocellular carcinoma by modulating miR-370.

Am J Cancer Res.

2016 Dec 1;6(12):2919-2931.

(IF 5.177)

663. Wu Y, Dong L, Bao S, Wang M, Yun Y, Zhu R.

.

FK228 augmented temozolomide sensitivity in human glioma cells by blocking PI3K/AKT/mTOR signalpathways.

Biomed Pharmacother.

2016 Dec;84:462-469.

(IF 4.545)

664. Ji X, Xu B, Yao M, Mao Z, Zhang Y, Xu G, Tang Q, Wang X, Xia Y.

.

Graphene oxide quantum dots disrupt autophagic flux by inhibiting lysosome activity in GC-2 and TM4 celllines.

Toxicology.

2016 Dec 30;374:10-17.

(IF 4.099)

665. Dai C, Ciccotosto GD, Cappai R, Tang S, Li D, Xie S, Xiao X, Velkov T .

.

Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity,Suppression of Oxidative Stress, and Apoptosis.

Mol Neurobiol.

2016 Dec 12.[Epub ahead of print]

(IF 4.5)

666. Wang H, Chen L, Zhang L, Gao X, Wang Y, Weiwei T.

.

Protective effect of Sophoraflavanone G on streptozotocin (STZ)-induced inflammation in diabetic rats.

Biomed Pharmacother.

2016 Dec;84:1617-1622.

(IF 4.545)

667. Liu Y, Feng X, Zhang Y, Jiang H, Cai X, Yan X, Huang Z, Mo F, Yang W, Yang C, Yang S, Liu X .

.

Establishment and characterization of a novel osteosarcoma cell line: CHOS.

J Orthop Res.

2016 Dec;34(12):2116-2125.

(IF 2.728)

668. You D, Wang MM, Ye BC .

.

Acetyl-CoA synthetases of Saccharopolyspora erythraea are regulated by the nitrogen response regulatorGlnR at both transcriptional and post-translational levels.

Mol Microbiol.

2016 Dec 17.doi: 10.1111/mmi.13595. [Epub ahead of print]

(IF 3.418)

669. Yuan F, Bai G, Miao Y, Chen Y, Li X, Chen J.

.

Annosquacin B induces mitochondrial apoptosis in multidrug resistant human breast cancer cell line MCF-7/ADR through selectively modulating MAPKs pathways.

Pharm Biol.

2016 Dec;54(12):3040-3045.

(IF 2.971)

670. Huang Y, Huang D, Weng J, Zhang S, Zhang Q, Mai Z, Gu W .

.

Effect of reversine on cell cycle, apoptosis, and activation of hepatic stellate cells.

Mol Cell Biochem.

2016 Dec;423(1-2):9-20.

(IF 2.795)

671. Liu G, Xiang T, Wu QF, Wang WX.

.

Curcumin suppresses the proliferation of gastric cancer cells by downregulating H19.

Oncol Lett.

2016 Dec;12(6):5156-5162.

(IF 2.311)

672. Liang Z, Nie H, Xu Y, Peng J, Zeng Y, Wei Y, Wen X, Qiu J, Zhong W, Deng X, He J .

.

Therapeutic effects of rosmarinic acid on airway responses in a murine model of asthma.

Int Immunopharmacol.

2016 Dec;41:90-97.

(IF 3.943)

673. Liu Q, Lin X, Li H, Yuan J, Peng Y, Dong L, Dai S.

.

Paeoniflorin ameliorates renal function in cyclophosphamide-induced mice via AMPK suppressedinflammation and apoptosis.

Biomed Pharmacother.

2016 Dec;84:1899-1905.

(IF 4.545)

674. Li H, Jiao Y, Zhang L, Wang C, Zhang X, Guo H, Xu H .

.

The interferon-inducible protein p205 acts as an activator in osteoblast differentiation of

Differentiation.

2016 Dec;92(5):318-325.

(IF 2.392)

675. Zhi-Peng Wang, Shu-Yuan Chen, Ye Tian.

.

Wild-type p53-induced phosphatase 1 is a prognostic marker and therapeutic target in bladder transitional cell carcinoma.

Oncology Letters.

December 8, 2016.

(IF 1.871)

676. Jiao S, Zhu H, He P, Teng J .

.

Betulinic acid protects against cerebral ischemia/reperfusion injury by activating the PI3K/Akt signaling pathway.

Biomed Pharmacother.

2016 Dec;84:1533-1537.

(IF 4.545)

677. Liu Z, Gu H, Gan L, Xu Y, Feng F, Saeed M, Sun C .

.

Reducing Smad3/ATF4 was essential for Sirt1 inhibiting ER stress-induced apoptosis in mice brownadipose tissue.

ONCOTARGET.

2016 Dec 20. doi: 10.18632/oncotarget.14035. [Epub ahead of print]

(IF 5.168)

678. Wang Y, Chen B, Wang Z, Zhang W, Hao K, Chen Y, Li K, Wang T, Xie Y, Huang Z, Tong X.

.

Marsdenia tenacissimae extraction (MTE) inhibits the proliferation and induces the apoptosis of humanacute T cell leukemia cells through inactivating PI3K/AKT/mTOR signaling pathway via PTEN enhancement.

ONCOTARGET.

2016 Dec 13;7(50):82851-82863.

(IF 5.168)

679. Zhou R, Luo F, Lei H, Zhang K, Liu J, He H, Gao J, Chang X, He L, Ji H, Yan T, Chen T .

.

Liujunzi Tang, a famous traditional Chinese medicine, ameliorates cigarette smoke-induced

J Ethnopharmacol.

2016 Dec 4;193:643-651.

(IF 3.69)

680. Wei LN, Zhu LW, Tang YJ .

.

Succinate production positively correlates with the affinity of the global transcription

Biotechnol Biofuels.

2016 Dec 8;9:264.

(IF 4.815)

681. Zhao L, Feng Y, Hu H, Shi A, Zhang L, Wan M.

.

Low-Intensity Pulsed Ultrasound Enhances Nerve Growth Factor-Induced Neurite Outgrowth through Mechanotransduction-Mediated ERK1/2-CREB-Trx-1 Signaling.

Ultrasound Med Biol.

2016 Dec;42(12):2914-2925.

(IF 2.514)

682. Danfeng Xu, Di Lian, Jing Wu, Ying Liu, Mingjie Zhu, Jiaming Sun, Dake He, Ling Li.

.

Brain-derived neurotrophic factor reduces inflammation and hippocampal apoptosis in experimental Streptococcus pneumoniae meningitis.

Journal of Neuroinflammation.

2017 14:156.

(IF 5.7)

683. Yu Ma, Yi Zhao, Ran Zhang, Xiaoxia Liang, Zhongqiong Yin, Yi Geng, Gang Shu, Xu Song, Yuanfeng Zou, Lixia Li, Lizi Yin, Guizhou Yue, Yinglun Li, Gang Ye, Changliang He.

.

α-Cyperone Inhibits PMA-Induced EPCR Shedding through PKC Pathway.

BIOL PHARM BULL.

2017, 1678-1685.

(IF 1.863)

684. Huang Jie, Guo Li.

.

Knockdown of SOX9 Inhibits the Proliferation, Invasion, and EMT in Thyroid Cancer Cells.

Oncology Research Featuring Preclinical & Clinical CancerTherapeutics.

2017, pp. 167-176(10).

685. Sitong Cui, Liang Liu, Teng Wan, Lei Jiang, Yan Shi, Liangsheng Luo.

.

MiR-520b inhibits the development of glioma by directly targeting MBD2.

Am J Cancer Res.

2017; 7(7): 1528–1539.

(IF 5.177)

686. Zhiwang Song, Chan Feng, Yonglin Lu, Yong Gao, Yun Lin, Chunyan Dong.

.

Overexpression and biological function of MEF2D in human pancreatic cancer.

Am J Transl Res.

2017; 9(11): 4836–4847.

(IF 3.375)

687. Wang H, Xie Z, Hou T, Li Z, Huang K, Gong J, Zhou W, Tang K, Xu J, Dong S.

.

MiR-125b Regulates the Osteogenic Differentiation of Human Mesenchymal Stem Cells by Targeting BMPR1b.

CELL PHYSIOL BIOCHEM.

2017;41(2):530-542.

(IF 5.5)

688. Yu Li, Shengnan He, Jishun Tang, Nana Ding, Xiaoyan Chu, Lianping Cheng, Xuedong Ding, Ting Liang, Shibin Feng, Sajid Ur Rahman, Xichun Wang, Jinjie Wu.

.

Andrographolide Inhibits Inflammatory Cytokines Secretion in LPS-Stimulated RAW264.7 Cells through Suppression of NF-κB/MAPK Signaling Pathway.

Evidence-Based Complementary and Alternative Medicine.

2017, Article ID 8248142, 9 pages.

(IF 1.984)

689. Lei Xie, Sifei Yu, Zhenfei Wang, Kai Yang, Zhuochao Liu, Changwei Li, Yu Liang.

.

Nicotinamide Adenine Dinucleotide Protects against Spinal Cord Ischemia Reperfusion Injury-Induced Apoptosis by Blocking Autophagy.

Oxidative Medicine and Cellular Longevity.

Volume 2017, Article ID 7063874, 10 pages.

(IF 4.868)

690. Jingfeng Wang, Zhiming Li, Yanyan Wang, Jingjing Zhang, Weipeng Zhao, Mingqiang Fu, Xueting Han, Jingmin Zhou, and Junbo Ge.

.

Qiliqiangxin Enhances Cardiac Glucose Metabolism and Improves Diastolic Function in Spontaneously Hypertensive Rats.

Evidence-Based Complementary and Alternative Medicine.

Volume 2017, Article ID 3197320, 11 pages.

(IF 1.984)

691. Xiao Q, Qu Z, Zhao Y, Yang L, Gao P.

.

Orientin Ameliorates LPS-Induced Inflammatory Responses through the Inhibitory of the NF-κB Pathway and NLRP3 Inflammasome.

EVID-BASED COMPL ALT.

2017;2017:2495496.

(IF 1.813)

692. Xie L, Yu S, Yang K, Li C, Liang Y.

.

Hydrogen Sulfide Inhibits Autophagic Neuronal Cell Death by Reducing Oxidative Stress in Spinal Cord Ischemia Reperfusion Injury.

Oxid Med Cell Longev.

2017;2017:8640284.

(IF 5.076)

693. Nan Wang, Yong Li, Jianhong Zhou.

.

miR-31 Functions as an Oncomir Which Promotes Epithelial-Mesenchymal Transition via Regulating BAP1 in Cervical Cancer.

BioMed Research International.

Volume 2017, Article ID 6361420, 12 pages.

(IF 2.197)

694. M Guo, X Zhao, X Yuan, P Li.

.

Elevated microRNA-34a contributes to trophoblast cell apoptosis in preeclampsia by targeting BCL-2.

Journal of Human Hypertension.

31, pages 815–820 (2017).

(IF 1.935)

695. Dehua Zhou, Zhou Li, Xuefeng Bai.

.

BRAFV600E and RET/PTC Promote Proliferation and Migration of Papillary Thyroid Carcinoma Cells In Vitro by Regulating Nuclear Factor-κB.

MED SCI MONITOR.

2017; 23: 5321–5329.

(IF 1.918)

696. Yong Zhou, Chuandong Yang, Kunpeng Wang, Xuefeng Liu, Quan Liu.

.

MicroRNA-33b Inhibits the Proliferation and Migration of Osteosarcoma Cells via Targeting Hypoxia-Inducible Factor-1α.

Oncology Research Featuring Preclinical & Clinical CancerTherapeutics.

Volume 25, Number 3, 2017, pp. 397-405(9).

697. Zhu Z, Huang F, Wang F, Zhang Y, Zhao X, Wang W.

.

Morinda Officinalis Polysaccharides Stimulate Hypothalamic GnRH Secretion in Varicocele Progression.

EVID-BASED COMPL ALT.

2017;2017:9057959.

(IF 1.813)

698. Rui Xie, Hong Zhang, Xing-zhou Wang, Xiao-zhong Yang, Shang-nong Wu, Hong-gang Wang, Peng Shen, Tian-heng Ma.

.

The protective effect of betulinic acid (BA) diabetic nephropathy on streptozotocin (STZ)-induced diabetic rats.

Food & Function.

2017, 8, 299-306.

(IF 3.241)

699. Yandong Nan, Ruijing Chang, Hua Jiang, Shuanying Yang, Faguang Jin, Yonghong Xie.

.

Downregulation of P38 phosphorylation correlates with low-grade differentiation and proliferation of lung squamous cell carcinoma.

Am J Transl Res.

2017; 9(4): 1922–1933.

(IF 3.375)

700. Peng Chen, Shibo Duan, Xia Zheng.

.

HOTTIP/HOXA13 axis is positively associated with cell proliferation in glioma.

Int J Clin Exp Med.

2017;10(12):16388-16394.

(IF 0.166)

701. Hai-Jing Sun, Yan Lu, Hao-Wei Wang, Hao Zhang, Shuang-Ran Wang, Wen-Yun Xu, Hai-Long Fu, Xue-Ya Yao, Feng Yang, Hong-Bin Yuan.

.

Activation of Endocannabinoid Receptor 2 as a Mechanism of Propofol Pretreatment-Induced Cardioprotection against Ischemia-Reperfusion Injury in Rats.

Oxidative Medicine and Cellular Longevity.

Volume 2017, Article ID 2186383, 18 pages.

(IF 4.868)

702. Chu-yi Guo, Mu-xue Yu, Jie-min Dai, Si-nian Pan, Zhen-tong Lu, Xiao-shan Qiu, Si-qi Zhuang.

.

Roles of Mitogen-Activating Protein Kinase Kinase Kinase Kinase-3 (MAP4K3) in Preterm Skeletal Muscle Satellite Cell Myogenesis and Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation Regulation.

MED SCI MONITOR.

2017; 23: 3562–3570.

(IF 1.918)

703. Dengfeng Li, Jiashu Hu, Hongming Song, Hui Xu, Chengyang Wu, Bingkun Zhao, Dan Xie, Tianqi Wu, Junyong Zhao, Lin Fang.

.

miR-143-3p targeting LIM domain kinase 1 suppresses the progression of triple-negative breast cancer cells.

Am J Transl Res.

2017; 9(5): 2276–2285.

(IF 3.375)

704. Lu-Lu Wang, Zheng-Sen Chen, Wen-Di Zhou, Jin Shu, Xiao-Hua Wang, Rui Jin, Li-Li Zhuang, Mir Alireza Hoda, Hao Zhang, Guo-Ping Zhou.

.

Down-regulated GATA-1 up-regulates interferon regulatory factor 3 in lung adenocarcinoma.

Scientific Reports.

7, Article number: 2551 (2017).

(IF 4.011)

705. Xiaoyu Li, Xiaojiaoyang Li, Junxian Lu, Youyi Huang, Lili Lv, Yongfu Luan, Runping Liu, Rong Sun.

.

Saikosaponins induced hepatotoxicity in mice via lipid metabolism dysregulation and oxidative stress: a proteomic study.

BMC Complementary and Alternative Medicine.

2017 17:219.

(IF 2.479)

706. Huiming Hu, Qiaoqiao Zhu, Jie Su, Yajun Wu, Yanchen Zhu, Yin Wang, Hui Fang, Minxia Pang, Bo Li, Suhong Chen, Guiyuan Lv.

.

Effects of an Enriched Extract of Paeoniflorin, a Monoterpene Glycoside used in Chinese Herbal Medicine, on Cholesterol Metabolism in a Hyperlipidemic Rat Model.

MED SCI MONITOR.

2017; 23: 3412–3427.

(IF 1.918)

707. Dengfeng Li, Hongming Song, Tianqi Wu, Dan Xie, Jiashu Hu, Junyong Zhao, Lin Fang.

.

MiR-138-5p targeting LIMK1 suppresses breast cancer cell proliferation and motility.

J ROY SOC MED.

2017, 7, 52030-52038.

(IF 5.238)

708. Saisai Wang, Fei Wang, Qiang Zhang, Yiyun Cheng.

.

A core–shell structured polyplex for efficient and non-toxic gene delivery.

Journal of Materials Chemistry B.

26, 2017.

(IF 5.047)

709. Wang M, Li Y, Ni C, Song G.

.

Honokiol Attenuates Oligomeric Amyloid β1-42-Induced Alzheimer's Disease in Mice Through Attenuating Mitochondrial Apoptosis and Inhibiting the Nuclear Factor Kappa-B Signaling Pathway.

CELL PHYSIOL BIOCHEM.

2017;43(1):69-81.

(IF 5.5)

710. Wenjuan Cao, Junqiang Tian, Chong Li, Yanjun Gao, Xingchen Liu, Jianzhong Lu, Yuhan Wang, Zhiping Wang, Robert S. Svatek, Ronald Rodriguez.

.

A novel bladder cancer - specific oncolytic adenovirus by CD46 and its effect combined with cisplatin against cancer cells of CAR negative expression.

Virology Journal.

2017 14:149.

(IF 2.464)

711. Yun Xiao, Xiaoyu Wang, Ben Wang, Xueyao Liu, Xurong Xu, Ruikang Tang.

.

Long-term Effect of Biomineralized Insulin Nanoparticles on Type 2 Diabetes Treatment.

Theranostics.

2017; 7(17): 4301–4312.

(IF 8.579)

712. Zi-huan Yin, Xing-wang Jiang, Wu-bing Shi, Qian-le Gui, Dong-feng Yu.

.

Expression and Clinical Significance of ILF2 in Gastric Cancer.

Disease Markers.

Volume 2017, Article ID 4387081, 9 pages.

(IF 2.761)

713. Haiqi Mu, Bo Qiu, Qipeng Xie, Yijun Wang, Cunjin Nan, Wei Han, Tong Zhao, Shan-Chao Zhao.

.

Gelsolin-like actin-capping protein is highly expressed in prostate cancer and affects cell apoptosis, proliferation and migration.

INT J CLIN EXP PATHO.

2017;10(1):377-384.

(IF 0.252)

714. Jiang Tinghui, Li Mengfan, Li Qiuyin, Guo Zhiqiang, Sun Xianjun, Zhang Xufeng, Liu Yan, Yao Wenyi, Xiao Ping.

.

MicroRNA-98-5p Inhibits Cell Proliferation and Induces Cell Apoptosis in Hepatocellular Carcinoma via Targeting IGF2BP1.

Oncology Research Featuring Preclinical & Clinical CancerTherapeutics.

Volume 25, Number 7, 2017, pp. 1117-1127(11).

715. Liu C, He X, Wu X, Wang Z, Zuo W, Hu G.

.

Clinicopathological and prognostic significance of GPx2 protein expression in nasopharyngeal carcinoma.

Cancer Biomarkers.

vol. 19, no. 3, pp. 335-340, 2017.

(IF 2.859)

716. Sun HJ, Chen D, Wang PY, Wan MY, Zhang CX, Zhang ZX, Lin W, Zhang F.

.

Salusin-β Is Involved in Diabetes Mellitus-Induced Endothelial Dysfunction via Degradation of Peroxisome Proliferator-Activated Receptor Gamma.

Oxid Med Cell Longev.

2017;2017:6905217.

(IF 5.076)

717. Guowei Zhang, Hao Zheng, Guojun Zhang, Ruirui Cheng, Chunya Lu, Yijie Guo, Guoqiang Zhao.

.

MicroRNA-338-3p suppresses cell proliferation and induces apoptosis of non-small-cell lung cancer by targeting sphingosine kinase 2.

Cancer Cell International.

2017 17:46.

(IF 3.439)

718. Sun H, Zhuo X, Zhao X, Yang Y, Chen X, Yao C, Du A.

.

The heat shock protein 90 of Toxoplasma gondii is essential for invasion of host cells and tachyzoite growth.

Parasite.

2017;24:22.

(IF 2.05)

719. Zhen-Long Yu, Yu-Lin Peng, Chao Wang, Fei Cao, Xiao-Kui Huo, Xiang-Ge Tian, Lei Feng, Jing Ning, Bao-Jing Zhang, Cheng-Peng Sun, Xiao-Chi Ma.

.

Alismanoid A, an unprecedented 1,2-seco bisabolene from Alisma orientale, and its protective activity against H2O2-induced damage in SH-SY5Y cells

New Journal of Chemistry.

21, 2017.

(IF 3.069)

720. Liyuan Wang, Hongchao Jiao, Jingpeng Zhao, Xiaojuan Wang, Shuhong Sun, Hai Lin.

.

Allicin Alleviates Reticuloendotheliosis Virus-Induced Immunosuppression via ERK/Mitogen-Activated Protein Kinase Pathway in Specific Pathogen-Free Chickens.

Front Immunol.

2017; 8: 1856.

(IF 5.085)

721. Hao Jin, Geliang Xu, Qiang Zhang, Qing Pang, Meifang Fang.

.

Synaptotagmin-7 is overexpressed in hepatocellular carcinoma and regulates hepatocellular carcinoma cell proliferation via Chk1–p53 signaling.

ONCOTARGETS THER.

2017; 10: 4283–4293.

(IF 3.337)

722. Zeng W, Dai H, Yan M, Cai X, Luo H, Ke M, Liu Z.

.

Decitabine-Induced Changes in Human Myelodysplastic Syndrome Cell Line SKM-1 Are Mediated by FOXO3A Activation.

J Immunol Res.

2017;2017:4302320.

(IF 3.327)

723. Ke Liu, Yi Hou, Yunke Liu, Jia Zheng.

.

LncRNA SNHG15 contributes to proliferation, invasion and autophagy in osteosarcoma cells by sponging miR-141.

Journal of Biomedical Science.

2017 24:46.

(IF 5.203)

724. Lu CY, Liu X, Jiang H, Pan F, Ho CS, Ho RC.

.

Effects of Traumatic Stress Induced in the Juvenile Period on the Expression of Gamma-Aminobutyric Acid Receptor Type A Subunits in Adult Rat Brain.

Neural Plast.

2017;2017:5715816.

(IF 3.093)

725. Wang Y, Wang W, Xu H, Sun Y, Sun J, Jiang Y, Yao J, Tian Y.

.

Non-Lethal Sonodynamic Therapy Inhibits Atherosclerotic Plaque Progression in ApoE-/- Mice and Attenuates ox-LDL-mediated Macrophage Impairment by Inducing Heme Oxygenase-1.

CELL PHYSIOL BIOCHEM.

2017, Vol.41, No. 6

(IF 5.5)

726. Gang Chen, Dongdong Wang, Xiongqi Zhao, Jun Cao, Yingpeng Zhao, Fan Wang, Jianhua Bai, Ding Luo, Li Li.

.

miR-155-5p modulates malignant behaviors of hepatocellular carcinoma by directly targeting CTHRC1 and indirectly regulating GSK-3β-involved Wnt/β-catenin signaling.

Cancer Cell International.

2017 17:118.

(IF 3.439)

727. Chen WP, Hu ZN, Jin LB, Wu LD.

.

Licochalcone A Inhibits MMPs and ADAMTSs via the NF-κB and Wnt/β-Catenin Signaling Pathways in Rat Chondrocytes.

CELL PHYSIOL BIOCHEM.

2017;43(3):937-944.

(IF 5.5)

728. Zuhua Chen, Zhentao Liu, Wenwen Huang, Zhongwu Li, Jianling Zou, Jingyuan Wang, Xiaoting Lin, Beifang Li, Dongshao Chen, Yanting Hu, Jiafu Ji, Jing Gao, Lin Shen.

.

Gimatecan exerts potent antitumor activity against gastric cancer in vitro and in vivo via AKT and MAPK signaling pathways.

Journal of Translational Medicine.

2017 15:253.

(IF 4.098)

729. Chunhui Hu, Beibei Chen, Yibin Zhou, Yuxi Shan.

.

High expression of Rab25 contributes to malignant phenotypes and biochemical recurrence in patients with prostate cancer after radical prostatectomy.

Cancer Cell International.

2017 17:45.

(IF 3.439)

730. Tao Jiang, Chun Yang, Liyuan Ma, Zehua Wu, Ling Ye, Xiaoqiang Ma, Hai Li, Junwei Fan, Yinxue Yang.

.

Overexpression of GRK3, Promoting Tumor Proliferation, Is Predictive of Poor Prognosis in Colon Cancer.

Disease Markers.

Volume 2017, Article ID 1202710, 11 pages.

(IF 2.761)

731. Xu Yang, Shimin Pei, Huanan Wang, Yipeng Jin, Fang Yu, Bin Zhou, Hong Zhang, Di Zhang, Degui Lin.

.

Tiamulin inhibits breast cancer growth and pulmonary metastasis by decreasing the activity of CD73.

BMC Cancer.

2017 17:255.

(IF 3.15)

732. Zou J, Zhang Y, Sun J, Wang X, Tu H, Geng S, Liu R, Chen Y, Bi Z.

.

Deoxyelephantopin Induces Reactive Oxygen Species-Mediated Apoptosis and Autophagy in Human Osteosarcoma Cells.

CELL PHYSIOL BIOCHEM.

2017;42(5):1812-1821.

(IF 5.5)

733. Lyu F, Gao F, Wei Q, Liu L.

.

Changes of membrane fatty acids and proteins of Shewanella putrefaciens treated with cinnamon oil and gamma irradiation.

BIORESOURCES.

2017;4(1):10.

(IF 1.409)

734. Jiang W, Huang W, Chen Y, Zou M, Peng D, Chen D.

.

HIV-1 Transactivator Protein Induces ZO-1 and Neprilysin Dysfunction in Brain Endothelial Cells via the Ras Signaling Pathway.

Oxid Med Cell Longev.

2017;2017:3160360.

(IF 5.076)

735. Wu X, Liu D, Gao X, Xie F, Tao D, Xiao X, Wang L, Jiang G, Zeng F.

.

Inhibition of BRD4 Suppresses Cell Proliferation and Induces Apoptosis in Renal Cell Carcinoma.

CELL PHYSIOL BIOCHEM.

2017;41(5):1947-1956.

(IF 5.5)

736. Li Q, Zhang Y, Shi JL, Wang YL, Zhao HB, Shao DY, Huang QS, Yang H, Jin ML.

.

Mechanism and Anticancer Activity of the Metabolites of an Endophytic Fungi from Eucommia ulmoides Oliv.

ANTI-CANCER AGENT ME.

2017;17(7):982-989.

(IF 2.049)

737. Liu X, Pan YJ, Zheng JN, Pei DS.

.

The Role of Tumor Suppressor DLC-1: Far From Clear.

ANTI-CANCER AGENT ME.

2017;17(7):896-901.

(IF 2.049)

738. Ye Y, Yang Y, Chen C, Li Z, Jia Y, Su X, Wang C, He X.

.

Electroacupuncture Improved Hippocampal Neurogenesis following Traumatic Brain Injury in Mice through Inhibition of TLR4 Signaling Pathway.

Stem Cells Int.

2017;2017:5841814.

(IF 3.869)

739. Xu X, Zhu Q, Zhang R, Wang Y, Niu F, Wang W, Sun D, Wang A.

.

ITRAQ-Based Proteomics Analysis of Acute Lung Injury Induced by Oleic Acid in Mice.

CELL PHYSIOL BIOCHEM.

2017;44(5):1949-1964.

(IF 5.5)

740. Chao Quan, Can Wang, Peng Duan, WenTing Huang, Kedi Yang.

.

Prenatal bisphenol a exposure leads to reproductive hazards on male offspring via the Akt/mTOR and mitochondrial apoptosis pathways.

Wiley Periodicals, Inc. Environ Toxicol.

32: 1007–1023, 2017.

741. Zhang D, Lu C, Yu Z, Wang X, Yan L, Zhang J, Li H, Wang J, Wen A.

.

Echinacoside Alleviates UVB Irradiation-Mediated Skin Damage via Inhibition of Oxidative Stress, DNA Damage, and Apoptosis.

Oxid Med Cell Longev.

2017;2017:6851464.

(IF 5.076)

742. Li P, Wei J, Gao X, Wei B, Lin H, Huang R, Niu Y, Lim K, Jing K, Chu J.

.

Insulin Promotes the Proliferation of Human Umbilical Cord Matrix-Derived Mesenchymal Stem Cells by Activating the Akt-Cyclin D1 Axis.

Stem Cells Int.

2017;2017:7371615.

(IF 3.869)

743. Li J, Chen L, Xiong Y, Zheng X, Xie Q, Zhou Q, Shi L, Wu C, Jiang J, Wang H.

.

Knockdown of PD-L1 in Human Gastric Cancer Cells Inhibits Tumor Progression and Improves the Cytotoxic Sensitivity to CIK Therapy.

CELL PHYSIOL BIOCHEM.

2017;41(3):907-920.

(IF 5.5)

744. Binwu Hu, Xiao Lv, Feng Gao, Songfeng Chen, Shangyu Wang, Xiangcheng Qing, Jianxiang Liu, Baichuan Wang, Zengwu Shao.

.

Downregulation of DEPTOR inhibits the proliferation, migration, and survival of osteosarcoma through PI3K/Akt/mTOR pathway.

ONCOTARGETS THER.

2017; 10: 4379–4391.

(IF 3.337)

745. Xinwen Ke, Xing Zeng, Xian Wei, Yuanqing Shen, Jiahua Gan, Huake Tang, Zhiquan Hu.

.

MiR-514a-3p inhibits cell proliferation and epithelial-mesenchymal transition by targeting EGFR in clear cell renal cell carcinoma.

Am J Transl Res.

2017; 9(12): 5332–5346.

(IF 3.375)

746. Liang Liu, Sitong Cui, Rui Zhang, Yan Shi, Liangsheng Luo.

.

MiR-421 inhibits the malignant phenotype in glioma by directly targeting MEF2D.

Am J Cancer Res.

2017; 7(4): 857–868.

(IF 5.177)

747. Yang W, Huang J, Xiao B, Liu Y, Zhu Y, Wang F, Sun S.

.

Taurine Protects Mouse Spermatocytes from Ionizing Radiation-Induced Damage Through Activation of Nrf2/HO-1 Signaling.

CELL PHYSIOL BIOCHEM.

2017;44(4):1629-1639.

(IF 5.5)

748. Chen L, Xiong Y, Li J, Zheng X, Zhou Q, Turner A, Wu C, Lu B, Jiang J.

.

PD-L1 Expression Promotes Epithelial to Mesenchymal Transition in Human Esophageal Cancer.

CELL PHYSIOL BIOCHEM.

2017;42(6):2267-2280.

(IF 5.5)

749. Gong Y, Qin Z, Zhou B, Chen H, Shi Z, Zhang J.

.

MicroRNA-200a Inhibits Transforming Growth Factor β1-Induced Proximal Tubular Epithelial-Mesenchymal Transition by Targeting β-Catenin.

Nephron.

Nephron 2017;137:237-249.

(IF 2.089)

750. Cheng He-Peng, Liu Qian, Li Yang, Li Xiao-Dong, Zhu Chao-Yang.

.

The Inhibitory Effect of PDIA6 Downregulation on Bladder Cancer Cell Proliferation and Invasion.

Oncology Research Featuring Preclinical & Clinical CancerTherapeutics.

2017, pp. 587-593(7).

751. Di Sun, Liting Zhou, Shuyue Wang, Te Liu, Jian Zhu, Yiyang Jia, Jin Xu, Huaiji Chen, Qi Wang, Feng Xu, Yuezhu Zhang, Lin Ye.

.

Effect of Di-(2-ethylhexyl) phthalate on the hypothalamus-pituitary-thyroid axis in adolescent rat.

Endocrine Journal.

Vol. 65 (2017), No. 3.

(IF 1.94)

752. Hu TX, Wang G, Wu W, Gao L, Tan QY, Wang J.

.

Hydrogen Sulfide Inhibits High Glucose-Induced sFlt-1 Production via Decreasing ADAM17 Expression in 3T3-L1 Adipocytes.

Int J Endocrinol.

2017;2017:9501792.

(IF 2.299)

753. Jian-Xia Xu, Wei Xiong, Zhen Zeng, Yi Tang, Ya-Lan Wang, Ming Xiao, Ming Li, Qing Shu Li, Guang-Lin Song, Jing Kuang.

.

Effect of ART1 on the proliferation and migration of mouse colon carcinoma CT26 cells in vivo.

Molecular Medicine Reports.

January 26, 2017.

(IF 1.851)

754. Huili Wang, Zhijiang Chen, Hongen Chang, Xiaoping Mu, Wenyu Deng, Zhaohu Yuan, Fang Yao, Yan Liu, Rongjia Mai, Bingyi Wu.

.

Expression of glia maturation factor γ is associated with colorectal cancer metastasis and its downregulation suppresses colorectal cancer cell migration and invasion in vitro.

Oncology Reports.

January 9, 2017.

(IF 3.041)

755. Lingyan Yang, Wen-Cheng Wang, Shih-Chun Candice Lung, Zhelin Sun, Chongjun Chen, Jen-Kun Chen, Qiang Zou, Yu-Hsin Lin, Chia-Hua Lin.

.

Polycyclic aromatic hydrocarbons are associated with increased risk of chronic obstructive pulmonary disease during haze events in China.

Science of The Total Environment.

Volume 574, 1 January 2017, Pages 1649-1658.

(IF 5.589)

756. Chen Juanni, Li Shili, Luo Jinxiang, Zhang Yongqiang, Ding Wei.

.

Graphene Oxide Induces Toxicity and Alters Energy Metabolism and Gene Expression in Ralstonia solanacearum.

Journal of Nanoscience and Nanotechnology.

January 2017, pp. 186-195(10).

(IF 1.093)

757. Cui L, Bi J, Yan D, Ye X, Zheng M, Yu G, Wan X.

.

JSI-124 inhibits IgE production in an IgE B cell line.

BIOCHEM BIOPH RES CO.

2017 Jan 29;483(1):669-673.

(IF 2.985)

758. Yanzhao Chen, Baihai Jiao, Min Yao, Xuezhen Shi, Zhebin Zheng, Shilin Li Dr, Limin Chen Dr.

.

ISG12a inhibits HCV replication and potentiates the anti-HCV activity of IFN-α through activation of the Jak/STAT signaling pathway independent of autophagy and apoptosis.

Virus Research.

Volume 227, 2 January 2017, Pages 231-239.

(IF 2.736)

759. Jipeng Li, Ying Chen, Mingwei Jin, Jianhua Wang, Shanfeng Li, Zhe Chen, Wanjun Yu.

.

MicroRNA-134 reverses multidrug resistance in human lung adenocarcinoma cells by targeting FOXM1.

Oncology Letters.

January 5, 2017.

(IF 1.871)

760. Chen W, Shen X, Hu Y, Xu K, Ran Q, Yu Y, Dai L, Yuan Z, Huang L, Shen T, Cai K.

.

Surface functionalization of titanium implants with chitosan-catechol conjugate for suppression of ROS-induced cells damage and improvement of osteogenesis.

Biomaterials.

2017 Jan;114:82-96.

(IF 10.317)

761. Wang Q, Cheng N, Li X, Pan H, Li C, Ren S, Su C, Cai W, Zhao C, Zhang L, Zhou C.

.

Correlation of long non-coding RNA H19 expression with cisplatin-resistance and clinical outcome in lung adenocarcinoma.

ONCOTARGET.

2017 Jan 10;8(2):2558-2567.

(IF 5.168)

762. Liu B, Ren KD, Peng JJ, Li T, Luo XJ, Fan C, Yang JF, Peng J.

.

Suppression of NADPH oxidase attenuates hypoxia-induced dysfunctions of endothelial progenitor cells.

BIOCHEM BIOPH RES CO.

2017 Jan 22;482(4):1080-1087.

(IF 2.985)

763. Xie R, Zhang H, Wang XZ, Yang XZ, Wu SN, Wang HG, Shen P, Ma TH .

.

The protective effect of betulinic acid (BA) diabetic nephropathy on streptozotocin (STZ)-induced diabeticrats.

Food Funct.

2017 Jan 25;8(1):299-306.

(IF 4.171)

764. Shen CT, Wei WJ, Qiu ZL, Song HJ, Zhang XY, Sun ZK, Luo QY.

.

Metformin reduces glycometabolism of papillary thyroid carcinoma in vitro and in vivo.

J Mol Endocrinol.

2017 Jan;58(1):15-23.

(IF 3.562)

765. Li H, Zhang X, Jiang X, Ji X.

.

The expression and function of epithelial membrane protein 1 in laryngeal carcinoma.

Int J Oncol.

2017 Jan;50(1):141-148.

(IF 3.899)

766. Chen Y, Huang L, Zhang H, Diao X, Zhao S, Zhou W.

.

Reduction in Autophagy by (-)-Epigallocatechin-3-Gallate (EGCG): a Potential Mechanism of Prevention ofMitochondrial Dysfunction After Subarachnoid Hemorrhage.

Mol Neurobiol.

2017 Jan;54(1):392-405.

(IF 4.5)

767. Wang Z, Xiong L, Wang G, Wan W, Zhong C, Zu H.

.

Insulin-like growth factor-1 protects SH-SY5Y cells against β-amyloid-induced apoptosis via the PI3K/Akt-Nrf2 pathway.

Exp Gerontol.

2017 Jan;87(Pt A):23-32.

(IF 3.376)

768. Li M, Yuan Y, Hu B, Wu L.

.

Study on Lentivirus-Mediated ABCA7 Improves Neurocognitive Function and Related Mechanisms in theC57BL/6 Mouse Model of Alzheimer's Disease.

J Mol Neurosci.

2017 Jan 26. doi: 10.1007/s12031-017-0889-x. [Epub ahead of print]

(IF 2.678)

769. Xiaonian Zhu, Meng Yan, Wei Luo, Wei Liu, Yuan Ren, Chunhua Bei, Guifang Tang, Ruiling Chen, Shengkui Tan.

.

Expression and clinical significance of PcG-associated protein RYBP in hepatocellular carcinoma.

Oncology Letters.

January 2017, Volume 13 Issue 1.

(IF 1.871)

770. Wang Z, Liao K, Zuo W, Liu X, Qiu Z, Gong Z, Liu C, Zeng Q, Qian Y, Jiang L, Bu Y, Hong S, Hu G.

.

Depletion of NFBD1/MDC1 Induces Apoptosis in Nasopharyngeal Carcinoma Cells Through the p53-ROS-Mitochondrial Pathway.

Oncol Res.

2017 Jan 2;25(1):123-136.

(IF 4.949)

771. Dong L, Yin L, Zhang Y, Fu X, Lu J.

.

Anti-inflammatory effects of ononin on lipopolysaccharide-stimulated RAW 264.7 cells.

Mol Immunol.

2017 Jan 14;83:46-51.

(IF 3.641)

772. Du JY, Yuan F, Zhao LY, Zhu J, Huang YY, Zhang GS, Wei Y, Liu Y, Yi Q, Tu YS, Zhong X, Sun FY, Sun HS, Guan YY, Chen WL, Wang GL.

.

Suppression of Kv1.5 protects against endothelial apoptosis induced by palmitate and in type 2 diabetesmice.

Life Sci.

2017 Jan 1;168:28-37.

(IF 3.647)

773. Dai C, Lei L, Li B, Lin Y, Xiao X, Tang S.

.

Involvement of the activationof Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin.

TOXICOL MECH METHOD.

2017 Jan 8:1-8.

(IF 2.295)

774. Qin L, Sun Y, Zhao Y, Xu J, Bi K.

.

In vitro model to estimate Edwardsiella tarda-macrophage interactions using RAW264.7 cells.

FISH SHELLFISH IMMUN.

2017 Jan;60:177-184.

(IF 3.298)

775. Tingting Wang, Pei Wang, Zhizhong Cao, Xingxing Wang, Dalin Wang, Yaxian Shen, Da Jing, Erping Luo, Weizhong Tang.

.

Effects of BMP9 and pulsed electromagnetic fields on the proliferation and osteogenic differentiation of human periodontal ligament stem cells.

BIOELECTROMAGNETICS.

Volume38, Issue1, January 2017, Pages 63-77.

(IF 2.278)

776. Miao Song, Hui Huo, Zheng Cao, Yanfei Han, Li Gao.

.

Aluminum Trichloride Inhibits the Rat Osteoblasts Mineralization In Vitro.

Biological Trace Element Research.

January 2017, Volume 175, Issue 1, pp 186–193.

(IF 2.431)

777. Wang P, Wang Y, Tang W, Wang X, Pang Y, Yang S, Wei Y, Gao H, Wang D, Cao Z.

.

Bone Morphogenetic Protein-9 Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells via the JNK Pathway.

PLoS One.

2017 Jan 4;12(1):e0169123.

(IF 2.74)

778. Lu X, Yang L, Chen J, Zhou J, Tang X, Zhu Y, Qiu H, Shen J.

.

The action and mechanism of myrislignan on A549 cells in vitro and in vivo.

J NAT MED-TOKYO.

2017 Jan;71(1):76-85.

(IF 2.055)

779. Wu X, Fu Y, Sun X, Liu C, Chai M, Chen C, Dai L, Gao Y, Jiang H, Zhang J .

.

The possible FAT1-mediated apoptotic pathways in porcine cumulus cells.

Cell Biol Int.

2017 Jan;41(1):24-32.

(IF 2.571)

780. Zhou L, Chen X, Liu T, Zhu C, Si M, Jargstorf J, Li M, Pan G, Gong Y, Luo ZP, Yang H, Pei M, He F .

.

SIRT1-dependent anti-senescence effects of cell-deposited matrix on human umbilical cord mesenchymalstem cells.

J TISSUE ENG REGEN M.

2017 Jan 20. doi: 10.1002/term.2422. [Epub ahead of print]

(IF 3.078)

781. Liu J, Jiang X, Zhang Q, Lin S, Zhu J, Zhang Y, Du J, Hu X, Meng W, Zhao Q .

.

Neuroprotective effects of Kukoamine A against cerebral ischemia via antioxidant and inactivation ofapoptosis pathway.

Neurochem Int.

2017 Jan 11. pii: S0197-0186(16)30187-5.

(IF 3.881)

782. Wang P, Wang Y, Tang W, Wang X, Pang Y, Yang S, Wei Y, Gao H, Wang D, Cao Z .

.

Bone Morphogenetic Protein-9 Enhances Osteogenic Differentiation of Human Periodontal Ligament StemCells via the JNK Pathway.

PLoS One.

2017 Jan 4;12(1):e0169123.

(IF 2.74)

783. Cui L, Li Z, Chang X, Cong G, Hao L .

.

Quercetin attenuates vascular calcification by inhibiting oxidative stress and mitochondrial fission.

VASC PHARMACOL.

2017 Jan;88:21-29.

(IF 4.152)

784. Fang Li, Yu Zhang, Donglin Zeng, Yu Xia, Xiaoxue Fan, Yisha Tan, Junping Kou, Boyang Yu.

.

The Combination of Three Components Derived from Sheng MaiSan Protects Myocardial Ischemic Diseases and Inhibits Oxidative Stress via Modulating MAPKs and JAK2-STAT3 Signaling Pathways Based on Bioinformatics Approach.

ORIGINAL RESEARCH ARTICLE.

31 January 2017.

785. Zhu Y, Wang Y, Yao R, Hao T, Cao J, Huang H, Wang L, Wu Y .

.

Enhanced neuroinflammation mediated by DNA methylation of the glucocorticoid receptor triggerscognitive dysfunction after sevoflurane anesthesia in adult rats subjected to maternal separation during theneonatal period.

J NEUROINFLAMM.

2017 Jan 7;14(1):6.

(IF 5.793)

786. Liu B, Gu X, Huang T, Luan Y, Ding X .

.

Identification of TMPRSS2-ERG mechanisms in prostate cancer invasiveness: Involvement of MMP-9 andplexin B1.

Oncol Rep.

2017 Jan;37(1):201-208.

(IF 3.417)

787. Fan Y, Shi C, Li T, Kuang T .

.

microRNA-454 shows anti-angiogenic and anti-metastatic activity in pancreatic ductal adenocarcinoma bytargeting LRP6.

Am J Cancer Res.

2017 Jan 1;7(1):139-147.

(IF 5.177)

788. Luo L, Chen WJ, Yin JQ, Xu RX.

.

EID3 directly associates with DNMT3A during transdifferentiation of human umbilical cord mesenchymal stem cells to NPC-like cells.

SCI REP-UK.

2017 Jan 11;7:40463.

(IF 3.998)

789. Zhao H, Xue Y, Guo Y, Sun Y, Liu D, Wang X .

.

Inhibition of endocan attenuates monocrotaline-induced connective tissue disease related pulmonaryarterial hypertension.

Int Immunopharmacol.

2017 Jan;42:115-121.

(IF 3.943)

790. Wang C, Wang Q, Li X, Jin Z, Xu P, Xu N, Xu A, Xu Y, Zheng S, Zheng J, Liu C, Huang P.

.

Lycorine induces apoptosis of bladder cancer T24 cells by inhibiting phospho-Akt and activating the intrinsic apoptotic cascade.

BIOCHEM BIOPH RES CO.

2017 Jan 29;483(1):197-202.

(IF 2.985)

791. Gao HT, Xu R, Cao WX, Qian LL, Wang M, Lu L, Xu Q, Yu SQ .

.

Effects of six priority controlled phthalate esters with long-term low-dose integrated exposure on malereproductive toxicity in rats.

Food Chem Toxicol.

2017 Jan 12;101:94-104.

(IF 4.679)

792. You F, Li Q, Jin G, Zheng Y, Chen J, Yang H .

.

Genistein protects against Aβ25-35 induced apoptosis of PC12 cells through JNK signaling and modulationof Bcl-2 family messengers.

BMC Neurosci.

2017 Jan 12;18(1):12.

(IF 2.811)

793. Wang C, Wang Q, Li X, Jin Z, Xu P, Xu N, Xu A, Xu Y, Zheng S, Zheng J, Liu C, Huang P .

.

Lycorine induces apoptosis of bladder cancer T24 cells by inhibiting phospho-Akt and activating theintrinsic apoptotic cascade.

BIOCHEM BIOPH RES CO.

2017 Jan 29;483(1):197-202.

(IF 2.985)

794. Wang X, Zhang Y, Lin H, Liu Y, Tan Y, Lin J, Gao F, Lin S.

.

Alpha2,3-sialyltransferase III knockdown sensitized ovarian cancer cells to cisplatin-induced apoptosis.

BIOCHEM BIOPH RES CO.

2017 Jan 22;482(4):758-763.

(IF 2.985)

795. Zhang T, Zhao L, Zeng S, Bai L, Chen J, Zhang Z, Wang Y, Duan C.

.

UHRF2 decreases H3K9ac expression by interacting with it through the PHD and SRA/YDG domain in HepG2 hepatocellular carcinoma cells.

Int J Mol Med.

2017 Jan;39(1):126-134.

(IF 3.098)

796. Ma C, Wang Y, Shen A, Cai W .

.

Resveratrol upregulates SOCS1 production by lipopolysaccharide-stimulated RAW264.7 macrophages byinhibiting miR-155.

Int J Mol Med.

2017 Jan;39(1):231-237.

(IF 3.098)

797. Zhang Y, Wu JY, Weng LH, Li XX, Yu LJ, Xu Y.

.

Valproic acid protects against MPP+-mediated neurotoxicity in SH-SY5Y Cells through autophagy.

Neurosci Lett.

2017 Jan 18;638:60-68.

(IF 2.274)

798. Wang T, Hou J, Su C, Zhao L, Shi Y .

.

Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhanceantitumor efficiency by targeted drug delivery via CD44.

J NANOBIOTECHNOL.

2017 Jan 10;15(1):7.

(IF 6.518)

799. Zhang L, Xu Y, Sun J, Chen W, Zhao L, Ma C, Wang Q, Sun J, Huang B, Zhang Y, Li X, Qu X.

.

M2-like tumor-associated macrophages drive vasculogenic mimicry through amplification of IL-6 expression in glioma cells.

ONCOTARGET.

2017 Jan 3;8(1):819-832.

(IF 5.168)

800. Hou L, Zhang J, Zhang C, Xu Y, Zhu X, Yao C, Liu Y, Li T, Cao J.

.

The injury of fine particulate matter from cooking oil fumes on umbilical cord blood vessels in vitro.

ENVIRON TOXICOL CHEM.

2017 Jan;49:65-73.

(IF 3.152)

801. Zhou Y, Wang X, Zhao Y, Liu A, Zhao T, Zhang Y, Shan Z, Teng W.

.

Elevated Thyroid Peroxidase Antibody Increases Risk of Post-partum Depression by Decreasing Prefrontal Cortex BDNF and 5-HT Levels in Mice.

Front Cell Neurosci.

2017 Jan 9;10:307.

(IF 3.921)

802. Wang T, Hou J, Su C, Zhao L, Shi Y.

.

Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44.

J NANOBIOTECHNOL.

2017 Jan 10;15(1):7.

(IF 6.518)

803. Zhang J, Su L, Ye Q, Zhang S, Kung H, Jiang F, Jiang G, Miao J, Zhao B.

.

Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells.

ONCOTARGET.

2017 Jan 31;8(5):7625-7636.

(IF 5.168)

804. Zhang ML, Fu FH, Yu LC.

.

Antinociception induced by galanin in anterior cingulate cortex in rats with acute inflammation.

Neurosci Lett.

2017 Jan 18;638:156-161.

(IF 2.274)

805. Xiao Q, Huang L, Zhang Z, Chen X, Luo J, Zhang Z, Chen S, Shu Y, Han Z, Cao K.

.

Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4.

Oncol Res.

2017 Jan 26;25(2):267-275.

(IF 4.949)

806. Fan Y, Shi C, Li T, Kuang T.

.

microRNA-454 shows anti-angiogenic and anti-metastatic activity in pancreatic ductal adenocarcinoma by targeting LRP6.

Am J Cancer Res.

2017 Jan 1;7(1):139-147. eCollection 2017.

(IF 5.177)

807. Du JY, Yuan F, Zhao LY, Zhu J, Huang YY, Zhang GS, Wei Y, Liu Y, Yi Q, Tu YS, Zhong X, Sun FY, Sun HS, Guan YY, Chen WL, Wang GL.

.

Suppression of Kv1.5 protects against endothelial apoptosis induced by palmitate and in type 2 diabetes mice.

Life Sci.

2017 Jan 1;168:28-37.

(IF 3.647)

808. Xiong J, Liu Y, Luo S, Jiang L, Zeng Y, Chen Z, Shi X, Lv B, Tang W.

.

High expression of the long non-coding RNA HEIRCC promotes Renal Cell Carcinoma metastasis by inducing epithelial-mesenchymal transition.

ONCOTARGET.

2017 Jan 24;8(4):6555-6563.

(IF 5.168)

809. Li A, Li J, Lin J, Zhuo W, Si J.

.

COL11A1 is overexpressed in gastric cancer tissues and regulates proliferation, migration and invasion of HGC-27 gastric cancer cells in vitro.

Oncol Rep.

2017 Jan;37(1):333-340.

(IF 3.417)

810. Zhao H, Xue Y, Guo Y, Sun Y, Liu D, Wang X.

.

Inhibition of endocan attenuates monocrotaline-induced connective tissue disease related pulmonary arterial hypertension.

Int Immunopharmacol.

2017 Jan;42:115-121.

(IF 3.943)

811. Lingman Ma, Lifen Qian, Qidi Ying, Yan Zhang, Changlin Zhou, Guanzhong Wu.

.

I4, a synthetic anti-diabetes agent, attenuates atherosclerosis through its lipid-lowering, anti-inflammatory and anti-apoptosis properties.

Molecular and Cellular Endocrinology.

15 January 2017, Pages 80-92.

(IF 3.693)

812. Liu B, Gu X, Huang T, Luan Y, Ding X.

.

Identification of TMPRSS2-ERG mechanisms in prostate cancer invasiveness: Involvement of MMP-9 and plexin B1.

Oncol Rep.

2017 Jan;37(1):201-208.

(IF 3.417)

813. Yu L, Li N, Zhang J, Jiang Y.

.

IL-13 regulates human nasal epithelial cell differentiation via H3K4me3 modification.

INFLAMM RES.

2017 Jan 9;10:181-188.

(IF 3.174)

814. You F, Li Q, Jin G, Zheng Y, Chen J, Yang H.

.

Genistein protects against Aβ25-35 induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers.

BMC Neurosci.

2017 Jan 12;18(1):12.

(IF 2.811)

815. Ma C, Pi C, Yang Y, Lin L, Shi Y, Li Y, Li Y, He X.

.

Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1.

PLoS One.

2017 Jan 26;12(1):e0170930.

(IF 2.74)

816. Luyao Song, Liwen Tian, Yun Ma, Yang Xie, Haixing Feng, Fei Qin, Liqian Mo, Si Lin, Lianbing Hou, Chunxia Wang.

.

Protection of flavonoids from Smilax china L. rhizome on phenol mucilage-induced pelvic inflammation in rats by attenuating inflammation and fibrosis.

Journal of Functional Foods.

January 2017, Pages 194-204.

(IF 3.197)

817. Chen HM, Luo H, Zeng WB, Liu B, Huang JC, Liu M, Zeng YJ, Zheng Q, Li JQ, Sun XG, Zhou YC.

.

Salvianolic acid B attenuates oxidized low-density lipoprotein-induced endothelial cell apoptosis through inhibition of oxidative stress, p53, and caspase-3 pathways.

Chin J Integr Med.

2017 Jan 24.

(IF 1.545)

818. Zhu Y, Wang Y, Yao R, Hao T, Cao J, Huang H, Wang L, Wu Y.

.

Enhanced neuroinflammation mediated by DNA methylation of the glucocorticoid receptor triggers cognitive dysfunction after sevoflurane anesthesia in adult rats subjected to maternal separation during the neonatal period.

J NEUROINFLAMM.

2017 Jan 7;14(1):6.

(IF 5.793)

819. Han Y, Zhao Q, Zhou J, Shi R.

.

miR-429 mediates tumor growth and metastasis in colorectal cancer.

Am J Cancer Res.

2017 Feb 1;7(2):218-233. eCollection 2017.

(IF 5.177)

820. Chao Zhao, Yan Wang, Mingjun Fu, Keng Yang, Lihua Qiu.

.

Molecular cloning, expression and functional analysis of three subunits of protein phosphatase 2A (PP2A) from black tiger shrimps (Penaeus monodon).

COMP BIOCHEM PHYS B.

Volume 204, February 2017, Pages 77-89.

(IF 2.219)

821. Juan Wang, Liping Guo, Difei Shen, Xiao Xu, Jiaping Wang, Suxia Han, Wen He.

.

The Role of c‐SKI in Regulation of TGFβ‐Induced Human Cardiac Fibroblast Proliferation and ECM Protein Expression.

Journal Of Cellular Biochemistry.

18 February 2017.

(IF 3.448)

822. Jiang XS, Chen XM, Wan JM, Gui HB, Ruan XZ, Du XG.

.

Autophagy Protects against Palmitic Acid-Induced Apoptosis in Podocytes in vitro.

SCI REP-UK.

2017 Feb 22;7:42764.

(IF 3.998)

823. Han D, Chen W, Gu X, Shan R, Zou J, Liu G, Shahid M, Gao J, Han B.

.

Cytoprotective effect of chlorogenic acid against hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells through PI3K/Akt-mediated Nrf2/HO-1 signaling pathway.

ONCOTARGET.

2017 Feb 28;8(9):14680-14692.

(IF 5.168)

824. Ming-Jenn Chen, Ya-Min Cheng, Chien-Chung Chend, Yu-Chieh Chen, Ching-JuShen.

.

MiR-148a and miR-152 reduce tamoxifen resistance in ER+ breast cancer via downregulating ALCAM.

Biochemical and Biophysical Research Communications.

Volume 483, Issue 2, 5 February 2017, Pages 840-846.

(IF 2.705)

825. Huang T, Liu R, Fu X, Yao D, Yang M, Liu Q, Lu WW, Wu C, Guan M .

.

Aging Reduces an ERRalpha-Directed Mitochondrial Glutaminase Expression Suppressing GlutamineAnaplerosis and Osteogenic Differentiation of Mesenchymal Stem Cells.

Stem Cells.

2017 Feb;35(2):411-424.

(IF 6.022)

826. Liu WY, Zhang JW, Yao XQ, Jiang C, He JC, Ni P, Liu JL, Chen QY, Li QR, Zang XJ, Yao L, Liu YZ, Wang ML, Shen PQ, Wang GJ, Zhou F .

.

Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers viaimproving their subcellular distribution.

Acta Pharmacol Sin.

2017 Feb;38(2):264-276.

(IF 5.064)

827. Ruqin Peng, Shaozhan Wang, Rong Wang, Yuanyuan Wang, Yan Wu, Yongfang Yuan.

.

Antifibrotic Effects of Tanshinol in Experimental Hepatic Fibrosis by Targeting PI3K/AKT/mTOR/p70S6K1 Signaling Pathways.

Discovery Medicine.

February 19, 2017.

(IF 1.929)

828. Hu J, Zhai C, Hu J, Li Z, Fei H, Wang Z, Fan W.

.

MiR-23a inhibited IL-17-mediated proinflammatory mediators expression via targeting IKKα in articular chondrocytes.

Int Immunopharmacol.

2017 Feb;43:1-6.

(IF 3.943)

829. Chen H, Yan L, Wang J, Sun Y, Li X, Zhao S, Wang D, Zhu G, Liang Y.

.

Methotrexate prevents epidural fibrosis through endoplasmic reticulum stress signalling pathway.

Eur J Pharmacol.

2017 Feb 5;796:131-138.

(IF 3.263)

830. Dongqing Zuo, Zifei Zhou, Hongsheng Wang, Tao Zhang, Jie Zang, Fei Yin, Wei Sun, Jiepeng Chen, Lili Duan, Jing Xu, Zhuoying Wang, Chongren Wang, Binhui Lin, Zeze Fu, Yuxin Liao, Suoyuan Li, Mengxiong Sun, Yingqi Hua, Longpo Zheng, Zhengdong Cai.

.

Alternol, a natural compound, exerts an anti‐tumour effect on osteosarcoma by modulating of STAT3 and ROS/MAPK signalling pathways.

Journal of Cellular and Molecular Medicine.

Volume21, Issue2, February 2017, Pages 208-221.

(IF 4.658)

831. Jiang W, Chen Q, Li P, Lu Q, Pei X, Sun Y, Wang G, Hao K.

.

Magnesium Isoglycyrrhizinate attenuates lipopolysaccharide-induced depressive-like behavior in mice.

Biomed Pharmacother.

2017 Feb;86:177-184.

(IF 4.545)

832. Yonggang Zhu, Hongguang Zhao, Min Rao, Songbai Xu.

.

MicroRNA-365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3.

Oncology Reports.

February 16, 2017, Pages: 2185-2192.

(IF 3.041)

833. Luan W, Qian Y, Ni X, Bu X, Xia Y, Wang J, Ruan H, Ma S, Xu B.

.

miR-204-5p acts as a tumor suppressor by targeting matrix metalloproteinases-9 and B-cell lymphoma-2 in malignant melanoma.

ONCOTARGETS THER.

2017 Feb 27;10:1237-1246.

(IF 3.337)

834. Fang A, Li X, Wang Y, Pan D, Wang Q.

.

A core component of the CUL4 ubiquitin ligase complexes, DDB1, regulates spermatogenesis in theChinese mitten crab, Eriocheir sinensis.

Gene.

2017 Feb 15;601:11-20.

(IF 2.984)

835. Liu Y, Wang F, Xu P.

.

miR-590 accelerates lung adenocarcinoma migration and invasion through directly suppressingfunctionaltarget OLFM4.

Biomed Pharmacother.

2017 Feb;86:466-474.

(IF 4.545)

836. Yang Y, Dong Q, Li R.

.

Matrine induces the apoptosis of fibroblast-like synoviocytes derived from rats with collagen-inducedarthritis by suppressing the activation of the JAK/STAT signaling pathway.

Int J Mol Med.

2017 Feb;39(2):307-316.

(IF 3.098)

837. Wang Y, Gu YH, Liu M, Bai Y, Wang HL.

.

Fluoxetine protects against methamphetamine induced lung inflammation by suppressing

Mol Med Rep.

2017 Feb;15(2):673-680.

(IF 2.1)

838. Zhang L, Xiong W, Li N, Liu H, He H, Du Y, Zhang Z, Liu Y.

.

Estrogen stabilizes hypoxia-inducible factor 1α through G protein-coupled estrogen receptor 1 in eutopicendometrium of endometriosis.

Fertil Steril.

2017 Feb;107(2):439-447.

(IF 6.312)

839. Cui D, Xu J, Xu Q, Zuo G.

.

DL-2-amino-3-phosphonopropionic acid protects primary neurons from oxygen-glucose deprivation induced injury.

BOSNIAN J BASIC MED.

2017 Feb 21;17(1):12-16.

(IF 2.05)

840. Wang M, Wang Q, Peng WJ, Hu JF, Wang ZY, Liu H, Huang LN .

.

Testin is a tumor suppressor in non-small cell lung cancer.

Oncol Rep.

2017 Feb;37(2):1027-1035.

(IF 3.417)

841. Han Luo, Dai-Jun Zhou, Zhang Chen, Qi-Quan Zhou, Kui Wu, Kun Tian, Zhi-Wei Li, Zhen-Liang Xiao.

.

Establishment and evaluation of an experimental rat model for high-altitude intestinal barrier injury.

Experimental and Therapeutic Medicine.

February 2017, Volume 13 Issue 2.

(IF 1.448)

842. Chen S, Sun YY, Zhang ZX, Li YH, Xu ZM, Fu WN.

.

Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3β-involved Wnt/β-catenin pathway.

ONCOTARGET.

2017 Feb 28;8(9):14708-14718.

(IF 5.168)

843. Zhang XG, Zhao L, Zhang Y, Li YY, Wang H, Duan GL, Xiao L, Li XR, Chen HP .

.

Extracellular Cl--free-induced cardioprotection against hypoxia/reoxygenation is associated withattenuation of mitochondrial permeability transition pore.

Biomed Pharmacother.

2017 Feb;86:637-644.

(IF 4.545)

844. Wu J, Liu Z, Su J, Pan N, Song Q .

.

Anti-inflammatory activity of 3β-hydroxycholest-5-en-7-one isolated from Hippocampus trimaculatus leachvia inhibiting iNOS, TNF-α, and 1L-1β of LPS induced RAW 264.7 macrophage cells.

Food Funct.

2017 Feb 22;8(2):788-795.

(IF 4.171)

845. Di YF, Li DC, Shen YQ, Wang CL, Zhang DY, Shang AQ, Hu T.

.

MiR-146b protects cardiomyocytes injury in myocardial ischemia/reperfusion by targeting Smad4.

Am J Transl Res.

2017 Feb 15;9(2):656-663. eCollection 2017.

(IF 3.375)

846. Wei B, Wei W, Zhao B, Guo X, Liu S.

.

Long non-coding RNA HOTAIR inhibits miR-17-5p to regulate osteogenic differentiation and proliferation in non-traumatic osteonecrosis of femoral head.

PLoS One.

2017 Feb 16;12(2):e0169097.

(IF 2.74)

847. Xu J, Wu W, Wang J, Huang C, Wen W, Zhao F, Xu X, Pan X, Wang W, Zhu Q, Chen L.

.

miR-367 promotes the proliferation and invasion of non-small cell lung cancer via targeting FBXW7.

Oncol Rep.

2017 Feb;37(2):1052-1058.

(IF 3.417)

848. Guopei Zhang, Yangyang Guan, Yuejiao Zhao, Taharvan der Straaten, Sha Xiao, Ping Xue, Guolian Zhu, Qiufang Liu, Yuan Cai, Cuihong Jin, Jinghua Yang, Shengwen Wu, Xiaobo Lu.

.

ERCC2/XPD Lys751Gln alter DNA repair efficiency of platinum-induced DNA damage through P53 pathway.

Chemico-Biological Interactions.

Volume 263, 1 February 2017, Pages 55-65.

(IF 3.407)

849. Lu C, Shan Z, Li C, Yang L.

.

MiR-129 regulates cisplatin-resistance in human gastric cancer cells by targeting P-gp.

Biomed Pharmacother.

2017 Feb;86:450-456.

(IF 4.545)

850. Hu J, Zhai C, Hu J, Li Z, Fei H, Wang Z, Fan W .

.

MiR-23a inhibited IL-17-mediated proinflammatory mediators expression via targeting IKKα in articularchondrocytes.

Int Immunopharmacol.

2017 Feb;43:1-6.

(IF 3.943)

851. Shen H, Wu N, Liu Z, Zhao H, Zhao M .

.

Epigallocatechin-3-gallate alleviates paraquat-induced acute lung injury and inhibits upregulation of toll-likereceptors.

Life Sci.

2017 Feb 1;170:25-32.

(IF 3.647)

852. Chen X, Ye H, Li S, Jiao B, Wu J, Zeng P, Chen L.

.

Severe fever with thrombocytopenia syndrome virus inhibits exogenous Type I IFN signaling pathway through its NSs invitro.

PLoS One.

2017 Feb 24;12(2):e0172744.

(IF 2.74)

853. Liu WY, Zhang JW, Yao XQ, Jiang C, He JC, Ni P, Liu JL, Chen QY, Li QR, Zang XJ, Yao L, Liu YZ, Wang ML, Shen PQ, Wang GJ, Zhou F.

.

Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution.

Acta Pharmacol Sin.

2017 Feb;38(2):264-276.

(IF 5.064)

854. Yu Y, Liu C, Zhang J, Zhang M, Wen W, Ruan X, Li D, Zhang S, Gao M, Chen L.

.

Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and in vivo Thyroid Function.

SCI REP-UK.

2017 Feb 23;7:43396.

(IF 3.998)

855. Liu Y, Wang F, Xu P.

.

miR-590 accelerates lung adenocarcinoma migration and invasion through directly suppressing functional target OLFM4.

Biomed Pharmacother.

2017 Feb;86:466-474.

(IF 4.545)

856. Liu Q, Yu Z, Yuan S, Xie W, Li C, Hu Z, Xiang Y, Wu N, Wu L, Bai L, Li Y.

.

Circulating exosomal microRNAs as prognostic biomarkers for non-small-cell lung cancer.

ONCOTARGET.

2017 Feb 21;8(8):13048-13058.

(IF 5.168)

857. Zhou C, Bai J, Jiang C, Ye L, Pan Y, Zhang H.

.

Geranylgeranylacetone attenuates myocardium ischemic/reperfusion injury through HSP70 and Akt/GSK-3β/eNOS pathway.

Am J Transl Res.

2017 Feb 15;9(2):386-395. eCollection 2017.

(IF 3.375)

858. Wu J, Liu Z, Su J, Pan N, Song Q.

.

Anti-inflammatory activity of 3β-hydroxycholest-5-en-7-one isolated from Hippocampus trimaculatus leach via inhibiting iNOS, TNF-α, and 1L-1β of LPS induced RAW 264.7 macrophage cells.

Food Funct.

2017 Feb 22;8(2):788-795.

(IF 4.171)

859. Liu Z, Gu H, Gan L, Xu Y, Feng F, Saeed M, Sun C.

.

Reducing Smad3/ATF4 was essential for Sirt1 inhibiting ER stress-induced apoptosis in mice brown adipose tissue.

ONCOTARGET.

2017 Feb 7;8(6):9267-9279.

(IF 5.168)

860. Shi X, Yu W, Liu L, Liu W, Zhang X, Yang T, Chai L, Lou L, Gao Y, Zhu L.

.

Panax notoginseng saponins administration modulates pro- /anti-inflammatory factor expression and improves neurologic outcome following permanent MCAO in rats.

Metab Brain Dis.

2017 Feb;32(1):221-233.

(IF 2.726)

861. Yan-Yan Wang, Lu-Nan Qi, Jian-Hong Zhong, Hong-Gui Qin, Jia-Zhou Ye, Shi-Dong Lu, Liang Ma, Bang-De Xiang, Le-Qun Li, Xue-Mei You.

.

High expression of AKR1B10 predicts low risk of early tumor recurrence in patients with hepatitis B virus-related hepatocellular carcinoma.

Scientific Reports.

09 February 2017.

(IF 4.011)

862. Lu Xiaoyan, Jin Tingting, Zheng Jie, Fan Xiaohui.

.

The Size and Surface Modification of Amorphous Silica Particles Affect the Biological Processes in Murine Macrophages.

Journal of Nanoscience and Nanotechnology.

February 2017, pp. 954-967(14).

(IF 1.093)

863. Jiang P, Wei WF, Zhong GW, Zhou XG, Qiao WR, Fisher R, Lu L.

.

The function of the three phosphoribosyl pyrophosphate synthetase (Prs) genes in hyphal growth and conidiation in Aspergillus nidulans.

Microbiology.

2017 Feb;163(2):218-232.

(IF 1.027)

864. Yanan An, Xiaochen Shi, Xudong Tang, Yang Wang, Fengge Shen, Qiaoli Zhang, Chao Wang, Mingguo Jiang, Mingyuan Liu, Lu Yu.

.

Aflatoxin B1 Induces Reactive Oxygen Species-Mediated Autophagy and Extracellular Trap Formation in Macrophages.

FRONT CELL INFECT MI.

23 February 2017.

(IF 4.123)

865. Hong W, Shi H, Qiao M, Zhang Z, Yang W, Dong L, Xie F, Zhao C, Kang L.

.

pH-sensitive micelles for the intracellular co-delivery of curcumin and Pluronic L61 unimers for synergistic reversal effect of multidrug resistance.

SCI REP-UK.

2017 Feb 14;7:42465.

(IF 3.998)

866. Dongwu Lai, Jing Gao, Xukun Bi, Hong He, Xiaolu Shi, Shaoxiang Weng, Yu Chen, Ying Yang, Yang Ye, Guosheng Fu.

.

The Rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling.

J MOL MED.

February 2017, Volume 95, Issue 2, pp 155–165.

(IF 4.427)

867. Zhang JX, Wang R, Xi J, Shen L, Zhu AY, Qi Q, Wang QY, Zhang LJ, Wang FC, Lü HZ, Hu JG.

.

Morroniside protects SK-N-SH human neuroblastoma cells against H2O2-induced damage.

Int J Mol Med.

2017 Feb 8.

(IF 3.098)

868. AnYu Fang, XueJie Li, YuanLi Wang, DiYue Pan, Qun Wang.

.

A core component of the CUL4 ubiquitin ligase complexes, DDB1, regulates spermatogenesis in the Chinese mitten crab, Eriocheir sinensis.

Gene.

Volume 601, 15 February 2017, Pages 11-20.

(IF 2.984)

869. Weiwei Wang, Lijun Zhang, Liang Liu, Yongfa Zheng, Yong Zhang, Siyuan Yang, Rongliang Shi, Shaojia Wang.

.

Chemosensitizing effect of shRNA-mediated ERCC1 silencing on a Xuanwei lung adenocarcinoma cell line and its clinical significance.

Oncology Reports.

February 14, 2017.

(IF 3.041)

870. Xintian Zheng, Xiaoyan Yang, Xiaohua Li, Guo-Hua Qiu, Ailing Dai, Qichun Huang, Cuiqin Huang, Xiaofeng Guo.

.

Omp16-based vaccine encapsulated by alginate-chitosan microspheres provides significant protection against Haemophilus parasuis in mice.

Vaccine.

7 March 2017, Pages 1417-1423.

(IF 3.143)

871. Jiang Q, Li Q, Han J, Gou M, Zheng Y, Li B, Xiao R, Wang J .

.

rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration andinvasion of human HeyA8 cells via FAK pathway.

Int J Biol Macromol.

2017 Mar;96:652-668.

(IF 5.162)

872. Zhou F, Zhang W, Zhou J, Li M, Zhong F, Zhang Y, Liu Y, Wang Y.

.

Involvement of endoplasmic reticulum stress in formalin-induced pain is attenuated by 4-phenylbutyric acid.

J Pain Res.

2017 Mar 20;10:653-662.

(IF 2.386)

873. Gao R, Chen R, Cao Y, Wang Y, Song K, Zhang Y, Yang J .

.

Emodin suppresses TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells throughNotch signaling pathway.

TOXICOL APPL PHARM .

2017 Mar 1;318:1-7.

(IF 3.616)

874. Wulong Liang, Minping Zheng, Changlei Bao, Yanming Zhang.

.

CSFV proliferation is associated with GBF1 and Rab2.

Journal of Biosciences.

March 2017, Volume 42, Issue 1, pp 43–56.

(IF 1.823)

875. Chen H, Tang X, Zhou B, Xu N, Zhou Z, Fang K, Wang Y.

.

BDE-47 and BDE-209 inhibit proliferation of Neuro-2a cells via inducing G1-phase arrest.

ENVIRON TOXICOL CHEM.

2017 Mar;50:76-82.

(IF 3.152)

876. Cuiyuan Huang, Linghui Pan, Fei Lin, Huijun Dai, Ruili Fu.

.

Monoclonal antibody against Toll-like receptor 4 attenuates ventilator-induced lung injury in rats by inhibiting MyD88- and NF-κB-dependent signaling.

International Journal of Molecular Medicine.

March 2017, Volume 39 Issue 3.

(IF 2.928)

877. Liu Z, Lu Y, Xiao Y, Lu Y.

.

Upregulation of miR-21 expression is a valuable predicator of advanced clinicopathological features and poor prognosis in patients with renal cell carcinoma through the p53/p21‑cyclin E2‑Bax/caspase-3 signaling pathway.

Oncol Rep.

2017 Mar;37(3):1437-1444.

(IF 3.417)

878. Jiang Q, Li Q, Han J, Gou M, Zheng Y, Li B, Xiao R, Wang J.

.

rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of human HeyA8 cells via FAK pathway.

Int J Biol Macromol.

2017 Mar;96:652-668.

(IF 5.162)

879. Daoliang Xu, Haiming Jin, Jianxia Wen, Jiaoxiang Chen, Deheng Chen, Ningyu Cai, Yongli Wang, Jianle Wang, Yu Chen, Xiaolei Zhang, Xiangyang Wang.

.

Hydrogen sulfide protects against endoplasmic reticulum stress and mitochondrial injury in nucleus pulposus cells and ameliorates intervertebral disc degeneration.

Pharmacological Research.

Volume 117, March 2017, Pages 357-369.

(IF 5.574)

880. Li H, Tang Y, Wen L, Kong X, Chen X, Liu P, Zhou Z, Chen W, Xiao C, Xiao P, Xiao X.

.

Neferine reduces cisplatin-induced nephrotoxicity by enhancing autophagy via the AMPK/mTOR signaling pathway.

BIOCHEM BIOPH RES CO.

2017 Mar 11;484(3):694-701.

(IF 2.985)

881. Liao X, Feng B, Zhang D, Liu P, Zhou X, Li R, Ye L.

.

The Sirt6 gene: Does it play a role in tooth development?

PLoS One.

2017 Mar 29;12(3):e0174255.

(IF 2.74)

882. Qiang Qu, Xiangdong Chu, Peng Wang.

.

MicroRNA-195-5p suppresses osteosarcoma cell proliferation and invasion by suppressing naked cuticle homolog 1.

Cell Biology International.

Volume41, Issue3, March 2017, Pages 287-295.

(IF 2.127)

883. Shoumin Bai, Ting Chen, Xiaoli Yu, Ming Luo, Xianju Chen, Chunhao Lin, Yiming Lai, Hai Huang.

.

The specific killing effect of matrine on castration-resistant prostate cancer cells by targeting the Akt/FoxO3a signaling pathway.

Oncology Reports.

March 16, 2017.

(IF 3.041)

884. Nian-Wei Yao, Yuan Lu, Li-Qi Shi, Feng Xu, Xian-Hua Cai.

.

Neuroprotective effect of combining tanshinone IIA with low‑dose methylprednisolone following acute spinal cord injury in rats.

Experimental and Therapeutic Medicine.

March 28, 2017.

(IF 1.448)

885. Wu D, Luo N, Wang L, Zhao Z, Bu H, Xu G, Yan Y, Che X, Jiao Z, Zhao T, Chen J, Ji A, Li Y, Lee GD.

.

Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways.

SCI REP-UK.

2017 Mar 28;7(1):455.

(IF 3.998)

886. Hou X, Yu Y, Feng J, Wang J, Zheng C, Ling Z, Ge M, Zhu X.

.

Biochemical changes of salivary gland adenoid cystic carcinoma cells induced by SGI-1776.

Exp Cell Res.

2017 Mar 15;352(2):403-411.

(IF 3.383)

887. Zhang Y, Takemori H, Wang C, Fu J, Xu M, Xiong L, Li N, Wen X.

.

Role of salt inducible kinase 1 in high glucose-induced lipid accumulation in HepG2 cells and metformin intervention.

Life Sci.

2017 Mar 15;173:107-115.

(IF 3.647)

888. He HQ, Wu YX, Nie YJ, Wang J, Ge M, Qian F.

.

LYRM03, an ubenimex derivative, attenuates LPS-induced acute lung injury in mice by suppressing the TLR4 signaling pathway.

Acta Pharmacol Sin.

2017 Mar;38(3):342-350.

(IF 5.064)

889. Xu X, Li R, Zhou Y, Zou Q, Ding Q, Wang J, Jin W, Hua G, Gao J.

.

Dysregulated systemic lymphocytes affect the balance of osteogenic/adipogenic differentiation of bone mesenchymal stem cells after local irradiation.

Stem Cell Res Ther.

2017 Mar 20;8(1):71.

(IF 5.116)

890. Li Y, Shen R, Wen G, Ding R, Du A, Zhou J, Dong Z, Ren X, Yao H, Zhao R, Zhang G, Lu Y, Wu X.

.

Effects of Ketamine on Levels of Inflammatory Cytokines IL-6, IL-1β, and TNF-α in the Hippocampus of Mice Following Acute or Chronic Administration.

Front Pharmacol.

2017 Mar 20;8:139.

(IF 4.225)

891. Gao HT, Xu R, Cao WX, Qian LL, Wang M, Lu L, Xu Q, Yu SQ.

.

Effects of six priority controlled phthalate esters with long-term low-dose integrated exposure on male reproductive toxicity in rats.

Food Chem Toxicol.

2017 Mar;101:94-104.

(IF 4.679)

892. Shen CJ, Kuo YL, Chen CC, Chen MJ, Cheng YM.

.

MMP1 expression is activated by Slug and enhances multi-drug resistance (MDR) in breast cancer.

PLoS One.

2017 Mar 23;12(3):e0174487.

(IF 2.74)

893. Chen L, Huang G, Gao M, Shen X, Gong W, Xu Z, Zeng Y, He F.

.

Chicoric acid suppresses BAFF expression in B lymphocytes by inhibiting NF-κB activity.

Int Immunopharmacol.

2017 Mar;44:211-215.

(IF 3.943)

894. Pan XP, Wang HX, Tong DM, Li Y, Huang LH, Wang C.

.

miRNA-370 acts as a tumor suppressor via the downregulation of PIM1 in hepatocellular carcinoma.

EUR REV MED PHARMACO.

2017 Mar;21(6):1254-1263.

(IF 3.024)

895. Cheng L, Zhan B, Luo P, Wang B.

.

miRNA‑375 regulates the cell survival and apoptosis of human non‑small cell carcinoma by targeting HER2.

Mol Med Rep.

2017 Mar;15(3):1387-1392.

(IF 2.1)

896. Sun Y, Zong L, Gao Z, Zhu S, Tong J, Cao Y.

.

Mitochondrial DNA damage and oxidative damage in HL-60 cells exposed to 900MHz radiofrequency fields.

MUTAT RES-REV MUTAT.

2017 Mar;797-799:7-14.

(IF 5.803)

897. He LF, Xu HW, Chen M, Xian ZR, Wen XF, Chen MN, Du CW, Huang WH, Wu JD, Zhang GJ.

.

Activated-PAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling.

ONCOTARGET.

2017 Mar 14;8(11):17573-17585.

(IF 5.168)

898. Zhang J, Cai Q, Jiang M, Liu Y, Gu H, Guo J, Sun H, Fang J, Jin L.

.

Mesencephalic astrocyte-derived neurotrophic factor alleviated 6-OHDA-induced cell damage via ROS-AMPK/mTOR mediated autophagic inhibition.

Exp Gerontol.

2017 Mar;89:45-56.

(IF 3.376)

899. Pu YZ, Wan QL, Ding AJ, Luo HR, Wu GS.

.

Quantitative proteomics analysis of Caenorhabditis elegans upon germ cell loss.

J Proteomics.

2017 Mar 6;156:85-93.

(IF 3.509)

900. Wang K, Xu Y, Yang W, Zhang Y.

.

Insufficient hypothalamic angiotensin-converting enzyme 2 is associated with hypertension in SHR rats.

ONCOTARGET.

2017 Mar 21;8(12):20244-20251.

(IF 5.168)

901. Lu Li, Lu Wang, Kevin M Prise, KN Yu, Guodong Chen, Lianyun Chen, Yide Mei, Wei Han.

.

Akt/mTOR mediated induction of bystander effect signaling in a nucleus independent manner in irradiated human lung adenocarcinoma epithelial cells.

ONCOTARGET.

2017 Mar 14; 8(11): 18010–18020.

(IF 5.168)

902. Wei R, Yang Q, Han B, Li Y, Yao K, Yang X, Chen Z, Yang S, Zhou J, Li M, Yu H, Yu M, Cui Q.

.

microRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways.

ONCOTARGET.

2017 Mar 7;8(10):16633-16641.

(IF 5.168)

903. Gao R, Chen R, Cao Y, Wang Y, Song K, Zhang Y, Yang J.

.

Emodin suppresses TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells through Notch signaling pathway.

TOXICOL APPL PHARM .

2017 Mar 1;318:1-7.

(IF 3.616)

904. Dai C, Lei L, Li B, Lin Y, Xiao X, Tang S.

.

Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin.

TOXICOL MECH METHOD.

2017 Mar;27(3):165-172.

(IF 2.295)

905. Xu H, Qian M, Zhao B, Wu C, Maskey N, Song H, Li D, Song J, Hua K, Fang L.

.

Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells.

Oncol Rep.

2017 Mar;37(3):1619-1626.

(IF 3.417)

906. Kang Q, Xiang Y, Li D, Liang J, Zhang X, Zhou F, Qiao M, Nie Y, He Y, Cheng J, Dai Y, Li Y.

.

MiR-124-3p attenuates hyperphosphorylation of Tau protein-induced apoptosis via caveolin-1-PI3K/Akt/GSK3β pathway in N2a/APP695swe cells.

ONCOTARGET.

2017 Apr 11;8(15):24314-24326.

(IF 5.168)

907. Xu E, Cao H, Lin L, Liu H.

.

rs10499194 polymorphism in the tumor necrosis factor-α inducible protein 3 (TNFAIP3) gene is associated with type-1 autoimmune hepatitis risk in Chinese Han population.

PLoS One.

2017 Apr 27;12(4):e0176471.

(IF 2.74)

908. Xie H, Wang Z, Zhang L, Lei Q, Zhao A, Wang H, Li Q, Cao Y, Jie Zhang W, Chen Z.

.

Extracellular Vesicle-functionalized Decalcified Bone Matrix Scaffolds with Enhanced Pro-angiogenic and Pro-bone Regeneration Activities.

SCI REP-UK.

2017 Apr 3;7:45622.

(IF 3.998)

909. Xianwu Liu, Bin Quan, Zhilong Tian, Hailin Xi, Gaolei Jia, Hui Wang, Liang Zhang, Ruming Liu, Cheng Ma, Fuzhou Han, Huansong Li, Fukang Yuan.

.

Elevated expression of KLK8 predicts poor prognosis in colorectal cancer.

Biomedicine & Pharmacotherapy.

April 2017, Pages 595-602.

(IF 3.743)

910. Yi Zhu, Minjie Wang, Xu Zhao, Lei Zhang, Yigao Wu, Bangqi Wang, Weilie Hu.

.

Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma.

ONCOTARGET.

2017 Apr 4; 8(14): 22825–22834.

(IF 5.168)

911. Dong Y, Cui P, Li Z, Zhang S.

.

Aging asymmetry: systematic survey of changes in age-related biomarkers in the annual fish Nothobranchius guentheri.

Fish Physiol Biochem.

2017 Apr;43(2):309-319.

(IF 2.242)

912. Yintao Chen, Shasha Yu, Naijin Zhang, Yuan Li, Shuang Chen, Ye Chang, Guozhe Sun, Yingxian Sun.

.

Atorvastatin prevents Angiotensin II induced myocardial hypertrophy in vitro via CCAAT/enhancer-binding protein β.

Biochemical and Biophysical Research Communications.

Volume 486, Issue 2, 29 April 2017, Pages 423-430.

(IF 2.705)

913. Liu H, Huang X, Yu H, Yang X, Zhang X, Hang R, Tang B.

.

A cytocompatible micro/nano-textured surface with Si-doped titania mesoporous arrays fabricated by a one-step anodization.

MAT SCI ENG C-MATER.

2017 Apr 1;73:120-129.

(IF 5.88)

914. Yang Yang, Qin He, Hong Wang, Xinyue Hu, Ying Luo, Guojuan Liang, Shengnan Kuang, Shaoshan Mai, Jie Ma, Xiaoyan Tian, Qi Chen, Junqing Yang.

.

The protection of meloxicam against chronic aluminium overload-induced liver injury in rats.

ONCOTARGET.

2017 Apr 4; 8(14): 23448–23458.

(IF 5.168)

915. Fan X, Zhou S, Zheng M, Deng X, Yi Y, Huang T.

.

MiR-199a-3p enhances breast cancer cell sensitivity to cisplatin by downregulating TFAM (TFAM).

Biomed Pharmacother.

2017 Apr;88:507-514.

(IF 4.545)

916. Carmelina D. Anfuso, Melania Olivieri, Annamaria Fidilio, Gabriella Lupo, Dario Rusciano, Salvatore Pezzino, Caterina Gagliano, Filippo Drago, Claudio Bucolo.

.

Gabapentin Attenuates Ocular Inflammation: In vitro and In vivo Studies.

ORIGINAL RESEARCH ARTICLE.

Front. Pharmacol., 04 April 2017.

917. FangFang, Li H, Qin T, Li M, Ma S.

.

Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway.

Metab Brain Dis.

2017 Apr;32(2):385-393.

(IF 2.726)

918. Zhu WJ, Yang SD, Qu CX, Zhu QL, Chen WL, Li F, Yuan ZQ, Liu Y, You BG, Zhang XN.

.

Low-density lipoprotein-coupled micelles with reduction and pH dual sensitivity for intelligent co-delivery of paclitaxel and siRNA to breast tumor.

INT J NANOMED.

2017 Apr 26;12:3375-3393.

(IF 5.115)

919. Zhang M, Fang X, Wang GS, Ma Y, Jin L, Li XM, Li XP.

.

Ultraviolet B decreases DNA methylation level of CD4+ T cells in patients with systemic lupus erythematosus.

Inflammopharmacology.

2017 Apr;25(2):203-210.

(IF 3.238)

920. Liu X, Wang Y, Cao Z, Dou C, Bai Y, Liu C, Dong S, Fei J.

.

Staphylococcal lipoteichoic acid promotes osteogenic differentiation of mouse mesenchymal stem cells by increasing autophagic activity.

BIOCHEM BIOPH RES CO.

2017 Apr 1;485(2):421-426.

(IF 2.985)

921. Guangyuan Zhao, Cheng Fu, Lu Wang, Lan Zhu, Yutao Yan, Ying Xiang, Fang Zheng, Feili Gong, Song Chen, Gang Chen.

.

Down-regulation of nuclear HMGB1 reduces ischemia-induced HMGB1 translocation and release and protects against liver ischemia-reperfusion injury.

Scientific Reports.

06 April 2017.

(IF 4.011)

922. Li MS, Xin M, Guo CL, Lin GM, Li J, Wu XG.

.

Differential expression of breast cancer-resistance protein, lung resistance protein, and multidrug resistance protein 1 in retinas of streptozotocin-induced diabetic mice.

INT J OPHTHALMOL-CH.

2017 Apr 18;10(4):515-523.

(IF 1.166)

923. Liu S, Liang B, Jia H, Jiao Y, Pang Z, Huang Y.

.

Evaluation of cell death pathways initiated by antitumor drugs melatonin and valproic acid in bladder cancer cells.

FEBS Open Bio.

2017 Apr 27;7(6):798-810.

(IF 2.231)

924. Qu XY, Tao LN, Zhang SX, Sun JM, Niu JQ, Ding YH, Song YQ.

.

The role of Ntcp, Oatp2, Bsep and Mrp2 in liver injury induced by Dioscorea bulbifera L. and Diosbulbin B in mice.

ENVIRON TOXICOL CHEM.

2017 Apr;51:16-22.

(IF 3.152)

925. Li C, Zheng L, Xin Y, Tan Z, Zhang Y, Meng X, Wang Z, Xi T.

.

The competing endogenous RNA network of CYP4Z1 and pseudogene CYP4Z2P exerts an anti-apoptotic function in breast cancer.

FEBS Lett.

2017 Apr;591(7):991-1000.

(IF 3.057)

926. Wang CP, Shi YW, Tang M, Zhang XC, Gu Y, Liang XM, Wang ZW, Ding F.

.

Isoquercetin Ameliorates Cerebral Impairment in Focal Ischemia Through Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Effects in Primary Culture of Rat Hippocampal Neurons and Hippocampal CA1 Region of Rats.

Mol Neurobiol.

2017 Apr;54(3):2126-2142.

(IF 4.5)

927. Chen J, Huang C, Wang J, Zhou H, Lu Y, Lou L, Zheng J, Tian L, Wang X, Cao Z, Zeng Y.

.

Dysbiosis of intestinal microbiota and decrease in paneth cell antimicrobial peptide level during acute necrotizing pancreatitis in rats.

PLoS One.

2017 Apr 25;12(4):e0176583.

(IF 2.74)

928. Yao Y, Wang Y, Zhang Y, Liu C.

.

Klotho ameliorates oxidized low density lipoprotein (ox-LDL)-induced oxidative stress via regulating LOX-1 and PI3K/Akt/eNOS pathways.

Lipids Health Dis.

2017 Apr 13;16(1):77.

(IF 2.906)

929. Xie GL, Zhu L, Zhang YM, Zhang QN, Yu Q.

.

Change in iron metabolism in rats after renal ischemia/reperfusion injury.

PLoS One.

2017 Apr 20;12(4):e0175945.

(IF 2.74)

930. Li W, Zheng M, Wu S, Gao S, Yang M, Li Z, Min Q, Sun W, Chen L, Xiang G, Li H.

.

Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2.

J EXP CLIN CANC RES.

2017 Apr 20;36(1):58.

(IF 7.068)

931. Tian Y, Song Y, Bai W, Ma X, Ren Z.

.

CXCR4 knockdown inhibits the growth and invasion of nasopharyngeal cancer stem cells.

Oncol Lett.

2017 Apr;13(4):2253-2259.

(IF 2.311)

932. Jing YY, Li D, Wu F, Gong LL, Li R.

.

GDF11 does not improve the palmitate induced insulin resistance in C2C12.

EUR REV MED PHARMACO.

2017 Apr;21(8):1795-1802.

(IF 3.024)

933. Dai F, Xuan Y, Jin JJ, Yu S, Long ZW, Cai H, Liu XW, Zhou Y, Wang YN, Chen Z, Huang H.

.

CtBP2 overexpression promotes tumor cell proliferation and invasion in gastric cancer and is associated with poor prognosis.

ONCOTARGET.

2017 Apr 25;8(17):28736-28749.

(IF 5.168)

934. Zou W, Zhou H, Hu J, Zhang L, Tang Q, Wen X, Xiao Z, Wang W.

.

Rhizoma Smilacis Glabrae inhibits pathogen-induced upper genital tract inflammation in rats through suppression of NF-κB pathway.

J Ethnopharmacol.

2017 Apr 18;202:103-113.

(IF 3.69)

935. Li LS, Lu YL, Nie J, Xu YY, Zhang W, Yang WJ, Gong QH, Lu YF, Lu Y, Shi JS.

.

Dendrobium nobile Lindl alkaloid, a novel autophagy inducer, protects against axonal degeneration induced by Aβ25-35 in hippocampus neurons in vitro.

CNS Neurosci Ther.

2017 Apr;23(4):329-340.

(IF 4.074)

936. Zhang L, Gan X, He Y, Zhu Z, Zhu J, Yu H.

.

Drp1-dependent mitochondrial fission mediates osteogenic dysfunction in inflammation through elevated production of reactive oxygen species.

PLoS One.

2017 Apr 7;12(4):e0175262.

(IF 2.74)

937. Zhu TT, Zhang WF, Luo P, Qian ZX, Li F, Zhang Z, Hu CP.

.

LOX-1 promotes right ventricular hypertrophy in hypoxia-exposed rats.

Life Sci.

2017 Apr 1;174:35-42.

(IF 3.647)

938. Xiuyan Wang, Liyu Zheng, Jinming Wu, Binbin Tang, Mengqin Zhang, Debin Zhu, Xianfan Lin.

.

Constitutive androstane receptor activation promotes bilirubin clearance in a murine model of alcoholic liver disease.

Molecular Medicine Reports.

April 4, 2017.

(IF 1.851)

939. Mengqian Li, Yefeng Yuan, Bo Hu, Lei Wu.

.

Study on Lentivirus-Mediated ABCA7 Improves Neurocognitive Function and Related Mechanisms in the C57BL/6 Mouse Model of Alzheimer’s Disease.

Journal of Molecular Neuroscience.

April 2017, Volume 61, Issue 4, pp 489–497.

(IF 2.577)

940. Wang Y, Wang D, Xie G, Yin Y, Zhao E, Tao K, Li R.

.

MicroRNA-152 regulates immune response via targeting B7-H1 in gastric carcinoma.

ONCOTARGET.

2017 Apr 25;8(17):28125-28134.

(IF 5.168)

941. Wang Z, Yuan J, Li L, Yang Y, Xu X, Wang Y.

.

Long non-coding RNA XIST exerts oncogenic functions in human glioma by targeting miR-137.

Am J Transl Res.

2017 Apr 15;9(4):1845-1855. eCollection 2017.

(IF 3.375)

942. Yin K, Zhu R, Wang S, Zhao RC.

.

Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells.

Stem Cells Dev.

2017 May 15;26(10):762-775.

(IF 3.082)

943. Qi-sang Guo, Yu Song, Ke-qin Hua, Shu-jun Gao.

.

Involvement of FAK-ERK2 signaling pathway in CKAP2-induced proliferation and motility in cervical carcinoma cell lines.

Scientific Reports.

18 May 2017.

(IF 4.011)

944. Cheng L, Liu J, Liu Q, Liu Y, Fan L, Wang F, Yu H, Li Y, Bu L, Li X, Wei W, Wang H, Sun G.

.

Exosomes from Melatonin Treated Hepatocellularcarcinoma Cells Alter the Immunosupression Status through STAT3 Pathway in Macrophages.

Int J Biol Sci.

2017 May 16;13(6):723-734.

(IF 4.858)

945. Lin H, Zhao L, Ma X, Wang BC, Deng XY, Cui M, Chen SF, Shao ZW.

.

Drp1 mediates compression-induced programmed necrosis of rat nucleus pulposus cells by promoting mitochondrial translocation of p53 and nuclear translocation of AIF.

BIOCHEM BIOPH RES CO.

2017 May 20;487(1):181-188.

(IF 2.985)

946. Hong Ren, Juan Han, Zhifang Li, Zhiyong Xiong.

.

Stem Cell Factor/Kit Signal Insufficiency Contributes to Hypoxia-Induced Intestinal Motility Dysfunctions in Neonatal Mice.

Digestive Diseases and Sciences.

May 2017, Volume 62, Issue 5, pp 1193–1203.

(IF 2.937)

947. Li J, Guo Y, Duan L, Hu X, Zhang X, Hu J, Huang L, He R, Hu Z, Luo W, Tan T, Huang R, Liao D, Zhu YS, Luo DX.

.

AKR1B10 promotes breast cancer cell migration and invasion via activation of ERK signaling.

ONCOTARGET.

2017 May 16;8(20):33694-33703.

(IF 5.168)

948. Li L, Wang L, Song R, Chen G, Liu Y.

.

Cytochrome P450 2E1 increases the sensitivity of hepatoma cells to vitamin K2.

Int J Oncol.

2017 May;50(5):1832-1838.

(IF 3.899)

949. Pei Wu, Yuchen Li, Shiyi Zhu, Chunlei Wang, Jiaxing Dai, Guang Zhang, Bingjie Zheng, Shancai Xu, Ligang Wang, Tongyu Zhang, PeiQuan Zhou, John H.Zhang, Huaizhang Shi.

.

Mdivi-1 Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats, Possibly via Inhibition of Drp1-Activated Mitochondrial Fission and Oxidative Stress.

Neurochemical Research.

May 2017, Volume 42, Issue 5, pp 1449–1458.

(IF 2.782)

950. Li X, Yang B, Wang L, Chen L, Luo X, Liu L.

.

SPAG6 regulates cell apoptosis through the TRAIL signal pathway in myelodysplastic syndromes.

Oncol Rep.

2017 May;37(5):2839-2846.

(IF 3.417)

951. Liu Bin, Jia Kaiqiao, Yang Yu, Hao Siyuan, Lu Caijie, Xu Fengming, Feng Dehui, Zhu Runzhi.

.

Diosmetin Induces Cell Apoptosis by Regulating CYP1A1/CYP1A2 Due to p53 Activation in HepG2 Cells.

Protein and Peptide Letters.

May 2017, pp. 406-412(7).

(IF 1.168)

952. Jun Lou, Yongli Wang, Zhimin Zhang, Weiqiang Qiu.

.

Activation of MMPs in Macrophages by Mycobacterium tuberculosis via the miR‐223‐BMAL1 Signaling Pathway.

Journal of Cellular Biochemistry.

19 May 2017.

(IF 3.448)

953. Yanjun Sun, Chuan Jiang, Jun Jiang, Lisheng Qiu.

.

Dexmedetomidine protects mice against myocardium ischaemic/reperfusion injury by activating an AMPK/PI3K/Akt/eNOS pathway.

Wiley Online Library.

29 May 2017.

954. Zhan A, Lei B, Wu H, Wen Y, Zheng L, Wang S, Wan X, Wei Z.

.

GGNBP2 Suppresses the Proliferation, Invasion, and Migration of Human Glioma Cells.

Oncol Res.

2017 May 24;25(5):831-842.

(IF 4.949)

955. Hongming Lv, Qinmei Liu, Junfeng Zhou, Guangyun Tan, Xuming Deng, Xinxin Ci.

.

Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death.

Free Radical Biology and Medicine.

Volume 106, May 2017, Pages 38-52.

(IF 5.657)

956. Yong-qiang Ren, Hui-jun Wang, Yong-qing Zhang, Yan-bing Liu.

.

WBP2 modulates G1/S transition in ER+ breast cancer cells and is a direct target of miR-206.

Cancer Chemotherapy and Pharmacology.

May 2017, Volume 79, Issue 5, pp 1003–1011.

(IF 3.008)

957. Xin Chen, Hai-Wen Ding, Hai-Di Li, Hui-Min Huang, Xiao-Feng Li, Yang Yang, Yi-Long Zhang, Xue-Yin Pan, Cheng Huang, Xiao-Ming Meng, Jun Li.

.

Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl4-induced acute liver injury and LPS-treated RAW264.7 cells.

Toxicology Letters.

Volume 274, 15 May 2017, Pages 51-63.

(IF 3.499)

958. Liu Bin, Zhang Miaomiao, Liu Shuna, Ying Jie, Zhang Jingjing, Kurihara Hiroshi, Zheng Weiqiang, He Rong-Rong, Zhu Runzhi.

.

Diosmetin, a Potential p53 Activator, Performs Anticancer Effect by Regulating Cell Cycling and Cell Proliferation in HepG2 Cells.

Protein and Peptide Letters.

Volume 24, Number 5, May 2017, pp. 413-418(6).

(IF 1.168)

959. Zhang JF, Zhang L, Shi LL, Zhao ZH, Xu H, Liang F, Li HB, Zhao Y, Xu X, Yang K, Tian YF.

.

Parthenolide attenuates cerebral ischemia/reperfusion injury via Akt/GSK-3β pathway in PC12 cells.

Biomed Pharmacother.

2017 May;89:1159-1165.

(IF 4.545)

960. Ye M, He Y, Lin H, Yang S, Zhou Y, Zhou L, Zhong J, Lu G, Zheng J, Xue ZX, Cai ZZ.

.

High expression of atonal homolog 8 predicts a poor clinical outcome in patients with colorectal cancer and contributes to tumor progression.

Oncol Rep.

2017 May;37(5):2955-2963.

(IF 3.417)

961. Guo Dong, Shusen Yang, Xuefei Cao, Nannan Yu, Jiangbo Yu, Xiufen Qu.

.

Low shear stress-induced autophagy alleviates cell apoptosis in HUVECs.

Molecular Medicine Reports.

May 2017, Volume 15 Issue 5.

(IF 1.851)

962. Ma K, Ma P, Lu H, Liu S, Cao Q.

.

Fentanyl Suppresses the Survival of CD4+ T Cells Isolated from Human Umbilical Cord Blood through Inhibition of IKKs-mediated NF-κB Activation.

Scand J Immunol.

2017 May;85(5):343-349.

(IF 2.717)

963. Linxi Yu, Xiaoxin Liu, Zihang Yuan, Xiaojiaoyang Li, Hang Yang, Ziqiao Yuan, Lixin Sun, Luyong Zhang, Zhengzhou Jiang.

.

SRT1720 Alleviates ANIT-Induced Cholestasis in a Mouse Model.

ORIGINAL RESEARCH ARTICLE.

11 May 2017.

964. Hui Y, Lu M, Han Y, Zhou H, Liu W, Li L, Jin R.

.

Resveratrol improves mitochondrial function in the remnant kidney from 5/6 nephrectomized rats.

Acta Histochem.

2017 May;119(4):392-399.

(IF 2.107)

965. Zuo Z, Qi F, Yang J, Wang X, Wu Y, Wen Y, Yuan Q, Zou J, Guo K, Yao ZB.

.

Immunization with Bacillus Calmette-Guérin (BCG) alleviates neuroinflammation and cognitive deficits in APP/PS1 mice via the recruitment of inflammation-resolving monocytes to the brain.

Neurobiol Dis.

2017 May;101:27-39.

(IF 5.332)

966. Zhang L, Xiao X, An H, Wang J, Ma Y, Qian YH.

.

Inhibition of CCR7 promotes NF-κB-dependent apoptosis and suppresses epithelial-mesenchymal transition in non-small cell lung cancer.

Oncol Rep.

2017 May;37(5):2913-2919.

(IF 3.417)

967. Chen X, Xu H, Wu N, Liu X, Qiao G, Su S, Tian Y, Yuan R, Li C, Liu X, Lin X.

.

Interaction between granulin A and enolase 1 attenuates the migration and invasion of human hepatoma cells.

ONCOTARGET.

2017 May 2;8(18):30305-30316.

(IF 5.168)

968. Meng Z, Guo L, Li Q.

.

Peptide-Coated Semiconductor Polymer Dots for Stem Cells Labeling and Tracking.

Chemistry.

2017 May 17;23(28):6836-6844.

969. Mo D, Yang D, Xiao X, Sun R, Huang L, Xu J.

.

MiRNA-145 suppresses lung adenocarcinoma cell invasion and migration by targeting N-cadherin.

Biotechnol Lett.

2017 May;39(5):701-710.

(IF 1.977)

970. Chen Y, Zhou CF, Xiao F, Huang HL, Zhang P, Gu HF, Tang XQ.

.

Inhibition of ALDH2 protects PC12 cells against formaldehyde-induced cytotoxicity: involving the protection of hydrogen sulphide.

CLIN EXP PHARMACOL P .

2017 May;44(5):595-601.

(IF 2.092)

971. Deng Z, Jin J, Wang Z, Wang Y, Gao Q, Zhao J.

.

The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening.

INT J NANOMED.

2017 May 10;12:3617-3636.

(IF 5.115)

972. Gong ZY, Yuan ZQ, Dong ZW, Peng YZ.

.

Glutamine with probiotics attenuates intestinal inflammation and oxidative stress in a rat burn injury model through altered iNOS gene aberrant methylation.

Am J Transl Res.

2017 May 15;9(5):2535-2547. eCollection 2017.

(IF 3.375)

973. Zhou J, Wang J, Li W, Wang C, Wu L, Zhang J.

.

Paeoniflorin attenuates the neuroinflammatory response in a rat model of chronic constriction injury.

Mol Med Rep.

2017 May;15(5):3179-3185.

(IF 2.1)

974. Zhao H, Liu F, Jia R, Chang H, Li H, Miao M, Wang H, Yang Z.

.

MiR-570 inhibits cell proliferation and glucose metabolism by targeting IRS1 and IRS2 in human chronic myelogenous leukemia.

Iran J Basic Med Sci.

2017 May;20(5):481-488.

(IF 2.146)

975. Tang M, Zhao Y, Liu N, Chen E, Quan Z, Wu X, Luo C.

.

Overexpression of HepaCAM inhibits bladder cancer cell proliferation and viability through the AKT/FoxO pathway.

J CANCER RES CLIN.

2017 May;143(5):793-805.

(IF 3.656)

976. Su ZQ, Liu YH, Guo HZ, Sun CY, Xie JH, Li YC, Chen JN, Lai XP, Su ZR, Chen HM.

.

Effect-enhancing and toxicity-reducing activity of usnic acid in ascitic tumor-bearing mice treated with bleomycin.

Int Immunopharmacol.

2017 May;46:146-155.

(IF 3.943)

977. CHUNHUA LIN, JIAHUI WANG, YANWEI WANG, PENG ZHU, XIN LIU, NING LI, JUAN LIU, LUXIN YU, WENTING WANG.

.

GRP78 Participates in PCA3-regulated Prostate Cancer Progression.

Dr. George J. Delinasios.

May 29, 2017.

978. Yu C, Zhuang J, Dong L, Cheng K, Weng W.

.

Effect of hierarchical pore structure on ALP expression of MC3T3-E1 cells on bioglass films.

COLLOID SURFACE B.

2017 Aug 1;156:213-220. Epub 2017 May 8.

(IF 4.389)

979. Ye Q, Chen C, Si E, Cai Y, Wang J, Huang W, Li D, Wang Y, Chen X.

.

Mitochondrial Effects of PGC-1alpha Silencing in MPP+ Treated Human SH-SY5Y Neuroblastoma Cells.

Front Mol Neurosci.

2017 May 29;10:164.

(IF 4.057)

980. Chen L, Huang J, Yang L, Zeng XA, Zhang Y, Wang X, Chen M, Li X, Zhang Y, Zhang M.

.

Sleep deprivation accelerates the progression of alzheimer's disease by influencing Aβ-related metabolism.

Neurosci Lett.

2017 May 22;650:146-152.

(IF 2.274)

981. Liu Q, Chen Y, Li Q, Wu L, Wen T.

.

Dcf1 regulates neuropeptide expression and maintains energy balance.

Neurosci Lett.

2017 May 22;650:1-7.

(IF 2.274)

982. Lijun Tao, Fengyan Cao, Gonghao Xu, Haifeng Xie, Mian Zhang, Chaofeng Zhang.

.

Mogroside IIIE Attenuates LPS‐Induced Acute Lung Injury in Mice Partly Through Regulation of the TLR4/MAPK/NF‐κB Axis via AMPK Activation.

phytotherapy research.

17 May 2017.

(IF 3.766)

983. Kun Zhuang, Lingxia Zhang, Xin Zhang, Hailing Tang, Jun Zhang, Yuan Yan, Kun Han, Hanqing Guo.

.

Gastrin induces multidrug resistance via the degradation of p27Kip1 in the gastric carcinoma cell line SGC7901.

International Journal of Oncology.

May 4, 2017.

(IF 3.571)

984. Zhou Q, Zhu S, Guo Y, Lian L, Hu Q, Liu X, Xu F, Zhang N, Kang H.

.

Adenosine A1 Receptors Play an Important Protective Role Against Cognitive Impairment and Long-Term Potentiation Inhibition in a Pentylenetetrazol Mouse Model of Epilepsy.

Mol Neurobiol.

2017 May 10.

(IF 4.5)

985. Zhang X, Liu S, Zhang G, Zhong M, Liu T, Wei M, Wu D, Huang X, Cheng Y, Wu Q, Hu S.

.

Bariatric Surgery Ameliorates Diabetic Cardiac Dysfunction by Inhibiting ER Stress in a Diabetic Rat Model.

Obes Surg.

2017 May;27(5):1324-1334.

(IF 3.412)

986. Yiting Lou, Chenggui Wang, Wenhao Zheng, Qian Tang, Yu Chen, Xiaolei Zhang, Xiaoshan Guo, Jianshun Wang.

.

Salvianolic acid B inhibits IL-1β-induced inflammatory cytokine production in human osteoarthritis chondrocytes and has a protective effect in a mouse osteoarthritis model.

International Immunopharmacology.

Volume 46, May 2017, Pages 31-37.

(IF 3.361)

987. Qin X, Yu S, Zhou L, Shi M, Hu Y, Xu X, Shen B, Liu S, Yan D, Feng J.

.

Cisplatin-resistant lung cancer cell-derived exosomes increase cisplatin resistance of recipient cells in exosomal miR-100-5p-dependent manner.

INT J NANOMED.

2017 May 15;12:3721-3733.

(IF 5.115)

988. Jianshu Gao, Xiaoqiang Liu, Bingjian Wang, Haiyan Xu, Qiang Xia, Tianfei Lu, Fang Wang.

.

Farnesoid X receptor deletion improves cardiac function, structure and remodeling following myocardial infarction in mice.

Molecular Medicine Reports.

May 29, 2017.

(IF 1.851)

989. B Zhou, D Zhang, S M Pei, H Zhang, H C Du, Y P Jin, D G Lin.

.

Establishment of 5-Fluorouracil-resistant canine mammary tumor cell line.

polish journal of veterinary sciences.

13 May 2017.

(IF 0.802)

990. Wang Y, Hu L, Zhang X, Zhao H, Xu H, Wei Y, Jiang H, Xie C, Zhou Y, Zhou F.

.

Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.

J Cancer.

2017 May 12;8(8):1400-1409.

(IF 3.565)

991. Xin Wang, Peng Xiu, Fuhai Wang, Jingtao Zhong, Honglong Wei, Zongzhen Xu, Feng Liu, Jie Li.

.

P18 peptide, a functional fragment of pigment epithelial-derived factor, inhibits angiogenesis in hepatocellular carcinoma via modulating VEGF/VEGFR2 signalling pathway.

Oncology Reports.

June 14, 2017.

(IF 3.041)

992. Chen Y, Gao A, Bai L, Wang Y, Wang X, Zhang X, Huang X, Hang R, Tang B, Chu PK.

.

Antibacterial, osteogenic, and angiogenic activities of SrTiO3 nanotubes embedded with Ag2O nanoparticles.

MAT SCI ENG C-MATER.

2017 Jun 1;75:1049-1058.

(IF 5.88)

993. Xiang Y, Ye W, Huang C, Lou B, Zhang J, Yu D, Huang X, Chen B, Zhou M.

.

Brusatol inhibits growth and induces apoptosis in pancreatic cancer cells via JNK/p38 MAPK/NF-κb/Stat3/Bcl-2 signaling pathway.

BIOCHEM BIOPH RES CO.

2017 Jun 10;487(4):820-826.

(IF 2.985)

994. Zhang JJ, Liu WQ, Peng JJ, Ma QL, Peng J, Luo XJ.

.

miR-21-5p/203a-3p promote ox-LDL-induced endothelial cell senescence through down-regulation of mitochondrial fission protein Drp1.

Mech Ageing Dev.

2017 Jun;164:8-19.

(IF 4.304)

995. Qi-Da Shen, Meng-Meng Yang, Guo-Qiang Xie, Hui-Juan Wang, Lu Zhang, Ling-Yu Qiu, Shi-Gui Wang, Bin Tang.

.

Excess trehalose and glucose affects chitin metabolism in brown planthopper (Nilaparvata lugens).

Journal of Asia-Pacific Entomology.

Volume 20, Issue 2, June 2017, Pages 449-455.

(IF 0.967)

996. Shi S, Zhong D, Xiao Y, Wang B, Wang W, Zhang F, Huang H.

.

Syndecan-1 knockdown inhibits glioma cell proliferation and invasion by deregulating a c-src/FAK-associated signaling pathway.

ONCOTARGET.

2017 Jun 20;8(25):40922-40934.

(IF 5.168)

997. Ma CL, Qiao S, Li YC, Wang XF, Sun RJ, Zhang X, Qian RK, Song SD.

.

TGF-β1 promotes human hepatic carcinoma HepG2 cells invasion by upregulating autophagy.

EUR REV MED PHARMACO.

2017 Jun;21(11):2604-2610.

(IF 3.024)

998. Biying Liu, Haili Zhang, Xiao Tan, Daqian Yang, Zhanjun Lv, Huijie Jiang, Jingjing Lu, Ruiqi Baiyun, Zhigang Zhang.

.

GSPE reduces lead-induced oxidative stress by activating the Nrf2 pathway and suppressing miR153 and GSK-3β in rat kidney.

ONCOTARGET.

2017 Jun 27; 8(26): 42226–42237.

(IF 5.168)

999. Gao Y, Zhou X, Wang H, Liu R, Ye Q, Zhao Q, Ming Z, Dong H.

.

Immunization with recombinant schistosome adenylate kinase 1 partially protects mice against Schistosoma japonicum infection.

Parasitol Res.

2017 Jun;116(6):1665-1674.

(IF 1.641)

1000. Pan CW, Yang SX, Pan ZZ, Zheng B, Wang JZ, Lu GR, Xue ZX, Xu CL.

.

Andrographolide ameliorates d-galactosamine/lipopolysaccharide-induced acute liver injury by activating Nrf2 signaling pathway.

ONCOTARGET.

2017 Jun 20;8(25):41202-41210.

(IF 5.168)

1001. Chen H, Jin Y, Chen H, Liao N, Wang Y, Chen J.

.

MicroRNA-mediated inflammatory responses induced by Cryptococcus neoformans are dependent on the NF-κB pathway in human monocytes.

Int J Mol Med.

2017 Jun;39(6):1525-1532.

(IF 3.098)

1002. Hu C, Lv L, Peng J, Liu D, Wang X, Zhou Y, Huo J.

.

MicroRNA-375 suppresses esophageal cancer cell growth and invasion by repressing metadherin expression.

Oncol Lett.

2017 Jun;13(6):4769-4775.

(IF 2.311)

1003. Dunwei Guo, Chaoyi Wang, Qiang Wang, Zhongpeng Qiao, Hua Tang.

.

Pantoprazole blocks the JAK2/STAT3 pathway to alleviate skeletal muscle wasting in cancer cachexia by inhibiting inflammatory response.

ONCOTARGET.

2017 Jun 13; 8(24): 39640–39648.

(IF 5.168)

1004. Junwei Zhu, Haomiao Li, Jun Ma, Haibo Huang, Jianjun Qin, Yin Li.

.

PTPN9 promotes cell proliferation and invasion in Eca109 cells and is negatively regulated by microRNA-126.

Oncology Letters.

June 6, 2017.

(IF 1.871)

1005. Zhong Y, Fei C, Tang X, Zhan W, Sheng X.

.

A 32 kDa viral attachment protein of lymphocystis disease virus (LCDV) specifically interacts with a 27.8 kDa cellular receptor from flounder (Paralichthys olivaceus).

J Gen Virol.

2017 Jun;98(6):1477-1488.

(IF 3.376)

1006. Lv Y, Chen C, Zhao B, Zhang X.

.

Regulation of matrix stiffness on the epithelial-mesenchymal transition of breast cancer cells under hypoxia environment.

NATURWISSENSCHAFTEN.

2017 Jun;104(5-6):38.

(IF 2.221)

1007. Wang Z, Qiu Z, Gao C, Sun Y, Dong W, Zhang Y, Chen R, Qi Y, Li S, Guo Y, Piao Y, Li S, Piao F.

.

2,5-hexanedione downregulates nerve growth factor and induces neuron apoptosis in the spinal cord of rats via inhibition of the PI3K/Akt signaling pathway.

PLoS One.

2017 Jun 27;12(6):e0179388.

(IF 2.74)

1008. Sun R, Zhu G, Wang J, Tong L, Zhai J.

.

Indirect effects of X-irradiation on proliferation and osteogenic potential of bone marrow mesenchymal stem cells in a local irradiated rat model.

Mol Med Rep.

2017 Jun;15(6):3706-3714.

(IF 2.1)

1009. Huan W, Tianzhu Z, Yu L, Shumin W.

.

Effects of Ergosterol on COPD in Mice via JAK3/STAT3/NF-κB Pathway.

Inflammation.

2017 Jun;40(3):884-893.

(IF 3.212)

1010. Li M, Wu X, Liu N, Li X, Meng F, Song S.

.

Silencing of ATF2 inhibits growth of pancreatic cancer cells and enhances sensitivity to chemotherapy.

Cell Biol Int.

2017 Jun;41(6):599-610.

(IF 2.571)

1011. Wu J, Hu G, Dong Y, Ma R, Yu Z, Jiang S, Han Y, Yu K, Zhang S.

.

Matrine induces Akt/mTOR signalling inhibition-mediated autophagy and apoptosis in acute myeloid leukaemia cells.

J Cell Mol Med.

2017 Jun;21(6):1171-1181.

(IF 4.486)

1012. Zhang C, Zhou G, Cai C, Li J, Chen F, Xie L, Wang W, Zhang Y, Lai X, Ma L.

.

Human umbilical cord mesenchymal stem cells alleviate acute myocarditis by modulating endoplasmic reticulum stress and extracellular signal regulated 1/2-mediated apoptosis.

Mol Med Rep.

2017 Jun;15(6):3515-3520.

(IF 2.1)

1013. Du L, Chen X, Duan Z, Liu C, Zeng R, Chen Q, Li M.

.

MiR-146a negatively regulates dectin-1-induced inflammatory responses.

ONCOTARGET.

2017 Jun 6;8(23):37355-37366.

(IF 5.168)

1014. Qin X, Yu S, Xu X, Shen B, Feng J.

.

Comparative analysis of microRNA expression profiles between A549, A549/DDP and their respective exosomes.

ONCOTARGET.

2017 Jun 27;8(26):42125-42135.

(IF 5.168)

1015. Yu-Zhen Feng, Qing-Yan Zhang, Mei-Ting Fu, Zhen-Fei Zhang, Min Wei, Jue-Yu Zhou, Rong Shi.

.

Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer.

Oncology Reports.

June 2, 2017.

(IF 3.041)

1016. Qu L, Li J, Zhao Z, Jiang H, Zhang Q.

.

Differential Expression of miR-202 and Validation of Predicted Target Genes in the Skin Tissue of C57BL/6 Black Mice and BALB/c White Mice.

DNA Cell Biol.

2017 Jun;36(6):443-450.

(IF 3.191)

1017. Yongming Li, Xianda Meng, Wenguang Wang, Fu Liu, Zhiru Hao, Yang Yang, Jinbo Zhao, Wensi Yin, Lijuan Xu, Ruiping Zhao, Jiang Hu.

.

Cardioprotective Effects of SIRT6 in a Mouse Model of Transverse Aortic Constriction-Induced Heart Failure.

ORIGINAL RESEARCH ARTICLE.

13 June 2017.

1018. Lijun Tao, Juan Cao, Wencheng Wei, Haifeng Xie, Mian Zhang, Chaofeng Zhang.

.

Protective role of rhapontin in experimental pulmonary fibrosis in vitro and in vivo.

International Immunopharmacology.

June 2017, Pages 38-46.

(IF 3.361)

1019. Zhao J, Xu T, Wang F, Cai W, Chen L.

.

miR-493-5p suppresses hepatocellular carcinoma cell proliferation through targeting GP73.

Biomed Pharmacother.

2017 Jun;90:744-751.

(IF 4.545)

1020. Jin-ming Zhang, Xing-he Wang, Li-hong Hao, He Wang, Xiu-ying Zhang, Ishfaq Muhammad, Yue Qi, Guang-liang Li, Xiao-qi Sun.

.

Nrf2 is crucial for the down-regulation of Cyp7a1 induced by arachidonic acid in Hepg2 cells.

Environmental Toxicology and Pharmacology.

June 2017, Pages 21-26.

(IF 3.061)

1021. Zhang H, Ju B, Zhang X, Zhu Y, Nie Y, Xu Y, Lei Q.

.

Magnolol Attenuates Concanavalin A-induced Hepatic Fibrosis, Inhibits CD4+ T Helper 17 (Th17) Cell Differentiation and Suppresses Hepatic Stellate Cell Activation: Blockade of Smad3/Smad4 Signalling.

BASIC CLIN PHARMACOL.

2017 Jun;120(6):560-570.

(IF 2.651)

1022. Pu SY, Yu Q, Wu H, Jiang JJ, Chen XQ, He YH, Kong QP.

.

ERCC6L, a DNA helicase, is involved in cell proliferation and associated with survival and progress in breast and kidney cancers.

ONCOTARGET.

2017 Jun 27;8(26):42116-42124.

(IF 5.168)

1023. Shan Zhang, Wan-Ling Yin, Xin Zhang, Xiao-Yu Zhang.

.

MicroRNA-455 is downregulated in gastric cancer and inhibits cell proliferation, migration and invasion via targeting insulin-like growth factor 1 receptor.

MOL MED REP.

July 14, 2017.

(IF 2.1)

1024. Jingjing Zhang, Lu Liu, Sai Han, Yi Li, Qiuhong Qian, Qianqian Zhang, Hui Zhang, Ziyan Yang, Youzhong Zhang.

.

B7-H3 is related to tumor progression in ovarian cancer.

Oncology Reports.

July 31, 2017.

(IF 3.041)

1025. Xinchao Deng, Congzhe Hou, Zhen Liang, Huali Wang, Lin Zhu, Hui Xu.

.

miR-202 Suppresses Cell Proliferation by Targeting FOXR2 in Endometrial Adenocarcinoma.

Disease Markers.

30 July 2017.

(IF 2.761)

1026. Ngabu Malobi, Lan He, Long Yu, Pei He, Junwei He, Yali Sun, Yuan Huang, Junlong Zhao.

.

Molecular Cloning and Characterization of Babesia orientalis Rhoptry Neck 2 BoRON2 Protein.

IRAN J PARASITOL.

9 July 2017.

(IF 1.018)

1027. Liu F, Bai C, Guo Z.

.

The prognostic value of osteopontin in limited-stage small cell lung cancer patients and its mechanism.

ONCOTARGET.

2017 Jul 26;8(41):70084-70096.

(IF 5.168)

1028. Liu Y, Liu B, Zhang Y, Peng Y, Huang C, Wang N, Jiang J, Wang Q, Chang J.

.

Intestinal absorption mechanisms of 2'-deoxy-2'-β-fluoro-4'-azidocytidine, a cytidine analog for AIDS treatment, and its interaction with P-glycoprotein, multidrug resistance-associated protein 2 and breast cancer resistance protein.

Eur J Pharm Sci.

2017 Jul 15;105:150-158.

(IF 3.616)

1029. Zhongcheng Ke, Gang Wang, Lei Yang, Huihui Qiu, Hao Wu, Mei Du, Juan Chen, Jie Song, Xiaobin Jia, Liang Feng.

.

Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway.

Journal of Ethnopharmacology.

Volume 206, 12 July 2017, Pages 160-169.

(IF 3.414)

1030. Su Y, Yu QH, Wang XY, Yu LP, Wang ZF, Cao YC, Li JD.

.

JMJD2A promotes the Warburg effect and nasopharyngeal carcinoma progression by transactivating LDHA expression.

BMC Cancer.

2017 Jul 11;17(1):477.

(IF 3.15)

1031. Zhiguo Chen, Rujian Zhu, Jiayi Zheng, Chen Chen, Chi Huang, Junjie Ma, Chen Xu, Wei Zhai, Junhua Zheng.

.

Cryptotanshinone inhibits proliferation yet induces apoptosis by suppressing STAT3 signals in renal cell carcinoma.

ONCOTARGET.

2017 Jul 25; 8(30): 50023–50033.

(IF 5.168)

1032. Zhao C, Li Y, Chen G, Wang F, Shen Z, Zhou R.

.

Overexpression of miR-15b-5p promotes gastric cancer metastasis by regulating PAQR3.

Oncol Rep.

2017 Jul;38(1):352-358.

(IF 3.417)

1033. Wu J, Huang J, Wang W, Xu J, Yin M, Cheng N, Yin J.

.

Long non-coding RNA Fer-1-like protein 4 acts as a tumor suppressor via miR-106a-5p and predicts good prognosis in hepatocellular carcinoma.

Cancer Biomark.

2017 Jul 19;20(1):55-65.

(IF 3.436)

1034. Zhao G, Xu D, Yuan Z, Jiang Z, Zhou W, Li Z, Yin M, Zhou Z, Zhang L, Wang T.

.

8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity.

Toxicology.

2017 Jul 1;386:40-48.

(IF 4.099)

1035. Sun X, Wei Q, Cheng J, Bian Y, Tian C, Hu Y, Li H.

.

Enhanced Stim1 expression is associated with acquired chemo-resistance of cisplatin in osteosarcoma cells.

Hum Cell.

2017 Jul;30(3):216-225.

(IF 3.463)

1036. Wang H, Zhai N, Chen Y, Xu H, Huang K.

.

Cadmium induces Ca2+ mediated, calpain-1/caspase-3-dependent apoptosis in primary cultured rat proximal tubular cells.

J Inorg Biochem.

2017 Jul;172:16-22.

(IF 3.212)

1037. Si-Jie Li, Chun-Shui Liu, Hai-Jun Li, Yan Li, Lei Zhou, Jin-Cheng Li, Yi-Chang Chen, Tian-Qi Su, De-Hai Yu.

.

A novel engineered interferon-α hybrid molecule increases anticancer efficacy of doxorubicin in breast cancer chemotherapy.

International Journal of Oncology.

July 3, 2017.

(IF 3.571)

1038. Kaige Peng, Likui Yang, Jian Wang, Feng Ye, Guorong Dan, Yuanpeng Zhao, Ying Cai, Zhihong Cui, Lin Ao, Jinyi Liu, Zhongmin Zou, Yan Sai, Jia Cao.

.

The Interaction of Mitochondrial Biogenesis and Fission/Fusion Mediated by PGC-1α Regulates Rotenone-Induced Dopaminergic Neurotoxicity.

Molecular Neurobiology.

July 2017, Volume 54, Issue 5, pp 3783–3797.

(IF 4.586)

1039. Huang Q, Liu X, Wu Y, Liao Y, Huang Y, Wei X, Ma M.

.

P38 MAPK pathway mediates cognitive damage in pentylenetetrazole-induced epilepsy via apoptosis cascade.

Epilepsy Res.

2017 Jul;133:89-92.

(IF 2.208)

1040. Zhang CX, Wang T, Ma JF, Liu Y, Zhou ZG, Wang DC.

.

Protective effect of CDDO-ethyl amide against high-glucose-induced oxidative injury via the Nrf2/HO-1 pathway.

Spine J.

2017 Jul;17(7):1017-1025.

(IF 3.191)

1041. Qirong Wen, Yan Liu, Huabing Lyu, Xiaying Xu, Qingxia Wu, Ni Liu, Qi Yin, Juan Li, Xiujie Sheng.

.

Long Noncoding RNA GAS5, Which Acts as a Tumor Suppressor via microRNA 21, Regulates Cisplatin Resistance Expression in Cervical Cancer.

Int J Gynecol Cancer.

2017 Jul; 27(6): 1096–1108.

(IF 2.095)

1042. Gao Q, Wang K, Chen K, Liang L, Zheng Y, Zhang Y, Xiang J, Tang N.

.

HBx protein-mediated ATOH1 downregulation suppresses ARID2 expression and promotes hepatocellular carcinoma.

Cancer Sci.

2017 Jul;108(7):1328-1337.

(IF 4.966)

1043. Liu Z, Zeng W, Wang S, Zhao X, Guo Y, Yu P, Yin X, Liu C, Huang T.

.

A potential role for the Hippo pathway protein, YAP, in controlling proliferation, cell cycle progression, and autophagy in BCPAP and KI thyroid papillary carcinoma cells.

Am J Transl Res.

2017 Jul 15;9(7):3212-3223. eCollection 2017.

(IF 3.375)

1044. Liu L, Cai X, Liu E, Tian X, Tian C.

.

MicroRNA-18a promotes proliferation and metastasis in hepatocellular carcinoma via targeting KLF4.

ONCOTARGET.

2017 Jul 17;8(40):68263-68269.

(IF 5.168)

1045. He R, Lu Y, Ren J, Wang Z, Huang J, Zhu L, Wang K.

.

Decreased fibrous encapsulation and enhanced osseointegration in vitro by decorin-modified titanium surface.

COLLOID SURFACE B.

2017 Jul 1;155:17-24.

(IF 4.389)

1046. Pan L, Zhang Y, Zhao W, Zhou X, Wang C, Deng F.

.

The cardiac glycoside oleandrin induces apoptosis in human colon cancer cells via the mitochondrial pathway.

CANCER CHEMOTH PHARM.

2017 Jul;80(1):91-100.

(IF 2.967)

1047. Li D, Wang H, Song H, Xu H, Zhao B, Wu C, Hu J, Wu T, Xie D, Zhao J, Shen Q, Fang L.

.

The microRNAs miR-200b-3p and miR-429-5p target the LIMK1/CFL1 pathway to inhibit growth and motility of breast cancer cells.

ONCOTARGET.

2017 Jul 12;8(49):85276-85289.

(IF 5.168)

1048. Zhang D, Wu H, Zhang X, Ding X, Huang M, Geng M, Li H, Xie Z.

.

Phosphoglycerate Mutase 1 Predicts the Poor Prognosis of Oral Squamous Cell Carcinoma and is Associated with Cell Migration.

J Cancer.

2017 Jul 5;8(11):1943-1951.

(IF 3.565)

1049. Wang Y, Zhou Q, Wu B, Zhou H, Zhang X, Jiang W, Wang L, Wang A.

.

Propofol induces excessive vasodilation of aortic rings by inhibiting protein kinase Cβ2 and θ in spontaneously hypertensive rats.

BRIT J PHARMACOL.

2017 Jul;174(13):1984-2000.

(IF 7.73)

1050. Zheng X, Xie Z, Wang S, Lin P.

.

Determination of the protein expression profiles of Propsilocerus akamusi (Tokunaga) Malpighian tubules response to cadmium stress by iTRAQ coupled LC-MS/MS.

J Proteomics.

2017 Jul 5;164:85-93.

(IF 3.509)

1051. Yang X, Song Z, Chen L, Wang R, Huang S, Qin W, Guo J, Lin Z.

.

Role of transient receptor potential channel 6 in the odontogenic differentiation of human dental pulp cells.

Exp Ther Med.

2017 Jul;14(1):73-78.

(IF 1.785)

1052. Yang X, Tang S, Dai C, Li D, Zhang S, Deng S, Zhou Y, Xiao X.

.

Quinocetone induces mitochondrial apoptosis in HepG2 cells through ROS-dependent promotion of VDAC1 oligomerization and suppression of Wnt1/β-catenin signaling pathway.

Food Chem Toxicol.

2017 Jul;105:161-176.

(IF 4.679)

1053. Hui Z, Li R, Chen L.

.

The impact of exposure to environmental contaminant on hepatocellular lipid metabolism.

Gene.

2017 Jul 30;622:67-71.

(IF 2.984)

1054. Xia Q, Zhao Y, Wang J, Qiao W, Zhang D, Yin H, Xu D, Chen F.

.

Proteomic analysis of cell cycle arrest and differentiation induction caused by ATPR, a derivative of all-trans retinoic acid, in human gastric cancer SGC-7901 cells.

PROTEOM CLIN APPL.

2017 Jul;11(7-8).

(IF 2.489)

1055. Yong Fu, Junting Ma, Xiafei Shi, Xiang-Yun Song, Yaping Yang, Shuke Xiao, Jiahuang Li, Wei-Jin Gu, Zhen Huang, Junfeng Zhang, Jiangning Chen.

.

A novel pyrazole-containing indolizine derivative suppresses NF-κB activation and protects against TNBS-induced colitis via a PPAR-γ-dependent pathway.

Biochemical Pharmacology.

Volume 135, 1 July 2017, Pages 126-138.

(IF 4.825)

1056. Liu J, Jiang X, Zhang Q, Lin S, Zhu J, Zhang Y, Du J, Hu X, Meng W, Zhao Q.

.

Neuroprotective effects of Kukoamine A against cerebral ischemia via antioxidant and inactivation of apoptosis pathway.

Neurochem Int.

2017 Jul;107:191-197.

(IF 3.881)

1057. Zhang YQ, Fan YG, Dang YL, Liu YL, Liu H, Li LH.

.

Down-regulation of protein kinase C alpha/ezrin signals in light-induced phagocytic crisis of retinal pigment epithelium cells.

INT J OPHTHALMOL-CH.

2017 Jul 18;10(7):1040-1045.

(IF 1.166)

1058. Liu Y, Song M, Zhu G, Xi X, Li K, Wu C, Huang L.

.

Corynoline attenuates LPS-induced acute lung injury in mice by activating Nrf2.

Int Immunopharmacol.

2017 Jul;48:96-101.

(IF 3.943)

1059. Bo Zhou, Gongping Wang, Shegan Gao, Ye Chen, Canhui Jin, Zengfang Wang, Yantong Yang, Zhikun Ma, Wei Zhang, Xiaoshan Feng.

.

Expression of ERO1L in gastric cancer and its association with patient prognosis.

Experimental and Therapeutic Medicine.

July 11, 2017.

(IF 1.448)

1060. Honglin Ding, Ning Li, Xiaoning He, Bing Liu, Liming Dong, Yili Liu.

.

Treatment of obesity-associated overactive bladder by the phosphodiesterase type-4 inhibitor roflumilast.

International Urology and Nephrology.

29 July 2017.

(IF 1.596)

1061. Huang Y, Qin J, Sun D, Jiang H, Zheng L, He Y, Gui L, Qian B, Zhang C, Luo M.

.

Inhibition of soluble epoxide hydrolase reduces portal pressure by protecting mesenteric artery myogenic responses in cirrhotic rats.

PROSTAG OTH LIPID M.

2017 Jul;131:17-24.

(IF 2.283)

1062. Yu-hu Jiao, Min Dou, Guang Wang, Hong-ye Li, Jie-sheng Liu, Xuesong Yang, Wei-dong Yang.

.

Exposure of okadaic acid alters the angiogenesis in developing chick embryos.

Toxicon.

Volume 133, July 2017, Pages 74-81.

(IF 2.201)

1063. Zhang Y, Zhao L, Wu Z, Chen X, Ma T.

.

Galantamine alleviates senescence of U87 cells induced by beta-amyloid through decreasing ROS production.

Neurosci Lett.

2017 Jul 13;653:183-188.

(IF 2.274)

1064. Liu Y, Zou J, Li B, Wang Y, Wang D, Hao Y, Ke X, Li X.

.

RUNX3 modulates hypoxia-induced endothelial-to-mesenchymal transition of human cardiac microvascular endothelial cells.

Int J Mol Med.

2017 Jul;40(1):65-74.

(IF 3.098)

1065. Deng W, Zhu Y, Lin J, Zheng L, Zhang C, Luo M.

.

Inhibition of soluble epoxide hydrolase lowers portal hypertension in cirrhotic rats by ameliorating endothelial dysfunction and liver fibrosis.

PROSTAG OTH LIPID M.

2017 Jul;131:67-74.

(IF 2.283)

1066. Xie X, Guo A, Wu T, Hu Q, Huang L, Yao C, Zhao B, Zhang W, Chi B, Lu P, Zhao Z, Fu Z.

.

Preventive effect of L-carnitine on the disorder of lipid metabolism and circadian clock of mice subjected to chronic jet-lag.

Physiol Res.

2017 Nov 24;66(5):801-810. Epub 2017 Jul 18.

(IF 1.655)

1067. Luo Q, Cui H, Deng H, Kuang P, Liu H, Lu Y, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L.

.

Sodium fluoride induces renal inflammatory responses by activating NF-κB signaling pathway and reducing anti-inflammatory cytokine expression in mice.

ONCOTARGET.

2017 Jul 5;8(46):80192-80207.

(IF 5.168)

1068. Cao JY, Yin HS, Li HS, Yu XQ, Han X.

.

Interleukin-27 augments the inhibitory effects of sorafenib on bladder cancer cells.

Braz J Med Biol Res.

2017 Jul 20;50(8):e6207.

(IF 2.023)

1069. Wang M, Zhang W, Xu S, Peng L, Wang Z, Liu H, Fang Q, Deng T, Men X, Lou J.

.

TRB3 mediates advanced glycation end product-induced apoptosis of pancreatic β-cells through the protein kinase C β pathway.

Int J Mol Med.

2017 Jul;40(1):130-136.

(IF 3.098)

1070. Xu Y, Deng N, Wang X, Chen Y, Li G, Fan H.

.

RKTG overexpression inhibits proliferation and induces apoptosis of human leukemia cells via suppression of the ERK and PI3K/AKT signaling pathways.

Oncol Lett.

2017 Jul;14(1):965-970.

(IF 2.311)

1071. Jianrui Lv, Junbin Tian, Guoxi Zheng, Jing Zhao.

.

Sirtuin7 is involved in protecting neurons against oxygen‐glucose deprivation and reoxygenation‐induced injury through regulation of the p53 signaling pathway.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY.

04 July 2017.

(IF 2.965)

1072. Ying Zhang, Hui Sun, Jiaojiao Li, Qianyu Rong, Xiaofei Ji, Boqing Li.

.

The leukocyte-associated immunoglobulin (Ig)–like receptor-1 modulating cell apoptosis and inflammatory cytokines secretion in THP-1 cells after Helicobacter pylori infection.

Microbial Pathogenesis.

Volume 109, August 2017, Pages 292-299.

(IF 2.581)

1073. Cui Q, Fu J, Hu Y, Li Y, Yang B, Li L, Sun J, Chen C, Sun G, Xu Y, Zhang Q, Pi J.

.

Deficiency of long isoforms of Nfe2l1 sensitizes MIN6 pancreatic β cells to arsenite-induced cytotoxicity.

TOXICOL APPL PHARM .

2017 Aug 15;329:67-74.

(IF 3.616)

1074. Wu D, Xie F, Xiao L, Feng F, Huang S, He L, Liu M, Zhou Q, Li L, Chen L.

.

Caveolin-1-Autophagy Pathway Mediated Cardiomyocyte Hypertrophy Induced by Apelin-13.

DNA Cell Biol.

2017 Aug;36(8):611-618.

(IF 3.191)

1075. Ding YY, Li ZQ, Cheng XR, Ran YM, Wu SJ, Shi Y, Le G.

.

Dityrosine administration induces dysfunction of insulin secretion accompanied by diminished thyroid hormones T3 function in pancreas of mice.

Amino Acids.

2017 Aug;49(8):1401-1414.

(IF 3.063)

1076. Hui Xue, Juan Dong, Huijun Xu, Xin Huang, Huangguan Dai, Cuifang Hao.

.

Tiaogeng Yijing decoction improves the pregnancy outcomes of patients with poor ovarian response undergoing in vitro fertilization-embryo transfer.

EXP THER MED.

August 16, 2017, Pages: 3935-3941.

(IF 1.785)

1077. Shengjie Li, Fengxia Yang, Meiyan Wang, Wenjun Cao, Zhen Yang.

.

miR-378 functions as an onco-miRNA by targeting the ST7L/Wnt/β-catenin pathway in cervical cancer.

International Journal of Molecular Medicine.

August 30, 2017.

(IF 2.928)

1078. Gao L, Chen B, Li J, Yang F, Cen X, Liao Z, Long X.

.

Wnt/β-catenin signaling pathway inhibits the proliferation and apoptosis of U87 glioma cells via different mechanisms.

PLoS One.

2017 Aug 24;12(8):e0181346.

(IF 2.74)

1079. Qina He, Lin Zong, Yulong Sun, Vijayalaxmi, Thomas J.Prihoda, Jian Tong, Yi Cao.

.

Adaptive response in mouse bone marrow stromal cells exposed to 900 MHz radiofrequency fields: Impact of poly (ADP-ribose) polymerase (PARP).

MUTAT RES-GEN TOX EN.

August 2017, Pages 19-25.

(IF 2.506)

1080. Yongmei Yang, Jie Du, Fen Liu, Xiaoyan Wang, Xiaohui Li, Yuanjian Li.

.

Role of caspase-3/E-cadherin in helicobacter pylori-induced apoptosis of gastric epithelial cells.

ONCOTARGET.

2017 Aug 29; 8(35): 59204–59216.

(IF 5.168)

1081. Lu MD, Li LY, Li PH, You T, Wang FH, Sun WJ, Zheng ZQ.

.

Gossypol induces cell death by activating apoptosis and autophagy in HT-29 cells.

Mol Med Rep.

2017 Aug;16(2):2128-2132.

(IF 2.1)

1082. Min Gao, Kai-Min Guo, Ying-Mei Wei, Ming-Ming Ma, Jia-Rong Cai, Ting-Ting Xia, Qing-Jian Ye.

.

Aspirin inhibits the proliferation of human uterine leiomyoma cells by downregulation of K-Ras-p110α interaction.

Oncology Reports.

August 22, 2017.

(IF 3.041)

1083. Wenxi Wang, Anna Shao, Shisen Feng, Min Ding, Gan Luo.

.

Physicochemical characterization and gastrointestinal adhesion of S-layer proteins-coating liposomes.

International Journal of Pharmaceutics.

30 August 2017, Pages 227-237.

(IF 4.213)

1084. Jing Gan, Qianyun Cai, Yi Qu, Fengyan Zhao, Chaomin Wan, Rong Luo, Dezhi Mu.

.

miR-96 attenuates status epilepticus-induced brain injury by directly targeting Atg7 and Atg16L1.

scientific reports.

31 August 2017.

(IF 4.011)

1085. Hu LW, Wang X, Jiang XQ, Xu LQ, Pan HY.

.

In vivo and in vitro study of osteogenic potency of endothelin-1 on bone marrow-derived mesenchymal stem cells.

Exp Cell Res.

2017 Aug 1;357(1):25-32.

(IF 3.383)

1086. Tian-Tian Zhu, Wei-Fang Zhang, Ping Luo, Fang He, Xiao-Yue Ge, Zheng Zhang, Chang-Ping Hu.

.

Epigallocatechin-3-gallate ameliorates hypoxia-induced pulmonary vascular remodeling by promoting mitofusin-2-mediated mitochondrial fusion.

European Journal of Pharmacology.

Volume 809, 15 August 2017, Pages 42-51.

(IF 3.17)

1087. Feng F, Ren Q, Wu S, Saeed M, Sun C.

.

Hoxa5 increases mitochondrial apoptosis by inhibiting Akt/mTORC1/S6K1 pathway in mice white adipocytes.

ONCOTARGET.

2017 Aug 24;8(56):95332-95345.

(IF 5.168)

1088. Changyu Sun, Zhihao Zhang, Ping He, Yan Zhou, Xuhua Xie.

.

Involvement of PI3K/Akt pathway in the inhibition of hepatocarcinoma cell invasion and metastasis induced by SASH1 through downregulating Shh-Gli1 signaling.

INT J BIOCHEM CELL B.

Volume 89, August 2017, Pages 95-100.

(IF 3.673)

1089. Liu H, Peng H, Chen S, Liu Y, Xiang H, Chen R, Chen W, Zhao S, Chen P, Lu H.

.

S1PR2 antagonist protects endothelial cells against high glucose-induced mitochondrial apoptosis through the Akt/GSK-3β signaling pathway.

BIOCHEM BIOPH RES CO.

2017 Aug 26;490(3):1119-1124.

(IF 2.985)

1090. Lai Y, He S, Ma L, Lin H, Ren B, Ma J, Zhu X, Zhuang S.

.

HOTAIR functions as a competing endogenous RNA to regulate PTEN expression by inhibiting miR-19 in cardiac hypertrophy.

Mol Cell Biochem.

2017 Aug;432(1-2):179-187.

(IF 2.795)

1091. Sun J, Gao X, Meng D, Xu Y, Wang X, Gu X, Guo M, Shao X, Yan H, Jiang C, Zheng Y.

.

Antagomirs Targeting MiroRNA-134 Attenuates Epilepsy in Rats through Regulation of Oxidative Stress, Mitochondrial Functions and Autophagy.

Front Pharmacol.

2017 Aug 8;8:524.

(IF 4.225)

1092. Yongfa Zheng, Liang Liu, Cong Chen, Pingpo Ming, Qin Huang, Changhu Li, Dedong Cao, Ximing Xu, Wei Ge.

.

The extracellular vesicles secreted by lung cancer cells in radiation therapy promote endothelial cell angiogenesis by transferring miR-23a.

PEERJ.

August 25, 2017.

(IF 2.379)

1093. Yang Y, Jin G, Liu H, Liu K, Zhao J, Chen X, Wang D, Bai R, Li X, Jang Y, Lu J, Xing Y, Dong Z.

.

Metformin inhibits esophageal squamous cell carcinoma-induced angiogenesis by suppressing JAK/STAT3 signaling pathway.

ONCOTARGET.

2017 Aug 18;8(43):74673-74687.

(IF 5.168)

1094. Jiang W, Chen Y, Li B, Gao S.

.

DBA-induced caspase-3-dependent apoptosis occurs through mitochondrial translocation of cyt-c in the rat hippocampus.

Mol Biosyst.

2017 Aug 22;13(9):1863-1873.

(IF 3.336)

1095. Gao P, Qiao X, Sun H, Huang Y, Lin J, Li L, Wang X, Li C.

.

Activated spleen tyrosine kinase promotes malignant progression of oral squamous cell carcinoma via mTOR/S6 signaling pathway in an ERK1/2-independent manner.

ONCOTARGET.

2017 Aug 3;8(48):83900-83912.

(IF 5.168)

1096. Quan Chen, Guanghua Luo, Xiaoying Zhang.

.

MiR-148a modulates HLA-G expression and influences tumor apoptosis in esophageal squamous cell carcinoma.

Experimental and Therapeutic Medicine.

August 28, 2017.

(IF 1.448)

1097. Leiming Zhang, Maojing Zhu, Minmin Li, Yuan Du, Sijin Duan, Yanan Huang, Yongying Lu, Jianqiao Zhang, Tian Wang, Fenghua Fu.

.

Ginsenoside Rg1 attenuates adjuvant-induced arthritis in rats via modulation of PPAR-γ/NF-κB signal pathway.

ONCOTARGET.

2017 Aug 15; 8(33): 55384–55393.

(IF 5.168)

1098. Cai B, Xiao Y, Li Y, Zheng S.

.

CMTM5 inhibits renal cancer cell growth through inducing cell-cycle arrest and apoptosis.

Oncol Lett.

2017 Aug;14(2):1536-1542.

(IF 2.311)

1099. Wang X, Chen J, Wang H, Yu H, Wang C, You J, Wang P, Feng C, Xu G, Wu X, Zhao R, Zhang G.

.

Memantine Can Reduce Ethanol-Induced Caspase-3 Activity and Apoptosis in H4 Cells by Decreasing Intracellular Calcium.

J Mol Neurosci.

2017 Aug;62(3-4):402-411.

(IF 2.678)

1100. Ling F, Tang Y, Li M, Li QS, Li X, Yang L, Zhao W, Jin CC, Zeng Z, Liu C, Wu CF, Chen WW, Lin X, Wang YL, Threadgill MD.

.

Mono-ADP-ribosylation of histone 3 at arginine-117 promotes proliferation through its interaction with P300.

ONCOTARGET.

2017 Aug 18;8(42):72773-72787.

(IF 5.168)

1101. Ding Y, Gu Z, Wang Y, Wang S, Chen H, Zhang H, Chen W, Chen YQ.

.

Clove extract functions as a natural fatty acid synthesis inhibitor and prevents obesity in a mouse model.

Food Funct.

2017 Aug 1;8(8):2847-2856.

(IF 4.171)

1102. Zhang GM, Deng MT, Lei ZH, Wan YJ, Nie HT, Wang ZY, Fan YX, Wang F, Zhang YL.

.

Effects of NRF1 on steroidogenesis and apoptosis in goat luteinized granulosa cells.

Reproduction.

2017 Aug;154(2):111-122.

(IF 3.206)

1103. Shen CJ, Cheng YM, Wang CL.

.

LncRNA PVT1 epigenetically silences miR-195 and modulates EMT and chemoresistance in cervical cancer cells.

J Drug Target.

2017 Aug;25(7):637-644.

(IF 3.38)

1104. Chen B, Na F, Yang H, Li R, Li M, Sun X, Hu B, Huang G, Lan J, Xu H, Tong R, Mo X, Xue J, Lu Y.

.

Ethyl pyruvate alleviates radiation-induced lung injury in mice.

Biomed Pharmacother.

2017 Aug;92:468-478.

(IF 4.545)

1105. Lin J, Wang C, Zhang L, Wang T, Zhang J, Liang W, Li C, Qian G, Ouyang Y, Guo K, Zhang Y.

.

Rab5 Enhances Classical Swine Fever Virus Proliferation and Interacts with Viral NS4B Protein to Facilitate Formation of NS4B Related Complex.

Front Microbiol.

2017 Aug 8;8:1468.

(IF 4.235)

1106. Sun L, Yuan Q, Xu T, Yao L, Feng J, Ma J, Wang L, Lu C, Wang D.

.

Pioglitazone Improves Mitochondrial Function in the Remnant Kidney and Protects against Renal Fibrosis in 5/6 Nephrectomized Rats.

Front Pharmacol.

2017 Aug 15;8:545.

(IF 4.225)

1107. Shen Y, Cao R, Liu W, Zhou Y, Wu Y, Tan J, Jin M, Zhong J, Zhang Q, Liu J, Zu X.

.

Negative feedback loop between ZBTB7A and TGF-β in breast cancer.

Oncol Lett.

2017 Aug;14(2):1403-1410.

(IF 2.311)

1108. Cai M, Guo Y, Wang S, Wei H, Sun S, Zhao G, Dong H.

.

Tanshinone IIA Elicits Neuroprotective Effect Through Activating the Nuclear Factor Erythroid 2-Related Factor-Dependent Antioxidant Response.

REJUV RES.

2017 Aug;20(4):286-297.

(IF 3.811)

1109. Wang Y, Yin X, Zhao L, Li S, Duan J, Kuang R, Duan J.

.

MicroRNA-200b inhibits pituitary tumor cell proliferation and invasion by targeting PKCα.

Exp Ther Med.

2017 Aug;14(2):1706-1714.

(IF 1.785)

1110. Xu D, Liu Z, Wang S, Peng Y, Sun X.

.

Astrocytes regulate the expression of Sp1R3 on oligodendrocyte progenitor cells through Cx47 and promote their proliferation.

BIOCHEM BIOPH RES CO.

2017 Aug 26;490(3):670-675.

(IF 2.985)

1111. Liu C, Wang Y, Li BS, Yang Q, Tang JM, Min J, Hong SS, Guo WJ, Hong L.

.

Role of transforming growth factor β-1 in the pathogenesis of pelvic organ prolapse: A potential therapeutic target.

Int J Mol Med.

2017 Aug;40(2):347-356.

(IF 3.098)

1112. Liu S, Fei W, Shi Q, Li Q, Kuang Y, Wang C, He C, Hu X.

.

CHAC2, downregulated in gastric and colorectal cancers, acted as a tumor suppressor inducing apoptosis and autophagy through unfolded protein response.

Cell Death Dis.

2017 Aug 24;8(8):e3009.

(IF 6.304)

1113. Wang M, Zhang J, Huang Y, Ji S, Shao G, Feng S, Chen D, Zhao K, Wang Z, Wu A.

.

Cancer-Associated Fibroblasts Autophagy Enhances Progression of Triple-Negative Breast Cancer Cells.

MED SCI MONITOR.

2017 Aug 12;23:3904-3912.

(IF 1.918)

1114. Wang H, Jiang Z, Zhang J, Xie Z, Wang Y, Yang G.

.

Enhanced osteogenic differentiation of rat bone marrow mesenchymal stem cells on titanium substrates by inhibiting Notch3.

Arch Oral Biol.

2017 Aug;80:34-40

(IF 1.931)

1115. Hong S, Hong L, Li B, Wu D, Liu C, Min J, Guo W, Hu M, Tang J, Li Y.

.

The role of GPX1 in the pathogenesis of female pelvic organ prolapse.

PLoS One.

2017 Aug 7;12(8):e0181896.

(IF 2.74)

1116. Yicheng Liang, Hetan Wang, Yuanyuan Sun, Sheng Chen, Haoyou Wang, Rong Huang, Xinyi Zhao, Weineng Fu, Chunlu Yang.

.

miR-198-induced upregulation of Livin may be associated with the prognosis and contribute to the oncogenesis of lung adenocarcinoma.

Oncology Reports.

August 1, 2017.

(IF 3.041)

1117. Chi J, Meng L, Pan S, Lin H, Zhai X, Liu L, Zhou C, Jiang C, Guo H.

.

Primary Culture of Rat Aortic Vascular Smooth Muscle Cells: A New Method.

MED SCI MONITOR.

2017 Aug 19;23:4014-4020.

(IF 1.918)

1118. Zhao X, Wang R, Xiong J, Yan D, Li A, Wang S, Xu J, Zhou J.

.

JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2.

Toxicol Lett.

2017 Aug 5;277:32-40.

(IF 3.569)

1119. Wang Q, Jiang Y, Guo R, Lv R, Liu T, Wei H, Ming H, Tian X.

.

Physcion 8-O-β-glucopyranoside suppresses tumor growth of Hepatocellular carcinoma by downregulating PIM1.

Biomed Pharmacother.

2017 Aug;92:451-458.

(IF 4.545)

1120. Luan W, Li R, Liu L, Ni X, Shi Y, Xia Y, Wang J, Lu F, Xu B.

.

Long non-coding RNA HOTAIR acts as a competing endogenous RNA to promote malignant melanoma progression by sponging miR-152-3p.

ONCOTARGET.

2017 Aug 3;8(49):85401-85414.

(IF 5.168)

1121. Zheng SW, Wan WG, Miao HX, Tang R, Wang B, Huang QZ, Liu WL, Zheng JP, Chen CQ, Zhong HB, Li SF, Sun CH.

.

Leptocarpin Suppresses Proliferation, Migration, and Invasion of Human Osteosarcoma by Targeting Type-1 Insulin-Like Growth Factor Receptor (IGF-1R).

MED SCI MONITOR.

2017 Aug 27;23:4132-4140.

(IF 1.918)

1122. Lv H, Liu Q, Wen Z, Feng H, Deng X, Ci X.

.

Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis.

Redox Biol.

2017 Aug;12:311-324.

(IF 9.986)

1123. Zhang D, Li C, Song Y, Zhou J, Li Y, Li J, Bai C.

.

Integrin αvβ5 inhibition protects against ischemia-reperfusion-induced lung injury in an autophagy-dependent manner.

AM J PHYSIOL-LUNG C.

2017 Aug 1;313(2):L384-L394.

(IF 4.406)

1124. Liang Y, Niu H, Ma L, Du D, Wen L, Xia Q, Huang W.

.

Eriodictyol 7‑O‑β‑D glucopyranoside from Coreopsis tinctoria Nutt. ameliorates lipid disorders via protecting mitochondrial function and suppressing lipogenesis.

Mol Med Rep.

2017 Aug;16(2):1298-1306.

(IF 2.1)

1125. Sun HJ, Xu DY, Sun YX, Xue T, Zhang CX, Zhang ZX, Lin W, Li KX.

.

CO-releasing molecules-2 attenuates ox-LDL-induced injury in HUVECs by ameliorating mitochondrial function and inhibiting Wnt/β-catenin pathway.

BIOCHEM BIOPH RES CO.

2017 Aug 26;490(3):629-635.

(IF 2.985)

1126. Yin W, Ouyang S, Luo Z, Zeng Q, Hu B, Xu L, Li Y, Xiao B, Yang H.

.

Immature Exosomes Derived from MicroRNA-146a Overexpressing Dendritic Cells Act as Antigen-Specific Therapy for Myasthenia Gravis.

Inflammation.

2017 Aug;40(4):1460-1473.

(IF 3.212)

1127. Zhenhua Feng, Wenhao Zheng, Qian Tang, Liang Cheng, Hang Li, Wenfei Ni, Xiaoyun Pan.

.

Fludarabine inhibits STAT1-mediated up-regulation of caspase-3 expression in dexamethasone-induced osteoblasts apoptosis and slows the progression of steroid-induced avascular necrosis of the femoral head in rats.

Apoptosis.

August 2017, Volume 22, Issue 8, pp 1001–1012.

(IF 4.543)

1128. Cheng P, Wang T, Li W, Muhammad I, Wang H, Sun X, Yang Y, Li J, Xiao T, Zhang X.

.

Baicalin Alleviates Lipopolysaccharide-Induced Liver Inflammation in Chicken by Suppressing TLR4-Mediated NF-κB Pathway.

Front Pharmacol.

2017 Aug 18;8:547.

(IF 4.225)

1129. Ai-Jun Xu, Li-Na Fu, Hua-Xing Wu, Xiao-Li Yao, Rui Meng.

.

MicroRNA-744 inhibits tumor cell proliferation and invasion of gastric cancer via targeting brain‑derived neurotrophic factor.

Molecular Medicine Reports.

August 4, 2017.

(IF 1.851)

1130. Shenglan Wang, Xuemei Wang, Zhanping Weng, Shuping Zhang, Hui Ning, Baolai Li.

.

Expression and role of microRNA 18b and hypoxia inducible factor-1α in placental tissues of preeclampsia patients.

Experimental and Therapeutic Medicine.

August 30, 2017.

(IF 1.448)

1131. Yan J, Lai CH, Lung SC, Wang WC, Huang CC, Chen GW, Suo G, Choug CT, Lin CH.

.

Carbon black aggregates cause endothelial dysfunction by activating ROCK.

J Hazard Mater.

2017 Sep 15;338:66-75.

(IF 9.038)

1132. Xiaojing Wang, Tianyuan Xu, Fengbin Gao, Hongchao He, Yu Zhu, Zhoujun Shen.

.

Targeting of CCN2 suppresses tumor progression and improves chemo-sensitivity in urothelial bladder cancer.

ONCOTARGET.

2017 Sep 12; 8(39): 66316–66327.

(IF 5.168)

1133. Wenshuai Li, Huilu Zhang, Pei Min, Jie Zhu, Diannan Xu, Weiru Jiang, Yanyun Ma, Jigang Qiu, Weihong Xu, Jian Chen, Mingqing Zhang, Min Li, Dongqin Yang, Jianping Shi, Jun Zhang, Jie Liu.

.

Downregulated miRNA-1269a variant (rs73239138) decreases the susceptibility to gastric cancer via targeting ZNF70.

Oncology Letters.

September 28, 2017.

(IF 1.871)

1134. Li X, Zhou X, Chen Y, Yu S, Chen X, Xia X, Shi X, Zhang Y, Fan D.

.

Surface changes of nanotopography by carbon ion implantation to enhance the biocompatibility of silicone rubber: an in vitro study of the optimum ion fluence and adsorbed protein.

J MATER SCI-MATER M.

2017 Sep 15;28(10):167.

(IF 2.489)

1135. Yin J, Xia W, Li Y, Guo C, Zhang Y, Huang S, Jia Z, Zhang A.

.

COX-2 mediates PM2.5-induced apoptosis and inflammation in vascular endothelial cells.

Am J Transl Res.

2017 Sep 15;9(9):3967-3976. eCollection 2017.

(IF 3.375)

1136. Yilian Pan, Xiaoyi Liu, Yong Huang.

.

Small interfering RNA-mediated knockdown of Twist attenuates the aggressive phenotypes of human endometrial carcinoma Ishikawa cells.

Experimental and Therapeutic Medicine.

September 27, 2017.

(IF 1.448)

1137. Cuiting Qiu, Haijun Zheng, Huiren Tao, Wenjun Yu, Xiaoyu Jiang, Aiqin Li, Hui Jin, Anlin Lv, Huan Li.

.

Vitamin K2 inhibits rat vascular smooth muscle cell calcification by restoring the Gas6/Axl/Akt anti-apoptotic pathway.

Molecular and Cellular Biochemistry.

September 2017, Volume 433, Issue 1–2, pp 149–159.

(IF 2.884)

1138. Lei Zhao, Hui Lin, Songfeng Chen, Sheng Chen, Min Cui, Deyao Shi, Baichuan Wang, Kaige Ma, Zengwu Shao.

.

Hydrogen peroxide induces programmed necrosis in rat nucleus pulposus cells through the RIP1/RIP3-PARP-AIF pathway.

Journal of Orthopaedic Research.

28 September 2017.

(IF 3.043)

1139. Zhang Z, Li S, Jiang H, Liu B, Lv Z, Guo C, Zhang H.

.

Effects of selenium on apoptosis and abnormal amino acid metabolism induced by excess fatty acid in isolated rat hepatocytes.

Mol Nutr Food Res.

2017 Sep;61(9).

(IF 5.309)

1140. Zhou K, Luo X, Wang Y, Cao D, Sun G.

.

MicroRNA-30a suppresses tumor progression by blocking Ras/Raf/MEK/ERK signaling pathway in hepatocellular carcinoma.

Biomed Pharmacother.

2017 Sep;93:1025-1032.

(IF 4.545)

1141. Yuan Liu, Dexiang Liu, Jingjing Xu, Hong Jiang, Fang Pan.

.

Early adolescent stress-induced changes in prefrontal cortex miRNA-135a and hippocampal miRNA-16 in male rats.

Developmental Psychobiology.

25 September 2017.

(IF 1.855)

1142. Guo XQ, Cao YL, Hao F, Yan ZR, Wang ML, Liu XW.

.

Tangeretin alters neuronal apoptosis and ameliorates the severity of seizures in experimental epilepsy-induced rats by modulating apoptotic protein expressions, regulating matrix metalloproteinases, and activating the PI3K/Akt cell survival pathway.

ADV MED SCI-POLAND.

2017 Sep;62(2):246-253.

(IF 2.57)

1143. Biao Ding, Liang-Ze Wan, Yu-Qing Zhang.

.

Biosafety Evaluation of Three Sodium Lauryl N‐Amino Acids Synthesized from Silk Industrial Waste in Mice.

JOURNAL OF SURFACTANTS AND DETERGENTS.

Volume20, Issue5, September 2017, Pages 1173-1187.

(IF 1.672)

1144. Zhao H, Duan Q, Zhang Z, Li H, Wu H, Shen Q, Wang C, Yin T.

.

Up-regulation of glycolysis promotes the stemness and EMT phenotypes in gemcitabine-resistant pancreatic cancer cells.

J Cell Mol Med.

2017 Sep;21(9):2055-2067.

(IF 4.486)

1145. Juan Li, Chun-Xia Zhang, Yi-Mei Liu, Ke-Li Chen, Gang Chen.

.

A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction.

ONCOTARGET.

2017 Sep 12; 8(39): 65717–65729.

(IF 5.168)

1146. Lu-Lu Wang, Lan-Bo Zhou, Jin Shu, Nan-Nan Li, Hui-Wen Zhang, Rui Jin, Li-Li Zhuang, Guo-Ping Zhou.

.

Up-regulation of IRF-3 expression through GATA-1 acetylation by histone deacetylase inhibitor in lung adenocarcinoma A549 cells.

ONCOTARGET.

2017 Sep 29; 8(44): 75943–75951.

(IF 5.168)

1147. Zheng H, Wu J, Shi J, Lu C, Wang Y, Sun Q, Zhang G, Zhao G.

.

miR-125a-5p upregulation suppresses the proliferation and induces the cell apoptosis of lung adenocarcinoma by targeting NEDD9.

Oncol Rep.

2017 Sep;38(3):1790-1796.

(IF 3.417)

1148. Zhang D, Wang F, Pang Y, Ke XX, Zhu S, Zhao E, Zhang K, Chen L, Cui H.

.

Down-regulation of CHERP inhibits neuroblastoma cell proliferation and induces apoptosis through ER stress induction.

ONCOTARGET.

2017 Sep 15;8(46):80956-80970.

(IF 5.168)

1149. Hong Yang, Fei Huang, Yulong Tao, Xinbin Zhao, Lina Liao, Xia Tao.

.

Simvastatin ameliorates ionizing radiation-induced apoptosis in the thymus by activating the AKT/sirtuin 1 pathway in mice.

International Journal of Molecular Medicine.

September 2017, Volume 40 Issue 3.

(IF 2.928)

1150. Yuan Xu, Yi-Fan Han, Shao-Jun Zhu, Jian-Da Dong, Bing Ye.

.

miRNA-148a inhibits cell growth of papillary thyroid cancer through STAT3 and PI3K/AKT signaling pathways.

Oncology Reports.

September 7, 2017.

(IF 3.041)

1151. Yuan Q, Cao G, Li J, Zhang Y, Yang W.

.

MicroRNA-136 inhibits colon cancer cell proliferation and invasion through targeting liver receptor homolog-1/Wnt signaling.

Gene.

2017 Sep 10;628:48-55.

(IF 2.984)

1152. Jiangang Wang, Bing Xiao, Fang Han, Yuxiu Shi.

.

Metformin Alleviated the Neuronal Oxidative Stress in Hippocampus of Rats under Single Prolonged Stress.

Journal of Molecular Neuroscience.

September 2017, Volume 63, Issue 1, pp 28–35.

(IF 2.577)

1153. Gong G, An F, Wang Y, Bian M, Yu LJ, Wei C.

.

miR-15b represses BACE1 expression in sporadic Alzheimer's disease.

ONCOTARGET.

2017 Sep 21;8(53):91551-91557.

(IF 5.168)

1154. Zhu X, Zhou Y, Cai W, Sun H, Qiu L.

.

Salusin-β mediates high glucose-induced endothelial injury via disruption of AMPK signaling pathway.

BIOCHEM BIOPH RES CO.

2017 Sep 16;491(2):515-521.

(IF 2.985)

1155. Juying Liu, Wei Chen, Zhenzhang Chen, Jing Wen, Hongliang Yu, Feijiang Wang, Lirong Wu, Xia He.

.

The effects of microRNA-98 inhibits cell proliferation and invasion by targeting STAT3 in nasopharyngeal carcinoma.

Biomedicine & Pharmacotherapy.

Volume 93, September 2017, Pages 869-878.

(IF 3.743)

1156. Li J, Qian C, Zhou Q, Li J, Li K, Yi P.

.

BEBT-908: A novel potent PI3K/HDAC inhibitor against diffuse large B-cell lymphoma.

BIOCHEM BIOPH RES CO.

2017 Sep 30;491(4):939-945.

(IF 2.985)

1157. Qinjun Chu, Dan Shen, Long He, Hongwei Wang, Chunlan Liu, Wei Zhang.

.

Prognostic significance of SOCS3 and its biological function in colorectal cancer.

Gene.

Volume 627, 5 September 2017, Pages 114-122.

(IF 2.984)

1158. Yawen Ma, Yixue Xue, Xiaobai Liu, Chengbin Qu, Heng Cai, Ping Wang, Zhiqing Li, Zhen Li, Yunhui Liu.

.

SNHG15 affects the growth of glioma microvascular endothelial cells by negatively regulating miR-153.

Oncology Reports.

September 21, 2017.

(IF 3.041)

1159. Nan-Qi Zhang, Cui-Zhu Wang, Zhen-zhou Wang, Zhuo Li, Jing-Ying Sai, Yan Meng, Fang Wang, Ping-Ya Li, Jin-Ping Liu.

.

Anti-myocardial ischaemic effect of pseudoginsenoside F11 by inhibiting expression of beta1-adrenoceptor in rats with coronary artery ligation.

Journal of Functional Foods.

Volume 36, September 2017, Pages 224-232.

(IF 3.197)

1160. Duan WN, Xia ZY, Liu M, Sun Q, Lei SQ, Wu XJ, Meng QT, Leng Y.

.

Protective effects of SOCS3 overexpression in high glucose‑induced lung epithelial cell injury through the JAK2/STAT3 pathway.

Mol Med Rep.

2017 Sep;16(3):2668-2674.

(IF 2.1)

1161. Liu W, Zhang B, Chen G, Wu W, Zhou L, Shi Y, Zeng Q, Li Y, Sun Y, Deng X, Wang F.

.

Targeting miR-21 with Sophocarpine Inhibits Tumor Progression and Reverses Epithelial-Mesenchymal Transition in Head and Neck Cancer.

Mol Ther.

2017 Sep 6;25(9):2129-2139.

(IF 8.986)

1162. Lu C, Cui C, Liu B, Zou S, Song H, Tian H, Zhao J, Li Y.

.

FERMT3 contributes to glioblastoma cell proliferation and chemoresistance to temozolomide through integrin mediated Wnt signaling.

Neurosci Lett.

2017 Sep 14;657:77-83.

(IF 2.274)

1163. Bin Feng, Meng R, Bin Huang, Bi Y, Shen S, Zhu D.

.

Silymarin protects against renal injury through normalization of lipid metabolism and mitochondrial biogenesis in high fat-fed mice.

FREE RADICAL BIO MED.

2017 Sep;110:240-249.

(IF 6.17)

1164. Sun Q, Shen ZY, Duan WN, Meng QT, Xia ZY.

.

Mechanism of myocardial ischemia/reperfusion-induced acute kidney injury through DJ-1/Nrf2 pathway in diabetic rats.

Exp Ther Med.

2017 Nov;14(5):4201-4207. doi: 10.3892/etm.2017.5095. Epub 2017 Sep 1.

(IF 1.785)

1165. Guan H, Piao H, Qian Z, Zhou X, Sun Y, Gao C, Li S, Piao F.

.

2,5-Hexanedione induces autophagic death of VSC4.1 cells via a PI3K/Akt/mTOR pathway.

Mol Biosyst.

2017 Sep 26;13(10):1993-2005.

(IF 3.336)

1166. Zhang L, Zhou L, Song X, Liang G, Xu Z, Wang F, Huang F, Jiang G.

.

Involvement of exogenous 3‑deoxyglucosone in β-cell dysfunction induces impaired glucose regulation.

Mol Med Rep.

2017 Sep;16(3):2976-2984.

(IF 2.1)

1167. Li HH, Sun YL, Cui DM, Wu J, Zeng JW.

.

Effect of dopamine on bone morphogenesis protein-2 expression in human retinal pigment epithelium.

INT J OPHTHALMOL-CH.

2017 Sep 18;10(9):1370-1373.

(IF 1.166)

1168. Gu CJ, Cheng J, Zhang B, Yang SL, Xie F, Sun JS, Huang LQ, Yu JJ, Li MQ.

.

Protopanaxadiol and metformin synergistically inhibit estrogen-mediated proliferation and anti-autophagy effects in endometrial cancer cells.

Am J Transl Res.

2017 Sep 15;9(9):4071-4082. eCollection 2017.

(IF 3.375)

1169. Shao P, Qu WK, Wang CY, Tian Y, Ye ML, Sun DG, Sui JD, Wang LM, Fan R, Gao ZM.

.

MicroRNA-205-5p regulates the chemotherapeutic resistance of hepatocellular carcinoma cells by targeting PTEN/JNK/ANXA3 pathway.

Am J Transl Res.

2017 Sep 15;9(9):4300-4307. eCollection 2017.

(IF 3.375)

1170. Luo K, Chen P, Li S, Li W, He M, Wang T, Chen J.

.

Effect of L-arginine supplementation on the hepatic phosphatidylinositol 3-kinase signaling pathway and gluconeogenic enzymes in early intrauterine growth-restricted rats.

Exp Ther Med.

2017 Sep;14(3):2355-2360.

(IF 1.785)

1171. Yanhui Lou, Huanhuan Jiang, Zhumei Cui, Lingzhi Wang, Xiangyu Wang, Tian Tian.

.

Linc-ROR induces epithelial-to-mesenchymal transition in ovarian cancer by increasing Wnt/β-catenin signaling.

ONCOTARGET.

2017 Sep 19; 8(41): 69983–69994.

(IF 5.168)

1172. Li X, Cheng Q, Li J, He Y, Tian P, Xu C.

.

Significance of hydrogen sulfide in sepsis-induced myocardial injury in rats.

Exp Ther Med.

2017 Sep;14(3):2153-2161.

(IF 1.785)

1173. Feng Z, Zheng W, Li X, Lin J, Xie C, Li H, Cheng L, Wu A, Ni W.

.

Cryptotanshinone protects against IL-1β-induced inflammation in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice.

Int Immunopharmacol.

2017 Sep;50:161-167.

(IF 3.943)

1174. Yang H, Zhao N, Lv L, Yan X, Hu S, Xu T.

.

Functional research and molecular mechanism of Kainic acid-induced denitrosylation of thioredoxin-1 in rat hippocampus.

Neurochem Int.

2017 Sep;108:448-456.

(IF 3.881)

1175. Dang Y, Zhao Q, Luo B, Pan L, Wei Q, Zhang R, Fan Q, Chen J, Chang R, Zhang J, Li Z.

.

Effects of acrylonitrile-induced oxidative stress on testicular apoptosis through activation of NF-κB signaling pathway in male sprague dawley rats.

Am J Transl Res.

2017 Sep 15;9(9):4227-4235. eCollection 2017.

(IF 3.375)

1176. P Gao, X‐H Qiao, L‐M Gou, Y Huang, Q‐H Li, L‐J Li, X‐Y Wang, C‐J Li.

.

TGF‐β1 attenuated branching morphogenesis of embryonic murine submandibular gland through Smad3 activation.

Anatomia Histologia Embryologia.

07 September 2017.

(IF 0.657)

1177. Wu XL, Yang ZW, He L, Dong PD, Hou MX, Meng XK, Zhao HP, Wang ZY, Wang F, Baoluri, Wurenqimuge, Agudamu, Jia YF, Shi L.

.

RRS1 silencing suppresses colorectal cancer cell proliferation and tumorigenesis by inhibiting G2/M progression and angiogenesis.

ONCOTARGET.

2017 Sep 15;8(47):82968-82980.

(IF 5.168)

1178. Ma J, Hu X, Li J, Wu D, Lan Q, Wang Q, Tian S, Dong W.

.

Enhancing conventional chemotherapy drug cisplatin-induced anti-tumor effects on human gastric cancer cells both in vitro and in vivo by Thymoquinone targeting PTEN gene.

ONCOTARGET.

2017 Sep 8;8(49):85926-85939.

(IF 5.168)

1179. Yin M, Zhang P, Yu F, Zhang Z, Cai Q, Lu W, Li B, Qin W, Cheng M, Wang H, Gao H.

.

Grape seed procyanidin B2 ameliorates hepatic lipid metabolism disorders in db/db mice.

Mol Med Rep.

2017 Sep;16(3):2844-2850.

(IF 2.1)

1180. Zhongkun Ren, Rongping Zhang, Yuanyuan Li, Yu Li, Zhiyong Yang, Hui Yang.

.

Ferulic acid exerts neuroprotective effects against cerebral ischemia/reperfusion-induced injury via antioxidant and anti-apoptotic mechanisms in vitro and in vivo.

International Journal of Molecular Medicine.

September 7, 2017.

(IF 2.928)

1181. Gan F, Zhou Y, Hou L, Qian G, Chen X, Huang K.

.

Ochratoxin A induces nephrotoxicity and immunotoxicity through different MAPK signaling pathways in PK15 cells and porcine primary splenocytes.

Chemosphere.

2017 Sep;182:630-637.

(IF 5.778)

1182. Xianli Ma, Shengjin Qi, Zhenying Duan, Hongzhan Liao, Baohua Yang, Wenbo Wang, Jie Tan, Qinghua Li, Xuewei Xia.

.

Long non‐coding RNA LOC554202 modulates chordoma cell proliferation and invasion by recruiting EZH2 and regulating miR‐31 expression.

Cell Proliferation.

30 September 2017.

(IF 5.039)

1183. Wang J, Zhou J, Wang Y, Yang C, Fu M, Zhang J, Han X, Li Z, Hu K, Ge J.

.

Qiliqiangxin protects against anoxic injury in cardiac microvascular endothelial cells via NRG-1/ErbB-PI3K/Akt/mTOR pathway.

J Cell Mol Med.

2017 Sep;21(9):1905-1914.

(IF 4.486)

1184. Yan P, Bai L, Lu W, Gao Y, Bi Y, Lv G.

.

Regulation of autophagy by AMP-activated protein kinase/sirtuin 1 pathway reduces spinal cord neurons damage.

Iran J Basic Med Sci.

2017 Sep;20(9):1029-1036.

(IF 2.146)

1185. Wen X, Xiao L, Zhong Z, Wang L, Li Z, Pan X, Liu Z.

.

Astaxanthin acts via LRP-1 to inhibit inflammation and reverse lipopolysaccharide-induced M1/M2 polarization of microglial cells.

ONCOTARGET.

2017 Sep 3;8(41):69370-69385.

(IF 5.168)

1186. Hou L, Meng M, Chen Y, Wang C.

.

A water-soluble polysaccharide from Grifola frondosa induced macrophages activation via TLR4-MyD88-IKKβ-NF-κB p65 pathways.

ONCOTARGET.

2017 Sep 23;8(49):86604-86614.

(IF 5.168)

1187. Xiaolei Li, Hui Chen, Yu Sun, Jihang Dai, Shuguang Wang, Jingcheng Wang, Lianqi Yan.

.

Hydroxycamptothecin prevents intraarticular scar adhesion by activating the PERK signal pathway.

European Journal of Pharmacology.

5 September 2017, Pages 36-43.

(IF 3.17)

1188. Wang H, Sun R, Chi Z, Li S, Hao L.

.

Silencing of Y-box binding protein-1 by RNA interference inhibits proliferation, invasion, and metastasis, and enhances sensitivity to cisplatin through NF-κB signaling pathway in human neuroblastoma SH-SY5Y cells.

Mol Cell Biochem.

2017 Sep;433(1-2):1-12.

(IF 2.795)

1189. Jiang L, Xu G, Li Z, Zeng X, Li Z, Liu J, Mei L, Li X.

.

RNAi-mediated knockdown of CAIX enhances the radiosensitivity of nasopharyngeal carcinoma cell line, CNE-2.

ONCOTARGETS THER.

2017 Sep 25;10:4701-4709.

(IF 3.337)

1190. Yang C, Zhang JJ, Peng YP, Zhu Y, Yin LD, Wei JS, Gao WT, Jiang KR, Miao Y.

.

A Yin-Yang 1/miR-30a regulatory circuit modulates autophagy in pancreatic cancer cells.

J Transl Med.

2017 Oct 19;15(1):211.

(IF 4.124)

1191. Xu Q, Liu X, Wang X, Hua Y, Wang X, Chen J, Li J, Wang Y, Stoeger T, Chen S, Huang N.

.

Growth arrest-specific protein 7 regulates the murine M1 alveolar macrophage polarization.

Immunol Res.

2017 Oct;65(5):1065-1073.

(IF 2.507)

1192. Zhang CH, Zheng L, Gui L, Lin JY, Zhu YM, Deng WS, Luo M.

.

Soluble epoxide hydrolase inhibition with t-TUCB alleviates liver fibrosis and portal pressure in carbon tetrachloride-induced cirrhosis in rats.

CLIN RES HEPATOL GAS.

2017 Oct 11. pii: S2210-7401(17)30187-0.

(IF 2.718)

1193. Kang H, Yang K, Xiao L, Guo L, Guo C, Yan Y, Qi J, Wang F, Ryffel B, Li C, Deng L.

.

Osteoblast Hypoxia-Inducible Factor-1α Pathway Activation Restrains Osteoclastogenesis via the Interleukin-33-MicroRNA-34a-Notch1 Pathway.

Front Immunol.

2017 Oct 16;8:1312.

(IF 5.085)

1194. Xiaoyan Li, Yuansheng Ding, Naiqing Liu, Qinli Sun, Jie Zhang.

.

MicroRNA-760 inhibits cell proliferation and invasion of colorectal cancer by targeting the SP1-mediated PTEN/AKT signalling pathway.

Molecular Medicine Reports.

October 17, 2017.

(IF 1.851)

1195. Geng YD, Zhang C, Lei JL, Yu P, Xia YZ, Zhang H, Yang L, Kong LY.

.

Walsuronoid B induces mitochondrial and lysosomal dysfunction leading to apoptotic rather than autophagic cell death via ROS/p53 signaling pathways in liver cancer.

Biochem Pharmacol.

2017 Oct 15;142:71-86.

(IF 4.96)

1196. Feng Z, Li X, Lin J, Zheng W, Hu Z, Xuan J, Ni W, Pan X.

.

Oleuropein inhibits the IL-1β-induced expression of inflammatory mediators by suppressing the activation of NF-κB and MAPKs in human osteoarthritis chondrocytes.

Food Funct.

2017 Oct 18;8(10):3737-3744.

(IF 4.171)

1197. Xiancai Ge, Haiyan Cui, Yanbing Zhou, Deying Yin, Yuanyuan Feng, Qun Xin, Xianhui Xu, Weijing Liu, Shanglong Liu, Qin Zhang.

.

miR-320a modulates cell growth and chemosensitivity via regulating ADAM10 in gastric cancer.

Molecular Medicine Reports.

October 19, 2017.

(IF 1.851)

1198. Mingqi Qu, Ju Yu, Hongyuan Liu, Ying Ren, Chunxiao Ma, Xingyao Bu, Qing Lan.

.

The Candidate Tumor Suppressor Gene SLC8A2 Inhibits Invasion, Angiogenesis and Growth of Glioblastoma.

Mol Cells.

2017 Oct 31; 40(10): 761–772.

(IF 4.081)

1199. Qi B, Hu L, Zhu L, Shang L, Wang X, Liu N, Wen N, Hong Y, Fang D.

.

Metformin Attenuates Neurological Deficit after Intracerebral Hemorrhage by Inhibiting Apoptosis, Oxidative Stress and Neuroinflammation in Rats.

Neurochem Res.

2017 Oct;42(10):2912-2920.

(IF 3.038)

1200. Jingjing Shen, Yaoguang Chang, Shujun Dong, Feng Chen.

.

Cloning, expression and characterization of a ι-carrageenase from marine bacterium Wenyingzhuangia fucanilytica: A biocatalyst for producing ι-carrageenan oligosaccharides.

Journal of Biotechnology.

Volume 259, 10 October 2017, Pages 103-109.

(IF 3.163)

1201. Wang XY, Li YL, Wang HY, Zhu M, Guo D, Wang GL, Gao YT, Yang Z, Li T, Yang CY, Chen YM.

.

Propofol inhibits invasion and proliferation of C6 glioma cells by regulating the Ca2+ permeable AMPA receptor-system xc- pathway.

Toxicol In Vitro.

2017 Oct;44:57-65.

(IF 2.959)

1202. Feng Xu, Xiao-Chun Liu, Li Li, Chao-Nan Ma, Ya-Jun Zhang.

.

Effects of TRPC1 on epithelial mesenchymal transition in human airway in chronic obstructive pulmonary disease.

MEDICINE.

2017 Oct; 96(43): e8166.

(IF 1.552)

1203. Zhao Y, Wu X, Qian L, Guo L, Liao J, Wu X.

.

Activating transcription factor 3 protects mice against pseudomonas aeruginosa-induced acute lung injury by interacting with lipopolysaccharide binding protein.

Mol Immunol.

2017 Oct;90:27-32.

(IF 3.641)

1204. Jiang J.

.

Diaphanous-related formin-3 overexpression inhibits the migration and invasion of triple-negative breast cancer by inhibiting RhoA-GTP expression.

Biomed Pharmacother.

2017 Oct;94:439-445.

(IF 4.545)

1205. Liu C, Hu W, Cheng T, Peng Z, Mita K, Xia Q.

.

Osiris9a is a major component of silk fiber in lepidopteran insects.

INSECT BIOCHEM MOLEC.

2017 Oct;89:107-115.

(IF 3.827)

1206. Li CY, Wang YH, Lin ZY, Yang LW, Gao SL, Liu T, Zou BA, Pan ZC, Song ZQ, Liu G.

.

MiR-5100 targets TOB2 to drive epithelial-mesenchymal transition associated with activating smad2/3 in lung epithelial cells.

Am J Transl Res.

2017 Oct 15;9(10):4694-4706. eCollection 2017.

(IF 3.375)

1207. Liu Y, Shi F, Bo L, Zhi W, Weng J, Qu S.

.

A novel alginate-encapsulated system to study biological response to critical-sized wear particles of UHMWPE loaded with alendronate sodium.

MAT SCI ENG C-MATER.

2017 Oct 1;79:679-686.

(IF 5.88)

1208. Xie L, Liu S, Cheng J, Wang L, Liu J, Gong J.

.

Exogenous administration of mitochondrial DNA promotes ischemia reperfusion injury via TLR9-p38 MAPK pathway.

REGUL TOXICOL PHARM.

2017 Oct;89:148-154.

(IF 2.652)

1209. Hao Y, Zheng C, Wang L, Zhang J, Niu X, Song Q, Feng Q, Zhao H, Li L, Zhang H, Zhang Z, Zhang Y.

.

Tumor acidity-activatable manganese phosphate nanoplatform for amplification of photodynamic cancer therapy and magnetic resonance imaging.

Acta Biomater.

2017 Oct 15;62:293-305.

(IF 7.242)

1210. Wang N, Tian X, Chen Y, Tan HQ, Xie PJ, Chen SJ, Fu YC, Chen YX, Xu WC, Wei CJ.

.

Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in db/db mice.

SCI REP-UK.

2017 Oct 31;7(1):14707.

(IF 3.998)

1211. Liu H, Zhai J, Wang B, Fang M.

.

Olig2 Silence Ameliorates Cuprizone-Induced Schizophrenia-Like Symptoms in Mice.

MED SCI MONITOR.

2017 Oct 9;23:4834-4840.

(IF 1.918)

1212. Li-Li Mei, Wen-Jun Wang, Yun-Tan Qiu, Xiu-Feng Xie, Jie Bai, Zhi-Zhou Shi.

.

miR-125b-5p functions as a tumor suppressor gene partially by regulating HMGA2 in esophageal squamous cell carcinoma.

PLOS ONE.

October 2, 2017.

(IF 2.74)

1213. Han Q, Li L, Liang H, Li Y, Xie J, Wang Z.

.

Downregulation of lncRNA X Inactive Specific Transcript (XIST) Suppresses Cell Proliferation and Enhances Radiosensitivity by Upregulating mir-29c in Nasopharyngeal Carcinoma Cells.

MED SCI MONITOR.

2017 Oct 6;23:4798-4807.

(IF 1.918)

1214. Yang Y, Zhao L, Ma J.

.

Penehyclidine hydrochloride preconditioning provides cardiac protection in a rat model of myocardial ischemia/reperfusion injury via the mechanism of mitochondrial dynamics mechanism.

Eur J Pharmacol.

2017 Oct 15;813:130-139.

(IF 3.263)

1215. Jianyou Zhang, Hui Liu, Shitong Li, Jin Wu, Jianhong Sun.

.

SERCA1 attenuates diaphragm relaxation and uptake rate of SERCA in rats with acute sepsis.

Molecular Medicine Reports.

October 2017, Volume 16 Issue 4.

(IF 1.851)

1216. Tuo YL, Ye YF.

.

MGP is downregulated due to promoter methylation in chemoresistant ER+ breast cancer and high MGP expression predicts better survival outcomes.

EUR REV MED PHARMACO.

2017 Oct;21(17):3871-3878.

(IF 3.024)

1217. Lixia Mao, Lunguo Xia, Jiang Chang, Jiaqiang Liu, Lingyong Jiang, Chengtie Wu, Bing Fang.

.

The synergistic effects of Sr and Si bioactive ions on osteogenesis, osteoclastogenesis and angiogenesis for osteoporotic bone regeneration.

Acta Biomaterialia.

Volume 61, 1 October 2017, Pages 217-232.

(IF 6.638)

1218. Zhang TT, Zhang GM, Jin YH, Guo YX, Wang Z, Fan YX, El-Samahy MA, Wang F.

.

Energy restriction affect liver development in Hu sheep ram lambs through Hippo signaling pathway.

Tissue Cell.

2017 Oct;49(5):603-611.

(IF 1.837)

1219. Yang M, Lv Y, Tian X, Lou J, An R, Zhang Q, Li M, Xu L, Dong Z.

.

Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro.

FRONT NEUROSCI-SWITZ.

2017 Oct 26;11:583.

(IF 3.707)

1220. He X, Wu C, Cui Y, Zhu H, Gao Z, Li B, Hua J, Zhao B.

.

The aldehyde group of gossypol induces mitochondrial apoptosis via ROS-SIRT1-p53-PUMA pathway in male germline stem cell.

ONCOTARGET.

2017 Oct 24;8(59):100128-100140.

(IF 5.168)

1221. Guo X, Yan F, Shan X, Li J, Yang Y, Zhang J, Yan X, Bu P.

.

SIRT3 inhibits Ang II-induced transdifferentiation of cardiac fibroblasts through β-catenin/PPAR-γ signaling.

Life Sci.

2017 Oct 1;186:111-117.

(IF 3.647)

1222. Zhang C, Lin J, Ge J, Wang LL, Li N, Sun XT, Cao HB, Li JL.

.

Selenium triggers Nrf2-mediated protection against cadmium-induced chicken hepatocyte autophagy and apoptosis.

Toxicol In Vitro.

2017 Oct;44:349-356.

(IF 2.959)

1223. Zhang M, Ai WW, Mei ZL, Hu YH, Zhang ZL.

.

Delivery of biotinylated IGF-1 with biotinylated self-assembling peptides combined with bone marrow stem cell transplantation promotes cell therapy for myocardial infarction.

Exp Ther Med.

2017 Oct;14(4):3441-3446.

(IF 1.785)

1224. Hu Y, Deng C, Zhang H, Zhang J, Peng B, Hu C.

.

Long non-coding RNA XIST promotes cell growth and metastasis through regulating miR-139-5p mediated Wnt/β-catenin signaling pathway in bladder cancer.

ONCOTARGET.

2017 Oct 10;8(55):94554-94568.

(IF 5.168)

1225. Jian X, Huang W, Wu D, You D, Lin Z, Chen J.

.

Effect of Fibronectin-Coated Micro-Grooved Titanium Surface on Alignment, Adhesion, and Proliferation of Human Gingival Fibroblasts.

MED SCI MONITOR.

2017 Oct 4;23:4749-4759.

(IF 1.918)

1226. Du J, Yang P, Kong F, Liu H.

.

Aberrant expression of translationally controlled tumor protein (TCTP) can lead to radioactive susceptibility and chemosensitivity in lung cancer cells.

ONCOTARGET.

2017 Oct 10;8(60):101922-101935.

(IF 5.168)

1227. Guo R, Lv Y, Ouyang Y, Liu S, Li D.

.

The Role of miR-497/EIF3A Axis in TGFβ1-Induced Epithelial-Mesenchymal Transition and Extracellular Matrix in Rat Alveolar Epithelial Cells and Pulmonary Fibroblasts.

J Cell Biochem.

2017 Oct;118(10):3401-3408.

(IF 4.237)

1228. Zhang CG, Yang SD, Zhu WJ, You BG, Liu Y, Yuan ZQ, Chen WL, Li JZ, Zhou XF, Liu C, Zhang XN.

.

Distinctive polymer micelle designed for siRNA delivery and reversal of MDR1 gene-dependent multidrug resistance.

J BIOMED MATER RES B.

2017 Oct;105(7):2093-2106.

(IF 2.831)

1229. Jiang S, Huang Y, Qi Y, He R, Liu Z, Ma Y, Guo X, Shao Y, Sun Z, Ruan Q.

.

Human cytomegalovirus miR-US5-1 inhibits viral replication by targeting Geminin mRNA.

Virol Sin.

2017 Oct;32(5):431-439.

(IF 3.242)

1230. Wang Z, Bu J, Yao X, Liu C, Shen H, Li X, Li H, Chen G.

.

Phosphorylation at S153 as a Functional Switch of Phosphatidylethanolamine Binding Protein 1 in Cerebral Ischemia-Reperfusion Injury in Rats.

Front Mol Neurosci.

2017 Oct 31;10:358.

(IF 4.057)

1231. Gao F, Liu W, Guo Q, Bai Y, Yang H, Chen H.

.

Physcion blocks cell cycle and induces apoptosis in human B cell precursor acute lymphoblastic leukemia cells by downregulating HOXA5.

Biomed Pharmacother.

2017 Oct;94:850-857.

(IF 4.545)

1232. Lou Y, Wang C, Tang Q, Zheng W, Feng Z, Yu X, Guo X, Wang J.

.

Paeonol Inhibits IL-1β-Induced Inflammation via PI3K/Akt/NF-κB Pathways: In Vivo and Vitro Studies.

Inflammation.

2017 Oct;40(5):1698-1706.

(IF 3.212)

1233. Zhou X, Han TL, Chen H, Baker PN, Qi H, Zhang H.

.

Impaired mitochondrial fusion, autophagy, biogenesis and dysregulated lipid metabolism is associated with preeclampsia.

Exp Cell Res.

2017 Oct 1;359(1):195-204.

(IF 3.383)

1234. Tang M, Jiang L, Lin Y, Wu X, Wang K, He Q, Wang X, Li W.

.

Platelet microparticle-mediated transfer of miR-939 to epithelial ovarian cancer cells promotes epithelial to mesenchymal transition.

ONCOTARGET.

2017 Oct 27;8(57):97464-97475.

(IF 5.168)

1235. Jiang Y, Ren W, Wang W, Xia J, Gou L, Liu M, Wan Q, Zhou L, Weng Y, He T, Zhang Y.

.

Inhibitor of β-catenin and TCF (ICAT) promotes cervical cancer growth and metastasis by disrupting E-cadherin/β-catenin complex.

Oncol Rep.

2017 Nov;38(5):2597-2606.

(IF 3.417)

1236. Lai Q, Luo Z, Wu C, Lai S, Wei H, Li T, Wang Q, Yu Y.

.

Attenuation of cyclosporine A induced nephrotoxicity by schisandrin B through suppression of oxidative stress, apoptosis and autophagy.

Int Immunopharmacol.

2017 Nov;52:15-23.

(IF 3.943)

1237. Hou Z, Hu Y, Yang X, Chen W.

.

Antihypertensive effects of Tartary buckwheat flavonoids by improvement of vascular insulin sensitivity in spontaneously hypertensive rats.

Food Funct.

2017 Nov 15;8(11):4217-4228.

(IF 4.171)

1238. Mingnan Cao, Huixia Wang, Limei Guo, Simin Yang, Chun Liu, Tin Oo Khor, Siwang Yu, Ah-Ng Kong.

.

Dibenzoylmethane Protects Against CCl4-Induced Acute Liver Injury by Activating Nrf2 via JNK, AMPK, and Calcium Signaling.

AAPS J.

November 2017, Volume 19, Issue 6, pp 1703–1714.

(IF 3.737)

1239. Xueyan Liang, Yufang Yang, Zhenguang Huang, Jinling Zhou, Yue’e Li, Xiaobin Zhong.

.

Panax notoginseng saponins mitigate cisplatin induced nephrotoxicity by inducing mitophagy via HIF-1α.

ONCOTARGET.

2017 Nov 28; 8(61): 102989–103003.

(IF 5.168)

1240. Yujie Liu, Jianwei Pan, Lifang Liu, Wei Li, Ran Tao, Yinghu Chen, Huamei Li, Shiqiang Shang.

.

The influence of HCMV infection on autophagy in THP-1 cells.

MEDICINE.

2017 Nov; 96(44): e8298.

(IF 1.552)

1241. Wenyu Xin, Qiaoyun Wang, Dan Zhang, Chaoyun Wang.

.

A new mechanism of inhibition of IL-1β secretion by celastrol through the NLRP3 inflammasome pathway.

European Journal of Pharmacology.

Volume 814, 5 November 2017, Pages 240-247.

(IF 3.17)

1242. Mengchen Shi, Lina Zhou, Lu Zhao, Mei Shang, Tongtong He, Zeli Tang, Hengchang Sun, Pengli Ren, Zhipeng Lin, Tingjin Chen, Jinyun Yu, Jin Xu, Xinbing Yu, Yan Huang.

.

Csseverin inhibits apoptosis through mitochondria-mediated pathways triggered by Ca2 + dyshomeostasis in hepatocarcinoma PLC cells.

PLOS Neglected Tropical Diseases.

November 10, 2017.

(IF 4.487)

1243. Wu N, Hui H, Cui L, Yang F.

.

GRIM-19 represses the proliferation and invasion of cutaneous squamous cell carcinoma cells associated with downregulation of STAT3 signaling.

Biomed Pharmacother.

2017 Nov;95:1169-1176.

(IF 4.545)

1244. Liu H, Yue Q, He S.

.

Amentoflavone suppresses tumor growth in ovarian cancer by modulating Skp2.

Life Sci.

2017 Nov 15;189:96-105.

(IF 3.647)

1245. Han H, Gu S, Chu W, Sun W, Wei W, Dang X, Tian Y, Liu K, Chen J.

.

miR-17-5p Regulates Differential Expression of NCOA3 in Pig Intramuscular and Subcutaneous Adipose Tissue.

Lipids.

2017 Nov;52(11):939-949.

(IF 1.919)

1246. Zhihui Huang, Naidong Zhang, Wenming Ma, Xiaoyu Dai, Jinbo Liu.

.

MiR-337-3p promotes chondrocytes proliferation and inhibits apoptosis by regulating PTEN/AKT axis in osteoarthritis.

Biomedicine & Pharmacotherapy.

Volume 95, November 2017, Pages 1194-1200.

(IF 3.743)

1247. Du WL, Fang Q, Chen Y, Teng JW, Xiao YS, Xie P, Jin B, Wang JQ.

.

Effect of silencing the T‑Box transcription factor TBX2 in prostate cancer PC3 and LNCaP cells.

Mol Med Rep.

2017 Nov;16(5):6050-6058.

(IF 2.1)

1248. Zhao L, Liu S, Xu J, Li W, Duan G, Wang H, Yang H, Yang Z, Zhou R.

.

A new molecular mechanism underlying the EGCG-mediated autophagic modulation of AFP in HepG2 cells.

Cell Death Dis.

2017 Nov 2;8(11):e3160.

(IF 6.304)

1249. Shengwei Liu, Shuang Chen, Weiguang Yuan, Hongyan Wang, Kewang Chen, Dianjun Li, Dalin Li.

.

PD-1/PD-L1 interaction up-regulates MDR1/P-gp expression in breast cancer cells via PI3K/AKT and MAPK/ERK pathways.

ONCOTARGET.

2017 Nov 21; 8(59): 99901–99912.

(IF 5.168)

1250. Shang H, Wang Y, Chao X, Sun G, Bai X, Xu L, Han Y, Li J, Wang H, Fan Z.

.

Artemin transiently increases iNOS expression in primary cultured trigeminal ganglion neurons.

Neurosci Lett.

2017 Nov 1;660:34-38.

(IF 2.274)

1251. Li J, Xu R, Lu X, He J, Jin S.

.

A simple reduction-sensitive micelles co-delivery of paclitaxel and dasatinib to overcome tumor multidrug resistance.

INT J NANOMED.

2017 Nov 1;12:8043-8056.

(IF 5.115)

1252. Xiaoliang Chen, Yanhong Liu, Yanhong Shan, Xingyi Jin, Qingyang Shi, Chunshu Jia.

.

Oxidized low‐density lipoprotein suppresses mouse granulosa cell differentiation through disruption of the hypoxia‐inducible factor 1 pathway.

Early View.

20 November 2017.

1253. Fan H, Ma X, Lin P, Kang Q, Zhao Z, Wang L, Sun D, Cheng J, Li Y.

.

Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats.

MED SCI MONITOR.

2017 Nov 24;23:5599-5612.

(IF 1.918)

1254. Lin H, Ma X, Wang BC, Zhao L, Liu JX, Pu FF, Hu YQ, Hu HZ, Shao ZW.

.

Edaravone ameliorates compression-induced damage in rat nucleus pulposus cells.

Life Sci.

2017 Nov 15;189:76-83.

(IF 3.647)

1255. Liu L, Li N, Zhang Q, Zhou J, Lin L, He X.

.

Inhibition of ERK1/2 Signaling Impairs the Promoting Effects of TGF-β1 on Hepatocellular Carcinoma Cell Invasion and Epithelial-Mesenchymal Transition.

Oncol Res.

2017 Nov 2;25(9):1607-1616.

(IF 4.949)

1256. Liu C, Wu H, Li Y, Shen L, Yu R, Yin H, Sun T, Sun C, Zhou Y, Du Z.

.

SALL4 suppresses PTEN expression to promote glioma cell proliferation via PI3K/AKT signaling pathway.

NEURO-ONCOLOGY.

2017 Nov;135(2):263-272.

(IF 10.247)

1257. Shi J, Zhao W, Ying H, Zhang Y, Du J, Chen S, Li J, Shen B.

.

Estradiol inhibits NLRP3 inflammasome in fibroblast-like synoviocytes activated by lipopolysaccharide and adenosine triphosphate.

Int J Rheum Dis.

2017 Nov 3.

(IF 1.98)

1258. Cui K, Tang Z, Li CC, Wang T, Rao K, Wang SG, Liu JH, Chen Z.

.

Lipoxin A4 improves erectile dysfunction in rats with type I diabetes by inhibiting oxidative stress and corporal fibrosis.

Asian J Androl.

2017 Nov 7.

(IF 2.448)

1259. Pan T, Wu D, Cai N, Chen R, Shi X, Li B, Pan J.

.

Alpha-Mangostin protects rat articular chondrocytes against IL-1β-induced inflammation and slows the progression of osteoarthritis in a rat model.

Int Immunopharmacol.

2017 Nov;52:34-43.

(IF 3.943)

1260. Gong JH, Gong JP, Zheng KW.

.

Checking transfer efficiency and equal loading via qualitative optical way in western blotting.

Electrophoresis.

2017 Nov;38(21):2786-2790.

(IF 3.081)

1261. Zhao H, Tang W, Chen X, Wang S, Wang X, Xu H, Li L.

.

The NAMPT/E2F2/SIRT1 axis promotes proliferation and inhibits p53-dependent apoptosis in human melanoma cells.

BIOCHEM BIOPH RES CO.

2017 Nov 4;493(1):77-84.

(IF 2.985)

1262. Li X, Wang S, Dai J, Yan L, Zhao S, Wang J, Sun Y.

.

Homoharringtonine prevents surgery-induced epidural fibrosis through endoplasmic reticulum stress signaling pathway.

Eur J Pharmacol.

2017 Nov 15;815:437-445.

(IF 3.263)

1263. Liang P, Zhong L, Gong L, Wang J, Zhu Y, Liu W, Yang J.

.

Fibroblast growth factor 21 protects rat cardiomyocytes from endoplasmic reticulum stress by promoting the fibroblast growth factor receptor 1-extracellular signal‑regulated kinase 1/2 signaling pathway.

Int J Mol Med.

2017 Nov;40(5):1477-1485.

(IF 3.098)

1264. Fan S, Yang Z, Ke Z, Huang K, Liu N, Fang X, Wang K.

.

Downregulation of the long non-coding RNA TUG1 is associated with cell proliferation, migration, and invasion in breast cancer.

Biomed Pharmacother.

2017 Nov;95:1636-1643.

(IF 4.545)

1265. Tao S, Ren Y, Zheng H, Zhao M, Zhang X, Zhu Y, Yang J, Zheng S.

.

Salvianolic acid B inhibits intermittent high glucose-induced INS-1 cell apoptosis through regulation of Bcl-2 proteins and mitochondrial membrane potential.

Eur J Pharmacol.

2017 Nov 5;814:56-62.

(IF 3.263)

1266. Fan C, Qiao Y, Tang M.

.

Notoginsenoside R1 attenuates high glucose-induced endothelial damage in rat retinal capillary endothelial cells by modulating the intracellular redox state.

DRUG DES DEV THER.

2017 Nov 23;11:3343-3354.

(IF 3.216)

1267. Wang SQ, Wang X, Zheng K, Liu KS, Wang SX, Xie CH.

.

Simultaneous targeting PI3K and PERK pathways promotes cell death and improves the clinical prognosis in esophageal squamous carcinoma.

BIOCHEM BIOPH RES CO.

2017 Nov 4;493(1):534-541.

(IF 2.985)

1268. Xu C, He T, Li Z, Liu H, Ding B.

.

Regulation of HOXA11-AS/miR-214-3p/EZH2 axis on the growth, migration and invasion of glioma cells.

Biomed Pharmacother.

2017 Nov;95:1504-1513.

(IF 4.545)

1269. Haifeng Zhang, Baoli Hu, Zuopei Wang, Feng Zhang, Haitao Wei, Li Li.

.

miR-181c contributes to cisplatin resistance in non-small cell lung cancer cells by targeting Wnt inhibition factor 1.

Cancer Chemotherapy and Pharmacology.

November 2017, Volume 80, Issue 5, pp 973–984.

(IF 3.008)

1270. Yu L, Wang X, Chen H, Yan Z, Wang M, Li Y.

.

Neurochemical and Behavior Deficits in Rats with Iron and Rotenone Co-treatment: Role of Redox Imbalance and Neuroprotection by Biochanin A.

FRONT NEUROSCI-SWITZ.

2017 Nov 23;11:657.

(IF 3.707)

1271. Mingxia Jiang, Haifen Zhang, Lijie Zhai, Bianliang Ye, Yin Cheng, Chengkai Zhai.

.

ALA/LA ameliorates glucose toxicity on HK-2 cells by attenuating oxidative stress and apoptosis through the ROS/p38/TGF-β1 pathway.

Lipids in Health and Disease.

16 November 2017.

(IF 2.651)

1272. Cao H, Xu H, Zhu G, Liu S.

.

Isoquercetin ameliorated hypoxia/reoxygenation-induced H9C2 cardiomyocyte apoptosis via a mitochondrial-dependent pathway.

Biomed Pharmacother.

2017 Nov;95:938-943.

(IF 4.545)

1273. Lv C, Yuan X, Zeng HW, Liu RH, Zhang WD.

.

Protective effect of cinnamaldehyde against glutamate-induced oxidative stress and apoptosis in PC12 cells.

Eur J Pharmacol.

2017 Nov 15;815:487-494.

(IF 3.263)

1274. Minlan Yang, Yanru Li, Xiangfeng Shen, Yang Ruan, Yan Lu, Xiangshu Jin, Peiye Song, Yantong Guo, Xiaoli Zhang, Huinan Qu, Yijia Shao, Chengshi Quan.

.

CLDN6 promotes chemoresistance through GSTP1 in human breast cancer.

Journal of Experimental & Clinical Cancer Research.

7 November 2017.

(IF 5.646)

1275. Pan S, An L, Meng X, Li L, Ren F, Guan Y.

.

MgCl2 and ZnCl2 promote human umbilical vein endothelial cell migration and invasion and stimulate epithelial-mesenchymal transition via the Wnt/β-catenin pathway.

Exp Ther Med.

2017 Nov;14(5):4663-4670.

(IF 1.785)

1276. Wang J, Huang J, Wang L, Chen C, Yang D, Jin M, Bai C, Song Y.

.

Urban particulate matter triggers lung inflammation via the ROS-MAPK-NF-κB signaling pathway.

J Thorac Dis.

2017 Nov;9(11):4398-4412.

(IF 2.046)

1277. Qiao X, Wang L, Wang Y, Su X, Qi Y, Fan Y, Peng Z.

.

Intermedin inhibits unilateral ureteral obstruction-induced oxidative stress via NADPH oxidase Nox4 and cAMP-dependent mechanisms.

RENAL FAILURE.

2017 Nov;39(1):652-659.

(IF 1.985)

1278. Tang W, Shen M, Xie J, Liu D, Du M, Lin L, Gao H, Hamaker BR, Xie M.

.

Physicochemical characterization, antioxidant activity of polysaccharides from Mesona chinensis Benth and their protective effect on injured NCTC-1469 cells induced by H2O2.

CARBOHYD POLYM.

2017 Nov 1;175:538-546.

(IF 7.182)

1279. Zhou J, Xu R, Du XZ, Zhou XD, Li Q.

.

Saxifragifolin D attenuates phagosome maturation arrest in Mycobacterium tuberculosis-infected macrophages via an AMPK and VPS34-dependent pathway.

AMB Express.

2017 Dec;7(1):11.

(IF 2.499)

1280. Shuixian Li, Qianyun Zhang, Lichun Zhou, Yanhui Guan, Shang Chen, Yu Zhang, Xiuzhen Han.

.

Inhibitory effects of compound DMBT on hypoxia-induced vasculogenic mimicry in human breast cancer.

Biomedicine & Pharmacotherapy.

December 2017, Pages 982-992.

(IF 3.743)

1281. Ni Z, Yi J.

.

Oxymatrine induces nasopharyngeal cancer cell death through inhibition of PI3K/AKT and NF‑κB pathways.

Mol Med Rep.

2017 Dec;16(6):9701-9706.

(IF 2.1)

1282. Zhou L, Chen X, Yan J, Li M, Liu T, Zhu C, Pan G, Guo Q, Yang H, Pei M, He F.

.

Melatonin at pharmacological concentrations suppresses osteoclastogenesis via the attenuation of intracellular ROS.

OSTEOPOROSIS INT.

2017 Dec;28(12):3325-3337.

(IF 3.864)

1283. Feng Y, Wang N, Xu J, Zou J, Liang X, Liu H, Chen Y.

.

Alpha-1-antitrypsin functions as a protective factor in preeclampsia through activating Smad2 and inhibitor of DNA binding 4.

ONCOTARGET.

2017 Dec 5;8(68):113002-113012.

(IF 5.168)

1284. Zhang Y, Su Y, Zhao Y, Lv G, Luo Y.

.

MicroRNA‑720 inhibits pancreatic cancer cell proliferation and invasion by directly targeting cyclin D1.

Mol Med Rep.

2017 Dec;16(6):9256-9262.

(IF 2.1)

1285. Kankan Wang, Xiaochun Tang, Zicong Xie, Xiaodong Zou, Mengjing Li, Hongming Yuan, Nannan Guo, Hongsheng Ouyang, Huping Jiao, Daxin Pang.

.

CRISPR/Cas9-mediated knockout of myostatin in Chinese indigenous Erhualian pigs.

Transgenic Research.

December 2017, Volume 26, Issue 6, pp 799–805.

(IF 1.817)

1286. Jiang H, Bian F, Zhou H, Wang X, Wang K, Mai K, He G.

.

Nutrient sensing and metabolic changes after methionine deprivation in primary muscle cells of turbot (Scophthalmus maximus L.).

J Nutr Biochem.

2017 Dec;50:74-82.

(IF 4.873)

1287. Qing-chun Lu, Zhuang-hua Rui, Zhong-liang Guo, Wang Xie, Shan Shan, Tao Ren.

.

LncRNA-DANCR contributes to lung adenocarcinoma progression by sponging miR‐496 to modulate mTOR expression.

Journal of Cellular and Molecular Medicine.

20 December 2017;

(IF 4.658)

1288. Shuo Zhang, Jiali Chang, Chao Lin, Yiran Pan, Kangping Cui, Xiaoyuan Zhang, Peng Liang, Xia Huang.

.

Enhancement of methanogenesis via direct interspecies electron transfer between Geobacteraceae and Methanosaetaceae conducted by granular activated carbon.

Bioresource Technology.

Volume 245, Part A, December 2017, Pages 132-137.

(IF 6.669)

1289. Li H, Liu D, Li C, Zhou S, Tian D, Xiao D, Zhang H, Gao F, Huang J.

.

Exosomes secreted from mutant-HIF-1α-modified bone-marrow-derived mesenchymal stem cells attenuate early steroid-induced avascular necrosis of femoral head in rabbit.

Cell Biol Int.

2017 Dec;41(12):1379-1390.

(IF 2.571)

1290. Hongyu Han, Yan Yan, Hui Dong, Shunhai Zhu, Qiping Zhao, Qi Zhai, Bing Huang.

.

Characterization and expression analysis of a new small heat shock protein Hsp20.4 from Eimeria tenella.

Experimental Parasitology.

Volume 183, December 2017, Pages 13-22.

(IF 1.719)

1291. Zhen Yang, Mei-lin Zhu, De-hai Li, Rong Zeng, Bing-nan Han.

.

N-Me-trichodermamide B isolated from Penicillium janthinellum, with antioxidant properties through Nrf2-mediated signaling pathway.

Bioorganic & Medicinal Chemistry.

Volume 25, Issue 24, 15 December 2017, Pages 6614-6622.

(IF 2.802)

1292. Zhi-Zhen Pan, Lian Xu, Bo Liu, Jing Zhang, Zheng Chen, Qing-Xi Chen, Yu-Jing Zhu.

.

PxAPN5 serves as a functional receptor of Cry2Ab in Plutella xylostella (L.) and its binding domain analysis.

International Journal of Biological Macromolecules.

Volume 105, Part 1, December 2017, Pages 516-521.

(IF 4.784)

1293. Tingting Meng, Binbin Lu, Shihong Shao, Ming Yuan, Xuan Liu, Hong Yuan, Xuan Huang, Fuqiang Hu.

.

Sequential therapy with redox-responsive glucolipid nanocarrier separately delivering siRNA and doxorubicin to overcome multidrug resistance.

International Journal of Pharmaceutics.

Volume 534, Issues 1–2, 20 December 2017, Pages 368-377.

(IF 4.213)

1294. Xu X, Lv H, Li X, Su H, Zhang X, Yang J.

.

Danshen attenuates osteoarthritis-related cartilage degeneration through inhibition of NF-κB signaling pathway in vivo and in vitro.

Biochem Cell Biol.

2017 Dec;95(6):644-651.

(IF 2.46)

1295. Yunmei Huang, Yu Lin, Yinsheng Wu, Jianwei Zeng, Meiya Huang, Shiming Guo, Wenjuan Luo, Haiming Lin, Yanping Lin.

.

Molecular mechanisms of the inhibitory effects of jiangu granule-containing serum on RANKL-induced osteoclastogenesis.

Molecular Medicine Reports.

December 2017, Volume 16 Issue 6.

(IF 1.851)

1296. Nan Wang, Wei Liu, Tao Tan, Chao-Qun Dong, Duan-Yang Lin, Jun Zhao, Chang Yu, Xiao-Ji Luo.

.

Notch signaling negatively regulates BMP9-induced osteogenic differentiation of mesenchymal progenitor cells by inhibiting JunB expression.

ONCOTARGET.

2017 Dec 12; 8(65): 109661–109674.

(IF 5.168)

1297. Chang Zhang, Pan Gong, Yan Ye, Lulu Zhang, Minjian Chen, Yanhui Hu, Aihua Gu, Shanshan Chen, Yubang Wang.

.

NF-κB-vimentin is involved in steroidogenesis stimulated by mono-butyl phthalate in primary cultured ovarian granulosa cells.

Toxicology in Vitro.

Volume 45, Part 1, December 2017, Pages 25-30.

(IF 3.067)

1298. Shi X, Jiao B, Chen Y, Li S, Chen L.

.

MxA is a positive regulator of type I IFN signaling in HCV infection.

J Med Virol.

2017 Dec;89(12):2173-2180.

(IF 2.021)

1299. Cui S, Li W, Wang P, Lv X, Gao Y, Huang G.

.

Folic acid inhibits homocysteine-induced cell apoptosis in human umbilical vein endothelial cells.

Mol Cell Biochem.

2017 Dec 18.

(IF 2.795)

1300. Wang G, He F, Xu Y, Zhang Y, Wang X, Zhou C, Huang Y, Zou J.

.

Immunopotentiator Thymosin Alpha-1 Promotes Neurogenesis and Cognition in the Developing Mouse via a Systemic Th1 Bias.

Neurosci Bull.

2017 Dec;33(6):675-684.

(IF 4.326)

1301. Zhi-qiang Yuan, Wei-liang Chen, Ben-gang You, Yang Liu, Shu-di Yang, Ji-zhao Li, Wen-jing Zhu, Xiao-feng Zhou, Chun Liu, Xue-nong Zhang.

.

Multifunctional nanoparticles co-delivering EZH2 siRNA and etoposide for synergistic therapy of orthotopic non-small-cell lung tumor.

Journal of Controlled Release.

Volume 268, 28 December 2017, Pages 198-211.

(IF 7.901)

1302. Qiu H, Wu Y, Wang Q, Liu C, Xue L, Wang H, Wu Q, Jiang Q .

.

Effect of berberine on PPARα-NO signalling pathway in vascular smooth muscle cell proliferation inducedby angiotensin IV.

Pharm Biol.

2017 Dec;55(1):227-232.

(IF 2.971)

1303. Cao F, Liu T, Sun S, Feng S.

.

The role of the miR-99b-5p/mTOR signaling pathway in neuroregeneration in mice following spinal cord injury.

Mol Med Rep.

2017 Dec;16(6):9355-9360.

(IF 2.1)

1304. Bi D, Zhou R, Cai N, Lai Q, Han Q, Peng Y, Jiang Z, Tang Z, Lu J, Bao W, Xu H, Xu X.

.

Alginate enhances Toll-like receptor 4-mediated phagocytosis by murine RAW264.7 macrophages.

Int J Biol Macromol.

2017 Dec;105(Pt 2):1446-1454.

(IF 5.162)

1305. Yao X, Ei-Samahy MA, Feng X, Zhang T, Li F, Zhang G, Pang J, Nie H, Wang F.

.

Expression and localization of polypeptide N-acetylgalactosaminyltransferase-like protein 5 in the reproductive organs and sperm of Hu sheep.

Anim Reprod Sci.

2017 Dec;187:159-166.

(IF 1.66)

1306. Han D, Li X, Li S, Su T, Fan L, Fan WS, Qiao HY, Chen JW, Fan MM, Li XJ, Wang YB, Ma S, Qiu Y, Tian ZH, Cao F.

.

Reduced silent information regulator 1 signaling exacerbates sepsis-induced myocardial injury and mitigates the protective effect of a liver X receptor agonist.

FREE RADICAL BIO MED.

2017 Dec;113:291-303.

(IF 6.17)

1307. Wei S, Luo C, Yu S, Gao J, Liu C, Wei Z, Zhang Z, Wei L, Yi B.

.

Erythropoietin ameliorates early brain injury after subarachnoid haemorrhage by modulating microglia polarization via the EPOR/JAK2-STAT3 pathway.

Exp Cell Res.

2017 Dec 15;361(2):342-352.

(IF 3.383)

1308. Jia H, Cui J, Jia X, Zhao J, Feng Y, Zhao P, Zang D, Yu J, Zhao T, Wang H, Xu K.

.

Therapeutic effects of STAT3 inhibition by nifuroxazide on murine acute graft graft-vs.-host disease: Old drug, new use.

Mol Med Rep.

2017 Dec;16(6):9480-9486.

(IF 2.1)

1309. Zhou J, Xu R, Du XZ, Zhou XD, Li Q .

.

Saxifragifolin D attenuates phagosome maturation arrest in Mycobacterium tuberculosis-infectedmacrophages via an AMPK and VPS34-dependent pathway.

AMB Express.

2017 Dec;7(1):11.

(IF 2.499)

1310. Mao M, Zheng X, Jin B, Zhang F, Zhu L, Cui L.

.

Effects of CD44 and E-cadherin overexpression on the proliferation, adhesion and invasion of ovarian cancer cells.

Exp Ther Med.

2017 Dec;14(6):5557-5563.

(IF 1.785)

1311. Yan J, Lai CH, Lung SC, Chen C, Wang WC, Huang PI, Lin CH.

.

Industrial PM2.5 cause pulmonary adverse effect through RhoA/ROCK pathway.

Sci Total Environ.

2017 Dec 1;599-600:1658-1666.

(IF 6.551)

1312. Deng A, Zhang H, Hu M, Liu S, Gao Q, Wang Y, Guo C.

.

Knockdown of Indian hedgehog protein induces an inhibition of cell growth and differentiation in osteoblast MC3T3‑E1 cells.

Mol Med Rep.

2017 Dec;16(6):7987-7992.

(IF 2.1)

1313. Sun Z, Li A, Yu Z, Li X, Guo X, Chen R.

.

MicroRNA-497-5p Suppresses Tumor Cell Growth of Osteosarcoma by Targeting ADP Ribosylation Factor-Like Protein 2.

CANCER BIOTHER RADIO.

2017 Dec;32(10):371-378.

(IF 2.314)

1314. Tang Z, Zhang Z, Tang Y, Qi L, Yang F, Wang Z.

.

Effects of dimethyl carbonate-induced autophagic activation on follicular development in the mouse ovary.

Exp Ther Med.

2017 Dec;14(6):5981-5989.

(IF 1.785)

1315. Zeng X, Chen S, Gao Q, Zong W, Jiang D, Zeng G, Zhou L, Chen L, Luo W, Xiao J, Xiao B, Ouyang D, Hu K.

.

The expression of G protein-coupled receptor kinase 5 and its interaction with dendritic marker microtubule-associated protein-2 after status epilepticus.

Epilepsy Res.

2017 Dec;138:62-70.

(IF 2.208)

1316. Zhang P, Wu C, Huang XH, Shen CL, Li L, Zhang W, Yao CZ.

.

Aspirin suppresses TNF-α-induced MMP-9 expression via NF-κB and MAPK signaling pathways in RAW264.7 cells.

Exp Ther Med.

2017 Dec;14(6):5597-5604.

(IF 1.785)

1317. Lin Y, Wang X, Yu Y, Liu W, Xie F, Ouyang X, Huang Q.

.

Expression and prognostic significance of cyclin-dependent kinase inhibitor 1A in patients with resected gastric adenocarcinoma.

Oncol Lett.

2017 Dec;14(6):7473-7482.

(IF 2.311)

1318. Ma L, Zhang Z, Xue X, Wan Y, Ye B, Lin K.

.

A potent peptide as adiponectin receptor 1 agonist to against fibrosis.

J ENZYM INHIB MED CH.

2017 Dec;32(1):624-631.

(IF 4.673)

1319. Wei Y, Cao XN, Tang XL, Shen LJ, Lin T, He DW, Wu SD, Wei GH.

.

Urban fine particulate matter (PM2.5) exposure destroys blood-testis barrier (BTB) integrity through excessive ROS-mediated autophagy.

TOXICOL MECH METHOD.

2017 Dec 27:1-18.

(IF 2.295)

1320. Gao ZQ, Wang JF, Chen DH, Ma XS, Wu Y, Tang Z, Dang XW.

.

Long non-coding RNA GAS5 suppresses pancreatic cancer metastasis through modulating miR-32-5p/PTEN axis.

Cell Biosci.

2017 Dec 4;7:66.

(IF 5.026)

1321. Li H, Li M, Pang Y, Liu F, Sheng D, Cheng X.

.

Fructose‑1,6‑bisphosphatase‑1 decrease may promote carcinogenesis and chemoresistance in cervical cancer.

Mol Med Rep.

2017 Dec;16(6):8563-8571.

(IF 2.1)

1322. Wang T, Yang B, Ji R, Xu W, Mai K, Ai Q.

.

Omega-3 polyunsaturated fatty acids alleviate hepatic steatosis-induced inflammation through Sirt1-mediated nuclear translocation of NF-κB p65 subunit in hepatocytes of large yellow croaker (Larmichthys crocea).

FISH SHELLFISH IMMUN.

2017 Dec;71:76-82.

(IF 3.298)

1323. Peng L, Shu X, Lang C, Yu X.

.

Cardiotrophin-1 stimulates the neural differentiation of human umbilical cord blood-derived mesenchymal stem cells and survival of differentiated cells through PI3K/Akt-dependent signaling pathways.

Cytotechnology.

2017 Dec;69(6):933-941.

(IF 1.777)

1324. Huang WQ, Wen JL, Lin RQ, Wei P, Huang F.

.

Effects of mTOR/NF-κB signaling pathway and high thoracic epidural anesthesia on myocardial ischemia-reperfusion injury via autophagy in rats.

J Cell Physiol.

2017 Dec 5.

(IF 5.546)

1325. Liang S, Ju X, Zhou Y, Chen Y, Ke G, Wen H, Wu X.

.

Downregulation of eukaryotic initiation factor 4A1 improves radiosensitivity by delaying DNA double strand break repair in cervical cancer.

Oncol Lett.

2017 Dec;14(6):6976-6982.

(IF 2.311)

1326. Qian C, Jin J, Chen J, Li J, Yu X, Mo H, Chen G.

.

SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model.

Mol Med Rep.

2017 Dec;16(6):9627-9635.

(IF 2.1)

1327. Deng H, Kuang P, Cui H, Luo Q, Liu H, Lu Y, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L.

.

Sodium fluoride induces apoptosis in mouse splenocytes by activating ROS-dependent NF-κB signaling.

ONCOTARGET.

2017 Dec 1;8(70):114428-114441.

(IF 5.168)

1328. Wu X, Zhang P, Zhu H, Li S, Chen X, Shi L.

.

Long noncoding RNA FEZF1-AS1 indicates a poor prognosis of gastric cancer and promotes tumorigenesis via activation of Wnt signaling pathway.

Biomed Pharmacother.

2017 Dec;96:1103-1108.

(IF 4.545)

1329. Yu Zhang, Kaiqiang Li, Youmin Ying, Bingyu Chen, Ke Hao, Boxu Chen, Yu Zheng, Jianxin Lyu, Xiangming Tong, Xiaopan Chen, Ying Wang, Zhajun Zhan, Wei Zhang, Zhen Wang.

.

C21 steroid-enriched fraction refined from Marsdenia tenacissima inhibits hepatocellular carcinoma through the coordination of Hippo-Yap and PTEN-PI3K/AKT signaling pathways.

ONCOTARGET.

2017 Dec 15; 8(66): 110576–110591.

(IF 5.168)

1330. Liang B, Xiao T, Long J, Liu M, Li Z, Liu S, Yang J.

.

Hydrogen sulfide alleviates myocardial fibrosis in mice with alcoholic cardiomyopathy by downregulating autophagy.

Int J Mol Med.

2017 Dec;40(6):1781-1791.

(IF 3.098)

1331. Wei Wei, Wenxing Sun, Haiyin Han, Weiwei Chu, Lifan Zhang, Jie Chen.

.

miR-130a regulates differential lipid accumulation between intramuscular and subcutaneous adipose tissues of pigs via suppressing PPARG expression.

Gene.

15 December 2017, Pages 23-29.

(IF 2.984)

1332. Qian L, Zhao Y, Guo L, Li S, Wu X.

.

Activating transcription factor 3 (ATF3) protects against lipopolysaccharide-induced acute lung injury via inhibiting the expression of TL1A.

J Cell Physiol.

2017 Dec;232(12):3727-3734.

(IF 5.546)

1333. Zhibo Li, Zhongyu Jiang, Lei Zhao, Xianrui Yang, Jin Zhang, Xianjing Song, Bin Liu, Jianxun Ding.

.

PEGylated stereocomplex polylactide coating of stent for upregulated biocompatibility and drug storage.

MAT SCI ENG C-MATER.

1 December 2017, Pages 443-451.

(IF 5.88)

1334. Qiu H, Wu Y, Wang Q, Liu C, Xue L, Wang H, Wu Q, Jiang Q.

.

Effect of berberine on PPARα-NO signalling pathway in vascular smooth muscle cell proliferation induced by angiotensin IV.

Pharm Biol.

2017 Dec;55(1):227-232.

(IF 2.971)

1335. Zhu W, Liang Q, Yang X, Yu Y, Shen X, Sun G.

.

Combination of sorafenib and Valproic acid synergistically induces cell apoptosis and inhibits hepatocellular carcinoma growth via down-regulating Notch3 and pAkt.

Am J Cancer Res.

2017 Dec 1;7(12):2503-2514. eCollection 2017.

(IF 5.177)

1336. Guan YD, Jiang SL, Yu P, Wen M, Zhang Y, Xiao SS, Xu XJ, Cheng Y.

.

Suppression of eEF-2K-mediated autophagy enhances the cytotoxicity of raddeanin A against human breast cancer cells in vitro.

Acta Pharmacol Sin.

2017 Dec 14.

(IF 5.064)

1337. Wang G, Pan J, Zhang L, Wei Y, Wang C.

.

Long non-coding RNA CRNDE sponges miR-384 to promote proliferation and metastasis of pancreatic cancer cells through upregulating IRS1.

CELL PROLIFERAT.

2017 Dec;50(6).

(IF 5.753)

1338. Zhou H, Wang L, Xu Q, Liu Q, Liu H, Qiu W, Hu T, Lv Y, Zhang Q.

.

ID3 may protect mice from anti‑GBM glomerulonephritis by regulating the differentiation of Th17 and Treg cells.

Mol Med Rep.

2017 Dec;16(6):9086-9094.

(IF 2.1)

1339. Yanliang Li, Xiaowen Wen, Longgang Wang, Xianjun Sun, Heng Ma, Zheng Fu, Leping Li.

.

LncRNA ZEB1-AS1 predicts unfavorable prognosis in gastric cancer.

SURG ONCOL.

Volume 26, Issue 4, December 2017, Pages 527-534.

(IF 2.521)

1340. Jiao C, Gao F, Ou L, Yu J, Li M, Wei P, Miao F.

.

Tetrahydroxy stilbene glycoside (TSG) antagonizes Aβ-induced hippocampal neuron injury by suppressing mitochondrial dysfunction via Nrf2-dependent HO-1 pathway.

Biomed Pharmacother.

2017 Dec;96:222-228.

(IF 4.545)

1341. An F, Gong G, Wang Y, Bian M, Yu L, Wei C.

.

MiR-124 acts as a target for Alzheimer's disease by regulating BACE1.

ONCOTARGET.

2017 Dec 9;8(69):114065-114071.

(IF 5.168)

1342. Weiming Sun, Jinxia Yang, Yuanzhou Zhang, Yuxin Xi, Xin Wen, Di Yuan, Yuehong Wang, Can Wei, Rui Wang, Lingyun Wu, Hongzhu Li, Changqing Xu.

.

Exogenous H2S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes.

CELL BIOSCI.

11 December 2017.

(IF 5.026)

1343. Chen L, Hu N, Wang C, Zhao H, Gu Y

.

Long non-coding RNA CCAT1 promotes multiple myeloma progression by acting as a molecular sponge of miR-181a-5p to modulate HOXA1 expression.

Cell Cycle.

2018;17(3):319-329.

(IF 3.699)

1344. Lixin Xu, Lijun Yan, Weiwei Tao.

.

Pilose antler peptide attenuates high-fat-diet-induced liver injury.

Toxicology Mechanisms and Methods.

Volume 28, 2018 - Issue 4.

(IF 2.276)

1345. Xilin XU, Hang LV, Xiaodong LI, Hui SU, Xiaofeng ZHANG, Jun YANG.

.

Danshen attenuates cartilage injuries in osteoarthritis in vivo and in vitro by activating JAK2/STAT3 and AKT pathways.

Experimental Animals.

Vol. 67 (2018), No. 2 pp. 127-137.

(IF 1.208)

1346. Fan Y, Luo R, Su LY, Xiang Q, Yu D, Xu L, Chen JQ, Bi R, Wu DD, Zheng P, Yao YG.

.

Does the Genetic Feature of the Chinese Tree Shrew (Tupaia belangeri chinensis) Support Its Potential as a Viable Model for Alzheimer's Disease Research?

J Alzheimers Dis.

2018;61(3):1015-1028.

(IF 3.909)

1347. Dai C, Ciccotosto GD, Cappai R, Tang S, Li D, Xie S, Xiao X, Velkov T

.

Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis.

Mol Neurobiol.

2018 Jan;55(1):421-434.

(IF 4.5)

1348. Chen L, Yan KP, Liu XC, Wang W, Li C, Li M, Qiu CG

.

Valsartan regulates TGF-β/Smads and TGF-β/p38 pathways through lncRNA CHRF to improve doxorubicin-induced heart failure.

Arch Pharm Res.

2018 Jan;41(1):101-109.

(IF 2.934)

1349. Gao X, Zhang X, Hu J, Xu X, Zuo Y, Wang Y, Ding J, Xu H, Zhu S

.

Aconitine induces apoptosis in H9c2 cardiac cells via mitochondria‑mediated pathway.

Mol Med Rep.

2018 Jan;17(1):284-292.

(IF 2.1)

1350. Yuan C, Pu L, He Z, Wang J

.

BNIP3/Bcl-2-mediated apoptosis induced by cyclic tensile stretch in human cartilage endplate-derived stem cells.

Exp Ther Med.

2018 Jan;15(1):235-241.

(IF 1.785)

1351. Wang W, Yao GD, Shang XY, Gao JC, Zhang Y, Song SJ

.

Eclalbasaponin I from Aralia elata (Miq.) Seem. reduces oxidative stress-induced neural cell death by autophagy activation.

Biomed Pharmacother.

2018 Jan;97:152-161.

(IF 4.545)

1352. Chen L, Lu FB, Chen DZ, Wu JL, Hu ED, Xu LM, Zheng MH, Li H, Huang Y, Jin XY, Gong YW, Lin Z, Wang XD, Chen YP

.

BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis.

Mol Immunol.

2018 Jan;93:38-46.

(IF 3.641)

1353. Wang Y, Cong W, Wu G, Ju X, Li Z, Duan X, Wang X, Gao H

.

MiR-376a suppresses the proliferation and invasion of non-small-cell lung cancer by targeting c-Myc.

Cell Biol Int.

2018 Jan;42(1):25-33.

(IF 2.571)

1354. Luo J, Xu Q, Jiang B, Zhang R, Jia X, Li X, Wang L, Guo C, Wu N, Shi D

.

Selectivity, cell permeability and oral availability studies of novel bromophenol derivative HPN as protein tyrosine phosphatase 1B inhibitor.

BRIT J PHARMACOL.

2018 Jan;175(1):140-153.

(IF 7.73)

1355. Wu YX, He HQ, Nie YJ, Ding YH, Sun L, Qian F

.

Protostemonine effectively attenuates lipopolysaccharide-induced acute lung injury in mice.

Acta Pharmacol Sin.

2018 Jan;39(1):85-96.

(IF 5.064)

1356. Zheng Q, Wang B, Gao J, Xin N, Wang W, Song X, Shao Y, Zhao C

.

CD155 knockdown promotes apoptosis via AKT/Bcl-2/Bax in colon cancer cells.

J Cell Mol Med.

2018 Jan;22(1):131-140.

(IF 4.486)

1357. Chen D, Pan D, Tang S, Tan Z, Zhang Y, Fu Y, Lü G, Huang Q

.

Administration of chlorogenic acid alleviates spinal cord injury via TLR4/NF‑κB and p38 signaling pathway anti‑inflammatory activity.

Mol Med Rep.

2018 Jan;17(1):1340-1346.

(IF 2.1)

1358. Qiao H, Zhu Z, Fang D, Sun Y, Kang C, Di L, Zhang L, Gao Y

.

Redox-triggered mitoxantrone prodrug micelles for overcoming multidrug-resistant breast cancer.

J Drug Target.

2018 Jan;26(1):75-85.

(IF 3.38)

1359. Zhang Z, Wang J, Li J, Wang X, Song W

.

MicroRNA-150 promotes cell proliferation, migration, and invasion of cervical cancer through targeting PDCD4.

Biomed Pharmacother.

2018 Jan;97:511-517.

(IF 4.545)

1360. Zhang X, Li J, Wang X, Wang Y, Hang R, Huang X, Tang B, Chu PK

.

Effects of copper nanoparticles in porous TiO2 coatings on bacterial resistance and cytocompatibility of osteoblasts and endothelial cells.

MAT SCI ENG C-MATER.

2018 Jan 1;82:110-120.

(IF 5.88)

1361. Tang F, Yang TL

.

MicroRNA-126 alleviates endothelial cells injury in atherosclerosis by restoring autophagic flux via inhibiting of PI3K/Akt/mTOR pathway.

BIOCHEM BIOPH RES CO.

2018 Jan 1;495(1):1482-1489.

(IF 2.985)

1362. Luan W, Zhou Z, Zhu Y, Xia Y, Wang J, Xu B

.

miR-137 inhibits glutamine catabolism and growth of malignant melanoma by targeting glutaminase.

BIOCHEM BIOPH RES CO.

2018 Jan 1;495(1):46-52.

(IF 2.985)

1363. Gao X, Zhao H, Diao C, Wang X, Xie Y, Liu Y, Han J, Zhang M

.

miR-455-3p serves as prognostic factor and regulates the proliferation and migration of non-small cell lung cancer through targeting HOXB5.

BIOCHEM BIOPH RES CO.

2018 Jan 1;495(1):1074-1080.

(IF 2.985)

1364. Han CH, Guan ZB, Zhang PX, Fang HL, Li L, Zhang HM, Zhou FJ, Mao YF, Liu WW

.

Oxidative stress induced necroptosis activation is involved in the pathogenesis of hyperoxic acute lung injury.

BIOCHEM BIOPH RES CO.

2018 Jan 15;495(3):2178-2183.

(IF 2.985)

1365. Yu P, Shen X, Yang W, Zhang Y, Liu C, Huang T

.

ZEB1 stimulates breast cancer growth by up-regulating hTERT expression.

BIOCHEM BIOPH RES CO.

2018 Jan 22;495(4):2505-2511.

(IF 2.985)

1366. Gao AM, Zhang XY, Hu JN, Ke ZP

.

Apigenin sensitizes hepatocellular carcinoma cells to doxorubic through regulating miR-520b/ATG7 axis.

CHEM-BIOL INTERACT.

2018 Jan 25;280:45-50.

(IF 3.723)

1367. Zhou W, Peng Z, Zhang C, Liu S, Zhang Y.

.

ILK-induced epithelial-mesenchymal transition promotes the invasive phenotype in adenomyosis.

BIOCHEM BIOPH RES CO.

2018 Jan 31. pii: S0006-291X(18)30213-4.

(IF 2.985)

1368. Huang H, Lv W, Chen Y, Zheng X, Hu Y, Wang R, Huang M, Tang H.

.

The Role of NADPH Oxidase in the Inhibition of Trichophyton rubrum by 420-nm Intense Pulsed Light.

Front Microbiol.

2018 Jan 9;8:2636.

(IF 4.235)

1369. Chen D, Xu T, Tu M, Xu J, Zhou C, Cheng L, Yang R, Yang T, Zheng W, He X, Deng R, Ge X, Li J, Song Z, Zhao J, Gu F.

.

Recapitulating X-Linked Juvenile Retinoschisis in Mouse Model by Knock-In Patient-Specific Novel Mutation.

Front Mol Neurosci.

2018 Jan 12;10:453.

(IF 4.057)

1370. Dong W, Lv H, Guo K, Wang T, Ouyang Y, Jin M, Zhang Y.

.

Classical Swine Fever Virus Infection and Its NS4A Protein Expression Induce IL-8 Production through MAVS Signaling Pathway in Swine Umbilical Vein Endothelial Cells.

Front Microbiol.

2018 Jan 12;8:2687.

(IF 4.235)

1371. Zhang Y, Zhang LH, Chen X, Zhang N, Li G.

.

Piceatannol attenuates behavioral disorder and neurological deficits in aging mice via activating the Nrf2 pathway.

Food Funct.

2018 Jan 24;9(1):371-378.

(IF 4.171)

1372. Jun Cheng, Tangting Chen, Pengyun Li, Jing Wen, Ningbo Pang, Liping Zhang, Liqun Wang.

.

Sodium tanshinone IIA sulfonate prevents lipopolysaccharide-induced inflammation via suppressing nuclear factor-κB signaling pathway in human umbilical vein endothelial cells.

Canadian Journal of Physiology and Pharmacology.

Volume 96, Number 1, January 2018.

(IF 2.041)

1373. Chengbo Liu, Ze Chen, Wen Li, Lisu Huang, Yongjun Zhang.

.

Vitamin D Enhances Alveolar Development in Antenatal Lipopolysaccharide-Treated Rats through the Suppression of Interferon-γ Production.

Front Immunol.

2018 Jan 5.

(IF 5.085)

1374. Cui S, Hang F, Liu X, Xu Z, Liu Z, Zhao J, Zhang H, Chen W.

.

Effect of acids produced from carbohydrate metabolism in cryoprotectants on the viability of freeze-dried Lactobacillus and prediction of optimal initial cell concentration.

J Biosci Bioeng.

2018 Jan 11. pii: S1389-1723(17)31020-4.

(IF 2.366)

1375. Shen YL, Shi YZ, Chen GG, Wang LL, Zheng MZ, Jin HF, Chen YY.

.

TNF-α induces Drp1-mediated mitochondrial fragmentation during inflammatory cardiomyocyte injury.

Int J Mol Med.

2018 Jan 15.

(IF 3.098)

1376. Fang WJ, Wang CJ, He Y, Zhou YL, Peng XD, Liu SK.

.

Resveratrol alleviates diabetic cardiomyopathy in rats by improving mitochondrial function through PGC-1α deacetylation.

Acta Pharmacol Sin.

2018 Jan;39(1):59-73.

(IF 5.064)

1377. Li H, Chen LP, Wang T, Wang SG, Liu JH.

.

Calpain inhibition improves erectile function in diabetic mice via upregulating endothelial nitric oxide synthase expression and reducing apoptosis.

Asian J Androl.

2018 Jan 9.

(IF 2.448)

1378. Yuan Q, Yu H, Chen J, Song X, Sun L.

.

Knockdown of pyruvate kinase type M2 suppresses tumor survival and invasion in osteosarcoma cells both in vitro and in vivo.

Exp Cell Res.

2018 Jan 1;362(1):209-216.

(IF 3.383)

1379. Zhang L, Feng Q, Wang T.

.

Necrostatin-1 Protects Against Paraquat-Induced Cardiac Contractile Dysfunction via RIP1-RIP3-MLKL-Dependent Necroptosis Pathway.

Cardiovasc Toxicol.

2018 Jan 3.

(IF 2.284)

1380. Hou WL, Yin J, Alimujiang M, Yu XY, Ai LG, Bao YQ, Liu F, Jia WP

.

Inhibition of mitochondrial complex I improves glucose metabolism independently of AMPK activation.

J Cell Mol Med.

2018 Feb;22(2):1316-1328.

(IF 4.486)

1381. Zhang Z, Wang J, Wang X, Song W, Shi Y, Zhang L

.

MicroRNA-21 promotes proliferation, migration, and invasion of cervical cancer through targeting TIMP3.

Arch Gynecol Obstet.

2018 Feb;297(2):433-442.

(IF 2.283)

1382. Zhou L, Chen X, Liu T, Zhu C, Si M, Jargstorf J, Li M, Pan G, Gong Y, Luo ZP, Yang H, Pei M, He F

.

SIRT1-dependent anti-senescence effects of cell-deposited matrix on human umbilical cord mesenchymal stem cells.

J TISSUE ENG REGEN M.

2018 Feb;12(2):e1008-e1021.

(IF 3.078)

1383. Zai W, Chen W, Luan J, Fan J, Zhang X, Wu Z, Ding T, Ju D, Liu H

.

Dihydroquercetin ameliorated acetaminophen-induced hepatic cytotoxicity via activating JAK2/STAT3 pathway and autophagy.

APPL MICROBIOL BIOT.

2018 Feb;102(3):1443-1453.

(IF 3.53)

1384. Zhao C, Yang C, Chen M, Lv X, Liu B, Yi L, Cornara L, Wei MC, Yang YC, Tundis R, Xiao J

.

Regulatory Efficacy of Brown Seaweed Lessonia nigrescens Extract on the Gene Expression Profile and Intestinal Microflora in Type 2 Diabetic Mice.

Mol Nutr Food Res.

2018 Feb;62(4).

(IF 5.309)

1385. Liu XX, Zhang XW, Wang K, Wang XY, Ma WL, Cao W, Mo D, Sun Y, Li XQ

.

Kuwanon G attenuates atherosclerosis by upregulation of LXRα-ABCA1/ABCG1 and inhibition of NFκB activity in macrophages.

TOXICOL APPL PHARM .

2018 Feb 15;341:56-63.

(IF 3.616)

1386. Li Q, Huang Q, Huyan T, Wang Y, Huang Q, Shi J

.

Bifacial effects of engineering tumour cell-derived exosomes on human natural killer cells.

Exp Cell Res.

2018 Feb 15;363(2):141-150.

(IF 3.383)

1387. Song Z, Feng C, Lu Y, Lin Y, Dong C

.

PHGDH is an independent prognosis marker and contributes cell proliferation, migration and invasion in human pancreatic cancer.

Gene.

2018 Feb 5;642:43-50.

(IF 2.984)

1388. Cheng Y, Zhang D, Zhu M, Wang Y, Guo S, Xu B, Hou G, Feng Y, Liu G.

.

Liver X receptor α is targeted by microRNA-1 to inhibit cardiomyocyte apoptosis through a ROS-mediated mitochondrial pathway.

Biochem Cell Biol.

2018 Feb;96(1):11-18.

(IF 2.46)

1389. Duan D, Wang H, Zhou R, Jiang Q, Xiao R.

.

The PR-1 domain accounts for the anti-angiogenic activity of a cysteine-rich secretory protein member from the buccal glands of Lampetra japonica.

Int J Biol Macromol.

2018 Feb;107(Pt B):2102-2112.

(IF 5.162)

1390. Liang J, Chen S, Hu Y, Yang Y, Yuan J, Wu Y, Li S, Lin J, He L, Hou S, Zhou L, Huang S.

.

Protective roles and mechanisms of Dendrobium officinal polysaccharides on secondary liver injury in acute colitis.

Int J Biol Macromol.

2018 Feb;107(Pt B):2201-2210.

(IF 5.162)

1391. Tian Y, Heng D, Xu K, Liu W, Weng X, Hu X, Zhang C.

.

cGMP/PKG-I Pathway-Mediated GLUT1/4 Regulation by NO in Female Rat Granulosa Cells.

Endocrinology.

2018 Feb 1;159(2):1147-1158.

(IF 3.934)

1392. Hao Zhang, Ping Wang, Yixue Xue, Libo Liu, Zhen Li, Yunhui Liu.

.

Allicin ameliorates cognitive impairment in APP/PS1 mice via Suppressing oxidative stress by Blocking JNK Signaling Pathways.

TISSUE CELL.

Volume 50, February 2018, Pages 89-95.

(IF 1.837)

1393. Dong K, Yang C, Yan Y, Wang P, Sun Y, Wang K, Lu T, Chen Q, Zhang Y, Xing J, Dong Y

.

Investigation of the intracellular oxidative stress amplification, safety and anti-tumor effect of a kind of novel redox-responsive micelle.

J Mater Chem B.

2018 Feb 21 6(7):1105-1117.

(IF 5.344)

1394. Wu XL, Wang LK, Yang DD, Qu M, Yang YJ, Guo F, Han L, Xue J.

.

Effects of Glut1 gene silencing on proliferation, differentiation, and apoptosis of colorectal cancer cells by targeting the TGF-β/PI3K-AKT-mTOR signaling pathway.

J Cell Biochem.

2018 Feb;119(2):2356-2367.

(IF 4.237)

1395. Lu QC, Rui ZH, Guo ZL, Xie W, Shan S, Ren T

.

LncRNA-DANCR contributes to lung adenocarcinoma progression by sponging miR-496 to modulate mTOR expression.

J Cell Mol Med.

2018 Mar;22(3):1527-1537.

(IF 4.486)

1396. Luan W, Zhou Z, Ni X, Xia Y, Wang J, Yan Y, Xu B

.

Long non-coding RNA H19 promotes glucose metabolism and cell growth in malignant melanoma via miR-106a-5p/E2F3 axis.

J CANCER RES CLIN.

2018 Mar;144(3):531-542.

(IF 3.656)

1397. Qin Y, Sun W, Zhang H, Zhang P, Wang Z, Dong W, He L, Zhang T, Shao L, Zhang W, Wu C

.

LncRNA GAS8-AS1 inhibits cell proliferation through ATG5-mediated autophagy in papillary thyroid cancer.

Endocrine.

2018 Mar;59(3):555-564.

(IF 3.235)

1398. Chang G, Liu J, Qin S, Jiang Y, Zhang P, Yu H, Lu K, Zhang N, Cao L, Wang Y, Li Y, Zhang D

.

Cardioprotection by exenatide: A novel mechanism via improving mitochondrial function involving the GLP-1 receptor/cAMP/PKA pathway.

Int J Mol Med.

2018 Mar;41(3):1693-1703.

(IF 3.098)

1399. Wan L, Yuan X, Liu M, Xue B

.

miRNA-223-3p regulates NLRP3 to promote apoptosis and inhibit proliferation of hep3B cells.

Exp Ther Med.

2018 Mar;15(3):2429-2435.

(IF 1.785)

1400. Zhu C, Huang Q, Zhu H

.

Melatonin Inhibits the Proliferation of Gastric Cancer Cells Through Regulating the miR-16-5p-Smad3 Pathway.

DNA Cell Biol.

2018 Mar;37(3):244-252.

(IF 3.191)

1401. Qiao Y, Xu L, Tao X, Yin L, Qi Y, Xu Y, Han X, Tang Z, Ma X, Liu K, Peng J

.

Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.

Toxicol Lett.

2018 Mar 1;284:37-45.

(IF 3.569)

1402. Wang Y, Xu J, Liu Y, Li Z, Li X

.

TLR4-NF-κB Signal Involved in Depressive-Like Behaviors and Cytokine Expression of Frontal Cortex and Hippocampus in Stressed C57BL/6 and ob/ob Mice.

Neural Plast.

2018 Mar 22;2018:7254016.

(IF 3.093)

1403. Yang LL, Zhao Y, Luo SM, Ma JY, Ge ZJ, Shen W, Yin S.

.

Toxic effects and possible mechanisms of hydrogen sulfide and/or ammonia on porcine oocyte maturation in vitro.

Toxicol Lett.

2018 Mar 15;285:20-26.

(IF 3.569)

1404. Jianxiang Gan, Weichun Qian, Song Lin.

.

Umbelliferone Alleviates Myocardial Ischemia: the Role of Inflammation and Apoptosis.

Inflammation.

March 2018, Volume 41, Issue 2, pp 464–473.

(IF 3.212)

1405. Yan F, Wang C, Li T, Cai W, Sun J.

.

Role of miR-21 in the growth and metastasis of human salivary adenoid cystic carcinoma.

Mol Med Rep.

2018 Mar 17(3):4237-4244.

(IF 2.1)

1406. Gu L, Lu LS, Zhou DL, Liu ZC

.

UCA1 promotes cell proliferation and invasion of gastric cancer by targeting CREB1 sponging to miR-590-3p.

CANCER MED-US.

2018 Apr;7(4):1253-1263.

(IF 3.491)

1407. Qin J, Ning H, Zhou Y, Hu Y, Huang B, Wu Y, Huang R

.

LncRNA Uc.173 is a key molecule for the regulation of lead-induced renal tubular epithelial cell apoptosis.

Biomed Pharmacother.

2018 Apr;100:101-107.

(IF 4.545)

1408. Lin C, Xie L, Lu Y, Hu Z, Chang J

.

miR-133b reverses cisplatin resistance by targeting GSTP1 in cisplatin-resistant lung cancer cells.

Int J Mol Med.

2018 Apr;41(4):2050-2058.

(IF 3.098)

1409. Zhai D, Cui C, Xie L, Cai L, Yu J

.

Sterol regulatory element-binding protein 1 cooperates with c-Myc to promote epithelial-mesenchymal transition in colorectal cancer.

Oncol Lett.

2018 Apr;15(4):5959-5965.

(IF 2.311)

1410. Yang J, Ren X, Zhang L, Li Y, Cheng B, Xia J

.

Oridonin inhibits oral cancer growth and PI3K/Akt signaling pathway.

Biomed Pharmacother.

2018 Apr;100:226-232.

(IF 4.545)

1411. Zheng R, Lin S, Guan L, Yuan H, Liu K, Liu C, Ye W, Liao Y, Jia J, Zhang R

.

Long non-coding RNA XIST inhibited breast cancer cell growth, migration, and invasion via miR-155/CDX1 axis.

BIOCHEM BIOPH RES CO.

2018 Apr 15;498(4):1002-1008.

(IF 2.985)

1412. Jin X, Wei Y, Xu F, Zhao M, Dai K, Shen R, Yang S, Zhang N

.

SIRT1 promotes formation of breast cancer through modulating Akt activity.

J Cancer.

2018 Apr 30;9(11):2012-2023.

(IF 3.565)

1413. Shen Y, Yan Y, Lu L, Qian Y, Guan X, Zhang L, Qi Y, Gu L, Ding F.

.

Klotho ameliorates hydrogen peroxide-induced oxidative injury in TCMK-1 cells.

Int Urol Nephrol.

2018 Apr;50(4):787-798.

(IF 1.843)

1414. Fan S, Fan C, Liu N, Huang K, Fang X, Wang K

.

Downregulation of the long non-coding RNA ZFAS1 is associated with cell proliferation, migration and invasion in breast cancer.

Mol Med Rep.

2018 May;17(5):6405-6412.

(IF 2.1)

1415. Wang CH, Li YH, Tian HL, Bao XX, Wang ZM

.

Long non-coding RNA BLACAT1 promotes cell proliferation, migration and invasion in cervical cancer through activation of Wnt/β-catenin signaling pathway.

EUR REV MED PHARMACO.

2018 May;22(10):3002-3009.

(IF 3.024)

1416. Yao H, Tao X, Xu L, Qi Y, Yin L, Han X, Xu Y, Zheng L, Peng J

.

Dioscin alleviates non-alcoholic fatty liver disease through adjusting lipid metabolism via SIRT1/AMPK signaling pathway.

Pharmacol Res.

2018 May;131:51-60.

(IF 5.893)

1417. Cheng Q, Xu X, Jiang H, Xu L, Li Q

.

Knockdown of long non-coding RNA XIST suppresses nasopharyngeal carcinoma progression by activating miR-491-5p.

J Cell Biochem.

2018 May;119(5):3936-3944.

(IF 4.237)

1418. Li H, Sun J, Du J, Wang F, Fang R, Yu C, Xiong J, Chen W, Lu Z, Liu J

.

Clostridium butyricum exerts a neuroprotective effect in a mouse model of traumatic brain injury via the gut-brain axis.

NEUROGASTROENT MOTIL.

2018 May;30(5):e13260.

(IF 2.946)

1419. Hou L, Gan F, Zhou X, Zhou Y, Qian G, Liu Z, Huang K

.

Immunotoxicity of ochratoxin A and aflatoxin B1 in combination is associated with the nuclear factor kappa B signaling pathway in 3D4/21 cells.

Chemosphere.

2018 May;199:718-727.

(IF 5.778)

1420. Zhou W, Chen X, Hu Q, Chen X, Chen Y, Huang L

.

Galectin-3 activates TLR4/NF-κB signaling to promote lung adenocarcinoma cell proliferation through activating lncRNA-NEAT1 expression.

BMC Cancer.

2018 May 22;18(1):580.

(IF 3.15)

1421. Wu Z, Lu B, Li X, Miao W, Li J, Shi Y, Yu W.

.

MicroRNA-26a inhibits proliferation and tumorigenesis via targeting CKS2 in laryngeal squamous cell carcinoma.

CLIN EXP PHARMACOL P .

2018 May;45(5):444-451.

(IF 2.092)

1422. Bo Zhou, Min Wen, Xin Lin, Yun-Hua Chen, Yun Gou, Yong Li, Yi Zhang, Hong-Wei Li, Lei Tang.

.

Alpha Lipoamide Ameliorates Motor Deficits and Mitochondrial Dynamics in the Parkinson’s Disease Model Induced by 6-Hydroxydopamine.

Neurotoxicity Research.

May 2018, Volume 33, Issue 4, pp 759–767.

(IF 3.311)

1423. Zhao L, Tao X, Qi Y, Xu L, Yin L, Peng J

.

Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress.

Redox Biol.

2018 Jun;16:189-198.

(IF 9.986)

1424. Li J, Zhou L

.

Overexpression of lncRNA DANCR positively affects progression of glioma via activating Wnt/β-catenin signaling.

Biomed Pharmacother.

2018 Jun;102:602-607.

(IF 4.545)

1425. Zhu C, Song K, Shen Z, Quan Y, Tan B, Luo W, Wu S, Tang K, Yang Z, Wang X

.

Roseburia intestinalis inhibits interleukin‑17 excretion and promotes regulatory T cells differentiation in colitis.

Mol Med Rep.

2018 Jun;17(6):7567-7574.

(IF 2.1)

1426. Zhu K, He Q, Li L, Zhao Y, Zhao J.

.

Silencing thioredoxin1 exacerbates damage of astrocytes exposed to OGD/R by aggravating apoptosis through the Actin-Ras2-cAMP-PKA pathway.

Int J Neurosci.

2018 Jun;128(6):512-519.

(IF 2.107)

1427. Wansong Zhang, Cheng Yang, Wenbin Guo, Xiaobin Guo, Jun Bian, Qizhao Zhou, Mingkun Chen, Junhao Zhou, Zijian Chen, Peng Wang, Xianyuan Lv, Zhuoyu Xiao, Cundong Liu

.

[rotective effect of bone marrow mesenchymal stem cells-derived exosomes against testicular ischemia-reperfusion injury in rats]

Nan Fang Yi Ke Da Xue Xue Bao.

2018 Jul 30;38(8):910-916. doi: 10.3969/j.issn.1673-4254.2018.08.02.

1428. Han M, Gao H, Ju P, Gao MQ, Yuan YP, Chen XH, Liu KL, Han YT, Han ZW

.

Hispidulin inhibits hepatocellular carcinoma growth and metastasis through AMPK and ERK signaling mediated activation of PPARγ.

Biomed Pharmacother.

2018 Jul;103:272-283.

(IF 4.545)

1429. Xu B, Zhang W, Chen Y, Xu Y, Wang B, Zong L

.

Eudragit® L100-coated mannosylated chitosan nanoparticles for oral protein vaccine delivery.

Int J Biol Macromol.

2018 Jul 1;113:534-542.

(IF 5.162)

1430. Wu ZH, Lin C, Liu CC, Jiang WW, Huang MZ, Liu X, Guo WJ

.

MiR-616-3p promotes angiogenesis and EMT in gastric cancer via the PTEN/AKT/mTOR pathway.

BIOCHEM BIOPH RES CO.

2018 Jul 2;501(4):1068-1073.

(IF 2.985)

1431. Teng Y, Feng C, Liu Y, Jin H, Gao Y, Li T

.

Anti-inflammatory effect of tranexamic acid against trauma-hemorrhagic shock-induced acute lung injury in rats.

EXP ANIM TOKYO.

2018 Jul 30;67(3):313-320.

(IF 1.574)

1432. Liao X, Song L, Zhang L, Wang H, Tong Q, Xu J, Yang G, Yang S, Zheng H.

.

LAMP3 regulates hepatic lipid metabolism through activating PI3K/Akt pathway.

Mol Cell Endocrinol.

2018 Jul 15;470:160-167.

(IF 3.871)

1433. Xiaoyan Tan, Haiying Tang, Jian Bi, Na Li, Yujie Jia.

.

MicroRNA‐222‐3p associated with Helicobacter pylori targets HIPK2 to promote cell proliferation, invasion, and inhibits apoptosis in gastric cancer.

journal of cellular biochemistry.

Volume119, Issue7, July 2018, Pages 5153-5162.

(IF 3.448)

1434. Yu HT, Fu XY, Liang B, Wang S, Liu JK, Wang SR, Feng ZH

.

Oxidative damage of mitochondrial respiratory chain in different organs of a rat model of diet-induced obesity.

Eur J Nutr.

2018 Aug;57(5):1957-1967.

(IF 4.664)

1435. Zhang Z, Ke M, Qu Q, Peijnenburg WJGM, Lu T, Zhang Q, Ye Y, Xu P, Du B, Sun L, Qian H

.

Impact of copper nanoparticles and ionic copper exposure on wheat (Triticum aestivum L.) root morphology and antioxidant response.

Environ Pollut.

2018 Aug;239:689-697.

(IF 6.792)

1436. Cheng H, Sun X, Li J, He P, Liu W, Meng X

.

Knockdown of Uba2 inhibits colorectal cancer cell invasion and migration through downregulation of the Wnt/β-catenin signaling pathway.

J Cell Biochem.

2018 Aug;119(8):6914-6925.

(IF 4.237)

1437. Zhao X, Wu X, Qian M, Song Y, Wu D, Zhang W

.

Knockdown of TGF-β1 expression in human umbilical cord mesenchymal stem cells reverts their exosome-mediated EMT promoting effect on lung cancer cells.

Cancer Lett.

2018 Aug 1;428:34-44.

(IF 7.36)

1438. Hui Y, Yin Y

.

MicroRNA-145 attenuates high glucose-induced oxidative stress and inflammation in retinal endothelial cells through regulating TLR4/NF-κB signaling.

Life Sci.

2018 Aug 15;207:212-218.

(IF 3.647)

1439. Huang X, Wang Z, Li D, Huang Z, Dong X, Li C, Lan J

.

Study of microRNAs targeted Dvl2 on the osteoblasts differentiation of rat BMSCs in hyperlipidemia environment.

J Cell Physiol.

2018 Sep;233(9):6758-6766.

(IF 5.546)

1440. Xu T, Pan LX, Ge YX, Li P, Meng XM, Huang C, Li J.

.

TMEM88 mediates inflammatory cytokines secretion by regulating JNK/P38 and canonical Wnt/β-catenin signaling pathway in LX-2 cells.

Inflammopharmacology.

2018 Oct;26(5):1339-1348.

(IF 3.238)

1441. Shi H, Wang J, Wang J, Huang Z, Yang Z.

.

IL-17A induces autophagy and promotes microglial neuroinflammation through ATG5 and ATG7 in intracerebral hemorrhage.

J Neuroimmunol.

2018 Oct 15;323:143-151.

(IF 3.125)

1442. Xiao Q, Piao R, Wang H, Li C, Song L

.

Orientin-mediated Nrf2/HO-1 signal alleviates H2O2-induced oxidative damage via induction of JNK and PI3K/AKT activation.

Int J Biol Macromol.

2018 Oct 15;118(Pt A):747-755.

(IF 5.162)

1443. Jin X, Aimaiti Y, Chen Z, Wang W, Li D

.

Hepatic stellate cells promote angiogenesis via the TGF-β1-Jagged1/VEGFA axis.

Exp Cell Res.

2018 Dec 15;373(1-2):34-43.

(IF 3.383)

1444. Wu J, Ni Y, Wang X, Yang Q, Mao J, Tong J, Zhang J, An Y

.

Role of mitochondrial DNA in oxidative damage induced by sodium arsenite in human bronchial epithelial cells.

J Toxicol Environ Health A.

2019 82(18):990-996.

1445. Shentu YP, Hu WT, Liang JW, Liuyang ZY, Wei H, Qun W, Wang XC, Wang JZ, Westermarck J, Liu R

.

Genistein Decreases APP/tau Phosphorylation and Ameliorates Aβ Overproduction Through Inhibiting CIP2A.

Curr Alzheimer Res.

2019 16(8):732-740.

(IF 3.047)

1446. Shang X, Niu X, Wang R, Li Z, Hao X, Liu X, Shao J, Han L, Li Y

.

Effect of Taurine on Alterations in Deiodinase 3 Expression Induced by BDE 209 in Human Neuroblasoma-Derived SK-N-AS Cells.

Adv Exp Med Biol.

2019 1155:847-856.

(IF 2.45)

1447. Qiu M, Zhang S, Ke L, Tang H, Zeng X, Liu J

.

JS-K enhances chemosensitivity of prostate cancer cells to Taxol via reactive oxygen species activation.

Oncol Lett.

2019 Jan 17(1):757-764.

(IF 2.311)

1448. Cui B, Zhang S, Wang Y, Guo Y

.

Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line.

Biomed Pharmacother.

2019 Jan 109:112-119.

(IF 4.545)

1449. Ran S, Chu M, Gu S, Wang J, Liang J

.

Enterococcus faecalis induces apoptosis and pyroptosis of human osteoblastic MG63 cells via the NLRP3 inflammasome.

Int Endod J.

2019 Jan 52(1):44-53.

(IF 3.801)

1450. Su QQ, Tian YY, Liu ZN, Ci LL, Lv XW

.

Purinergic P2X7 receptor blockade mitigates alcohol-induced steatohepatitis and intestinal injury by regulating MEK1/2-ERK1/2 signaling and egr-1 activity.

Int Immunopharmacol.

2019 Jan 66:52-61.

(IF 3.943)

1451. Zhao Y, Yan S, Chen L, Shi B, Guo X

.

Effect of interaction between leucine and acetate on the milk protein synthesis in bovine mammary epithelial cells.

Anim Sci J.

2019 Jan 90(1):81-89.

(IF 1.399)

1452. Shi B, Li S, Ju H, Liu X, Li D, Li Y

.

Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats.

Life Sci.

2019 Jan 1 216:85-91.

(IF 3.647)

1453. Wang S, Luo Q, Fan P

.

Cannabisin F from Hemp (Cannabis sativa) Seed Suppresses Lipopolysaccharide-Induced Inflammatory Responses in BV2 Microglia as SIRT1 Modulator.

Int J Mol Sci.

2019 Jan 25 20(3). pii: E507.

(IF 4.556)

1454. Du X, Zhang P, Fu H, Ahsan HM, Gao J, Chen Q

.

Smart mitochondrial-targeted cancer therapy: Subcellular distribution, selective TrxR2 inhibition accompany with declined antioxidant capacity.

INT J PHARMACOL.

2019 Jan 30 555:346-355.

(IF 0.692)

1455. Yang H, Wang C, Zhang L, Lv J, Ni H

.

Rutin alleviates hypoxia/reoxygenation-induced injury in myocardial cells by up-regulating SIRT1 expression.

CHEM-BIOL INTERACT.

2019 Jan 5 297:44-49.

(IF 3.723)

1456. Xin Hu, Xiaofang Wu, Bo Zhao, Yongyi Wang

.

Scutellarin Protects Human Retinal Pigment Epithelial Cells Against Hydrogen Peroxide (H 2 O 2)-induced Oxidative Damage

Cell Biosci.

2019 Jan 21;9:12. doi: 10.1186/s13578-019-0276-0.

(IF 5.026)

1457. Cao FJ, Xu MX, Zhou BH, Du YS, Yao JH, Zhou L

.

Effects of 2-aryl-1-cyano-1,2,3,4-tetrohydroisoquinolines on apoptosis induction mechanism in NB4 and MKN-45 cells.

Toxicol In Vitro.

2019 Feb 54:295-303.

(IF 2.959)

1458. Zhai J, Qu X, Zhang Y, Gao H, Tao L, Song Y, Zhang S

.

Salvianolic acid inhibits the effects of high glucose on vascular endothelial dysfunction by modulating the Sirt1-eNOS pathway.

J BIOCHEM MOL TOXIC.

2019 Feb 33(2):e22245.

(IF 3.606)

1459. Sun Z, Li Q, Hou R, Sun H, Tang Q, Wang H, Hao Z, Kang S, Xu T, Wu S

.

Kaempferol-3-O-glucorhamnoside inhibits inflammatory responses via MAPK and NF-κB pathways in vitro and in vivo.

TOXICOL APPL PHARM .

2019 Feb 1 364:22-28.

(IF 3.616)

1460. Wang K, Hu S, Wang B, Wang J, Wang X, Xu C

.

Genistein protects intervertebral discs from degeneration via Nrf2-mediated antioxidant defense system: An in vitro and in vivo study.

J Cell Physiol.

2019 Feb 18

(IF 5.546)

1461. Wang L, Yan W, Wang J

.

Silencing MEKK3 attenuates cardiomyocyte injury caused by hypoxia/reoxygenation via the sonic hedgehog pathway.

J Cell Physiol.

2019 Feb 3

(IF 5.546)

1462. Zhang Y, Zhang J, Wu C, Guo S, Su J, Zhao W, Xing H

.

Higenamine protects neuronal cells from oxygen-glucose deprivation/reoxygenation-induced injury.

J Cell Biochem.

2019 Mar 120(3):3757-3764.

(IF 4.237)

1463. Hu X, Liang Y, Zhao B, Wang Y

.

Thymoquinone protects human retinal pigment epithelial cells against hydrogen peroxide induced oxidative stress and apoptosis.

J Cell Biochem.

2019 Mar 120(3):4514-4522.

(IF 4.237)

1464. Li C, Wang Y, Li L, Han Z, Mao S, Wang G

.

Betaine protects against heat exposure-induced oxidative stress and apoptosis in bovine mammary epithelial cells via regulation of ROS production.

CELL STRESS CHAPERON.

2019 Mar 24(2):453-460.

(IF 2.892)

1465. Wei R, Ye X, Zhao Y, Jia N, Liu T, Lian W, Wei H, Zhang G, Song L

.

MicroRNA-218 inhibits the cell proliferation and migration in clear cell renal cell carcinoma through targeting cancerous inhibitor of protein phosphatase 2A.

Oncol Lett.

2019 Mar 17(3):3211-3218.

(IF 2.311)

1466. Wang Y, Zhang M, Li Z, Yue J, Xu M, Zhang Y, Yung KKL, Li R

.

Fine particulate matter induces mitochondrial dysfunction and oxidative stress in human SH-SY5Y cells.

Chemosphere.

2019 Mar 218:577-588.

(IF 5.778)

1467. Cao Q, He Z, Sun WQ, Fan G, Zhao J, Bao N, Ye T

.

Improvement of calcium phosphate scaffold osteogenesis in vitro via combination of glutamate-modified BMP-2 peptides.

MAT SCI ENG C-MATER.

2019 Mar 96:412-418.

(IF 5.88)

1468. Liang X, Zhang L, Ji Q, Wang B, Wei D, Cheng D

.

miR-421 promotes apoptosis and suppresses metastasis of osteosarcoma cells via targeting LTBP2.

J Cell Biochem.

2019 Mar 28

(IF 4.237)

1469. Zhai N, Liu K, Li H, Liu Z, Wang H, Korolchuk VI, Carroll B, Pan C, Gan F, Huang K, Chen X

.

PCV2 replication promoted by oxidative stress is dependent on the regulation of autophagy on apoptosis.

Vet Res.

2019 Mar 5 50(1):19.

(IF 3.357)

1470. Li Y, Liu X, Du A, Zhu X, Yu B

.

miR-203 accelerates apoptosis and inflammation induced by LPS via targeting NFIL3 in cardiomyocytes.

J Cell Biochem.

2019 Apr 120(4):6605-6613.

(IF 4.237)

1471. Wu B, Wu X, Liu S, Wang Z, Chen L

.

Size-dependent effects of polystyrene microplastics on cytotoxicity and efflux pump inhibition in human Caco-2 cells.

Chemosphere.

2019 Apr 221:333-341.

(IF 5.778)

1472. Wang QL, Guo C, Qi J, Ma JH, Liu FY, Lin SQ, Zhang CY, Xie WD, Zhuang JJ, Li X

.

Protective effects of 3β-angeloyloxy-8β, 10β-dihydroxyeremophila-7(11)-en-12, 8α-lactone on paraquat-induced oxidative injury in SH-SY5Y cells.

J Asian Nat Prod Res.

2019 Apr 21(4):364-376.

(IF 1.345)

1473. Nie Y, Yu K, Li B, Hu Y, Zhang H, Xin R, Xiong Y, Zhao P, Chai G

.

S-allyl-l-cysteine attenuates bleomycin-induced pulmonary fibrosis and inflammation via AKT/NF-κB signaling pathway in mice.

J Pharmacol Sci.

2019 Apr 139(4):377-384.

(IF 2.835)

1474. Liu J, Giri BR, Chen Y, Cheng G

.

14-3-3 protein and ubiquitin C acting as SjIAP interaction partners facilitate tegumental integrity in Schistosoma japonicum.

Int J Parasitol.

2019 Apr 49(5):355-364.

(IF 3.53)

1475. Chen RR, Fan XH, Chen G, Zeng GW, Xue YG, Liu XT, Wang CY

.

Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/ TGFβ1/Smad2/3 signaling axis.

CHEM-BIOL INTERACT.

2019 Apr 1 302:11-21.

(IF 3.723)

1476. Bai K, Jiang L, Zhu S, Feng C, Zhao Y, Zhang L, Wang T

.

Dimethylglycine sodium salt protects against oxidative damage and mitochondrial dysfunction in the small intestines of mice.

Int J Mol Med.

2019 May 43(5):2199-2211.

(IF 3.098)

1477. Zhang C, Dai J, Fan Y, He X, Wei R

.

MicroRNA-16 inhibits cell proliferation and migration by targeting heat shock protein 70 in heat-denatured dermal fibroblasts.

Korean J Intern Med.

2019 May 34(3):634-642.

(IF 2.751)

1478. Li G, Zhu Y

.

Effect of lncRNA ANRIL knockdown on proliferation and cisplatin chemoresistance of osteosarcoma cells in vitro.

Pathol Res Pract.

2019 May 215(5):931-938.

(IF 2.05)

1479. Liu J, Du W

.

LncRNA FENDRR attenuates colon cancer progression by repression of SOX4 protein.

ONCOTARGETS THER.

2019 May 30 12:4287-4295.

(IF 3.337)

1480. Hu T, Linghu K, Huang S, Battino M, Georgiev MI, Zengin G, Li D, Deng Y, Wang YT, Cao H.

.

Flaxseed extract induces apoptosis in human breast cancer MCF-7 cells.

Food Chem Toxicol.

2019 May 127:188-196.

(IF 4.679)

1481. Guo Q, Liu S, Wang S, Wu M, Li Z, Wang Y.

.

Beta-hydroxybutyric acid attenuates neuronal damage in epileptic mice.

Acta Histochem.

2019 May 121(4):455-459.

(IF 2.107)

1482. Fu S, Ni S, Wang D, Fu M, Hong T

.

Berberine suppresses mast cell-mediated allergic responses via regulating FcɛRI-mediated and MAPK signaling.

Int Immunopharmacol.

2019 Jun 71:1-6.

(IF 3.943)

1483. Wei L, Qin Y, Jiang L, Yu X, Xi Z

.

PPARγ and mitophagy are involved in hypoxia/reoxygenation-induced renal tubular epithelial cells injury.

J RECEPT SIG TRANSD.

2019 Jun 39(3):235-242.

(IF 1.466)

1484. Zhu Z, Yu J, Lin W, Tang H, Zhang W, Lu B

.

Molecular hydrogen accelerates the reversal of acute obstructive cholangitis‑induced liver dysfunction by restoring gap and tight junctions.

Mol Med Rep.

2019 Jun 19(6):5177-5184.

(IF 2.1)

1485. Lou R, Cao H, Dong S, Shi C, Xu X, Ma R, Wu J, Feng J

.

Liver X receptor agonist T0901317 inhibits the migration and invasion of non-small-cell lung cancer cells in vivo and in vitro.

ANTI-CANCER DRUG.

2019 Jun 30(5):495-500.

(IF 2.26)

1486. Han D, Gu X, Gao J, Wang Z, Liu G, Barkema HW, Han B

.

Chlorogenic acid promotes the Nrf2/HO-1 anti-oxidative pathway by activating p21Waf1/Cip1 to resist dexamethasone-induced apoptosis in osteoblastic cells.

FREE RADICAL BIO MED.

2019 Jun 137:1-12.

(IF 6.17)

1487. Deng W, Duan M, Qian B, Zhu Y, Lin J, Zheng L, Zhang C, Qi X, Luo M

.

NADPH oxidase 1/4 inhibition attenuates the portal hypertensive syndrome via modulation of mesenteric angiogenesis and arterial hyporeactivity in rats.

CLIN RES HEPATOL GAS.

2019 Jun 43(3):255-265.

(IF 2.718)

1488. Liu D, Li S, Gong L, Yang Y, Han Y, Xie M, Zhang C

.

Suppression of microRNA-141 suppressed p53 to protect against neural apoptosis in epilepsy by SIRT1 expression.

J Cell Biochem.

2019 Jun 120(6):9409-9420.

(IF 4.237)

1489. Liu Y, Han J, Zhou Z, Li D

.

Paeoniflorin protects pancreatic β cells from STZ-induced damage through inhibition of the p38 MAPK and JNK signaling pathways.

Eur J Pharmacol.

2019 Jun 15 853:18-24.

(IF 3.263)

1490. Zhang WY, Hu XF, Wan N, Zhang JF, Yang P, Wen Q, Chen WJ, Zhu F, Liang ML, Cheng LX, Shu YW

.

Protective effect of the glucagon-like peptide-1 analogue liraglutide on carbon tetrachloride-induced acute liver injury in mice.

BIOCHEM BIOPH RES CO.

2019 Jun 25 514(2):386-392.

(IF 2.985)

1491. Shen L, Lei S, Huang L, Li S, Yi S, Breitzig M, Huang M, Mo X, Sun H, Zheng Q, Tian J, Czachor A, Wang F

.

Therapeutic effects of the rhSOD2-Hirudin fusion protein on bleomycin-induced pulmonary fibrosis in mice.

Eur J Pharmacol.

2019 Jun 5 852:77-89.

(IF 3.263)

1492. Tang CL, Yang JF, Pan Q, Zhang RH, Xie YP, Xiong Y, Zhou HH

.

Anti-CTLA-4 monoclonal antibody improves efficacy of the glyceraldehyde-3-phosphate dehydrogenase protein vaccine against Schistosoma japonicum in mice.

Parasitol Res.

2019 Jul 118(7):2287-2293.

(IF 1.641)

1493. Yang Q, Zhu Z, Wang L, Xia H, Mao J, Wu J, Kato K, Li H, Zhang J, Yamanaka K, An Y

.

The protective effect of silk fibroin on high glucose induced insulin resistance in HepG2 cells.

ENVIRON TOXICOL CHEM.

2019 Jul 69:66-71.

(IF 3.152)

1494. He ZB, Duan GF, Liang CY, Li HY, Liu JS, Yang WD

.

Up-regulation of Nrf2-dependent antioxidant defenses in Perna viridis after exposed to Prorocentrum lima.

FISH SHELLFISH IMMUN.

2019 Jul 90:173-179.

(IF 3.298)

1495. Pu Y, Liu Z, Tian H, Bao Y

.

The immunomodulatory effect of Poria cocos polysaccharides is mediated by the Ca2+/PKC/p38/NF-κB signaling pathway in macrophages.

Int Immunopharmacol.

2019 Jul 72:252-257.

(IF 3.943)

1496. Zou P, Ji HM, Zhao JW, Ding XM, Zhen ZG, Zhang X, Nie XQ, Xue LX

.

Protective effect of isoliquiritigenin against cerebral injury in septic mice via attenuation of NF-κB.

Inflammopharmacology.

2019 Aug 27(4):809-816.

(IF 3.238)

1497. Chen F, Zhou CC, Yang Y, Liu JW, Yan CH

.

GM1 Ameliorates Lead-Induced Cognitive Deficits and Brain Damage Through Activating the SIRT1/CREB/BDNF Pathway in the Developing Male Rat Hippocampus.

Biol Trace Elem Res.

2019 Aug 190(2):425-436.

(IF 2.639)

1498. Ren J, Li J, Hu J, Yu H, Yang Q, Mu J

.

Overexpression of CKIP-1 alleviates hypoxia-induced cardiomyocyte injury by up-regulating Nrf2 antioxidant signaling via Keap1 inhibition.

Biochimie.

2019 Aug 163:163-170.

(IF 3.413)

1499. Chen Z, Yang D, Jiang X, Tian L, Sun J, Tian D, Bai W

.

Final-2 targeted glycolysis mediated apoptosis and autophagy in human lung adenocarcinoma cells but failed to inhibit xenograft in nude mice.

Food Chem Toxicol.

2019 Aug 130:1-11.

(IF 4.679)

1500. Wang M, Wang Z, Zhu X, Guan S, Liu Z

.

NFKB1-miR-612-FAIM2 pathway regulates tumorigenesis in neurofibromatosis type 1.

IN VITRO CELL DEV-AN.

2019 Aug 55(7):491-500.

(IF 1.665)

1501. Tian X, Cong F, Guo H, Fan J, Chao G, Song T

.

Downregulation of Bach1 protects osteoblasts against hydrogen peroxide-induced oxidative damage in vitro by enhancing the activation of Nrf2/ARE signaling.

CHEM-BIOL INTERACT.

2019 Aug 25 309:108706.

(IF 3.723)

1502. Liu Q, Shuai M, Xia Y

.

Knockdown of EBV-encoded circRNA circRPMS1 suppresses nasopharyngeal carcinoma cell proliferation and metastasis through sponging multiple miRNAs.

Cancer Manag Res.

2019 Aug 27 11:8023-8031.

(IF 2.886)

1503. Liu H, Sun X, Gong X, Wang G

.

Human umbilical cord mesenchymal stem cells derived exosomes exert antiapoptosis effect via activating PI3K/Akt/mTOR pathway on H9C2 cells.

J Cell Biochem.

2019 Sep 120(9):14455-14464.

(IF 4.237)

1504. Zhang L, Zhang Y, Wang Z, Chen Y, Li R

.

Intermittent hyperbaric oxygen exposure mobilizing peroxiredoxin 6 to prevent oxygen toxicity.

J Physiol Sci.

2019 Sep 69(5):779-790.

(IF 2.955)

1505. Zeng YJ, Yang HR, Zong MH, Yang JG, Lou WY

.

Novel antibacterial polysaccharides produced by endophyte Fusarium solani DO7.

BIORESOURCE TECHNOL.

2019 Sep 288:121596.

(IF 7.539)

1506. Cui W, Liu CX, Zhang YC, Shen Q, Feng ZH, Wang J, Lu SF, Wu J, Li JX

.

A novel oleanolic acid derivative HA-19 ameliorates muscle atrophy via promoting protein synthesis and preventing protein degradation.

TOXICOL APPL PHARM .

2019 Sep 1 378:114625.

(IF 3.616)

1507. Shi R, Su WW, Zhu ZT, Guan MY, Cheng KL, Fan WY, Wei GY, Li PB, Yang ZY, Yao HL

.

Regulation effects of naringin on diesel particulate matter-induced abnormal airway surface liquid secretion.

Phytomedicine.

2019 Oct 63:153004.

(IF 4.268)

1508. Ji L, Bao L, Gu Z, Zhou Q, Liang Y, Zheng Y, Xu Y, Zhang X, Feng X

.

Comparison of immunomodulatory properties of exosomes derived from bone marrow mesenchymal stem cells and dental pulp stem cells.

Immunol Res.

2019 Oct 67(4-5):432-442.

(IF 2.507)

1509. Song G, Zhang Y, Yu S, Lv W, Guan Z, Sun M, Wang J

.

Chrysophanol attenuates airway inflammation and remodeling through nuclear factor-kappa B signaling pathway in asthma.

Phytother Res.

2019 Oct 33(10):2702-2713.

(IF 4.087)

1510. Wang X, Lu S, He C, Wang C, Wang L, Piao M, Chi G, Luo Y, Ge P

.

RSL3 induced autophagic death in glioma cells via causing glycolysis dysfunction.

BIOCHEM BIOPH RES CO.

2019 Oct 20 518(3):590-597.

(IF 2.985)

1511. Hao Y, Liu HM, Wei X, Gong X, Lu ZY, Huang ZH

.

Diallyl trisulfide attenuates hyperglycemia-induced endothelial apoptosis by inhibition of Drp1-mediated mitochondrial fission.

Acta Diabetol.

2019 Nov 56(11):1177-1189.

(IF 3.418)

1512. Yuan L, Zhao H, Liu L, Peng S, Li H, Wang H

.

Heterologous expression of the puuE from Oenococcus oeni SD-2a in Lactobacillus plantarum WCFS1 improves ethanol tolerance.

J BASIC MICROB.

2019 Nov 59(11):1134-1142.

(IF 1.909)

1513. Liu W, Ke M, Zhang Z, Lu T, Zhu Y, Li Y, Pan X, Qian H

.

Effects of imazethapyr spraying on plant growth and leaf surface microbial communities in Arabidopsis thaliana.

J ENVIRON SCI-CHINA.

2019 Nov 85:35-45.

(IF 3.556)

1514. Yu Z, Yu Z, Chen Z, Yang L, Ma M, Lu S, Wang C, Teng C, Nie Y

.

Zinc chelator TPEN induces pancreatic cancer cell death through causing oxidative stress and inhibiting cell autophagy.

J Cell Physiol.

2019 Nov 234(11):20648-20661.

(IF 5.546)

1515. Li J, Yuan YQ, Zhang L, Zhang H, Zhang SW, Zhang Y, Xuan XX, Wang MJ, Zhang JY

.

Exogenous hydrogen sulfide protects against high glucose-induced apoptosis and oxidative stress by inhibiting the STAT3/HIF-1α pathway in H9c2 cardiomyocytes.

Exp Ther Med.

2019 Nov 18(5):3948-3958.

(IF 1.785)

1516. Li Y, Li R, Ouyang N, Dai K, Yuan P, Zheng L, Wang W

.

Investigating the impact of local inflammation on granulosa cells and follicular development in women with ovarian endometriosis.

Fertil Steril.

2019 Nov 112(5):882-891.e1.

(IF 6.312)

1517. Guan L, Che Z, Meng X, Yu Y, Li M, Yu Z, Shi H, Yang D, Yu M

.

MCU Up-regulation contributes to myocardial ischemia-reperfusion Injury through calpain/OPA-1-mediated mitochondrial fusion/mitophagy Inhibition.

J Cell Mol Med.

2019 Nov 23(11):7830-7843.

(IF 4.486)

1518. Cao R, Fang D, Wang J, Yu Y, Ye H, Kang P, Li Z, Wang H, Gao Q

.

ALDH2 Overexpression Alleviates High Glucose-Induced Cardiotoxicity by Inhibiting NLRP3 Inflammasome Activation.

J Diabetes Res.

2019 Nov 21 2019:4857921.

(IF 2.965)

1519. Wenbo Jiang, Bai Li, Yingying Chen, Shuying Gao.

.

The toxic influence of dibromoacetic acid on the hippocampus and pre-frontal cortex of rat: involvement of neuroinflammation response and oxidative stress.

Metabolic Brain Disease.

December 2017, Volume 32, Issue 6, pp 2009–2019.

(IF 2.411)

1520. Li H, Di G, Zhang Y, Xue R, Zhang J, Liang J

.

MicroRNA-155 and microRNA-181a, via HO-1, participate in regulating the immunotoxicity of cadmium in the kidneys of exposed Cyprinus carpio.

FISH SHELLFISH IMMUN.

2019 Dec 95:473-480.

(IF 3.298)

1521. Zhang X, Hu F, Liu L, Xu B

.

Effect of silencing of mediator of DNA damage checkpoint protein 1 on the growth of oral squamous cell carcinoma in vitro and in vivo.

Eur J Oral Sci.

2019 Dec 127(6):494-499.

(IF 2.22)

1522. Liu ZN, Jia WQ, Jiang T, Dai JW, Shuai C, Lv XW

.

Regulation of CD39 expression in ATP-P2Y2R-mediated alcoholic liver steatosis and inflammation.

Int Immunopharmacol.

2019 Dec 77:105915.

(IF 3.943)

1523. Deng H, Ma J, Liu Y, He P, Dong W

.

Combining α-Hederin with cisplatin increases the apoptosis of gastric cancer in vivo and in vitro via mitochondrial related apoptosis pathway.

Biomed Pharmacother.

2019 Dec 120:109477.

(IF 4.545)

1524. Lei M, Ma G, Sha S, Wang X, Feng H, Zhu Y, Du X

.

Dual-functionalized liposome by co-delivery of paclitaxel with sorafenib for synergistic antitumor efficacy and reversion of multidrug resistance.

Drug Deliv.

2019 Dec 26(1):262-272.

(IF 4.902)

1525. Minjuan Wang, Chengliang Li, Wei Shi

.

Stomatin-like protein-2 Confers Neuroprotection Effect in Oxygen-Glucose Deprivation/Reoxygenation-Injured Neurons by Regulating AMPK/Nrf2 Signalling

J Drug Target.

2019 Dec 16;1-9. doi: 10.1080/1061186X.2019.1700262.

(IF 3.38)

1526. Qingqing Li, Xueyan Liang, Yufang Yang, Xian Zeng, Xiaobin Zhong, Chun Huang

.

Panax Notoginseng Saponins Ameliorate Cisplatin-Induced Mitochondrial Injury via the HIF-1α/mitochondria/ROS Pathway

FEBS Open Bio.

2020 Jan;10(1):118-126. doi: 10.1002/2211-5463.12760.

(IF 2.231)

1527. Man Luo, Ji-Cheng Huang, Zhan-Qing Yang, Yu-Si Wang, Bin Guo, Zhan-Peng Yue

.

Hydroxysafflor Yellow A Exerts Beneficial Effects by Restoring Hormone Secretion and Alleviating Oxidative Stress in Polycystic Ovary Syndrome Mice

Exp Physiol.

2020 Feb;105(2):282-292. doi: 10.1113/EP088147.

(IF 2.431)

1528. Geng H, Hao L, Cheng Y, Wang C, Huang S, Wei W, Yang R, Li H, Liu S, Yu H, Lu H

.

Interaction between CA repeat microsatellites and HIF1α regulated the transcriptional activity of porcine IGF1 promoter.

J Appl Genet.

2020 Feb 61(1):105-112.

(IF 2.027)

1529. Luo M, Yang ZQ, Huang JC, Wang YS, Guo B, Yue ZP

.

Genistein protects ovarian granulosa cells from oxidative stress via cAMP-PKA signaling.

Cell Biol Int.

2020 Feb 44(2):433-445.

(IF 2.571)

1530. Zhang H, Gu H, Jia Q, Zhao Y, Li H, Shen S, Liu X, Wang G, Shi Q

.

Syringin protects against colitis by ameliorating inflammation.

Arch Biochem Biophys.

2020 Feb 15 680:108242.

(IF 3.391)

1531. Yi L, Juan W, Gang C, Leiming Z, Jianning Z

.

Seawater Immersion Aggravates Early Mitochondrial Dysfunction and Increases Neuronal Apoptosis After Traumatic Brain Injury.

Cell Mol Neurobiol.

2020 Apr 40(3):447-457.

(IF 3.606)

1532. Yanlin Chen, Liping Yang, Yilu Qin, Shuiqing Liu, Yina Qiao, Xueying Wan, Huan Zeng, Xiaoli Tang, Manran Liu, Yixuan Hou

.

Effects of differential distributed-JUP on the malignancy of gastric cancer

J Adv Res.

2020 Jul 6;28:195-208. doi: 10.1016/j.jare.2020.06.026.

(IF 6.992)

1533. Qinghai Meng, Yu Li, Tingting Ji, Ying Chao, Jun Li, Yu Fu, Suyun Wang, Qi Chen, Wen Chen, Fuhua Huang, Youran Wang, Qichun Zhang, Xiaoliang Wang, Huimin Bian

.

Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor α-mediated autophagy

J Adv Res.

2020 Aug 24;28:149-164. doi: 10.1016/j.jare.2020.08.010.

(IF 6.992)

1534. Ning Zhang, Hongdan Xu, Yueying Wang, Yuan Yao, Guoliang Liu, Xia Lei, Huifeng Sun, Xiuhong Wu, Jianmin Li

.

Protective mechanism of kaempferol against Aβ25-35-mediated apoptosis of pheochromocytoma (PC-12) cells through the ER/ERK/MAPK signalling pathway

Arch Med Sci.

2020 Aug 25;17(2):406-416. doi: 10.5114/aoms.2020.98199.

(IF 2.807)

1535. Xi He, Wenxiu Xie, Huiling Li, Yiqiang Cui, Ya Wang, Xuejiang Guo, Jiahao Sha

.

The testis-specifically expressed gene Trim69 is not essential for fertility in mice

J Biomed Res.

2020 Aug 21;35(1):47-60. doi: 10.7555/JBR.34.20200069.

1536. Jiangyu Cai, Qianqian Zhang, Jiebo Chen, Jia Jiang, Xiumei Mo, Chuanglong He, Jinzhong Zhao

.

Electrodeposition of calcium phosphate onto polyethylene terephthalate artificial ligament enhances graft-bone integration after anterior cruciate ligament reconstruction

Bioact Mater.

2020 Sep 29;6(3):783-793. doi: 10.1016/j.bioactmat.2020.08.037.

1537. Jian Chen, Biao Luo, Bi-Rou Zhong, Kun-Yi Li, Qi-Xin Wen, Li Song, Xiao-Jiao Xiang, Gui-Feng Zhou, Li-Tian Hu, Xiao-Juan Deng, Yuan-Lin Ma, Guo-Jun Chen

.

Sulfuretin exerts diversified functions in the processing of amyloid precursor protein

Genes Dis.

2020 Nov 21;8(6):867-881. doi: 10.1016/j.gendis.2020.11.008.

1538. Jie Liu, Yuyu Xie, Zhangbo Cui, Tian Xia, Lu Wan, Haifeng Zhou, Peng Zhang, Yijie Zhang, Fei Guan, Wenqi Liu, Chunwei Shi

.

Bnip3 interacts with vimentin, an intermediate filament protein, and regulates autophagy of hepatic stellate cells

Aging (Albany NY).

2020 Dec 3;13(1):957-972. doi: 10.18632/aging.202211.

1539. Xinyuan Jiang, Qingdong Wu, Cuicui Zhang, Maobo Wang

.

Homoharringtonine Inhibits Alzheimer's Disease Progression by Reducing Neuroinflammation via STAT3 Signaling in APP/PS1 Mice

Neurodegener Dis.

2021;21(3-4):93-102. doi: 10.1159/000519974.

(IF 2.418)

1540. Zhongyuan Piao, Lin Song, Lifen Yao, Limei Zhang, Yichan Lu

.

Schisandrin Restores the Amyloid β-Induced Impairments on Mitochondrial Function, Energy Metabolism, Biogenesis, and Dynamics in Rat Primary Hippocampal Neurons

Pharmacology.

2021;106(5-6):254-264. doi: 10.1159/000507818.

(IF 1.625)

1541. Xiao-Wen Lian, Bin Luo

.

Knockdown of NEAT1 induced microglial M2 polarization via miR‑374a‑5p/NFAT5 axis to inhibit inflammatory response caused by OGD/R

Acta Neurobiol Exp (Wars).

2021;81(4):362-374.

1542. Huanzhi Zhao, Shunhai Zhu, Qiping Zhao, Bing Huang, Guiling Liu, Zhihang Li, Lu Wang, Hui Dong, Hongyu Han

.

Molecular characterization and protective efficacy of a new conserved hypothetical protein of Eimeria tenella

Parasite.

2021;28:40. doi: 10.1051/parasite/2021037.

(IF 2.05)

1543. Hua Fang, Miao Yang, Qin Pan, Hon-Ling Jin, Hua-Feng Li, Ru-Rong Wang, Quan-Yun Wang, Jian-Ping Zhang

.

MicroRNA-22-3p alleviates spinal cord ischemia/reperfusion injury by modulating M2 macrophage polarization via IRF5

J Neurochem.

2021 Jan;156(1):106-120. doi: 10.1111/jnc.15042.

(IF 4.066)

1544. Haibo Xu, Qian Qi, Xixin Yan

.

Myricetin ameliorates sepsis-associated acute lung injury in a murine sepsis model

Naunyn Schmiedebergs Arch Pharmacol.

2021 Jan;394(1):165-175. doi: 10.1007/s00210-020-01880-8.

1545. Qun Zhao, Yun Bi, Jian Guo, Yingxiang Liu, Jing Zhong, Yongqiang Liu, Longrui Pan, Yang Guo, Yan Tan, Xianjun Yu

.

Effect of pristimerin on apoptosis through activation of ROS/ endoplasmic reticulum (ER) stress-mediated noxa in colorectal cancer

Phytomedicine.

2021 Jan;80:153399. doi: 10.1016/j.phymed.2020.153399.

(IF 4.268)

1546. Miao Zhang, Yuan Hu, Jiahui Zhang, Junjian Zhang

.

FTY720 Prevents Spatial Memory Impairment in a Rat Model of Chronic Cerebral Hypoperfusion via a SIRT3-Independent Pathway

Front Aging Neurosci.

2021 Jan 14;12:593364. doi: 10.3389/fnagi.2020.593364.

(IF 4.362)

1547. Sihong Li, Ruimeng Liu, Gaoqiang Wei, Guifang Guo, Hongxiao Yu, Yixin Zhang, Muhammad Ishfaq, Saqib Ali Fazilani, Xiuying Zhang

.

Curcumin protects against Aflatoxin B1-induced liver injury in broilers via the modulation of long non-coding RNA expression

Ecotoxicol Environ Saf.

2021 Jan 15;208:111725. doi: 10.1016/j.ecoenv.2020.111725.

1548. Mingda Li, Jie Jia, Shanshan Li, Baocheng Cui, Jiao Huang, Zhaoming Guo, Kun Ma, Li Wang, Changhao Cui

.

Exosomes derived from tendon stem cells promote cell proliferation and migration through the TGF β signal pathway

Biochem Biophys Res Commun.

2021 Jan 15;536:88-94. doi: 10.1016/j.bbrc.2020.12.057.

1549. Qing Zhang, Ting Chen, Yun Zhang, Lingxia Lyu, Bohuan Zhang, Chengchen Huang, Xuhao Zhou, Yutao Wu, Zhoubin Li

.

MiR-30c-5p regulates adventitial progenitor cells differentiation to vascular smooth muscle cells through targeting OPG

Stem Cell Res Ther.

2021 Jan 19;12(1):67. doi: 10.1186/s13287-020-02127-2.

(IF 5.116)

1550. Linjie Ju, Peipei Hu, Ping Chen, Jiejie Wu, Zhuoqun Li, Zhixia Qiu, Jun Cheng, Fang Huang

.

Corydalis Saxicola Bunting Total Alkaloids Attenuate Walker 256-Induced Bone Pain and Osteoclastogenesis by Suppressing RANKL-Induced NF-κB and c-Fos/NFATc1 Pathways in Rats

Front Pharmacol.

2021 Jan 26;11:609119. doi: 10.3389/fphar.2020.609119.

(IF 4.225)

1551. Xue Wang, Hong Zhu, Lei Lei, Yang Zhang, Chao Tang, Jia-Xing Wu, Jie-Ru Zhou, Xi-Rong Xiao

.

Integrated Analysis of Key Genes and Pathways Involved in Fetal Growth Restriction and Their Associations With the Dysregulation of the Maternal Immune System

Front Genet.

2021 Jan 8;11:581789. doi: 10.3389/fgene.2020.581789.

(IF 3.258)

1552. Meng Xia, Xuena Li, Yao Diao, Bulin Du, Yaming Li

.

Targeted inhibition of glutamine metabolism enhances the antitumor effect of selumetinib in KRAS-mutant NSCLC

Transl Oncol.

2021 Jan;14(1):100920. doi: 10.1016/j.tranon.2020.100920.

(IF 3.558)

1553. Hao Jiang, Yanping Zou, Jihong Zhao, Xuecong Li, Shaodong Yang, Xiaoshun Zhou, Dongsheng Mou, Wenqun Zhong, Yu Cai

.

Pyruvate Kinase M2 Mediates Glycolysis in the Lymphatic Endothelial Cells and Promotes the Progression of Lymphatic Malformations

Am J Pathol.

2021 Jan;191(1):204-215. doi: 10.1016/j.ajpath.2020.10.003.

(IF 3.491)

1554. Jia-Yan Chen, You-Xiang Wang, Ke-Feng Ren, Yun-Bing Wang, Guo-Sheng Fu, Jian Ji

.

The influence of substrate stiffness on osteogenesis of vascular smooth muscle cells

Colloids Surf B Biointerfaces.

2021 Jan;197:111388. doi: 10.1016/j.colsurfb.2020.111388.

1555. Sa Ye, Hong-Bin Zhou, Ying Chen, Kai-Qiang Li, Shan-Shan Jiang, Ke Hao

.

Crizotinib changes the metabolic pattern and inhibits ATP production in A549 non-small cell lung cancer cells

Oncol Lett.

2021 Jan;21(1):61. doi: 10.3892/ol.2020.12323.

(IF 2.311)

1556. Huasong Luo, Rui Zhang

.

Icariin enhances cell survival in lipopolysaccharide-induced synoviocytes by suppressing ferroptosis via the Xc-/GPX4 axis

Exp Ther Med.

2021 Jan;21(1):72. doi: 10.3892/etm.2020.9504.

(IF 1.785)

1557. Hongwei Lu, Changchang Fu, Suyan Kong, Xudong Wang, Lin Sun, Zeng Lin, Peng Luo, Haidong Jin

.

Maltol prevents the progression of osteoarthritis by targeting PI3K/Akt/NF-κB pathway: In vitro and in vivo studies

J Cell Mol Med.

2021 Jan;25(1):499-509. doi: 10.1111/jcmm.16104.

(IF 4.486)

1558. Fengqi Jiang, Shuo Ren, Yaodong Chen, Ange Zhang, Yuekun Zhu, Zhenan Zhang, Zizhuo Li, Daxun Piao

.

Fangchinoline exerts antitumour activity by suppressing the EGFR‑PI3K/AKT signalling pathway in colon adenocarcinoma

Oncol Rep.

2021 Jan;45(1):139-150. doi: 10.3892/or.2020.7857.

(IF 3.417)

1559. Li Zhang, Shixia Zhou, Tiejun Zhou, Kaifeng Yuan, Xiaoming Li, Junling Tang

.

S100A8 promotes chemoresistance via augmenting autophagy in B‑cell lymphoma cells

Oncol Rep.

2021 Jan;45(1):151-158. doi: 10.3892/or.2020.7841.

(IF 3.417)

1560. Y Miao, M Ishfaq, Y Liu, Z Wu, J Wang, R Li, F Qian, L Ding, J Li

.

Baicalin attenuates endometritis in a rabbit model induced by infection with Escherichia coli and Staphylococcus aureus via NF-κB and JNK signaling pathways

Domest Anim Endocrinol.

2021 Jan;74:106508. doi: 10.1016/j.domaniend.2020.106508.

1561. Yingying Wang, Yingshuang Song, Qi Zhong, Yaqin Wu, Jiabao Zhuang, Fang Qu, Chun Xu

.

Suppressing ROS generation by apocynin inhibited cyclic stretch-induced inflammatory reaction in HPDLCs via a caspase-1 dependent pathway

Int Immunopharmacol.

2021 Jan;90:107129. doi: 10.1016/j.intimp.2020.107129.

(IF 3.943)

1562. Qingfei Xiao, Yan Cui, Yongli Zhao, Li Liu, Hongyue Wang, Liming Yang

.

Orientin relieves lipopolysaccharide-induced acute lung injury in mice: The involvement of its anti-inflammatory and anti-oxidant properties

Int Immunopharmacol.

2021 Jan;90:107189. doi: 10.1016/j.intimp.2020.107189.

(IF 3.943)

1563. Dongliang Zhang, Lan Jiang, Mengling Wang, Meiping Jin, Xuemei Zhang, Difa Liu, Zhangwei Wang, Licai Yang, Xudong Xu

.

Berberine inhibits intestinal epithelial barrier dysfunction in colon caused by peritoneal dialysis fluid by improving cell migration

J Ethnopharmacol.

2021 Jan 10;264:113206. doi: 10.1016/j.jep.2020.113206.

(IF 3.69)

1564. Ning Ma, Xingjie Li, Hongyu Jiang, Yulong Dai, Guofeng Xu, Zongde Zhang

.

Influenza Virus Neuraminidase Engages CD83 and Promotes Pulmonary Injury

J Virol.

2021 Jan 13;95(3):e01753-20. doi: 10.1128/JVI.01753-20.

(IF 4.501)

1565. Wenchao Zhang, Jianwei Liu, Yang Fu, Huifang Ji, Zheyan Fang, Wanming Zhou, Huimin Fan, Yingxuan Zhang, Yan Liao, Ting Yang, Xiaolin Wang, Wanwan Yuan, Xiaoshu Chen, Yi-Fei Dong

.

Sacubitril/Valsartan Reduces Fibrosis and Alleviates High-Salt Diet-Induced HFpEF in Rats

Front Pharmacol.

2021 Jan 14;11:600953. doi: 10.3389/fphar.2020.600953.

(IF 4.225)

1566. Huan Liu, Huidan Deng, Hengmin Cui, Zhijie Jian, Hongrui Guo, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao

.

Copper induces hepatocyte autophagy via the mammalian targets of the rapamycin signaling pathway in mice

Ecotoxicol Environ Saf.

2021 Jan 15;208:111656. doi: 10.1016/j.ecoenv.2020.111656.

1567. Ying Luo, Li-Mei Liu, Li Xie, Hong-Lei Zhao, Yong-Kang Lu, Bao-Quan Wu, Zhi-Ye Wu, Zhi-Ling Zhang, Yun-Ling Hao, Wu-Hua Ou, Rui-Shuang Liu, Wen-Min Xu, Xie-Hui Chen

.

Activation of the CaR-CSE/H2S pathway confers cardioprotection against ischemia-reperfusion injury

Exp Cell Res.

2021 Jan 15;398(2):112389. doi: 10.1016/j.yexcr.2020.112389.

(IF 3.383)

1568. Lishen Ren, Dongrui Guo, Xiaohui Wan, Rongfeng Qu

.

EYA2 upregulates miR-93 to promote tumorigenesis of breast cancer by targeting and inhibiting the STING signaling pathway

Carcinogenesis.

2021 Jan 15;bgab001. doi: 10.1093/carcin/bgab001.

(IF 4.603)

1569. Fangyuan Jia, Qi Wu, Zhiwei Wang, Min Zhang, Shun Yuan, Yanjia Che, Bowen Li, Zhipeng Hu, Xiaoping Hu

.

BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis

Oxid Med Cell Longev.

2021 Jan 16;2021:5986260. doi: 10.1155/2021/5986260.

(IF 5.076)

1570. Guoyuan Pan, Huimei Zhang, Anqi Zhu, Yao Lin, Lili Zhang, Bingyun Ye, Jingyan Cheng, Weimin Shen, Lingqin Jin, Chan Liu, Qingfeng Xie, Xiang Chen

.

Treadmill exercise attenuates cerebral ischaemic injury in rats by protecting mitochondrial function via enhancement of caveolin-1

Life Sci.

2021 Jan 1;264:118634. doi: 10.1016/j.lfs.2020.118634.

(IF 3.647)

1571. Guangdong Zhang, Fangli Zhong, Lei Chen, Peipei Qin, Junmei Li, Feijie Zhi, Lulu Tian, Dong Zhou, Pengfei Lin, Huatao Chen, Keqiong Tang, Wei Liu, Yaping Jin, Aihua Wang

.

Integrated Proteomic and Transcriptomic Analyses Reveal the Roles of Brucella Homolog of BAX Inhibitor 1 in Cell Division and Membrane Homeostasis of Brucella suis S2

Front Microbiol.

2021 Jan 28;12:632095. doi: 10.3389/fmicb.2021.632095.

(IF 4.235)

1572. Dan Song, Yaohua Chen, Cheng Chen, Lili Chen, Oumei Cheng

.

GABAB receptor antagonist promotes hippocampal neurogenesis and facilitates cognitive function recovery following acute cerebral ischemia in mice

Stem Cell Res Ther.

2021 Jan 7;12(1):22. doi: 10.1186/s13287-020-02059-x.

(IF 5.116)

1573. Yahong Liu, Lei Qi, Keping Zhang, Fuxin Wang

.

MicroRNA-10a suppresses cell metastasis by targeting BDNF and predicted patients survival in renal cell carcinoma

J BUON.

2021 Jan-Feb;26(1):250-258.

(IF 1.695)

1574. Gangyin Xie, Linxiao Sun, Yonglin Li, Bicheng Chen, Cheng Wang

.

Periplocin inhibits the growth of pancreatic cancer by inducing apoptosis via AMPK-mTOR signaling

Cancer Med.

2021 Jan;10(1):325-336. doi: 10.1002/cam4.3611.

1575. Fang Han, Hui Guo, Leyi Wang, Yuting Zhang, Lin Sun, Chenyang Dai, Xinyi Wu

.

The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis

Exp Eye Res.

2021 Jan;202:108366. doi: 10.1016/j.exer.2020.108366.

(IF 3.011)

1576. Hangwei Fu, Yida Zhang, Yin Chen, Junying Chen, Ping Chen

.

CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression

Mol Med Rep.

2021 Jan;23(1):46. doi: 10.3892/mmr.2020.11684.

(IF 2.1)

1577. Jing Zhang, Na Jiang, Jian Ping, Lieming Xu

.

TGF‑β1‑induced autophagy activates hepatic stellate cells via the ERK and JNK signaling pathways

Int J Mol Med.

2021 Jan;47(1):256-266. doi: 10.3892/ijmm.2020.4778.

(IF 3.098)

1578. Tong Zhou, Bolan Zhou, Yasong Zhao, Qing Li, Guili Song, Zuoyan Zhu, Yong Long, Zongbin Cui

.

Development of a Mucus Gland Bioreactor in Loach Paramisgurnus dabryanus

Int J Mol Sci.

2021 Jan 12;22(2):687. doi: 10.3390/ijms22020687.

(IF 4.556)

1579. Ping Lin, Hui-Ru Bai, Ling He, Qiu-Xiang Huang, Qin-Han Zeng, Yuan-Zhi Pan, Bei-Bei Jiang, Fan Zhang, Lei Zhang, Qing-Lin Liu

.

Proteome-wide and lysine crotonylation profiling reveals the importance of crotonylation in chrysanthemum (Dendranthema grandiforum) under low-temperature

BMC Genomics.

2021 Jan 14;22(1):51. doi: 10.1186/s12864-020-07365-5.

(IF 3.594)

1580. Panpan Meng, Yi-Fan Zhang, Wangli Zhang, Xin Chen, Tong Xu, Sheng Hu, Xinjun Liang, Mingqian Feng, Xiaoqing Yang, Mitchell Ho

.

Identification of the atypical cadherin FAT1 as a novel glypican-3 interacting protein in liver cancer cells

Sci Rep.

2021 Jan 8;11(1):40. doi: 10.1038/s41598-020-79524-3.

1581. Xiao Lin, Yuxuan Mao, Peng Li, Yanjie Bai, Tao Chen, Kang Wu, Dandan Chen, Huilin Yang, Lei Yang

.

Ultra-Conformable Ionic Skin with Multi-Modal Sensing, Broad-Spectrum Antimicrobial and Regenerative Capabilities for Smart and Expedited Wound Care

Adv Sci (Weinh).

2021 Feb 15;8(9):2004627. doi: 10.1002/advs.202004627.

1582. Run-Ze Yang, Huo-Liang Zheng, Wen-Ning Xu, Xin-Feng Zheng, Bo Li, Lei-Sheng Jiang, Sheng-Dan Jiang

.

Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis

Aging (Albany NY).

2021 Feb 1;13(3):4647-4662. doi: 10.18632/aging.202506.

1583. Yuqi Lai, Qinxiang Tan, Shu Xv, Sha Huang, Yuhua Wang, Yunjia Li, Ting Zeng, Chan Mo, Yuyao Chen, Shaohui Huang, Chuying Zhou, Lei Gao, Zhiping Lv

.

Ginsenoside Rb1 Alleviates Alcohol-Induced Liver Injury by Inhibiting Steatosis, Oxidative Stress, and Inflammation

Front Pharmacol.

2021 Feb 26;12:616409. doi: 10.3389/fphar.2021.616409.

(IF 4.225)

1584. Yujing Cao, Qiuxia Lv, Yang Li

.

Astragaloside IV Improves Tibial Defect in Rats and Promotes Proliferation and Osteogenic Differentiation of hBMSCs through MiR-124-3p.1/STAT3 Axis

J Nat Prod.

2021 Feb 26;84(2):287-297. doi: 10.1021/acs.jnatprod.0c00975.

(IF 3.779)

1585. Boying Zhao, Renfu Lu, Jianjun Chen, Ming Xie, Xingji Zhao, Lingwen Kong

.

S100A9 blockade prevents lipopolysaccharide-induced lung injury via suppressing the NLRP3 pathway

Respir Res.

2021 Feb 6;22(1):45. doi: 10.1186/s12931-021-01641-y.

1586. Yang Liu, Xue-Bin Hu, Li-Zhi Zhang, Zi Wang, Rong Fu

.

Knockdown of Arginyl-tRNA Synthetase Attenuates Ischemia-Induced Cerebral Cortex Injury in Rats After Middle Cerebral Artery Occlusion

Transl Stroke Res.

2021 Feb;12(1):147-163. doi: 10.1007/s12975-020-00809-w.

(IF 5.78)

1587. Yue Wang, Xiaozhou Wang, Lumei Wang, Guodong Cheng, Meihua Zhang, Yuxiao Xing, Xiaona Zhao, Yongxia Liu, Jianzhu Liu

.

Mitophagy Induced by Mitochondrial Function Damage in Chicken Kidney Exposed to Cr(VI)

Biol Trace Elem Res.

2021 Feb;199(2):703-711. doi: 10.1007/s12011-020-02176-x.

(IF 2.639)

1588. Meng Wang, Yong Nie, Xiao-Lei Wu

.

Membrane vesicles from a Dietzia bacterium containing multiple cargoes and their roles in iron delivery

Environ Microbiol.

2021 Feb;23(2):1009-1019. doi: 10.1111/1462-2920.15278.

(IF 4.933)

1589. Jinming Zhu, Chunling Ma, Xiaomei Luan, Juan Li, Fengyun Peng, Lei Huang

.

Inflammasome components and ADAMTS4 in premature rupture of membranes

Mol Med Rep.

2021 Feb;23(2):101. doi: 10.3892/mmr.2020.11740.

(IF 2.1)

1590. Xiu-Dan Li, Shan-Shan He, Ting-Ting Wan, Yan-Bo Li

.

Liraglutide protects palmitate-induced INS-1 cell injury by enhancing autophagy mediated via FoxO1

Mol Med Rep.

2021 Feb;23(2):147. doi: 10.3892/mmr.2020.11786.

(IF 2.1)

1591. Jia-Huan Sun, Hong-Xia Yang, Ting-Ting Yao, Yuan Li, Lin Ruan, Geng-Rui Xu, Chuang Zhang, Guo-Xin Guo, Ai-Ying Li

.

Gentianella acuta prevents acute myocardial infarction induced by isoproterenol in rats via inhibition of galectin-3/TLR4/MyD88/NF-кB inflammatory signalling

Inflammopharmacology.

2021 Feb;29(1):205-219. doi: 10.1007/s10787-020-00708-4.

(IF 3.238)

1592. Bin Qi, Xiaowen Zhang, Hang Yu, Yandong Bao, Nan Wu, Dalin Jia

.

Brazilin prevents against myocardial ischemia-reperfusion injury through the modulation of Nrf2 via the PKC signaling pathway

Ann Transl Med.

2021 Feb;9(4):312. doi: 10.21037/atm-20-4414.

(IF 3.297)

1593. Ning Zhang, Lingran Zhang, Linjie Li, Junyou Geng, Lei Zhao, Yan Ren, Zhongdong Dong, Feng Chen

.

Global Profiling of 2-hydroxyisobutyrylome in Common Wheat

Genomics Proteomics Bioinformatics.

2021 Feb 10;S1672-0229(21)00007-3. doi: 10.1016/j.gpb.2020.06.008.

1594. Chengchuang Zhan, Nan Bai, Min Zheng, Yanyan Wang, Yuanqi Wang, Li Zhang, Jianqiang Li, Guangnan Li, Hongyan Zhao, Guangzhong Liu, Qi Lou, Wen Yang, Tiankai Li, Luyifei Li, Weimin Li

.

Tranilast prevents doxorubicin-induced myocardial hypertrophy and angiotensin II synthesis in rats

Life Sci.

2021 Feb 15;267:118984. doi: 10.1016/j.lfs.2020.118984.

(IF 3.647)

1595. Hao Wu, Yijun Chu, Shanshan Sun, Guozheng Li, Shouping Xu, Xianyu Zhang, Yongdong Jiang, Song Gao, Qin Wang, Jian Zhang, Da Pang

.

Hypoxia-Mediated Complement 1q Binding Protein Regulates Metastasis and Chemoresistance in Triple-Negative Breast Cancer and Modulates the PKC-NF-κB-VCAM-1 Signaling Pathway

Front Cell Dev Biol.

2021 Feb 23;9:607142. doi: 10.3389/fcell.2021.607142.

(IF 5.201)

1596. Xing Du, Qiqi Li, Liu Yang, Qiang Zeng, Siqi Wang, Qifa Li

.

Transcriptomic Data Analyses Reveal That Sow Fertility-Related lincRNA NORFA Is Essential for the Normal States and Functions of Granulosa Cells

Front Cell Dev Biol.

2021 Feb 23;9:610553. doi: 10.3389/fcell.2021.610553.

(IF 5.201)

1597. Mianjie Lin, Ya-Nan Wang, Yixin Ye, Zhelei Xiong, Fengbiao Guo, Haibin Chen

.

DNAJC12 as a Mediator Between ESR1 and ERBB4 in Breast Carcinoma Cells

Front Oncol.

2021 Feb 24;11:582277. doi: 10.3389/fonc.2021.582277.

(IF 4.848)

1598. Yue Wu, Yang Xun, Jiaqiao Zhang, Henglong Hu, Baolong Qin, Tao Wang, Shaogang Wang, Cong Li, Yuchao Lu

.

Resveratrol Attenuates Oxalate-Induced Renal Oxidative Injury and Calcium Oxalate Crystal Deposition by Regulating TFEB-Induced Autophagy Pathway

Front Cell Dev Biol.

2021 Feb 25;9:638759. doi: 10.3389/fcell.2021.638759.

(IF 5.201)

1599. Hua-Su Zhu, Dong Li, Cong Li, Jin-Xian Huang, Shan-Shan Chen, Lan-Bo Li, Qing Shi, Xiu-Li Ju

.

Prior transfusion of umbilical cord mesenchymal stem cells can effectively alleviate symptoms of motion sickness in mice through interleukin 10 secretion

World J Stem Cells.

2021 Feb 26;13(2):177-192. doi: 10.4252/wjSC.v13.i2.177.

(IF 3.231)

1600. Qiqi Cao, Chun Zhao, Congjing Wang, Lingbo Cai, Meng Xia, Xiaolan Zhang, Jian Han, Yangyang Xu, Junqiang Zhang, Xiufeng Ling, Xiang Ma, Ran Huo

.

The Recurrent Mutation in PATL2 Inhibits Its Degradation Thus Causing Female Infertility Characterized by Oocyte Maturation Defect Through Regulation of the Mos-MAPK Pathway

Front Cell Dev Biol.

2021 Feb 4;9:628649. doi: 10.3389/fcell.2021.628649.

(IF 5.201)

1601. Tianle Gu, Dandan Yu, Ling Xu, Yu-Lin Yao, Xiao Zheng, Yong-Gang Yao

.

Tupaia guanylate-binding protein 1 interacts with vesicular stomatitis virus phosphoprotein and represses primary transcription of the viral genome

Cytokine.

2021 Feb;138:155388. doi: 10.1016/j.cyto.2020.155388.

(IF 2.952)

1602. Jian Hu, Pei-Le Liu, Yan Hua, Bei-Yao Gao, Yu-Yuan Wang, Yu-Long Bai, Chan Chen

.

Constraint-induced movement therapy enhances AMPA receptor-dependent synaptic plasticity in the ipsilateral hemisphere following ischemic stroke

Neural Regen Res.

2021 Feb;16(2):319-324. doi: 10.4103/1673-5374.290900.

(IF 3.171)

1603. Xiaotao Xu, Yang Su, Kaixuan Wu, Fan Pan, Aizhong Wang

.

DOCK2 contributes to endotoxemia-induced acute lung injury in mice by activating proinflammatory macrophages

Biochem Pharmacol.

2021 Feb;184:114399. doi: 10.1016/j.bcp.2020.114399.

(IF 4.96)

1604. Yuhao Wu, Junke Wang, Tianxin Zhao, Yuexin Wei, Lindong Han, Lianju Shen, Chunlan Long, Shengde Wu, Guanghui Wei

.

LncRNAs activate longevity regulation pathway due to aging of Leydig cells caused by DEHP exposure: A transcriptome-based study

Ecotoxicol Environ Saf.

2021 Feb;209:111798. doi: 10.1016/j.ecoenv.2020.111798.

1605. Yunfei Wang, Jialong Qi, Han Cao, Cunbao Liu

.

Immune Responses to Varicella-Zoster Virus Glycoprotein E Formulated with Poly(Lactic-co-Glycolic Acid) Nanoparticles and Nucleic Acid Adjuvants in Mice

Virol Sin.

2021 Feb;36(1):122-132. doi: 10.1007/s12250-020-00261-y.

(IF 3.242)

1606. Qingqing Yi, Weiwei Cai, Qing Chang, Dongyu Liang, Rong Yang, Guowei Jiang, Liying Qiu

.

Effect of extract from Yiyuan Yiliu Tang on human lung adenocarcinoma and human hepatoma cell lines

J Tradit Chin Med.

2021 Feb;41(1):36-43. doi: 10.19852/j.cnki.jtcm.2021.01.005.

(IF 0.676)

1607. Yuyi Chen, Qiudong Yang, Chunhua Lv, Yue Chen, Wenhua Zhao, Wenlei Li, Hongyu Chen, Hua Wang, Wen Sun, Hua Yuan

.

NLRP3 regulates alveolar bone loss in ligature-induced periodontitis by promoting osteoclastic differentiation

Cell Prolif.

2021 Feb;54(2):e12973. doi: 10.1111/cpr.12973.

1608. Yin-Ling Zhang, Geng Xue, Hui Miao, Chuan-Chuan Zhou, Shu-Han Sun, Yi Zhang

.

Folic acid supplementation acts as a chemopreventive factor in tumorigenesis of hepatocellular carcinoma by inducing H3K9Me2-dependent transcriptional repression of LCN2

Oncotarget.

2021 Feb 16;12(4):366-378. doi: 10.18632/oncotarget.27136.

1609. Jiguang Li, Yanlan Wang, Liqun Wang, Jianyu Zhu, Jing Deng, Rui Tang, Guanghui Chen

.

Integration of transcriptomic and proteomic analyses for finger millet [Eleusine coracana (L.) Gaertn.] in response to drought stress

PLoS One.

2021 Feb 17;16(2):e0247181. doi: 10.1371/journal.pone.0247181.

(IF 2.74)

1610. Shiping Huang, Yueming Sun

.

Long noncoding RNA MNX1-AS1 functions as a competing endogenous RNA to regulate epithelial-mesenchymal transition by sponging MiR-744-5p in colorectal cancer

Biosci Biotechnol Biochem.

2021 Feb 24;85(3):568-578. doi: 10.1093/bbb/zbaa096.

1611. Qing-Rui Wu, Dan-Lin Zheng, Pei-Ming Liu, Hui Yang, Lu-An Li, Su-Juan Kuang, Ying-Yu Lai, Fang Rao, Yu-Mei Xue, Ji-Jin Lin, Shuang-Xin Liu, Chun-Bo Chen, Chun-Yu Deng

.

High glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy

Cell Death Dis.

2021 Feb 26;12(2):216. doi: 10.1038/s41419-021-03502-4.

(IF 6.304)

1612. Yanhong Yang, Changyuan Yang, Zili Lei, Hedong Rong, Siping Yu, Huijuan Wu, Lanxiang Yang, Yuting Lei, Wanwan Liu, Ya Nie, Jiamin Zhu, Jiao Guo

.

Cigarette smoking exposure breaks the homeostasis of cholesterol and bile acid metabolism and induces gut microbiota dysbiosis in mice with different diets

Toxicology.

2021 Feb 28;450:152678. doi: 10.1016/j.tox.2021.152678.

(IF 4.099)

1613. Tianyu Zou, Jielin Zhang, Yongxiu Liu, Yiming Zhang, Kazuo Sugimoto, Cheng Mei

.

Antidepressant-Like Effect of Geniposide in Mice Exposed to a Chronic Mild Stress Involves the microRNA-298-5p-Mediated Nox1

Front Mol Neurosci.

2021 Feb 3;13:131. doi: 10.3389/fnmol.2020.00131.

(IF 4.057)

1614. Zhiyuan Qin, Haihong Hu, Wen Sun, Lu Chen, Shengnan Jin, Qingwen Xu, Yuxi Liu, Lushan Yu, Su Zeng

.

miR-224-5p Contained in Urinary Extracellular Vesicles Regulates PD-L1 Expression by Inhibiting Cyclin D1 in Renal Cell Carcinoma Cells

Cancers (Basel).

2021 Feb 4;13(4):618. doi: 10.3390/cancers13040618.

1615. Shuang Shen, Juntao Luo, Jianping Ye

.

Artesunate alleviates schistosomiasis-induced liver fibrosis by downregulation of mitochondrial complex Ⅰ subunit NDUFB8 and complex Ⅲ subunit UQCRC2 in hepatic stellate cells

Acta Trop.

2021 Feb;214:105781. doi: 10.1016/j.actatropica.2020.105781.

(IF 2.555)

1616. Guiting Zhang, Qianqian Cai, Hong Zhou, Chao He, Yudan Chen, Peng Zhang, Ting Wang, Liangjie Xu, Jinchuan Yan

.

OxLDL/β2GPI/anti‑β2GPI Ab complex induces inflammatory activation via the TLR4/NF‑κB pathway in HUVECs

Mol Med Rep.

2021 Feb;23(2):148. doi: 10.3892/mmr.2020.11787.

(IF 2.1)

1617. Hongyan Zhang, Feng Su, Libo Huang, Boyu Li, Xuejun Yuan, Mingjiu Luo, Lijiang Ge

.

Effects of progesterone on the lipolysis of lipid droplets and prostaglandin E2 synthesis in murine cervical epithelial cells

Reprod Fertil Dev.

2021 Feb;33(3):209-219. doi: 10.1071/RD20195.

1618. Xiangke Cao, Qinghua Ma, Bin Wang, Qingqiang Qian, Ning Liu, Tiejun Liu, Xiaoliu Dong

.

Silencing long non-coding RNA MIAT ameliorates myocardial dysfunction induced by myocardial infarction via MIAT/miR-10a-5p/EGR2 axis

Aging (Albany NY).

2021 Mar 26;13(8):11188-11206. doi: 10.18632/aging.202785.

1619. Yanhua Guan, Xu Wang

.

Salvianic Acid A Regulates High-Glucose-Treated Endothelial Progenitor Cell Dysfunction via the AKT/Endothelial Nitric Oxide Synthase (eNOS) Pathway

Med Sci Monit.

2021 Mar 26;27:e928153. doi: 10.12659/MSM.928153.

1620. Xiaohan Gong, Jinzhi Zhang, Caiyun Ge, Yiwen Yi, Shiyun Dai, Guanlan Fan, Changrong Li, Yuanzhen Zhang, Hui Wang, Dan Xu

.

miRNA320a-3p/RUNX2 signal programming mediates the transgenerational inheritance of inhibited ovarian estrogen synthesis in female offspring rats induced by prenatal dexamethasone exposure

Pharmacol Res.

2021 Mar;165:105435. doi: 10.1016/j.phrs.2021.105435.

(IF 5.893)

1621. Chenye Tang, Yuntao Wu, Xiao Wang, Kean Chen, Zhiling Tang, Xiao Guo

.

LncRNA MAFG-AS1 regulates miR-125b-5p/SphK1 axis to promote the proliferation, migration, and invasion of bladder cancer cells

Hum Cell.

2021 Mar;34(2):588-597. doi: 10.1007/s13577-020-00470-3.

(IF 3.463)

1622. Tianji Lin, Nan Wu, Linhong Wang, Ruipeng Zhang, Ruolang Pan, Yun-Fang Chen

.

Inhibition of chondrocyte apoptosis in a rat model of osteoarthritis by exosomes derived from miR‑140‑5p‑overexpressing human dental pulp stem cells

Int J Mol Med.

2021 Mar;47(3):7. doi: 10.3892/ijmm.2020.4840.

(IF 3.098)

1623. Bobo Yang, Wenjun Zhao, Changsheng Yin, Yu Bai, Suhua Wang, Guangwei Xing, Fang Li, Jinsong Bian, Michael Aschner, Jiyang Cai, Haifeng Shi, Rongzhu Lu

.

Acute acrylonitrile exposure inhibits endogenous H2S biosynthesis in rat brain and liver: The role of CBS/3-MPST-H2S pathway in its astrocytic toxicity

Toxicology.

2021 Mar 15;451:152685. doi: 10.1016/j.tox.2021.152685.

(IF 4.099)

1624. H Guo, Y Wang, W Jia, L Liu

.

MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway

Physiol Res.

2021 Mar 17;70(1):67-78. doi: 10.33549/physiolres.934506.

(IF 1.655)

1625. Jun Li, Cuiting Zhao, Qing Zhu, Yonghuai Wang, Guangyuan Li, Xinxin Li, Yuhong Li, Nan Wu, Chunyan Ma

.

Sweroside Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress and Pyroptosis Partially via Modulation of the Keap1/Nrf2 Axis

Front Cardiovasc Med.

2021 Mar 19;8:650368. doi: 10.3389/fcvm.2021.650368.

1626. Wentao Shao, Jin Xu, Cheng Xu, Zhenkun Weng, Qian Liu, Xin Zhang, Jingjia Liang, Wenxiang Li, Yi Zhang, Zhaoyan Jiang, Aihua Gu

.

Early-life perfluorooctanoic acid exposure induces obesity in male offspring and the intervention role of chlorogenic acid

Environ Pollut.

2021 Mar 1;272:115974. doi: 10.1016/j.envpol.2020.115974.

(IF 6.792)

1627. Wenjie Su, Shikai Zhu, Kai Chen, Hongji Yang, Mingwu Tian, Qiang Fu, Ganggang Shi, Shijian Feng, Dianyun Ren, Xin Jin, Chong Yang

.

Overexpressed WDR3 induces the activation of Hippo pathway by interacting with GATA4 in pancreatic cancer

J Exp Clin Cancer Res.

2021 Mar 1;40(1):88. doi: 10.1186/s13046-021-01879-w.

1628. Kunhong Zhong, Yuelong Wang, Zeng Wang, Zongliang Zhang, Shasha Zhao, Hexian Li, Jianhan Huang, Wenhao Guo, Xi Zheng, Gang Guo, Liangxue Zhou, Hui Yang, Aiping Tong

.

AP-64, Encoded by C5orf46, Exhibits Antimicrobial Activity against Gram-Negative Bacteria

Biomolecules.

2021 Mar 24;11(4):485. doi: 10.3390/biom11040485.

(IF 4.082)

1629. Yu Xia, Lan-Xiang Huang, Hui Chen, Juan Li, Ke-Ke Chen, Hang Hu, Fu-Bing Wang, Zhao Ding, Shi-Shang Guo

.

Acoustic Droplet Vitrification Method for High-Efficiency Preservation of Rare Cells

ACS Appl Mater Interfaces.

2021 Mar 24;13(11):12950-12959. doi: 10.1021/acsami.1c01452.

1630. Mengmeng Yang, Yixin Cui, Jia Song, Chen Cui, Lingshu Wang, Kai Liang, Chuan Wang, Sha Sha, Qin He, Huiqing Hu, Xinghong Guo, Nan Zang, Lei Sun, Li Chen

.

Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1

Biochem Biophys Res Commun.

2021 Mar 26;546:74-82. doi: 10.1016/j.bbrc.2021.01.098.

1631. Jiucui Li, Kongmiao Lu, Fenglan Sun, Shanjuan Tan, Xiao Zhang, Wei Sheng, Wanming Hao, Min Liu, Weihong Lv, Wei Han

.

Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway

J Transl Med.

2021 Mar 2;19(1):96. doi: 10.1186/s12967-021-02745-1.

(IF 4.124)

1632. Bingbing Ma, Lin Zhang, Jiaolong Li, Tong Xing, Yun Jiang, Feng Gao

.

Dietary taurine supplementation ameliorates muscle loss in chronic heat stressed broilers via suppressing the perk signaling and reversing endoplasmic reticulum-stress-induced apoptosis

J Sci Food Agric.

2021 Mar 30;101(5):2125-2134. doi: 10.1002/jsfa.10835.

1633. Weiqi Sun, Zhijing Ni, Rui Li, Xiuli Chang, Weihua Li, Mingjun Yang, Zhijun Zhou

.

Flurochloridone induces Sertoli cell apoptosis through ROS-dependent mitochondrial pathway

Ecotoxicol Environ Saf.

2021 Mar 31;216:112183. doi: 10.1016/j.ecoenv.2021.112183.

1634. Di Meng, Hongying Pan, Youwei Chen, Jiexia Ding, Yining Dai

.

Roles and mechanisms of NRG1 in modulating the pathogenesis of NAFLD through ErbB3 signaling in hepatocytes (NRG1 modulates NAFLD through ErbB3 signaling)

Obes Res Clin Pract.

2021 Mar-Apr;15(2):145-151. doi: 10.1016/j.orcp.2021.01.003.

(IF 2.062)

1635. Bao-You Fan, Yi-Lin Pang, Wen-Xiang Li, Chen-Xi Zhao, Yan Zhang, Xu Wang, Guang-Zhi Ning, Xiao-Hong Kong, Chang Liu, Xue Yao, Shi-Qing Feng

.

Liproxstatin-1 is an effective inhibitor of oligodendrocyte ferroptosis induced by inhibition of glutathione peroxidase 4

Neural Regen Res.

2021 Mar;16(3):561-566. doi: 10.4103/1673-5374.293157.

(IF 3.171)

1636. Guopeng Lin, Xuzhi Wan, Dan Liu, Yuxi Wen, Chengfeng Yang, Chao Zhao

.

COL1A1 as a potential new biomarker and therapeutic target for type 2 diabetes

Pharmacol Res.

2021 Mar;165:105436. doi: 10.1016/j.phrs.2021.105436.

(IF 5.893)

1637. Yigao Wu, Wei Rong, Qin Jiang, Ruiquan Wang, Huilan Huang

.

Downregulation of lncRNA GAS5 Alleviates Hippocampal Neuronal Damage in Mice with Depression-Like Behaviors Via Modulation of MicroRNA-26a/EGR1 Axis

J Stroke Cerebrovasc Dis.

2021 Mar;30(3):105550. doi: 10.1016/j.jstrokecerebrovasdis.2020.105550.

1638. Yijiang Huang, Daosen Chen, Zijian Yan, Jingdi Zhan, Xinghe Xue, Xiaoyun Pan, Huachen Yu

.

LncRNA MEG3 Protects Chondrocytes From IL-1β-Induced Inflammation via Regulating miR-9-5p/KLF4 Axis

Front Physiol.

2021 Mar 11;12:617654. doi: 10.3389/fphys.2021.617654.

(IF 3.367)

1639. Hui-Qing Lin, Shao-Hua Dai, Wei-Cheng Liu, Xiang Lin, Ben-Tong Yu, Shi-Biao Chen, Sheng Liu, Hua Ling, Jian Tang

.

Effects of prolonged cold-ischemia on autophagy in the graft lung in a rat orthotopic lung transplantation model

Life Sci.

2021 Mar 1;268:118820. doi: 10.1016/j.lfs.2020.118820.

(IF 3.647)

1640. Liangping Zhao, Li Wang, Daimin Zhang, Yuqi Chen, Fulu Jin

.

Puerarin alleviates coronary heart disease via suppressing inflammation in a rat model

Gene.

2021 Mar 1;771:145354. doi: 10.1016/j.gene.2020.145354.

(IF 2.984)

1641. Xi Zhang, Yang Liu, Zhen Zhang, Juan Tan, Junjun Zhang, Hao Ou, Jie Li, Zewen Song

.

Multi-Omics Analysis of Anlotinib in Pancreatic Cancer and Development of an Anlotinib-Related Prognostic Signature

Front Cell Dev Biol.

2021 Mar 4;9:649265. doi: 10.3389/fcell.2021.649265.

(IF 5.201)

1642. Ye Yang, Zhen-Yu Sang, Jie Ma, Ya-Ping Zhu, Su-Fang Wu

.

KRAS, YWHAE, SP1 and MSRA as biomarkers in endometrial cancer

Transl Cancer Res.

2021 Mar;10(3):1295-1312. doi: 10.21037/tcr-20-2969.

(IF 0.986)

1643. Yu Han, Yu Tang, Shuge Sun, Tongchol Kim, Kwangjin Ju, Sanghyok Ri, Xueying Du, Weishang Zhou, Wei Shi, Shiguo Li, Guangxu Liu

.

Modulatory function of calmodulin on phagocytosis and potential regulation mechanisms in the blood clam Tegillarca granosa

Dev Comp Immunol.

2021 Mar;116:103910. doi: 10.1016/j.dci.2020.103910.

(IF 3.192)

1644. Dan Zhao, Yumei Li, Chunhong Peng, Jieru Lin, Fuxun Yu, Yichen Zhao, Xiangyan Zhang, Degang Zhao

.

Outer membrane protein a in Acinetobacter baumannii induces autophagy through mTOR signalling pathways in the lung of SD rats

Biomed Pharmacother.

2021 Mar;135:111034. doi: 10.1016/j.biopha.2020.111034.

(IF 4.545)

1645. Danling Chen, LinLi Xu, Jinhua Wu, Haiying Liang, Yuemei Liang, Guocheng Liu

.

Downregulating miR-96-5p promotes proliferation, migration, and invasion, and inhibits apoptosis in human trophoblast cells via targeting DDAH1

Reprod Biol.

2021 Mar;21(1):100474. doi: 10.1016/j.repbio.2020.100474.

(IF 1.862)

1646. Xiangming Xu, Jiao Nie, Lin Lu, Chao Du, Fansheng Meng, Duannuo Song

.

YAP-TEAD up-regulates IRS2 expression to induce and deteriorate oesophageal cancer

J Cell Mol Med.

2021 Mar;25(5):2584-2595. doi: 10.1111/jcmm.16266.

(IF 4.486)

1647. Jingjing Li, Changmai Chen, Wei Zhang, Jing'ai Bi, Guang Yang, Erguang Li

.

Salsalate reverses metabolic disorders in a mouse model of non-alcoholic fatty liver disease through AMPK activation and caspase-6 activity inhibition

Basic Clin Pharmacol Toxicol.

2021 Mar;128(3):394-409. doi: 10.1111/bcpt.13535.

1648. Feng Guo, Yingke Zhou, Hui Guo, Dianyun Ren, Xin Jin, Heshui Wu

.

NR5A2 transcriptional activation by BRD4 promotes pancreatic cancer progression by upregulating GDF15

Cell Death Discov.

2021 Apr 13;7(1):78. doi: 10.1038/s41420-021-00462-8.

1649. Li Wang, Long Wang, Dianfu Zhang, Sai Li, Jiaojiao Yin, Zhen Xu, Xuezhen Zhang

.

Effect of dietary selenium on postprandial protein deposition in the muscle of juvenile rainbow trout ( Oncorhynchus mykiss)

Br J Nutr.

2021 Apr 14;125(7):721-731. doi: 10.1017/S000711452000313X.

1650. Ziyu Li, Meige Zheng, Shuisheng Yu, Fei Yao, Yang Luo, Yanchang Liu, Dasheng Tian, Li Cheng, Juehua Jing

.

M2 Macrophages Promote PDGFRβ+ Pericytes Migration After Spinal Cord Injury in Mice via PDGFB/PDGFRβ Pathway

Front Pharmacol.

2021 Apr 15;12:670813. doi: 10.3389/fphar.2021.670813.

(IF 4.225)

1651. Ying Li, Yuhui Ouyang, Jian Jiao, Zhaojun Xu, Luo Zhang

.

Exposure to environmental black carbon exacerbates nasal epithelial inflammation via the reactive oxygen species (ROS)-nucleotide-binding, oligomerization domain-like receptor family, pyrin domain con

Int Forum Allergy Rhinol.

2021 Apr;11(4):773-783. doi: 10.1002/alr.22669.

1652. Li-Chao Yao, Xiu-Hua Jiang, Si-Si Yan, Wei Wang, Lun Wu, Lu-Lu Zhai, Feng Xiang, Tao Ji, Lin Ye, Zhi-Gang Tang

.

Four potential microRNAs affect the progression of pancreatic ductal adenocarcinoma by targeting MET via the PI3K/AKT signaling pathway

Oncol Lett.

2021 Apr;21(4):326. doi: 10.3892/ol.2021.12588.

(IF 2.311)

1653. Chuanbao Lin, Pengfei Qian, Yan Zhang, Zhihui Liu, Kun Dai, Dawei Sun

.

Plac1 promotes nasopharyngeal carcinoma cells proliferation, migration and invasion via Furin/NICD/PTEN pathway

Tissue Cell.

2021 Apr;69:101480. doi: 10.1016/j.tice.2020.101480.

(IF 1.837)

1654. Lulu Zhao, Shengnan Wang, Hong Liu, Xiaoli Du, Ren Bu, Bing Li, Ruilan Han, Jie Gao, Yang Liu, Jian Hao, Jianrong Zhao, Yan Meng, Gang Li

.

The Pharmacological Effect and Mechanism of Lanthanum Hydroxide on Vascular Calcification Caused by Chronic Renal Failure Hyperphosphatemia

Front Cell Dev Biol.

2021 Apr 13;9:639127. doi: 10.3389/fcell.2021.639127.

(IF 5.201)

1655. Menglin Wang, Xinxin Wu, Lu Yu, Zi-Yun Hu, Xiaobo Li, Xia Meng, Chun-Tao Lv, Gi-Young Kim, Yung Hyun Choi, Zhengya Wang, Hai-Wei Xu, Cheng-Yun Jin

.

LCT-3d Induces Oxidative Stress-Mediated Apoptosis by Upregulating Death Receptor 5 in Gastric Cancer Cells

Front Oncol.

2021 Apr 16;11:658608. doi: 10.3389/fonc.2021.658608.

(IF 4.848)

1656. Wen-Wen Wang, Ruiyu Han, Hai-Jun He, Jia Li, Si-Yan Chen, Yingying Gu, Chenglong Xie

.

Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson's disease models

Aging (Albany NY).

2021 Apr 20;13(8):11738-11751. doi: 10.18632/aging.202868.

1657. Fangbin Zhang, Yan Yan, Xinguang Cao, Jinping Zhang, Yingxia Li, Changqing Guo

.

Methylation of microRNA-338-5p by EED promotes METTL3-mediated translation of oncogene CDCP1 in gastric cancer

Aging (Albany NY).

2021 Apr 21;13(8):12224-12238. doi: 10.18632/aging.103822.

1658. Jian Liu, Xi-Xin Ji, Yang Fu, Wen-Chao Zhang, Hui-Fang Ji, Jian-Wei Liu, Xiao-Shu Cheng, Yi-Fei Dong

.

Early Passive Leg Movement Prevents Against the Development of Heart Failure With Preserved Ejection Fraction in Rats

Front Cardiovasc Med.

2021 Apr 21;8:655009. doi: 10.3389/fcvm.2021.655009.

1659. Mengqing Jiang, Xuejing Sun, Suzhen Liu, Yan Tang, Yunming Shi, Yuanyuan Bai, Yujie Wang, Qiong Yang, Qize Yang, Weihong Jiang, Hong Yuan, Qixia Jiang, Jingjing Cai

.

Caspase-11-Gasdermin D-Mediated Pyroptosis Is Involved in the Pathogenesis of Atherosclerosis

Front Pharmacol.

2021 Apr 26;12:657486. doi: 10.3389/fphar.2021.657486.

(IF 4.225)

1660. Juan Chang, Chengxu Ma, Huan Guo, Haiqiong Ran, Guolian Chen, Yingdong Li

.

Ultrafiltration Extract of Radix Angelica Sinensis and Radix Hedysari Attenuates Risk of Low-Dose X-Ray Radiation-Induced Myocardial Fibrosis In Vitro

Evid Based Complement Alternat Med.

2021 Apr 28;2021:5580828. doi: 10.1155/2021/5580828.

1661. Mingli Qu, Lei Wan, Muchen Dong, Yidi Wang, Lixin Xie, Qingjun Zhou

.

Hyperglycemia-induced severe mitochondrial bioenergetic deficit of lacrimal gland contributes to the early onset of dry eye in diabetic mice

Free Radic Biol Med.

2021 Apr;166:313-323. doi: 10.1016/j.freeradbiomed.2021.02.036.

1662. Baoming Xie, Mingqiu Zhao, Dan Song, Keke Wu, Lin Yi, Wenhui Li, Xiaoming Li, Kun Wang, Jinding Chen

.

Induction of autophagy and suppression of type I IFN secretion by CSFV

Autophagy.

2021 Apr;17(4):925-947. doi: 10.1080/15548627.2020.1739445.

(IF 9.77)

1663. Chenjing Wang, Xiaodong Nan, Shuyan Pei, Yu Zhao, Xiaokun Wang, Shijie Ma, Guoyan Ma

.

Salidroside and isorhamnetin attenuate urotensin II-induced inflammatory response in vivo and in vitro: Involvement in regulating the RhoA/ROCK II pathway

Oncol Lett.

2021 Apr;21(4):292. doi: 10.3892/ol.2021.12553.

(IF 2.311)

1664. Hanlin Ma, Fang Han, Xiaohui Yan, Gonghua Qi, Yingwei Li, Rongrong Li, Shi Yan, Cunzhong Yuan, Kun Song, Beihua Kong

.

PBK promotes aggressive phenotypes of cervical cancer through ERK/c-Myc signaling pathway

J Cell Physiol.

2021 Apr;236(4):2767-2781. doi: 10.1002/jcp.30134.

(IF 5.546)

1665. Qiang Zheng, Zhenning Liu, Haitao Shen, Xiao Hu, Min Zhao

.

Protective effect of toll-interacting protein overexpression against paraquat-induced lung injury in mice and A549 cells through inhibiting oxidative stress, inflammation, and NF-κB signaling pathway

Respir Physiol Neurobiol.

2021 Apr;286:103600. doi: 10.1016/j.resp.2020.103600.

1666. Xiaoxiao Fu, Yueyang Liu, Haonan Zhang, Xiangnan Yu, Xuemei Wang, Chunfu Wu, Jingyu Yang

.

Pseudoginsenoside F11 ameliorates the dysfunction of the autophagy-lysosomal pathway by activating calcineurin-mediated TFEB nuclear translocation in neuron during permanent cerebral ischemia

Exp Neurol.

2021 Apr;338:113598. doi: 10.1016/j.expneurol.2021.113598.

(IF 4.691)

1667. Kun Wu, Guoquan Tao, Ting Xu, Yuanyuan An, Xiangyou Yu, Yi Wang, Shaochuang Wang, Wen Guo, Long Ma

.

Downregulation of miR-497-5p prevents liver ischemia-reperfusion injury in association with MED1/TIMP-2 axis and the NF-κB pathway

FASEB J.

2021 Apr;35(4):e21180. doi: 10.1096/fj.202001029R.

(IF 4.966)

1668. Qiuling Jie, Fei Sun, Qi Li, Juan Zhu, Yunjian Wei, Huamei Yang, Ping Long, Zhen Wang, Xiaohui Yang, Dan Li, Liping Huang, Yanlin Ma

.

Downregulated ribosomal protein L39 inhibits trophoblast cell migration and invasion by targeting E-cadherin in the placenta of patients with preeclampsia

FASEB J.

2021 Apr;35(4):e21322. doi: 10.1096/fj.202002061R.

(IF 4.966)

1669. Weimin Zhang, Junqi Yang, Jia Liu, Xingyu Long, Xitong Zhang, Jianke Li, Chen Hou

.

Red yeast rice prevents chronic alcohol-induced liver disease by attenuating oxidative stress and inflammatory response in mice

J Food Biochem.

2021 Apr;45(4):e13672. doi: 10.1111/jfbc.13672.

(IF 1.662)

1670. Zuo Zhang, Hongli Zhou, Jiyin Zhou

.

Neuritin inhibits astrogliosis to ameliorate diabetic cognitive dysfunction

J Mol Endocrinol.

2021 Apr;66(4):259-272. doi: 10.1530/JME-20-0321.

(IF 3.562)

1671. Yue-Ming Yu, Liang Xu, Hao-Ran Li, Tie-Qi Zhang, Guang Qian, Ling-Feng Li, Ming-Hai Wang

.

IARS2 regulates proliferation, migration, and angiogenesis of human umbilical vein endothelial cells

Rev Assoc Med Bras (1992).

2021 Apr;67(4):555-560. doi: 10.1590/1806-9282.20201024.

1672. Shun Guo, Tao Yan, Lei Shi, An Liu, Tian Zhang, Yuan Xu, Wei Jiang, Qi Yang, Le Yang, Linna Liu, Rong Zhao, Song Zhang

.

Matrine, as a CaSR agonist promotes intestinal GLP-1 secretion and improves insulin resistance in diabetes mellitus

Phytomedicine.

2021 Apr;84:153507. doi: 10.1016/j.phymed.2021.153507.

(IF 4.268)

1673. Tao Wang, Li Wang, Yi Zhang, Jian Sun, Yilin Xie, Yan Yuan, Jianhong Gu, Jianchun Bian, Zongping Liu, Hui Zou

.

Puerarin Restores Autophagosome-Lysosome Fusion to Alleviate Cadmium-Induced Autophagy Blockade via Restoring the Expression of Rab7 in Hepatocytes

Front Pharmacol.

2021 Apr 14;12:632825. doi: 10.3389/fphar.2021.632825.

(IF 4.225)

1674. Dingding Gao, Nan Jin, Yixian Fu, Yueyue Zhu, Yujie Wang, Ting Wang, Yuehong Chen, Mingming Zhang, Qiang Xiao, Min Huang, Yingxia Li

.

Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors

Eur J Med Chem.

2021 Apr 15;216:113333. doi: 10.1016/j.ejmech.2021.113333.

(IF 5.572)

1675. Hang Xue, Ziyi Wu, Ying Xu, Qiushi Gao, Yahan Zhang, Chang Li, Ping Zhao

.

Dexmedetomidine post-conditioning ameliorates long-term neurological outcomes after neonatal hypoxic ischemia: The role of autophagy

Life Sci.

2021 Apr 1;270:118980. doi: 10.1016/j.lfs.2020.118980.

(IF 3.647)

1676. Yijin Wu, Min Wu, Jue Yang, Ying Li, Wenying Peng, Meifen Wu, Changjiang Yu, Miaoxian Fang

.

Silencing CircHIPK3 Sponges miR-93-5p to Inhibit the Activation of Rac1/PI3K/AKT Pathway and Improves Myocardial Infarction-Induced Cardiac Dysfunction

Front Cardiovasc Med.

2021 Apr 30;8:645378. doi: 10.3389/fcvm.2021.645378.

1677. Lujia Zhang, Ya Li, Litao Qin, Yu Wu, Bo Lei

.

Autosomal Recessive Retinitis Pigmentosa Associated with Three Novel REEP6 Variants in Chinese Population

Genes (Basel).

2021 Apr 7;12(4):537. doi: 10.3390/genes12040537.

1678. Mengyu Liu, Huifeng Pi, Yu Xi, Liting Wang, Li Tian, Mengyan Chen, Jia Xie, Ping Deng, Tao Zhang, Chao Zhou, Yidan Liang, Lei Zhang, Mindi He, Yonghui Lu, Chunhai Chen, Zhengping Yu, Zhou Zhou

.

KIF5A-dependent axonal transport deficiency disrupts autophagic flux in trimethyltin chloride-induced neurotoxicity

Autophagy.

2021 Apr;17(4):903-924. doi: 10.1080/15548627.2020.1739444.

(IF 9.77)

1679. Nier Cha, Baoqing Jia, Yinzai He, Wei Luan, Wenhua Bao, Xiuhua Han, Weishi Gao, Yanwei Gao

.

MicroRNA-124 suppresses the invasion and proliferation of breast cancer cells by targeting TFAP4

Oncol Lett.

2021 Apr;21(4):271. doi: 10.3892/ol.2021.12532.

(IF 2.311)

1680. Yan Zhou, Xiawei Ji, Jiajing Chen, Yaoyang Fu, Juewei Huang, Rui Guo, Jinhui Zhou, Jianke Cen, Qihao Zhang, Anne Chu, Yingpeng Huang, Changlong Xu, Fangyan Wang

.

Short-chain fatty acid butyrate: A novel shield against chronic gastric ulcer

Exp Ther Med.

2021 Apr;21(4):329. doi: 10.3892/etm.2021.9760.

(IF 1.785)

1681. Tong Lu, Tong Qiu, Bin Han, Yuanyong Wang, Xiao Sun, Yi Qin, Ao Liu, Nan Ge, Wenjie Jiao

.

Circular RNA circCSNK1G3 induces HOXA10 signaling and promotes the growth and metastasis of lung adenocarcinoma cells through hsa-miR-143-3p sponging

Cell Oncol (Dordr).

2021 Apr;44(2):297-310. doi: 10.1007/s13402-020-00565-x.

1682. Yunlin Ge, Shuchen Ding, Jiangbiao Feng, Jiangdong Du, Zenghui Gu

.

Diosgenin inhibits Wnt/β-catenin pathway to regulate the proliferation and differentiation of MG-63 cells

Cytotechnology.

2021 Apr;73(2):169-178. doi: 10.1007/s10616-021-00454-7.

(IF 1.777)

1683. Yu-Shuai Wang, Wei-Han Yang, Wei Gao, Lu Zhang, Fang Wei, Hang Liu, Shu-Ya Wang, Ying-Ying Li, Wei-Man Zhao, Tao Ma, Qingqing Wang

.

Combination and efficiency: preparation of dissolving microneedles array loaded with two active ingredients and its anti-pigmentation effects on guinea pigs

Eur J Pharm Sci.

2021 May 1;160:105749. doi: 10.1016/j.ejps.2021.105749.

(IF 3.616)

1684. Qingbiao Xu, Mingyang Hu, Min Li, Jinxiu Hou, Xianghua Zhang, Ya Gao, Bahram Chachar, Xiang Li

.

Dietary Bioactive Peptide Alanyl-Glutamine Attenuates Dextran Sodium Sulfate-Induced Colitis by Modulating Gut Microbiota

Oxid Med Cell Longev.

2021 May 8;2021:5543003. doi: 10.1155/2021/5543003.

(IF 5.076)

1685. Kun-Yi Li, Xiao-Jiao Xiang, Li Song, Jian Chen, Biao Luo, Qi-Xin Wen, Bi-Rou Zhong, Gui-Feng Zhou, Xiao-Juan Deng, Yuan-Lin Ma, Li-Tian Hu, Guo-Jun Chen

.

Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression

J Neurochem.

2021 May;157(4):1351-1365. doi: 10.1111/jnc.15184.

(IF 4.066)

1686. Bi-Rou Zhong, Gui-Feng Zhou, Li Song, Qi-Xin Wen, Xiao-Juan Deng, Yuan-Lin Ma, Li-Tian Hu, Guo-Jun Chen

.

TUFM is involved in Alzheimer's disease-like pathologies that are associated with ROS

FASEB J.

2021 May;35(5):e21445. doi: 10.1096/fj.202002461R.

(IF 4.966)

1687. Chao Ma, Long Teng, Ge Lin, Beibei Guo, Run Zhuo, Xiaowei Qian, Tuchen Guan, Ronghua Wu, Yan Liu, Mei Liu

.

L-leucine promotes axonal outgrowth and regeneration via mTOR activation

FASEB J.

2021 May;35(5):e21526. doi: 10.1096/fj.202001798RR.

(IF 4.966)

1688. Qun Zhao, Yun Bi, Jing Zhong, Xiang Li, Jian Guo, Ying-Xiang Liu, Long-Rui Pan, Yan Tan, Zhang-Shuang Deng, Xian-Jun Yu

.

10,11-dehydrocurvularin exerts antitumor effect against human breast cancer by suppressing STAT3 activation

Acta Pharmacol Sin.

2021 May;42(5):791-800. doi: 10.1038/s41401-020-0499-y.

(IF 5.064)

1689. Qinghui Jia, Haihua Zhang, Yongmei Su, Xin Liu, Jiangsong Bai, Wuying Lang, Qiumei Shi, Minshan Feng

.

Strictosamide alleviates the inflammation in an acute ulcerative colitis (UC) model

J Physiol Biochem.

2021 May;77(2):283-294. doi: 10.1007/s13105-021-00796-y.

(IF 2.952)

1690. Rong Jiang, Lei Han, Qianqian Gao, Jie Chao

.

ZC3H4 mediates silica-induced EndoMT via ER stress and autophagy

Environ Toxicol Pharmacol.

2021 May;84:103605. doi: 10.1016/j.etap.2021.103605.

1691. Shengwei Liu, Jingdong Liu, Yuchun Wang, Ling Deng, Sha Chen, Xuan Wang, Tianrui Zuo, Qingwen Hu, Jiangyan Rao, Qian Wang, Zhi Dong

.

Differentially expressed genes induced by β-caryophyllene in a rat model of cerebral ischemia-reperfusion injury

Life Sci.

2021 May 15;273:119293. doi: 10.1016/j.lfs.2021.119293.

(IF 3.647)

1692. Sheng Chang, Yang Cao

.

Sulfasalazine maintains blood-brain barrier integrity and relieves lipopolysaccharide-induced inflammation in hCMEC/D3 cells

Neuroreport.

2021 May 19;32(8):672-677. doi: 10.1097/WNR.0000000000001632.

(IF 1.394)

1693. Xupeng Mu, Meng Zhang, Anhui Wei, Fei Yin, Yan Wang, Kebang Hu, Jinlan Jiang

.

Doxorubicin and PD-L1 siRNA co-delivery with stem cell membrane-coated polydopamine nanoparticles for the targeted chemoimmunotherapy of PCa bone metastases

Nanoscale.

2021 May 21;13(19):8998-9008. doi: 10.1039/d0nr08024a.

(IF 6.895)

1694. Bing Zou, Tieqiu Huang, Dan Wu, Xiaomin Hu, Linghui Xiao, Chenxi Wang, Hongzhou Zhang, Jian Xiang, Chenkai Hu, Qinghua Wu, Tao Wu

.

Knockdown of ZFAS1 improved the cardiac function of myocardial infarction rats via regulating Wnt/β-catenin signaling pathway

Aging (Albany NY).

2021 May 5;13(9):12919-12928. doi: 10.18632/aging.202961.

1695. Jin-Jin Zhu, Bin-Yuan Yu, Xiao-Kai Huang, Min-Zhi He, Bin-Wen Chen, Ting-Ting Chen, Huang-Yi Fang, Shang-Qin Chen, Xiao-Qin Fu, Pei-Jun Li, Zhen-Lang Lin, Jiang-Hu Zhu

.

Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation

Oxid Med Cell Longev.

2021 May 8;2021:6654954. doi: 10.1155/2021/6654954.

(IF 5.076)

1696. Zejie Zuo, Fangfang Qi, Zhiwei Xing, Lifang Yuan, Yunjie Yang, Zitian He, Lihua Zhou, Zhibin Yao

.

Bacille Calmette-Guérin attenuates vascular amyloid pathology and maximizes synaptic preservation in APP/PS1 mice following active amyloid-β immunotherapy

Neurobiol Aging.

2021 May;101:94-108. doi: 10.1016/j.neurobiolaging.2021.01.001.

(IF 4.347)

1697. Yuanyuan Tu, E Song, Zhenzhen Wang, Na Ji, Linling Zhu, Kun Wang, Haotian Sun, Yuting Zhang, Qiujian Zhu, Xiaojuan Liu, Manhui Zhu

.

Melatonin attenuates oxidative stress and inflammation of Müller cells in diabetic retinopathy via activating the Sirt1 pathway

Biomed Pharmacother.

2021 May;137:111274. doi: 10.1016/j.biopha.2021.111274.

(IF 4.545)

1698. Li Wang, Dianfu Zhang, Sai Li, Long Wang, Jiaojiao Yin, Zhen Xu, Xuezhen Zhang

.

Dietary Selenium Promotes Somatic Growth of Rainbow Trout (Oncorhynchus mykiss) by Accelerating the Hypertrophic Growth of White Muscle

Biol Trace Elem Res.

2021 May;199(5):2000-2011. doi: 10.1007/s12011-020-02282-w.

(IF 2.639)

1699. Ying Wang, Zhiquan Yang, Kai Zhang, Yi Wan, Yu Zhou, Zhuanyi Yang

.

miR-135a-5p inhibitor protects glial cells against apoptosis via targeting SIRT1 in epilepsy

Exp Ther Med.

2021 May;21(5):431. doi: 10.3892/etm.2021.9848.

(IF 1.785)

1700. Lei Zhang, Shuge Ouyang, Hongbo Zhang, Mingke Qiu, Yuxin Dai, Shuqing Wang, Yang Wang, Jingmin Ou

.

Graphene oxide induces dose-dependent lung injury in rats by regulating autophagy

Exp Ther Med.

2021 May;21(5):462. doi: 10.3892/etm.2021.9893.

(IF 1.785)

1701. Huiting Sun, Yichao Shi, Yuwei Shang, Xia Chen, Fei Xia

.

MicroRNA‑378d inhibits Glut4 by targeting Rsbn1 in vitamin D deficient ovarian granulosa cells

Mol Med Rep.

2021 May;23(5):369. doi: 10.3892/mmr.2021.12008.

(IF 2.1)

1702. Yuqiong Chen, Su Li, Yan Zhang, Mengshen Wang, Xinyan Li, Shuang Liu, Dengyue Xu, Yandong Bao, Pengyu Jia, Nan Wu, Yao Lu, Dalin Jia

.

The lncRNA Malat1 regulates microvascular function after myocardial infarction in mice via miR-26b-5p/Mfn1 axis-mediated mitochondrial dynamics

Redox Biol.

2021 May;41:101910. doi: 10.1016/j.redox.2021.101910.

(IF 9.986)

1703. Mengyuan Cen, Wei Ouyang, Wanying Zhang, Liping Yang, Xiuhui Lin, Min Dai, Huiqun Hu, Huifang Tang, Hongyun Liu, Jingyan Xia, Feng Xu

.

MitoQ protects against hyperpermeability of endothelium barrier in acute lung injury via a Nrf2-dependent mechanism

Redox Biol.

2021 May;41:101936. doi: 10.1016/j.redox.2021.101936.

(IF 9.986)

1704. Xiaolong Sun, Xu Wang, Zhenyu Zhao, Jing Chen, Cheng Li, Gang Zhao

.

Paeoniflorin inhibited nod-like receptor protein-3 inflammasome and NF-κB-mediated inflammatory reactions in diabetic foot ulcer by inhibiting the chemokine receptor CXCR2

Drug Dev Res.

2021 May;82(3):404-411. doi: 10.1002/ddr.21763.

1705. Qi Guo, Zejian Zhu, Jing Wang, Wei Huang, Chao Zhang, Jie Zeng, Haijian Zhao, Tianqi Qi, Weiyan Zhou, Tianjiao Zhang, Chuanbao Zhang, Fei Xiao

.

Preparation, stability and commutability of candidate reference materials for lactate dehydrogenase (LDH)

Clin Biochem.

2021 May;91:45-51. doi: 10.1016/j.clinbiochem.2021.02.002.

(IF 2.573)

1706. Yin Li, Hao Sheng, Feng Ma, Qiang Wu, Jianfang Huang, Qiang Chen, Lianghe Sheng, Xinghai Zhu, Xiaoxi Zhu, Meng Xu

.

RNA m6A reader YTHDF2 facilitates lung adenocarcinoma cell proliferation and metastasis by targeting the AXIN1/Wnt/β-catenin signaling

Cell Death Dis.

2021 May 13;12(5):479. doi: 10.1038/s41419-021-03763-z.

(IF 6.304)

1707. Shengqiang Li, Zhen Lei, Meng Zhao, Yonghao Hou, Di Wang, Xingli Xu, Xiaowen Lin, Jingxin Li, Shuhai Tang, Jingui Yu, Tao Meng

.

Propofol Inhibits Ischemia/Reperfusion-Induced Cardiotoxicity Through the Protein Kinase C/Nuclear Factor Erythroid 2-Related Factor Pathway

Front Pharmacol.

2021 May 13;12:655726. doi: 10.3389/fphar.2021.655726.

(IF 4.225)

1708. Meixuan Chen, Shuo Wu, Bing Shen, Qingquan Fan, Ran Zhang, Yu Zhou, Pingping Zhang, Liecheng Wang, Lesha Zhang

.

Activation of the δ opioid receptor relieves cerebral ischemic injury in rats via EGFR transactivation

Life Sci.

2021 May 15;273:119292. doi: 10.1016/j.lfs.2021.119292.

(IF 3.647)

1709. Liu Li, Li Yang, Feng Yang, Xin-Lan Zhao, Shengjiang Xue, Fang-Hua Gong

.

Ginkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice

J Inflamm Res.

2021 May 17;14:1959-1971. doi: 10.2147/JIR.S302934.

1710. Fanxing Meng, Jiayi Qiu, Houjie Chen, Xiaojun Shi, Meifang Yin, Meishu Zhu, Guang Yang

.

Dietary supplementation with N-3 polyunsaturated fatty acid-enriched fish oil promotes wound healing after ultraviolet B-induced sunburn in mice

Food Sci Nutr.

2021 May 17;9(7):3693-3700. doi: 10.1002/fsn3.2330.

(IF 1.797)

1711. Ke Wu, Xinyi Zheng, Zhixian Yao, Zhong Zheng, Wenjie Huang, Xingyu Mu, Feng Sun, Zhihong Liu, Junhua Zheng

.

Accumulation of CD45RO+CD8+ T cells is a diagnostic and prognostic biomarker for clear cell renal cell carcinoma

Aging (Albany NY).

2021 May 19;13(10):14304-14321. doi: 10.18632/aging.203045.

1712. Song Xue, Hanfei Tang, Gefei Zhao, Chao Fang, Yang Shen, Dong Yan, Ye Yuan, Weiguo Fu, Zhenyu Shi, Xiao Tang, Daqiao Guo

.

C-C motif ligand 8 promotes atherosclerosis via NADPH oxidase 2/reactive oxygen species-induced endothelial permeability increase

Free Radic Biol Med.

2021 May 1;167:181-192. doi: 10.1016/j.freeradbiomed.2021.02.022.

1713. Xiaolei Hu, Ling Xu, Xuewei Fu, Jiao Huang, Ping Ji, Zhiwei Zhang, Feng Deng, Xiaomian Wu

.

The TiO2-μ implant residual is more toxic than the Al2O3-n implant residual via blocking LAP and inducing macrophage polarization

Nanoscale.

2021 May 20;13(19):8976-8990. doi: 10.1039/d1nr00696g.

(IF 6.895)

1714. Ming Deng, Ping Xie, Zhonghui Chen, Yan Zhou, Junqi Liu, Jianghua Ming, Jianwei Yang

.

Mash-1 modified neural stem cells transplantation promotes neural stem cells differentiation into neurons to further improve locomotor functional recovery in spinal cord injury rats

Gene.

2021 May 20;781:145528. doi: 10.1016/j.gene.2021.145528.

(IF 2.984)

1715. Ruye Ma, Dandan Yu, Yu Peng, Hongfei Yi, Yingcong Wang, Taofang Cheng, Bingqing Shi, Guang Yang, Weiming Lai, Xiaosong Wu, Ye Lu, Jumei Shi

.

Resveratrol induces AMPK and mTOR signaling inhibition-mediated autophagy and apoptosis in multiple myeloma cells

Acta Biochim Biophys Sin (Shanghai).

2021 May 21;53(6):775-783. doi: 10.1093/abbs/gmab042.

1716. Dongrui Zhou, Kai Cen, Wei Liu, Fengzhi Liu, Ruijia Liu, Yikun Sun, Yizhou Zhao, Jingling Chang, Lingqun Zhu

.

Xuesaitong exerts long-term neuroprotection for stroke recovery by inhibiting the ROCKII pathway, in vitro and in vivo

J Ethnopharmacol.

2021 May 23;272:113943. doi: 10.1016/j.jep.2021.113943.

(IF 3.69)

1717. Duo Wen, Wan-Lin Liu, Zhong-Wu Lu, Yi-Ming Cao, Qing-Hai Ji, Wen-Jun Wei

.

SNHG9, a Papillary Thyroid Cancer Cell Exosome-Enriched lncRNA, Inhibits Cell Autophagy and Promotes Cell Apoptosis of Normal Thyroid Epithelial Cell Nthy-ori-3 Through YBOX3/P21 Pathway

Front Oncol.

2021 May 4;11:647034. doi: 10.3389/fonc.2021.647034.

(IF 4.848)

1718. Jiaying Wang, Conghui Wang, Yang Li, Mingyue Li, Tingjia Zhu, Zhangjin Shen, Hui Wang, Weiguo Lv, Xinyu Wang, Xiaodong Cheng, Xing Xie

.

Potential of peptide-engineered exosomes with overexpressed miR-92b-3p in anti-angiogenic therapy of ovarian cancer

Clin Transl Med.

2021 May;11(5):e425. doi: 10.1002/ctm2.425.

1719. Pengfei Zhao, Chaofei Wang, Jun Ding, Chengfeng Zhao, Yingjun Xia, Yanli Hu, Li Zhang, Yanqin Zhou, Junlong Zhao, Rui Fang

.

Evaluation of immunoprotective effects of recombinant protein and DNA vaccine based on Eimeria tenella surface antigen 16 and 22 in vivo

Parasitol Res.

2021 May;120(5):1861-1871. doi: 10.1007/s00436-021-07105-y.

(IF 1.641)

1720. Yixuan Wu, Zhigang Jiao, Zhiting Wan, Shaogang Qu

.

Role of autophagy and oxidative stress to astrocytes in fenpropathrin-induced Parkinson-like damage

Neurochem Int.

2021 May;145:105000. doi: 10.1016/j.neuint.2021.105000.

(IF 3.881)

1721. Xianming Chen, Yulin Zhang, Sen Zhang, Aiming Wang, Quanyin Du, Ziming Wang

.

Oleanolic acid inhibits osteosarcoma cell proliferation and invasion by suppressing the SOX9/Wnt1 signaling pathway

Exp Ther Med.

2021 May;21(5):443. doi: 10.3892/etm.2021.9883.

(IF 1.785)

1722. Feifei Shao, Lingmin Zhou, Yu Zhang, Hongping Chen, Yu Zhang, Zhihui Guan

.

Gastrodin alleviates inflammatory injury of cardiomyocytes in septic shock mice via inhibiting NLRP3 expression

In Vitro Cell Dev Biol Anim.

2021 May;57(5):571-581. doi: 10.1007/s11626-021-00593-3.

1723. Rutao Lin, Zixu Wang, Jing Cao, Ting Gao, Yulan Dong, Yaoxing Chen

.

Role of melatonin in murine "restraint stress"-induced dysfunction of colonic microbiota

J Microbiol.

2021 May;59(5):500-512. doi: 10.1007/s12275-021-0305-7.

(IF 2.845)

1724. Mengzhu Zheng, Junfeng Huo, Xiaoxia Gu, Yali Wang, Canrong Wu, Qingzhe Zhang, Wang Wang, Yang Liu, Yu Liu, Xuechen Zhou, Lixia Chen, Yirong Zhou, Hua Li

.

Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP

J Med Chem.

2021 Jun 10;64(11):7839-7852. doi: 10.1021/acs.jmedchem.1c00649.

(IF 6.205)

1725. Wei Zhang, Donge Tang, Liewen Lin, Tingting Fan, Ligang Xia, Wanxia Cai, Weier Dai, Chang Zou, Lianghong Yin, Yong Xu, Yong Dai

.

Integrative multiplatform-based molecular profiling of human colorectal cancer reveals proteogenomic alterations underlying mitochondrial inactivation

Am J Cancer Res.

2021 Jun 15;11(6):2893-2910.

(IF 5.177)

1726. Guanghua Yang, Chen Zeng, Yang Liu, Dongliang Li, Juanjuan Cui

.

ZNRD1-AS1 knockdown alleviates malignant phenotype of retinoblastoma through miR-128-3p/BMI1 axis

Am J Transl Res.

2021 Jun 15;13(6):5866-5879.

(IF 3.375)

1727. Wei Zhang, Liewen Lin, Ligang Xia, Wanxia Cai, Weier Dai, Chang Zou, Lianghong Yin, Donge Tang, Yong Xu, Yong Dai

.

Multi-omics analyses of human colorectal cancer revealed three mitochondrial genes potentially associated with poor outcomes of patients

J Transl Med.

2021 Jun 26;19(1):273. doi: 10.1186/s12967-021-02939-7.

(IF 4.124)

1728. Zili Lei, Huijuan Wu, Yanhong Yang, Qing Hu, Yuting Lei, Wanwan Liu, Ya Nie, Lanxiang Yang, Xueying Zhang, Changyuan Yang, Ting Lin, Fengxue Tong, Jiamin Zhu, Jiao Guo

.

Ovariectomy Impaired Hepatic Glucose and Lipid Homeostasis and Altered the Gut Microbiota in Mice With Different Diets

Front Endocrinol (Lausanne).

2021 Jun 30;12:708838. doi: 10.3389/fendo.2021.708838.

1729. Yan Hu, Bing Wang, Ke Yi, Qingjun Lei, Guanghui Wang, Xiaohui Xu

.

IFI35 is involved in the regulation of the radiosensitivity of colorectal cancer cells

Cancer Cell Int.

2021 Jun 3;21(1):290. doi: 10.1186/s12935-021-01997-7.

(IF 4.175)

1730. Liqiang Qi, Bo Sun, Beibei Yang, Su Lu

.

circHIPK3 (hsa_circ_0000284) Promotes Proliferation, Migration and Invasion of Breast Cancer Cells via miR-326

Onco Targets Ther.

2021 Jun 9;14:3671-3685. doi: 10.2147/OTT.S299190.

1731. Shaojian Chen, Zhihuan Luo, Xiaguang Chen

.

Hsa_circ_0044235 regulates the pyroptosis of rheumatoid arthritis via MiR-135b-5p-SIRT1 axis

Cell Cycle.

2021 Jun;20(12):1107-1121. doi: 10.1080/15384101.2021.1916272.

(IF 3.699)

1732. Yuan Gao, Xinjia Zhou, Yan Zhou, Wei Zhang, Li Zhao

.

Chrysene accelerates the proceeding of chronic obstructive pulmonary disease with the aggravation of inflammation and apoptosis in cigarette smoke exposed mice

Hum Exp Toxicol.

2021 Jun;40(6):1031-1044. doi: 10.1177/0960327120979343.

(IF 2.067)

1733. Mingdong Yu, Chao Qin, Pei Li, Yingli Zhang, Ying Wang, Jing Zhang, Dedong Li, Huixing Wang, Yuechun Lu, Keliang Xie, Yang Yu, Yonghao Yu

.

Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice

Int Immunopharmacol.

2021 Jun;95:107583. doi: 10.1016/j.intimp.2021.107583.

(IF 3.943)

1734. Qian Chai, Jiajing Miao, Meili Liu, Ziying Zhang, Ziang Meng, Weihua Wu

.

Knockdown of SGLT1 prevents the apoptosis of cardiomyocytes induced by glucose fluctuation via relieving oxidative stress and mitochondrial dysfunction

Biochem Cell Biol.

2021 Jun;99(3):356-363. doi: 10.1139/bcb-2020-0491.

(IF 2.46)

1735. Hengchen Liu, Mingzhao Zhang, Manyu Shi, Tingting Zhang, Wenjun Lu, Shulong Yang, Qingbo Cui, Zhaozhu Li

.

Adipose-derived mesenchymal stromal cell-derived exosomes promote tendon healing by activating both SMAD1/5/9 and SMAD2/3

Stem Cell Res Ther.

2021 Jun 10;12(1):338. doi: 10.1186/s13287-021-02410-w.

(IF 5.116)

1736. Xiao Liu, Ling Wang, Qunzhi Xing, Kehan Li, Jianluo Si, Xiaowu Ma, Lianjing Mao

.

Sevoflurane inhibits ferroptosis: A new mechanism to explain its protective role against lipopolysaccharide-induced acute lung injury

Life Sci.

2021 Jun 15;275:119391. doi: 10.1016/j.lfs.2021.119391.

(IF 3.647)

1737. Zongzhen Liao, Dihang Lin, Jirong Jia, Ran Cai, Yang Yu, Wensheng Li

.

Innate Immune Response to Fasting and Refeeding in the Zebrafish Kidney

Biomolecules.

2021 Jun 1;11(6):825. doi: 10.3390/biom11060825.

(IF 4.082)

1738. Qiang Zheng, Yuan Zhang, Zheng Zhao, Haitao Shen, Hongyu Zhao, Min Zhao

.

Isorhynchophylline ameliorates paraquat-induced acute kidney injury by attenuating oxidative stress and mitochondrial damage via regulating toll-interacting expression

Toxicol Appl Pharmacol.

2021 Jun 1;420:115521. doi: 10.1016/j.taap.2021.115521.

1739. Yun Long, Yi-Cheng Wang, Dong-Zhi Yuan, Xin-Hua Dai, Lin-Chuan Liao, Xue-Qin Zhang, Li-Xue Zhang, Yong-Dan Ma, Yi Lei, Zhi-Hui Cui, Jin-Hu Zhang, Li Nie, Li-Min Yue

.

GLUT4 in Mouse Endometrial Epithelium: Roles in Embryonic Development and Implantation

Front Physiol.

2021 Jun 25;12:674924. doi: 10.3389/fphys.2021.674924.

(IF 3.367)

1740. Jianqing Jiang, Mingsong Cai

.

Cardamonin Inhibited IL-1β Induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO-1 Signaling Pathway in Chondrocyte

J Microbiol Biotechnol.

2021 Jun 28;31(6):794-802. doi: 10.4014/jmb.2103.03057.

1741. Jinglin Ma, Yanrong Liu, Yongpeng Guo, Qiugang Ma, Cheng Ji, Lihong Zhao

.

Transcriptional Profiling of Aflatoxin B1-Induced Oxidative Stress and Inflammatory Response in Macrophages

Toxins (Basel).

2021 Jun 4;13(6):401. doi: 10.3390/toxins13060401.

1742. Qian Qu, Yan Li, Zhenyan Zhang, Hengzheng Cui, Qianqiu Zhao, Wanyue Liu, Tao Lu, Haifeng Qian

.

Effects of S-metolachlor on wheat (Triticum aestivum L.) seedling root exudates and the rhizosphere microbiome

J Hazard Mater.

2021 Jun 5;411:125137. doi: 10.1016/j.jhazmat.2021.125137.

(IF 9.038)

1743. Huiqiong Jiang, Jiaren Lv

.

MicroRNA-301a-3p increases oxidative stress, inflammation and apoptosis in ox-LDL-induced HUVECs by targeting KLF7

Exp Ther Med.

2021 Jun;21(6):569. doi: 10.3892/etm.2021.10001.

(IF 1.785)

1744. Tengfei Zhang, Danjie Guo, Weiping Zheng, Qunyun Dai

.

Effects of S1PR2 antagonist on blood pressure and angiogenesis imbalance in preeclampsia rats

Mol Med Rep.

2021 Jun;23(6):456. doi: 10.3892/mmr.2021.12095.

(IF 2.1)

1745. Yong Xu, Xiang Li, Hailun Li, Lili Zhong, Yongtao Lin, Juan Xie, Donghui Zheng

.

Circ_0023404 sponges miR-136 to induce HK-2 cells injury triggered by hypoxia/reoxygenation via up-regulating IL-6R

J Cell Mol Med.

2021 Jun;25(11):4912-4921. doi: 10.1111/jcmm.15986.

(IF 4.486)

1746. Jing Chen, Wenbin Shi, Yan Xu, Huaming Zhang, Bo Chen

.

Hirudin prevents vascular endothelial cell apoptosis and permeability enhancement induced by the serum from rat with chronic renal failure through inhibiting RhoA/ROCK signaling pathway

Drug Dev Res.

2021 Jun;82(4):553-561. doi: 10.1002/ddr.21773.

1747. Ling Zheng, Ya-Lin Jiang, Jun Fei, Peng Cao, Chen Zhang, Guo-Fang Xie, Li-Xiang Wang, Wei Cao, Lin Fu, Hui Zhao

.

Circulatory cadmium positively correlates with epithelial-mesenchymal transition in patients with chronic obstructive pulmonary disease

Ecotoxicol Environ Saf.

2021 Jun 1;215:112164. doi: 10.1016/j.ecoenv.2021.112164.

1748. Qingyun Zheng, Tianyi Wang, Xiangying Zhu, Xiao Tian, Chen Zhong, Guolin Chang, Gai Ran, Yilin Xie, Bing Zhao, Liqing Zhu, Chen Ling

.

Low endotoxin E. coli strain-derived plasmids reduce rAAV vector-mediated immune responses both in vitro and in vivo

Mol Ther Methods Clin Dev.

2021 Jun 24;22:293-303. doi: 10.1016/j.omtm.2021.06.009.

1749. Yaping Jiang, Xin Zhang, Xiaoyan Zhang, Kun Zhao, Jing Zhang, Chuanxi Yang, Yihui Chen

.

Comprehensive Analysis of the Transcriptome-Wide m6A Methylome in Pterygium by MeRIP Sequencing

Front Cell Dev Biol.

2021 Jun 25;9:670528. doi: 10.3389/fcell.2021.670528.

(IF 5.201)

1750. Shuaishuai Gong, Jincheng Liu, Shiyao Wan, Weiwei Yang, Yuanyuan Zhang, Boyang Yu, Fang Li, Junping Kou

.

Schisandrol A Attenuates Myocardial Ischemia/Reperfusion-Induced Myocardial Apoptosis through Upregulation of 14-3-3 θ

Oxid Med Cell Longev.

2021 Jun 26;2021:5541753. doi: 10.1155/2021/5541753.

(IF 5.076)

1751. Yi Jiang, Ming Shen, Yuanyuan Chen, Yinghui Wei, Jingli Tao, Honglin Liu

.

Melatonin Represses Mitophagy to Protect Mouse Granulosa Cells from Oxidative Damage

Biomolecules.

2021 Jun 30;11(7):968. doi: 10.3390/biom11070968.

(IF 4.082)

1752. Bin Zhai, Xiaohong Li, Cheng Lin, Peiyu Yan, Qun Zhao, Erchao Li

.

Proteomic analysis of hemocyte reveals the immune regulatory mechanisms after the injection of corticosteroid-releasing hormone in mud crab Scylla Paramamosain

J Proteomics.

2021 Jun 30;242:104238. doi: 10.1016/j.jprot.2021.104238.

(IF 3.509)

1753. Songsong Wang, Feiya Sheng, Liang Zou, Jianbo Xiao, Peng Li

.

Hyperoside attenuates non-alcoholic fatty liver disease in rats via cholesterol metabolism and bile acid metabolism

J Adv Res.

2021 Jun 8;34:109-122. doi: 10.1016/j.jare.2021.06.001.

(IF 6.992)

1754. Yubo Wang, Yuanyuan Zhou, Sheng Cao, Yue Sun, Zhiqiang Dong, Chen Li, Haoran Wang, Yuhong Yao, Haiyan Yu, Xiangyi Song, Ming Li, Jiefu Wang, Mingming Wei, Guang Yang, Cheng Yang

.

In vitro and in vivo degradation of programmed cell death ligand 1 (PD-L1) by a proteolysis targeting chimera (PROTAC)

Bioorg Chem.

2021 Jun;111:104833. doi: 10.1016/j.bioorg.2021.104833.

(IF 4.831)

1755. Guo-Liang Jiang, Xing-Long Yang, Hou-Jun Zhou, Jiang Long, Bin Liu, Lin-Ming Zhang, Di Lu

.

cGAS knockdown promotes microglial M2 polarization to alleviate neuroinflammation by inhibiting cGAS-STING signaling pathway in cerebral ischemic stroke

Brain Res Bull.

2021 Jun;171:183-195. doi: 10.1016/j.brainresbull.2021.03.010.

(IF 3.37)

1756. Yangyang Xia, Shouzhen Chen, Jianfeng Cui, Yong Wang, Xiaochen Liu, Yangli Shen, Li Gong, Xuewen Jiang, Wenfu Wang, Yaofeng Zhu, Shuna Sun, Jiangxia Li, Yongxin Zou, Benkang Shi

.

Berberine suppresses bladder cancer cell proliferation by inhibiting JAK1-STAT3 signaling via upregulation of miR-17-5p

Biochem Pharmacol.

2021 Jun;188:114575. doi: 10.1016/j.bcp.2021.114575.

(IF 4.96)

1757. Ke Xiao, Zhaogang Dong, Ding Wang, Min Liu, Juan Ding, Wendan Chen, Ziqi Shang, Congbo Yue, Yi Zhang

.

Clinical value of lncRNA CCAT1 in serum extracellular vesicles as a potential biomarker for gastric cancer

Oncol Lett.

2021 Jun;21(6):447. doi: 10.3892/ol.2021.12708.

(IF 2.311)

1758. Hui Yu, Zhe Zhang

.

ALKBH5-mediated m6A demethylation of lncRNA RMRP plays an oncogenic role in lung adenocarcinoma

Mamm Genome.

2021 Jun;32(3):195-203. doi: 10.1007/s00335-021-09872-6.

(IF 2.287)

1759. Guoli Li, Beibei Kong, Qingchao Tong, Yejia Li, Lifen Chen, Jin Zeng, Haitao Yu, Xinyou Xie, Jun Zhang

.

Vanillin downregulates NNMT and attenuates NNMT‑related resistance to 5‑fluorouracil via ROS‑induced cell apoptosis in colorectal cancer cells

Oncol Rep.

2021 Jun;45(6):110. doi: 10.3892/or.2021.8061.

(IF 3.417)

1760. Shu Wang, Yuqing Huang, Guangyan Luo, Xin Yang, Wei Huang

.

Cyanidin-3-O-glucoside attenuates high glucose-induced podocyte dysfunction by inhibiting apoptosis and promoting autophagy via activation of SIRT1/AMPK pathway

Can J Physiol Pharmacol.

2021 Jun;99(6):589-598. doi: 10.1139/cjpp-2020-0341.

1761. Jian-Ping Zhang, Wei-Jing Zhang, Miao Yang, Hua Fang

.

Propofol attenuates lung ischemia/reperfusion injury though the involvement of the MALAT1/microRNA-144/GSK3β axis

Mol Med.

2021 Jul 15;27(1):77. doi: 10.1186/s10020-021-00332-0.

(IF 4.096)

1762. Fan Zhang, Baoguo Zhang, Rong Tang, Haiping Jiang, Zhimin Ji, Yongjian Chen, Hao Feng

.

The occurrence of lupus nephritis is regulated by USP7-mediated JMJD3 stabilization

Immunol Lett.

2021 Jul;235:41-50. doi: 10.1016/j.imlet.2021.04.006.

(IF 3.276)

1763. Qi Li, Dongsheng Xu, Zehui Gu, Tengteng Li, Peng Huang, Liqun Ren

.

Rutin restrains the growth and metastasis of mouse breast cancer cells by regulating the microRNA-129-1-3p-mediated calcium signaling pathway

J Biochem Mol Toxicol.

2021 Jul;35(7):e22794. doi: 10.1002/jbt.22794.

1764. Ye Fang, Lin Zou, Wei He

.

miR‑30a‑5p mitigates autophagy by regulating the Beclin‑1/ATG16 pathway in renal ischemia/reperfusion injury

Int J Mol Med.

2021 Jul;48(1):144. doi: 10.3892/ijmm.2021.4977.

(IF 3.098)

1765. Jianzhang Zheng, Yunshuo Lin, Faqiang Tang, Huiling Guo, Laipeng Yan, Shiping Hu, Hong Wu

.

Promotive Role of CircATRNL1 on Chondrogenic Differentiation of BMSCs Mediated by miR-338-3p

Arch Med Res.

2021 Jul;52(5):514-522. doi: 10.1016/j.arcmed.2021.02.003.

(IF 2.093)

1766. Hailong Ruan, Lin Bao, Zhen Tao, Ke Chen

.

Flightless I Homolog Reverses Enzalutamide Resistance through PD-L1-Mediated Immune Evasion in Prostate Cancer

Cancer Immunol Res.

2021 Jul;9(7):838-852. doi: 10.1158/2326-6066.CIR-20-0729.

(IF 8.728)

1767. Haiyan Zhang, Zheng Wang, Zhengxia Liu, Kang Du, Xiang Lu

.

Protective Effects of Dexazoxane on Rat Ferroptosis in Doxorubicin-Induced Cardiomyopathy Through Regulating HMGB1

Front Cardiovasc Med.

2021 Jul 14;8:685434. doi: 10.3389/fcvm.2021.685434.

1768. Xuan Ju, Shengdong Wang, Pan Yan, Chunyan Zhu, Xiwen Hu, Jiezheng Dong, Zhonglin Tan

.

Rapid Eye Movement Sleep Deprivation Combined With Fluoxetine Protects Against Depression-Induced Damage and Apoptosis in Rat Hippocampi via A1 Adenosine Receptor

Front Psychiatry.

2021 Jul 16;12:599399. doi: 10.3389/fpsyt.2021.599399.

(IF 2.849)

1769. Kexin Wang, Yixin Cui, Peng Lin, Zhina Yao, Yu Sun

.

JunD Regulates Pancreatic β-Cells Function by Altering Lipid Accumulation

Front Endocrinol (Lausanne).

2021 Jul 16;12:689845. doi: 10.3389/fendo.2021.689845.

1770. Kun Zhang, Ming Xiao, Xin Jin, Hongyan Jiang

.

NR5A2 Is One of 12 Transcription Factors Predicting Prognosis in HNSCC and Regulates Cancer Cell Proliferation in a p53-Dependent Manner

Front Oncol.

2021 Jul 1;11:691318. doi: 10.3389/fonc.2021.691318.

(IF 4.848)

1771. Li Wang, Jiao-Jiao Yin, Feng Zhang, Hao-Dong Yu, Fei-Fei Chen, Zi-Yi Zhang, Xue-Zhen Zhang

.

Selenium Status Affects Hypertrophic Growth of Skeletal Muscle in Growing Zebrafish by Mediating Protein Turnover

J Nutr.

2021 Jul 1;151(7):1791-1801. doi: 10.1093/jn/nxab082.

(IF 4.281)

1772. Zhuo Li, Zhiying Miao, Linlin Ding, Xiaohua Teng, Jun Bao

.

Energy metabolism disorder mediated ammonia gas-induced autophagy via AMPK/mTOR/ULK1-Beclin1 pathway in chicken livers

Ecotoxicol Environ Saf.

2021 Jul 1;217:112219. doi: 10.1016/j.ecoenv.2021.112219.

1773. Ziyue Peng, Chengqiang Wang, Chun Liu, Haixia Xu, Yihan Wang, Yang Liu, Yunteng Hu, Jianjun Li, Yanglei Jin, Cong Jiang, Liangle Liu, Jiasong Guo, Lixin Zhu

.

3D printed polycaprolactone/beta-tricalcium phosphate/magnesium peroxide oxygen releasing scaffold enhances osteogenesis and implanted BMSCs survival in repairing the large bone defect

J Mater Chem B.

2021 Jul 21;9(28):5698-5710. doi: 10.1039/d1tb00178g.

(IF 5.344)

1774. Yaoyao Hou, Yingjun Fan, Xian Xia, Jicheng Pan, Jianjun Hou, Xixia Liu, Xinpeng Chen

.

USP31 acetylation at Lys1264 is essential for its activity and cervical cancer cell growth

Acta Biochim Biophys Sin (Shanghai).

2021 Jul 28;53(8):1037-1043. doi: 10.1093/abbs/gmab080.

1775. De-Bo Zou, Zongyou Mou, Wenliang Wu, Haichun Liu

.

TRIM33 protects osteoblasts from oxidative stress-induced apoptosis in osteoporosis by inhibiting FOXO3a ubiquitylation and degradation

Aging Cell.

2021 Jul;20(7):e13367. doi: 10.1111/acel.13367.

(IF 7.238)

1776. Lei Xu, Ying Xu, Jianbing Zheng, Yun Zhao, Hongcai Wang, Yushu Qi

.

Dacomitinib improves chemosensitivity of cisplatin-resistant human ovarian cancer cells

Oncol Lett.

2021 Jul;22(1):569. doi: 10.3892/ol.2021.12830.

(IF 2.311)

1777. Ting Luo, Dandan Lin, Yanan Hao, Rong Shi, Changwei Wei, Wenzhen Shen, Anshi Wu, Peili Huang

.

Ginkgolide B‑mediated therapeutic effects on perioperative neurocognitive dysfunction are associated with the inhibition of iNOS‑mediated production of NO

Mol Med Rep.

2021 Jul;24(1):537. doi: 10.3892/mmr.2021.12176.

(IF 2.1)

1778. Guanqun Cui, Ziyuan Li, Feifei Cao, Peng Li, Minghua Jin, Shanshan Hou, Xu Yang, Yingwen Mu, Cheng Peng, Hua Shao, Zhongjun Du

.

Activation of Nrf2/HO-1 signaling pathway attenuates ROS-mediated autophagy induced by silica nanoparticles in H9c2 cells

Environ Toxicol.

2021 Jul;36(7):1389-1401. doi: 10.1002/tox.23134.

(IF 3.118)

1779. Zhi-Bin Chen, Ge Li, Haocheng Lin, Jun Jiang, Rui Jiang

.

Low androgen status inhibits erectile function by increasing pyroptosis in rat corpus cavernosum

Andrology.

2021 Jul;9(4):1264-1274. doi: 10.1111/andr.12995.

(IF 2.86)

1780. Xintong Wang, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen

.

Melatonin Alleviates Acute Sleep Deprivation-Induced Memory Loss in Mice by Suppressing Hippocampal Ferroptosis

Front Pharmacol.

2021 Jul 16;12:708645. doi: 10.3389/fphar.2021.708645.

(IF 4.225)

1781. Hong-Xia Li, Xiao-Yan Liang, Jiong-He Wu, Ya-Ping Yuan, Yue Gao, Shao-Hua Cai

.

Simvastatin attenuates acute lung injury by activation of A2B adenosine receptor

Toxicol Appl Pharmacol.

2021 Jul 1;422:115460. doi: 10.1016/j.taap.2021.115460.

1782. Tingting Yu, Guangdi Zhou, Zhenzhen Cai, Wei Liang, Yatao Du, Weiye Wang

.

Behavioral effects of early-life exposure to perfluorooctanoic acid might synthetically link to multiple aspects of dopaminergic neuron development and dopamine functions in zebrafish larvae

Aquat Toxicol.

2021 Jul 24;238:105926. doi: 10.1016/j.aquatox.2021.105926.

(IF 4.344)

1783. Zhenwan Li, Jin Ma, Zhongsheng Kuang, Yong Jiang

.

β-Asarone Attenuates Aβ-Induced Neuronal Damage in PC12 Cells Overexpressing APPswe by Restoring Autophagic Flux

Front Pharmacol.

2021 Jul 28;12:701635. doi: 10.3389/fphar.2021.701635.

(IF 4.225)

1784. Tieying Hou, Long Ye, Shulin Wu

.

Knockdown of LINC00504 Inhibits the Proliferation and Invasion of Breast Cancer via the Downregulation of miR-140-5p

Onco Targets Ther.

2021 Jul 2;14:3991-4003. doi: 10.2147/OTT.S294965.

1785. Mengqiu Wu, Weiyi Chen, Mengqiu Miao, Qianqian Jin, Shengnan Zhang, Mi Bai, Jiaojiao Fan, Yue Zhang, Aihua Zhang, Zhanjun Jia, Songming Huang

.

Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability

Clin Sci (Lond).

2021 Jul 30;135(14):1707-1726. doi: 10.1042/CS20210100.

1786. Qinjie Liu, Jie Wu, Xufei Zhang, Xuanheng Li, Xiuwen Wu, Yun Zhao, Jianan Ren

.

Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury

Cell Death Dis.

2021 Jul 3;12(7):673. doi: 10.1038/s41419-021-03961-9.

(IF 6.304)

1787. Chengxiao Ma, Wen Zhang, Wengcong Wang, Jiabing Shen, Kefu Cai, Mei Liu, Maohong Cao

.

SKP-SCs transplantation alleviates 6-OHDA-induced dopaminergic neuronal injury by modulating autophagy

Cell Death Dis.

2021 Jul 5;12(7):674. doi: 10.1038/s41419-021-03967-3.

(IF 6.304)

1788. Hongyan Qu, Kai Shan, Chunlei Tang, Guozhen Cui, Guoling Fu, Yumin Qi, Jing Cui, Jiaqi Li, Rong Wang, Ninghan Feng, Yong Q Chen

.

A novel small-molecule fatty acid synthase inhibitor with antitumor activity by cell cycle arrest and cell division inhibition

Eur J Med Chem.

2021 Jul 5;219:113407. doi: 10.1016/j.ejmech.2021.113407.

(IF 5.572)

1789. Lei Zhang, Dingyu Hao, Pengyi Ma, Boyuan Ma, Jia Qin, Guangyuan Tian, Zihao Liu, Xianhu Zhou

.

Epitranscriptomic Analysis of m6A Methylome After Peripheral Nerve Injury

Front Genet.

2021 Jul 9;12:686000. doi: 10.3389/fgene.2021.686000.

(IF 3.258)

1790. Dezhi Li, Min Yan, Fengfei Sun, Junmei Song, Xingsheng Hu, Sijia Yu, Lina Tang, Shishan Deng

.

miR-498 inhibits autophagy and M2-like polarization of tumor-associated macrophages in esophageal cancer via MDM2/ATF3

Epigenomics.

2021 Jul;13(13):1013-1030. doi: 10.2217/epi-2020-0341.

(IF 4.112)

1791. Jinxiu Chu, Jian Wang, Lijuan Cui, Shuai Liu, Nina An, Jian Han, Xiaohang Che, Chunfu Wu, Jingyu Yang

.

Pseudoginsenoside-F11 ameliorates okadiac acid-induced learning and memory impairment in rats via modulating protein phosphatase 2A

Mech Ageing Dev.

2021 Jul;197:111496. doi: 10.1016/j.mad.2021.111496.

(IF 4.304)

1792. Jiujiao Gao, Peng Chu, Caigang Liu, Zhaolin Sun, Quentin Liu, Yongliang Yang

.

Discovery and biological evaluation of a small-molecule inhibitor of CRM1 that suppresses the growth of triple-negative breast cancer cells

Traffic.

2021 Jul;22(7):221-229. doi: 10.1111/tra.12802.

(IF 4.038)

1793. Song Tian, Yongjun Zheng, Shichu Xiao, Pengfei Luo, Rongju Sun, Jun Liu, Zhaofan Xia

.

Ivermectin inhibits cell proliferation and the expression levels of type I collagen, α‑SMA and CCN2 in hypertrophic scar fibroblasts

Mol Med Rep.

2021 Jul;24(1):488. doi: 10.3892/mmr.2021.12127.

(IF 2.1)

1794. Qian-Lan Xu, Jie Wu

.

Effects of Txk‑mediated activation of NF‑κB signaling pathway on neurological deficit and oxidative stress after ischemia‑reperfusion in rats

Mol Med Rep.

2021 Jul;24(1):524. doi: 10.3892/mmr.2021.12163.

(IF 2.1)

1795. Kai Hou, Jianliang Shen, Junrong Yan, Chuannan Zhai, Jingxia Zhang, Ji-An Pan, Ye Zhang, Yaping Jiang, Yongbo Wang, Richard Z Lin, Hongliang Cong, Shenglan Gao, Wei-Xing Zong

.

Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin

EBioMedicine.

2021 Jul;69:103456. doi: 10.1016/j.ebiom.2021.103456.

(IF 5.736)

1796. Fei-Yu Liu, Jing Wen, Jiong Hou, Si-Qi Zhang, Chun-Bin Sun, Luo-Chuan Zhou, Wen Yin, Wen-Lin Pang, Cui Wang, Yi Ying, Si-Si Han, Jin-Yuan Yan, Chen-Xi Li, Jia-Li Yuan, Hai-Jing Xing, Zhong-Shan Yang

.

Gastrodia remodels intestinal microflora to suppress inflammation in mice with early atherosclerosis

Int Immunopharmacol.

2021 Jul;96:107758. doi: 10.1016/j.intimp.2021.107758.

(IF 3.943)

1797. Xuelong Li, Jianmin Han, Ying Liu, Hui Liang

.

Lactobacillus casei relieves liver injury by regulating immunity and suppression of the enterogenic endotoxin-induced inflammatory response in rats cotreated with alcohol and iron

Food Sci Nutr.

2021 Aug 11;9(10):5391-5401. doi: 10.1002/fsn3.2486.

(IF 1.797)

1798. Xiankang Xu, Weixue Zhao, Yiru Ye, Weining Cui, Lu Dong, Yixin Yao, Kexuan Li, Jianzhong Han, Weilin Liu

.

Novel Nanoliposome Codelivered DHA and Anthocyanidin: Characterization, In Vitro Infant Digestibility, and Improved Cell Uptake

J Agric Food Chem.

2021 Aug 18;69(32):9395-9406. doi: 10.1021/acs.jafc.1c02817.

1799. Xiao Ma, Su Yang, Hesheng Jiang, Yujie Wang, Zhen Xiang

.

Transcriptomic analysis of tumor tissues and organoids reveals the crucial genes regulating the proliferation of lung adenocarcinoma

J Transl Med.

2021 Aug 26;19(1):368. doi: 10.1186/s12967-021-03043-6.

(IF 4.124)

1800. Lijun Kong, Hewei Zhang, Chaosheng Lu, Keqing Shi, Hongjian Huang, Yushu Zheng, Yongqiang Wang, Dan Wang, Hongwei Wang, Wei Huang

.

AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activa

Front Pharmacol.

2021 Aug 31;12:724514. doi: 10.3389/fphar.2021.724514.

(IF 4.225)

1801. Xiangyu Wu, Zitong Wang, Yanan Jiang, Hao Zhou, Ang Li, Yaxing Wei, Zhuo Bao, Donghao Wang, Jimin Zhao, Xinhuan Chen, Yaping Guo, Zigang Dong, Kangdong Liu

.

Tegaserod Maleate Inhibits Esophageal Squamous Cell Carcinoma Proliferation by Suppressing the Peroxisome Pathway

Front Oncol.

2021 Aug 4;11:683241. doi: 10.3389/fonc.2021.683241.

(IF 4.848)

1802. Yifan Ren, Qing Cui, Jia Zhang, Wuming Liu, Meng Xu, Yi Lv, Zheng Wu, Yuanyuan Zhang, Rongqian Wu

.

Milk Fat Globule-EGF Factor 8 Alleviates Pancreatic Fibrosis by Inhibiting ER Stress-Induced Chaperone-Mediated Autophagy in Mice

Front Pharmacol.

2021 Aug 5;12:707259. doi: 10.3389/fphar.2021.707259.

(IF 4.225)

1803. Min Zhu, Xing Zhang, Jun Pan, Hanxue Zhu, Ziyao Zhang, Zi Liang, Guangli Cao, Xiaolong Hu, Renyu Xue, Chengliang Gong

.

Tight junction protein claudin-2 promotes cell entry of Bombyx mori cypovirus

Appl Microbiol Biotechnol.

2021 Aug;105(14-15):6019-6031. doi: 10.1007/s00253-021-11456-y.

1804. Yirui Xie, Xiaozhu Chen, Xuying Zheng, Ling Li, Jieyin Li, Yuling Xu, Junbing He, Yao Lin

.

Beta1-integrin/Hedgehog-Gli1 signaling pathway fuels the diameter-dependent osteoblast differentiation on different TiO2 nanotubes: The optimal-diameter nanotubes for osteoblast differentiation

Int J Biochem Cell Biol.

2021 Aug;137:106026. doi: 10.1016/j.biocel.2021.106026.

1805. Yu Zhang, Fei Wang, Hao-Ran Sun, Ya-Kai Huang, Jian-Peng Gao, Hua Huang

.

Apatinib combined with PD-L1 blockade synergistically enhances antitumor immune responses and promotes HEV formation in gastric cancer

J Cancer Res Clin Oncol.

2021 Aug;147(8):2209-2222. doi: 10.1007/s00432-021-03633-3.

1806. Changliang Huo, Li Wang, Qiuli Wang, Yanbo Yang, Bo Chen

.

Hydroxysafflor Yellow A inhibits the viability and migration of vascular smooth muscle cells induced by serum from rats with chronic renal failure via inactivation of the PI3K/Akt signaling pathway

Exp Ther Med.

2021 Aug;22(2):850. doi: 10.3892/etm.2021.10282.

(IF 1.785)

1807. Jiani He, Zhongkai Qiu, Hao Zhang, Zhipeng Gao, Yuanjun Jiang, Zhenhua Li, Chuize Kong, Xiaojun Man

.

MicroRNA‑16‑5p/BIMP1/NF‑κB axis regulates autophagy to exert a tumor‑suppressive effect on bladder cancer

Mol Med Rep.

2021 Aug;24(2):576. doi: 10.3892/mmr.2021.12215.

(IF 2.1)

1808. Shu Zhang, Juanli Xing, Yulin Gong, Ping Li, Boqian Wang, Ling Xu

.

Downregulation of VDR in benign paroxysmal positional vertigo patients inhibits otolith‑associated protein expression levels

Mol Med Rep.

2021 Aug;24(2):591. doi: 10.3892/mmr.2021.12230.

(IF 2.1)

1809. Lulu Chen, Zixiang Chen, Zhuqiu Xu, Weifeng Feng, Xiaonan Yang, Zuoliang Qi

.

Polydatin protects Schwann cells from methylglyoxal induced cytotoxicity and promotes crushed sciatic nerves regeneration of diabetic rats

Phytother Res.

2021 Aug;35(8):4592-4604. doi: 10.1002/ptr.7177.

(IF 4.087)

1810. Yuan-Qi Li, Wei-Li Li, Xin-Hui Yu, Hua Wu, Yuan-Zhong Wang, Ya Jin, Le-le Hao, Ming-Min Liu, Xiao-Ge Song

.

Mechanisms of Traditional Chinese Medicine Bushenantai granules in promoting angiogenesis at the maternal-fetal interface of recurrent spontaneous abortion mice

J Tradit Chin Med.

2021 Aug;41(4):556-563. doi: 10.19852/j.cnki.jtcm.20210319.001.

(IF 0.676)

1811. Hailin Liu, Xiangnan Hu, Rong Jiang, Jianghui Cai, Qiao Lin, Zhiguo Fan, Pan Zhao, Song Wang, Chunqiao Zou, Weimin Du, Zhi Dong, Yingju Liu

.

CQMUH-011 Inhibits LPS-Induced Microglia Activation and Ameliorates Brain Ischemic Injury in Mice

Inflammation.

2021 Aug;44(4):1345-1358. doi: 10.1007/s10753-021-01420-3.

(IF 3.212)

1812. Yongxi Zhang, Shuyuan Liu, Tiesuo Zhao, Chengxue Dang

.

METTL3‑mediated m6A modification of Bcl‑2 mRNA promotes non‑small cell lung cancer progression

Oncol Rep.

2021 Aug;46(2):163. doi: 10.3892/or.2021.8114.

(IF 3.417)

1813. Yujie Zhong, Chengni Jin, Jiahui Han, Jiachang Zhu, Qi Liu, Dianjun Sun, Xiaodong Xia, Yu Zhang, Xiaoli Peng

.

Diosgenin Protects Against Kidney Injury and Mitochondrial Apoptosis Induced by 3-MCPD Through the Regulation of ER Stress, Ca2+ Homeostasis, and Bcl2 Expression

Mol Nutr Food Res.

2021 Aug;65(15):e2001202. doi: 10.1002/mnfr.202001202.

(IF 5.309)

1814. Xianyuan Zeng, Liang Lyu, Dousha Zhao, Jinying Zhong, Yan Feng, Haifu Wan, Chunyang Li, Ziping Zhang, Yilei Wang

.

dLp/HDL-BGBP and MTP Cloning and Expression Profiles During Embryonic Development in the Mud Crab Scylla paramamosain

Front Physiol.

2021 Aug 19;12:717751. doi: 10.3389/fphys.2021.717751.

(IF 3.367)

1815. Yu Chen, Ping Li, Yueting Peng, Xiaoxue Xie, Yixi Zhang, Ying Jiang, Tingting Li, Xiang Qin, Shun Li, Hong Yang, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Yiyao Liu

.

Protective autophagy attenuates soft substrate-induced apoptosis through ROS/JNK signaling pathway in breast cancer cells

Free Radic Biol Med.

2021 Aug 20;172:590-603. doi: 10.1016/j.freeradbiomed.2021.07.005.

1816. Xiang Chen, Hongyu Xie, Xin Wang, Zhinan Zheng, Sanqing Jin

.

CIRBP Knockdown Attenuates Tumourigenesis and Improves the Chemosensitivity of Pancreatic Cancer via the Downregulation of DYRK1B

Front Cell Dev Biol.

2021 Aug 20;9:667551. doi: 10.3389/fcell.2021.667551.

(IF 5.201)

1817. Chengpeng Zhao, Xiaoling Ling, Yunxia Xia, Bingxue Yan, Quanlin Guan

.

The m6A methyltransferase METTL3 controls epithelial-mesenchymal transition, migration and invasion of breast cancer through the MALAT1/miR-26b/HMGA2 axis

Cancer Cell Int.

2021 Aug 21;21(1):441. doi: 10.1186/s12935-021-02113-5.

(IF 4.175)

1818. Tongyao Wei, Heng Liu, Hongxiang Wu, Fan Pu, Xuechen Li

.

Serine/threonine ligation-assisted chemical synthesis of HMGA1a protein with site-specific post-translational modifications

STAR Protoc.

2021 Aug 25;2(3):100777. doi: 10.1016/j.xpro.2021.100777.

1819. Jun Zhang, Haiyan Wang, Xizhi Sun

.

Sevoflurane Postconditioning Reduces Hypoxia/Reoxygenation Injury in Cardiomyocytes via Upregulation of Heat Shock Protein 70

J Microbiol Biotechnol.

2021 Aug 28;31(8):1069-1078. doi: 10.4014/jmb.2103.03040.

1820. Bin Liu, Wei Gan, Zhang Jin, Meng Wang, Guopeng Cui, Hongyu Zhang, Huafu Wang

.

The Role of miR-34c-5p in Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells

Int J Stem Cells.

2021 Aug 30;14(3):286-297. doi: 10.15283/ijsc20188.

(IF 1.94)

1821. Xiaoya Wang, Man Xu, Qingbao Xu, Feng Yang, Hui Tang, Chuan Shao, Luyi Wang, Yan Wang, Jing Deng, Shali Wang

.

Rictor is involved in Ctnnd2 deletion-induced impairment of spatial learning and memory but not autism-like behaviors

Front Biosci (Landmark Ed).

2021 Aug 30;26(8):335-346. doi: 10.52586/4947.

1822. Lan Jiang, Qianhong Yang, Jianjun Gao, Jiahong Yang, Jiaqi He, Hong Xin, Xuemei Zhang

.

BK Channel Deficiency in Osteoblasts Reduces Bone Formation via the Wnt/β-Catenin Pathway

Mol Cells.

2021 Aug 31;44(8):557-568. doi: 10.14348/molcells.2021.0004.

(IF 4.081)

1823. Qian Zheng, Pengfei Li, Xin Zhou, Yulong Qiang, Jiachen Fan, Yan Lin, Yurou Chen, Jing Guo, Fan Wang, Haihua Xue, Jie Xiong, Feng Li

.

Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis

Theranostics.

2021 Aug 4;11(18):8674-8691. doi: 10.7150/thno.60233.

(IF 8.579)

1824. Chen Yu, Hengchang Zang, Cui Yang, Dong Liang, Shuang Quan, Danyang Li, Yanni Li, Qin Dong, Fengshan Wang, Lian Li

.

Study of chondroitin sulfate E oligosaccharide as a promising complement C5 inhibitor for osteoarthritis alleviation

Mater Sci Eng C Mater Biol Appl.

2021 Aug;127:112234. doi: 10.1016/j.msec.2021.112234.

1825. Wei Wang, Rui Wang, Zhijun Jiang, Haonan Li, Zemeng Zhu, Arslan Khalid, Dexiang Liu, Fang Pan

.

Inhibiting Brd4 alleviated PTSD-like behaviors and fear memory through regulating immediate early genes expression and neuroinflammation in rats

J Neurochem.

2021 Aug;158(4):912-927. doi: 10.1111/jnc.15439.

(IF 4.066)

1826. Ping Wang, Xinwei Hao, Xiaohan Li, Yizhi Yan, Wenxiu Tian, Lin Xiao, Zhenming Wang, Junhong Dong

.

Curcumin inhibits adverse psychological stress-induced proliferation and invasion of glioma cells via down-regulating the ERK/MAPK pathway

J Cell Mol Med.

2021 Aug;25(15):7190-7203. doi: 10.1111/jcmm.16749.

(IF 4.486)

1827. Ye Li, Xin Wei, Shu-Li Liu, Ying Zhao, Si Jin, Xiao-Yan Yang

.

Salidroside protects cardiac function in mice with diabetic cardiomyopathy via activation of mitochondrial biogenesis and SIRT3

Phytother Res.

2021 Aug;35(8):4579-4591. doi: 10.1002/ptr.7175.

(IF 4.087)

1828. Xu-Peng Wang, Wei-Chao Zheng, Yang Bai, Yan Li, Yue Xin, Jing-Zhou Wang, Yu-Lin Chang, Li-Min Zhang

.

Carbon Monoxide-Releasing Molecule-3 Alleviates Kupffer Cell Pyroptosis Induced by Hemorrhagic Shock and Resuscitation via sGC-cGMP Signal Pathway

Inflammation.

2021 Aug;44(4):1330-1344. doi: 10.1007/s10753-021-01419-w.

(IF 3.212)

1829. Jing Sun, Xiang Zhou, Jusheng Wu, Renjie Xiao, Yong Chen, Yimei Lu, Haili Lang

.

Ligustilide enhances hippocampal neural stem cells activation to restore cognitive function in the context of postoperative cognitive dysfunction

Eur J Neurosci.

2021 Aug;54(3):5000-5015. doi: 10.1111/ejn.15363.

(IF 3.115)

1830. Jingyi Mi, Yang Yang, Hao Yao, Zhirong Huan, Ce Xu, Zhiheng Ren, Wenfu Li, Ying Tang, Rao Fu, Xin Ge

.

Inhibition of heat shock protein family A member 8 attenuates spinal cord ischemia-reperfusion injury via astrocyte NF-κB/NLRP3 inflammasome pathway : HSPA8 inhibition protects spinal ischemia-reperfu

J Neuroinflammation.

2021 Aug 6;18(1):170. doi: 10.1186/s12974-021-02220-0.

1831. Hong Zhang, Mengyi Chi, Linlin Chen, Xipeng Sun, Lili Wan, Quanjun Yang, Cheng Guo

.

Daidzein alleviates cisplatin-induced muscle atrophy by regulating Glut4/AMPK/FoxO pathway

Phytother Res.

2021 Aug;35(8):4363-4376. doi: 10.1002/ptr.7132.

(IF 4.087)

1832. Runqing Huang, Jianxia Li, Yang Fu, Yanhong Deng

.

Downregulation of FEM1C enhances metastasis and proliferation in colorectal cancer

Ann Transl Med.

2021 Sep;9(17):1391. doi: 10.21037/atm-21-4244.

(IF 3.297)

1833. Hao Li, Wenchao Xu, Xiaming Liu, Tao Wang, Shaogang Wang, Jihong Liu, Hongyang Jiang

.

JAK2 deficiency improves erectile function in diabetic mice through attenuation of oxidative stress, apoptosis, and fibrosis

Andrology.

2021 Sep;9(5):1662-1671. doi: 10.1111/andr.13061.

(IF 2.86)

1834. Gui-Lin Jin, Li-Mian Hong, Hai-Ping Liu, Rong-Cai Yue, Zu-Cheng Shen, Jian Yang, Ying Xu, Hui-Hui Huang, Yi Li, Bo-Jun Xiong, Yan-Ping Su, Chang-Xi Yu

.

Koumine modulates spinal microglial M1 polarization and the inflammatory response through the Notch-RBP-Jκ signaling pathway, ameliorating diabetic neuropathic pain in rats

Phytomedicine.

2021 Sep;90:153640. doi: 10.1016/j.phymed.2021.153640.

(IF 4.268)

1835. Qingman Li, Lijie Zhu, Fangqing Niu, Qingmin Li, Che Wang, Honghui Yang, Chuanyu Gao

.

Histone deacetylase HDAC4 participates in the pathological process of myocardial ischemia-reperfusion injury via MEKK1/JNK pathway by binding to miR-206

Cell Death Discov.

2021 Sep 15;7(1):240. doi: 10.1038/s41420-021-00601-1.

1836. Ying Yuan, Chengcheng Zhu, Mingming Liu, Bilian Ke

.

Comparative proteome analysis of form-deprivation myopia in sclera with iTRAQ-based quantitative proteomics

Mol Vis.

2021 Sep 1;27:494-505.

(IF 2.202)

1837. Abdoulaye Issotina Zibrila, Zheng Wang, Md Ahasan Ali, James Ampofo Osei, Yuyao Sun, Salman Zafar, Kaili Liu, Chunfang Li, Yuming Kang, Jinjun Liu

.

Pyridostigmine ameliorates preeclamptic features in pregnant rats by inhibiting tumour necrosis factor-α synthetsis and antagonizing tumour necrosis factor-α-related effects

J Hypertens.

2021 Sep 1;39(9):1774-1789. doi: 10.1097/HJH.0000000000002932.

(IF 4.171)

1838. Yiliang Wang, Weisheng Luo, Lianzhou Huang, Ji Xiao, Xiaowei Song, Feng Li, Yuying Ma, Xiaohui Wang, Fujun Jin, Ping Liu, Yexuan Zhu, Kaio Kitazato, Yifei Wang, Zhe Ren

.

A novel lncRNA linc-AhRA negatively regulates innate antiviral response in murine microglia upon neurotropic herpesvirus infection

Theranostics.

2021 Sep 21;11(19):9623-9651. doi: 10.7150/thno.64880.

(IF 8.579)

1839. Ming Chang, Dan Zhu, Yanjiang Chen, Weiquan Zhang, Xi Liu, Xiao-Lan Li, Zhiping Cheng, Zhiheng Su, Jian Zhang, Yi Lu, Hongwei Guo

.

Total Flavonoids of Litchi Seed Attenuate Prostate Cancer Progression Via Inhibiting AKT/mTOR and NF-kB Signaling Pathways

Front Pharmacol.

2021 Sep 23;12:758219. doi: 10.3389/fphar.2021.758219.

(IF 4.225)

1840. Weihua Wu, Qian Chai, Ziying Zhang

.

Glucose fluctuation accelerates cardiac injury of diabetic mice via sodium-dependent glucose cotransporter 1 (SGLT1)

Arch Biochem Biophys.

2021 Sep 30;709:108968. doi: 10.1016/j.abb.2021.108968.

(IF 3.391)

1841. Lu Yao, Zhuoyan Fan, Shiwen Han, Na Sun, Huilian Che

.

Apigenin acts as a partial agonist action at estrogen receptors in vivo

Eur J Pharmacol.

2021 Sep 5;906:174175. doi: 10.1016/j.ejphar.2021.174175.

(IF 3.263)

1842. Rong Fan, Jidong Sui, Xuepeng Dong, Biao Jing, Zhenming Gao

.

Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis

Free Radic Biol Med.

2021 Sep;173:29-40. doi: 10.1016/j.freeradbiomed.2021.07.009.

1843. Xuejun Dai, Yanyu Guan, Zhongzi Zhang, Ying Xiong, Chengwei Liu, Haifeng Li, Bailian Liu

.

Comparison of the differentiation abilities of bone marrow-derived mesenchymal stem cells and adipose-derived mesenchymal stem cells toward nucleus pulposus-like cells in three-dimensional culture

Exp Ther Med.

2021 Sep;22(3):1018. doi: 10.3892/etm.2021.10450.

(IF 1.785)

1844. Kangjun Zhang, Taishi Fang, Yajie Shao, Yanhui Wu

.

TGF-β-MTA1-SMAD7-SMAD3-SOX4-EZH2 Signaling Axis Promotes Viability, Migration, Invasion and EMT of Hepatocellular Carcinoma Cells

Cancer Manag Res.

2021 Sep 10;13:7087-7099. doi: 10.2147/CMAR.S297765.

(IF 2.886)

1845. Xing Ge, Yong Zuo, Jinhong Xie, Xincheng Li, Yan Li, Anand Thirupathi, Peng Yu, Guofen Gao, Changhao Zhou, Yanzhong Chang, Zhenhua Shi

.

A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism

Aging (Albany NY).

2021 Sep 21;13(18):22375-22389. doi: 10.18632/aging.203544.

1846. Yike Wang, Lifeng Dong, Fang Wan, Fangfang Chen, Dianlei Liu, Deqin Chen, Jingpei Long

.

MiR-9-3p regulates the biological functions and drug resistance of gemcitabine-treated breast cancer cells and affects tumor growth through targeting MTDH

Cell Death Dis.

2021 Sep 22;12(10):861. doi: 10.1038/s41419-021-04145-1.

(IF 6.304)

1847. Qunqun Shan, Ning Li, Fan Zhang, Peng Yu, Qingxi Meng

.

Resveratrol Suppresses Annulus Fibrosus Cell Apoptosis through Regulating Oxidative Stress Reaction in an Inflammatory Environment

Biomed Res Int.

2021 Sep 27;2021:9100444. doi: 10.1155/2021/9100444.

(IF 2.276)

1848. Xing Xie, Fei Hao, Rong Chen, Jingjing Wang, Yanna Wei, Jin Liu, Haiyan Wang, Zhenzhen Zhang, Yun Bai, Guoqing Shao, Qiyan Xiong, Zhixin Feng

.

Nicotinamide Adenine Dinucleotide-Dependent Flavin Oxidoreductase of Mycoplasma hyopneumoniae Functions as a Potential Novel Virulence Factor and Not Only as a Metabolic Enzyme

Front Microbiol.

2021 Sep 29;12:747421. doi: 10.3389/fmicb.2021.747421.

(IF 4.235)

1849. Mian Wang, Yahui Zhu, Pei Wang, Zhenxin Gu, Runqiang Yang

.

Effect of γ-aminobutyric Acid on Phenolics Metabolism in Barley Seedlings under Low NaCl Treatment

Antioxidants (Basel).

2021 Sep 6;10(9):1421. doi: 10.3390/antiox10091421.

1850. Lili Jin, Yuxin Sun, Yuying Li, Hanyu Zhang, Wenxue Yu, Yiling Li, Yi Xin, Saeed Ali Alsareii, Qiuyu Wang, Dianbao Zhang

.

A synthetic peptide AWRK6 ameliorates metabolic associated fatty liver disease: involvement of lipid and glucose homeostasis

Peptides.

2021 Sep;143:170597. doi: 10.1016/j.peptides.2021.170597.

(IF 2.843)

1851. Liushan Chen, Linghao Qin, Chujun Chen, Qiong Hu, Junjian Wang, Juan Shen

.

Serum exosomes accelerate diabetic wound healing by promoting angiogenesis and ECM formation

Cell Biol Int.

2021 Sep;45(9):1976-1985. doi: 10.1002/cbin.11627.

(IF 2.571)

1852. Zhuo Gao, Xin Zhong, Ying-Xia Tan, Dong Liu

.

Apelin‑13 alleviates diabetic nephropathy by enhancing nitric oxide production and suppressing kidney tissue fibrosis

Int J Mol Med.

2021 Sep;48(3):175. doi: 10.3892/ijmm.2021.5008.

(IF 3.098)

1853. Tao Li, Bin Fu, Xin Zhang, Yunjiang Zhou, Mengdi Yang, Mengran Cao, Yaxin Chen, Yingying Tan, Rong Hu

.

Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation

Cancer Immunol Res.

2021 Sep;9(9):1008-1023. doi: 10.1158/2326-6066.CIR-20-1043.

(IF 8.728)

1854. Zhengtao Gu, Li Li, Qin Li, Hongping Tan, Zhimin Zou, Xueyong Chen, Zichen Zhang, Yijun Zhou, Danian Wei, Chengyong Liu, Qiaobing Huang, Marc Maegele, Daozhang Cai, Mingguang Huang

.

Polydatin alleviates severe traumatic brain injury induced acute lung injury by inhibiting S100B mediated NETs formation

Int Immunopharmacol.

2021 Sep;98:107699. doi: 10.1016/j.intimp.2021.107699.

(IF 3.943)

1855. Yue Xiong, Xiaochuan Cui, Yanjun Zhou, Gaoshang Chai, Xiufeng Jiang, Guizhi Ge, Yue Wang, Hongxu Sun, Huilian Che, Yunjuan Nie, Peng Zhao

.

Dehydrocostus lactone inhibits BLM-induced pulmonary fibrosis and inflammation in mice via the JNK and p38 MAPK-mediated NF-κB signaling pathways

Int Immunopharmacol.

2021 Sep;98:107780. doi: 10.1016/j.intimp.2021.107780.

(IF 3.943)

1856. Erping Xu, Baoying Wang, Shuaifei Lu, Changjing Zhang, Leilei Zhu, Xueying Liu, Ming Bai, Yucheng Li

.

Tandem mass tag-based quantitative proteomic analysis of the liver reveals potential protein targets of Xiaochaihutang in CUMS model of depression

J Chromatogr B Analyt Technol Biomed Life Sci.

2021 Sep 1;1181:122898. doi: 10.1016/j.jchromb.2021.122898.

1857. Liangbo Sun, Yangzhou Jiang, Xiaojing Yan, Xufang Dai, Chen Huang, Lingxi Chen, Tao Li, Yueting Zhang, Hanxi Xiao, Mingzhen Yang, Li Xiang, Yang Zhang, Sha Chen, Shuhui Li, An Chen, Fengtian He, Jiqin Lian

.

Dichloroacetate enhances the anti-tumor effect of sorafenib via modulating the ROS-JNK-Mcl-1 pathway in liver cancer cells

Exp Cell Res.

2021 Sep 1;406(1):112755. doi: 10.1016/j.yexcr.2021.112755.

(IF 3.383)

1858. Bo Liao, Mengtong Guan, Qiaoyan Tan, Gailan Wang, Ruobin Zhang, Junlan Huang, Mi Liu, Hong Chen, Kaiting Li, Dingqun Bai, Ying Zhu

.

Low-intensity pulsed ultrasound inhibits fibroblast-like synoviocyte proliferation and reduces synovial fibrosis by regulating Wnt/β-catenin signaling

J Orthop Translat.

2021 Sep 20;30:41-50. doi: 10.1016/j.jot.2021.08.002.

1859. Chao Zhang, Xiao-Chang Wu, Sha Li, Lian-Jie Dou, Li Zhou, Feng-Hui Wang, Kai Ma, Dan Huang, Ying Pan, Ji-Jun Gu, Ji-Yu Cao, Hua Wang, Jia-Hu Hao

.

Perinatal low-dose bisphenol AF exposure impairs synaptic plasticity and cognitive function of adult offspring in a sex-dependent manner

Sci Total Environ.

2021 Sep 20;788:147918. doi: 10.1016/j.scitotenv.2021.147918.

(IF 6.551)

1860. Tanjing Song, Qingli Zou, Yingying Yan, Suli Lv, Neng Li, Xuefeng Zhao, Xianyun Ma, Haigang Liu, Borui Tang, Lidong Sun

.

DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation

Cell Rep.

2021 Sep 21;36(12):109739. doi: 10.1016/j.celrep.2021.109739.

(IF 8.109)

1861. Chengyuan Yang, Cheng Gao, Naicheng Liu, Yitong Zhu, Xu Zhu, Xinlin Su, Qin Zhang, Yanglin Wu, Chenhui Zhang, Ang Liu, Weifeng Lin, Luyang Tao, Huilin Yang, Jun Lin

.

The effect of traumatic brain injury on bone healing from a novel exosome centered perspective in a mice model

J Orthop Translat.

2021 Sep 23;30:70-81. doi: 10.1016/j.jot.2021.09.003.

1862. Shuangqi Fan, Keke Wu, Mingqiu Zhao, Jin Yuan, Shengming Ma, Erpeng Zhu, Yuming Chen, Hongxing Ding, Lin Yi, Jinding Chen

.

LDHB inhibition induces mitophagy and facilitates the progression of CSFV infection

Autophagy.

2021 Sep;17(9):2305-2324. doi: 10.1080/15548627.2020.1823123.

(IF 9.77)

1863. Han Lu, Hui-Li Yang, Wen-Jie Zhou, Zhen-Zhen Lai, Xue-Min Qiu, Qiang Fu, Jian-Yuan Zhao, Jian Wang, Da-Jin Li, Ming-Qing Li

.

Rapamycin prevents spontaneous abortion by triggering decidual stromal cell autophagy-mediated NK cell residence

Autophagy.

2021 Sep;17(9):2511-2527. doi: 10.1080/15548627.2020.1833515.

(IF 9.77)

1864. Xintong Wang, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen

.

Melatonin ameliorates anxiety-like behaviors induced by sleep deprivation in mice: Role of oxidative stress, neuroinflammation, autophagy and apoptosis

Brain Res Bull.

2021 Sep;174:161-172. doi: 10.1016/j.brainresbull.2021.06.010.

(IF 3.37)

1865. Huaying Wang, Sai'nv Si, Mingjun Jiang, Liping Chen, Kefeng Huang, Wanjun Yu

.

Leukemia inhibitory factor is involved in the pathogenesis of NSCLC through activation of the STAT3 signaling pathway

Oncol Lett.

2021 Sep;22(3):663. doi: 10.3892/ol.2021.12924.

(IF 2.311)

1866. Nian Zhou, Bing Yan, Jing Ma, Hongchao Jiang, Li Li, Haoyu Tang, Fengming Ji, Zhigang Yao

.

Expression of TCF3 in Wilms' tumor and its regulatory role in kidney tumor cell viability, migration and apoptosis in vitro

Mol Med Rep.

2021 Sep;24(3):642. doi: 10.3892/mmr.2021.12281.

(IF 2.1)

1867. Wen-Juan Wang, Xia Jiang, Chang-Chun Gao, Zhi-Wei Chen

.

Salusin‑β participates in high glucose‑induced HK‑2 cell ferroptosis in a Nrf‑2‑dependent manner

Mol Med Rep.

2021 Sep;24(3):674. doi: 10.3892/mmr.2021.12313.

(IF 2.1)

1868. Hao Xu, Guo Wang, Yu-Yu Chi, Ya-Xin Kou, Yun Li

.

Expression profiling and functional characterization of the duplicated Oxr1b gene in zebrafish

Comp Biochem Physiol Part D Genomics Proteomics.

2021 Sep;39:100857. doi: 10.1016/j.cbd.2021.100857.

1869. Jian-Yi Dong, Kai-Jun Xia, Wei Liang, Lu-Lu Liu, Fang Yang, Xue-Sheng Fang, Yong-Jian Xiong, Liang Wang, Zi-Juan Zhou, Chang-Yi Li, Wei-Dong Zhang, Jing-Yu Wang, Da-Peng Chen

.

Ginsenoside Rb1 alleviates colitis in mice via activation of endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 signaling pathway

Acta Pharmacol Sin.

2021 Sep;42(9):1461-1471. doi: 10.1038/s41401-020-00561-9.

(IF 5.064)

1870. Tianyu Zheng, Jinrong Huang, Xi Xiang, Siyuan Li, Jiaying Yu, Kunli Qu, Zhe Xu, Peng Han, Zhanying Dong, Yang Liu, Fengping Xu, Huanming Yang, Marja Jäättelä, Yonglun Luo, Bin Liu

.

Systematical analysis reveals a strong cancer relevance of CREB1-regulated genes

Cancer Cell Int.

2021 Oct 12;21(1):530. doi: 10.1186/s12935-021-02224-z.

(IF 4.175)

1871. Ying Yang, Junjie Gu, Xuechun Li, Chunling Xue, Li Ba, Yang Gao, Jianfeng Zhou, Chunmei Bai, Zhao Sun, Robert Chunhua Zhao

.

HIF-1α promotes the migration and invasion of cancer-associated fibroblasts by miR-210

Aging Dis.

2021 Oct 1;12(7):1794-1807. doi: 10.14336/AD.2021.0315.

(IF 5.402)

1872. Yao Cheng, Yaru Cui, Yujie Zhai, Wenyu Xin, Yan Yu, Jia Liang, Shucui Li, Hongliu Sun

.

Neuroprotective Effects of Exogenous Irisin in Kainic Acid-Induced Status Epilepticus

Front Cell Neurosci.

2021 Oct 1;15:738533. doi: 10.3389/fncel.2021.738533.

(IF 3.921)

1873. Qiaofeng Li, Taijin Lan, Songhua He, Weiwei Chen, Xiaolan Li, Weiquan Zhang, Ying Liu, Qiuping Zhang, Xin Chen, Yaoyao Han, Zhiheng Su, Dan Zhu, Hongwei Guo

.

A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model

Chin Med.

2021 Oct 9;16(1):99. doi: 10.1186/s13020-021-00507-1.

1874. Ting-Ting Gong, Qian Guo, Xiao Li, Tie-Ning Zhang, Fang-Hua Liu, Xin-Hui He, Bei Lin, Qi-Jun Wu

.

Isothiocyanate Iberin inhibits cell proliferation and induces cell apoptosis in the progression of ovarian cancer by mediating ROS accumulation and GPX1 expression

Biomed Pharmacother.

2021 Oct;142:111533. doi: 10.1016/j.biopha.2021.111533.

(IF 4.545)

1875. Yuanyuan Lv, Yang Li, Jiangya Wang, Mei Li, Wenhao Zhang, Huifen Zhang, Ying Shen, Chao Li, Yuan Du, Lian Jiang

.

MiR-382-5p suppresses M1 macrophage polarization and inflammatory response in response to bronchopulmonary dysplasia through targeting CDK8: Involving inhibition of STAT1 pathway

Genes Cells.

2021 Oct;26(10):772-781. doi: 10.1111/gtc.12883.

(IF 1.655)

1876. Yang Zhao, Zhao Ding, Wenhao Ge, Junhao Liu, Xi Xu, Rui Cheng, Jianfa Zhang

.

Riclinoctaose Attenuates Renal Ischemia-Reperfusion Injury by the Regulation of Macrophage Polarization

Front Pharmacol.

2021 Oct 13;12:745425. doi: 10.3389/fphar.2021.745425.

(IF 4.225)

1877. Yi Luo, Xu Gao, Luetao Zou, Miao Lei, Junming Feng, Zhenming Hu

.

Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells

Oxid Med Cell Longev.

2021 Oct 18;2021:1783485. doi: 10.1155/2021/1783485.

(IF 5.076)

1878. Jin-Yu Liu, Ya-Jing Chen, Huan-Hui Feng, Zhan-Li Chen, Yun-Long Wang, Jin-E Yang, Shi-Mei Zhuang

.

LncRNA SNHG17 interacts with LRPPRC to stabilize c-Myc protein and promote G1/S transition and cell proliferation

Cell Death Dis.

2021 Oct 20;12(11):970. doi: 10.1038/s41419-021-04238-x.

(IF 6.304)

1879. Houkang Cao, Shaoyang Xi, Weiwei He, Xiaohui Ma, Li Liu, Jie Xu, Kefeng Zhang, Yingdong Li, Ling Jin

.

The effects of Gentiana dahurica Fisch on alcoholic liver disease revealed by RNA sequencing

J Ethnopharmacol.

2021 Oct 28;279:113422. doi: 10.1016/j.jep.2020.113422.

(IF 3.69)

1880. Tao Zhang, Sixia Chen, Yi Peng, Changgang Wang, Xi Cheng, Ren Zhao, Kun Liu

.

NOVA1-Mediated SORBS2 Isoform Promotes Colorectal Cancer Migration by Activating the Notch Pathway

Front Cell Dev Biol.

2021 Oct 8;9:673873. doi: 10.3389/fcell.2021.673873.

(IF 5.201)

1881. Lan Zhan, Xiangxiu Wang, Yanjing Zhang, Guonian Zhu, Yu Ding, Xuemei Chen, Wei Jiang, Sisi Wu

.

Benazepril hydrochloride protects against doxorubicin cardiotoxicity by regulating the PI3K/Akt pathway

Exp Ther Med.

2021 Oct;22(4):1082. doi: 10.3892/etm.2021.10516.

(IF 1.785)

1882. Jing-Hua Song, Hong-Yan Jia, Tian-Peng Shao, Zhi-Bao Liu, Yuan-Ping Zhao

.

Hydrogen gas post-conditioning alleviates cognitive dysfunction and anxiety-like behavior in a rat model of subarachnoid hemorrhage

Exp Ther Med.

2021 Oct;22(4):1121. doi: 10.3892/etm.2021.10555.

(IF 1.785)

1883. Rui Wang, Jingjing Xu, Jinbo Wu, Shunheng Gao, Zhiping Wang

.

Angiotensin-converting enzyme 2 alleviates pulmonary artery hypertension through inhibition of focal adhesion kinase expression

Exp Ther Med.

2021 Oct;22(4):1165. doi: 10.3892/etm.2021.10599.

(IF 1.785)

1884. Hui Li, Guilan Di, Yi Zhang, Junping Liang, Xianfeng Wang, Zhenshan Xu, Xianghui Kong

.

miR-217 through SIRT1 regulates the immunotoxicity of cadmium in Cyprinus carpio

Comp Biochem Physiol C Toxicol Pharmacol.

2021 Oct;248:109086. doi: 10.1016/j.cbpc.2021.109086.

1885. Jia-Bei Li, Wen-Song Xi, Shi-Ying Tan, Yuan-Yuan Liu, Hao Wu, Yuanfang Liu, Aoneng Cao, Haifang Wang

.

Effects of VO2 nanoparticles on human liver HepG2 cells: Cytotoxicity, genotoxicity, and glucose and lipid metabolism disorders

NanoImpact.

2021 Oct;24:100351. doi: 10.1016/j.impact.2021.100351.

1886. Rui Shi, Zirong Liu, Tong Liu

.

The antagonistic effect of bisphenol A and nonylphenol on liver and kidney injury in rats

Immunopharmacol Immunotoxicol.

2021 Oct;43(5):527-535. doi: 10.1080/08923973.2021.1950179.

1887. Guotao Huang, Ming Hu, Danhua Lu, Li Hong

.

Protective effect and potential mechanism of Schwann cell-derived exosomes on mechanical damage of rat dorsal root ganglion cells

J Obstet Gynaecol Res.

2021 Oct;47(10):3691-3701. doi: 10.1111/jog.14968.

1888. Yunlong Huang, Ran Ruan, Yanxin Fang, Kaiming Wu, Long Yao, Renquan Zhang, Wei He

.

GFI1 promotes the proliferation and migration of esophageal squamous cell carcinoma cells through the inhibition of SOCS1 expression

Int J Mol Med.

2021 Oct;48(4):184. doi: 10.3892/ijmm.2021.5017.

(IF 3.098)

1889. Xin Jin, Wan Fu, Jiaxiu Zhou, Niannian Shuai, Yan Yang, Bo Wang

.

Oxymatrine attenuates oxidized low‑density lipoprotein‑induced HUVEC injury by inhibiting NLRP3 inflammasome‑mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathway

Int J Mol Med.

2021 Oct;48(4):187. doi: 10.3892/ijmm.2021.5020.

(IF 3.098)

1890. Xin-Tian Zhang, Jing Hu, Li-Hua Su, Chang-An Geng, Ji-Jun Chen

.

Artematrolide A inhibited cervical cancer cell proliferation via ROS/ERK/mTOR pathway and metabolic shift

Phytomedicine.

2021 Oct;91:153707. doi: 10.1016/j.phymed.2021.153707.

(IF 4.268)

1891. Xuemei Piao, Jieru Zhou, Luan Xue

.

Triptolide decreases rheumatoid arthritis fibroblast-like synoviocyte proliferation, invasion, inflammation and presents a therapeutic effect in collagen-induced arthritis rats via inactivating lncRNA

Int Immunopharmacol.

2021 Oct;99:108010. doi: 10.1016/j.intimp.2021.108010.

(IF 3.943)

1892. Lingming Kong, Jie Deng, Xiang Zhou, Binbin Cai, Baofu Zhang, Xiaohu Chen, Zongjing Chen, Weiming Wang

.

Sitagliptin activates the p62-Keap1-Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury

Cell Death Dis.

2021 Oct 11;12(10):928. doi: 10.1038/s41419-021-04227-0.

(IF 6.304)

1893. Hewei Zhang, Lijun Kong, Yan Zhang, Cheng Wang, Linxiao Sun

.

Transcriptome and proteome analysis of the antitumor activity of maslinic acid against pancreatic cancer cells

Aging (Albany NY).

2021 Oct 12;13(19):23308-23327. doi: 10.18632/aging.203623.

1894. Naiyan Lu, Xinhe Wang, Wentao Shi, Lu Bian, Xuan Zhang, Guofeng Yang, Xue Tang, Jun Wang, Yin Zou, Yuyan Weng

.

Black Phosphorus Nanoparticles Promote Osteogenic Differentiation of EMSCs Through Upregulated TG2 Expression

Nanoscale Res Lett.

2021 Oct 12;16(1):154. doi: 10.1186/s11671-021-03610-2.

(IF 3.581)

1895. Peng Li, Zhiping Lin, Qianzheng Liu, Siyuan Chen, Xiang Gao, Weixiong Guo, Fan Gong, Jinsong Wei, Hao Lin

.

Enhancer RNA SLIT2 Inhibits Bone Metastasis of Breast Cancer Through Regulating P38 MAPK/c-Fos Signaling Pathway

Front Oncol.

2021 Oct 15;11:743840. doi: 10.3389/fonc.2021.743840.

(IF 4.848)

1896. Xiaoyong Zhao, Shan Li, Yunchang Mo, Ruru Li, Shaoyi Huang, Anqi Zhang, Xuqing Ni, Qinxue Dai, Junlu Wang

.

DCA Protects against Oxidation Injury Attributed to Cerebral Ischemia-Reperfusion by Regulating Glycolysis through PDK2-PDH-Nrf2 Axis

Oxid Med Cell Longev.

2021 Oct 19;2021:5173035. doi: 10.1155/2021/5173035.

(IF 5.076)

1897. Yan Fu, Yuexin Wei, Yu Zhou, Huan Wu, Yifan Hong, Chunlan Long, Junke Wang, Yuhao Wu, Shengde Wu, Lianju Shen, Guanghui Wei

.

Wnt5a Regulates Junctional Function of Sertoli cells Through PCP-mediated Effects on mTORC1 and mTORC2

Endocrinology.

2021 Oct 1;162(10):bqab149. doi: 10.1210/endocr/bqab149.

(IF 3.934)

1898. Huan Liu, Huidan Deng, Zhijie Jian, Hengmin Cui, Hongrui Guo, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao, Yanqiu Zhu

.

Copper exposure induces hepatic G0/G1 cell-cycle arrest through suppressing the Ras/PI3K/Akt signaling pathway in mice

Ecotoxicol Environ Saf.

2021 Oct 1;222:112518. doi: 10.1016/j.ecoenv.2021.112518.

1899. Wanbing He, Jieping Huang, Yang Liu, Changming Xie, Kun Zhang, Xinhong Zhu, Jie Chen, Hui Huang

.

Deletion of soluble epoxide hydrolase suppressed chronic kidney disease-related vascular calcification by restoring Sirtuin 3 expression

Cell Death Dis.

2021 Oct 23;12(11):992. doi: 10.1038/s41419-021-04283-6.

(IF 6.304)

1900. Guijuan Yu, Weihao Ou, Qinghui Ai, Wenbing Zhang, Kangsen Mai, Yanjiao Zhang

.

In vitro study of sodium butyrate on soyasaponin challenged intestinal epithelial cells of turbot ( Scophthalmus maximus L.) refer to inflammation, apoptosis and antioxidant enzymes

Fish Shellfish Immunol Rep.

2021 Oct 25;2:100031. doi: 10.1016/j.fsirep.2021.100031.

1901. Heqin Zhan, Feng Huang, Qian Niu, Mingli Jiao, Xumeng Han, Kaina Zhang, WenZhuo Ma, Shan Mi, Shiyu Guo, Zhenghang Zhao

.

Downregulation of miR-128 Ameliorates Ang II-Induced Cardiac Remodeling via SIRT1/PIK3R1 Multiple Targets

Oxid Med Cell Longev.

2021 Oct 4;2021:8889195. doi: 10.1155/2021/8889195.

(IF 5.076)

1902. Yanning Li, Yitong He, Haoliang Fan, Zhuo Wang, Jian Huang, Gehua Wen, Xiaohan Wang, Qiqian Xie, Pingming Qiu

.

Brain-derived neurotrophic factor upregulates synaptic GluA1 in the amygdala to promote depression in response to psychological stress

Biochem Pharmacol.

2021 Oct;192:114740. doi: 10.1016/j.bcp.2021.114740.

(IF 4.96)

1903. Yan Heng Zhao, Shun Wen Zhang, Hai Jun Zhao, Hui Yuan Qin, Fang Wu, Jie Zhang, Yu Qing Zhang, Xiao Ling Liu, Su Liang, Hui Zhang, Jiang Dong Wu, Zheng Yong Zhao, Hong Zhou Wang, Meng Shao, Jing Liu, Jiang Tao Dong, Wan Jiang Zhang

.

Gadolinium chloride pre-treatment reduces the inflammatory response and preserves intestinal barrier function in a rat model of sepsis

Exp Ther Med.

2021 Oct;22(4):1143. doi: 10.3892/etm.2021.10577.

(IF 1.785)

1904. Yang Kang, Minghui Bai, Liling Deng, Linbo Fan, Xing Wang

.

MiRNA-21 Regulates Bronchial Epithelial Cell Proliferation by Activating Tgfβ1/Smad Signaling Pathway and Its Correlation with Asthma Severity in Children

Iran J Public Health.

2021 Oct;50(10):1973-1982. doi: 10.18502/ijph.v50i10.7497.

(IF 1.291)

1905. Zhihong Lu, Xiujuan Zhu, Yuhong Ye, Haidong Fu, Jianhua Mao

.

PP2A protects podocytes against Adriamycin-induced injury and epithelial-to-mesenchymal transition via suppressing JIP4/p38-MAPK pathway

Cytotechnology.

2021 Oct;73(5):697-713. doi: 10.1007/s10616-021-00484-1.

(IF 1.777)

1906. Chunju Zheng, Ting Lu, Zhimin Fan

.

miR-200b-3p alleviates TNF-α-induced apoptosis and inflammation of intestinal epithelial cells and ulcerative colitis progression in rats via negatively regulating KHDRBS1

Cytotechnology.

2021 Oct;73(5):727-743. doi: 10.1007/s10616-021-00490-3.

(IF 1.777)

1907. Xiaoyue Zhang, Wendi Yang, Kehong Chen, Taihao Zheng, Zhengjun Guo, Yuan Peng, Zhenzhou Yang

.

The potential prognostic values of the ADAMTS-like protein family: an integrative pan-cancer analysis

Ann Transl Med.

2021 Oct;9(20):1562. doi: 10.21037/atm-21-4946.

(IF 3.297)

1908. Jie Zhou, Cheng Guo, Hao Wu, Bing Li, Li-Li Zhou, Ai-Bin Liang, Jian-Fei Fu

.

Dnmt3a is downregulated by Stat5a and mediates G0/G1 arrest by suppressing the miR-17-5p/Cdkn1a axis in Jak2V617F cells

BMC Cancer.

2021 Nov 13;21(1):1213. doi: 10.1186/s12885-021-08915-0.

(IF 3.15)

1909. Jiao Guo, Haiyu Yang, Ya Liu, Wei Liu, Ruiying Zhao, He Li, Wei Long, Wenqing Xu, Meili Guo, Xiaodong Zhang

.

Atomically precise silver clusterzymes protect mice from radiation damages

J Nanobiotechnology.

2021 Nov 19;19(1):377. doi: 10.1186/s12951-021-01054-5.

1910. Tong Wang, Guangyuan Wang, Guoli Zhang, Ranran Hou, Liwei Zhou, Xuemei Tian

.

Systematic analysis of the lysine malonylome in Sanghuangporus sanghuang

BMC Genomics.

2021 Nov 19;22(1):840. doi: 10.1186/s12864-021-08120-0.

(IF 3.594)

1911. Shaoqing Li, Wei An, Bin Wang, Jing Li, Yi Qu, Haoyang Zhang, Yingrui Zhang, Songlin Wang, Lizheng Qin

.

Inorganic nitrate alleviates irradiation-induced salivary gland damage by inhibiting pyroptosis

Free Radic Biol Med.

2021 Nov 1;175:130-140. doi: 10.1016/j.freeradbiomed.2021.08.227.

1912. Tianyi Ma, Xiaohui Huang, Haoxiao Zheng, Guolin Huang, Weiwen Li, Xinyue Liu, Jingjing Liang, Yue Cao, Yunzhao Hu, Yuli Huang

.

SFRP2 Improves Mitochondrial Dynamics and Mitochondrial Biogenesis, Oxidative Stress, and Apoptosis in Diabetic Cardiomyopathy

Oxid Med Cell Longev.

2021 Nov 8;2021:9265016. doi: 10.1155/2021/9265016.

(IF 5.076)

1913. Meng Wang, Lingchen Wang, Yuan Zhou, Xiaoxuan Feng, Chaoyang Ye, Chen Wang

.

Icariin attenuates renal fibrosis in chronic kidney disease by inhibiting interleukin-1β/transforming growth factor-β-mediated activation of renal fibroblasts

Phytother Res.

2021 Nov;35(11):6204-6215. doi: 10.1002/ptr.7256.

(IF 4.087)

1914. Dan Li, Yonghou Zhao, Peng Bai, Yan Li, Siqi Wan, Xi Zhu, Mengyu Liu

.

Baihui (DU20)-penetrating-Qubin (GB7) acupuncture regulates microglia polarization through miR-34a-5p/Klf4 signaling in intracerebral hemorrhage rats

Exp Anim.

2021 Nov 10;70(4):469-478. doi: 10.1538/expanim.21-0034.

1915. Youhua Liu, Yuanling Zhao, Ruifan Wu, Yushi Chen, Wei Chen, Yuxi Liu, Yaojun Luo, Chaoqun Huang, Botao Zeng, Xing Liao, Guanqun Guo, Yizhen Wang, Xinxia Wang

.

mRNA m5C controls adipogenesis by promoting CDKN1A mRNA export and translation

RNA Biol.

2021 Nov 12;18(sup2):711-721. doi: 10.1080/15476286.2021.1980694.

(IF 5.35)

1916. Yuyan Liao, Chenghao Kuang, Zheng Bao, Yijing He, Long Gu, Qianke Tao, Xiancheng Qiu, Ghosh Dipritu, Xi Kong, Lifang Zhang, Jianhua Peng, Yong Jiang, Shigang Yin

.

Nucleo-cytoplasmic RNA distribution responsible for maintaining neuroinflammatory microenvironment

RNA Biol.

2021 Nov 12;18(sup2):866-880. doi: 10.1080/15476286.2021.2004684.

(IF 5.35)

1917. Hua-Chun Weng, Xin-Yu Lu, Yu-Peng Xu, Yi-Hong Wang, Dan Wang, Yi-Ling Feng, Zhang Chi, Xiao-Qing Yan, Chao-Sheng Lu, Hong-Wei Wang

.

Fibroblast growth factor 21 attenuates salt-sensitive hypertension-induced nephropathy through anti-inflammation and anti-oxidation mechanism

Mol Med.

2021 Nov 13;27(1):147. doi: 10.1186/s10020-021-00408-x.

(IF 4.096)

1918. Jing He, Zhuang Wang, Yanbo Zhao, Jin Yang, Yuanxing Zhang, Qin Liu, Dahai Yang

.

Feeding with poly(I:C) induced long-term immune responses against bacterial infection in turbot ( Scophthalmus maximus)

Fish Shellfish Immunol Rep.

2021 Nov 14;2:100037. doi: 10.1016/j.fsirep.2021.100037.

1919. Yu Qian, Xinyu Lu, Lulu Chen, Jinyu Sun, Kan Cao, Qiang Yu, Junfei Shao

.

Effect of astaxanthin on neuron damage, inflammatory factors expressions and oxidative stress in mice with subarachnoid hemorrhage

Am J Transl Res.

2021 Nov 15;13(11):13043-13050.

(IF 3.375)

1920. Xinxin Wang, Haitao Gu, Kaichun Li, Jiayun Lin, Yiming Zhu, Wensheng Deng

.

DPP4 inhibitor reduces portal hypertension in cirrhotic rats by normalizing arterial hypocontractility

Life Sci.

2021 Nov 1;284:119895. doi: 10.1016/j.lfs.2021.119895.

(IF 3.647)

1921. Jingjing Wu, Mengyu Yao, Yonggang Zhang, Zefeng Lin, Wenwu Zou, Jiaping Li, Pamela Habibovic, Chang Du

.

Biomimetic three-layered membranes comprising (poly)-ε-caprolactone, collagen and mineralized collagen for guided bone regeneration

Regen Biomater.

2021 Nov 24;8(6):rbab065. doi: 10.1093/rb/rbab065.

(IF 4.882)

1922. Kun Zhang, Ran Liu, Jingruo Zhang, Xifang Wei, Yuan Gao, Wen Ma, Yijing Li, Wa Cai, Weidong Shen

.

Electroacupuncture Ameliorates Depression-Like Behaviour in Rats by Enhancing Synaptic Plasticity via the GluN2B/CaMKII/CREB Signalling Pathway

Evid Based Complement Alternat Med.

2021 Nov 3;2021:2146001. doi: 10.1155/2021/2146001.

1923. Jingtao Jiang, Chengji Dong, Liang Zhai, Junsheng Lou, Jie Jin, Sheng Cheng, Zhuliu Chen, Xiaoshan Guo, Damu Lin, Jian Ding, Weiyang Gao

.

Paeoniflorin Suppresses TBHP-Induced Oxidative Stress and Apoptosis in Human Umbilical Vein Endothelial Cells via the Nrf2/HO-1 Signaling Pathway and Improves Skin Flap Survival

Front Pharmacol.

2021 Nov 4;12:735530. doi: 10.3389/fphar.2021.735530.

(IF 4.225)

1924. Zhuang Geng, Xiang Wang, Shiyuan Hao, Bingzi Dong, Yajing Huang, Yangang Wang, Lili Xu

.

LncRNA NNT-AS1 regulates proliferation, ECM accumulation and inflammation of human mesangial cells induced by high glucose through miR-214-5p/smad4

BMC Nephrol.

2021 Nov 6;22(1):368. doi: 10.1186/s12882-021-02580-y.

(IF 1.913)

1925. Ning Cui, Yong Liang, Junyu Wang, Bo Liu, Bing Wei, Yu Zhao

.

Minocycline attenuates oxidative and inflammatory injury in a intestinal perforation induced septic lung injury model via down-regulating lncRNA MALAT1 expression

Int Immunopharmacol.

2021 Nov;100:108115. doi: 10.1016/j.intimp.2021.108115.

(IF 3.943)

1926. Xi Wu, Muhammad Asim Farooq, Tiantian Li, Tianjiao Geng, Perpeuta Takunda Kutoka, Bo Wang

.

Cationic chitosan-modified silica nanoparticles for oral delivery of protein vaccine

J Biomed Mater Res A.

2021 Nov;109(11):2111-2119. doi: 10.1002/jbm.a.37198.

(IF 3.525)

1927. Abdullrahman M Al-Bishari, Kendrick Hii Ru Yie, Mohammed A Al-Baadani, Bilal A Al-Shaaobi, Zixin Zhou, Kai Fang, Anba Sun, Yiding Shen, Lei Cai, Lili Yao, Xi Ding, Xinkun Shen, Jinsong Liu

.

JK-2 loaded electrospun membrane for promoting bone regeneration

Mater Sci Eng C Mater Biol Appl.

2021 Nov;130:112471. doi: 10.1016/j.msec.2021.112471.

1928. Yu Wang, Chuanyu Gao, Ke Zhou, Weili Liu, Yulin Zhang, Yi Zhao

.

MicroRNA-532-5p-programmed cell death protein 4 (PDCD4) axis regulates angiotensin II-induced human umbilical vein endothelial cell apoptosis and proliferation

Microvasc Res.

2021 Nov;138:104195. doi: 10.1016/j.mvr.2021.104195.

(IF 2.73)

1929. Wei Gao, Ya Ning, Yujie Peng, Xintong Tang, Siyu Zhong, Hongyan Zeng

.

LncRNA NKILA relieves astrocyte inflammation and neuronal oxidative stress after cerebral ischemia/reperfusion by inhibiting the NF-κB pathway

Mol Immunol.

2021 Nov;139:32-41. doi: 10.1016/j.molimm.2021.08.002.

(IF 3.641)

1930. Xianfeng Chen, Juanjuan Huang

.

Mangiferin inhibits hypoxia/reoxygenation-induced alveolar epithelial cell injury via the SIRT1/AMPK signaling pathway

Exp Ther Med.

2021 Nov;22(5):1220. doi: 10.3892/etm.2021.10654.

(IF 1.785)

1931. Ling Han, Chaopan Zheng, Shihai Wu

.

Long non-coding RNA NEAT1 promotes the malignancy of laryngeal squamous cell carcinoma by regulating the microRNA-204-5p/SEMA4B axis

Oncol Lett.

2021 Nov;22(5):802. doi: 10.3892/ol.2021.13063.

(IF 2.311)

1932. Han Li, Dong Peng, Shi-Jie Zhang, Yang Zhang, Qi Wang, Li Guan

.

Buyang Huanwu Decoction promotes neurogenesis via sirtuin 1/autophagy pathway in a cerebral ischemia model

Mol Med Rep.

2021 Nov;24(5):791. doi: 10.3892/mmr.2021.12431.

(IF 2.1)

1933. Yujing Huang, Ying Liu, Jing Huang, Lu Gao, Zhenggang Wu, Lu Wang, Lin Fan

.

Let‑7b‑5p promotes cell apoptosis in Parkinson's disease by targeting HMGA2

Mol Med Rep.

2021 Nov;24(5):820. doi: 10.3892/mmr.2021.12461.

(IF 2.1)

1934. Zhihui Guan, Lingmin Zhou, Yu Zhang, Yu Zhang, Hongping Chen, Feifei Shao

.

Sulforaphane Ameliorates the Liver Injury of Traumatic Hemorrhagic Shock Rats

J Surg Res.

2021 Nov;267:293-301. doi: 10.1016/j.jss.2021.05.004.

(IF 1.841)

1935. Haijun Ran, Han Liu, Ping Wu

.

Echinatin mitigates H2O2-induced oxidative damage and apoptosis in lens epithelial cells via the Nrf2/HO-1 pathway

Adv Clin Exp Med.

2021 Nov;30(11):1195-1203. doi: 10.17219/acem/139130.

(IF 1.514)

1936. Zi-Zhen Zhang, Jiao-Jiao Chen, Wen-Yi Deng, Xiao-Hua Yu, Wei-Hua Tan

.

CTRP1 decreases ABCA1 expression and promotes lipid accumulation through the miR-424-5p/FoxO1 pathway in THP-1 macrophage-derived foam cells

Cell Biol Int.

2021 Nov;45(11):2226-2237. doi: 10.1002/cbin.11666.

(IF 2.571)

1937. Wen Sheng, Wenjing Xu, Jin Ding, Ling Li, Xujun You, Yongrong Wu, Qinghu He

.

Curcumol inhibits the malignant progression of prostate cancer and regulates the PDK1/AKT/mTOR pathway by targeting miR‑9

Oncol Rep.

2021 Nov;46(5):246. doi: 10.3892/or.2021.8197.

(IF 3.417)

1938. Hengshuai Zhang, Jiang Zhao, Qudong Lu, Bishao Sun, Xin Liu, Chengfei Yang, Shuai Li, Longkun Li, Shanhong Yi, Zhenxing Yang, Jie Xu

.

Luteolin Improves Cyclophosphamide-Induced Cystitis through TXNIP/NLRP3 and NF- κ B Pathways

Evid Based Complement Alternat Med.

2021 Nov 11;2021:1718709. doi: 10.1155/2021/1718709.

1939. Junji Zhu, Wuhan Xiao

.

A proteomics protocol to identify stimulation-induced binding partners dependent on a specific gene in mammalian cells

STAR Protoc.

2021 Nov 13;2(4):100962. doi: 10.1016/j.xpro.2021.100962.

1940. Yuexin Wei, Yu Zhou, Chunlan Long, Huan Wu, Yifan Hong, Yan Fu, Junke Wang, Yuhao Wu, Lianju Shen, Guanghui Wei

.

Polystyrene microplastics disrupt the blood-testis barrier integrity through ROS-Mediated imbalance of mTORC1 and mTORC2

Environ Pollut.

2021 Nov 15;289:117904. doi: 10.1016/j.envpol.2021.117904.

(IF 6.792)

1941. Yanjun Chen, Jiayu Wang, Juntao Li, Jinghan Zhu, Ruoqin Wang, Qinhua Xi, Hongya Wu, Tongguo Shi, Weichang Chen

.

Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway

Eur J Pharmacol.

2021 Nov 15;911:174518. doi: 10.1016/j.ejphar.2021.174518.

(IF 3.263)

1942. Yue Wu, Tian Tian, Yin Wu, Yu Yang, Yunfei Zhang, Ximing Qin

.

Systematic Studies of the Circadian Clock Genes Impact on Temperature Compensation and Cell Proliferation Using CRISPR Tools

Biology (Basel).

2021 Nov 18;10(11):1204. doi: 10.3390/biology10111204.

1943. Meiyun Sun, Jinjing Xie, Dongze Zhang, Chunyang Chen, Simin Lin, Yan Chen, Guangbo Zhang

.

B7-H3 inhibits apoptosis of gastric cancer cell by interacting with Fibronectin

J Cancer.

2021 Nov 8;12(24):7518-7526. doi: 10.7150/jca.59263.

(IF 3.565)

1944. Li Wang, Jing Mi, Bingjing Sun, Gang Yang, Shangfen Liu, Meihua Chen, Liming Yu, Jie Pan, Yuehua Liu

.

Role of transient receptor potential channel 6 in the osteogenesis of periodontal ligament cells

Int Immunopharmacol.

2021 Nov;100:108134. doi: 10.1016/j.intimp.2021.108134.

(IF 3.943)

1945. Xiao-Long Li, Pu Wang, Yuan Xie

.

Protease nexin-1 protects against Alzheimer's disease by regulating the sonic hedgehog signaling pathway

Int J Neurosci.

2021 Nov;131(11):1087-1096. doi: 10.1080/00207454.2020.1773821.

(IF 2.107)

1946. Huan Xiao, Qingsong Jiang, Hongmei Qiu, Ke Wu, Xiaojiao Ma, Junxia Yang, Oumei Cheng

.

Gastrodin promotes hippocampal neurogenesis via PDE9-cGMP-PKG pathway in mice following cerebral ischemia

Neurochem Int.

2021 Nov;150:105171. doi: 10.1016/j.neuint.2021.105171.

(IF 3.881)

1947. Zai-Wang Li, Jing-Jing Zhao, Su-Ya Li, Ting-Ting Cao, Yi Wang, Yi Guo, Guang-Jun Xi

.

Blocking the EGFR/p38/NF-κB signaling pathway alleviates disruption of BSCB and subsequent inflammation after spinal cord injury

Neurochem Int.

2021 Nov;150:105190. doi: 10.1016/j.neuint.2021.105190.

(IF 3.881)

1948. Yanan Yang, Yuanrong Liu, Ning Xie, Liying Shao, Hang Sun, Yubo Wei, Yunxiao Sun, Pingyu Wang, Yunfei Yan, Shuyang Xie, Youjie Li

.

Anticancer roles of let-7f-1-3p in non-small cell lung cancer via direct targeting of integrin β1

Exp Ther Med.

2021 Nov;22(5):1305. doi: 10.3892/etm.2021.10740.

(IF 1.785)

1949. Yu Sun, Guangtao Ma, Hongtao Xiang, Xiaomin Wang, Hanmei Wang, Yan Zhang, Fuzhong Qie, Chenlong Li

.

circFLNA promotes glioblastoma proliferation and invasion by negatively regulating miR‑199‑3p expression

Mol Med Rep.

2021 Nov;24(5):786. doi: 10.3892/mmr.2021.12426.

(IF 2.1)

1950. Xiaohong Ni, Yongjiang Feng, Xiangwei Fu

.

Role of salt‑inducible kinase 2 in the malignant behavior and glycolysis of colorectal cancer cells

Mol Med Rep.

2021 Nov;24(5):822. doi: 10.3892/mmr.2021.12460.

(IF 2.1)

1951. Ying Jia, Pengtian Lu, Liu Qi, Jiayao Li, Mengdi Wang, Jiping Qi, Yuejia Song

.

Protective roles of liraglutide against brain injury of streptozotocin induced diabetic rats

Pak J Pharm Sci.

2021 Nov;34(6):2121-2129.

(IF 0.562)

1952. Jian Li, Mingyi Zhao, Xinying Xiang, Qingnan He, Rong Gui

.

A novel biomimetic nanomedicine system with anti-inflammatory and anti-osteoporosis effects improves the therapy efficacy of steroid-resistant nephrotic syndrome

J Nanobiotechnology.

2021 Dec 13;19(1):417. doi: 10.1186/s12951-021-01165-z.

1953. Yuanyuan Tu, Lele Li, Linling Zhu, Yang Guo, Shu Du, Yuxing Zhang, Zhenzhen Wang, Yuting Zhang, Manhui Zhu

.

Geniposide Attenuates Hyperglycemia-Induced Oxidative Stress and Inflammation by Activating the Nrf2 Signaling Pathway in Experimental Diabetic Retinopathy

Oxid Med Cell Longev.

2021 Dec 13;2021:9247947. doi: 10.1155/2021/9247947.

(IF 5.076)

1954. Xiaoting Liao, Weikang Zhang, Huijun Dai, Ren Jing, Mengling Ye, Wanyun Ge, Shenglin Pei, Linghui Pan

.

Neutrophil-Derived IL-17 Promotes Ventilator-Induced Lung Injury via p38 MAPK/MCP-1 Pathway Activation

Front Immunol.

2021 Dec 15;12:768813. doi: 10.3389/fimmu.2021.768813.

(IF 5.085)

1955. Sheng Chang, Yang Cao

.

The ROCK inhibitor Y-27632 ameliorates blood-spinal cord barrier disruption by reducing tight junction protein degradation via the MYPT1-MLC2 pathway after spinal cord injury in rats

Brain Res.

2021 Dec 15;1773:147684. doi: 10.1016/j.brainres.2021.147684.

(IF 2.733)

1956. Yue Wang, Rong Jin, Jiebiao Chen, Jinping Cao, Jianbo Xiao, Xian Li, Chongde Sun

.

Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination

Food Chem.

2021 Dec 15;365:130470. doi: 10.1016/j.foodchem.2021.130470.

(IF 6.306)

1957. Deqiang Kong, Yuancong Jiang, Xiaolong Miao, Zelai Wu, Han Liu, Weihua Gong

.

Tadalafil enhances the therapeutic efficacy of BET inhibitors in hepatocellular carcinoma through activating Hippo pathway

Biochim Biophys Acta Mol Basis Dis.

2021 Dec 1;1867(12):166267. doi: 10.1016/j.bbadis.2021.166267.

1958. Zhiqiang He, Shun Lei, Fucheng Liang, Liuchang Tan, Weinan Zhang, Luoyingzi Xie, Hong Zheng, Yuangang Lu

.

Low-Dose Albendazole Inhibits Epithelial-Mesenchymal Transition of Melanoma Cells by Enhancing Phosphorylated GSK-3 β/Tyr216 Accumulation

J Oncol.

2021 Dec 20;2021:4475192. doi: 10.1155/2021/4475192.

(IF 2.206)

1959. Xin Huang, Jibin Guan, Zitong Sheng, Menghua Wang, Tianhua Xu, Guangying Guo, Pengzhi Wan, Binyao Tian, Junlei Zhou, Aoran Huang, Junfeng Hao, Li Yao

.

Effect of local anti-vascular endothelial growth factor therapy to prevent the formation of stenosis in outflow vein in arteriovenous fistula

J Transl Int Med.

2021 Dec 31;9(4):307-317. doi: 10.2478/jtim-2021-0045.

1960. Weilin Wang, Yan Li, Siqi Fan, Xingye Lian, Wanqing Cao, Xiaorui Song, Qilin Yi, Lingling Wang, Linsheng Song

.

The Elevated Expressions of Anti-lipopolysaccharide Factors After Priming Stimulation Confer Lastingly Humoral Protection in Crab Eriocheir sinensis

Front Immunol.

2021 Dec 8;12:757434. doi: 10.3389/fimmu.2021.757434.

(IF 5.085)

1961. He-Tao Bian, Ling Xiao, Liang Liang, Yin-Ping Xie, Hui-Ling Wang, Gao-Hua Wang

.

RGFP966 is protective against lipopolysaccharide-induced depressive-like behaviors in mice by inhibiting neuroinflammation and microglial activation

Int Immunopharmacol.

2021 Dec;101(Pt B):108259. doi: 10.1016/j.intimp.2021.108259.

(IF 3.943)

1962. Yang Yang, Fenglong Zhao, Zhe Yuan, Chuanqiang Wang, Ke Chen, Wenliang Xiao

.

Inhibition of miR-218-5p reduces myocardial ischemia-reperfusion injury in a Sprague-Dawley rat model by reducing oxidative stress and inflammation through MEF2C/NF-κB pathway

Int Immunopharmacol.

2021 Dec;101(Pt B):108299. doi: 10.1016/j.intimp.2021.108299.

(IF 3.943)

1963. Abdoulaye Issotina Zibrila, Yubei Li, Zheng Wang, Gongxiao Zhao, Haotian Liu, Jing Leng, Md Ahasan Ali, James Ampofo Osei, Yu-Ming Kang, Jinjun Liu

.

Acetylcholinesterase inhibition with Pyridostigmine attenuates hypertension and neuroinflammation in the paraventricular nucleus in rat model for Preeclampsia

Int Immunopharmacol.

2021 Dec;101(Pt B):108365. doi: 10.1016/j.intimp.2021.108365.

(IF 3.943)

1964. Chengwu Tang, Wenming Feng, Ying Bao, Huimin Du

.

Long non-coding RNA TINCR promotes hepatocellular carcinoma proliferation and invasion via STAT3 signaling by direct interacting with T-cell protein tyrosine phosphatase (TCPTP)

Bioengineered.

2021 Dec;12(1):2119-2131. doi: 10.1080/21655979.2021.1930336.

(IF 2.205)

1965. Xinyu Tang, YiHe Wu, Jie Yang, Wenyu Zhu

.

Regulating COX10-AS1 / miR-142-5p / PAICS axis inhibits the proliferation of non-small cell lung cancer

Bioengineered.

2021 Dec;12(1):4643-4653. doi: 10.1080/21655979.2021.1957072.

(IF 2.205)

1966. Pan Liu, Zhengdong Zhang, Jinwu Wang, Xiao Zhang, Xiaoping Yu, Yao Li

.

Empagliflozin protects diabetic pancreatic tissue from damage by inhibiting the activation of the NLRP3/caspase-1/GSDMD pathway in pancreatic β cells: in vitro and in vivo studies

Bioengineered.

2021 Dec;12(2):9356-9366. doi: 10.1080/21655979.2021.2001240.

(IF 2.205)

1967. Weihong Xu, Lu Ye, Huaxiang Wu

.

MicroRNA-4423-3p inhibits proliferation of fibroblast-like synoviocytes by targeting matrix metalloproteinase 13 in rheumatoid arthritis

Bioengineered.

2021 Dec;12(2):9411-9423. doi: 10.1080/21655979.2021.1988372.

(IF 2.205)

1968. Boyi Niu, Kaixin Liao, Yixian Zhou, Ting Wen, Guilan Quan, Chuanbin Wu, Xin Pan

.

Cellular defense system-destroying nanoparticles as a platform for enhanced chemotherapy against drug-resistant cancer

Mater Sci Eng C Mater Biol Appl.

2021 Dec;131:112494. doi: 10.1016/j.msec.2021.112494.

1969. Ying Jiang, Fengying Huang, Xiaoshan Chai, Wen Yuan, Hui Ding, Xianqing Wu

.

The role of IP-10 and its receptor CXCR3 in early pregnancy

Mol Immunol.

2021 Dec;140:59-69. doi: 10.1016/j.molimm.2021.09.013.

(IF 3.641)

1970. Yunxing Fu, Zhen Yang, Hongjuan Zhang, Yu Liu, Baocheng Hao, Ruofeng Shang

.

14-O-[(4,6-Diamino-pyrimidine-2-yl) thioacetyl] mutilin inhibits α-hemolysin and protects Raw264.7 cells from injury induced by methicillin-resistant S. aureus

Microb Pathog.

2021 Dec;161(Pt A):105229. doi: 10.1016/j.micpath.2021.105229.

1971. Jianlong Zhao, Qinghua Sun, Michaël Quentin, Jian Ling, Pierre Abad, Xiaoping Zhang, Yan Li, Yuhong Yang, Bruno Favery, Zhenchuan Mao, Bingyan Xie

.

A Meloidogyne incognita C-type lectin effector targets plant catalases to promote parasitism

New Phytol.

2021 Dec;232(5):2124-2137. doi: 10.1111/nph.17690.

(IF 8.512)

1972. Gangling Chen, Jiangwei Zhang, Mingyue Sheng, Sanli Zhang, Qi Wu, Lei Liu, Boyang Yu, Junping Kou

.

Serum of limb remote ischemic postconditioning inhibits fMLP-triggered activation and reactive oxygen species releasing of rat neutrophils

Redox Rep.

2021 Dec;26(1):176-183. doi: 10.1080/13510002.2021.1982515.

(IF 2.753)

1973. Xueyi Chen, Pengyun She, Caihua Wang, Lina Shi, Tieying Zhang, Yanfei Wang, Haixia Li, Lu Qian, Man Li

.

Hsa_circ_0001806 promotes glycolysis and cell progression in hepatocellular carcinoma through miR-125b/HK2

J Clin Lab Anal.

2021 Dec;35(12):e23991. doi: 10.1002/jcla.23991.

(IF 1.54)

1974. Gaofeng Zhang, Hai Wang, Qianxi Zhang, Zhengyu Zhao, Wenyang Zhu, Xiaohua Zuo

.

Bergenin alleviates H2 O2 -induced oxidative stress and apoptosis in nucleus pulposus cells: Involvement of the PPAR-γ/NF-κB pathway

Environ Toxicol.

2021 Dec;36(12):2541-2550. doi: 10.1002/tox.23368.

(IF 3.118)

1975. Hongtao Wang, Wei Jiang, Yanchao Hu, Zhaofei Wan, Hongyuan Bai, Qiang Yang, Qiangsun Zheng

.

Quercetin improves atrial fibrillation through inhibiting TGF-β/Smads pathway via promoting MiR-135b expression

Phytomedicine.

2021 Dec;93:153774. doi: 10.1016/j.phymed.2021.153774.

(IF 4.268)

1976. Qiao En, Huang Zeping, Wang Yuetang, Wang Xu, Wang Wei

.

Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way

Mol Med.

2021 Dec 11;27(1):156. doi: 10.1186/s10020-021-00416-x.

(IF 4.096)

1977. Dongming Wu, Xiaopeng Wang, Ye Han, Yayun Wang

.

The effect of lipocalin-2 (LCN2) on apoptosis: a proteomics analysis study in an LCN2 deficient mouse model

BMC Genomics.

2021 Dec 13;22(1):892. doi: 10.1186/s12864-021-08211-y.

(IF 3.594)

1978. Lu Gan, Haoze Shi, Ying Zhang, Jianfang Sun, Hao Chen

.

Proteomic Screening and Verification of Biomarkers in Different Stages of Mycosis Fungoides: A pilot Study

Front Cell Dev Biol.

2021 Dec 13;9:747017. doi: 10.3389/fcell.2021.747017.

(IF 5.201)

1979. Mohan Li, Haikun Yu, Jiali Chen, Rayhnigul Abdlla, Aicheng Liu, Wanying Song, Juan Zhang, Xiumin Zhang, Xiqing Yue, Qilong Li

.

Novel insights into whey protein differences between donkey and bovine milk

Food Chem.

2021 Dec 15;365:130397. doi: 10.1016/j.foodchem.2021.130397.

(IF 6.306)

1980. Yuhan Shu, Xin Sun, Guiqin Ye, Mengting Xu, Zhipan Wu, Caixia Wu, Shouxin Li, Jingkui Tian, Haote Han, Jianbin Zhang

.

DHOK Exerts Anti-Cancer Effect Through Autophagy Inhibition in Colorectal Cancer

Front Cell Dev Biol.

2021 Dec 17;9:760022. doi: 10.3389/fcell.2021.760022.

(IF 5.201)

1981. Tianle Gu, Dandan Yu, Ling Xu, Yu-Lin Yao, Yong-Gang Yao

.

Tupaia GBP1 Interacts with STING to Initiate Autophagy and Restrict Herpes Simplex Virus Type 1 Infection

J Immunol.

2021 Dec 1;207(11):2673-2680. doi: 10.4049/jimmunol.2100325.

(IF 4.886)

1982. Xi Su, Wenqiang Li, Zhen Li, Kang Liu, Meng Song, Minglong Shao, Luxian Lv, Xulu Chang

.

Chronic developmental exposure to low-dose ([C8mim][PF6]) induces neurotoxicity and behavioural abnormalities in rats

Ecotoxicol Environ Saf.

2021 Dec 1;225:112806. doi: 10.1016/j.ecoenv.2021.112806.

1983. Chipeng Xiao, Chen Lv, Siyuan Sun, Heping Zhao, Hanzhi Ling, Man Li, Yang Qin, Jinhao Zhang, Jianguang Wang, Xinyu Yang

.

TSP1 is the essential domain of SEMA5A involved in pannus formation in rheumatoid arthritis

Rheumatology (Oxford).

2021 Dec 1;60(12):5833-5842. doi: 10.1093/rheumatology/keab133.

1984. Peng Li, Li-Yan Yao, Yu-Jia Jiang, Dan-Dan Wang, Ting Wang, Yan-Ping Wu, Bai-Xiang Li, Xue-Ting Li

.

Soybean isoflavones protect SH-SY5Y neurons from atrazine-induced toxicity by activating mitophagy through stimulation of the BEX2/BNIP3/NIX pathway

Ecotoxicol Environ Saf.

2021 Dec 20;227:112886. doi: 10.1016/j.ecoenv.2021.112886.

1985. Sizhen Wang, Jie Li, Zhiqiang Ma, Linhong Sun, Lei Hou, Ying Huang, Yunchang Zhang, Beibei Guo, Feng Yang

.

A Sequential Therapeutic Hydrogel With Injectability and Antibacterial Activity for Deep Burn Wounds' Cleaning and Healing

Front Bioeng Biotechnol.

2021 Dec 2;9:794769. doi: 10.3389/fbioe.2021.794769.

1986. Qijiang Xiong, Hai Su

.

MiR-325-3p functions as a suppressor miRNA and inhibits the proliferation and metastasis of glioma through targeting FOXM1

J Integr Neurosci.

2021 Dec 30;20(4):1019-1028. doi: 10.31083/j.jin2004103.

(IF 1.193)

1987. Quancheng Liu, Fuchang Li, Libo Huang, Wenjie Chen, Zhongyuan Li, Chunyang Wang

.

FumDSB Can Reduce the Toxic Effects of Fumonisin B1 by Regulating Several Brain-Gut Peptides in Both the Hypothalamus and Jejunum of Growing Pigs

Toxins (Basel).

2021 Dec 7;13(12):874. doi: 10.3390/toxins13120874.

1988. Yao Qian, Hao Chen, Tianyun Pan, Tian Li, Zikai Zhang, Xuling Lv, Jingping Wang, Ziwan Ji, Yucang He, Liqun Li, Ming Lin

.

Autologous decellularized extracellular matrix promotes adipogenic differentiation of adipose derived stem cells in low serum culture system by regulating the ERK1/2-PPARγ pathway

Adipocyte.

2021 Dec;10(1):174-188. doi: 10.1080/21623945.2021.1906509.

(IF 3.146)

1989. Erpeng Zhu, Huawei Wu, Wenxian Chen, Yuwei Qin, Jiameng Liu, Shuangqi Fan, Shengming Ma, Keke Wu, Qian Mao, Chaowei Luo, Yixian Qin, Lin Yi, Hongxing Ding, Mingqiu Zhao, Jinding Chen

.

Classical swine fever virus employs the PERK- and IRE1-dependent autophagy for viral replication in cultured cells

Virulence.

2021 Dec;12(1):130-149. doi: 10.1080/21505594.2020.1845040.

(IF 5.542)

1990. Jing Chen, Yi Zhou, Erpeng Zhu, Peng Yang, Mei Li, Shuangxiang Zhang, Jun Yue, Ming Wen, Kaigong Wang, Zhentao Cheng

.

Mycoplasma ovipneumoniae induces caspase-8-dependent extrinsic apoptosis and p53- and ROS-dependent intrinsic apoptosis in murine alveolar macrophages

Virulence.

2021 Dec;12(1):2703-2720. doi: 10.1080/21505594.2021.1984714.

(IF 5.542)

1991. Ji Wu, Yang Fu, Ying-Xing Wu, Zu-Xiang Wu, Zhen-Hua Wang, Ping Li

.

Lycorine ameliorates isoproterenol-induced cardiac dysfunction mainly via inhibiting inflammation, fibrosis, oxidative stress and apoptosis

Bioengineered.

2021 Dec;12(1):5583-5594. doi: 10.1080/21655979.2021.1967019.

(IF 2.205)

1992. Huina Wang, Xiuli Yi, Sen Guo, Sijia Wang, Jinyuan Ma, Tao Zhao, Qiong Shi, Yangzi Tian, Hao Wang, Lintao Jia, Tianwen Gao, Chunying Li, Weinan Guo

.

The XBP1‒MARCH5‒MFN2 Axis Confers Endoplasmic Reticulum Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma

J Invest Dermatol.

2021 Dec;141(12):2932-2943.e12. doi: 10.1016/j.jid.2021.03.031.

(IF 7.143)

1993. Gaoying Ran, Wei Fang, Lifang Zhang, Yuting Peng, Anbiao Wu, Jiatong Li, Xianglong Ding, Shuguang Zeng, Yan He

.

Polypeptides IGF-1C and P24 synergistically promote osteogenic differentiation of bone marrow mesenchymal stem cells in vitro through the p38 and JNK signaling pathways

Int J Biochem Cell Biol.

2021 Dec;141:106091. doi: 10.1016/j.biocel.2021.106091.

1994. Yizhong Peng, Hui Lin, Shuo Tian, Sheng Liu, Jinye Li, Xiao Lv, Songfeng Chen, Lei Zhao, Feifei Pu, Xi Chen, Hongyang Shu, Xiangcheng Qing, Zengwu Shao

.

Glucagon-like peptide-1 receptor activation maintains extracellular matrix integrity by inhibiting the activity of mitogen-activated protein kinases and activator protein-1

Free Radic Biol Med.

2021 Dec;177:247-259. doi: 10.1016/j.freeradbiomed.2021.10.034.

1995. Jing-Yang Gu, Yao-Wei Xu, Lai-Peng Feng, Jiao Dong, Li-Qin Zhao, Cong Liu, Hui-Ying Wang, Xiang-Yang Zhang, Cai Song, Chang-Hong Wang

.

Enriched environment mitigates depressive behavior by changing the inflammatory activation phenotype of microglia in the hippocampus of depression model rats

Brain Res Bull.

2021 Dec;177:252-262. doi: 10.1016/j.brainresbull.2021.10.005.

(IF 3.37)

1996. Dan Yi, Dongxin Zhang, Jie He

.

Long non-coding RNA LIFR-AS1 suppressed the proliferation, angiogenesis, migration and invasion of papillary thyroid cancer cells via the miR-31-5p/SIDT2 axis

Cell Cycle.

2021 Dec;20(24):2619-2637. doi: 10.1080/15384101.2021.1995129.

(IF 3.699)

1997. Shujuan Yao, Wen Wang, Bin Zhou, Xiujuan Cui, Hui Yang, Shiqian Zhang

.

Monensin suppresses cell proliferation and invasion in ovarian cancer by enhancing MEK1 SUMOylation

Exp Ther Med.

2021 Dec;22(6):1390. doi: 10.3892/etm.2021.10826.

(IF 1.785)

1998. Yanning Li, Zhibin Dong, Gehua Wen, Xinghua Ren, Weishu Ren, Lei Yan, Xiaolong Wang, Hao Yu, Xue Wu, Xi Xia, Yan Lu, Xu Wu

.

Long-term ketamine administration induces bladder damage and upregulates autophagy-associated proteins in bladder smooth muscle tissue

Environ Toxicol.

2021 Dec;36(12):2521-2529. doi: 10.1002/tox.23365.

(IF 3.118)

1999. Wangchao Dong, Shanshan Wang, Weiqing Qian, Suming Li, Peimin Wang

.

Cedrol alleviates the apoptosis and inflammatory response of IL-1β-treated chondrocytes by promoting miR-542-5p expression

In Vitro Cell Dev Biol Anim.

2021 Dec;57(10):962-972. doi: 10.1007/s11626-021-00620-3.

2000. Yao Qian, Xiaofang Yu, Tianyun Pan, Tian Li, Zikai Zhang, Xuling Lv, Hao Chen, Yucang He, Liqun Li, Ming Lin

.

Substrate coated with autologous decellularized extracellular matrix facilitates in vitro spreading of spheroid from adipose-derived stem cells through regulating ERK1/2-MMP2/9 pathway

Cytotechnology.

2021 Dec;73(6):787-800. doi: 10.1007/s10616-021-00497-w.

(IF 1.777)

2001. Huanhuan Zhu, Shaopeng Tong, Yan Cui, Xiaodong Wang, Minying Wang

.

Tanshinol alleviates ulcerative colitis by promoting the expression of VLDLR

Drug Dev Res.

2021 Dec;82(8):1258-1268. doi: 10.1002/ddr.21840.

2002. Hui Zou, Ling Wang, Jianya Zhao, Yan Yuan, Tao Wang, Jianchun Bian, Zongping Liu

.

MiR-155 promotes cadmium-induced autophagy in rat hepatocytes by suppressing Rheb expression

Ecotoxicol Environ Saf.

2021 Dec 20;227:112895. doi: 10.1016/j.ecoenv.2021.112895.

2003. Siyi Wu, Zhao Li, Mengling Ye, Chunxia Liu, Hao Liu, Xiaojing He, Yi Qin, Fangte Liang, Linghui Pan, Fei Lin

.

VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction

Biomed Res Int.

2021 Dec 22;2021:4525988. doi: 10.1155/2021/4525988.

(IF 2.276)

2004. Yun-Sen Zhu, Jiang-Nan Zhang, Ting-Ting Mo, Chang Jiang, Ru-Chao Ma, Liang Chen

.

Discoidin domain receptor 2 activation of p38 mitogen-activated protein kinase as an important pathway for osteonectin-regulating osteoblast mineralization

J Orthop Surg Res.

2021 Dec 7;16(1):711. doi: 10.1186/s13018-021-02860-1.

(IF 1.777)

2005. Xiaochen Wang, Yaochuan Mi, Wei He, Xiaona Hu, Shuo Yang, Lu Zhao, Yanyang Zhang, Binhong Wen

.

Down-regulation of miR-340-5p promoted osteogenic differentiation through regulation of runt-related transcription factor-2 (RUNX2) in MC3T3-E1 cells

Bioengineered.

2021 Dec;12(1):1126-1137. doi: 10.1080/21655979.2021.1905259.

(IF 2.205)

2006. Xinyue Zhou, Zhenyu Chen, Lipeng Pei, Jingli Sun

.

MicroRNA miR-106a-5p targets forkhead box transcription factor FOXC1 to suppress the cell proliferation, migration, and invasion of ectopic endometrial stromal cells via the PI3K/Akt/mTOR signaling pa

Bioengineered.

2021 Dec;12(1):2203-2213. doi: 10.1080/21655979.2021.1933679.

(IF 2.205)

2007. Jia Gu, Sunil Rauniyar, Yan Wang, Wenjian Zhan, Chengkun Ye, Shaogan Ji, Guanzheng Liu

.

Chrysophanol Induced Glioma Cells Apoptosis via Activation of Mitochondrial Apoptosis Pathway

Bioengineered.

2021 Dec;12(1):6855-6868. doi: 10.1080/21655979.2021.1972079.

(IF 2.205)

2008. Jie Zhou, Hao Wu, Cheng Guo, Bing Li, Li-Li Zhou, Ai-Bin Liang, Jian-Fei Fu

.

A comprehensive genome-wide analysis of long non-coding RNA and mRNA expression profiles of JAK2V617F-positive classical myeloproliferative neoplasms

Bioengineered.

2021 Dec;12(2):10564-10586. doi: 10.1080/21655979.2021.2000226.

(IF 2.205)

2009. Yawen Chen, Dan Xu, Xuan Xia, Guanghui Chen, Hao Xiao, Liaobin Chen, Hui Wang

.

Sex difference in adrenal developmental toxicity induced by dexamethasone and its intrauterine programming mechanism

Pharmacol Res.

2021 Dec;174:105942. doi: 10.1016/j.phrs.2021.105942.

(IF 5.893)

2010. Wancheng Liu, Meiling Gao, Lili Li, Yu Chen, Huimin Fan, Qiaomei Cai, Yueyue Shi, Chaohu Pan, Junxiao Liu, Lucy S Cheng, Heng Yang, Genhong Cheng

.

Homeoprotein SIX1 compromises antitumor immunity through TGF-β-mediated regulation of collagens

Cell Mol Immunol.

2021 Dec;18(12):2660-2672. doi: 10.1038/s41423-021-00800-x.

(IF 8.484)

2011. Wenjun Zheng, Bing Liu, Enyi Shi

.

Perillaldehyde Alleviates Spinal Cord Ischemia-Reperfusion Injury Via Activating the Nrf2 Pathway

J Surg Res.

2021 Dec;268:308-317. doi: 10.1016/j.jss.2021.06.055.

(IF 1.841)

2012. Zhuang Liu, Shuai Huang, Man Xu, Wenxue Zhang, Tuchen Guan, Qinghua Wang, Mei Liu, Jian Yao, Yan Liu

.

The vascularization, innervation and myogenesis of early regenerated tail in Gekko japonicus

J Mol Histol.

2021 Dec;52(6):1189-1204. doi: 10.1007/s10735-021-10032-y.

(IF 2.531)

2013. Xu Li, Xin Zhang, Yajun Liu, Ruihan Pan, Xiaolong Liang, Lifa Huang, Chao Yang

.

Exosomes derived from mesenchyml stem cells ameliorate oxygen-glucose deprivation/reoxygenation-induced neuronal injury via transferring MicroRNA-194 and targeting Bach1

Tissue Cell.

2021 Dec;73:101651. doi: 10.1016/j.tice.2021.101651.

(IF 1.837)

2014. Mingfang Huang, Xuqiang Liao, Liang Li, Gao Li, Minbiao Chen

.

MiR-552-3p facilitated cell proliferation, migration and invasion by sponging Fibulin 5 in non-small cell lung cancer via activation of ERK/GSK3β/β-catenin signaling pathway

Tissue Cell.

2021 Dec;73:101672. doi: 10.1016/j.tice.2021.101672.

(IF 1.837)

2015. Meixia Feng, Juan Lv, Chenxi Zhang, Dagui Chen, Huan Guo, Ye Tu, Li Su, Zhibin Wang

.

Astragaloside IV Protects Sepsis-induced Acute Kidney Injury by Attenuating Mitochondrial Dysfunction and Apoptosis in Renal Tubular Epithelial Cells

Curr Pharm Des.

2022;28(34):2825-2834. doi: 10.2174/1381612828666220902123755.

2016. Ying Wang, Yu Wang, Yao Chen, Qianqian Gao, Lihui Hou, Xiaoling Feng

.

HDAC5 inhibits ovarian angiogenesis in dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome

Folia Histochem Cytobiol.

2022;60(3):260-270. doi: 10.5603/FHC.a2022.0024.

2017. Q Y Chen, Y Yin, L Li, Y J Zhang, W He, Y Shi

.

Geniposidic Acid Confers Neuroprotective Effects in a Mouse Model of Alzheimer's Disease through Activation of a PI3K/AKT/GAP43 Regulatory Axis

J Prev Alzheimers Dis.

2022;9(1):158-171. doi: 10.14283/jpad.2021.60.

2018. Qian Guo, Qinfeng Cai, Fang Huang, Zhen Wei, Jian-Zhi Wang, Bin Zhang, Rong Liu, Yang Yang, Xiaochuan Wang, Hong-Lian Li

.

The Therapeutic Effects of Seven Lycopodium Compounds on Cell Models of Alzheimer's Disease

J Alzheimers Dis.

2022;90(2):795-809. doi: 10.3233/JAD-220704.

(IF 3.909)

2019. Zhengru Liu, Mingming Qi, Shan Tian, Qian Yang, Jian Liu, Siwei Wang, Mengyao Ji, Rong Yu, Suqi Zeng, Jinting Li, Yuping Wei, Weiguo Dong

.

Ubiquitin-Specific Protease 25 Aggravates Acute Pancreatitis and Acute Pancreatitis-Related Multiple Organ Injury by Destroying Tight Junctions Through Activation of The STAT3 Pathway

Front Cell Dev Biol.

2022 Jan 13;9:806850. doi: 10.3389/fcell.2021.806850.

(IF 5.201)

2020. Xuguang Zhang, Yuxin Zhang, Mingyan Zhou, Yiqiang Xie, Xiujuan Dong, Feihu Bai, Junqing Zhang

.

DPHC From Alpinia officinarum Ameliorates Oxidative Stress and Insulin Resistance via Activation of Nrf2/ARE Pathway in db/db Mice and High Glucose-Treated HepG2 Cells

Front Pharmacol.

2022 Jan 17;12:792977. doi: 10.3389/fphar.2021.792977.

(IF 4.225)

2021. Meng-Yi Chi, Hong Zhang, Ya-Xian Wang, Xi-Peng Sun, Quan-Jun Yang, Cheng Guo

.

Silibinin Alleviates Muscle Atrophy Caused by Oxidative Stress Induced by Cisplatin through ERK/FoxO and JNK/FoxO Pathways

Oxid Med Cell Longev.

2022 Jan 20:2022:5694223. doi: 10.1155/2022/5694223.

(IF 5.076)

2022. Wen-Jun Liu, Peng-Yu Pan, Ye Sun, Jian-Bo Wang, Huan Zhou, Xin Xie, Zhi-Yuan Duan, Han-Yu Dong, Wen-Na Chen, Li-de Zhang, Chun Wang

.

Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death

Front Oncol.

2022 Jan 20;11:794735. doi: 10.3389/fonc.2021.794735.

(IF 4.848)

2023. Mingyue Hou, Wenfang Bao, Yuanyuan Gao, Jiayue Chen, Guijun Song

.

Honokiol improves cognitive impairment in APP/PS1 mice through activating mitophagy and mitochondrial unfolded protein response

Chem Biol Interact.

2022 Jan 5:351:109741. doi: 10.1016/j.cbi.2021.109741.

2024. Huan Wang, Qi Cheng, Kaikai Chang, Lingjie Bao, Xiaofang Yi

.

Integrated Analysis of Ferroptosis-Related Biomarker Signatures to Improve the Diagnosis and Prognosis Prediction of Ovarian Cancer

Front Cell Dev Biol.

2022 Jan 5;9:807862. doi: 10.3389/fcell.2021.807862.

(IF 5.201)

2025. Mengmeng Ren, Ruilong Li, Bin Han, Yilin You, Weidong Huang, Gang Du, Jicheng Zhan

.

Involvement of the High-Osmolarity Glycerol Pathway of Saccharomyces Cerevisiae in Protection against Copper Toxicity

Antioxidants (Basel).

2022 Jan 21;11(2):200. doi: 10.3390/antiox11020200.

2026. Xin Gong, Mengyi Huang, Lei Chen

.

Mechanism of miR-132-3p Promoting Neuroinflammation and Dopaminergic Neurodegeneration in Parkinson's Disease

eNeuro.

2022 Jan 25;9(1):ENEURO.0393-21.2021. doi: 10.1523/ENEURO.0393-21.2021.

2027. Xiaoting Xi, Jia Ma, Qianbo Chen, Xuewei Wang, Yuan Xia, Xuewei Wen, Jin Yuan, Yan Li

.

Acteoside attenuates hydrogen peroxide-induced injury of retinal ganglion cells via the CASC2/miR-155/mTOR axis

Ann Transl Med.

2022 Jan;10(1):5. doi: 10.21037/atm-21-5630.

(IF 3.297)

2028. Jiaxin Pan, Lu Zhao, Jue Liu, Guoyun Wang

.

Inhibition of circular RNA circ_0138959 alleviates pyroptosis of human gingival fibroblasts via the microRNA-527/caspase-5 axis

Bioengineered.

2022 Jan;13(1):1908-1920. doi: 10.1080/21655979.2021.2020396.

(IF 2.205)

2029. Juan Gong, Luqun Dou, Yang Zhou

.

Positive feedback loop of lncRNA SNHG1/miR‑16‑5p/GATA4 in the regulation of hypoxia/reoxygenation‑induced cardiomyocyte injury

Mol Med Rep.

2022 Jan;25(1):28. doi: 10.3892/mmr.2021.12544.

(IF 2.1)

2030. Shuo Liang, Shuohui Dong, Wenwen Liu, Man Wang, Shanshan Tian, Yu Ai, Haibo Wang

.

Accumulated ROS Activates HIF-1α-Induced Glycolysis and Exerts a Protective Effect on Sensory Hair Cells Against Noise-Induced Damage

Front Mol Biosci.

2022 Jan 12;8:806650. doi: 10.3389/fmolb.2021.806650.

(IF 4.188)

2031. Biao Zhang, Yi Xue, Jin Zhao, Huojun Jiang, Jiaoli Zhu, Hao Yin, Yizhen Qiu, Aihao Hu, Lingqi Xu, Yi Song, Xin Wang

.

Shionone Attenuates Sepsis-Induced Acute Kidney Injury by Regulating Macrophage Polarization via the ECM1/STAT5 Pathway

Front Med (Lausanne).

2022 Jan 24;8:796743. doi: 10.3389/fmed.2021.796743.

2032. Xing Jun Jiang, Yan Qing Wu, Rong Ma, Yan Min Chang, Lu Lu Li, Jia Hui Zhu, Gong Ping Liu, Gang Li

.

PINK1 Alleviates Cognitive Impairments via Attenuating Pathological Tau Aggregation in a Mouse Model of Tauopathy

Front Cell Dev Biol.

2022 Jan 4;9:736267. doi: 10.3389/fcell.2021.736267.

(IF 5.201)

2033. Cheng Ma, Huan Liu, Yifan Wei, He Li, Dengshun Miao, Yongxin Ren

.

Exogenous PTH 1-34 Attenuates Impaired Fracture Healing in Endogenous PTH Deficiency Mice via Activating Indian Hedgehog Signaling Pathway and Accelerating Endochondral Ossification

Front Cell Dev Biol.

2022 Jan 5;9:750878. doi: 10.3389/fcell.2021.750878.

(IF 5.201)

2034. Luming Wan, Qi Gao, Yongqiang Deng, Yuehua Ke, Enhao Ma, Huan Yang, Haotian Lin, Huilong Li, Yilong Yang, Jing Gong, Jingfei Li, Yixin Xu, Jing Liu, Jianmin Li, Jialong Liu, Xuemiao Zhang, Linfei Huang, Jiangyue Feng, Yanhong Zhang, Hanqing Huang, Huapeng Wang, Changjun Wang, Qi Chen, Xingyao Huang, Qing Ye, Dongyu Li, Qiulin Yan, Muyi Liu, Meng Wei, Yunhai Mo, Dongrui Li, Ke Tang, Changqing Lin, Fei Zheng, Lei Xu, Gong Cheng, Peihui Wang, Xiaopan Yang, Feixang Wu, Zhiwei Sun, Chengfeng Qin, Congwen Wei, Hui Zhong

.

GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia

Nat Metab.

2022 Jan;4(1):29-43. doi: 10.1038/s42255-021-00508-2.

2035. Mengmeng Zhao, Hang Zhang, Huiyang Sha, Huawei Li, Ruining Wang

.

Molecular cloning and functional analysis of Macaca mulatta STING

Dev Comp Immunol.

2022 Feb:127:104296. doi: 10.1016/j.dci.2021.104296.

(IF 3.192)

2036. Ping An, Xiao-Chun Zhao, Man-Jia Liu, Yu-Qing You, Jing-Ya Li

.

Gender-based differences in neuroprotective effects of hydrogen gas against intracerebral hemorrhage-induced depression

Neurochem Int.

2022 Feb:153:105276. doi: 10.1016/j.neuint.2022.105276.

(IF 3.881)

2037. Zongting Shi, Jun He, Jian He, Yuan Xu

.

Micro-fragmented adipose tissue regulated the biological functions of osteoarthritis synoviocytes by upregulating MiR-92a-3p expression

Tissue Cell.

2022 Feb:74:101716. doi: 10.1016/j.tice.2021.101716.

(IF 1.837)

2038. Heyu Liu, Chengcheng Xu, Meng Bao, Jin Huang, Liping Zou, Xiaorong Fan, Changhong Zhu, Wei Xia

.

Cold-inducible RNA-binding protein regulates cyclin B1 against spermatogenesis arrest caused by heat stress

Andrology.

2022 Feb;10(2):392-403. doi: 10.1111/andr.13115.

(IF 2.86)

2039. Min Chen, Li Peng, Ping Gong, Xiaoli Zheng, Tao Sun, Xiaoqiao Zhang, Jiangtao Huo

.

Baicalein Induces Mitochondrial Autophagy to Prevent Parkinson's Disease in Rats via miR-30b and the SIRT1/AMPK/mTOR Pathway

Front Neurol.

2022 Feb 14;12:646817. doi: 10.3389/fneur.2021.646817.

(IF 2.889)

2040. Yuan Qi, Yan Tang, Lu Yin, Keke Ding, Cuimei Zhao, Wenwen Yan, Yi'an Yao

.

miR-129-5p restores cardiac function in rats with chronic heart failure by targeting the E3 ubiquitin ligase Smurf1 and promoting PTEN expression

Bioengineered.

2022 Feb;13(2):2371-2386. doi: 10.1080/21655979.2021.2024335.

(IF 2.205)

2041. Lin Yu, Lina Tai, Jiayi Gao, Mingjie Sun, Siqi Liu, Tengda Huang, Jingsu Yu, Zhiwang Zhang, Weiwei Miao, Yixing Li, Ziyi Song, Haojie Zhang, Lei Zhou

.

A New lncRNA, lnc-LLMA, Regulates Lipid Metabolism in Pig Hepatocytes

DNA Cell Biol.

2022 Feb;41(2):202-214. doi: 10.1089/dna.2021.0220.

(IF 3.191)

2042. Shiwu Guo, Zhiwen Song, Junsheng He, Gang Yin, Jianguo Zhu, Haifeng Liu, Lei Yang, Xubiao Ji, Xu Xu, Zhiyuan Liu, Jinbo Liu

.

Akt/Aquaporin-4 Signaling Aggravates Neuropathic Pain by Activating Astrocytes after Spinal Nerve Ligation in Rats

Neuroscience.

2022 Feb 1:482:116-131. doi: 10.1016/j.neuroscience.2021.12.015.

(IF 3.056)

2043. Renchang Chen, Shang Gao, Huapeng Guan, Xin Zhang, Yuliang Gao, Youxiang Su, Yun Song, Yuehua Jiang, Nianhu Li

.

Naringin protects human nucleus pulposus cells against TNF- α-induced inflammation, oxidative stress, and loss of cellular homeostasis by enhancing autophagic flux via AMPK/SIRT1 activation

Oxid Med Cell Longev.

2022 Feb 27:2022:7655142. doi: 10.1155/2022/7655142.

(IF 5.076)

2044. Fucun Zhu, Yi Zhong, Huan Ji, Ran Ge, Lu Guo, Haiyang Song, Heming Wu, Pengfei Jiao, Sheng Li, Chenxing Wang, Hongming Du

.

ACE2 and TMPRSS2 in human saliva can adsorb to the oral mucosal epithelium

J Anat.

2022 Feb;240(2):398-409. doi: 10.1111/joa.13560.

(IF 2.013)

2045. Tianyun Pan, Yao Qian, Tian Li, Zikai Zhang, Yucang He, Jingping Wang, Liqun Li, Yun Hu, Ming Lin

.

Acetyl l-carnitine protects adipose-derived stem cells against serum-starvation: regulation on the network composed of reactive oxygen species, autophagy, apoptosis and senescence

Cytotechnology.

2022 Feb;74(1):105-121. doi: 10.1007/s10616-021-00514-y.

(IF 1.777)

2046. Yuhan Chang, Juan Zhang, Xinying Huo, Xinliang Qu, Chunlei Xia, Kaizong Huang, Fuyang Xie, Nuofan Wang, Xiaowei Wei, Qiong Jia

.

Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction

Cell Rep.

2022 Feb 15;38(7):110390. doi: 10.1016/j.celrep.2022.110390.

(IF 8.109)

2047. Wei Guo, Xiao-Guang Yang, Yu-Lin Shi, Hong Wang

.

The effects and mechanism of paeoniflorin in promoting osteogenic differentiation of MC3T3-E1

J Orthop Surg Res.

2022 Feb 14;17(1):90. doi: 10.1186/s13018-022-02965-1.

(IF 1.777)

2048. Qiang Wang, Jingjing Yu, Wenqi Gao, Yuanyuan Sun, Xuxu Liu, Zhenyi Lv, Long Li, Dongbo Xue

.

The lncRNA TCONS_00021785/miR-21-5p/Trim33 axis regulates VMP1-mediated zymophagy, reduces the activation of trypsinogen, and promotes acinar cell recovery

Cell Death Discov.

2022 Feb 15;8(1):65. doi: 10.1038/s41420-022-00862-4.

2049. Wei Zhang, Minmin Wu, Xucan Gao, Chiyu Ma, Huixuan Xu, Liewen Lin, Jingquan He, Wanxia Cai, Yafang Zhong, Donge Tang, Min Tang, Yong Dai

.

Multi-Platform-Based Analysis Characterizes Molecular Alterations of the Nucleus in Human Colorectal Cancer

Front Cell Dev Biol.

2022 Feb 21:10:796703. doi: 10.3389/fcell.2022.796703.

(IF 5.201)

2050. Pian Liu, Wei Zhou, Liu Yang, Chen Zhang

.

E3 ubiquitin ligase RNF180 reduces sensitivity of triple-negative breast cancer cells to Gefitinib by downregulating RAD51

Chem Biol Interact.

2022 Feb 25:354:109798. doi: 10.1016/j.cbi.2022.109798.

2051. Sihong Li, Ruimeng Liu, Shun Xia, Gaoqiang Wei, Muhammad Ishfaq, Yixin Zhang, Xiuying Zhang

.

Protective role of curcumin on aflatoxin B1-induced TLR4/RIPK pathway mediated-necroptosis and inflammation in chicken liver

Ecotoxicol Environ Saf.

2022 Mar 15:233:113319. doi: 10.1016/j.ecoenv.2022.113319.

2052. Shi-Lei Wang, Yu Wang, Lei Wu, Yuan-Yuan Cai, Zi-Chao Wang, Raphael N Alolga, Lian-Wen Qi, Bin Li, Feng-Qing Huang

.

Paired Derivatization Approach with H/D-Labeled Hydroxylamine Reagents for Sensitive and Accurate Analysis of Monosaccharides by Liquid Chromatography Tandem Mass Spectrometry

Anal Chem.

2022 Mar 1;94(8):3590-3599. doi: 10.1021/acs.analchem.1c04924.

(IF 6.785)

2053. Mengdi Zhang, Yao Cheng, Yujie Zhai, Yaru Cui, Wenshen Zhang, Hongwei Sun, Wenyu Xin, Ling Zhou, Xue Gao, Shucui Li, Hongliu Sun

.

Attenuated succinate accumulation relieves neuronal injury induced by hypoxia in neonatal mice

Cell Death Discov.

2022 Mar 28;8(1):138. doi: 10.1038/s41420-022-00940-7.

2054. Liang Yin, Gang Feng, Chun Huang, Weijuan Cai

.

Proteomic Analysis of Serum Lysine Acetylation in Uyghur Patients With T2DM

Front Mol Biosci.

2022 Mar 30:9:787885. doi: 10.3389/fmolb.2022.787885.

(IF 4.188)

2055. Suhang Guo, Yi Peng, Yan Lou, Lijuan Cao, Junqing Liu, Nengming Lin, Sheng Cai, Yu Kang, Su Zeng, Lushan Yu

.

Downregulation of the farnesoid X receptor promotes colorectal tumorigenesis by facilitating enterotoxigenic Bacteroides fragilis colonization

Pharmacol Res.

2022 Mar:177:106101. doi: 10.1016/j.phrs.2022.106101.

(IF 5.893)

2056. Shi Tang, Bao Su, Tao Tao, Weiping Yan, Rongrong Zhang, Xinyue Qin, Jinzhou Feng

.

RGMa regulates CCL5 expression via the BMP receptor in experimental autoimmune encephalomyelitis mice and endothelial cells

Mol Med Rep.

2022 Mar;25(3):85. doi: 10.3892/mmr.2022.12601.

(IF 2.1)

2057. Yueyang Song, Jiameng Song, Meng Wang, Junwei Wang, Bo Ma, Wenlong Zhang

.

Porcine Gasdermin D Is a Substrate of Caspase-1 and an Executioner of Pyroptosis

Front Immunol.

2022 Mar 14:13:828911. doi: 10.3389/fimmu.2022.828911.

(IF 5.085)

2058. Xing Wei, Andrew Chia Hao Chang, Haishuang Chang, Shan Xu, Yilin Xue, Yuanxin Zhang, Ming Lei, Alex Chia Yu Chang, Qingyong Zhang

.

Hypoglycemia-Exacerbated Mitochondrial Connexin 43 Accumulation Aggravates Cardiac Dysfunction in Diabetic Cardiomyopathy

Front Cardiovasc Med.

2022 Mar 16:9:800185. doi: 10.3389/fcvm.2022.800185.

2059. Yingyi Xu, Na Zhang, Cheng Chen, Xinke Xu, Ailing Luo, Yaping Yan, Yanhua Lu, Jianhua Liu, Xinxu Ou, Yonghong Tan, Yufeng Liang, Lihe Chen, Xingrong Song, Xiaoping Liu

.

Sevoflurane Induces Ferroptosis of Glioma Cells Through Activating the ATF4-CHAC1 Pathway

Front Oncol.

2022 Mar 17:12:859621. doi: 10.3389/fonc.2022.859621.

(IF 4.848)

2060. Hanlin Ma, Gonghua Qi, Fang Han, Wei Lu, Jiali Peng, Rongrong Li, Shi Yan, Cunzhong Yuan, Beihua Kong

.

HMGB3 promotes PARP inhibitor resistance through interacting with PARP1 in ovarian cancer

Cell Death Dis.

2022 Mar 24;13(3):263. doi: 10.1038/s41419-022-04670-7.

(IF 6.304)

2061. Zhenyu Yang, Zuoliang Qi, Xiaonan Yang, Qiuni Gao, Yuling Hu, Xihang Yuan

.

Inhibition of RIP3 increased ADSC viability under OGD and modified the competency of adipogenesis, angiogenesis, and inflammation regulation

Biosci Rep.

2022 Mar 31;42(3):BSR20212808. doi: 10.1042/BSR20212808.

2062. Chen Chen, Hongsheng Liang, Ruirui Qin, Xin Li, Liwei Wang, Songlin Du, Zhihao Chen, Xiangxi Meng, Zhonghua Lv, Qing Wang, Jing Meng, Aili Gao

.

Doramectin inhibits glioblastoma cell survival via regulation of autophagy in vitro and in vivo

Int J Oncol.

2022 Mar;60(3):29. doi: 10.3892/ijo.2022.5319.

(IF 3.899)

2063. Liwei Li, Junhong Zhang, Qing Li, Li Qiao, Pengcheng Li, Yi Cui, Shujun Li, Shirui Hao, Tongqian Wu, Lili Liu, Jianmin Yin, Pingsheng Hu, Xiaowei Dou, Shuping Li, Hui Yang

.

Mutational analysis of compound heterozygous mutation p.Q6X/p.H232R in SRD5A2 causing 46,XY disorder of sex development

Ital J Pediatr.

2022 Mar 24;48(1):47. doi: 10.1186/s13052-022-01243-4.

(IF 2.185)

2064. Xiaohui Liu, Yating Sun, Qilu Wei, Wuqiang Jiang, Ming Jiao, Junteng Yan, Run Tian, Pei Yang, Kunzheng Wang, Chunsheng Wang

.

Captopril alleviates glucocorticoid-induced osteonecrosis of the femoral head by mediating the ACE2/ Ang-(1-7)/Mas receptor cascade

Eur J Pharmacol.

2022 Apr 15:921:174871. doi: 10.1016/j.ejphar.2022.174871.

(IF 3.263)

2065. Xin Zhang, Yaping Jiang, Qian Wang, Weishu An, Xiaoyan Zhang, Ming Xu, Yihui Chen

.

Atypical U3 snoRNA Suppresses the Process of Pterygium Through Modulating 18S Ribosomal RNA Synthesis

Invest Ophthalmol Vis Sci.

2022 Apr 1;63(4):17. doi: 10.1167/iovs.63.4.17.

2066. Hui Yao, Wenting Guo, Longlong Suo, Guoliang Li, Yunsheng Wang, Yuanyuan Chen, Yingui Sun, Runtao Ding

.

Preventive effects of the AMPA receptor potentiator LY450108 in an LPS-induced depressive mouse model

Behav Brain Res.

2022 Apr 29:424:113813. doi: 10.1016/j.bbr.2022.113813.

(IF 2.977)

2067. Yan Tan, Junyu Xiang, Zixian Huang, Lin Wang, Yiling Huang

.

Trichosanthin inhibits cell growth and metastasis by promoting pyroptosis in non-small cell lung cancer

J Thorac Dis.

2022 Apr;14(4):1193-1202. doi: 10.21037/jtd-22-282.

(IF 2.046)

2068. Jing Lv, Shibing Zhu, Huiping Chen, Ying Xu, Qingyu Su, Guofen Yu, Wei Ma

.

Paeonol inhibits human lung cancer cell viability and metastasis in vitro via miR-126-5p/ZEB2 axis

Drug Dev Res.

2022 Apr;83(2):432-446. doi: 10.1002/ddr.21873.

2069. Jinhuan Wei, Rui Shang, Jiaqi Wang, Shengze Zhu, JianQiang Yin, Ying Chen, Yayu Zhao, Gang Chen

.

ACE2 overexpressing mesenchymal stem cells alleviates COVID-19 lung injury by inhibiting pyroptosis

iScience.

2022 Apr 15;25(4):104046. doi: 10.1016/j.isci.2022.104046.

2070. Zili Lei, Wanwan Liu, Ya Nie, Yanhong Yang, Guibin Chen, Li Huang, Huijuan Wu, Yuting Lei, Lei Chen, Qing Hu, Hedong Rong, Siping Yu, Qi Song, Fengxue Tong, Jiao Guo

.

EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice

Front Immunol.

2022 Apr 13:13:843378. doi: 10.3389/fimmu.2022.843378.

(IF 5.085)

2071. Jiao Wang, Qiong Huang, Xingbin Hu, Shuyi Zhang, Yu Jiang, Guangyu Yao, Kongzhen Hu, Xin Xu, Bishan Liang, Qijing Wu, Zhenfeng Ma, Yawen Wang, Chunlin Wang, Zhenzhen Wu, Xiaoxiang Rong, Wangjun Liao, Min Shi

.

Disrupting Circadian Rhythm via the PER1-HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer

Cancer Res.

2022 Apr 15;82(8):1503-1517. doi: 10.1158/0008-5472.CAN-21-1820.

(IF 9.727)

2072. Hong Zhang, Jianming Tang, Yu Cao, Tianhu Wang

.

Salvianolic Acid B Suppresses Non-Small-Cell Lung Cancer Metastasis through PKM2-Independent Metabolic Reprogramming

Evid Based Complement Alternat Med.

2022 Apr 23:2022:9302403. doi: 10.1155/2022/9302403.

2073. Chenhaoyi Xu, Huanghuang Huang, Min Zhang, Pei Zhang, Zezhi Li, Xueyuan Liu, Min Fang

.

Methyltransferase-Like 3 Rescues the Amyloid-beta protein-Induced Reduction of Activity-Regulated Cytoskeleton Associated Protein Expression via YTHDF1-Dependent N6-Methyladenosine Modification

Front Aging Neurosci.

2022 Apr 25:14:890134. doi: 10.3389/fnagi.2022.890134.

(IF 4.362)

2074. Xiu-Yuan Lang, Yang Hu, Jin-Peng Bai, Jun Wang, Xiao-Yan Qin, Rongfeng Lan

.

Coeloglossum viride Var. Bracteatum Extract Attenuates MPTP-Induced Neurotoxicity in vivo by Restoring BDNF-TrkB and FGF2-Akt Signaling Axis and Inhibiting RIP1-Driven Inflammation

Front Pharmacol.

2022 Apr 28:13:903235. doi: 10.3389/fphar.2022.903235.

(IF 4.225)

2075. Wentao Liu, Bin Zhang, Dan Zhang, Feng Guo, Kun Ye, Liang Zhu, Xin Jin

.

The RBPJ/DAPK3/UBE3A signaling axis induces PBRM1 degradation to modulate the sensitivity of renal cell carcinoma to CDK4/6 inhibitors

Cell Death Dis.

2022 Apr 2;13(4):295. doi: 10.1038/s41419-022-04760-6.

(IF 6.304)

2076. Yue Zhang, Mengxian Sun, Dongwei Wang, Yaju Hu, Ruonan Wang, Hongtao Diao, Xiaoqi Shao, Yun Li, Xu Li, Mingyang Leng, Lexun Wang, Meiling Yan, Xianglu Rong, Jiao Guo

.

FTZ protects against cardiac hypertrophy and oxidative injury via microRNA-214 / SIRT3 signaling pathway

Biomed Pharmacother.

2022 Apr:148:112696. doi: 10.1016/j.biopha.2022.112696.

(IF 4.545)

2077. Fenying Lu, Weichang Chen, Tingwang Jiang, Cuie Cheng, Bin Wang, Zhiping Lu, Guojin Huang, Jiaming Qiu, Wei Wei, Ming Yang, Xia Huang

.

Expression profile, clinical significance and biological functions of IGF2BP2 in esophageal squamous cell carcinoma

Exp Ther Med.

2022 Apr;23(4):252. doi: 10.3892/etm.2022.11177.

(IF 1.785)

2078. Xiao-Ling Yan, Fu-You Xu, Jing-Jing Ji, Peng Song, Ya-Qin Pei, Mei-Jun He, Zi-Chuang Wang, Shou-Jiang You, Zi-Chun Hua, Jian Cheng, Jia Jia

.

Activation of UCP2 by anethole trithione suppresses neuroinflammation after intracerebral hemorrhage

Acta Pharmacol Sin.

2022 Apr;43(4):811-828. doi: 10.1038/s41401-021-00698-1.

(IF 5.064)

2079. Gui-Feng Su, Ze-Xiu Huang, Deng-Liang Huang, Peng-Xiao Chen, Yao Wang, Yi-Fei Wang

.

Cepharanthine hydrochloride inhibits the Wnt/β‑catenin/Hedgehog signaling axis in liver cancer

Oncol Rep.

2022 Apr;47(4):83. doi: 10.3892/or.2022.8294.

(IF 3.417)

2080. Zhijie Lin, Fenglan Feng, Jiaming Liang, Haikang Zeng, Jin Li

.

lncRNA RP11-10A14.5: a potential prognosis biomarker for LUAD through regulation on proliferation and metastasis

Discov Oncol.

2022 May 16;13(1):32. doi: 10.1007/s12672-022-00493-2.

2081. Jing He, Liang Xie, Li Yu, Lijun Liu, Hong Xu, Tao Wang, Yuyang Gao, Xuedong Wang, You Duan, Hanmin Liu, Li Dai

.

Maternal serum CFHR4 protein as a potential non-invasive marker of ventricular septal defects in offspring: evidence from a comparative proteomics study

Clin Proteomics.

2022 May 19;19(1):17. doi: 10.1186/s12014-022-09356-y.

2082. Mengmeng Zhao, Huiyang Sha, Hang Zhang, Ruining Wang

.

TRIM4-mediated ubiquitination of NSP2 restricts porcine reproductive and respiratory syndrome virus proliferation

BMC Vet Res.

2022 May 30;18(1):208. doi: 10.1186/s12917-022-03309-1.

(IF 1.835)

2083. Guifang Huang, Xiao He, Zesheng Xue, Yiming Long, Jiakuan Liu, Jinming Cai, Pengfei Tang, Bangmin Han, Bing Shen, Ruimin Huang, Jun Yan

.

Rauwolfia vomitoria extract suppresses benign prostatic hyperplasia by inducing autophagic apoptosis through endoplasmic reticulum stress

BMC Complement Med Ther.

2022 May 5;22(1):125. doi: 10.1186/s12906-022-03610-4.

2084. Pengfei Li, Xiangshun Ren, Yuanyuan Zheng, Jinming Sun, Gang Ye

.

Tumor promoting effect of circ_002172 associates with induced immune escape in breast cancer via the miR-296-5p/CXCL12 axis

Int Immunopharmacol.

2022 May:106:108530. doi: 10.1016/j.intimp.2022.108530.

(IF 3.943)

2085. Mei Yang, Yu-Xia Ma, Ying Zhi, Hai-Bin Wang, Li Zhao, Peng-Sheng Wang, Jie-Ting Niu

.

Inhibitors of IFN gene stimulators (STING) improve intestinal ischemia-reperfusion-induced acute lung injury by activating AMPK signaling

Eur J Med Res.

2022 May 31;27(1):79. doi: 10.1186/s40001-022-00703-1.

(IF 1.826)

2086. Peiyu Han, Li Shen, Nan Nan, Renwu Zhou, Tianci Li, Xiaofeng Dai

.

Cold Atmospheric Plasma Boosts Virus Multiplication via EGFR(Tyr1068) Phosphorylation-Mediated Control on Cell Mitophagy

Int J Biol Sci.

2022 May 9;18(8):3405-3420. doi: 10.7150/ijbs.71983.

(IF 4.858)

2087. Hai-Jun He, Xi Xiong, Shuoting Zhou, Xing-Ru Zhang, Xuemiao Zhao, Lingli Chen, Cheng-Long Xie

.

Neuroprotective effects of curcumin via autophagy induction in 6-hydroxydopamine Parkinson's models

Neurochem Int.

2022 May:155:105297. doi: 10.1016/j.neuint.2022.105297.

(IF 3.881)

2088. Xuefeng Chen, Xinyuan Zhang, Yangyang Qian, Enhui Xia, Yu Wang, Qi Zhou

.

Ultrasound-targeted microbubble destruction-mediated miR-144-5p overexpression enhances the anti-tumor effect of paclitaxel on thyroid carcinoma by targeting STON2

Cell Cycle.

2022 May;21(10):1058-1076. doi: 10.1080/15384101.2022.2040778.

(IF 3.699)

2089. Yueying Wu, Hui Meng, Bo Qiao, Ning Li, Qiang Zhang, Wenqing Jia, Haijing Xing, Yuqing Li, Jiali Yuan, Zhongshan Yang

.

Yifei Sanjie Formula Treats Chronic Obstructive Pulmonary Disease by Remodeling Pulmonary Microbiota

Front Med (Lausanne).

2022 Jun 29;9:927607. doi: 10.3389/fmed.2022.927607.

2090. Siyuan Teng, Ge Liu, Liangjun Li, Jun Ou, Yang Yu

.

CUX1 promotes epithelial-mesenchymal transition (EMT) in renal fibrosis of UUO model by targeting MMP7

Biochem Biophys Res Commun.

2022 Jun 11:608:128-134. doi: 10.1016/j.bbrc.2022.03.097.

2091. Heng Cai, Lin-Yan Huang, Rui Hong, Jin-Xiu Song, Xin-Jian Guo, Wei Zhou, Zhao-Li Hu, Wan Wang, Yan-Ling Wang, Jian-Gang Shen, Su-Hua Qi

.

Momordica charantia Exosome-Like Nanoparticles Exert Neuroprotective Effects Against Ischemic Brain Injury via Inhibiting Matrix Metalloproteinase 9 and Activating the AKT/GSK3β Signaling Pathway

Front Pharmacol.

2022 Jun 24:13:908830. doi: 10.3389/fphar.2022.908830.

(IF 4.225)

2092. Chunxiu Zhou, Yi Tan, Baojun Xu, Yitao Wang, Wai-San Cheang

.

3,4',5-Trimethoxy- trans-stilbene Alleviates Endothelial Dysfunction in Diabetic and Obese Mice via Activation of the AMPK/SIRT1/eNOS Pathway

Antioxidants (Basel).

2022 Jun 28;11(7):1286. doi: 10.3390/antiox11071286.

2093. Mingxian Geng, Fanrui Zhao, Hongyan Lu, Li Fang, Ji Wang, Chunlei Liu, Weihong Min

.

Insights into the hippocampus proteome and phosphorylation modification alterations in C57BL/6 revealed the memory improvement mechanisms of a walnut-derived peptide

Food Res Int.

2022 Jun:156:111311. doi: 10.1016/j.foodres.2022.111311.

(IF 4.972)

2094. Tao Zhang, Guowei Cheng, Ping Chen, Yue Peng, Lei Liu, Runze Li, Bin Qiu

.

RS1 gene is a novel prognostic biomarker for lung adenocarcinoma

Thorac Cancer.

2022 Jun;13(12):1850-1861. doi: 10.1111/1759-7714.14471.

(IF 2.61)

2095. Songlin Fang, Lezeng Wang, Chunmei Luo, Hang Yi, Xiangrui Wang, Bo Ning

.

Curcumol inhibits the growth of xenograft-tumors in mice and the biological activities of pancreatic cancer cells by regulating the miR-21-5p/SMAD7 axis

Cell Cycle.

2022 Jun;21(12):1249-1266. doi: 10.1080/15384101.2022.2046983.

(IF 3.699)

2096. Bojiao Ding, Weiqing Niu, Siyi Wang, Fan Zhang, Haiqing Wang, Xuetong Chen, Sen Chen, Shuangxin Ma, Wenhui Kang, Mingjuan Wang, Liang Li, Wei Xiao, Zihu Guo, Yonghua Wang

.

Centella asiatica (L.) Urb. attenuates cardiac hypertrophy and improves heart function through multi-level mechanisms revealed by systems pharmacology

J Ethnopharmacol.

2022 Jun 12:291:115106. doi: 10.1016/j.jep.2022.115106.

(IF 3.69)

2097. Jiahuan Liu, Mingzhu Pan, Dong Huang, Jing Wu, Yue Liu, Yanlin Guo, Wenbing Zhang, Kangsen Mai

.

High glucose induces apoptosis, glycogen accumulation and suppresses protein synthesis in muscle cells of olive flounder Paralichthys olivaceus

Br J Nutr.

2022 Jun 14;127(11):1601-1612. doi: 10.1017/S0007114521002634.

2098. Meiying Feng, Kai Wang, Shuying Fu, Hengxi Wei, Xiaokun Mu, Li Li, Shouquan Zhang

.

Tubulin TUBB4B Is Involved in Spermatogonia Proliferation and Cell Cycle Processes

Genes (Basel).

2022 Jun 17;13(6):1082. doi: 10.3390/genes13061082.

2099. Jiao Liang, Yan Shen, Yi Wang, Yuxiao Huang, Jun Wang, Qinghao Zhu, Guodong Tong, Kangjie Yu, Wei Cao, Qi Wang, Yinghui Li, Ya Zhao

.

Ferroptosis participates in neuron damage in experimental cerebral malaria and is partially induced by activated CD8+ T cells

Mol Brain.

2022 Jun 20;15(1):57. doi: 10.1186/s13041-022-00942-7.

(IF 4.686)

2100. Junhua Li, Xiaotong Ye, Yang Zhou, Shiqiao Peng, Peibing Zheng, Xiaoxiao Zhang, Jiajun Yang, Yanhong Xu

.

Energy Metabolic Disorder of Astrocytes May Be an Inducer of Migraine Attack

Brain Sci.

2022 Jun 28;12(7):844. doi: 10.3390/brainsci12070844.

(IF 3.332)

2101. Xinlong Wan, Xuan Shi, Mengke Li, Qing Chen, Chang Xue, Guanghui Li, Yeke Huang, Jingwen Yang, Chan Chen, Zhiyi Wang, Shumei Ma, Xiaodong Liu

.

The Protective Effects and Mechanism of Doxepin on Radiation-Induced Lung Injury in Rats

Dose Response.

2022 Jun 7;20(2):15593258221107193. doi: 10.1177/15593258221107193.

2102. Xin Huang, Yiran Liu, Hong Shen, Tingting Fu, Yan Guo, Sainan Qiu

.

Chlorogenic acid attenuates inflammation in LPS-induced Human gingival fibroblasts via CysLT1R/Nrf2/NLRP3 signaling

Int Immunopharmacol.

2022 Jun:107:108706. doi: 10.1016/j.intimp.2022.108706.

(IF 3.943)

2103. Yafang Zhong, Wei Zhang, Haiyan Yu, Liewen Lin, Xucan Gao, Jingquan He, Dandan Li, Yumei Chen, Zhipeng Zeng, Yong Xu, Donge Tang, Yong Dai

.

Multi-platform-based characterization of ferroptosis in human colorectal cancer

iScience.

2022 Jul 15;25(8):104750. doi: 10.1016/j.isci.2022.104750.

2104. Xiaodong Zhang, Ligang Liu, Danyang Liu, Yongtao Li, Jun He, Lei Shen

.

17β-Estradiol promotes angiogenesis of bone marrow mesenchymal stem cells by upregulating the PI3K-Akt signaling pathway

Comput Struct Biotechnol J.

2022 Jul 19:20:3864-3873. doi: 10.1016/j.csbj.2022.07.028.

2105. Chengfang Zhang, Han Li, Yabin Yan, Xiyan Zhang, Zhilan Tu

.

5:2 intermittent fasting tapers food intake in the refeeding state and ameliorates metabolic disturbances in mice exposed to olanzapine

Front Psychiatry.

2022 Jul 25:13:926251. doi: 10.3389/fpsyt.2022.926251.

(IF 2.849)

2106. Qiong Huang, Xiao Wang, An Chen, Hua Zhang, Qimeng Yu, Chenfeng Shen, Annoor Awadasseid, Xiaoyin Zhao, Xuqiong Xiong, Yanling Wu, Wen Zhang

.

Design, synthesis and anti-tumor activity of novel benzothiophenonaphthalimide derivatives targeting mitochondrial DNA (mtDNA) G-quadruplex

Biochem Pharmacol.

2022 Jul:201:115062. doi: 10.1016/j.bcp.2022.115062.

(IF 4.96)

2107. Zili Lei, Hedong Rong, Yanhong Yang, Siping Yu, Tianle Zhang, Lei Chen, Ya Nie, Qi Song, Qing Hu, Jiao Guo

.

Loperamide induces excessive accumulation of bile acids in the liver of mice with different diets

Toxicology.

2022 Jul:477:153278. doi: 10.1016/j.tox.2022.153278.

(IF 4.099)

2108. You-Ping Li, Yue Liu, Li-Min Xiao, Li-Ke Chen, Er-Xing Tao, Er-Ming Zeng, Chun-Hua Xu

.

Induction of cancer cell stemness in glioma through glycolysis and the long noncoding RNA HULC-activated FOXM1/AGR2/HIF-1α axis

Lab Invest.

2022 Jul;102(7):691-701. doi: 10.1038/s41374-021-00664-9.

(IF 4.197)

2109. Mingxiao Wen, Xiaoqing Dou, Shuzhen Zhang, Bin Wang, Jiangyan Xu, Wenchao Zhang, Feifei Wang

.

CTBP1‑AS upregulation is associated with polycystic ovary syndrome and can be effectively downregulated by cryptotanshinone

Mol Med Rep.

2022 Jul;26(1):245. doi: 10.3892/mmr.2022.12761.

(IF 2.1)

2110. Pengcheng Xia, Jing Chen, Yingchao Liu, Xiaolin Cui, Cuicui Wang, Shuai Zong, Le Wang, Zhiming Lu

.

MicroRNA-22-3p ameliorates Alzheimer's disease by targeting SOX9 through the NF-κB signaling pathway in the hippocampus

J Neuroinflammation.

2022 Jul 12;19(1):180. doi: 10.1186/s12974-022-02548-1.

2111. Daojiang Yu, Yahui Feng, Zhiqiang Jiang, Tao Yan, Kai Fang, Yuhong Shi, Jie Zhang, Shuyu Zhang

.

The role of human antigen R (HuR) in modulating proliferation, senescence and radiosensitivity of skin cells

Exp Ther Med.

2022 Jul 12;24(3):566. doi: 10.3892/etm.2022.11503.

(IF 1.785)

2112. Qian Wang, Zhenzhen Sun, Shihan Cao, Xiuli Lin, Mengying Wu, Yuanyuan Li, Jie Yin, Wei Zhou, Songming Huang, Aihua Zhang, Yue Zhang, Weiwei Xia, Zhanjun Jia

.

Reduced Immunity Regulator MAVS Contributes to Non-Hypertrophic Cardiac Dysfunction by Disturbing Energy Metabolism and Mitochondrial Homeostasis

Front Immunol.

2022 Jul 1:13:919038. doi: 10.3389/fimmu.2022.919038.

(IF 5.085)

2113. Hanlin Ma, Gonghua Qi, Fang Han, Jiali Peng, Cunzhong Yuan, Beihua Kong

.

PBK drives PARP inhibitor resistance through the TRIM37/NFκB axis in ovarian cancer

Exp Mol Med.

2022 Jul;54(7):999-1010. doi: 10.1038/s12276-022-00809-w.

(IF 5.418)

2114. Yu Tang, Yu Han, Weixia Zhang, Yihan Yu, Lin Huang, Weishang Zhou, Wei Shi, Dandan Tian, Guangxu Liu

.

Bisphenol A and microplastics weaken the antimicrobial ability of blood clams by disrupting humoral immune responses and suppressing hemocyte chemotactic activity

Environ Pollut.

2022 Aug 15:307:119497. doi: 10.1016/j.envpol.2022.119497.

(IF 6.792)

2115. Cong Pang, Sen Gao, Xun-Zhi Liu, Xiao-Jian Li, Zheng Peng, Hua-Sheng Zhang, Yan Zhou, Xiang-Xin Chen, Tao Tao, Yue Lu, Wei Li, Chun-Hua Hang

.

Astrocytic CD24 Protects Neuron from Recombinant High-Mobility Group Box 1 Protein(rHMGB1)-Elicited Neuronal Injury

Brain Sci.

2022 Aug 23;12(9):1119. doi: 10.3390/brainsci12091119.

(IF 3.332)

2116. Weiwei Yuan, Jinxi Huang, Shanshan Hou, Huahua Li, Liangyu Bie, Beibei Chen, Gaofeng Li, Yang Zhou, Xiaobing Chen

.

The Antigastric Cancer Effect of Triptolide is Associated With H19/NF-κB/FLIP Axis

Front Pharmacol.

2022 Aug 30:13:918588. doi: 10.3389/fphar.2022.918588.

(IF 4.225)

2117. Ruiqi Xu, Ling Ma, Timson Chen, Jing Wang

.

Sophorolipid Suppresses LPS-Induced Inflammation in RAW264.7 Cells through the NF-κB Signaling Pathway

Molecules.

2022 Aug 8;27(15):5037. doi: 10.3390/molecules27155037.

(IF 3.267)

2118. Doudou Jing, Wei Wu, Xuanzuo Chen, Hongwei Xiao, Zhenhao Zhang, Fengxia Chen, Zhicai Zhang, Jianxiang Liu, Zengwu Shao, Feifei Pu

.

Quercetin encapsulated in folic acid-modified liposomes is therapeutic against osteosarcoma by non-covalent binding to the JH2 domain of JAK2 Via the JAK2-STAT3-PDL1

Pharmacol Res.

2022 Aug:182:106287. doi: 10.1016/j.phrs.2022.106287.

(IF 5.893)

2119. Fangxing Hou, Xing Li, Yanfeng Wang, Xiangzuo Xiao

.

MicroRNA-183 accelerates the proliferation of hepatocyte during liver regeneration through targeting programmed cell death protein 6

Genes Genomics.

2022 Aug;44(8):1017-1029. doi: 10.1007/s13258-022-01223-2.

2120. Huanhuan Cui, Hongyang Yi, Hongyu Bao, Ying Tan, Chi Tian, Xinyao Shi, Diwen Gan, Bin Zhang, Weizheng Liang, Rui Chen, Qionghua Zhu, Liang Fang, Xin Gao, Hongda Huang, Ruijun Tian, Silke R Sperling, Yuhui Hu, Wei Chen

.

The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling

Nat Commun.

2022 Aug 9;13(1):4680. doi: 10.1038/s41467-022-32472-0.

(IF 12.121)

2121. Wentao Chen, Hao Luo, Lihong Zeng, Yuying Pan, Jonathan B Parr, Yinbo Jiang, Clark H Cunningham, Kelly L Hawley, Justin D Radolf, Wujian Ke, Jiangli Ou, Jianjiang Yang, Bin Yang, Heping Zheng

.

A suite of PCR-LwCas13a assays for detection and genotyping of Treponema pallidum in clinical samples

Nat Commun.

2022 Aug 9;13(1):4671. doi: 10.1038/s41467-022-32250-y.

(IF 12.121)

2122. Javad Harati, Xuelian Tao, Hosein Shahsavarani, Ping Du, Massimiliano Galluzzi, Kun Liu, Zhen Zhang, Peter Shaw, Mohammad Ali Shokrgozar, Haobo Pan, Peng-Yuan Wang

.

Polydopamine-Mediated Protein Adsorption Alters the Epigenetic Status and Differentiation of Primary Human Adipose-Derived Stem Cells (hASCs)

Front Bioeng Biotechnol.

2022 Aug 10:10:934179. doi: 10.3389/fbioe.2022.934179.

2123. Jing Zhang, Yongping Zheng, Yun Wang, Jin Wang, Aming Sang, Xuemin Song, Xinyi Li

.

YAP1 alleviates sepsis-induced acute lung injury via inhibiting ferritinophagy-mediated ferroptosis

Front Immunol.

2022 Aug 1:13:884362. doi: 10.3389/fimmu.2022.884362.

(IF 5.085)

2124. Huiling Hu, Xue Yang, Yuqing He, Chaohui Duan, Nannan Sun

.

Psychological stress induces depressive-like behavior associated with bone marrow-derived monocyte infiltration into the hippocampus independent of blood-brain barrier disruption

J Neuroinflammation.

2022 Aug 24;19(1):208. doi: 10.1186/s12974-022-02569-w.

2125. Li Zhou, Yonglong Han, Quanjun Yang, Bo Xin, Mengyi Chi, Yan Huo, Cheng Guo, Xipeng Sun

.

Scutellarin attenuates doxorubicin-induced oxidative stress, DNA damage, mitochondrial dysfunction, apoptosis and autophagy in H9c2 cells, cardiac fibroblasts and HUVECs

Toxicol In Vitro.

2022 Aug:82:105366. doi: 10.1016/j.tiv.2022.105366.

(IF 2.959)

2126. Jinyuan Luoqian, Wenyong Yang, Xulong Ding, Qing-Zhang Tuo, Zheng Xiang, Zhaoyue Zheng, Yu-Jie Guo, Li Li, Pengbo Guan, Scott Ayton, Biao Dong, Huiyuan Zhang, Hongbo Hu, Peng Lei

.

Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis

Cell Mol Immunol.

2022 Aug;19(8):913-924. doi: 10.1038/s41423-022-00883-0.

(IF 8.484)

2127. Xiaoyang Wang, Weili Cheng, Xiaopan Chen, Yanan Gong, Guangjie Wang, Xiaoxue Zhang, Yuanyuan Qi

.

Inhibition of CEBPB Attenuates Lupus Nephritis via Regulating Pim-1 Signaling

Mediators Inflamm.

2022 Sep 20:2022:2298865. doi: 10.1155/2022/2298865.

2128. Linhao Jiang, Rui Dong, Minhui Xu, Yujia Liu, Jiyan Xu, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu

.

Inhibition of the integrated stress response reverses oxidative stress damage-induced postoperative cognitive dysfunction

Front Cell Neurosci.

2022 Sep 21:16:992869. doi: 10.3389/fncel.2022.992869.

(IF 3.921)

2129. Jing-Tao Wen, Xi Chen, Xin Liu, Bu-Min Xie, Jing-Wen Chen, Hong-Lei Qin, Yang Zhao

.

Small Nucleolar RNA and C/D Box 15B Regulate the TRIM25/P53 Complex to Promote the Development of Endometrial Cancer

J Oncol.

2022 Sep 26:2022:7762708. doi: 10.1155/2022/7762708.

(IF 2.206)

2130. Chunxia Liu, Shenglin Pei, Huijun Dai, Zhen Liu, Mengling Ye, Hao Liu, Xiaojing He, Siyi Wu, Yi Qin, Fei Lin

.

Downregulation of SIRT3 Aggravates Lung Ischemia Reperfusion Injury by Increasing Mitochondrial Fission and Oxidative Stress through HIF-1 α-Dependent Mechanisms

Oxid Med Cell Longev.

2022 Sep 29:2022:9041914. doi: 10.1155/2022/9041914.

(IF 5.076)

2131. Lei Jia, Bo Li, Cong Fang, Xiaoyan Liang, Yingjun Xie, Xiaofang Sun, Wen Wang, Lei Zheng, Ding Wang

.

Extracellular Vesicles of Mesenchymal Stem Cells Are More Effectively Accessed through Polyethylene Glycol-Based Precipitation than by Ultracentrifugation

Stem Cells Int.

2022 Sep 6:2022:3577015. doi: 10.1155/2022/3577015.

(IF 3.869)

2132. Feng Shi, Zhiwei Wang, Qi Wu, Xiaohan Zhong, Min Zhang, Bowen Li, Wei Ren, Shun Yuan, Yuanyang Chen

.

Iron deficiency promotes aortic media degeneration by activating endoplasmic reticulum stress-mediated IRE1 signaling pathway

Pharmacol Res.

2022 Sep:183:106366. doi: 10.1016/j.phrs.2022.106366.

(IF 5.893)

2133. Weiyuan Yang, Xin Li, Guiyun Jiang, Yu Long, Hui Li, Shujun Yu, Huina Zhao, Juanxu Liu

.

Crotonylation versus acetylation in petunia corollas with reduced acetyl-CoA due to PaACL silencing

Physiol Plant.

2022 Sep;174(5):e13794. doi: 10.1111/ppl.13794.

2134. Jiaoyue Zhang, Fanli Wang, Dengbin Wu, Dewei Zhao

.

Revealing the mechanisms of Weishi Huogu I capsules used for treating osteonecrosis of the femoral head based on systems pharmacology with one mechanism validated with in vitro experiments

J Ethnopharmacol.

2022 Sep 15:295:115354. doi: 10.1016/j.jep.2022.115354.

(IF 3.69)

2135. Weili Wang, Zhenyu Liu, Yu Zhang, Liu Wang, Dongwei Meng, Xueqin Li, Jingbo Zhang, Yuzhang Wu, Xinyuan Zhou, Guoxiang Liu

.

Benzyl butyl phthalate (BBP) induces lung injury and fibrosis through neutrophil extracellular traps

Environ Pollut.

2022 Sep 15:309:119743. doi: 10.1016/j.envpol.2022.119743.

(IF 6.792)

2136. Shuang Qu, Qiao Liao, Cheng Yu, Yue Chen, Han Luo, Xuewei Xia, Duofen He, Zaicheng Xu, Pedro A Jose, Zhuxin Li, Wei Eric Wang, Qing Rex Lyu, Chunyu Zeng

.

LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis

Bosn J Basic Med Sci.

2022 Sep 16;22(5):772-783. doi: 10.17305/bjbms.2021.7225.

2137. Yunzheng Li, Binghua Li, Yanchao Xu, Liyuan Qian, Tiancheng Xu, Gang Meng, Huan Li, Ye Wang, Laizhu Zhang, Xiang Jiang, Qi Liu, Yuanyuan Xie, Chunxiao Cheng, Beicheng Sun, Decai Yu

.

GOT2 Silencing Promotes Reprogramming of Glutamine Metabolism and Sensitizes Hepatocellular Carcinoma to Glutaminase Inhibitors

Cancer Res.

2022 Sep 16;82(18):3223-3235. doi: 10.1158/0008-5472.CAN-22-0042.

(IF 9.727)

2138. Zhipeng Chen, Chengyu Bian, Jingjing Huang, Xiang Li, Liang Chen, Xueying Xie, Yang Xia, Rong Yin, Jun Wang

.

Tumor-derived exosomal HOTAIRM1 regulates SPON2 in CAFs to promote progression of lung adenocarcinoma

Discov Oncol.

2022 Sep 24;13(1):92. doi: 10.1007/s12672-022-00553-7.

2139. Xiaojin Yu, Hui Yao, Xiaohui Zhang, Lulu Liu, Shuangmei Liu, Youjing Dong

.

Comparison of LPS and MS-induced depressive mouse model: behavior, inflammation and biochemical changes

BMC Psychiatry.

2022 Sep 5;22(1):590. doi: 10.1186/s12888-022-04233-2.

(IF 2.704)

2140. Zhichu Chen, Dong Huang, Prakaiwan Yongyut, Guangbin Li, María Ángeles Esteban, Orapint Jintasataporn, Junming Deng, Wenbing Zhang, Qinghui Ai, Kangsen Mai, Yanjiao Zhang

.

Vitamin D3 deficiency induced intestinal inflammatory response of turbot through nuclear factor-κB/inflammasome pathway, accompanied by the mutually exclusive apoptosis and autophagy

Front Immunol.

2022 Sep 8:13:986593. doi: 10.3389/fimmu.2022.986593.

(IF 5.085)

2141. Zhitao Jiang, Xiang Yang, Yi Han, Jie Li, Chen Hu, Chundi Liu, Wei Xiao

.

Sarmentosin promotes USP17 and regulates Nrf2-mediated mitophagy and cellular oxidative stress to alleviate APAP-induced acute liver failure

Phytomedicine.

2022 Sep:104:154337. doi: 10.1016/j.phymed.2022.154337.

(IF 4.268)

2142. Yaoguang Gu, Juan Bai, Jiayan Zhang, Yansheng Zhao, Ruirong Pan, Ying Dong, Henglin Cui, Ranhui Meng, Xiang Xiao

.

Lactiplantibacillus plantarum fermented barley extracts ameliorate high-fat-diet-induced muscle dysfunction via mitophagy

J Sci Food Agric.

2022 Sep;102(12):5261-5271. doi: 10.1002/jsfa.11879.

2143. Hongyu Li, Boying Wang, Benquan Qi, Guojun Jiang, Min Qin, Meiling Yu

.

Connexin32 regulates expansion of liver cancer stem cells via the PI3K/Akt signaling pathway

Oncol Rep.

2022 Sep;48(3):166. doi: 10.3892/or.2022.8381.

(IF 3.417)

2144. Hongjuan Yao, Wenping Song, Rui Cao, Cheng Ye, Li Zhang, Hebing Chen, Junting Wang, Yuchen Shi, Rui Li, Yi Li, Xiujun Liu, Xiaofei Zhou, Rongguang Shao, Liang Li

.

An EGFR/HER2-targeted conjugate sensitizes gemcitabine-sensitive and resistant pancreatic cancer through different SMAD4-mediated mechanisms

Nat Commun.

2022 Sep 20;13(1):5506. doi: 10.1038/s41467-022-33037-x.

(IF 12.121)

2145. Siyuan Dai, Xiaoyin Tang, Lili Li, Takao Ishidate, Ahmet R Ozturk, Hao Chen, Altair L Dude, Yong-Hong Yan, Meng-Qiu Dong, En-Zhi Shen, Craig C Mello

.

A family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing

Cell Rep.

2022 Sep 6;40(10):111265. doi: 10.1016/j.celrep.2022.111265.

(IF 8.109)

2146. Peng Sun, Xuan Yang

.

Hsa_circ_0097271 Knockdown Attenuates Osteosarcoma Progression via Regulating miR-640/MCAM Pathway

Dis Markers.

2022 Oct 26:2022:8084034. doi: 10.1155/2022/8084034.

(IF 2.738)

2147. Lingjun Dong, Fuxiang Liang, Zhiling Lou, Yangfan Li, Jinsheng Li, Yaling Chen, Jingjing Ding, Bin Jiang, Chuanqiang Wu, Huan Yu, Yafei Liu, Weiping Zhang, Yunbi Lu, Ming Wu

.

Necrostatin-1 Alleviates Lung Ischemia-Reperfusion Injury via Inhibiting Necroptosis and Apoptosis of Lung Epithelial Cells

Cells.

2022 Oct 6;11(19):3139. doi: 10.3390/cells11193139.

(IF 4.366)

2148. Lu Liu, Jun Chen, Meng-Meng Wang, Yuanlei Huang, Yong Qian, Xuling Xue, Zhi Su, Hong-Ke Liu

.

The cyclometalated iridium (III) complex based on 9-Anthracenecarboxylic acid as a lysosomal-targeted anticancer agent

J Inorg Biochem.

2022 Oct:235:111913. doi: 10.1016/j.jinorgbio.2022.111913.

(IF 3.212)

2149. Jiangliu Xie, Bo Wang, Wenjie Luo, Chen Li, Xunchao Jia

.

Upregulation of KIF18B facilitates malignant phenotype of esophageal squamous cell carcinoma by activating CDCA8/mTORC1 pathway

J Clin Lab Anal.

2022 Oct;36(10):e24633. doi: 10.1002/jcla.24633.

(IF 1.54)

2150. Hong-Yang Shu, Yi-Zhong Peng, Wei-Jian Hang, Min Zhang, Lan Shen, Dao-Wen Wang, Ning Zhou

.

Trimetazidine enhances myocardial angiogenesis in pressure overload-induced cardiac hypertrophy mice through directly activating Akt and promoting the binding of HSF1 to VEGF-A promoter

Acta Pharmacol Sin.

2022 Oct;43(10):2550-2561. doi: 10.1038/s41401-022-00877-8.

(IF 5.064)

2151. Xiao-Wen Zhang, Lu-Yi Wu, Hui-Rong Liu, Yan Huang, Qin Qi, Rui Zhong, Lu Zhu, Chun-Fang Gao, Lin Zhou, Jian Yu, Huan-Gan Wu

.

NSUN5 promotes progression and predicts poor prognosis in hepatocellular carcinoma

Oncol Lett.

2022 Oct 21;24(6):439. doi: 10.3892/ol.2022.13559.

(IF 2.311)

2152. Mengmeng Song, Xianjie Sheng, Jianrong Zhang, Xinru Li, Qianyun Dai, Yan Chen, An Kang

.

Homeostatic regulation of the aryl hydrocarbon receptor-cytochrome P450 1a axis by Scutellaria baicalensis-Coptis chinensis herb pair and its main constituents

J Ethnopharmacol.

2022 Oct 28:297:115545. doi: 10.1016/j.jep.2022.115545.

(IF 3.69)

2153. Xinli Dong, Yanhua Wang, Hua Zhuang, Gang An

.

Hydroxygenkwanin suppresses proliferation, invasion and migration of osteosarcoma cells via the miR‑320a/SOX9 axis

Mol Med Rep.

2022 Oct;26(4):299. doi: 10.3892/mmr.2022.12815.

(IF 2.1)

2154. Lei Wang, Min Li, Cuiping Zhu, Aiping Qin, Jinchun Wang, Xianni Wei

.

The protective effect of Palmatine on depressive like behavior by modulating microglia polarization in LPS-induced mice

Neurochem Res.

2022 Oct;47(10):3178-3191. doi: 10.1007/s11064-022-03672-3.

(IF 3.038)

2155. Qinying Liu, Yi Yang, Miaomiao Cheng, Fangting Cheng, Shanshan Chen, Qiuhong Zheng, Yang Sun, Li Chen

.

The marine natural product, dicitrinone B, induces apoptosis through autophagy blockade in breast cancer

Int J Mol Med.

2022 Oct;50(4):130. doi: 10.3892/ijmm.2022.5186.

(IF 3.098)

2156. Zixiang Wang, Shourong Wang, Junchao Qin, Xiyu Zhang, Gang Lu, Hongbin Liu, Haiyang Guo, Ligang Wu, Victoria O Shender, Changshun Shao, Beihua Kong, Zhaojian Liu

.

Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12

Nat Commun.

2022 Oct 21;13(1):6246. doi: 10.1038/s41467-022-34042-w.

(IF 12.121)

2157. Xuedong Chen, Yongfeng Wang, Yujun Wang, Qiuying Li, Xinyin Liang, Guang Wang, Jianglan Li, Ruji Peng, Yanghu Sima, Shiqing Xu

.

Ectopic expression of sericin enables efficient production of ancient silk with structural changes in silkworm

Nat Commun.

2022 Oct 22;13(1):6295. doi: 10.1038/s41467-022-34128-5.

(IF 12.121)

2158. Wan Chang, Qingyu Luo, Xiaowei Wu, Yabing Nan, Pengfei Zhao, Lingqiang Zhang, Aiping Luo, Wenjie Jiao, Qiong Zhu, Yesheng Fu, Zhihua Liu

.

OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis

Cell Rep.

2022 Oct 25;41(4):111561. doi: 10.1016/j.celrep.2022.111561.

(IF 8.109)

2159. Hua Han, Xiaofeng Xu

.

MiR-205 Promotes the Viability, Migration, and Tube Formation of Cervical Cancer Cells In Vitro by Targeting GATA3

Cancer Biother Radiopharm.

2022 Nov;37(9):779-791. doi: 10.1089/cbr.2020.4184.

2160. Hua Chang, Xue Zhang, Baixue Li, Xiangkai Meng

.

PARP1 Is Targeted by miR-519a-3p and Promotes the Migration, Invasion, and Tube Formation of Ovarian Cancer Cells

Cancer Biother Radiopharm.

2022 Nov;37(9):824-836. doi: 10.1089/cbr.2020.4394.

2161. Xin Yang, Fengyan Zhang, Xuhui Liu, Jia Meng, Shanshan Du, Jingzhi Shao, Jingjing Liu, Mengyuan Fang

.

FOXO4 mediates resistance to oxidative stress in lens epithelial cells by modulating the TRIM25/Nrf2 signaling

Exp Cell Res.

2022 Nov 1;420(1):113340. doi: 10.1016/j.yexcr.2022.113340.

(IF 3.383)

2162. Sheng-Qing Gao, Jia-Jun Shi, Xue-Wang, Shu-Hao Miao, Tao Li, Chao-Chao Gao, Yan-Ling Han, Jia-Yin Qiu, Yun-Song Zhuang, Meng-Liang Zhou

.

Endothelial NOX4 aggravates eNOS uncoupling by decreasing dihydrofolate reductase after subarachnoid hemorrhage

Free Radic Biol Med.

2022 Nov 20;193(Pt 2):499-510. doi: 10.1016/j.freeradbiomed.2022.10.318.

2163. Gao-Shang Chai, Jia-Jun Wu, Juan Gong, Jia-Li Zhou, Zhi-Qian Jiang, Hai-Yan Yi, Yu Gu, Hao-Hua Huang, Zhe-Yu Yao, Yu-Qi Zhang, Peng Zhao, Yun-Juan Nie

.

Activation of β2-adrenergic Receptor Ameliorates Amyloid-β-induced Mitophagy Defects and Tau Pathology in Mice

Neuroscience.

2022 Nov 21:505:34-50. doi: 10.1016/j.neuroscience.2022.09.020.

(IF 3.056)

2164. Lei Cao, Huixiang Tian, Man Fang, Zhe Xu, Dongsheng Tang, Juan Chen, Jiye Yin, Haihua Xiao, Kun Shang, Hongbin Han, Xiangping Li

.

Activating cGAS-STING pathway with ROS-responsive nanoparticles delivering a hybrid prodrug for enhanced chemo-immunotherapy

Biomaterials.

2022 Nov:290:121856. doi: 10.1016/j.biomaterials.2022.121856.

(IF 10.317)

2165. Shan Yu, Changyong E, Jinghui Yang

.

STAM binding protein regulated by hsa_circ_0007334 exerts oncogenic potential in pancreatic cancer

Pancreatology.

2022 Nov;22(7):1003-1012. doi: 10.1016/j.pan.2022.08.010.

(IF 3.629)

2166. Yanyin Zhao, Yu Chen, Zhiwei Wang, Changli Xu, Suchi Qiao, Tianze Liu, Ke Qi, Dake Tong, Cheng Li

.

Bone Marrow Mesenchymal Stem Cell Exosome Attenuates Inflammasome-Related Pyroptosis via Delivering circ_003564 to Improve the Recovery of Spinal Cord Injury

Mol Neurobiol.

2022 Nov;59(11):6771-6789. doi: 10.1007/s12035-022-03006-y.

(IF 4.5)

2167. Jinxia Ao, Zonghua Ma, Rui Li, Sen Zhang, Xuejun Gao, Minghui Zhang

.

Phospho-Tudor-SN coordinates with STAT5 to regulate prolactin-stimulated milk protein synthesis and proliferation of bovine mammary epithelial cells

Anim Biotechnol.

2022 Nov;33(6):1161-1169. doi: 10.1080/10495398.2021.1879824.

(IF 1.487)

2168. Hao Wang, Hengxiang Zhang, Yuhan Chen, Huina Wang, Yangzi Tian, Xiuli Yi, Qiong Shi, Tao Zhao, Baolu Zhang, Tianwen Gao, Sen Guo, Chunying Li, Weinan Guo

.

Targeting Wnt/β-Catenin Signaling Exacerbates Ferroptosis and Increases the Efficacy of Melanoma Immunotherapy via the Regulation of MITF

Cells.

2022 Nov 12;11(22):3580. doi: 10.3390/cells11223580.

(IF 4.366)

2169. Hao Zhang, Yaqiao Wang, Kehan Wu, Runmin Liu, Hao Wang, Yongwei Yao, Peter Kvietys, Tao Rui

.

miR‑141 impairs mitochondrial function in cardiomyocytes subjected to hypoxia/reoxygenation by targeting Sirt1 and MFN2

Exp Ther Med.

2022 Nov 14;24(6):763. doi: 10.3892/etm.2022.11699.

(IF 1.785)

2170. Shicheng Sun, Changfa Guo, Taihong Gao, Dengzhen Ma, Xiangsheng Su, Qi Pang, Rui Zhang

.

Hypoxia Enhances Glioma Resistance to Sulfasalazine-Induced Ferroptosis by Upregulating SLC7A11 via PI3K/AKT/HIF-1 α Axis

Oxid Med Cell Longev.

2022 Nov 18:2022:7862430. doi: 10.1155/2022/7862430.

(IF 5.076)

2171. Bowen Meng, Di Jiang, Delin Kong, Yunqin Yan, Yuzhe Nie, Chun-Bo Teng, Yang Liang

.

MiR-18 inhibitor promotes the differentiation of bovine skeletal muscle-derived satellite cells by increasing MEF2D expression

J Anim Sci.

2022 Nov 1;100(11):skac238. doi: 10.1093/jas/skac238.

(IF 2.092)

2172. Caiji Lin, Zheng Zeng, Yiru Lin, Pengfei Wang, Danli Cao, Kaihong Xie, Yao Luo, Hao Yang, Jiaming Yang, Wenxue Wang, LingJie Luo, Huihui Lin, Hang Chen, Yufan Zhao, Yongwei Shi, Zixiang Gao, Huidi Liu, Shu-Lin Liu

.

Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota

Phytomedicine.

2022 Nov:106:154401. doi: 10.1016/j.phymed.2022.154401.

(IF 4.268)

2173. Jinqing Huang, Lang Hong, Binghua Shen, Yunying Zhou, Jianyun Lan, Ying Peng

.

FOXO1 represses MCL1 transcription to regulate the function of vascular smooth muscle cells in intracranial aneurysm

Exp Brain Res.

2022 Nov;240(11):2861-2870. doi: 10.1007/s00221-022-06461-0.

(IF 1.591)

2174. Xiangliang Tang, Dian Li, Tianxin Zhao, Shibo Zhu, Xiaofeng Gao, Rui Zhou, Fuming Deng, Wen Fu, Wei Jia, Guochang Liu

.

The inhibition of CFTR in the descended testis of SD rats with unilateral cryptorchidism induced by di-(2-ethylhexyl) phthalate (DEHP)

Environ Sci Pollut Res Int.

2022 Nov;29(51):77047-77056. doi: 10.1007/s11356-022-21134-9.

2175. Jie Yu, Yao Cheng, Yaru Cui, Yujie Zhai, Wenshen Zhang, Mengdi Zhang, Wenyu Xin, Jia Liang, Xiaohong Pan, Qiaoyun Wang, Hongliu Sun

.

Anti-Seizure and Neuronal Protective Effects of Irisin in Kainic Acid-Induced Chronic Epilepsy Model with Spontaneous Seizures

Neurosci Bull.

2022 Nov;38(11):1347-1364. doi: 10.1007/s12264-022-00914-w.

(IF 4.326)

2176. Bingyan Wei, Tao Zhang, Pengyu Wang, Yihui Pan, Jiahui Li, Weizhong Chen, Min Zhang, Quanjiang Ji, Wenjuan Wu, Lefu Lan, Jianhua Gan, Cai-Guang Yang

.

Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP

Nat Commun.

2022 Nov 14;13(1):6909. doi: 10.1038/s41467-022-34753-0.

(IF 12.121)

2177. Jing Gu, Rui-Kun Peng, Chun-Ling Guo, Meng Zhang, Jie Yang, Xiao Yan, Qian Zhou, Hongwei Li, Na Wang, Jinwei Zhu, Qin Ouyang

.

Construction of a synthetic methodology-based library and its application in identifying a GIT/PIX protein-protein interaction inhibitor

Nat Commun.

2022 Nov 23;13(1):7176. doi: 10.1038/s41467-022-34598-7.

(IF 12.121)

2178. Jing Yan, Yuemei Zhang, Hairong Yu, Yicen Zong, Daixi Wang, Jiangfei Zheng, Li Jin, Xiangtian Yu, Caizhi Liu, Yi Zhang, Feng Jiang, Rong Zhang, Xiangnan Fang, Ting Xu, Mingyu Li, Jianzhong Di, Yan Lu, Xinran Ma, Jian Zhang, Weiping Jia, Cheng Hu

.

GPSM1 impairs metabolic homeostasis by controlling a pro-inflammatory pathway in macrophages

Nat Commun.

2022 Nov 25;13(1):7260. doi: 10.1038/s41467-022-34998-9.

(IF 12.121)

2179. Liyuan Ran, Jinhui Yu, Rui Ma, Qing Yao, Mingjie Wang, Yuping Bi, Zichao Yu, Yingjie Wu

.

Microalgae oil from Schizochytrium sp. alleviates obesity and modulates gut microbiota in high-fat diet-fed mice

Food Funct.

2022 Dec 13;13(24):12799-12813. doi: 10.1039/d2fo01772e.

(IF 4.171)

2180. Xinghe Chen, Xiaozhen Wei, Saijie Ma, Huating Xie, Sirui Huang, Mengge Yao, Li Zhang

.

Cysteine and glycine rich protein 2 exacerbates vascular fibrosis in pulmonary hypertension through the nuclear translocation of yes-associated protein and transcriptional coactivator with PDZ-binding

Toxicol Appl Pharmacol.

2022 Dec 15:457:116319. doi: 10.1016/j.taap.2022.116319.

2181. Xiaoxue Ma, Yiru Wang, Qi Liu, Baihe Han, Gang Wang, Ruoxi Zhang, Xingtao Huang, Xuedong Wang, Mengyue Yang, Chun Xing, Jingbo Hou, Bo Yu

.

Vaspin alleviates the lncRNA LEF1-AS1-induced osteogenic differentiation of vascular smooth muscle cells via the Hippo/YAP signaling pathway

Exp Cell Res.

2022 Dec 15;421(2):113407. doi: 10.1016/j.yexcr.2022.113407.

(IF 3.383)

2182. Wanying Liu, Ke Li, Menglin Zheng, Ling He, Tong Chen

.

Genipin Attenuates Diabetic Cognitive Impairment by Reducing Lipid Accumulation and Promoting Mitochondrial Fusion via FABP4/Mfn1 Signaling in Microglia

Antioxidants (Basel).

2022 Dec 29;12(1):74. doi: 10.3390/antiox12010074.

2183. Qing Li, Liren Zhang, Wenhua You, Jiali Xu, Jingjing Dai, Dongxu Hua, Ruizhi Zhang, Feifan Yao, Suiqing Zhou, Wei Huang, Yongjiu Dai, Yu Zhang, Tasiken Baheti, Xiaofeng Qian, Liyong Pu, Jing Xu, Yongxiang Xia, Chuanyong Zhang, Jinhai Tang, Xuehao Wang

.

PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells

Nat Commun.

2022 Dec 12;13(1):7677. doi: 10.1038/s41467-022-35469-x.

(IF 12.121)

2184. Zilong Zheng, Guokai Yan, Xiuzhi Li, Yuke Fei, Lingling Sun, Haonan Yu, Yaorong Niu, Weihua Gao, Qing Zhong, Xianghua Yan

.

Lysine crotonylation regulates leucine-deprivation-induced autophagy by a 14-3-3ε-PPM1B axis

Cell Rep.

2022 Dec 20;41(12):111850. doi: 10.1016/j.celrep.2022.111850.

(IF 8.109)

2185. Yayun Gu, Yan Zhou, Sihan Ju, Xiaofei Liu, Zicheng Zhang, Jia Guo, Jimiao Gao, Jie Zang, Hao Sun, Qi Chen, Jinghan Wang, Jiani Xu, Yiqun Xu, Yingjia Chen, Yueshuai Guo, Juncheng Dai, Hongxia Ma, Cheng Wang, Guangfu Jin, Chaojun Li, Yankai Xia, Hongbing Shen, Yang Yang, Xuejiang Guo, Zhibin Hu

.

Multi-omics profiling visualizes dynamics of cardiac development and functions

Cell Rep.

2022 Dec 27;41(13):111891. doi: 10.1016/j.celrep.2022.111891.

(IF 8.109)

2186. Wei Yang, Bo Mu, Jing You, Chenyu Tian, Huachao Bin, Zhiqiang Xu, Liting Zhang, Ronggang Ma, Ming Wu, Guo Zhang, Chong Huang, Linli Li, Zhenhua Shao, Lunzhi Dai, Laurent Désaubry, Shengyong Yang

.

Non-classical ferroptosis inhibition by a small molecule targeting PHB2

Nat Commun.

2022 Dec 3;13(1):7473. doi: 10.1038/s41467-022-35294-2.

(IF 12.121)

2187. Feng Chen, Yingjie Wu, Lu Ke, Xinyi Lin, Fengchao Wang, Yinghe Qin

.

ARHGEF15 in Sertoli cells contributes to germ cell development and testicular immune privilege†

Biol Reprod.

2022 Dec 10;107(6):1565-1579. doi: 10.1093/biolre/ioac166.

(IF 3.322)

2188. Ying Zhou, Jia-Jie Yang, Yuan Cheng, Ge-Xuan Feng, Rong-Hui Yang, Yuan Yuan, Li-Yong Wang, Miao Wang, Lu Kong

.

Loss of Mature Lamin A/C Triggers a Shift in Intracellular Metabolic Homeostasis via AMPKα Activation

Cells.

2022 Dec 9;11(24):3988. doi: 10.3390/cells11243988.

(IF 4.366)

2189. Yun-Qi Zhou, Ke Wang, Xue-Yan Wang, Hong-Yong Cui, Yongxiang Zhao, Ping Zhu, Zhi-Nan Chen

.

SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent manner

Emerg Microbes Infect.

2022 Dec;11(1):1135-1144. doi: 10.1080/22221751.2022.2059403.

2190. Chang Li, Ziyi Wu, Hang Xue, Qiushi Gao, Yahan Zhang, Changming Wang, Ping Zhao

.

Ferroptosis contributes to hypoxic-ischemic brain injury in neonatal rats: Role of the SIRT1/Nrf2/GPx4 signaling pathway

CNS Neurosci Ther.

2022 Dec;28(12):2268-2280. doi: 10.1111/cns.13973.

(IF 4.074)

2191. Weixiang Song, Yindeng Luo, Yajing Zhao, Xinjie Liu, Jiannong Zhao, Jie Luo, Qunxia Zhang, Haitao Ran, Zhigang Wang, Dajing Guo.

.

delivery and trimodal imaging in breast cancer: an in vitro study.

NANOMEDICINE.

VOL. 12, NO. 9.

(IF 4.717)

2192. Yuan Chen, Haofeng Liu, Junwei Zou, Guangxin Cao, Yunfei Li, Chungen Xing, Jindong Wu

.

Exosomal circ_0091741 promotes gastric cancer cell autophagy and chemoresistance via the miR-330-3p/TRIM14/Dvl2/Wnt/β-catenin axis

Hum Cell.

2023 Jan;36(1):258-275. doi: 10.1007/s13577-022-00790-6.

(IF 3.463)

2193. H B Zeng, L H Zhang, D P Yuan, W Wang, X M Su, W X Weng, R Miao, J Y Xu, J Long, Y H Song

.

[Methylophiopogonanone a Inhibits LPS/ATP-Induced Macrophage Pyroptosis via ROS/NLRP3 Pathway]

Mol Biol (Mosk).

2023 Jan-Feb;57(1):106-108. doi: 10.31857/S0026898423010196.

2194. Guanlan Fan, Fan Wang, Yurou Chen, Qian Zheng, Jie Xiong, Qiongying Lv, Kejia Wu, Jiaqiang Xiong, Lei Wei, Dongqing Li, Jiachen Zhang, Wei Zhang, Feng Li

.

The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region

Cell Rep.

2023 Jan 31;42(1):111916. doi: 10.1016/j.celrep.2022.111916.

(IF 8.109)

2195. Yewen Cong, Yujing Hong, Dandan Wang, Pei Cheng, Zhisheng Wang, Changming Xing, Wenxing Sun, Guangfei Xu

.

2,3,7,8-Tetrachlorodibenzo-p-dioxin induces liver lipid metabolism disorder via the ROS/AMPK/CD36 signaling pathway

Toxicol Sci.

2023 Feb 17;191(2):276-284. doi: 10.1093/toxsci/kfac133.

(IF 3.703)

2196. Hanshen Yang, Xiaozhen Zhang, Mengyi Lao, Kang Sun, Lihong He, Jian Xu, Yi Duan, Yan Chen, Honggang Ying, Muchun Li, Chengxiang Guo, Qingsong Lu, Sicheng Wang, Wei Su, Tingbo Liang, Xueli Bai

.

Targeting ubiquitin-specific protease 8 sensitizes anti-programmed death-ligand 1 immunotherapy of pancreatic cancer

Cell Death Differ.

2023 Feb;30(2):560-575. doi: 10.1038/s41418-022-01102-z.

(IF 10.717)

2197. Hongyan Zhang, Lulu Xu, Junwei Xiong, Xinxin Li, Yindong Yang, Yong Liu, Chunfeng Zhang, Qiyu Wang, Jiajia Wang, Pengyu Wang, Xiaobin Wu, Xue Wang, Xiaofeng Zhu, Yanzhong Guan

.

Role of KCC2 in the Regulation of Brain-Derived Neurotrophic Factor on Ethanol Consumption in Rats

Mol Neurobiol.

2023 Feb;60(2):1040-1049. doi: 10.1007/s12035-022-03126-5.

(IF 4.5)

2198. Yulin Su, Junjie Liang, Meiling Zhang, Meng Zhao, Xueqian Xie, Xiaojing Wang, Zengfeng Pan, Shaowei Huang, Rong Yan, Qing Wang, Lian Zhou, Xia Luo

.

Wogonin regulates colonocyte metabolism via PPARγ to inhibit Enterobacteriaceae against dextran sulfate sodium-induced colitis in mice

Phytother Res.

2023 Mar;37(3):872-884. doi: 10.1002/ptr.7677.

(IF 4.087)

2199. Dongxing Cao, Keyu Qian, Ying Zhao, Jie Hong, Haoyan Chen, Xiaohui Wang, Nailin Yang, Cheng Zhang, Jingkai Cao, Keyu Jia, Guangyu Wu, Mingming Zhu, Jun Shen, Ye Zhang, Zhe Cui, Zheng Wang

.

Association of Neutrophil Extracellular Traps with Fistula Healing in Patients with Complex Perianal Fistulizing Crohn's Disease

J Crohns Colitis.

2023 Apr 19;17(4):580-592. doi: 10.1093/ecco-jcc/jjac171.

(IF 8.658)

2200. Lingling Wu, Zhaoyang Fan, Lifei Gu, Jincheng Liu, Zekun Cui, Boyang Yu, Junping Kou, Fang Li

.

QiShenYiQi dripping pill alleviates myocardial ischemia-induced ferroptosis via improving mitochondrial dynamical homeostasis and biogenesis

J Ethnopharmacol.

2023 May 23:308:116282. doi: 10.1016/j.jep.2023.116282.

(IF 3.69)

2201. Duosheng Luo, Yaru Zhao, Zhaoyan Fang, Yating Zhao, Yi Han, Jingyu Piao, Xianglu Rong, Jiao Guo

.

Tianhuang formula regulates adipocyte mitochondrial function by AMPK/MICU1 pathway in HFD/STZ-induced T2DM mice

BMC Complement Med Ther.

2023 Jun 19;23(1):202. doi: 10.1186/s12906-023-04009-5.

2202. Caixia Hu, Xiufen Zhang, Kai Fang, Zijian Guo, Lihua Li

.

LINC00536 Promotes Breast Cancer Progression by Regulating ROCK1 via Sponging of miR-214-5p

Biochem Genet.

2023 Jun;61(3):1163-1184. doi: 10.1007/s10528-022-10304-6.

(IF 2.027)

2203. Weijie Xie, Yanqin Zeng, Yunqiu Zheng, Bin Cai

.

Activated AMPK Protects Against Chronic Cerebral Ischemia in Bilateral Carotid Artery Stenosis Mice

Cell Mol Neurobiol.

2023 Jul;43(5):2325-2335. doi: 10.1007/s10571-022-01312-6.

(IF 3.606)

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碧云天-P0010-BCA蛋白浓度测定试剂盒(增强型)

BCA蛋白浓度测定试剂盒(增强型)

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产品编号

P0010

数量

¥

375.00

产品包装:500次

10

产品包装:

200次

500次

5000次

产品简介

使用说明

相关文件下载

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产品问答

BCA蛋白浓度测定试剂盒(增强型)(Enhanced BCA Protein Assay Kit)是根据目前世界上最常用的两种蛋白浓度检测方法之一BCA法研制而成,实现了蛋白浓度测定的简单、高稳定性、高灵敏度和高兼容性。

和碧云天生产的普通BCA蛋白浓度测定试剂盒相比,灵敏度更高,检测浓度下限达到10μg/ml,最小检测蛋白量达到

0.2μg,待测样品体积为1-20μl。

和碧云天生产的普通BCA蛋白浓度测定试剂盒相比,显色速度更快,相同的样品孵育较短时间即可进行吸光度测定。

在20-1000μg/ml浓度范围内有较好的线性关系。本产品从0.025到0.5mg/ml的标准曲线参考图1。

图1. 本试剂盒蛋白标准曲线的效果图。左上图为加入BCA工作液后37℃分别孵育30、60和120分钟后的吸光度实测效果图,右图为37℃孵育60分钟时的实拍显色效果图。图中数据仅供参考,实际的检测效果可能会略有不同。

BCA法测定蛋白浓度不受绝大部分样品中的化学物质的影响,可以兼容样品中高达5%的SDS,5%的Triton X-100,5%的

Tween 20、60、80。但本试剂盒受螯合剂和略高浓度的还原剂的影响,需确保EDTA低于10mM,无EGTA,二硫苏糖醇(DTT)低于1mM,β-巯基乙醇(β-Mercaptoethanol)低于0.01%。不适用BCA法时建议试用碧云天生产的Bradford蛋白浓度测定试剂盒(P0006)。

BCA蛋白浓度测定试剂盒(增强型)对样品中各种物质的详细的兼容性和普通的BCA蛋白浓度测定试剂盒相同,请参考碧云天如下网页:http://www.beyotime.com/Compatibility Chart For BCA Kit.pdf

每个试剂盒可以检测500个样品。

包装清单:

产品编号

产品名称

包装

P0010-1

BCA试剂 A

100ml

P0010-2

BCA试剂 B

3ml

P0010-3

蛋白标准(BSA)

30mg

P0010-4

蛋白标准配制液

1.5ml

说明书

1份

保存条件:

室温保存。蛋白标准配制成溶液后-20℃冻存。

注意事项:

需酶标仪一台,测定波长为540-595nm之间,562nm最佳。需96孔板。如果没有酶标仪,也可以使用普通的分光光度计测定,但测定时,需根据比色皿的最小检测体积,适当加大BCA工作液的用量使不小于最小检测体积,样品和标准品的用量可相应按比例放大也可不变。使用分光光度计测定蛋白浓度时,每个试剂盒可以测定的样品数量可能会显著减少。

如发现样品稀释液或裂解液本身就有较高背景,请试用碧云天生产的Bradford蛋白浓度测定试剂盒(P0006)。

为了加快BCA法测定蛋白浓度的速度可以适当用微波炉加热,但是切勿过热。

EDTA浓度必须小于10mM,不兼容EGTA。不适用BCA法时,请试用碧云天生产的Bradford蛋白浓度测定试剂盒(P0006)。

本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。

为了您的安全和健康,请穿实验服并戴一次性手套操作。

使用说明:

1.蛋白标准品的准备

a.取1.2ml蛋白标准配制液加入到一管蛋白标准(30mg BSA)中,充分溶解后配制成25mg/ml的蛋白标准溶液。

配制后可立即使用,也可以-20℃长期保存。

b.取适量25mg/ml蛋白标准,稀释至终浓度为0.5mg/ml。例如取20μl 25mg/ml蛋白标准,加入980μl稀释液即可配制成0.5mg/ml蛋白标准。蛋白样品在什么溶液中,标准品也宜用什么溶液稀释。但是为

了简便起见,也可以用0.9%NaCl或PBS稀释标准品。稀释后的0.5mg/ml蛋白标准可以-20℃长期保存。

2.BCA工作液的配制

根据样品数量,按50体积BCA试剂A加1体积BCA试剂B(50:1)配制适量BCA工作液,充分混匀。例如5mlBCA试剂A

加100μl BCA试剂B,混匀,配制成5.1ml BCA工作液。

BCA工作液室温24小时内稳定。

3.蛋白浓度检测

a.将标准品按0、1、2、4、8、12、16、20μl加到96孔板的标准品孔中,加标准品稀释液补足到20μl,相当于标准品浓度分别为0、0.025、0.05、0.1、0.2、0.3、0.4、0.5mg/ml。

b.加适当体积样品到96孔板的样品孔中。如果样品不足20μl,加标准品稀释液补足到20μl。请注意记录样品体积。

c.各孔加入200μl BCA工

作液,37℃放置20-30分钟。

注:也可以室温放置2小时,或60℃放置30分钟。BCA法测定蛋白浓度时,颜色会随着时间的延长不断加深。并且显色反应会因温

度升高而加快。如果浓度较低,适合在较高温度孵育,或适当延长孵育时间。

d.用酶标仪测定A562,或540-595nm之间的波长的吸光度。

e.根据标准曲线和使用的样品体积计算出样品的蛋白浓度。

常见问题:

1.测定标准曲线时发现随着标准品浓度的增加吸光度或颜色没有明显变化。

可能的原因是样品中含有严重干扰BCA法测定蛋白浓度的物质,详细的BCA法的兼容性列表请参考碧云天如下网页:http://www.beyotime.com/Compatibility

Chart For BCA Kit.pdf

2.是否每次测定时都需要做标准曲线?

建议每次测定时都做标准曲线。因为BCA法测定时颜色会随着时间的延长不断加深,并且显色反应的速度和温度有关,所以除非

精确控制显色反应的时间和温度,否则如需精确测定宜每次都做标准曲线。

相关产品:

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P0006

Bradford蛋白浓度测定试剂盒

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1ml

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BCA蛋白浓度测定试剂盒(增强型)

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说明书下载

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Inh ib ition of Polypeptide from Chlamys fa rreri on UVA2Induced Apoptosis of HaCaT Cells Depending on p38MAPK Pa thway and Ca spase23.

中国药科大学学报

2007 Jan ;42(2):116-120.

47. Wu ZQ, Chen J, Chi ZQ, Liu JG.

Involvement of dopamine system in regulation of Na+,K+-ATPase in the striatum upon activation of opioid receptors by morphine.

Mol Pharmacol

2007 Feb;71(2):519-30.

(IF 3.664)

48. Gao J, Zhao YN, Jiang QW.

Investigation of Asymptomatic Infection of Echovirus 30 in Population of Shanghai.

Journal of the virus

2007 March;23(2):121-124.

49. Zhang LF, Peng SQ, Wang S, Li BL, Han G, Dong YS.

Direct effects of lead (Pb2+) on the relaxation of in vitro cultured rat aorta to acetylcholine.

Toxicol Lett

2007 Apr 25;170(2):104-10.

(IF 3.569)

50. Deng XQ, Chen LL, Li NX.

The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats.

Liver Int

2007 Jun;27(5):708-15.

(IF 5.175)

51. Gao MQ, Guo SB, Chen XH, Du W, Wang CB.

Molecular mechanisms of polypeptide from Chlamys farreri protecting HaCaT cells from apoptosis induced by UVA plus UVB.

Acta Pharmacol Sin

2007 Jul;28(7):1007-14.

(IF 5.064)

52. Dong S, Li C, Wu P, Tsien JZ, Hu Y.

Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice.

Eur J Neurosci

2007 Jul;26(1):101-12.

(IF 3.115)

53. Wang Q, Liang C, Song J, Chen X.

HA2 from the Helicoverpa armigera nucleopolyhedrovirus: a WASP-related protein that activates Arp2/3-induced actin filament formation.

Virus Res

2007 Jul;127(1):81-7.

(IF 2.934)

54. Wang YC, Zou QM, Ren JM, Guo G, Xie QH, Liu j.

Study of the microspheres technology of Helicobacter pylori whole cell protein encapsulated by chitosan2alginate.

Journal of Chongqing Medical University 重庆医科大学学报

2007 July;36(13):1285-1287.

55. Li JL, Liu N, Chen XH, Sun M, Wang CB.

Inhibition of UVA-induced apoptotic signaling pathway by polypeptide from Chlamys farreri in human HaCaT keratinocytes.

RADIAT ENVIRON BIOPH

2007 Aug;46(3):263-8.

(IF 1.321)

56. Yuan QL, Yang CX, Xu P, Gao XQ, Deng L, Chen P, Sun ZL, Chen QY.

Neuroprotective effects of ginsenoside Rb1 on transient cerebral ischemia in rats.

Brain Res

2007 Sep 5;1167:1-12.

(IF 2.733)

57. Chen YR, Nie SD, Shan W, Jiang DJ, Shi RZ, Zhou Z, Guo R, Zhang Z, Li YJ.

Decrease in endogenous CGRP release in nitroglycerin tolerance: role of ALDH-2.

Eur J Pharmacol

2007 Sep 24;571(1):44-50.

(IF 3.263)

58. Zong-Chun Yi, Hong Wang, Guang-Yao Zhang, Bing Xia.

Downregulation of connexin 43 in nasopharyngeal carcinoma cells is related to promoter methylation.

Oral Oncol

2007 Oct;43(9):898-904.

(IF 3.979)

59. Wang ZL, Li JL, Wang CB.

The role of tumor necrosis factor rela ted apoptosis induc ing ligand and Polypeptide from Chlam ys fa rreri in UVA2induced apoptosis in HaCaT cells.

《中国药理学通报》

2007 Oct;23(10):1375-9.

60. Zhang Y, Zhen DX, Ren TL, Wang DP.

The Character istics Effects of Ga tifloxac in on L iverM icrosome Cytochrome P450 in Rats.

pharm j chin pla

2007 Dec;23(6):404-407.

61. Pan YQ, Ding D, Li DX, Chen SQ.

Expression and bioactivity analysis of Staphylococcal enterotoxin M and N.

PROTEIN EXPRES PURIF

2007 Dec;56(2):286-92.

(IF 1.513)

62. Nie H, Li Z, Lukas RJ, Shen Y, Song L, Wang X, Yin M.

Construction of SH-EP1-alpha4beta2-hAPP695 Cell Line and Effects of Nicotinic Agonists on beta-amyloid in the Cells.

Cell Mol Neurobiol

2008 Jan;28(1):103-12.

(IF 3.606)

63. Zhang DW, Cheng Y, Wang NL, Zhang JC, Yang MS, Yao XS.

Effects of total flavonoids and flavonol glycosides from Epimedium koreanum Nakai on the proliferation and differentiation of primary osteoblasts.

Phytomedicine

2008 Jan;15(1-2):55-61.

(IF 4.268)

64. Zhang H, Deng JY, Bi LJ, Zhou YF, Zhang ZP, Zhang CG, Zhang Y, Zhang XE.

Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase.

FEBS J

2008 Feb;275(4):753-62.

(IF 4.392)

65. Liu C, Wang Q, Guo H, Xia M, Yuan Q, Hu Y, Zhu H, Hou M, Ma J, Tang Z, Ling W.

Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine.

J Nutr

2008 Feb;138(2):311-5.

(IF 4.281)

66. Zhang GG, Bai YP, Chen MF, Shi RZ, Jiang DJ, Fu QM, Tan GS, Li YJ.

Asymmetric dimethylarginine induces TNF-alpha production via ROS/NF-kappaB dependent pathway in human monocytic cells and the inhibitory effect of reinioside C.

VASC PHARMACOL

2008 Feb-Mar;48(2-3):115-21.

(IF 4.152)

67. Yu S, Geng J, Zhou P, Wang J, Feng A, Chen X, Tong H, Hu J.

Application of a new hybrid organic-inorganic monolithic column for efficient deoxyribonucleic acid purification.

Anal Chim Acta

2008 Mar 24;611(2):173-81.

(IF 5.977)

68. Yu S, Geng J, Zhou P, Wang J, Chen X, Hu J.

New hydroxyapatite monolithic column for DNA extraction and its application in the purification of Bacillus subtilis crude lysate.

J Chromatogr A

2008 Mar 7;1183(1-2):29-37.

(IF 4.049)

69. Wang Y, Peng KM, Li JL, Song H, Li SH, Wei L, Wang JX.

Ultrastructure and melatonin 1a receptor distribution in the ovaries of African ostrich chicks.

Cytotechnology

2008 Mar;56(3):187-95.

(IF 1.777)

70. Zhang GG, Shi RZ, Jiang DJ, Chen YR, Jia-Chen, Tang ZY, Bai YP, Xiao HB, Li YJ.

Involvement of the endothelial DDAH/ADMA pathway in nitroglycerin tolerance: the role of ALDH-2.

Life Sci

2008 Mar 26;82(13-14):699-707.

(IF 3.647)

71. Li J, Liu W, Ding S, Xu W, Guan Y, Zhang JH, Sun X.

Hyperbaric oxygen preconditioning induces tolerance against brain ischemia-reperfusion injury by upregulation of antioxidant enzymes in rats.

Brain Res

2008 May 19;1210:223-9.

(IF 2.733)

72. Fu Y, Zhang Z, Zhang G, Liu Y, Cao Y, Yu J, Hu J, Yin X.

Adenovirus-mediated gene transfer of tissue factor pathway inhibitor induces apoptosis in vascular smooth muscle cells.

Apoptosis

2008 May;13(5):634-40.

(IF 4.543)

73. Tian B, Wang Z, Zhao Y, Wang D, Li Y, Ma L, Li X, Li J, Xiao N, Tian J, Rodriguez R.

Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model.

Cancer Lett

2008 Jun 18;264(2):299-308.

(IF 7.36)

74. Gao F, Wu DQ, Hu YH, Jin GX, Li GD, Sun TW, Li FJ.

In vitro cultivation of islet-like cell clusters from human umbilical cord blood-derived mesenchymal stem cells.

Transl Res

2008 Jun;151(6):293-302.

(IF 5.411)

75. He X, Zhang Z, Zhang H, Zhao Y, Chai Z.

Neurotoxicological evaluation of long-term lanthanum chloride exposure in rats.

Toxicol Sci

2008 Jun;103(2):354-61.

(IF 3.703)

76. Wan F, You J, Sun Y, Zhang XG, Cui FD, Du YZ, Yuan H, Hu FQ.

Studies on PEG-modified SLNs loading vinorelbine bitartrate (I): preparation and evaluation in vitro.

INT J PHARMACOL

2008 Jul 9;359(1-2):104-10.

(IF 0.692)

77. An R, Dong C, Lei Y, Han L, Li P, Chen J, Wang G, Shi Q, Gao C, Jiang H, Zhou W, Han J, Chu Y, Dong X.

PrP mutants with different numbers of octarepeat sequences are more susceptible to the oxidative stress.

SCI CHINA LIFE SCI

2008 Jul;51(7):630-9.

(IF 4.611)

78. Tian SL, Wang XY, Ding GH.

Repeated electro-acupuncture attenuates chronic visceral hypersensitivity and spinal cord NMDA receptor phosphorylation in a rat irritable bowel syndrome model.

Life Sci

2008 Aug 29;83(9-10):356-63.

(IF 3.647)

79. Chen M, Li Y, Yang T, Wang Y, Bai Y, Xie X.

ADMA induces monocyte adhesion via activation of chemokine receptors in cultured THP-1 cells.

Cytokine

2008 Aug;43(2):149-59.

(IF 2.952)

80. Wei Y, Weng D, Li F, Zou X, Young DO, Ji J, Shen P.

Involvement of JNK regulation in oxidative stress-mediated murine liver injury by microcystin-LR.

Apoptosis

2008 Aug;13(8):1031-42.

(IF 4.543)

81. Hu X, Zhou J, Zhang N, Tan H, Gao C.

Preparation and properties of an injectable scaffold of poly(lactic-co-glycolic acid) microparticles/chitosan hydrogel.

J MECH BEHAV BIOMED

2008 Oct;1(4):352-9.

(IF 3.372)

82. Zhu M, Gu F, Shi J, Hu J, Hu Y, Zhao Z.

Increased oxidative stress and astrogliosis responses in conditional double-knockout mice of Alzheimer-like presenilin-1 and presenilin-2.

FREE RADICAL BIO MED

2008 Nov 15;45(10):1493-9.

(IF 6.17)

83. Sun J, Wu Y, Wang J, Ma F, Liu X, Li Q.

Novel translationally controlled tumor protein homologue in the buccal gland secretion of Lampetra japonica.

Biochimie

2008 Nov-Dec;90(11-12):1760-8.

(IF 3.413)

84. Yi Q, Wen X, Li L, He B, Nie Y, Yao Wu Y, Zhang Z, Gu Z.

The chiral effects on the responses of osteoblastic cells to the polymeric substrates.

European Polymer Journal

2009;45:1970–8.

(IF 3.621)

85. ZHANG ZY, LIU XJ, LIU T, YAN L, WANG YJ, WANG CB.

Polypeptide from Chlamys farreri inhibits UVB-induced apoptosis of HaCaT cells via iNOS/NO and HSP90.

Chinese Journal of Oceanology and Limnology

2009;27(3):594-9.

(IF 0.741)

86. WU T, NAN KH, CHEN JD, JIN D, JIANG S, ZHAO PR, XU JC, DU H, ZHANG XQ, LI JW, PEI GX.

A new bone repair scaffold combined with chitosan/hydroxyapatite and sustained releasing icariin.

CHINESE SCI BULL

2009; 54(17):2953-2961.

(IF 1.649)

87. Liu XJ, Wang WC, Wang HJ, Zhang LL, Liu LQ, Wang YJ, Wang CB.

A polypeptide from Chlamys farreri inhibits UVB-induced HaCaT cells apoptosis via the Apaf-1/caspase-9 and Smac/XIAP signaling pathway.

Chinese Journal of Oceanology and Limnology

2009;27(3):587-93.

(IF 0.741)

88. Jin-qiao S, Bin S, Wen-hao Z, Yi Y.

Basic fibroblast growth factor stimulates the proliferation and differentiation of neural stem cells in neonatal rats after ischemic brain injury.

BRAIN DEV-JPN

2009;31(5):331-40.

(IF 1.504)

89. Yuan Q, Li PD, Li BH, Yang XZ, Xu SB, Liu XH, Zhou FX, Zhang WJ.

Differential IL-4/Stat6 activities correlate with differential expression of regulatory genes SOCS-1, SHP-1, and PP2A in colon cancer cells.

J CANCER RES CLIN

2009 Jan;135(1):131-40.

(IF 3.656)

90. Li W, Liu Y, Zhang JW, Ai CZ, Xiang N, Liu HX, Yang L.

Anti-androgen-independent prostate cancer effects of ginsenoside metabolites in vitro: mechanism and possible structure-activity relationship investigation.

Arch Pharm Res

2009 Jan;32(1):49-57.

(IF 2.934)

91. Wang YL, Wang CY, Zhang BJ, Zhang ZZ.

Shenfu injection suppresses apoptosis by regulation of Bcl-2 and caspase-3 during hypoxia/reoxygenation in neonatal rat cardiomyocytes in vitro.

Mol Biol Rep

2009 Feb;36(2):365-70.

(IF 1.402)

92. Liu XS, Jiang J, Jiao XY, Wu YE, Lin JH, Cai YM.

Lycorine induces apoptosis and down-regulation of Mcl-1 in human leukemia cells.

Cancer Lett

2009 Feb 8;274(1):16-24.

(IF 7.36)

93. Gao R, Wang J, Shen Y, Lei M, Wang Z.

Functional expression of voltage-gated sodium channels Nav1.5 in human breast caner cell line MDA-MB-231.

J HUAZHONG U SCI-MED

2009 Feb;29(1):64-7.

(IF 1.151)

94. Liu X, Zhang Z, Li P, Zhu L, Wang Y, Wang C.

Polypeptide from Chlamys farreri modulates UVB-induced activation of NF-kappaB signaling pathway and protection HaCaT cells from apoptosis.

REGUL PEPTIDES

2009 Feb 25;153(1-3):49-55.

(IF 1.813)

95. Jin D, Ojcius DM, Sun D, Dong H, Luo Y, Mao Y, Yan J.

Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways.

Infect Immun

2009 Feb;77(2):799-809.

(IF 3.201)

96. Kang Y, Hu M, Zhu Y, Gao X, Wang MW.

Antioxidative effect of the herbal remedy Qin Huo Yi Hao and its active component tetramethylpyrazine on high glucose-treated endothelial cells.

Life Sci

2009 Mar 27;84(13-14):428-36.

(IF 3.647)

97. Xu J, Wang S, Lin Y, Cao L, Wang R, Chi Z.

Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats.

Neurosci Lett

2009 Mar 27;453(1):58-61.

(IF 2.274)

98. Jia H, Qi X, Fang S, Jin Y, Han X, Wang Y, Wang A, Zhou H.

Carnosine inhibits high glucose-induced mesangial cell proliferation through mediating cell cycle progression.

REGUL PEPTIDES

2009 Apr 10;154(1-3):69-76.

(IF 1.813)

99. Zhang LF, Peng SQ, Wang S.

Decreased aortic contractile reaction to 5-hydroxytryptamine in rats with long-term hypertension induced by lead (Pb(2+)) exposure.

Toxicol Lett

2009 Apr 25;186(2):78-83.

(IF 3.569)

100. Dong C, Wang Y, Zhu YZ.

Asymmetric synthesis and biological evaluation of Danshensu derivatives as anti-myocardial ischemia drug candidates.

BIOORG MED CHEM LETT

2009 May 1;17(9):3499-507.

(IF 2.572)

101. Xiao X, Liu A, Wen H, Tian Y, Ni J, Liu G.

Expression and localization of transcription factor Ets-1 in the rat ovary during the estrous cycle and pregnancy.

Fertil Steril

2009 May;91(5 Suppl):1998-2005.

(IF 6.312)

102. Cheng B, Song J, Zou Y, Wang Q, Lei Y, Zhu C, Hu C.

Responses of vascular smooth muscle cells to estrogen are dependent on balance between ERK and p38 MAPK pathway activities.

Int J Cardiol

2009 May 29;134(3):356-65.

(IF 3.229)

103. Chen MF, Li YJ, Yang TL, Lou B, Xie XM.

Losartan inhibits monocytic adhesion induced by ADMA via downregulation of chemokine receptors in monocytes.

Eur J Clin Pharmacol

2009 May;65(5):457-64.

(IF 2.641)

104. Zhang DL, Chen YQ, Jiang X, Ji TT, Mei B.

Oxidative damage increased in presenilin1/presenilin2 conditional double knockout mice.

Neurosci Bull

2009 Jun;25(3):131-7.

(IF 4.326)

105. Wang XD, Meng MX, Gao LB, Liu T, Xu Q, Zeng S.

Permeation of astilbin and taxifolin in Caco-2 cell and their effects on the P-gp.

INT J PHARMACOL

2009 Aug 13;378(1-2):1-8.

(IF 0.692)

106. Chen B, Gao XQ, Yang CX, Tan SK, Sun ZL, Yan NH, Pang YG, Yuan M, Chen GJ, Xu GT, Zhang K, Yuan QL.

Neuroprotective effect of grafting GDNF gene-modified neural stem cells on cerebral ischemia in rats.

Brain Res

2009 Aug 11;1284:1-11.

(IF 2.733)

107. Ding D, Huang P, Sun H, Xue Q, Pan Y, Chen S.

Identification of protein components and quantitative immunoassay for SEC2 in staphylococcin injection.

J PHARMACEUT BIOMED

2009 Aug 15;50(1):79-85.

(IF 3.209)

108. Liu X, Shi S, Ye J, Liu L, Sun M, Wang C.

Effect of polypeptide from Chlamys farreri on UVB-induced ROS/NF-kappaB/COX-2 activation and apoptosis in HaCaT cells.

J PHOTOCH PHOTOBIO B

2009 Aug 3;96(2):109-16.

(IF 4.383)

109. Zhang Z, Wang Q, Li P, Zhou Y, Li S, Yi W, Chen A, Kong P, Hu C.

Overexpression of the Interferon regulatory factor 4-binding protein in human colorectal cancer and its clinical significance.

Cancer Epidemiol

2009 Aug;33(2):130-6.

(IF 2.179)

110. Ma K, Hu M, Qi Y, Qiu L, Jin Y, Yu J, Li B.

Structure-transfection activity relationships with glucocorticoid-polyethyl-enimine conjugate nuclear gene delivery systems.

Biomaterials

2009 Aug;30(22):3780-9.

(IF 10.317)

111. Liao Z, Huang C, Zhou F, Xiong J, Bao J, Zhang H, Sun W, Xie C, Zhou Y.

Radiation enhances suicide gene therapy in radioresistant laryngeal squamous cell carcinoma via activation of a tumor-specific promoter.

Cancer Lett

2009 Sep 28;283(1):20-8.

(IF 7.36)

112. Feng B, Huang CG, Chen RH, Guo YW, Jiao BH.

2'-Epi-2'-O-acetylthevetin B induces apoptosis partly via Ca(2+)-mediated mitochondrial pathway in human hepatocellular carcinoma HepG2 cells.

Cell Biol Int

2009 Sep;33(9):918-25.

(IF 2.571)

113. Ye Y, Hu SJ, Li L.

Inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced hypertrophic responses in rat neonatal cardiomyocytes: involvement of the RhoA/Rho kinase pathway.

FEBS Lett

2009 Sep 17;583(18):2997-3003.

(IF 3.057)

114. Shi GS, Ren LF, Wang LZ, Lin HS, Wang SB, Tong YQ.

H2O2/HCl and heat-treated Ti-6Al-4V stimulates pre-osteoblast proliferation and differentiation.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod

2009 Sep;108(3):368-75.

(IF 0.27)

115. Chen Y, Wang J, Yao Y, Yuan W, Kong M, Lin Y, Geng D, Nie R.

CRP regulates the expression and activity of tissue factor as well as tissue factor pathway inhibitor via NF-kappaB and ERK 1/2 MAPK pathway.

FEBS Lett

2009 Sep 3;583(17):2811-8.

(IF 3.057)

116. Chen WL, Qian Y, Meng WF, Pang JY, Lin YC, Guan YY, Chen SP, Liu J, Pei Z, Wang GL.

A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro.

Biochem Pharmacol

2009 Oct 15;78(8):941-50.

(IF 4.96)

117. Ma K, Hu MX, Qi Y, Zou JH, Qiu LY, Jin Y, Ying XY, Sun HY.

PAMAM-triamcinolone acetonide conjugate as a nucleus-targeting gene carrier for enhanced transfer activity.

Biomaterials

2009 Oct;30(30):6109-18.

(IF 10.317)

118. Hua W, Jiang J, Rong X, Wu R, Qiu H, Zhang Y, Chen Q.

The dual role of the cystathionine gamma-lyase/hydrogen sulfide pathway in CVB3-induced myocarditis in mice.

BIOCHEM BIOPH RES CO

2009 Oct 23;388(3):595-600.

(IF 2.985)

119. Lin Y, Chen Y, Yang X, Xu D, Liang S.

Proteome analysis of a single zebrafish embryo using three different digestion strategies coupled with liquid chromatography-tandem mass spectrometry.

Anal Biochem

2009 Nov 15;394(2):177-85.

(IF 2.877)

120. Xu Y, Ge R, Du J, Xin H, Yi T, Sheng J, Wang Y, Ling C.

Corosolic acid induces apoptosis through mitochondrial pathway and caspase activation in human cervix adenocarcinoma HeLa cells.

Cancer Lett

2009 Nov 1;284(2):229-37.

(IF 7.36)

121. Li H, Zhang L, Huang Q.

Differential expression of mitogen-activated protein kinase signaling pathway in the hippocampus of rats exposed to chronic unpredictable stress.

Behav Brain Res

2009 Dec 14;205(1):32-7.

(IF 2.977)

122. Gong HS, Meng XC, Wang H.

Plantaricin MG active against Gram-negative bacteria produced by Lactobacillus plantarum KLDS1.0391 isolated from"Jiaoke", a traditional fermented cream from China.

Food Control

2010;21:89–96.

(IF 4.258)

123. Li F, Gong QH, Wu Q, Lu YF, Shi JS.

Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats.

PHARMACOL BIOCHEM BE

2010;96(3):301-5.

(IF 2.519)

124. Li H, Fong C, Chen Y, Cai G, Yang M.

beta2- and beta3-, but not beta1-adrenergic receptors are involved in osteogenesis of mouse mesenchymal stem cells via cAMP/PKA signaling.

Arch Biochem Biophys

2010 15;496(2):77-83.

(IF 3.391)

125. Han J, Zhou YP, Jiang YZ, He YT, Mei F.

Postnatal development of interstitial cells of Cajal in mouse colon in response to Kit signal blockade with Imatinib (Glivec).

Acta Histochem

2010;112(3):215-21.

(IF 2.107)

126. Feng B, Guo YW, Huang CG, Li L, Chen RH, Jiao BH.

2'-epi-2'-O-Acetylthevetin B extracted from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.

CHEM-BIOL INTERACT

2010;183(1):142-53.

(IF 3.723)

127. Qin XL, Bi HC, Wang XD, Li JL, Wang Y, Xue XP, Chen X, Wang CX, Xu le J, Wang YT, Huang M.

Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506).

INT J PHARMACOL

2010;389(1-2):114-21.

(IF 0.692)

128. Lin Y, Xu J, Cao L, Han Y, Gao J, Xie N, Zhao X, Jiang H, Chi Z.

Mitochondrial base excision repair pathway failed to respond to status epilepticus induced by pilocarpine.

Neurosci Lett

2010;474(1):22-5.

(IF 2.274)

129. Li Q, Wu D, Zhang L, Zhang Y.

Effects of galantamine on β-amyloid release and beta-site cleaving enzyme 1 expression in differentiated human neuroblastoma SH-SY5Y cells.

Exp Gerontol

2010;45(11):842-7.

(IF 3.376)

130. Li GG, Liang XF, Xie Q, Li G, Yu Y, Lai K.

Gene structure, recombinant expression and functional characterization of grass carp leptin.

GEN COMP ENDOCR

2010;166(1):117-27.

(IF 2.426)

131. Zhao L, Wang X, Chang Q, Xu J, Huang Y, Guo Q, Zhang S, Wang W, Chen X, Wang J.

Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis.

Eur J Pharmacol

2010;627(1-3):304-12.

(IF 3.263)

132. He F, Zhang F, Yang G, Wang X, Zhao S.

Enhanced initial proliferation and differentiation of MC3T3-E1 cells on HF/HNO3 solution treated nanostructural titanium surface.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod

2010;110(4):e13-22.

(IF 0.27)

133. Yan J, Sun XB, Wang HQ, Zhao H, Zhao XY, Xu YX, Guo JC, Zhu CQ.

Chronic restraint stress alters the expression and distribution of phosphorylated tau and MAP2 in cortex and hippocampus of rat brain.

Brain Res

2010;1347:132-41.

(IF 2.733)

134. Song XZ, Xu JQ, Wang T, Liu FH.

Traditional Chinese medicine decoction enhances growth performance and intestinal glucose absorption in heat stressed pigs by up-regulating the expressions of SGLT1 and GLUT2 mRNA.

Livestock Science

2010;128:75–81.

(IF 1.376)

135. Yuan H, Zhang W, Du YZ, Hu FQ.

Ternary nanoparticles of anionic lipid nanoparticles/protamine/DNA for gene delivery.

INT J PHARMACOL

2010;392(1-2):224-31.

(IF 0.692)

136. Yu Q, Zhao Z, Sun J, Guo W, Fu J, Burnstock G, He C, Xiang Z.

Expression of P2X6 receptors in the enteric nervous system of the rat gastrointestinal tract.

Histochem Cell Biol

2010;133(2):177-88.

(IF 3.418)

137. Hu H, Zhang Y, Zou M, Yang S, Liang XQ.

Expression of TRF1, TRF2, TIN2, TERT, KU70, and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric cancer.

J CANCER RES CLIN

2010;136(9):1407-14.

(IF 3.656)

138. Ding XL, Wang YH, Ning LP, Zhang Y, Ge HY, Jiang H, Wang R, Yue SW.

Involvement of TRPV4-NO-cGMP-PKG pathways in the development of thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats.

Behav Brain Res

2010;208(1):194-201.

(IF 2.977)

139. Huang LH, Hu JQ, Tao WQ, Li YH, Li GM, Xie PY, Liu XS, Jiang J.

Gossypol inhibits phosphorylation of Bcl-2 in human leukemia HL-60 cells.

Eur J Pharmacol

2010;645(1-3):9-13.

(IF 3.263)

140. Sun J, Sha B, Zhou W, Yang Y.

VEGF-mediated angiogenesis stimulates neural stem cell proliferation and differentiation in the premature brain.

BIOCHEM BIOPH RES CO

2010;394(1):146-52.

(IF 2.985)

141. Mao Z, Wan L, Hu L, Ma L, Gao C.

Tat peptide mediated cellular uptake of SiO2 submicron particles.

COLLOID SURFACE B

2010;75(2):432-40.

(IF 4.389)

142. Liu PS, Chen Q, Wu SS, Shen J, Lin SC.

Surface modification of cellulose membranes with zwitterionic polymers for resistance to protein adsorption and platelet adhesion.

Journal of Membrane Science

2010;350:387–94.

(IF 7.015)

143. Cao BY, Yang YP, Luo WF, Mao CJ, Han R, Sun X, Cheng J, Liu CF.

Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway.

J Ethnopharmacol

2010;131(1):122-9.

(IF 3.69)

144. Liu J, Wang A, Li L, Huang Y, Xue P, Hao A.

Oxidative stress mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus.

SEIZURE-EUR J EPILEP

2010;19(3):165-72.

(IF 2.522)

145. Wu W, Yan C, Gan T, Chen Z, Lu X, Duerksen-Hughes PJ, Zhu X, Yang J.

Nuclear proteome analysis of cisplatin-treated HeLa cells.

MUTAT RES-REV MUTAT

2010;691(1-2):1-8.

(IF 5.803)

146. Zhou CL, Yu XJ, Chen LM, Jiang H, Li CY.

Corticotropin-releasing hormone attenuates vascular endothelial growth factor release from human HaCaT keratinocytes.

REGUL PEPTIDES

2010 Feb 25;160(1-3):115-20.

(IF 1.813)

147. Chen S, Chen Y, Hu C, Jing H, Cao Y, Liu X.

Association of clinicopathological features with UbcH10 expression in colorectal cancer.

J CANCER RES CLIN

2010 Mar;136(3):419-26.

(IF 3.656)

148. Sun J, Zhou W, Sha B, Yang Y.

Ischemia induced neural stem cell proliferation and differentiation in neonatal rat involved vascular endothelial growth factor and transforming growth factor-beta pathways.

BRAIN DEV-JPN

2010 Mar;32(3):191-200.

(IF 1.504)

149. Wu GJ, Zhou LZ, Wang KW, Chen F, Sun Y, Duan YR, Zhu YJ, Gu HC.

Hydroxylapatite nanorods: An efficient and promising carrier for gene transfection.

J COLLOID INTERF SCI

2010 May 15;345(2):427-32.

(IF 7.489)

150. Wang YX, Xu XY, Su WL, Wang Q, Zhu WX, Chen F, Jin G, Liu YJ, Li YD, Sun YP, Gao WC, Ruan CP.

Activation and Clinical Significance of p38 MAPK Signaling Pathway in Patients With Severe Trauma.

J Surg Res

2010 Jun 1;161(1):119-25.

(IF 1.841)

151. Yuan D, Pan Y, Zhang J, Shao C.

Role of nuclear factor-kappaB and P53 in radioadaptive response in Chang live cells.

MUTAT RES-REV MUTAT

2010 Jun 1;688(1-2):66-71.

(IF 5.803)

152. Zhang JC, Liu CL, Li YP, Sun J, Wang P, Di KQ, Chen H, Zhao YY .

Effect of yttrium ion on the proliferation, differentiation and mineralization function of primary mouse osteoblasts in vitro.

Journal Of Rare Earths

2010 Jun;28(3):466-470.

(IF 2.846)

153. Sun H, Li QW, Lv XY, Ai JZ, Yang QT, Duan JJ, Bian GH, Xiao Y, Wang YD, Zhang Z, Liu YH, Tan RZ, Yang Y, Wei YQ, Zhou Q.

MicroRNA-17 post-transcriptionally regulates polycystic kidney disease-2 gene and promotes cell proliferation.

Mol Biol Rep

2010 Jul;37(6):2951-8.

(IF 1.402)

154. Zhu J, Zhang L, Jin X, Han X, Sun C, Yan J.

beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway.

Mol Biol Rep

2010 Jul;37(6):2653-63.

(IF 1.402)

155. Wang S, Lv X, Zhang K, Lin T, Liu X, Yuan J, Dai Y, Li N.

Knockdown of the prion gene expression by RNA interference in bovine fibroblast cells.

Mol Biol Rep

2010 Oct;37(7):3193-8.

(IF 1.402)

156. Deng X, Cheng J, Zhang Y, Li N, Chen L.

Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats.

Acta Diabetol

2010 Dec;47(1):177-85.

(IF 3.418)

157. Wu J, Song R, Song W, Li Y, Zhang Q, Chen Y, Fu Y, Fang W, Wang J, Zhong Z, Ling H, Zhang L, Zhang F

Chlorpromazine protects against apoptosis induced by exogenous stimuli in the developing ratbrain.

PLoS One

2011;6(7):e21966.

(IF 2.74)

158. Huang Z, Song L, Wang C, Liu JQ, Chen C.

Hypoxia-ischemia upregulates TRAIL and TRAIL receptors in the immature rat brain.

DEV NEUROSCI-BASEL

2011;33(6):519-30.

(IF 3.041)

159. Wang S, Zhang J, Jiang T, Zheng L, Wang Z, Zhang J, Yu P.

Protective effect of Coenzyme Q(10) against oxidative damage in human lens epithelial cells by novel ocular drug carriers.

INT J PHARMACOL

2011;33(6):519-30.

(IF 0.692)

160. Lu J, Wang C, Zhou Z, Zhang Y, Cao T, Shi C, Chen Z, Chen L, Cai C, Fan X.

Immunogenicity and protective efficacy against murine tuberculosis ofa prime-boost regimenwith BCG and a DNA vaccine expressing ESAT-6 and Ag85A fusion protein.

CLIN DEV IMMUNOL

2011;2011:617892.

(IF 3.603)

161. Wang M, Yang J, Zhou Z, Qiu L, Wang L, Zhang H, Gao Y, Wang X, Zhang L, Zhao J, Song L

A primitive Toll-like receptor signaling pathway in mollusk Zhikong scallop Chlamys farreri.

Dev Comp Immunol

2011 Apr;35(4):511-20.

(IF 3.192)

162. Nie HZ, Li ZQ, Yan QX, Wang ZJ, Zhao WJ, Guo LC, Yin M.

Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-α4β2 nAChR-APP695 cells.

Neurochem Res

2011 May;36(5):904-12.

(IF 3.038)

163. Chen Z, Liu S, Sumida T, Sun S, Wei Y, Liu M, Dong Z, Zhang F, Hamakawa H, Wei F.

Silencing Id-1 with RNA Interference Inhibits Adenoid Cystic Carcinoma in Mice.

J Surg Res

2011 Jul;169(1):57-66.

(IF 1.841)

164. Cao B, Aa J, Wang G, Wu X, Liu L, Li M, Shi J, Wang X, Zhao C, Zheng T, Guo S, Duan J.

GC-TOFMS analysis of metabolites in adherent MDCK cells and a novel strategy for identifyingintracellular metabolic markers for use as cell amount indicators in data normalization.

Anal Bioanal Chem

2011 Jul;400(9):2983-93.

(IF 3.637)

165. Cao X, Yang M, Wei RC, Zeng Y, Gu JF, Huang WD, Yang DQ, Li HL, Ding M, Wei N, Zhang KJ, Xu B, Liu XR, Qian QJ, Liu XY.

Cancer targeting Gene-Viro-Therapy of liver carcinoma by dual-regulated oncolytic adenovirusarmed with TRAIL gene.

Gene Ther

2011 Aug;18(8):765-77.

(IF 4.128)

166. Hao D, Huang X, Zhen HY, Chen YC, Liu LJ, Wang XM, Wang ZY.

ER-a36 participate growth inhibiting which induced by Tamoxifen in gastric cancer cell line BGC823

Human Health and Biomedical Engineering (HHBE)

2011 Aug:1062-5.

167. Liu C, Guo W, Shi X, Kaium MA, Gu X, Zhu YZ.

Leonurine-cysteine analog conjugates as a new class of multifunctional anti-myocardial ischemia agent.

Eur J Med Chem

2011 Sep;46(9):3996-4009.

(IF 5.572)

168. Luo J, Xu Y, Zhu Q, Zhao F, Zhang Y, Peng X, Wang W, Wang X.

Expression pattern of Mical-1 in the temporal neocortex of patients with intractable temporalepilepsy and pilocarpine-induced rat model.

Synapse

2011 Nov;65(11):1213-21.

(IF 2.318)

169. Zhao L, Yang R, Cheng L, Wang M, Jiang Y, Wang S.

LPS-Induced Epithelial-Mesenchymal Transition of Intrahepatic Biliary Epithelial Cells.

J Surg Res

2011 Dec;171(2):819-25.

(IF 1.841)

170. Su TF, Zhang LH, Peng M, Wu CH, Pan W, Tian B, Shi J, Pan HL, Li M.

Cannabinoid CB2 receptors contribute to upregulation of β-endorphin in inflamed skin tissues byelectroacupuncture.

Mol Pain

2011 Dec 19;7:98.

(IF 2.696)

171. Ding M, Cao X, Xu HN, Fan JK, Huang HL, Yang DQ, Li YH, Wang J, Li R, Liu XY.

Prostate cancer-specific and potent antitumor effect of a DD3-controlled oncolytic virus harboring the PTEN gene.

PLoS One

2012;7(4):e35153.

(IF 2.74)

172. Guo E, He Q, Liu S, Tian L, Sheng Z, Peng Q, Guan J, Shi M, Li K, Gilbert LI, Wang J, Cao Y, Li S.

MET is required for the maximal action of 20-hydroxyecdysone during Bombyx metamorphosis.

PLoS One

2012;7(12):e53256.

(IF 2.74)

173. Liu Y, Yin B, Zhang C, Zhou L, Fan J.

Hsa-let-7a functions as a tumor suppressor in renal cell carcinoma cell lines by targeting c-myc.

BIOCHEM BIOPH RES CO

2012 Jan 6;417(1):371-5.

(IF 2.985)

174. Qiu T, Zhu HC, Liu XH, Dong WC, Weng XD, Hu CH, Kuang YL, Gao RH, Dan C, Tao T.

Lentiviral-mediated shRNA against RelB induces the generation of tolerogenic dendritic cells.

Int Immunopharmacol

2012 Mar;12(3):501-9.

(IF 3.943)

175. Xu JN, Chen JP, Chen DL.

Serodiagnosis efficacy and immunogenicity of the fusion protein of Mycobacterium tuberculosiscomposed of the 10-kilodalton culture filtrate protein, ESAT-6, and the extracellular domainfragment of PPE68.

Clin Vaccine Immunol

2012 Apr;19(4):536-44.

(IF 3.233)

176. Du Z, Yang Y, Hu Y, Sun Y, Zhang S, Peng W, Zhong Y, Huang X, Kong W.

A long-term high-fat diet increases oxidative stress, mitochondrial damage and apoptosis in theinner ear of D-galactose-induced aging rats.

HEARING RES

2012 May;287(1-2):15-24.

(IF 3.693)

177. Shi G, Chen X, Wang H, Wang S, Guo X, Zhang X.

Activity of sitafloxacin against extracellular and intracellular Staphylococcus aureus in vitro and invivo: comparison with levofloxacin and moxifloxacin.

J ANTIBIOT

2012 May;65(5):229-36.

(IF 2.668)

178. Xu JN, Yang ZW, Chen JP, Chen DL, Wang T, Liu MJ, Zhang L, Yang BB.

Protective immunity against Legionnaires' disease in an A/J mouse model using a DNA vaccinecomposed of an outer membrane protein (29 kDa) and the pilE fusion protein.

DIAGN MICR INFEC DIS

2012 May;73(1):9-15.

(IF 2.499)

179. Su TF, Zhao YQ, Zhang LH, Peng M, Wu CH, Pei L, Tian B, Zhang J, Shi J, Pan HL, Li M.

Electroacupuncture reduces the expression of proinflammatory cytokines in inflamed skin tissuesthrough activation of cannabinoid CB2 receptors.

Eur J Pain

2012 May;16(5):624-35.

(IF 3.492)

180. Zhang M, Dang L, Guo F, Wang X, Zhao W, Zhao R.

Coenzyme Q(10) enhances dermal elastin expression, inhibits IL-1α production and melanin synthesis in vitro.

INT J COSMETIC SCI

2012 Jun;34(3):273-9.

(IF 1.673)

181. Ding F, Shao ZW, Yang SH, Wu Q, Gao F, Xiong LM.

Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells.

Apoptosis

2012 Jun;17(6):579-90.

(IF 4.543)

182. Jin Y, Sui HJ, Dong Y, Ding Q, Qu WH, Yu SX, Jin YX.

Atorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating theAkt/mTOR and Akt/GSK-3β signaling pathways.

Acta Pharmacol Sin

2012 Jul;33(7):861-72.

(IF 5.064)

183. Luo J, Zeng K, Zhang C, Fang M, Zhang X, Zhu Q, Wang L, Wang W, Wang X, Chen G.

Down-Regulation of CRMP-1 in Patients with Epilepsy and a Rat Model.

Neurochem Res

2012 Jul;37(7):1381-91.

(IF 3.038)

184. Zhang D, Jin T, Xu YQ, Lu YF, Wu Q, Zhang YK, Liu J.

Diurnal-and sex-related difference of metallothionein expression in mice.

J Circadian Rhythms

2012 Jul 24;10(1):5.

(IF 2.31)

185. Mao J, Duan S, Song A, Cai Q, Deng X, Yang X.

Macroporous and Nanofribrous Poly (Lactide-co-Glycolide)(50/50) Scaffolds Via Phase Separation Combined with Particle-Leaching.

MAT SCI ENG C-MATER

2012 Aug 1;32(6):1407-1414.

(IF 5.88)

186. Du Z, Hu Y, Yang Y, Sun Y, Zhang S, Zhou T, Zeng L, Zhang W, Huang X, Kong W, Zhang H.

NADPH oxidase-dependent oxidative stress and mitochondrial damage in hippocampus of D-galactose-inducedaging rats.

J HUAZHONG U SCI-MED

2012 Aug;32(4):466-72.

(IF 1.151)

187. Wang F, Zhao XQ, Liu JN, Wang ZH, Wang XL, Hou XY, Liu R, Gao F, Zhang MX, Zhang Y, Bu PL.

Antagonist of microRNA-21 improves balloon injury-induced rat iliac artery remodeling by regulating proliferation and apoptosis of adventitial fibroblasts and myofibroblasts.

J Cell Biochem

2012 Sep;113(9):2989-3001.

(IF 4.237)

188. Zhou J, Shang J, Ping F, Zhao G.

Alcohol extract from Vernonia anthelmintica (L.) willd seed enhances melanin synthesis through activation of the p38 MAPK signaling pathway in B16F10 cells and primary melanocytes.

J Ethnopharmacol

2012 Sep 28;143(2):639-47.

(IF 3.69)

189. Huang H, Xiao T, He L, Ji H, Liu XY.

Interferon-β-armed oncolytic adenovirus induces both apoptosis and necroptosis in cancer cells.

ACTA BIOCH BIOPH SIN

2012 Sep;44(9):737-45.

(IF 2.836)

190. Xu Z, Zhang C, Zhang Y, Yang X.

Europium complexes as novel indicators of paracellular diffusion.

Chem Biodivers

2012 Sep;9(9):1916-22.

(IF 2.039)

191. Du G, Ye L, Zhang G, Dong Q, Liu K, Tian J.

Human IL18-IL2 fusion protein as a potential antitumor reagent by enhancing NK cell cytotoxicityand IFN-γ production.

J CANCER RES CLIN

2012 Oct;138(10):1727-36.

(IF 3.656)

192. Zhang YP, Sun P, Zhang XR, Yang WL.

In vitro gastric cancer cell imaging using near-infrared quantum dot-conjugated CC49.

Oncol Lett

2012 Nov;4(5):996-1002.

(IF 2.311)

193. Gao Y, Zhang RR, Li JH, Ren M, Ren ZX, Shi JH, Pan QZ, Ren SP.

Radix Astragali lowers kidney oxidative stress in diabetic rats treated with insulin.

Endocrine

2012 Dec;42(3):592-8.

(IF 3.235)

194. He Y, Cai G, Ni Y, Li Y, Zong H, He L.

siRNA-mediated knockdown of two tyrosinase genes from Schistosoma japonicum cultured in vitro.

Exp Parasitol

2012 Dec;132(4):394-402.

(IF 1.69)

195. Ye J, Yang T, Guo H, Tang Y, Deng F, Li Y, Xing Y, Yang L, Yang K.

Wnt10b promotes differentiation of mouse hair follicle melanocytes.

Int J Med Sci

2013;10(6):691-8.

(IF 2.523)

196. Liu Y, Wang DK, Jiang DZ, Qin X, Xie ZD, Wang QK, Liu M, Chen LM.

Cloning and functional characterization of novel variants and tissue-specific expression of alternative amino andcarboxyl termini of products of slc4a10.

PLoS One

2013;8(2):e55974.

(IF 2.74)

197. Feng J, Tang Y, Xu Y, Sun Q, Liao F, Han D.

Substrate stiffness influences the outcome of antitumor drug screening in vitro.

CLIN HEMORHEOL MICRO

2013 ;55(1):121-31.

(IF 1.741)

198. Liu C, Guo W, Maerz S, Gu X, Zhu Y.

3,5-Dimethoxy-4-(3-(2-carbonyl-ethyldisulfanyl)-propionyl)-benzoic acid 4-guanidino-butyl ester: a novel twin drug that prevents primary cardiac myocytes from hypoxia-induced apoptosis.

Eur J Pharmacol

2013 Jan 30;700(1-3):118-26.

(IF 3.263)

199. Wang G, Han B, Zhou H, Wu L, Wang Y, Jia G, Lv J, Cheng Z, Pan S, Liu J, Zhou Y, Sun B.

Inhibition of hydrogen sulfide synthesis provides protection for severe acute pancreatitis rats via apoptosispathway.

Apoptosis

2013 Jan;18(1):28-42.

(IF 4.543)

200. Liu Z, Zhang J, Huang X, Huang L, Li S, Wang Z.

Magnesium sulfate inhibits the secretion of high mobility group box 1 from lipopolysaccharide-activated RAW264.7 macrophages in vitro.

J Surg Res

2013 Jan;179(1):e189-195.

(IF 1.841)

201. Wu XR, Sha JJ, Liu DM, Chen YH, Yang GL, Zhang J, Chen YY, Bo JJ, Huang YR.

High expression of P53-induced Ring-h2 protein is associated with poor prognosis in clear cell renal cellcarcinoma.

EJSO-EUR J SURG ONC

2013 Jan;39(1):100-6.

(IF 3.959)

202. Wang Y, Fang J, Huang S, Chen L, Fan G, Wang C.

The chronic effects of low lead level on the expressions of Nrf2 and Mrp1 of the testes in the rats.

ENVIRON TOXICOL CHEM

2013 Jan;35(1):109-16.

(IF 3.152)

203. Yang F, Wang J, Hou J, Guo H, Liu C.

Bone regeneration using cell-mediated responsive degradable PEG-based scaffolds incorporating with rhBMP-2.

Biomaterials

2013 Feb;34(5):1514-28.

(IF 10.317)

204. Wang Z, Yan J, Zheng Q, Wang Z, Li J, Zhang X, Zhang S.

Effects of biodegradable Mg-6Zn alloy extracts on cell cycle of intestinal epithelial cells.

J Biomater Appl

2013 Feb;27(6):739-47.

(IF 2.22)

205. Li S, Tian H, Yue W, Li L, Gao C, Si L, Li W, Hu W, Qi L, Lu M.

Down-regulation of MTA1 protein leads to the inhibition of migration, invasion, and angiogenesis of non-small-celllung cancer cell line.

ACTA BIOCH BIOPH SIN

2013 Feb;45(2):115-22.

(IF 2.836)

206. Yang D, Li L, Liu H, Wu L, Luo Z, Li H, Zheng S, Gao H, Chu Y, Sun Y, Liu J, Jia L.

Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth ofliver cancer cells.

Cell Death Differ

2013 Feb;20(2):235-47.

(IF 10.717)

207. Zhou J, Shang J, Song J, Ping F.

Interleukin-18 augments growth ability of primary human melanocytes by PTEN inactivation through the AKT/NF-κB pathway.

INT J BIOCHEM CELL B

2013 Feb;45(2):308-16.

(IF 3.673)

208. Miao CG, Huang C, Huang Y, Yang YY, He X, Zhang L, Lv XW, Jin Y, Li J.

MeCP2 modulates the canonical Wnt pathway activation by targeting SFRP4 in rheumatoid arthritis fibroblast-likesynoviocytes in rats.

Cell Signal

2013 Mar;25(3):598-608.

(IF 3.968)

209. Liu Z, Chang Y, Zhang J, Huang X, Jiang J, Li S, Wang Z.

Magnesium deficiency promotes secretion of high-mobility group box 1 protein fromlipopolysaccharide-activated macrophages in vitro.

J Surg Res

2013 Apr;180(2):310-6.

(IF 1.841)

210. Wu J, Yang J, Liu Q, Wu S, Ma H, Cai Y.

Lanthanum induced primary neuronal apoptosis through mitochondrial dysfunction modulated by Ca2+ and Bcl-2 family.

Biol Trace Elem Res

2013 Apr;152(1):125-34.

(IF 2.639)

211. Li L, Ma Y.

Effect of fatty acids on the β-oxidation system and thioesterase of Lactococcus lactis subspecies lactis.

J Dairy Sci

2013 Apr;96(4):2003-10.

(IF 3.333)

212. Ren M, Yang S, Li J, Hu Y, Ren Z, Ren S.

Ginkgo biloba L.extract enhances the effectiveness of syngeneic bone marrow mesenchymal stem cells in lowering blood glucose levels and reversing oxidative stress.

Endocrine

2013 Apr;43(2):360-9.

(IF 3.235)

213. Qu J, Li J, Chen K, Qin D, Li K, Sheng Y, Zou C, Wang S, Huang A, Tang H.

Hepatitis B virus regulation of Raf1 promoter activity through activation of transcription factor AP-2α.

Arch Virol

2013 Apr;158(4):887-94.

(IF 2.243)

214. Cen J, Liu L, Li MS, He L, Wang LJ, Liu YQ, Liu M, Ji BS.

Alteration in P-glycoprotein at the blood-brain barrier in the early period of MCAO in rats.

J Pharm Pharmacol

2013 May;65(5):665-72.

(IF 2.571)

215. Chang Y, Huang X, Liu Z, Han G, Huang L, Xiong YC, Wang Z.

Dexmedetomidine inhibits the secretion of high mobility group box 1 from lipopolysaccharide-activated macrophages in vitro.

J Surg Res

2013 May;181(2):308-14.

(IF 1.841)

216. Jiang L, Zhang X, Zheng X, Ru A, Ni X, Wu Y, Tian N, Huang Y, Xue E, Wang X, Xu H.

Apoptosis, senescence, and autophagy in rat nucleus pulposus cells: Implications for diabetic intervertebral discdegeneration.

J Orthop Res

2013 May;31(5):692-702.

(IF 2.728)

217. Wang T, Huang Y, Zhang M, Wang L, Wang Y, Zhang L, Dong W, Chang P, Wang Z, Chen X, Tao L.

[Gly14]-Humanin offers neuroprotection through glycogen synthase kinase-3β inhibition in a mouse model ofintracerebral hemorrhage.

Behav Brain Res

2013 Jun 15;247:132-9.

(IF 2.977)

218. Xie W, Lin B, Zhou Z, Lu G, Lun J, Xia C, Li S, Hu Z.

Characterization of a novel β-agarase from an agar-degrading bacterium Catenovulumsp.X3.

APPL MICROBIOL BIOT

2013 Jun;97(11):4907-15.

(IF 3.53)

219. Wang M, Wang L, Zhou Z, Gao Y, Wang L, Shi X, Gai Y, Mu C, Song L.

The molecular characterization of a catalase from Chinese mitten crab Eriocheir sinensis.

Int J Immunogenet

2013 Jun;40(3):230-40.

(IF 1.13)

220. Zhang Y, Huang L, Bi H, Cui Y, Li J, Wang X, Qin X, Chen J, Huang M.

Study of the upregulation of the activity of cytochrome P450 3A isoforms by Astragalus injectionand Astragalus granules in rats and in cells.

EUR J DRUG METAB PH

2013 Jun;38(2):105-113.

(IF 1.913)

221. Sun L, Zhao M, Yu XJ, Wang H, He X, Liu JK, Zang WJ.

Cardioprotection by acetylcholine: a novel mechanism via mitochondrial biogenesis and function involving the PGC-1α pathway.

J Cell Physiol

2013 Jun;228(6):1238-48.

(IF 5.546)

222. Li X, Zhang J, Chen Z, Yang L, Xing X, Ma X, Yang Z.

Both PI3K- and mTOR-Signaling Pathways Take Part in CVB3-Induced Apoptosis of HeLa Cells.

DNA Cell Biol

2013 Jul;32(7):359-70.

(IF 3.191)

223. Jiang G, Cao Q, Li J, Zhang Y, Liu X, Wang Z, Guo F, Chen Y, Chen Y, Chen G, Wang X.

Altered expression of vesicular monoamine transporter 2 in epileptic patients and experimental rats.

Synapse

2013 Jul;67(7):415-26.

(IF 2.318)

224. Lin Z, Zhang Y, Li C, Qian H.

Purification antibody by thiophilic magnetic sorbent modified with 2-mercapto-1-methylimidazol.

COLLOID SURFACE B

2013 Aug 1;108:72-9.

(IF 4.389)

225. Wang F, Xu H, Yuan L, Ma S, Wang Y, Duan X, Duan J, Xiang Z, Xia Q.

An optimized sericin-1 expression system for mass-producing recombinant proteins in the middle silk glands oftransgenic silkworms.

Transgenic Res

2013 Oct;22(5):925-938.

(IF 1.856)

226. Li H, Jin G, Zhu P, Zou L, Shi J, Yi X, Zhang X, Tian M, Qin J.

Upregulation of Lhx8 increase VAChT expression and ACh release in neuronal cell line SHSY5Y.

Neurosci Lett

2014 Jan 24;559:184-8.

(IF 2.274)

227. Xiao X, Yu S, Li S, Wu J, Ma R, Cao H, Zhu Y, Feng J.

Exosomes: decreased sensitivity of lung cancer A549 cells to cisplatin.

PLoS One

2014 Feb 21;9(2):e89534.

(IF 2.74)

228. Liu Z, Zhang J, Wu L, Liu J, Zhang M.

Overexpression of GNAO1 correlates with poor prognosis in patients with gastric cancer and plays a role in gastric cancer cell proliferation and apoptosis.

Int J Mol Med

2014 Mar;33(3):589-96.

(IF 3.098)

229. Liu L, Wang P, Liu X, He D, Liang C, Yu Y.

Exogenous NAD+ supplementation protects H9c2 cardiac myoblasts against hypoxia/reoxygenation injury viaSirt1-p53 pathway.

FUND CLIN PHARMACOL

2014 Apr;28(2):180-189.

(IF 2.754)

230. Sheng Y, Ding S, Chen K, Chen J, Wang S, Zou C, Zhang J, Cao Y, Huang A, Tang H.

Functional analysis of miR-101-3p and Rap1b involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis.

Biochem Cell Biol

2014 Apr;92(2):152-62.

(IF 2.46)

231. Liu X, Gao Y, Yao H, Zhou L, Pei J, Sun L, Wang J, Sun D.

p38 and extracellular signal-regulated kinases activations have opposite effects on primary-cultured rat cerebellar granule neurons exposed to sodium arsenite.

J BIOCHEM MOL TOXIC

2014 Apr;28(4):143-8.

(IF 3.606)

232. Wang Y, Chen Z, Zhang Y, Fang S, Zeng Q.

Mitochondrial biogenesis of astrocytes is increased under experimental septic conditions.

CHINESE MED J-PEKING

2014 May;127(10):1837-42.

(IF 1.585)

233. Jin P, Wu H, Xu G, Zheng L, Zhao J.

Epigallocatechin-3-gallate (EGCG) as a pro-osteogenic agent to enhance osteogenic differentiation of mesenchymal stem cells from human bone marrow: an in vitro study.

Cell Tissue Res

2014 May;356(2):381-90.

(IF 4.044)

234. Shi Q, Cao J, Fang L, Zhao H, Liu Z, Ran J, Zheng X, Li X, Zhou Y, Ge D, Zhang H, Wang L, Ran Y, Fu J.

Geniposide suppresses LPS-induced nitric oxide, PGE2 and inflammatory cytokine by downregulating NF-κB, MAPK and AP-1 signaling pathways in macrophages.

Int Immunopharmacol

2014 Jun;20(2):298-306.

(IF 3.943)

235. Zhang LL, Sui HJ, Liang B, Wang HM, Qu WH, Yu SX, Jin Y.

Atorvastatin prevents amyloid-β peptide oligomer-induced synaptotoxicity and memory dysfunction in rats through a p38 MAPK-dependent pathway.

Acta Pharmacol Sin

2014 Jun;35(6):716-26.

(IF 5.064)

236. Liu L, Li T, Tan J, Fu J, Guo Q, Ji H, Zhang Y.

NG as a novel nitric oxide donor induces apoptosis by increasing reactive oxygen species and inhibiting mitochondrial function in MGC803 cells.

Int Immunopharmacol

2014 Aug 16;23(1):27-36.

(IF 3.943)

237. Wang X, Zou F, Deng H, Fu Z, Li Y, Wu L, Wang Z, Liu L.

Characterization of sphere forming cells with stem like properties from the gastric cancer cell lines MKN45 and SGC7901.

Mol Med Rep

2014 Dec;10(6):2937-41.

(IF 2.1)

238. Zuo T, Cao L, Sun X, Li X, Wu J, Lu S, Xue C, Tang Q.

Dietary squid ink polysaccharide could enhance SIgA secretion in chemotherapeutic mice.

Food Funct

2014 Dec;5(12):3189-3196.

(IF 4.171)

239. Yu C, Zhou Z, Wang J, Sun J, Liu W, Sun Y, Kong B, Yang H, Yang S.

In depth analysis of apoptosis induced by silica coated manganese oxide nanoparticles in vitro.

J Hazard Mater

2015;283:519-28.

(IF 9.038)

240. Shi Q, Cheng L, Liu Z, Hu K, Ran J, Ge D, Fu J.

The p38 MAPK inhibitor SB203580 differentially modulates LPS-induced interleukin 6 expression in macrophages.

Cent Eur J Immunol

2015;40(3):276-82.

(IF 1.415)

241. Yi X, Cai Y, Li W.

Isoflurane Damages the Developing Brain of Mice and Induces Subsequent Learning and Memory Deficits through FASL-FAS Signaling.

Biomed Res Int

2015;2015:315872.

(IF 2.276)

242. Jiang H, Xia Q, Xin S, Lun Y, Song J, Tang D, Liu X, Ren J, Duan Z, Zhang J.

Abnormal Epigenetic Modifications in Peripheral T Cells from Patients with Abdominal Aortic Aneurysm AreCorrelated with Disease Development.

J Vasc Res

2015;52(6):404-13.

(IF 1.725)

243. Yu L, Xie J, Xin N, Wang Z.

Panax notoginseng saponins promote wound repair of anterior cruciate ligament through phosphorylation of PI3K, AKT and ERK.

INT J CLIN EXP PATHO

2015 Jan 1;8(1):441-9.

(IF 0.252)

244. Yang S, Zheng J, Xiao X, Xu T, Tang W, Zhu H, Yang L, Zheng S, Dong K, Zhou G, Wang Y.

SOX2 promotes tumorigenicity and inhibits the differentiation of I-type neuroblastoma cells.

Int J Oncol

2015 Jan;46(1):317-23.

(IF 3.899)

245. Hao Z, Yang J, Wang C, Li Y, Zhang Y, Dong X, Zhou L, Liu J, Zhang Y, Qian J.

MicroRNA-7 inhibits metastasis and invasion through targeting focal adhesion kinase in cervical cancer.

Int J Clin Exp Med

2015 Jan 15;8(1):480-7.

(IF 0.166)

246. Du Z, Yang Q, Liu L, Li S, Zhao J, Hu J, Liu C, Qian D, Gao C.

NADPH oxidase 2-dependent oxidative stress, mitochondrial damage and apoptosis in the ventral cochlear nucleus of D-galactose-induced aging rats.

Neuroscience

2015 Feb 12;286:281-92.

(IF 3.056)

247. Xiao WJ, Ma T, Ge C, Xia WJ, Mao Y, Sun RB, Yu XY, Aa JY, Wang GJ.

Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextromethorphan in HepG2 cells.

Acta Pharmacol Sin

2015 Feb;36(2):259-67.

(IF 5.064)

248. Yu D, Li M, Tian Y, Liu J, Shang J.

Luteolin inhibits ROS-activated MAPK pathway in myocardial ischemia/reperfusion injury.

Life Sci

2015 Feb 1;122:15-25.

(IF 3.647)

249. Zhou J, Wang Z, Li Q, Liu F, Du Y, Yuan H, Hu F, Wei Y, You J.

Hybridized doxorubicin-Au nanospheres exhibit enhanced near-infrared surface plasmon absorption for photothermal therapy applications.

Nanoscale

2015 Mar 19;7(13):5869-83.

(IF 6.895)

250. Ren A, Qiu Y, Cui H, Fu G.

Inhibition of H3K9 methyltransferase G9a induces autophagy and apoptosis in oral squamous cell carcinoma.

BIOCHEM BIOPH RES CO

2015 Mar 27;459(1):10-7.

(IF 2.985)

251. Wang F, Meng Y, Zhang Y, Zhao G, Zheng X, Xiao Q, Yu Y.

Ketamine reduces lipopolysaccharide-induced high-mobility group box-1 through heme oxygenase-1 and nuclear factor erythroid 2-related factor 2/ p38 mitogen-activated protein kinase.

J Surg Res

2015 Apr;194(2):599-613.

(IF 1.841)

252. Yu S, Hou D, Chen P, Zhang Q, Lv B, Ma Y, Liu F, Liu H, Song EJ, Yang D, Liu J.

Adenosine induces apoptosis through TNFR1/RIPK1/P38 axis in colon cancer cells.

BIOCHEM BIOPH RES CO

2015 May 8;460(3):759-65.

(IF 2.985)

253. Zhang B, He P, Lu Y, Bian X, Yang X, Fu X, Wu Y, Li D.

HSF1 Relieves Amyloid-β-Induced Cardiomyocytes Apoptosis.

Cell Biochem Biophys

2015 Jun;72(2):579-87.

(IF 2.073)

254. Jia K, Zhang Y, Ma W, Zhang X, Sun Q.

Effect of interleukin-17 on receptor-interacting protein 4 expression and keratinocyte proliferation.

Exp Ther Med

2015 Jul;10(1):374-378.

(IF 1.785)

255. Guo X, Shang J, Deng Y, Yuan X, Zhu D, Liu H.

Alterations in left ventricular function during intermittent hypoxia: Possible involvement of O-GlcNAc protein and MAPK signaling.

Int J Mol Med

2015 Jul;36(1):150-8.

(IF 3.098)

256. Miao CG, Shi WJ, Xiong YY, Yu H, Zhang XL, Qin MS, Du CL, Song TW, Zhang B, Li J.

MicroRNA-663 activates the canonical Wnt signaling through the adenomatous polyposis coli suppression.

Immunol Lett

2015 Jul;166(1):45-54.

(IF 3.276)

257. Zhang Y, Wu S, Song S, Lv J, Feng C, Lin X.

Preparation and characterization of a stable BHK-21 cell line constitutively expressing the Schmallenberg virus nucleocapsid protein.

MOL CELL PROBE

2015 Aug;29(4):244-53.

(IF 1.951)

258. Wang C, Wu X, Shen F, Li Y, Zhang Y, Yu D.

Shlnc-EC6 regulates murine erythroid enucleation by Rac1-PIP5K pathway.

Dev Growth Differ

2015 Aug;57(6):466-73.

(IF 1.723)

259. Zhang F, Yang F, Zhao H, An Y.

Curcumin alleviates lung injury in diabetic rats by inhibiting NF-κB pathway.

CLIN EXP PHARMACOL P 

2015 Sep;42(9):956-63.

(IF 2.092)

260. Wang Y, Jiang Y, Ma N, Sang B, Hu X, Cong X, Liu Z.

Overexpression of Hiwi Inhibits the Growth and Migration of Chronic Myeloid Leukemia Cells.

Cell Biochem Biophys

2015 Sep;73(1):117-24.

(IF 2.073)

261. Wang Y, Jiang Y, Bian C, Dong Y, Ma C, Hu X, Liu Z.

Overexpression of Hiwi Inhibits the Cell Growth of Chronic Myeloid Leukemia K562 Cells and Enhances Their Chemosensitivity to Daunomycin.

Cell Biochem Biophys

2015 Sep;73(1):129-35.

(IF 2.073)

262. Wang H, Qi J, Li L, Wu T, Wang Y, Wang X, Ning Q.

Inhibitory effects of Chikusetsusaponin IVa on lipopolysaccharide-induced pro-inflammatory responses in THP-1 cells.

INT J IMMUNOPATH PH

2015 Sep;28(3):308-17.

(IF 2.209)

263. Miao CG, Qin D, Du CL, Ye H, Shi WJ, Xiong YY, Zhang XL, Yu H, Dou JF, Ma ST, Qin MS, Liu HZ, Fang YX, Zhou GL, Chen JZ, He X, Huang C, Huang Y, Zhang B, Song TW, Li J.

DNMT1 activates the canonical Wnt signaling in rheumatoid arthritis model rats via a crucial functional crosstalk between miR-152 and the DNMT, MeCP2.

Int Immunopharmacol

2015 Sep;28(1):344-53.

(IF 3.943)

264. Wu J, Cheng M, Liu Q, Yang J, Wu S, Lu X, Jin C, Ma H, Cai Y.

Protective Role of tert-Butylhydroquinone Against Sodium Fluoride-Induced Oxidative Stress and Apoptosis in PC12 Cells.

Cell Mol Neurobiol

2015 Oct;35(7):1017-25.

(IF 3.606)

265. Wang G, Kang N, Gong H, Luo Y, Bai C, Chen Y, Ji X, Huang C, Dong Q.

Upregulation of uncoupling protein Ucp2 through acute cold exposure increases post-thaw sperm quality in zebrafish.

Cryobiology

2015 Dec;17(3):646-71.

(IF 2.283)

266. Chen L, Mao F, Kirumba GC, Jiang C, Manefield M, He Y.

Changes in metabolites, antioxidant system, and gene expression in Microcystis aeruginosa under sodium chloride stress.

ECOTOX ENVIRON SAFE

2015 Dec;122:126-35.

(IF 4.872)

267. Chen D, Tao X, Wang Y, Tian F, Wei Y, Chen G, Shen H, Wang Z, Yu Z, Li H, Chen G.

Curcumin accelerates reendothelialization and ameliorates intimal hyperplasia in balloon-injured rat carotid artery via the upregulation of endothelial cell autophagy.

Int J Mol Med

2015 Dec;36(6):1563-71.

(IF 3.098)

268. Wang W, Zeng L, Wang ZM, Zhang S, Rong XF, Li RH.

Ginsenoside Rb1 inhibits matrix metalloproteinase 13 through down-regulating Notch signaling pathway in osteoarthritis.

EXP BIOL MED

2015 Dec;240(12):1614-21.

(IF 3.139)

269. Li L, Yang C, Liu X, Yang S, Ye S, Jia J, Liu W, Zhang Y.

Elevated expression of microRNA-30b in osteoarthritis and its role in ERG regulation of chondrocyte.

Biomed Pharmacother

2015 Dec;76:94-9.

(IF 4.545)

270. Wang D, Wang Y, Xu S, Wang F, Wang B, Han K, Sun D, Li L.

Epigallocatechin-3-gallate Protects against Hydrogen Peroxide-Induced Inhibition of OsteogenicDifferentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells.

Stem Cells Int

2016;2016:7532798.

(IF 3.869)

271. Zhang L, Zhao X, Wang F, Lin Q, Wang W.

Effects of Morinda officinalis Polysaccharide on Experimental Varicocele Rats.

EVID-BASED COMPL ALT

2016;2016:5365291.

(IF 1.813)

272. Yan X, Liu J, Wu H, Liu Y, Zheng S, Zhang C, Yang C.

Impact of miR-208 and its Target Gene Nemo-Like Kinase on the Protective Effect of Ginsenoside Rb1 inHypoxia/Ischemia Injuried Cardiomyocytes.

CELL PHYSIOL BIOCHEM

2016;39(3):1187-95.

(IF 5.5)

273. Kang X, Yang Y, Jiao Y, Song H, Song L, Xiong D, Wu L, Pan Z, Jiao X.

HA1-2-fljB Vaccine Induces Immune Responses against Pandemic Swine-Origin H1N1 Influenza Virus inMice.

J MOL MICROB BIOTECH

2016;26(6):422-432.

(IF 0.803)

274. Yuan Y, Li D, Li H, Wang L, Tian G, Dong Y.

YAP overexpression promotes the epithelial-mesenchymal transition and chemoresistance in pancreatic cancer cells.

Mol Med Rep

2016 Jan;13(1):237-42.

(IF 2.1)

275. Cheng S, Liang X, Wang Y, Jiang Z, Liu Y, Hou W, Li S, Zhang J, Wang Z.

The circadian Clock gene regulates acrosin activity of sperm through serine protease inhibitor A3K.

EXP BIOL MED

2016 Jan;241(2):205-15.

(IF 3.139)

276. Liu J, Tang X, Wang Y, Zang Y, Zhou B.

A Zostera marina manganese superoxide dismutase gene involved in the responses to temperature stress.

Gene

2016 Jan 10;575(2 Pt 3):718-24.

(IF 2.984)

277. Wu ZB, Cai L, Lin SJ, Leng ZG, Guo YH, Yang WL, Chu YW, Yang SH, Zhao WG.

Heat Shock Protein 47 Promotes Glioma Angiogenesis.

Brain Pathol

2016 Jan;26(1):31-42.

(IF 5.568)

278. Ding W, Tong Y, Zhang X, Pan M, Chen S.

Study of Arsenic Sulfide in Solid Tumor Cells Reveals Regulation of Nuclear Factors of Activated T-cells byPML and p53.

SCI REP-UK

2016 Jan 22;6:19793.

(IF 3.998)

279. Yuan Y, Li D, Li H, Wang L, Tian G, Dong Y.

YAP overexpression promotes the epithelial-mesenchymal transition and chemoresistance in pancreaticcancer cells.

Mol Med Rep

2016 Jan;13(1):237-42.

(IF 2.1)

280. Chen Y, Jiang T, Shi L, He K.

hcrcn81 promotes cell proliferation through Wnt signaling pathway in colorectal cancer.

Med Oncol

2016 Jan;33(1):3.

(IF 2.834)

281. Sheng Y, Wang H, Liu D, Zhang C, Deng Y, Yang F, Zhang T, Zhang C.

Methylation of tumor suppressor gene CDH13 and SHP1 promoters and their epigenetic regulation by theUHRF1/PRMT5 complex in endometrial carcinoma.

Gynecol Oncol

2016 Jan;140(1):145-51.

(IF 4.623)

282. Yang J, Ma Q, Zhang Y, Wang X, Zhang G, Ma Z.

Molecular cloning and functional analysis of GbRVd, a gene in Gossypium barbadense that plays animportant role in conferring resistance to Verticillium wilt.

Gene

2016 Jan 10;575(2 Pt 3):687-94.

(IF 2.984)

283. Zhou Y, Yang Q, Xu H, Zhang J, Deng H, Gao H, Yang J, Zhao D, Liu F.

miRNA-221-3p Enhances the Secretion of Interleukin-4 in Mast Cells through the Phosphatase and TensinHomolog/p38/Nuclear Factor-kappaB Pathway.

PLoS One

2016 Feb 22;11(2):e0148821.

(IF 2.74)

284. Zhou L, Jiang L, Xu M, Liu Q, Gao N, Li P, Liu EH.

Miltirone exhibits antileukemic activity by ROS-mediated endoplasmic reticulum stress and mitochondrialdysfunction pathways.

SCI REP-UK

2016 Feb 5;6:20585.

(IF 3.998)

285. Gong Y, Li H, Li Y.

Effects of Bacillus subtilis on Epithelial Tight Junctions of Mice with Inflammatory Bowel Disease.

J INTERF CYTOK RES

2016 Feb;36(2):75-85.

(IF 2.032)

286. Li Y, Zhu J, Liu Y, Chen X, Lei S, Li L, Jiang B, Tan L, Yu S, Zhao Y.

Glycogen Synthase Kinase 3β Influences Injury Following Cerebral Ischemia/Reperfusion in Rats.

Int J Biol Sci

2016 Feb 29;12(5):518-31.

(IF 4.858)

287. Ma WY, Jia K, Zhang Y.

IL-17 promotes keratinocyte proliferation via the downregulation of C/EBPα.

Exp Ther Med

2016 Feb;11(2):631-636.

(IF 1.785)

288. Tang Y, Lu S, Gan X, Liu F, Zhang Y, Luo C, Pan Y, Hong L, Gan R.

Expression of LMP and EBNA genes in Epstein-Barr virus-associated lymphomas in Hu-PBL/SCID mice.

Oncol Rep

2016 Feb;35(2):905-11.

(IF 3.417)

289. Ma J. Wang Z, Liu C, Shen H, Chen Z, Yin J, Zuo G, Duan X, Li H, Chen G.

Pramipexole-Induced Hypothermia Reduces Early Brain Injury via PI3K/AKT/GSK3β pathway inSubarachnoid Hemorrhage rats.

SCI REP-UK

2016 Mar 30;6:23817.

(IF 3.998)

290. Wang W, Wang X, Chen L, Zhang Y, Xu Z, Liu J, Jiang G, Li J, Zhang X, Wang K, Wang J, Chen G, Luo J.

The microRNA miR-124 suppresses seizure activity and regulates CREB1 activity.

Expert Rev Mol Med

2016 Mar 21;18:e4.

(IF 3.875)

291. Ma Y, Wang H, Yan D, Wei Y, Cao Y, Yi P, Zhang H, Deng Z, Dai J, Liu X, Luo J, Zhang Z, Sun S, Guo H.

Magnetic Resonance Imaging Revealed Splenic Targeting of Canine Parvovirus Capsid Protein VP2.

SCI REP-UK

2016 Mar 21;6:23392.

(IF 3.998)

292. Liu L, Wang D, Wang J, Wang S.

The Nitric Oxide Prodrug JS-K Induces Ca2+ -Mediated Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells.

J BIOCHEM MOL TOXIC

2016 Apr;30(4):192-9.

(IF 3.606)

293. Dan Yue, Zhang Y, Cheng L, Ma J, Xi Y, Yang L, Su C, Shao B, Huang A, Xiang R, Cheng P.

Hepatitis B virus X protein (HBx)-induced abnormalities of nucleic acid metabolism revealed by (1)H-NMR-based metabonomics.

SCI REP-UK

2016 Apr 14;6:24430.

(IF 3.998)

294. Shang J, Yao Y, Fan X, Shangguan L, Li J, Liu H, Zhou Y.

miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53-p21and p16-pRB pathways.

BBA-BIOMEMBRANES

2016 Apr;1863(4):520-32.

(IF 3.411)

295. Song Zh, Tong G, Xiao K, Jiao le F, Ke Y, Hu Ch.

L-cysteine protects intestinal integrity, attenuates intestinal inflammation and oxidant stress, andmodulates NF-κB and Nrf2 pathways in weaned piglets after LPS challenge.

INNATE IMMUN-LONDON

2016 Apr;22(3):152-61.

(IF 2.298)

296. Ye H, Wu Q, Guo M, Wu K, Lv Y, Yu F, Liu Y, Gao X, Zhu Y, Cui L, Liang N, Yun T, Li L, Zheng X.

Growth inhibition effects of ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid on colorectal

Mol Med Rep

2016 Apr;13(4):3525-32.

(IF 2.1)

297. Tian W, Xiong J, Zhu S, Xu D, Shen H, Deng Y.

mTOR signaling pathway is inhibited downstream of the cyclophilin D-mediated mitochondrial permeabilitytransition in honokiol-triggered regulated necrosis.

Mol Med Rep

2016 Apr;13(4):3227-35.

(IF 2.1)

298. Zhang B, Qiangba Y, Shang P, Lu Y, Yang Y, Wang Z, Zhang H.

Gene expression of vascular endothelial growth factor A and hypoxic adaptation in Tibetan pig.

J ANIM SCI BIOTECHNO

2016 Apr 2;7:21.

(IF 4.167)

299. Jiang X, Chen HQ, Cui ZH, Yin L, Zhang WL, Liu WB, Han F, Ao L, Cao J, Liu JY.

Low-dose and combined effects of oral exposure to bisphenol A and diethylstilbestrol on the malereproductive system in adult Sprague-Dawley rats.

ENVIRON TOXICOL CHEM

2016 Apr;43:94-102.

(IF 3.152)

300. Shi H, Xu J, Zhao R, Wu H, Gu L, Chen Y.

FGF2 regulates proliferation, migration, and invasion of ECA109 cells through PI3K/Akt signalling pathwayin vitro.

Cell Biol Int

2016 May;40(5):524-33.

(IF 2.571)

301. Xie X, Han M, Zhang L, Liu L, Gu Z, Yang M, Yang H.

Effects of Mycobacterium tuberculosis ESAT6-CFP10 Protein on Cell Viability and Production of Nitric Oxidein Alveolar Macrophages.

JUNDISHAPUR J MICROB

2016 May 30;9(6):e33264.

(IF 0.593)

302. Shen SH, Yu N, Xu H, Liu XY, Tan GW, Wang ZX.

Inhibition of Human Glioma Cell Proliferation Caused by Knockdown of Utrophin Using a Lentivirus-Mediated System.

CANCER BIOTHER RADIO

2016 May;31(4):133-8.

(IF 2.314)

303. Zhang C, Wang Z, Zhao J, Li Q, Huang C, Zhu L, Lu D.

Neuroprotective Effect of Lutein on NMDA-Induced Retinal Ganglion Cell Injury in Rat Retina.

Cell Mol Neurobiol

2016 May;36(4):531-40.

(IF 3.606)

304. Wu X, Qi X, Lu Y, Lin C, Yuan Y, Zhu Q, Yin Q, Li W, Li Y, Bian H.

Liguzinediol protects against cardiac fibrosis in rats in vivo and in vitro.

Biomed Pharmacother

2016 May;80:260-7.

(IF 4.545)

305. Zhang B, Shang P, Qiangba Y, Xu A, Wang Z, Zhang H.

The association of NR1H3 gene with lipid deposition in the pig.

Lipids Health Dis

2016 May 26;15:99.

(IF 2.906)

306. Yin J, Li H, Meng C, Chen D, Chen Z, Wang Y, Wang Z, Chen G.

Inhibitory effects of omega-3 fatty acids on early brain injury after subarachnoid hemorrhage in rats:Possible involvement of G protein-coupled receptor 120/β-arrestin2/TGF-β activated kinase-1 bindingprotein-1 signaling pathway.

INT J BIOCHEM CELL B

2016 Jun;75:11-22.

(IF 3.673)

307. Shi Z, Wu D, Tang R, Li X, Chen R, Xue S, Zhang C, Sun X.

Silencing of HMGA2 promotes apoptosis and inhibits migration and invasion of prostate cancer cells.

J BIOSCI BIOENG

2016 Jun;41(2):229-36.

(IF 2.366)

308. Zhu Y, 2 Cui H, Xia Y, Gan H1.

RIPK3-Mediated Necroptosis and Apoptosis Contributes to Renal Tubular Cell Progressive Loss andChronic Kidney Disease Progression in Rats.

PLoS One

2016 Jun 9;11(6):e0156729.

(IF 2.74)

309. Shen X, Ma L, Dong W, Wu Q, Gao Y, Luo C, Zhang M, Chen X, Tao L.

Autophagy regulates intracerebral hemorrhage induced neural damage via apoptosis and NF-κB pathway.

Neurochem Int

2016 Jun;96:100-12.

(IF 3.881)

310. Ye MH, Nan YL, Ding MM, Hu JB, Liu Q, Wei WH, Yang SM.

Effects of dietary tannic acid on the growth, hepatic gene expression, and antioxidant enzyme activity inBrandt's voles (Microtus brandti).

COMP BIOCHEM PHYS B

2016 Jun-Jul;196-197:19-26.

(IF 2.219)

311. Sun L, Dong Y, Zhao J, Yin Y, Zheng Y.

The CLC-2 Chloride Channel Modulates ECM Synthesis, Differentiation, and Migration of HumanConjunctival Fibroblasts via the PI3K/Akt Signaling Pathway.

Int J Mol Sci

2016 Jun 9;17(6). pii: E910.

(IF 4.556)

312. He M, Wang M, Huang Y, Peng W, Zheng Z, Xia N, Xu J, Tian D.

The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADDand RIP1.

SCI REP-UK

2016 Jun 8;6:27597.

(IF 3.998)

313. Cai L, Leng ZG, Guo YH, Lin SJ, Wu ZR, Su ZP, Lu JL, Wei LF, Zhuge QC, Jin K, Wu ZB.

Dopamine agonist resistance-related endocan promotes angiogenesis and cells viability of prolactinomas.

Endocrine

2016 Jun;52(3):641-51.

(IF 3.235)

314. Zhu MY, Lin D, Liu J, Mo HY.

Artesunate interfere in modulation of Foxp3 expression in synovial cells in collagen-induced arthritis rats.

Chin J Integr Med

2016 Jun 28.[Epub ahead of print]

(IF 1.545)

315. Gao H, Deng H, Xu H, Yang Q, Zhou Y, Zhang J, Zhao D, Liu F.

MicroRNA-223 promotes mast cell apoptosis by targeting the insulin-like growth factor 1 receptor.

Exp Ther Med

2016 Jun;11(6):2171-2176.

(IF 1.785)

316. Zhang H, Song Y, Li Z, Zhang T, Zeng L.

Evaluation of breviscapine on prevention of experimentally induced abdominal adhesions in rats.

Am J Surg

2016 Jun;211(6):1143-52.

(IF 2.125)

317. Geng F, Huang X, Ma M.

Hen Egg White Ovomacroglobulin Promotes Fibroblast Migration via Mediating Cell Adhesion and Cytoskeleton.

J SCI FOOD AGR

2016 Jul;96(9):3188-94.

(IF 2.614)

318. Xue F, Zhu L, Meng QW, Wang L, Chen XS, Zhao YB, Xing Y, Wang XY, Cai L.

FAT10 is associated with the malignancy and drug resistance of non-small-cell lung cancer.

ONCOTARGETS THER

2016 Jul 19;9:4397-409.

(IF 3.337)

319. Wang Y, Mei X, Yuan J, Lai X, Xu D.

Taurine zinc solid dispersions enhance bile-incubated L02 cell viability and improve liver function byinhibiting ERK2 and JNK phosphorylation during cholestasis.

Toxicology

2016 Jul 29;366-367:10-9.

(IF 4.099)

320. Liu Z, Ma C, Shen J, Wang D, Hao J, Hu Z.

SDF 1/CXCR4 axis induces apoptosis of human degenerative nucleus pulposus cells via the NF κBpathway.

Mol Med Rep

2016 Jul;14(1):783-9.

(IF 2.1)

321. Ma L, Shen X, Gao Y, Wu Q, Ji M, Luo C, Zhang M, Wang T, Chen X, Tao L.

Blocking B7-1/CD28 Pathway Diminished Long-Range Brain Damage by Regulating the Immune andInflammatory Responses in a Mouse Model of Intracerebral Hemorrhage.

Neurochem Res

2016 Jul;41(7):1673-83.

(IF 3.038)

322. Gao Y, Ma L, Luo CL, Wang T, Zhang MY, Shen X, Meng HH, Ji MM, Wang ZF, Chen XP, Tao LY.

IL-33 Exerts Neuroprotective Effect in Mice Intracerebral Hemorrhage Model Through SuppressingInflammation/Apoptotic/Autophagic Pathway.

Mol Neurobiol

2016 Jul 12. [Epub ahead of print]

(IF 4.5)

323. Wu F, Shi W, Zhou G, Yao H, Xu C, Xiao W, Wu J, Wu X.

Ginkgolide B functions as a determinant constituent of Ginkgolides in alleviating lipopolysaccharide-induced lung injury.

Biomed Pharmacother

2016 Jul;81:71-8.

(IF 4.545)

324. Zhang Q, Zhao Y, Xu Y, Chen Z, Liu N, Ke C, Liu B, Wu W.

Sodium ferulate and n-butylidenephthalate combined with bone marrow stromal cells (BMSCs) improve thetherapeutic effects of angiogenesis and neurogenesis after rat focal cerebral ischemia.

J Transl Med

2016 Jul 28;14(1):223.

(IF 4.124)

325. Gao F, Zhang LH, Su TF, Li L, Zhou R, Peng M, Wu CH, Yuan XC, Sun N, Meng XF, Tian B, Shi J, Pan HL, Li M.

Signaling Mechanism of Cannabinoid Receptor-2 Activation-Induced β-Endorphin Release.

Mol Neurobiol

2016 Aug;53(6):3616-25.

(IF 4.5)

326. Liang Y, Ji J, Lin Y, He Y, Liu J.

The Ganglioside GM-1 Inhibits Bupivacaine-Induced Neurotoxicity in Mouse Neuroblastoma Neuro2a Cells.

Cell Biochem Funct

2016 Aug;34(6):455-62.

(IF 2.632)

327. Cui Y, Duan X, Li H, Dang B, Yin J, Wang Y, Gao A, Yu Z, Chen G.

Hydrogen Sulfide Ameliorates Early Brain Injury Following Subarachnoid Hemorrhage in Rats.

Mol Neurobiol

2016 Aug;53(6):3646-57.

(IF 4.5)

328. Yu J, Qiu Y, Yang J, Bian S, Chen G, Deng M, Kang H, Huang L.

DNMT1-PPARγ pathway in macrophages regulates chronic inflammation and atherosclerosis developmentin mice.

SCI REP-UK

2016 Aug 17;6:30053.

(IF 3.998)

329. Wang C, Zhang Y, Zhan Y, Luo C, Li Y, Qiu D, Mu D, Duan H, Zhou K, Hua Y.

The effect of 17α-ethynylestradiol induced intrahepatic cholestasis of pregnancy on placental P-glycoprotein in mice: Implications in the individualized transplacental digoxin treatment for fetal heartfailure.

Placenta

2016 Aug;44:91-7.

(IF 3.177)

330. Guo C, Yang L, Luo J, Zhang C, Xia Y, Ma T, Kong L.

Sophoraflavanone G from Sophora alopecuroides inhibits lipopolysaccharide-induced inflammation inRAW264.7 cells by targeting PI3K/Akt, JAK/STAT and Nrf2/HO-1 pathways.

Int Immunopharmacol

2016 Sep;38:349-56.

(IF 3.943)

331. Xu Y, Xiang J, Zhao H, Liang H, Huang J, Li Y, Pan J, Zhou H, Zhang X, Wang JH, Liu Z, Wang J.

Human amniotic fluid stem cells labeled with up-conversion nanoparticles for imaging-monitored repairingof acute lung injury.

Biomaterials

2016 Sep;100:91-100.

(IF 10.317)

332. Wang C, Duan X, Sun X, Liu Z, Sun P, Yang X, Sun H, Liu K, Meng Q.

Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholicsteatohepatitis in mice.

Food Funct

2016 Sep 14;7(9):3716-23.

(IF 4.171)

333. Meng Q, Shao L, Luo X, Mu Y, Xu W, Gao L, Xu H, Cui Y.

Expressions of VEGF-A and VEGFR-2 in placentae from GDM pregnancies.

REPROD BIOL ENDOCRIN

2016 Sep 20;14(1):61.

(IF 3.235)

334. Shen M, Fan D, Zang Y, Chen Y, Zhu K, Cai Z, Liu Y, Sun X, Liu J, Gong J.

Neuroprotective effects of methane-rich saline on experimental acute carbon monoxide toxicity.

J Neurol Sci

2016 Oct 15;369:361-7.

(IF 3.115)

335. Deheng C, Kailiang Z, Weidong W, Haiming J, Daoliang X, Ningyu C, Huazi X.

Salidroside Promotes Random Skin Flap Survival in Rats by Enhancing Angiogenesis and InhibitingApoptosis.

J Reconstr Microsurg

2016 Oct;32(8):580-586.

(IF 1.841)

336. Zhang K, Zhu X, Lu Y.

Effect of Mild Heating on Human Lens Epithelial Cells: A Possible Model of Lens Aging.

SCI REP-UK

2016 Oct 11;6:33917.

(IF 3.998)

337. Ge H, Yu A, Chen J, Yuan J, Yin Y, Duanmu W, Tan L, Yang Y, Lan C, Chen W, Feng H, Hu R.

Poly-L-ornithine enhances migration of neural stem/progenitor cells via promoting α-Actinin 4 binding toactin filaments.

SCI REP-UK

2016 Nov 22;6:37681.

(IF 3.998)

338. Hu YB, Zou Y, Huang Y, Zhang YF, Lourenco GF, Chen SD, Halliday GM, Wang G, Ren RJ.

ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances AutophagosomeFormation But not Autophagic Aβ Clearance.

Front Cell Neurosci

2016 Nov 2;10:253.

(IF 3.921)

339. He P, Zhang A, Zhou S, Zhang F, Linhardt RJ, Sun P.

Structural elucidation of polysaccharide containing 3-O-methyl galactose from fruiting bodies of Pleurotuscitrinopileatus.

CARBOHYD RES

2016 Nov 3;434:72-76.

(IF 1.841)

340. Zhang T, Wu Y, Fang Z, Yan Q, Zhang S, Sun R, Khaliq J, Li Y.

Low expression of RBMS3 and SFRP1 are associated with poor prognosis in patients with gastric cancer.

Am J Cancer Res

2016 Nov 1;6(11):2679-2689.

(IF 5.177)

341. Wu K, Guo C, Lu X, Wu X, Pan H, Su M.

Impact of perinatal exposure to acetaminophen on hepatocellular metabolic function in offspring.

Am J Transl Res

2016 Dec 15;8(12):5646-5652.

(IF 3.375)

342. Kang X, Wang J, Jiao Y, Tang P, Song L, Xiong D, Yin Y, Pan Z, Jiao X.

Expression of recombinant Newcastle disease virus F protein in Pichia pastoris and its immunogenicityusing flagellin as the adjuvant.

PROTEIN EXPRES PURIF

2016 Dec;128:73-80.

(IF 1.513)

343. Wu Y, Zhao D, Zhuang J, Zhang F, Xu C.

Caspase-8 and Caspase-9 Functioned Differently at Different Stages of the Cyclic Stretch-InducedApoptosis in Human Periodontal Ligament Cells.

PLoS One

2016 Dec 12;11(12):e0168268.

(IF 2.74)

344. Cao B, Liu N, Wang W.

High glucose prevents osteogenic differentiation of mesenchymal stem cells via lncRNA AK028326/CXCL13pathway.

Biomed Pharmacother

2016 Dec;84:544-551.

(IF 4.545)

345. Yan Z, Xingfen W, Wei R, Jun Y, Zhiying M.

Island Cotton Enhanced Disease Susceptibility 1 Gene Encoding a Lipase-Like Protein Plays a Crucial Role in Response to Verticillium dahliae by Regulating the SA Level and H2O2 Accumulation.

Front Plant Sci

2016 Dec 15;7:1830.

(IF 4.402)

346. Zhang P, Li Y, Du Y, Li G, Wang L, Zhou F.

Resveratrol Ameliorated Vascular Calcification by Regulating Sirt-1 and Nrf2.

TRANSPL P

2016 Dec;48(10):3378-3386.

(IF 0.784)

347. Wen Z, Wu C, Cui F, Zhang H, Mei B, Shen M.

The role of osmolality in saline fluid nebulization after tracheostomy: time for changing?

BMC Pulm Med

2016 Dec 9;16(1):179.

(IF 2.813)

348. Bi Z, Zhu Y, Chen Z, Li C, Wang Y, Wang G, Liu G.

Induction of a robust immunity response against novel duck reovirus in ducklings using a subunit vaccineof sigma C protein.

SCI REP-UK

2016 Dec 15;6:39092.

(IF 3.998)

349. Yan T, Yu X, Sun X, Meng D, Jia JM.

A new steroidal saponin, furotrilliumoside from Trillium tschonoskii inhibits lipopolysaccharide-inducedinflammation in Raw264.7 cells by targeting PI3K/Akt, MARK and Nrf2/HO-1 pathways.

Fitoterapia

2016 Dec;115:37-45.

(IF 2.527)

350. Guo C, Yang L, Wan CX, Xia YZ, Zhang C, Chen MH, Wang ZD, Li ZR, Li XM, Geng YD, Kong LY.

Anti-neuroinflammatory effect of Sophoraflavanone G from Sophora alopecuroides in LPS-activated BV2 microglia by MAPK, JAK/STAT and Nrf2/HO-1 signaling pathways.

Phytomedicine

2016 Dec 1;23(13):1629-1637.

(IF 4.268)

351. Liu Y, Zhi D, Li M, Liu D, Wang X, Wu Z, Zhang Z, Fei D, Li Y, Zhu H, Xie Q, Yang H, Li H.

Shengmai Formula suppressed over-activated Ras/MAPK pathway in C. elegans by opening mitochondrial permeability transition pore via regulating cyclophilin D.

SCI REP-UK

2016 Dec 16;6:38934.

(IF 3.998)

352. Chen Z, Liu S, Sun W, Chen L, Yoo D, Li F, Ren S, Guo L, Cong X, Li J, Zhou S, Wu J, Du Y, Wang J.

Nuclear export signal of PRRSV NSP1α is necessary for type I IFN inhibition.

Virology

2016 Dec;499:278-287.

(IF 2.819)

353. Kang L, Yang C, Yin H, Zhao K, Liu W, Hua W, Wang K, Song Y, Tu J, Li S, Luo R, Zhang Y.

MicroRNA-15b silencing inhibits IL-1β-induced extracellular matrix degradation by targeting SMAD3 inhuman nucleus pulposus cells.

Biotechnol Lett

2016 Dec 30.doi: 10.1007/s10529-016-2280-3. [Epub ahead of print]

(IF 1.977)

354. Huang Y, Zhou M, Li C, Chen Y, Fang W, Xu G, Shi X.

Picroside II protects against sepsis via suppressing inflammation in mice.

Am J Transl Res

2016 Dec 15;8(12):5519-5531.

(IF 3.375)

355. Zhao W, Peng F, Shu M, Liu H, Hou X, Wang X, Ye J, Zhao B, Wang K, Zhong C, Xue L, Gao M, Liu Y, Zhao S.

Isogambogenic Acid Inhibits the Growth of Glioma Through Activation of the AMPK-mTOR Pathway.

CELL PHYSIOL BIOCHEM

2017;44(4):1381-1395.

(IF 5.5)

356. Zhang YH, He K, Shi G.

Effects of MicroRNA-499 On the Inflammatory Damage of Endothelial Cells During Coronary Artery Disease Via the Targeting of PDCD4 Through the NF-Κβ/TNF-α Signaling Pathway.

CELL PHYSIOL BIOCHEM

2017;44(1):110-124.

(IF 5.5)

357. Wu X, Zhu H, Yan J, Khan M, Yu X.

Santamarine Inhibits NF-κB Activation and Induces Mitochondrial Apoptosis in A549 Lung Adenocarcinoma Cells via Oxidative Stress.

Biomed Res Int

2017;2017:4734127.

(IF 2.276)

358. Ding L, Zang L, Zhang Y, Zhang Y, Wang X, Ai W, Ding N, Wang H.

Joint toxicity of fluoroquinolone and tetracycline antibiotics to zebrafish (Danio rerio) based on biochemical biomarkers and histopathological observation.

J Toxicol Sci

2017;42(3):267-280.

(IF 1.737)

359. Xu X, Zhang H, Wang K, Tu T, Jiang Y.

Protective Effect of Edaravone against Carbon Monoxide Induced Apoptosis in Rat Primary Cultured Astrocytes.

Biochemistry Research International

2017;2017:5839762.

360. Wang L, Liu WZ, Pei LY, Ke YS, Cui J, Li SC.

Garidisan: Improving the Quality of Ulcer Healing in Rats with Ulcerative Colitis.

EVID-BASED COMPL ALT

2017;2017:8721257.

(IF 1.813)

361. Gao JM, Meng XW, Zhang J, Chen WR, Xia F, Peng K, Ji FH.

Dexmedetomidine Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury by Suppressing TLR4-MyD88-NF-κB Signaling.

Biomed Res Int

2017;2017:1674613.

(IF 2.276)

362. Wang Q, You T, Fan H, Wang Y, Chu T, Poncz M, Zhu L.

Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis.

Platelets

2017 Jan;28(1):82-89.

(IF 3.378)

363. Zhou W, Xu G, Wang Y, Xu Z, Liu X, Xu X, Ren G, Tian K.

Oxidative stress induced autophagy in cancer associated fibroblast enhances proliferation and metabolism of colorectal cancer cells.

Cell Cycle

2017 Jan 2;16(1):73-81.

(IF 3.699)

364. Zhao P, Guo Y, Zhang W, Chai H, Xing H, Xing M.

Neurotoxicity induced by arsenic in Gallus Gallus: Regulation of oxidative stress and heat shock protein response.

Chemosphere

2017 Jan;166:238-245.

(IF 5.778)

365. Xu X, Yan Q, Wang Y, Dong X.

NTN4 is associated with breast cancer metastasis via regulation of EMT-related biomarkers.

Oncol Rep

2017 Jan;37(1):449-457.

(IF 3.417)

366. Cui L, Li Z, Chang X, Cong G, Hao L.

Quercetin attenuates vascular calcification by inhibiting oxidative stress and mitochondrial fission.

VASC PHARMACOL

2017 Jan;88:21-29.

(IF 4.152)

367. Yang J, Yao Y, Wang L, Yang C, Wang F, Guo J, Wang Z, Yang Z, Ming D.

Gastrin-releasing peptide facilitates glutamatergic transmission in the hippocampus and effectively prevents vascular dementia induced cognitive and synaptic plasticity deficits.

Exp Neurol

2017 Jan;287(Pt 1):75-83.

(IF 4.691)

368. Jia M, Wu C, Gao F, Xiang H, Sun N, Peng P, Li J, Yuan X, Li H, Meng X, Tian B, Shi J, Li M.

Activation of NLRP3 inflammasome in peripheral nerve contributes to paclitaxel-induced neuropathic pain.

Mol Pain

2017 Jan-Dec;13:1744806917719804.

(IF 2.696)

369. Yuan XC, Wu CH, Gao F, Li HP, Xiang HC, Zhu H, Pan XL, Lin LX, Liu YS, Yu W, Tian B, Meng XF, Li M.

Activation and expression of μ-calpain in dorsal root contributes to RTX-induced mechanical allodynia.

Mol Pain

2017 Jan-Dec;13:1744806917719169.

(IF 2.696)

370. Su L, Zhang Y, He K, Wei S, Pei H, Wang Q, Yang D, Yang Y.

Activation of transient receptor potential vanilloid 1 accelerates re-endothelialization and inhibits neointimalformation after vascular injury.

J Vasc Surg

2017 Jan;65(1):197-205.e2.

(IF 3.405)

371. Huang L, Zhou B, Wu H, Zheng L, Zhao J.

Effect of apatite formation of biphasic calcium phosphate ceramic (BCP) on osteoblastogenesis usingsimulated body fluid (SBF) with or without bovine serum albumin (BSA).

MAT SCI ENG C-MATER

2017 Jan 1;70(Pt 2):955-961.

(IF 5.88)

372. Li SW, Sun X, He Y, Guo Y, Zhao HJ, Hou ZJ, Xing MW.

Assessment of arsenic trioxide in the heart of Gallus gallus: alterations of oxidative damage parameters,inflammatory cytokines, and cardiac enzymes.

ENVIRON SCI POLLUT R

2017 Jan 4. doi: 10.1007/s11356-016-8223-7. [Epub ahead of print]

(IF 3.056)

373. Mehmood T, Maryam A, Zhang H, Li Y, Khan M, Ma T.

Deoxyelephantopin induces apoptosis in HepG2 cells via oxidative stress, NF-κB inhibition andmitochondrial dysfunction.

Biofactors

2017 Jan 2;43(1):63-72

(IF 4.734)

374. Duan H, Wang C, Zhou K, Wang T, Li Y, Qiu D, Li Q, Zhang Y, Hua Y.

The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placentaltrophoblast cell lines.

Placenta

2017 Jan;49:37-47.

(IF 3.177)

375. Zhao P, Guo Y, Zhang W, Chai H, Xing H, Xing M.

Neurotoxicity induced by arsenic in Gallus Gallus: Regulation of oxidative stress and heat shock proteinresponse.

Chemosphere

2017 Jan;166:238-245.

(IF 5.778)

376. He PF, He L, Zhang AQ, Wang XL, Qu L, Sun PL.

Structure and chain conformation of a neutral polysaccharide from sclerotia of Polyporus umbellatus.

CARBOHYD POLYM

2017 Jan 2;155:61-67.

(IF 7.182)

377. Li SL, Yan J, Zhang YQ, Zhen CL, Liu MY, Jin J, Gao JL, Xiao XL, Shen X, Tai Y, Hu N, Zhang XZ, Sun ZJ, Dong DL.

Niclosamide ethanolamine inhibits artery constriction.

Pharmacol Res

2017 Jan;115:78-86.

(IF 5.893)

378. Lin J, Jing L, Zhu H, Dong FS.

Fundamental research on the action mechanism of the 800 nm semiconductor laser on skin blackheads and coarse pores.

Exp Ther Med

2017 Jan;13(1):235-241.

(IF 1.785)

379. Wang X, Tang P, Guo F, Zhang M, Chen Y, Yan Y, Tian Z, Xu P, Zhang L, Zhang L, Zhang L.

RhoA regulates Activin B-induced stress fiber formation and migration of bone marrow-derived mesenchymal stromal cell through distinct signaling.

BBA-BIOMEMBRANES

2017 Jan;1861(1 Pt A):3011-3018.

(IF 3.411)

380. Shen J, Xu S, Zhou H, Liu H, Jiang W, Hao J, Hu Z.

IL-1β induces apoptosis and autophagy via mitochondria pathway in human degenerative nucleus pulposus cells.

SCI REP-UK

2017 Jan 25;7:41067.

(IF 3.998)

381. Lian YJ, Gong H, Wu TY, Su WJ, Zhang Y, Yang YY, Peng W, Zhang T, Zhou JR, Jiang CL, Wang YX.

Ds-HMGB1 and fr-HMGB induce depressive behavior through neuroinflammation in contrast to nonoxid-HMGB1.

Brain Behav Immun

2017 Jan;59:322-332.

(IF 6.633)

382. Du C, Guo Y, Cheng Y, Han M, Zhang W, Qian H.

Torulene and torularhodin, protects human prostate stromal cells from hydrogen peroxide-induced oxidative stress damage through the regulation of Bcl-2/Bax mediated apoptosis.

FREE RADICAL RES

2017 Feb;51(2):113-123.

(IF 2.839)

383. Du P, Zhao J, Wang J, Liu Y, Ren H, Patel R, Hu C, Zhang W, Huang G.

Sine Oculis Homeobox Homolog 1 Regulates Mitochondrial Apoptosis Pathway Via Caspase-7 In Gastric Cancer Cells.

J Cancer

2017 Feb 25;8(4):636-645.

(IF 3.565)

384. Li SW, Sun X, He Y, Guo Y, Zhao HJ, Hou ZJ, Xing MW.

Assessment of arsenic trioxide in the heart of Gallus gallus: alterations of oxidative damage parameters, inflammatory cytokines, and cardiac enzymes.

ENVIRON SCI POLLUT R

2017 Feb;24(6):5781-5790.

(IF 3.056)

385. Li R, Ma L, Huang H, Ou S, Yuan J, Xu T, Yu X, Liu X, Yang J, Chen Y, Peng X.

Altered Expression of CXCL13 and CXCR5 in Intractable Temporal Lobe Epilepsy Patients and Pilocarpine-Induced Epileptic Rats.

Neurochem Res

2017 Feb;42(2):526-540.

(IF 3.038)

386. Kang H, Liu J, Sun A, Liu X, Fan Y, Deng X.

Vascular smooth muscle cell glycocalyx mediates shear stress-induced contractile responses via a Rho kinase (ROCK)-myosin light chain phosphatase (MLCP) pathway.

SCI REP-UK

2017 Feb 13;7:42092.

(IF 3.998)

387. He L, Xiao D, Feng J, Yao C, Tang L.

Induction of apoptosis of liver cancer cells by nanosecond pulsed electric fields (nsPEFs).

Med Oncol

2017 Feb;34(2):24.

(IF 2.834)

388. Yang H, Gu ZT, Li L, Maegele M, Zhou BY, Li F, Zhao M, Zhao KS.

SIRT1 plays a neuroprotective role in traumatic brain injury in rats via inhibiting the p38 MAPK pathway.

Acta Pharmacol Sin

2017 Feb;38(2):168-181.

(IF 5.064)

389. Ji J, Zeng XN, Cao LL, Zhang L, Zhao Z, Yang DD, Sun XL.

PPARβ/δ activation protects against corticosterone-induced ER stress in astrocytes by inhibiting the CpGhypermethylation of microRNA-181a.

Neuropharmacology

2017 Feb;113(Pt A):396-406.

(IF 4.431)

390. Wang X, Ge QM, Bian F, Dong Y, Huang CM.

Inhibition of TLR4 protects rat islets against lipopolysaccharide-induced dysfunction.

Mol Med Rep

2017 Feb;15(2):805-812.

(IF 2.1)

391. Zhang H, Zhai L, Wang T, Li S, Guo Y.

Picroside II Exerts a Neuroprotective Effect by Inhibiting the Mitochondria Cytochrome C SignalPathwayFollowing Ischemia Reperfusion Injury in Rats.

J Mol Neurosci

2017 Feb;61(2):267-278.

(IF 2.678)

392. Zhang WF, Xiong YW, Zhu TT, Xiong AZ, Bao HH, Cheng XS.

MicroRNA let-7g inhibited hypoxia-induced proliferation of PASMCs via G0/G1 cell cycle arrest by targeting c-myc.

Life Sci

2017 Feb 1;170:9-15.

(IF 3.647)

393. Yan YH, Li SH, Li HY, Lin Y, Yang JX.

Osthole Protects Bone Marrow-Derived Neural Stem Cells from Oxidative Damage through PI3K/Akt-1 Pathway.

Neurochem Res

2017 Feb;42(2):398-405.

(IF 3.038)

394. Huang H, Zhang X, Huang Z, Zhang Y, Zhou Z.

Geniposide reverses multidrug resistance in vitro and in vivo by inhibiting the efflux function and expression of P-glycoprotein.

Exp Ther Med

2017 Feb;13(2):437-442.

(IF 1.785)

395. Yu M, Xu X, Jiang N, Wei W, Li F, He L, Luo X.

Dehydropachymic acid decreases bafilomycin A1 induced β-Amyloid accumulation in PC12 cells.

J Ethnopharmacol

2017 Feb 23;198:167-173.

(IF 3.69)

396. Zhang Y, Zhang L, Sun H, Lv Q, Qiu C, Che X, Liu Z, Jiang J.

Forkhead transcription factor 1 inhibits endometrial cancer cell proliferation via sterol regulatory element-binding protein 1.

Oncol Lett

2017 Feb;13(2):731-737.

(IF 2.311)

397. Cao Y, Wang X, Li S, Wang H, Yu L, Wang P.

The Effects of l-Carnitine Against Cyclophosphamide-Induced Injuries in Mouse Testis.

BASIC CLIN PHARMACOL

2017 Feb;120(2):152-158.

(IF 2.651)

398. Shen P, Hou S, Zhu M, Zhao M, Ouyang Y, Feng J.

Cortical spreading depression preconditioning mediates neuroprotection against ischemic stroke by inducing AMP-activated protein kinase-dependent autophagy in a rat cerebral ischemic/reperfusion injury model.

J Neurochem

2017 Mar;140(5):799-813.

(IF 4.066)

399. Zhang L, Li Z, Feng D, Shen H, Tian X, Li H, Wang Z, Chen G.

Involvement of Nox2 and Nox4 NADPH oxidases in early brain injury after subarachnoid hemorrhage.

FREE RADICAL RES

2017 Mar;51(3):316-328.

(IF 2.839)

400. La X, Zhang L, Li Z, Yang P, Wang Y.

Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells.

ONCOTARGET

2017 Mar 28;8(13):20909-20924.

(IF 5.168)

401. Zhou H, Wu W, Zhang Y, He H, Yuan Z, Zhu Z, Zhao Z.

Selective preservation of cholinergic MeCP2 rescues specific Rett-syndrome-like phenotypes in MeCP2stop mice.

Behav Brain Res

2017 Mar 30;322(Pt A):51-59.

(IF 2.977)

402. Li YY, Xiang Y, Zhang S, Wang Y, Yang J, Liu W, Xue FT.

Thioredoxin-2 protects against oxygen-glucose deprivation/reperfusion injury by inhibiting autophagy and apoptosis in H9c2 cardiomyocytes.

Am J Transl Res

2017 Mar 15;9(3):1471-1482. eCollection 2017.

(IF 3.375)

403. Kang L, Hu J, Weng Y, Jia J, Zhang Y.

Sirtuin 6 prevents matrix degradation through inhibition of the NF-κB pathway in intervertebral disc degeneration.

Exp Cell Res

2017 Mar 15;352(2):322-332.

(IF 3.383)

404. Duan T, Sun W, Zhang M, Ge J, He Y, Zhang J, Zheng Y, Yang W, Shen HM, Yang J, Zhu X, Yu P.

Dietary restriction protects against diethylnitrosamine-induced hepatocellular tumorigenesis by restoring the disturbed gene expression profile.

SCI REP-UK

2017 Mar 6;7:43745.

(IF 3.998)

405. Yang F, Shi L, Liang T, Ji L, Zhang G, Shen Y, Zhu F, Xu L.

Anti-tumor effect of evodiamine by inducing Akt-mediated apoptosis in hepatocellular carcinoma.

BIOCHEM BIOPH RES CO

2017 Mar 25;485(1):54-61.

(IF 2.985)

406. Gong J, Shen S, Yang Y, Qin S, Huang L, Zhang H, Chen L, Chen Y, Li S, She S, Yang M, Ren H, Hu H.

Inhibition of FASN suppresses migration, invasion and growth in hepatoma carcinoma cells by deregulating the HIF-1α/IGFBP1 pathway.

Int J Oncol

2017 Mar;50(3):883-892.

(IF 3.899)

407. Su WJ, Zhang Y, Chen Y, Gong H, Lian YJ, Peng W, Liu YZ, Wang YX, You ZL, Feng SJ, Zong Y, Lu GC, Jiang CL.

NLRP3 gene knockout blocks NF-κB and MAPK signaling pathway in CUMS-induced depression mouse model.

Behav Brain Res

2017 Mar 30;322(Pt A):1-8.

(IF 2.977)

408. Shen H, Liu C, Zhang D, Yao X, Zhang K, Li H, Chen G.

Role for RIP1 in mediating necroptosis in experimental intracerebral hemorrhage model both in vivo and in vitro.

Cell Death Dis

2017 Mar 2;8(3):e2641.

(IF 6.304)

409. Chen L, Gao B, Fang M, Li J, Mi X, Xu X, Wang W, Gu J, Tang B, Zhang Y, Wang Z, Zhan A, Chen G, Wang X.

Lentiviral Vector-Induced Overexpression of RGMa in the Hippocampus Suppresses Seizures and Mossy Fiber Sprouting.

Mol Neurobiol

2017 Mar;54(2):1379-1391.

(IF 4.5)

410. Wang C, Wang Z, Zhou J, Liu S, Wu C, Huang C, Ding Y.

TUC.338 promotes invasion and metastasis in colorectal cancer.

Int J Cancer

2017 Mar 15;140(6):1457-1464.

(IF 5.145)

411. Guo Q.

Changes in mitochondrial function during EMT induced by TGFβ-1 in pancreatic cancer.

Oncol Lett

2017 Mar;13(3):1575-1580.

(IF 2.311)

412. Ge H, Zhang F, Duan P, Zhu N, Zhang J, Ye F, Shan D, Chen H, Lu X, Zhu C, Ge R, Lin Z.

Mitochondrial Uncoupling Protein 2 in human cumulus cells is associated with regulating autophagy and apoptosis, maintaining gap junction integrity and progesterone synthesis.

Mol Cell Endocrinol

2017 Mar 5;443:128-137.

(IF 3.871)

413. Deng L, Jiang L, Lin X, Tseng KF, Lu Z, Wang X.

Luteolin, a novel p90 ribosomal S6 kinase inhibitor, suppresses proliferation and migration in leukemia cells.

Oncol Lett

2017 Mar;13(3):1370-1378.

(IF 2.311)

414. Zhang Y, Dong C, Yang S, Wu J, Xiao K, Huang Y, Li X.

Alkalescent nanotube films on a titanium-based implant: A novel approach to enhance biocompatibility.

MAT SCI ENG C-MATER

2017 Mar 1;72:464-471.

(IF 5.88)

415. Chen Z, Wang Q.

Activation of PPARγ by baicalin attenuates pulmonary hypertension in an infant rat model by suppressing HMGB1/RAGE signaling.

FEBS Open Bio

2017 Mar 8;7(4):477-484.

(IF 2.231)

416. Zhai L, Liu M, Wang T, Zhang H, Li S, Guo Y.

Picroside II protects the blood-brain barrier by inhibiting the oxidative signaling pathway in cerebral ischemia-reperfusion injury.

PLoS One

2017 Apr 7;12(4):e0174414.

(IF 2.74)

417. Liu F, Wang G, Wang X, Che Z, Dong W, Guo X, Wang Z, Chen P, Hou D, Zhang Q, Zhang W, Pan Y, Yang D, Liu H.

Targeting high Aurora kinases expression as an innovative therapy for hepatocellular carcinoma.

ONCOTARGET

2017 Apr 25;8(17):27953-27965.

(IF 5.168)

418. Kang L, Yang C, Yin H, Zhao K, Liu W, Hua W, Wang K, Song Y, Tu J, Li S, Luo R, Zhang Y.

MicroRNA-15b silencing inhibits IL-1β-induced extracellular matrix degradation by targeting SMAD3 in human nucleus pulposus cells.

Biotechnol Lett

2017 Apr;39(4):623-632.

(IF 1.977)

419. Xin P, Li C, Zheng Y, Peng Q, Xiao H, Huang Y, Zhu X.

Efficacy of the dual PI3K and mTOR inhibitor NVP-BEZ235 in combination with imatinib mesylate against chronic myelogenous leukemia cell lines.

DRUG DES DEV THER

2017 Apr 3;11:1115-1126.

(IF 3.216)

420. Liu J, Song G, Lin X, Pang X, Meng T.

Upregulated unique long 16 binding protein 1 detected in preeclamptic placenta affects human extravillous trophoblast cell line (HTR-8/SVneo) invasion by modulating the function of uterine natural killer cells.

Exp Ther Med

2017 Apr;13(4):1447-1455.

(IF 1.785)

421. Qiu M, Liang Z, Chen L, Tan G, Liu L, Wang K, Chen H, Liu J.

MicroRNA-200c suppresses cell growth and metastasis by targeting Bmi-1 and E2F3 in renal cancer cells.

Exp Ther Med

2017 Apr;13(4):1329-1336.

(IF 1.785)

422. Hou X, Yang C, Zhang L, Hu T, Sun D, Cao H, Yang F, Guo G, Gong C, Zhang X, Tong A, Li R, Zheng Y.

Killing colon cancer cells through PCD pathways by a novel hyaluronic acid-modified shell-core nanoparticle loaded with RIP3 in combination with chloroquine.

Biomaterials

2017 Apr;124:195-210.

(IF 10.317)

423. Geng Y, Mi J, Gao H, Jia H, Wang W.

Spatiotemporal expression of Wnt3a during striated muscle complex development in rat embryos with ethylenethiourea-induced anorectal malformations.

Mol Med Rep

2017 Apr;15(4):1601-1606.

(IF 2.1)

424. Ma J, Li R, Wang H, Li D, Wang X, Zhang Y, Zhen W, Duan H, Yan G, Li Y.

Transcriptomics Analyses Reveal Wheat Responses to Drought Stress during Reproductive Stages under Field Conditions.

Front Plant Sci

2017 Apr 21;8:592.

(IF 4.402)

425. Li RJ, Gao CY, Guo C, Zhou MM, Luo J, Kong LY.

The Anti-inflammatory Activities of Two Major Withanolides from Physalis minima Via Acting on NF-κB,STAT3, and HO-1 in LPS-Stimulated RAW264.7 Cells.

Inflammation

2017 Apr;40(2):401-413.

(IF 3.212)

426. Li RJ, Gao CY, Guo C, Zhou MM, Luo J, Kong LY.

The Anti-inflammatory Activities of Two Major With anolides from Physalis minima Via Acting on NF-κB,STAT3, and HO-1 in LPS-Stimulated RAW264.7 Cells.

Inflammation

2017 Apr;40(2):401-413.

(IF 3.212)

427. Zan J, Liu S, Sun DN, Mo KK, Yan Y, Liu J, Hu BL, Gu JY, Liao M, Zhou JY.

Rabies Virus Infection Induces Microtubule Depolymerization to Facilitate Viral RNA Synthesis by Upregulating HDAC6.

FRONT CELL INFECT MI

2017 Apr 26;7:146.

(IF 4.123)

428. Qi Y, Ruan J, Wang M, Dai Y, Zhou Q, Gui S, Zhang S, Wang Y.

Effects of hyperbaric oxygen treatment on gastric cancer cell line SGC7901.

Biomed Rep.

2017 Apr;6(4):475-479.

429. Han Y, Wu JZ, Shen JZ, Chen L, He T, Jin MW, Liu H.

Pentamethylquercetin induces adipose browning and exerts beneficial effects in 3T3-L1 adipocytes and high-fat diet-fed mice.

SCI REP-UK

2017 Apr 25;7(1):1123.

(IF 3.998)

430. Zhou Q, Deng Q, Hu B, Wang YJ, Chen JL, Cui JJ, Cao S, Song HN.

Ultrasound combined with targeted cationic microbubble-mediated angiogenesis gene transfection improves ischemic heart function.

Exp Ther Med

2017 May;13(5):2293-2303.

(IF 1.785)

431. Zhang J, Zhang Z, Bao J, Yu Z, Cai M, Li X, Wu T, Xiang J, Cai D.

Jia-Jian-Di-Huang-Yin-Zi decoction reduces apoptosis induced by both mitochondrial and endoplasmic reticulum caspase12 pathways in the mouse model of Parkinson's disease.

J Ethnopharmacol

2017 May 5;203:69-79.

(IF 3.69)

432. Chen S, Lv X, Hu B, Shao Z, Wang B, Ma K, Lin H, Cui M.

RIPK1/RIPK3/MLKL-mediated necroptosis contributes to compression-induced rat nucleus pulposus cells death.

Apoptosis

2017 May;22(5):626-638.

(IF 4.543)

433. Xu Z, Diao Z, Liu R, Liu W.

Molecular mechanism of smurf2 in regulating the expression of SnoN in diabetic nephropathy.

Mol Med Rep

2017 May;15(5):2560-2566.

(IF 2.1)

434. Li Z, Gu J, Liu J, Zhu Q, Lu H, Lu Y, Rao J, Lu L, Wang X.

Chitinase 3-like-1 deficient donor splenocytes accentuated the pathogenesis of acute graft-versus-host diseases through regulating T cell expansion and type I inflammation.

Int Immunopharmacol

2017 May;46:201-209.

(IF 3.943)

435. Huang H, Wang J, Zhang J, Luo Z, Li D, Qiu X, Peng Y, Xu Z, Xu P, Xu Z.

Nitrobenzylthioinosine mimics adenosine to attenuate the epileptiform discharge of hippocampal neurons from epileptic rats.

ONCOTARGET

2017 May 30;8(22):35573-35582.

(IF 5.168)

436. Lu Z, Xiao Y, Liu X, Zhang Z, Xiao F, Bi Y.

Matrine reduces the proliferation of A549 cells via the p53/p21/PCNA/eIF4E signaling pathway.

Mol Med Rep

2017 May;15(5):2415-2422.

(IF 2.1)

437. Li BY, Gao YH, Pei JR, Yang YM, Zhang W, Sun DJ.

ClC-7/Ostm1 contribute to the ability of tea polyphenols to maintain bone homeostasis in C57BL/6 mice, protecting against fluorosis.

Int J Mol Med

2017 May;39(5):1155-1163.

(IF 3.098)

438. Han T, Shu T, Dong S, Li P, Li W, Liu D, Qi R, Zhang S, Zhang L.

Chemokine-like factor-like MARVEL transmembrane domain-containing 3 expression is associated with a favorable prognosis in esophageal squamous cell carcinoma.

Oncol Lett

2017 May;13(5):2982-2988.

(IF 2.311)

439. Li X, Wu Y, Zhang W, Gong J, Cheng Y.

Pre-conditioning with tanshinone IIA attenuates the ischemia/reperfusion injury caused by liver grafts via regulation of HMGB1 in rat Kupffer cells.

Biomed Pharmacother

2017 May;89:1392-1400.

(IF 4.545)

440. Liu Y, Zhang W, Wu X, Gong J.

Foxo3a-dependent Bim transcription protects mice from a high fat diet via inhibition of activation of the NLRP3 inflammasome by facilitating autophagy flux in Kupffer cells.

ONCOTARGET

2017 May 23;8(21):34258-34267.

(IF 5.168)

441. Qiao J, Rong L, Wang Z, Zhang M.

Involvement of Akt/GSK3β/CREB signaling pathway on chronic omethoate induced depressive-like behavior and improvement effects of combined lithium chloride and astaxanthin treatment.

Neurosci Lett

2017 May 10;649:55-61.

(IF 2.274)

442. Guo T, Lin Q, Li X, Nie Y, Wang L, Shi L, Xu W, Hu T, Guo T, Luo F.

Octacosanol Attenuates Inflammation in Both RAW264.7 Macrophages and a Mouse Model of Colitis.

J AGR FOOD CHEM

2017 May 10;65(18):3647-3658.

(IF 4.192)

443. Sun X, He Y, Guo Y, Li S, Zhao H, Wang Y, Zhang J, Xing M.

Arsenic affects inflammatory cytokine expression in Gallus gallus brain tissues.

BMC Vet Res

2017 Jun 5;13(1):157.

(IF 1.835)

444. Li GJ, Zhao GQ, Yang JP, Zhou YC, Yang KY, Lei YJ, Huang YC.

Effect of miR-1244 on cisplatin-treated non-small cell lung cancer via MEF2D expression.

Oncol Rep

2017 Jun;37(6):3475-3483.

(IF 3.417)

445. Cao L, Huang B, Fu X, Yang J, Lin Y, Lin F.

Effects of tanshinone IIA on the regulation of renal proximal tubular fibrosis.

Mol Med Rep

2017 Jun;15(6):4247-4252.

(IF 2.1)

446. Chen L, Ran Q, Xiang Y, Xiang L, Chen L, Li F, Wu J, Wu C, Li Z.

Co-Activation of PKC-δ by CRIF1 Modulates Oxidative Stress in Bone Marrow Multipotent Mesenchymal Stromal Cells after Irradiation by Phosphorylating NRF2 Ser40.

Theranostics

2017 Jun 25;7(10):2634-2648.

(IF 8.579)

447. Chen Y, Fang L, Li G, Zhang J, Li C, Ma M, Guan C, Bai F, Lyu J, Meng QH.

Synergistic inhibition of colon cancer growth by the combination of methylglyoxal and silencing of glyoxalase I mediated by the STAT1 pathway.

ONCOTARGET

2017 Jun 22;8(33):54838-54857.

(IF 5.168)

448. Xu X, Xia L, Chen W, Huang Q.

Detoxification of hexavalent chromate by growing Paecilomyces lilacinus XLA.

Environ Pollut

2017 Jun;225:47-54.

(IF 6.792)

449. Duan HY, Ma D, Zhou KY, Wang T, Zhang Y, Li YF, Wu JL, Hua YM, Wang C.

Effect of Histone Deacetylase Inhibition on the Expression of Multidrug Resistance-associated Protein 2 in a Human Placental Trophoblast Cell Line.

CHINESE MED J-PEKING

2017 Jun 5;130(11):1352-1360.

(IF 1.585)

450. Yang Y, Wang Y, Kong Y, Zhang X, Bai L.

The effects of different frequency treadmill exercise on lipoxin A4 and articular cartilage degeneration in an experimental model of monosodium iodoacetate-induced osteoarthritis in rats.

PLoS One

2017 Jun 8;12(6):e0179162.

(IF 2.74)

451. Song C, Xue L.

Roles of the μ-opioid receptor and its related signaling pathways in the pathogenesis of premenstrual syndrome liver-qi stagnation.

Exp Ther Med

2017 Jun;13(6):3130-3136.

(IF 1.785)

452. Xie J, Shen S, Chen R, Xu J, Dong K, Huang J, Lu Q, Zhu W, Ma T, Jia L, Cai H, Zhu T.

Synthesis, characterization and antitumor activity of Ln(III) complexes with hydrazone Schiff base derived from 2-acetylpyridine and isonicotinohydrazone.

Oncol Lett

2017 Jun;13(6):4413-4419.

(IF 2.311)

453. Wu J, Gao L, Shang L, Wang G, Wei N, Chu T, Chen S, Zhang Y, Huang J, Wang J, Lin R.

Ecdysterones from Rhaponticum carthamoides (Willd.) Iljin reduce hippocampal excitotoxic cell loss and upregulate mTOR signaling in rats.

Fitoterapia

2017 Jun;119:158-167.

(IF 2.527)

454. An HM, Lin C, Gu C, Chen JJ, Sun WX, Jin M, Zhang TL, Qiu MF, Hu B.

Di-Huang-Yi-Zhi herbal formula attenuates amyloid-β-induced neurotoxicity in PC12 cells.

Exp Ther Med

2017 Jun;13(6):3003-3008.

(IF 1.785)

455. Zhao D, Lv C, Liu G, Mi Y, Zhang C.

Effect of estrogen on chick primordial follicle development and activation.

Cell Biol Int

2017 Jun;41(6):630-638.

(IF 2.571)

456. Liu L, Zuo Z, Lu S, Liu A, Liu X.

Naringin attenuates diabetic retinopathy by inhibiting inflammation, oxidative stress and NF-κB activation in vivo and in vitro.

Iran J Basic Med Sci

2017 Jul;20(7):813-821.

(IF 2.146)

457. Maryam A, Mehmood T, Zhang H, Li Y, Khan M, Ma T.

Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress.

SCI REP-UK

2017 Jul 24;7(1):6242.

(IF 3.998)

458. Fan L, Luo J, Li X, Chen M, Shu W, Qu X.

Activation of Na+/H+ exchanger other than formation of transmembrane pore underlies the cytotoxicity of nematocyst venom from Chrysaora helvola Brandt jellyfish.

Toxicon

2017 Jul;133:162-168.

(IF 2.201)

459. Yang W, Hong L, Xu X, Wang Q, Huang J, Jiang L.

LncRNA GAS5 suppresses the tumorigenesis of cervical cancer by downregulating miR-196a and miR-205.

TUMOR BIOL 

2017 Jul;39(7):1010428317711315.

(IF 3.65)

460. Zhang Q, Hu X, Hui F, Song Q, Cui C, Wang C, Zhao Q.

Ethanol extract and its dichloromethane fraction of Alpinia oxyphylla Miquel exhibited hepatoprotective effects against CCl4-induced oxidative damage in vitro and in vivo with the involvement of Nrf2.

Biomed Pharmacother

2017 Jul;91:812-822.

(IF 4.545)

461. Gao Y, Ma L, Luo CL, Wang T, Zhang MY, Shen X, Meng HH, Ji MM, Wang ZF, Chen XP, Tao LY.

IL-33 Exerts Neuroprotective Effect in Mice Intracerebral Hemorrhage Model Through Suppressing Inflammation/Apoptotic/Autophagic Pathway.

Mol Neurobiol

2017 Jul;54(5):3879-3892.

(IF 4.5)

462. Jiang LB, Liu HX, Zhou YL, Sheng SR, Xu HZ, Xue EX.

An ultrastructural study of chondroptosis: programmed cell death in degenerative intervertebral discs in vivo.

J Anat

2017 Jul;231(1):129-139.

(IF 2.013)

463. Liu H, Zhong H, Yin Y, Jiang Z.

Genistein has beneficial effects on hepatic steatosis in high fat-high sucrose diet-treated rats.

Biomed Pharmacother

2017 Jul;91:964-969.

(IF 4.545)

464. Ma Y, Fu S, Lu L, Wang X.

Role of androgen receptor on cyclic mechanical stretch-regulated proliferation of C2C12 myoblasts and its upstream signals: IGF-1-mediated PI3K/Akt and MAPKs pathways.

Mol Cell Endocrinol

2017 Jul 15;450:83-93.

(IF 3.871)

465. Chang H, Li X, Cai Q, Li C, Tian L, Chen J, Xing X, Gan Y, Ouyang W, Yang Z.

The PI3K/Akt/mTOR pathway is involved in CVB3-induced autophagy of HeLa cells.

Int J Mol Med

2017 Jul;40(1):182-192.

(IF 3.098)

466. Xie X, Feng J, Kang Z, Zhang S, Zhang L, Zhang Y, Li X, Tang Y.

Taxifolin protects RPE cells against oxidative stress-induced apoptosis.

Mol Vis

2017 Jul 27;23:520-528. eCollection 2017.

(IF 2.202)

467. Shen M, Zhou L, Zhou P, Zhou W, Lin X.

Lymphotoxin β receptor activation promotes mRNA expression of RelA and pro-inflammatory cytokines TNFα and IL-1β in bladder cancer cells.

Mol Med Rep

2017 Jul;16(1):937-942.

(IF 2.1)

468. Liu Z, Li C, Meng X, Bai Y, Qi J, Wang J, Zhou Q, Zhang W, Zhang X.

Hypoxia-inducible factor-lα mediates aggrecan and collagen Π expression via NOTCH1 signaling in nucleus pulposus cells during intervertebral disc degeneration.

BIOCHEM BIOPH RES CO

2017 Jul 1;488(3):554-561.

(IF 2.985)

469. Luo J, Tao Y, Liang X, Chen Y, Zhang L, Jiang F, Liu S, Ye Z, Li Z, Shi W.

Flow control effect of necrostatin-1 on cell death of the NRK-52E renal tubular epithelial cell line.

Mol Med Rep

2017 Jul;16(1):57-62.

(IF 2.1)

470. Zhang J, Li G, Chen Y, Fang L, Guan C, Bai F, Ma M, Lyu J, Meng QH.

Metformin Inhibits Tumorigenesis and Tumor Growth of Breast Cancer Cells by Upregulating miR-200c but Downregulating AKT2 Expression.

J Cancer

2017 Jul 2;8(10):1849-1864.

(IF 3.565)

471. Li X, Ma M, Zhang X, Deng L, Wang Y, Bian Z, Cai S, Peng B, Yang J, Chen Y.

Ethanol extract of gardenia fruit alleviates renal interstitial fibrosis induced by unilateral ureteral obstruction in rats.

Exp Ther Med

2017 Aug;14(2):1381-1388.

(IF 1.785)

472. Mei B, Li H, Zhu J, Yang J, Yang Z, Wen Z, Li X, Shen H, Shen M, Chen G.

Neuroprotection of Botch in experimental intracerebral hemorrhage in rats.

ONCOTARGET

2017 Aug 24;8(56):95346-95360.

(IF 5.168)

473. Tian C, Yuan Z, Xu D, Ding P, Wang T, Zhang L, Jiang Z.

Inhibition of glycolysis by a novel EGFR/HER2 inhibitor KU004 suppresses the growth of HER2+ cancer.

Exp Cell Res

2017 Aug 15;357(2):211-221.

(IF 3.383)

474. Cui C, Shi X.

miR-187 inhibits tumor growth and invasion by directly targeting MAPK12 in osteosarcoma.

Exp Ther Med

2017 Aug;14(2):1045-1050.

(IF 1.785)

475. Wang J, He W, Guo L, Zhang Y, Li H, Han S, Shen D.

The ACE2-Ang (1-7)-Mas receptor axis attenuates cardiac remodeling and fibrosis in post-myocardial infarction.

Mol Med Rep

2017 Aug;16(2):1973-1981.

(IF 2.1)

476. Sun CL, Chen L, Xu J, Qu W, Guan L, Liu WY, Akihisa T, Feng F, Zhang J.

Melanogenesis-Inhibitory and Antioxidant Activities of Phenolics from Periploca forrestii.

Chem Biodivers

2017 Aug;14(8).

(IF 2.039)

477. Li Z, Gu J, Zhu Q, Liu J, Lu H, Lu Y, Wang X.

Obese donor mice splenocytes aggravated the pathogenesis of acute graft-versus-host disease via regulating differentiation of Tregs and CD4+ T cell induced-type I inflammation.

ONCOTARGET

2017 Aug 24;8(43):74880-74896.

(IF 5.168)

478. He P, Wang W, Sanogo B, Zeng X, Sun X, Lv Z, Yuan D, Duan L, Wu Z.

Molluscicidal activity and mechanism of toxicity of a novel salicylanilide ester derivative against Biomphalaria species.

PARASITE VECTOR

2017 Aug 10;10(1):383.

(IF 2.824)

479. Tang H, Gao Y, Zhang Q, Nie K, Zhu R, Gao L, Feng S, Wang L, Zhao J, Huang Z, Zhang Y, Wang L.

Chronic cerebral hypoperfusion independently exacerbates cognitive impairment within the pathopoiesis of Parkinson's disease via microvascular pathologys.

Behav Brain Res

2017 Aug 30;333:286-294.

(IF 2.977)

480. Zhang Y, Cui W, Zhai Q, Zhang T, Wen X.

N-acetylcysteine ameliorates repetitive/stereotypic behavior due to its antioxidant properties without activation of the canonical Wnt pathway in a valproic acid-induced rat model of autism.

Mol Med Rep

2017 Aug;16(2):2233-2240.

(IF 2.1)

481. Zhang P, Chen Z, Ning K, Jin J, Han X.

Inhibition of B7-H3 reverses oxaliplatin resistance in human colorectal cancer cells.

BIOCHEM BIOPH RES CO

2017 Aug 26;490(3):1132-1138.

(IF 2.985)

482. Zhang W, Zhang J.

Dexmedetomidine preconditioning protects against lung injury induced by ischemia-reperfusion through inhibition of autophagy.

Exp Ther Med

2017 Aug;14(2):973-980.

(IF 1.785)

483. Wang S, Liu B, Zhang J, Sun W, Dai C, Sun W, Li Q.

Centromere protein U is a potential target for gene therapy of human bladder cancer.

Oncol Rep

2017 Aug;38(2):735-744.

(IF 3.417)

484. Fu S, Xu H, Gu M, Liu C, Wan X, Chen Y, Chen Q, Zhou J, Wang Z.

Lack of adiponectin and adiponectin receptor 1 contributes to benign prostatic hyperplasia.

ONCOTARGET

2017 Aug 3;8(51):88537-88551.

(IF 5.168)

485. Che J, Shen WZ, Deng Y, Dai YH, Liao YD, Yuan XL, Zhang P.

Effects of lentivirus-mediated silencing of Periostin on tumor microenvironment and bone metastasis via the integrin-signaling pathway in lung cancer.

Life Sci

2017 Aug 1;182:10-21.

(IF 3.647)

486. Wen Z, Mei B, Li H, Dou Y, Tian X, Shen M, Chen G.

P2X7 Participates in Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via MAPKs Signaling Pathways.

Neurochem Res

2017 Aug;42(8):2372-2383.

(IF 3.038)

487. Liu H, Shen W, Zhang C, Cui Y, Li J, Zhang T, Chen W, Wang D.

Diffusion kurtosis imaging evaluating epithelial-mesenchymal transition in colorectal carcinoma xenografts model: a preliminary study.

SCI REP-UK

2017 Sep 12;7(1):11424.

(IF 3.998)

488. Zhao X, Zhang C, Hua M, Wang R, Zhong C, Yu J, Han F, He N, Zhao Y, Liu G, Zheng N, Ji C, Ma D.

NLRP3 inflammasome activation plays a carcinogenic role through effector cytokine IL-18 in lymphoma.

ONCOTARGET

2017 Sep 18;8(65):108571-108583.

(IF 5.168)

489. Li S, Wang H, Wang X, Wang Y, Feng J.

Betaine affects muscle lipid metabolism via regulating the fatty acid uptake and oxidation in finishing pig.

J ANIM SCI BIOTECHNO

2017 Sep 1;8:72.

(IF 4.167)

490. Sui X, Zhang C, Zhou J, Cao S, Xu C, Tang F, Zhi X, Chen B, Wang S, Yin L.

Resveratrol inhibits Extranodal NK/T cell lymphoma through activation of DNA damage response pathway.

J EXP CLIN CANC RES

2017 Sep 26;36(1):133.

(IF 7.068)

491. Liu N, Zheng M, Li S, Bai H, Liu Z, Hou CH, Zhang S, Pu J.

Genetic Mechanisms Contribute to the Development of Heart Failure in Patients with Atrioventricular Block and Right Ventricular Apical Pacing.

SCI REP-UK

2017 Sep 6;7(1):10676.

(IF 3.998)

492. Xiao W, Zhao S, Shen F, Liang J, Chen J.

Overexpression of CD147 is associated with poor prognosis, tumor cell migration and ERK signaling pathway activation in hepatocellular carcinoma.

Exp Ther Med

2017 Sep;14(3):2637-2642.

(IF 1.785)

493. Zhang B, Liu C, Yang N, Wang X.

A comparative study of changes of autophagy in rat models of CLP versus LPS induced sepsis.

Exp Ther Med

2017 Sep;14(3):2194-2200.

(IF 1.785)

494. Yang C, Guo WB, Zhang WS, Bian J, Yang JK, Zhou QZ, Chen MK, Peng W, Qi T, Wang CY, Liu CD.

Comprehensive proteomics analysis of exosomes derived from human seminal plasma.

Andrology

2017 Sep;5(5):1007-1015.

(IF 3.106)

495. Lu W, Kang J, Hu K, Tang S, Zhou X, Xu L, Li Y, Yu S.

The role of the Nox4-derived ROS-mediated RhoA/Rho kinase pathway in rat hypertension induced by chronic intermittent hypoxia.

Sleep Breath

2017 Sep;21(3):667-677.

(IF 2.162)

496. Shi L, Lin Q, Li X, Nie Y, Sun S, Deng X, Wang L, Lu J, Tang Y, Luo F.

Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-γ activation.

Mol Nutr Food Res

2017 Sep;61(9).

(IF 5.309)

497. Xue R, Yang J, Wu J, Meng Q, Hao J.

Coenzyme Q10 inhibits the activation of pancreatic stellate cells through PI3K/AKT/mTOR signaling pathway.

ONCOTARGET

2017 Sep 23;8(54):92300-92311.

(IF 5.168)

498. Li JJ, Wu XY, Chen JL, Chen GR, Xu J, Gu Y, Song HP.

Antiplatelet drug ticagrelor delays gastric ulcer healing in rats.

Exp Ther Med

2017 Oct;14(4):3774-3779.

(IF 1.785)

499. Wang X, Lin B, Nie L, Li P.

microRNA-20b contributes to high glucose-induced podocyte apoptosis by targeting SIRT7.

Mol Med Rep

2017 Oct;16(4):5667-5674.

(IF 2.1)

500. Zhou DY, Qin J, Huang J, Wang F, Xu GP, Lv YT, Zhang JB, Shen LM.

Zoledronic acid inhibits infiltration of tumor-associated macrophages and angiogenesis following transcatheter arterial chemoembolization in rat hepatocellular carcinoma models.

Oncol Lett

2017 Oct;14(4):4078-4084.

(IF 2.311)

501. Wang C, Hou W, Guo X, Li J, Hu T, Qiu M, Liu S, Mo X, Liu X.

Two-phase electrospinning to incorporate growth factors loaded chitosan nanoparticles into electrospun fibrous scaffolds for bioactivity retention and cartilage regeneration.

MAT SCI ENG C-MATER

2017 Oct 1;79:507-515.

(IF 5.88)

502. Wang Z, Yi X, Du L, Wang H, Tang J, Wang M, Qi C, Li H, Lai Y, Xia W, Tang A.

A study of Epstein-Barr virus infection in the Chinese tree shrew(Tupaia belangeri chinensis).

Virol J

2017 Oct 6;14(1):193.

(IF 2.579)

503. Sun G, Yang W, Zhang Y, Zhao M.

Esculentoside A ameliorates cecal ligation and puncture-induced acute kidney injury in rats.

EXP ANIM TOKYO

2017 Oct 30;66(4):303-312.

(IF 1.574)

504. Liu J, Yu L, Chen C, Zhou J, Gong X, Li D, Hou D, Song Y, Shao C.

The Expression of Dectin-1, Irak1 and Rip2 During the Host Response to Aspergillus fumigatus.

Mycopathologia

2017 Oct 23.

(IF 2.452)

505. Pan YJ, Wei LL, Wu XJ, Huo FC, Mou J, Pei DS.

MiR-106a-5p inhibits the cell migration and invasion of renal cell carcinoma through targeting PAK5.

Cell Death Dis

2017 Oct 26;8(10):e3155.

(IF 6.304)

506. Ye X, Wang H, Kan J, Li J, Huang T, Xiong G, Hu Z.

A novel 17β-hydroxysteroid dehydrogenase in Rhodococcus sp. P14 for transforming 17β-estradiol to estrone.

CHEM-BIOL INTERACT

2017 Oct 1;276:105-112.

(IF 3.723)

507. Li SW, Guo Y, He Y, Sun X, Zhao HJ, Wang Y, Wang YJ, Xing MW.

Assessment of arsenic trioxide toxicity on cock muscular tissue: alterations of oxidative damage parameters, inflammatory cytokines and heat shock proteins.

Ecotoxicology

2017 Oct;26(8):1078-1088.

(IF 2.535)

508. Li S, Wang Y, Zhao H, He Y, Li J, Jiang G, Xing M.

NF-κB-mediated inflammation correlates with calcium overload under arsenic trioxide-induced myocardial damage in Gallus gallus.

Chemosphere

2017 Oct;185:618-627.

(IF 5.778)

509. Li Z, Lu H, Gu J, Liu J, Zhu Q, Lu Y, Wang X.

Chitinase 3-Like-1-Deficient Splenocytes Deteriorated the Pathogenesis of Acute Graft-Versus-Host Disease via Regulating Differentiation of Tfh Cells.

Inflammation

2017 Oct;40(5):1576-1588.

(IF 3.212)

510. Wang Y, Zhao H, Shao Y, Liu J, Li J, Xing M.

Copper or/and arsenic induce oxidative stress-cascaded, nuclear factor kappa B-dependent inflammation and immune imbalance, trigging heat shock response in the kidney of chicken.

ONCOTARGET

2017 Oct 3;8(58):98103-98116.

(IF 5.168)

511. Li Q, Ge YL, Li M, Fang XZ, Yuan YP, Liang L, Huang SQ.

miR-127 contributes to ventilator-induced lung injury.

Mol Med Rep

2017 Oct;16(4):4119-4126.

(IF 2.1)

512. Liu D, Miao H, Zhao Y, Kang X, Shang S, Xiang W, Shi R, Hou A, Wang R, Zhao K, Liu Y, Ma Y, Luo H, Miao H, He F.

NF-κB potentiates tumor growth by suppressing a novel target LPTS.

Cell Commun Signal

2017 Oct 10;15(1):39.

(IF 4.344)

513. Ji Y, Teng L, Zhang R, Sun J, Guo Y.

NRG-1β exerts neuroprotective effects against ischemia reperfusion-induced injury in rats through the JNK signaling pathway.

Neuroscience

2017 Oct 24;362:13-24.

(IF 3.056)

514. Zhou X, Li Y, Li C.

Autophagy plays a positive role in zinc-induced apoptosis in intestinal porcine epithelial cells.

Toxicol In Vitro

2017 Oct;44:392-402.

(IF 2.959)

515. Meng X, Zhao Y, Wang J, Gao Z, Geng Q, Liu X.

Regulatory roles of miRNA-758 and matrix extracellular phosphoglycoprotein in cervical cancer.

Exp Ther Med

2017 Oct;14(4):2789-2794.

(IF 1.785)

516. Zhang J, Song N, Zang D, Yu J, Li J, Di W, Guo R, Zhao W, Wang H.

c-Myc promotes tumor proliferation and anti‑apoptosis by repressing p21 in rhabdomyosarcomas.

Mol Med Rep

2017 Oct;16(4):4089-4094.

(IF 2.1)

517. Kong M, Wu Y, Liu Y.

The impact of HuD protein on the intestinal nervous system in the terminal rectum of animal models of congenital anorectal malformation.

Mol Med Rep

2017 Oct;16(4):4797-4802.

(IF 2.1)

518. Wang X, Yu Y, Li M, Yu Y, Liu G, Xie Y, Liu Y, Yang X, Zou Y, Ge J, Chen R.

Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells.

Exp Mol Pathol

2017 Oct;103(2):210-217.

(IF 2.28)

519. Wu M, Wu Y, Qian H, Tao Y, Pang J, Wang Y, Chen Y.

Type II cGMP‑dependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells.

Mol Med Rep

2017 Oct;16(4):5729-5737.

(IF 2.1)

520. Zhai F, Song N, Ma J, Gong W, Tian H, Li X, Jiang C, Wang H.

FGF18 inhibits MC3T3‑E1 cell osteogenic differentiation via the ERK signaling pathway.

Mol Med Rep

2017 Oct;16(4):4127-4132.

(IF 2.1)

521. Mehmood T, Maryam A, Tian X, Khan M, Ma T.

Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.

J Cancer

2017 Oct 17;8(18):3707-3717.

(IF 3.565)

522. Zhu SM, Rao T, Yang X, Ning JZ, Yu WM, Ruan Y, Yuan R, Li CL, Jiang K, Hu W, Li HY, Cheng F.

Autophagy may play an important role in varicocele.

Mol Med Rep

2017 Oct;16(4):5471-5479.

(IF 2.1)

523. Yang W, Huang L, Gao J, Wen S, Tai Y, Chen M, Huang Z, Liu R, Tang C, Li J.

Betaine attenuates chronic alcohol‑induced fatty liver by broadly regulating hepatic lipid metabolism.

Mol Med Rep

2017 Oct;16(4):5225-5234.

(IF 2.1)

524. Li J, Liu B, Cai M, Lin X, Lou S.

Glucose metabolic alterations in hippocampus of diabetes mellitus rats and the regulation of aerobic exercise.

Behav Brain Res

2017 Nov 4. pii: S0166-4328(17)31309-8.

(IF 2.977)

525. Meng L, Huo X, Feng M, Fang Y, Han B, Hu H, Wu F, Li J.

Proteomics Reveals the Molecular Underpinnings of Stronger Learning and Memory in Eastern Compared to Western Bees.

Mol Cell Proteomics

2017 Nov 29. pii: mcp.RA117.000159.

(IF 4.87)

526. Han X, Li H, Zhang Y, Qin J, Yang Q, Wang L, Yuan M, Xia C.

Brain lipid-binding protein promotes proliferation and modulates cell cycle in C6 rat glioma cells.

Int J Oncol

2017 Nov;51(5):1439-1448.

(IF 3.899)

527. Li J, Zhang L, Xia Q, Fu J, Zhou Z, Lin F.

Hedgehog signaling inhibitor GANT61 induces endoplasmic reticulum stress-mediated protective autophagy in hepatic stellate cells.

BIOCHEM BIOPH RES CO

2017 Nov 4;493(1):487-493.

(IF 2.985)

528. Lin J, Chen Z, Huang Z, Chen F, Ye Z, Lin S, Wang W.

Upregulation of T-cadherin suppresses cell proliferation, migration and invasion of gastric cancer in vitro.

Exp Ther Med

2017 Nov;14(5):4194-4200.

(IF 1.785)

529. Wang YL, Shao X, Wang F, Zeng L, Hu L, Cui SQ, Hou G, Huang DN.

Intron-specific shRNA-mediated downregulation of survivin and promotion of apoptosis in HeLa cells.

Oncol Lett

2017 Nov;14(5):5927-5933.

(IF 2.311)

530. Huang C, Li N, Yuan S, Ji X, Ma M, Rao K, Wang Z.

Aryl- and alkyl-phosphorus-containing flame retardants induced mitochondrial impairment and cell death in Chinese hamster ovary (CHO-k1) cells.

Environ Pollut

2017 Nov;230:775-786.

(IF 6.792)

531. Wang H, Zhu L, Feng X, Zhang H, Luo Q, Chen F.

Oridonin induces G2/M cell cycle arrest and apoptosis in human oral squamous cell carcinoma.

Eur J Pharmacol

2017 Nov 15;815:282-289.

(IF 3.263)

532. Huo R, Zeng B, Zeng L, Cheng K, Li B, Luo Y, Wang H, Zhou C, Fang L, Li W, Niu R, Wei H, Xie P.

Microbiota Modulate Anxiety-Like Behavior and Endocrine Abnormalities in Hypothalamic-Pituitary-Adrenal Axis.

FRONT CELL INFECT MI

2017 Nov 30;7:489.

(IF 4.123)

533. Chen R, Xu L, Fan Q, Li M, Wang J, Wu L, Li W, Duan J, Chen Z.

Hierarchical pulmonary target nanoparticles via inhaled administration for anticancer drug delivery.

Drug Deliv

2017 Nov;24(1):1191-1203.

(IF 4.902)

534. Kang M, Shi J, Peng N, He S.

MicroRNA-211 promotes non-small-cell lung cancer proliferation and invasion by targeting MxA.

ONCOTARGETS THER

2017 Nov 28;10:5667-5675.

(IF 3.337)

535. Wang B, Lian YJ, Su WJ, Peng W, Dong X, Liu LL, Gong H, Zhang T, Jiang CL, Wang YX.

HMGB1 mediates depressive behavior induced by chronic stress through activating the kynurenine pathway.

Brain Behav Immun

2017 Nov 28. pii: S0889-1591(17)30518-4.

(IF 6.633)

536. Zhang W, Liu Y, Wu M, Zhu X, Wang T, He K, Li P, Wu X.

PI3K inhibition protects mice from NAFLD by down-regulating CMKLR1 and NLRP3 in Kupffer cells.

J Physiol Biochem

2017 Nov;73(4):583-594.

(IF 2.952)

537. Zhang B, Shang P, Tao Z, Qiangba Y, Wang Z, Zhang H.

Effect of a single nucleotide polymorphism in the growth hormone secretagogue receptor (GHSR) gene on growth rate in pigs.

Gene

2017 Nov 15;634:68-73.

(IF 2.984)

538. Yang YS, Yuan Y, Hu WP, Shang QX, Chen LQ.

The role of mitochondrial folate enzyme MTHFD1L in esophageal squamous cell carcinoma.

SCAND J GASTROENTERO

2017 Nov 24:1-8.

(IF 2.13)

539. Guo J, Guo S, Wang Y, Yu Y.

Promoting potential of adipose derived stem cells on peripheral nerve regeneration.

Mol Med Rep

2017 Nov;16(5):7297-7304.

(IF 2.1)

540. Qiao L, Liu X, Tang Y, Zhao Z, Zhang J, Feng Y.

Down regulation of the long non-coding RNA PCAT-1 induced growth arrest and apoptosis of colorectal cancer cells.

Life Sci

2017 Nov 1;188:37-44.

(IF 3.647)

541. Zhang B, Xu L, Zhuo N, Shen J.

Resveratrol protects against mitochondrial dysfunction through autophagy activation in human nucleus pulposus cells.

BIOCHEM BIOPH RES CO

2017 Nov 4;493(1):373-381.

(IF 2.985)

542. Zou L, Li X, Wu N, Jia P, Liu C, Jia D.

Palmitate induces myocardial lipotoxic injury via the endoplasmic reticulum stress‑mediated apoptosis pathway.

Mol Med Rep

2017 Nov;16(5):6934-6939.

(IF 2.1)

543. Huang Z, Yi X, Chen Y, Hou X, Wang X, Zhu P, Zhao K, Wu S, Fu N, Liu B.

Pretreatment of Pam3CSK4 attenuates inflammatory responses caused by systemic infection of methicillin-resistant Staphylococcus aureus in mice.

Biomed Pharmacother

2017 Nov;95:1684-1692.

(IF 4.545)

544. Zhao Y, He L, Zhang Y, Zhao J, Liu Z, Xing F, Liu M, Feng Z, Li W, Zhang J.

Estrogen receptor alpha and beta regulate actin polymerization and spatial memory through an SRC-1/mTORC2-dependent pathway in the hippocampus of female mice.

J STEROID BIOCHEM

2017 Nov;174:96-113.

(IF 3.813)

545. Gong P, Deng F, Zhang W, Ji J, Liu J, Sun Y, Hu J.

Tectorigenin attenuates the MPP+-induced SH-SY5Y cell damage, indicating a potential beneficial role in Parkinson's disease by oxidative stress inhibition.

Exp Ther Med

2017 Nov;14(5):4431-4437.

(IF 1.785)

546. Wu X, Liang M, Yang Z, Su M, Yang B.

Effect of acute exposure to PFOA on mouse liver cells in vivo and in vitro.

ENVIRON SCI POLLUT R

2017 Nov;24(31):24201-24206.

(IF 3.056)

547. Guo M, Zhao X, Yuan X, Li P.

Elevated microRNA-34a contributes to trophoblast cell apoptosis in preeclampsia by targeting BCL-2.

J Hum Hypertens

2017 Dec;31(12):815-820.

(IF 2.26)

548. Li S, Zhao H, Wang Y, Shao Y, Li J, Liu J, Xing M.

The inflammatory responses in Cu-mediated elemental imbalance is associated with mitochondrial fission and intrinsic apoptosis in Gallus gallus heart.

Chemosphere

2017 Dec;189:489-497.

(IF 5.778)

549. Fu X, Xie W, Song X, Wu K, Xiao L, Liu Y, Zhang L.

Aberrant expression of deubiquitylating enzyme USP9X predicts poor prognosis in gastric cancer.

CLIN RES HEPATOL GAS

2017 Dec;41(6):687-692.

(IF 2.718)

550. Zhang W, Wei R, Zhang L, Tan Y, Qian C.

Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation.

Neuroscience

2017 Dec 16;366:95-104.

(IF 3.056)

551. Zhao T, Bai J, Zou Q, Chen F, Xie Y.

Insulin in combination with cisplatin induces the apoptosis of ovarian cancer cells via p53 and JNK activation.

Mol Med Rep

2017 Dec;16(6):9095-9101.

(IF 2.1)

552. Ren A, Fu G, Qiu Y, Cui H.

Leflunomide inhibits proliferation and tumorigenesis of oral squamous cell carcinoma.

Mol Med Rep

2017 Dec;16(6):9125-9130.

(IF 2.1)

553. Gu YP, Yang XM, Duan ZH, Luo P, Shang JH, Xiao W, Tao YX, Zhang DY, Zhang YB, Liu HZ.

Inhibition of chemotherapy-induced apoptosis of testicular cells by squid ink polysaccharide.

Exp Ther Med

2017 Dec;14(6):5889-5895.

(IF 1.785)

554. Ye W, Zhang C, Xu N, Sun Y, Ma L, Shen B, Zhou D, Zhu C.

Carbonic anhydrase II confers resistance to deltamethrin in Culex pipiens pallens.

ARCH INSECT BIOCHEM

2017 Dec;96(4).

(IF 1.536)

555. Zheng F, Yang Y, Lu S, Yang Q, Li Y, Xu X, Zhang Y, Liu F, Tian X, Wang X.

CD36 Deficiency Suppresses Epileptic Seizures.

Neuroscience

2017 Dec 26;367:110-120.

(IF 3.056)

556. Yao L, Wang J, Tian BY, Xu TH, Sheng ZT.

Activation of the Nrf2-ARE Signaling Pathway Prevents Hyperphosphatemia-Induced Vascular Calcification by Inducing Autophagy in Renal Vascular Smooth Muscle Cells.

J Cell Biochem

2017 Dec;118(12):4708-4715.

(IF 4.237)

557. Zhang H, Nan W, Song X, Wang S, Si H, Li G.

Knockdown of HIF-1α inhibits the proliferation and migration of outer root sheath cells exposed to hypoxia in vitro: An involvement of Shh pathway.

Life Sci

2017 Dec 15;191:82-89.

(IF 3.647)

558. Li R, Luo X, Zhu Y, Zhao L, Li L, Peng Q, Ma M, Gao Y.

ATM signals to AMPK to promote autophagy and positively regulate DNA damage in response to cadmium-induced ROS in mouse spermatocytes.

Environ Pollut

2017 Dec;231(Pt 2):1560-1568.

(IF 6.792)

559. Zhang D, Xu XL, Li F, Sun HC, Cui YQ, Liu S, Xu PY.

Upregulation of the checkpoint protein CHFR is associated with tumor suppression in pancreatic cancers.

Oncol Lett

2017 Dec;14(6):8042-8050.

(IF 2.311)

560. Zhou J, Zhu YF, Chen XY, Han B, Li F, Chen JY, Peng XL, Luo LP, Chen W, Yu XP.

Black rice-derived anthocyanins inhibit HER-2-positive breast cancer epithelial-mesenchymal transition-mediated metastasis in vitro by suppressing FAK signaling.

Int J Mol Med

2017 Dec;40(6):1649-1656.

(IF 3.098)

561. Liu S, Yi F, Cheng W, Qu X, Wang C.

Molecular mechanisms in vascular injury induced by hypertension: Expression and role of microRNA-34a.

Exp Ther Med

2017 Dec;14(6):5497-5502.

(IF 1.785)

562. Li X, Wu Z, Zhang Y, Xu Y, Han G, Zhao P.

Activation of Autophagy Contributes to Sevoflurane-Induced Neurotoxicity in Fetal Rats.

Front Mol Neurosci

2017 Dec 22;10:432.

(IF 4.057)

563. Zhang WJ, Wang HH, Lv YD, Liu CC, Sun WY, Tian LJ.

Downregulation of Egr-1 Expression Level via GluN2B Underlies the Antidepressant Effects of Ketamine in a Chronic Unpredictable Stress Animal Model of Depression.

Neuroscience

2017 Dec 30;372:38-45.

(IF 3.056)

564. Lang L, Zhang Z, Jing W, Hwang JS, Lee SC, Wang L.

Identification of a novel toll gene (Shtoll3) from the freshwater crab Sinopotamon henanense and its expression pattern changes in response to cadmium followed by Aeromonas hydrophila infection.

FISH SHELLFISH IMMUN

2017 Dec;71:177-190.

(IF 3.298)

565. Jiang KL, Zhong L, Yang XQ, Ma PP, Wang H, Zhu XY, Liu BZ.

NLS-RARα is a novel transcriptional factor.

Oncol Lett

2017 Dec;14(6):7091-7098.

(IF 2.311)

566. Zhao X, Xing F, Cong Y, Zhuang Y, Han M, Wu Z, Yu S, Wei H, Wang X, Chen G.

Antimony trichloride induces a loss of cell viability via reactive oxygen species-dependent autophagy in A549 cells.

INT J BIOCHEM CELL B

2017 Dec;93:32-40.

(IF 3.673)

567. Li X, Wu N, Zou L, Jia D.

Protective effect of celastrol on myocardial ischemia-reperfusion injury.

Anatol J Cardiol

2017 Dec;18(6):384-390.

(IF 1.223)

568. Wang N, Yang L, Zhang H, Lu X, Wang J, Cao Y, Chen L, Wang X, Cong L, Li J, Wang N, Liu Z, Wang L.

MicroRNA-9a-5p Alleviates Ischemia Injury After Focal Cerebral Ischemia of the Rat by Targeting ATG5-Mediated Autophagy.

CELL PHYSIOL BIOCHEM

2017 Dec 22;45(1):78-87.

(IF 5.5)

569. Guo W, Lian S, Zhen L, Zang S, Chen Y, Lang L, Xu B, Guo J, Ji H, Wang J, Fu S, Zhang L, Yang H

The Favored Mechanism for Coping with Acute Cold Stress: Upregulation of miR-210 in Rats.

CELL PHYSIOL BIOCHEM.

2018;46(5):2090-2102.

(IF 5.5)

570. He L, Meng Y, Zhang Z, Liu Y, Wang X

Downregulation of basic fibroblast growth factor increases cisplatin sensitivity in A549 non-small cell lung cancer cells.

J Cancer Res Ther.

2018;14(7):1519-1524.

(IF 1.326)

571. Chen Y, Zhao J, Li D, Hao J, He P, Wang H, Zhang M

TRIM56 Suppresses Multiple Myeloma Progression by Activating TLR3/TRIF Signaling.

Yonsei Med J.

2018 Jan;59(1):43-50.

(IF 1.914)

572. Li H, Yang Q, Han X, Tan X, Qin J, Jin G

Low-dose DHA-induced astrocyte proliferation can be attenuated by insufficient expression of BLBP in vitro.

PROSTAG OTH LIPID M.

2018 Jan;134:114-122.

(IF 2.283)

573. Jiang LB, Cao L, Ma YQ, Chen Q, Liang Y, Yuan FL, Li XL, Dong J, Chen N

TIGAR mediates the inhibitory role of hypoxia on ROS production and apoptosis in rat nucleus pulposus cells.

OSTEOARTHR CARTILAGE.

2018 Jan;26(1):138-148.

(IF 4.793)

574. Tao P, Wen H, Yang B, Zhang A, Wu X, Li Q

miR-144 inhibits growth and metastasis of cervical cancer cells by targeting VEGFA and VEGFC.

Exp Ther Med.

2018 Jan;15(1):562-568.

(IF 1.785)

575. Maryam A, Mehmood T, Yan Q, Li Y, Khan M, Ma T

Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.

Oxid Med Cell Longev.

2018 Jan 11;2018:3853409.

(IF 5.076)

576. Wang J, Zhai W, Yu Z, Sun L, Li H, Shen H, Li X, Liu C, Chen G.

Neuroprotection Exerted by Netrin-1 and Kinesin Motor KIF1A in Secondary Brain Injury following Experimental Intracerebral Hemorrhage in Rats.

Front Cell Neurosci

2018 Jan 11;11:432.

(IF 3.921)

577. Dong J, Qu Y, Li J, Cui L, Wang Y, Lin J, Wang H.

Cortisol inhibits NF-κB and MAPK pathways in LPS activated bovine endometrial epithelial cells.

Int Immunopharmacol

2018 Jan 20;56:71-77.

(IF 3.943)

578. Cao B, Yang S, Li W, Chen H, Chen Y, Liu Y, Liu B.

GMZ-1 is a podophyllotoxin derivative that suppresses growth and induces apoptosis in adriamycin-resistant K562/A02 cells through modulation of MDR1 expression.

Mol Med Rep

2018 Jan;17(1):474-478.

(IF 2.1)

579. Li S, Wang T, Zhai L, Ge K, Zhao J, Cong W, Guo Y.

Picroside II Exerts a Neuroprotective Effect by Inhibiting mPTP Permeability and EndoG Release after Cerebral Ischemia/Reperfusion Injury in Rats.

J Mol Neurosci

2018 Jan;64(1):144-155.

(IF 2.678)

580. Peng X, He J, Zhao J, Wu Y, Shi X, Du L, Nong M, Zong S, Zeng G

Polygonatum Sibiricum Polysaccharide Promotes Osteoblastic Differentiation Through the ERK/GSK-3β/β-Catenin Signaling Pathway In Vitro.

REJUV RES.

2018 Feb;21(1):44-52.

(IF 3.811)

581. Xiang P, He RW, Liu RY, Li K, Gao P, Cui XY, Li H, Liu Y, Ma LQ

Cellular responses of normal (HL-7702) and cancerous (HepG2) hepatic cells to dust extract exposure.

Chemosphere.

2018 Feb;193:1189-1197.

(IF 5.778)

582. Wang Z, Li C, Jiang M, Chen J, Yang M, Pu J.

Filamin A (FLNA) regulates autophagy of bladder carcinoma cell and affects its proliferation, invasion and metastasis.

Int Urol Nephrol

2018 Feb;50(2):263-273.

(IF 1.843)

583. Niu M, Ma F, Qian J, Li J, Wang T, Gao Y, Jin J.

N‑cadherin attenuates nucleus pulposus cell senescence under high‑magnitude compression.

Mol Med Rep

2018 Feb;17(2):2879-2884.

(IF 2.1)

584. Li Y, Hong L, Liu C, Min J, Hong S, Hu M, Zhao Y, Yang Q, Tang J, He S.

Effect of puerarin on collagen metabolism of fibroblasts in pelvic tissue of women with pelvic organ prolapse.

Mol Med Rep

2018 Feb;17(2):2705-2711.

(IF 2.1)

585. Chang G, Liu J, Qin S, Jiang Y, Zhang P, Yu H, Lu K, Zhang N, Cao L, Wang Y, Li Y, Zhang D

Cardioprotection by exenatide: A novel mechanism via improving mitochondrial function involving the GLP-1 receptor/cAMP/PKA pathway.

Int J Mol Med.

2018 Mar;41(3):1693-1703.

(IF 3.098)

586. Li Y, Ye Y, Chen H

Astragaloside IV inhibits cell migration and viability of hepatocellular carcinoma cells via suppressing long noncoding RNA ATB.

Biomed Pharmacother.

2018 Mar;99:134-141.

(IF 4.545)

587. Ma L, Feng L, Ding X, Li Y

Effect of TLR4 on the growth of SiHa human cervical cancer cells via the MyD88-TRAF6-TAK1 and NF-κB-cyclin D1-STAT3 signaling pathways.

Oncol Lett.

2018 Mar;15(3):3965-3970.

(IF 2.311)

588. Chen ZW, Miu HF, Wang HP, Wu ZN, Wang WJ, Ling YJ, Xu XH, Sun HJ, Jiang X

Pterostilbene protects against uraemia serum-induced endothelial cell damage via activation of Keap1/Nrf2/HO-1 signaling.

Int Urol Nephrol.

2018 Mar;50(3):559-570.

(IF 1.843)

589. Wang W, Qing X, Wang B, Ma K, Wei Y, Shao Z

Tauroursodeoxycholic Acid Protects Nucleus Pulposus Cells from Compression-Induced Apoptosis and Necroptosis via Inhibiting Endoplasmic Reticulum Stress.

EVID-BASED COMPL ALT.

2018 Mar 12;2018:6719460.

(IF 1.813)

590. Sun L, Dong Y, Zhao J, Yin Y, Tong B, Zheng Y, Xin H.

NPPB modulates apoptosis, proliferation, migration and extracellular matrix synthesis of conjunctival fibroblasts by inhibiting PI3K/AKT signaling.

Int J Mol Med

2018 Mar;41(3):1331-1338.

(IF 3.098)

591. Yu C, Lixia Y, Ruiwei G, Yankun S, Jinshan Y

The Role of FAK in the Secretion of MMP9 after CD147 Stimulation in Macrophages.

Int Heart J.

2018 Mar 30;59(2):394-398.

(IF 1.906)

592. Deng Y, Ma W.

Metformin inhibits HaCaT cell viability via the miR-21/PTEN/Akt signaling pathway.

Mol Med Rep

2018 Mar;17(3):4062-4066. doi: 10.3892/mmr.2017.8364. Epub 2017 Dec 27.

(IF 2.1)

593. Wu J, Du W, Wang X, Wei L, Pan Y, Wu X, Zhang J, Pei D

Ras-related protein Rap2c promotes the migration and invasion of human osteosarcoma cells.

Oncol Lett.

2018 Apr;15(4):5352-5358.

(IF 2.311)

594. Fu H, Li X, Tan J

NIPAAm-MMA nanoparticle-encapsulated visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis.

Oncol Lett.

2018 Apr;15(4):4827-4836.

(IF 2.311)

595. Hu YH, Chen XM, Yang P, Ding WF

Characterization and functional assay of a fatty acyl-CoA reductase gene in the scale insect, Ericerus pela Chavannes (Hemiptera: Coccoidae).

ARCH INSECT BIOCHEM.

2018 Apr;97(4).

(IF 1.536)

596. Zhu H, Huang Y, Su H, Ma Y, Tao Y, Liao DJ, Liu Y, Feng Z

Identification of a novel human estrogen receptor-α splice variant able to enhance malignant biological behaviors of breast cancer cells.

Oncol Lett.

2018 Apr;15(4):5339-5344.

(IF 2.311)

597. Liu L, Wu W, Li J, Jiao WH, Liu LY, Tang J, Liu L, Sun F, Han BN, Lin HW

Two sesquiterpene aminoquinones protect against oxidative injury in HaCaT keratinocytes via activation of AMPKα/ERK-Nrf2/ARE/HO-1 signaling.

Biomed Pharmacother.

2018 Apr;100:417-425.

(IF 4.545)

598. Zhang H, Pang Y, Ma C, Li J, Wang H, Shao Z

ClC5 Decreases the Sensitivity of Multiple Myeloma Cells to Bortezomib via Promoting Prosurvival Autophagy.

Oncol Res.

2018 Apr 10;26(3):421-429.

(IF 4.949)

599. Chen ZJ, Ma F, Sun XM, Zhao XS, Luo R

Renoprotective Effect of a Chinese Herbal Formula, Qidan Dihuang Decoction, on Streptozotocin-Induced Diabetes in Rat.

EVID-BASED COMPL ALT.

2018 Apr 12;2018:7321086.

(IF 1.813)

600. Huang WJ, Wang Y, Liu S, Yang J, Guo SX, Wang L, Wang H, Fan YF.

Silencing circular RNA hsa_circ_0000977 suppresses pancreatic ductal adenocarcinoma progression by stimulating miR-874-3p and inhibiting PLK1 expression.

Cancer Lett.

422:70-80.

(IF 7.36)

601. Xinyu Zhang, Lei Han, Huifang Zong, Kai Ding, Yuan Yuan, Jingyi Bai, Yuexian Zhou, Baohong Zhang, Jianwei Zhu

Enhanced Production of anti-PD1 Antibody in CHO Cells Through Transient Co-Transfection With Anti-Apoptotic Genes Bcl-x L and Mcl-1

Bioprocess Biosyst Eng.

doi: 10.1007/s00449-018-1898-z.

602. Cai J, Jiang Y, Zhang M, Zhao H, Li H, Li K, Zhang X, Qiao T

Protective effects of mitochondrion-targeted peptide SS-31 against hind limb ischemia-reperfusion injury.

J Physiol Biochem.

2018 May;74(2):335-343.

(IF 2.952)

603. Qiao H, Zhou Y, Qin X, Cheng J, He Y, Jiang Y

NADPH Oxidase Signaling Pathway Mediates Mesenchymal Stem Cell-Induced Inhibition of Hepatic Stellate Cell Activation.

Stem Cells Int.

2018 May 10;2018:1239143.

(IF 3.869)

604. Wang M, Huang Y, He M, Peng WJ, Tian DY

Effects of hepatitis E virus infection on interferon production via ISG15.

WORLD J GASTROENTERO.

2018 May 28;24(20):2173-2180.

(IF 3.665)

605. Jia P, Liu C, Wu N, Jia D, Sun Y

Agomelatine protects against myocardial ischemia reperfusion injury by inhibiting mitochondrial permeability transition pore opening.

Am J Transl Res

2018 May 15;10(5):1310-1323. eCollection 2018.

(IF 3.375)

606. Chen S, Lv X, Hu B, Zhao L, Li S, Li Z, Qing X, Liu H, Xu J, Shao Z

Critical contribution of RIPK1 mediated mitochondrial dysfunction and oxidative stress to compression-induced rat nucleus pulposus cells necroptosis and apoptosis.

Apoptosis.

2018 Jun;23(5-6):299-313.

(IF 4.543)

607. Liu ZC, Wang ZL, Huang CY, Fu ZJ, Liu Y, Wei ZC, Liu SG, Ma C, Shen JL, Duan DD

Duhuo Jisheng Decoction inhibits SDF-1-induced inflammation and matrix degradation in human degenerative nucleus pulposus cells in vitro through the CXCR4/NF-κB pathway.

Acta Pharmacol Sin.

2018 Jun;39(6):912-922.

(IF 5.064)

608. Wang Y, Jiang S, Xiao J, Liang Q, Tang M

Sparstolonin B improves neurological outcomes following intracerebral hemorrhage in mice.

Exp Ther Med.

2018 Jun;15(6):5436-5442.

(IF 1.785)

609. Xiao Y, Li B, Liu J

MicroRNA‑148a inhibition protects against ovariectomy‑induced osteoporosis through PI3K/AKT signaling by estrogen receptor α.

Mol Med Rep.

2018 Jun;17(6):7789-7796.

(IF 2.1)

610. Li Y, Gong Q, Guo W, Kan X, Xu D, Ma H, Fu S, Liu J

Farrerol Relieve Lipopolysaccharide (LPS)-Induced Mastitis by Inhibiting AKT/NF-κB p65, ERK1/2 and P38 Signaling Pathway.

Int J Mol Sci.

2018 Jun 14;19(6). pii: E1770.

(IF 4.556)

611. Wang Y, Wang S, Liu J, Lu Y, Li D

Licoricidin enhances gemcitabine-induced cytotoxicity in osteosarcoma cells by suppressing the Akt and NF-κB signal pathways.

CHEM-BIOL INTERACT.

2018 Jun 25;290:44-51.

(IF 3.723)

612. Jin C, Liu X, Tan L, Cui Z, Yang X, Zheng Y, Yeung KWK, Chu PK, Wu S

Ag/AgBr-loaded mesoporous silica for rapid sterilization and promotion of wound healing.

BIOMATER SCI-UK.

2018 Jun 25;6(7):1735-1744.

(IF 6.183)

613. Lu YT, Li LZ, Yang YL, Yin X, Liu Q, Zhang L, Liu K, Liu B, Li J, Qi LW

Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling.

Cell Death Dis.

2018 Jun 4;9(6):672.

(IF 6.304)

614. Xing FZ, Zhao YG, Zhang YY, He L, Zhao JK, Liu MY, Liu Y, Zhang JQ.

Nuclear and membrane estrogen receptor antagonists induce similar mTORC2 activation-reversible changes in synaptic protein expression and actin polymerization in the mouse hippocampus.

CNS Neurosci Ther

2018 Jun;24(6):495-507.

(IF 4.074)

615. Li S, Cao H, Shen D, Jia Q, Chen C, Xing SL

Quercetin protects against ox‑LDL‑induced injury via regulation of ABCAl, LXR‑α and PCSK9 in RAW264.7 macrophages.

Mol Med Rep.

2018 Jul;18(1):799-806.

(IF 2.1)

616. Pan J, Huang C, Chen G, Cai Z, Zhang Z

MicroRNA-451 blockade promotes osteoblastic differentiation and skeletal anabolic effects by promoting YWHAZ-mediated RUNX2 protein stabilization.

Medchemcomm.

2018 Jul 10;9(8):1359-1368.

(IF 2.807)

617. Li Z, Chen S, Ma K, Lv X, Lin H, Hu B, He R, Shao Z

CsA attenuates compression-induced nucleus pulposus mesenchymal stem cells apoptosis via alleviating mitochondrial dysfunction and oxidative stress.

Life Sci.

2018 Jul 15;205:26-37.

(IF 3.647)

618. Zhou D, Duan B, Xu Y, Ma L, Shen B, Sun Y, Zhu C

NYD-OP7/PLC regulatory signaling pathway regulates deltamethrin resistance in Culex pipiens pallens (Diptera: Culicidae).

PARASITE VECTOR.

2018 Jul 16;11(1):419.

(IF 2.824)

619. Huang C, Gan D, Fan C, Wen C, Li A, Li Q, Zhao J, Wang Z, Zhu L, Lu D

The Secretion from Neural Stem Cells Pretreated with Lycopene Protects against tert-Butyl Hydroperoxide-Induced Neuron Oxidative Damage.

Oxid Med Cell Longev.

2018 Jul 22;2018:5490218.

(IF 5.076)

620. Li L, Wan G, Han B, Zhang Z

Echinacoside alleviated LPS-induced cell apoptosis and inflammation in rat intestine epithelial cells by inhibiting the mTOR/STAT3 pathway.

Biomed Pharmacother.

2018 Aug;104:622-628.

(IF 4.545)

621. Xu H, Xie J, Lei Y, Cui Q, Jin M

[Anti-inflammatory effects of penehyclidine hydrochloride on acute respiratory distress syndrome in rats].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue.

2018 Aug;30(8):764-767.

622. Xiu G, Sui X, Wang Y, Zhang Z

FOXM1 regulates radiosensitivity of lung cancer cell partly by upregulating KIF20A.

Eur J Pharmacol.

2018 Aug 15;833:79-85.

(IF 3.263)

623. Wang YD, Sun XJ, Yang WJ, Li J, Yin JJ

Magnolol exerts anticancer activity in hepatocellular carcinoma cells through regulating endoplasmic reticulum stress-mediated apoptotic signaling.

ONCOTARGETS THER.

2018 Aug 28;11:5219-5226.

(IF 3.337)

624. Huixian Xu, Jing Xie, Yanna Lei, Qingsong Cui, Minggen Jin

[Anti-inflammatory Effects of Penehyclidine Hydrochloride on Acute Respiratory Distress Syndrome in Rats]

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue.

doi: 10.3760/cma.j.issn.2095-4352.2018.08.010.

625. Chen Q, Pan Z, Zhao M, Wang Q, Qiao C, Miao L, Ding X.

High cholesterol in lipid rafts reduces the sensitivity to EGFR-TKI therapy in non-small cell lung cancer.

J Cell Physiol

2018 Sep;233(9):6722-6732.

(IF 5.546)

626. Huang X, Wang Z, Li D, Huang Z, Dong X, Li C, Lan J

Study of microRNAs targeted Dvl2 on the osteoblasts differentiation of rat BMSCs in hyperlipidemia environment.

J Cell Physiol.

2018 Sep;233(9):6758-6766.

(IF 5.546)

627. Zhu H, Zheng T, Yu J, Zhou L, Wang L

LncRNA XIST accelerates cervical cancer progression via upregulating Fus through competitively binding with miR-200a.

Biomed Pharmacother.

2018 Sep;105:789-797.

(IF 4.545)

628. Pei G, Li B, Ma A

Suppression of Hiwi inhibits the growth and epithelial-mesenchymal transition of cervical cancer cells.

Oncol Lett.

2018 Sep;16(3):3874-3880.

(IF 2.311)

629. Zhou Y, Liu H, Song J, Cao L, Tang L, Qi C

Sinomenine alleviates dextran sulfate sodium‑induced colitis via the Nrf2/NQO‑1 signaling pathway.

Mol Med Rep.

2018 Oct;18(4):3691-3698.

(IF 2.1)

630. Zhang X, Yang Y, Feng Z

Suppression of microRNA-495 alleviates high-glucose-induced retinal ganglion cell apoptosis by regulating Notch/PTEN/Akt signaling.

Biomed Pharmacother.

2018 Oct;106:923-929.

(IF 4.545)

631. Liu Y, Ren L, Liu W, Xiao Z

MiR-21 regulates the apoptosis of keloid fibroblasts by caspase-8 and the mitochondria-mediated apoptotic signaling pathway via targeting FasL.

Biochem Cell Biol.

2018 Oct;96(5):548-555.

(IF 2.46)

632. Zhang XW, Wang S, Tu PF, Zeng KW

Sesquiterpene lactone from Artemisia argyi induces gastric carcinoma cell apoptosis via activating NADPH oxidase/reactive oxygen species/mitochondrial pathway.

Eur J Pharmacol.

2018 Oct 15;837:164-170.

(IF 3.263)

633. Lu C, Chen X, Wang Q, Xu X, Xu B

TNFα promotes glioblastoma A172 cell mitochondrial apoptosis via augmenting mitochondrial fission and repression of MAPK-ERK-YAP signaling pathways.

ONCOTARGETS THER.

2018 Oct 18;11:7213-7227.

(IF 3.337)

634. Wang Y, Shen J, Chen Y, Liu H, Zhou H, Bai Z, Hu Z, Guo X

PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy.

BIOCHEM BIOPH RES CO.

2018 Oct 2;504(2):406-414.

(IF 2.985)

635. Liu Q, Hu Y, Zhang M, Yan Y, Yu H, Ge L

microRNA-451 protects neurons against ischemia/reperfusion injury-induced cell death by targeting CELF2.

Neuropsychiatr Dis Treat.

2018 Oct 23;14:2773-2782.

636. Liu F, Wang Z, Liu F, Xu J, Liu Q, Yin K, Lan J

MicroRNA-29a-3p enhances dental implant osseointegration of hyperlipidemic rats via suppressing dishevelled 2 and frizzled 4.

Cell Biosci.

2018 Oct 26;8:55.

(IF 5.026)

637. Wang Y, Chen Y, Chen Y, Zhou B, Shan X, Yang G

Eriodictyol inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes.

Biomed Pharmacother.

2018 Nov;107:1128-1134.

(IF 4.545)

638. Luo J, Song J, Zhang H, Zhang F, Liu H, Li L, Zhang Z, Chen L, Zhang M, Lin D, Lin M, Zhou R

Melatonin mediated Foxp3-downregulation decreases cytokines production via the TLR2 and TLR4 pathways in H. pylori infected mice.

Int Immunopharmacol.

2018 Nov;64:116-122.

(IF 3.943)

639. Yao S, Yan W

Overexpression of Mst1 reduces gastric cancer cell viability by repressing the AMPK-Sirt3 pathway and activating mitochondrial fission.

ONCOTARGETS THER.

2018 Nov 29;11:8465-8479.

(IF 3.337)

640. Li Z, Wang Y, Hu R, Xu R, Xu W

LncRNA B4GALT1-AS1 recruits HuR to promote osteosarcoma cells stemness and migration via enhancing YAP transcriptional activity.

CELL PROLIFERAT.

2018 Dec;51(6):e12504.

(IF 5.753)

641. Huang H, Tang J, Zhang L, Bu Y, Zhang X

miR-874 regulates multiple-drug resistance in gastric cancer by targeting ATG16L1.

Int J Oncol.

2018 Dec;53(6):2769-2779.

(IF 3.899)

642. Wang Y, Hai B, Ai L, Cao Y, Li R, Li H, Li Y

Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress.

Iran J Basic Med Sci.

2018 Dec;21(12):1238-1244.

(IF 2.146)

643. Yue Q, Zhao C, Wang Y, Zhao L, Zhu Q, Li G, Wu N, Jia D, Ma C

Downregulation of growth arrest‑specific transcript 5 alleviates palmitic acid‑induced myocardial inflammatory injury through the miR‑26a/HMGB1/NF‑κB axis.

Mol Med Rep.

2018 Dec;18(6):5742-5750.

(IF 2.1)

644. Cheng C, Xie Z, Li Y, Wang J, Qin C, Zhang Y

PTBP1 knockdown overcomes the resistance to vincristine and oxaliplatin in drug-resistant colon cancer cells through regulation of glycolysis.

Biomed Pharmacother.

2018 Dec;108:194-200.

(IF 4.545)

645. Zheng Z, Zhou X, Cai Y, Chen E, Zhang X, Wang O, Wang Q, Liu H

TEKT4 Promotes Papillary Thyroid Cancer Cell Proliferation, Colony Formation, and Metastasis through Activating PI3K/Akt Pathway.

Endocr Pathol.

2018 Dec;29(4):310-316.

(IF 3.168)

646. Yuan Z, Li Y, Zhao D, Zhang K, Wang F, Wang C, Wen Y

High efficiency 3D nanofiber sponge for bilirubin removal used in hemoperfusion.

COLLOID SURFACE B.

2018 Dec 1;172:161-169.

(IF 4.389)

647. Li X, Ning L, Zhao X, Wan S

MicroRNA-543 promotes ovariectomy-induced osteoporosis through inhibition of AKT/p38 MAPK signaling pathway by targeting YAF2.

J Cell Biochem.

2018 Dec 2.

(IF 4.237)

648. Shen X, Gao X, Li H, Gu Y, Wang J

TIMP-3 Increases the Chemosensitivity of Laryngeal Carcinoma to Cisplatin via Facilitating Mitochondria-Dependent Apoptosis.

Oncol Res.

2018 Dec 27;27(1):73-80.

(IF 4.949)

649. Ruixi Hu, Xiaodong Zhu, Chao Chen, Ruijun Xu, Yifan Li, Wei Xu

RNA-binding Protein PUM2 Suppresses Osteosarcoma Progression via Partly and Competitively Binding to STARD13 3'UTR With miRNAs

CELL PROLIFERAT.

doi: 10.1111/cpr.12508.

(IF 5.753)

650. Wu N, Zhang X, Du S, Chen D, Che R

Upregulation of miR-335 ameliorates myocardial ischemia reperfusion injury via targeting hypoxia inducible factor 1-alpha subunit inhibitor.

Am J Transl Res

2018 Dec 15;10(12):4082-4094. eCollection 2018.

(IF 3.375)

651. Liu Z, Li H, Fan S, Lin H, Lian W

STAT3-induced upregulation of long noncoding RNA HNF1A-AS1 promotes the progression of oral squamous cell carcinoma via activating Notch signaling pathway.

Cancer Biol Ther.

20(4):444-453.

(IF 3.659)

652. Chang P, Zhang M, Zhang X, Li G, Hu H, Wu J, Wang X, Yang Z, Zhang J, Chen W, Ren M, Li X, Zhu M, Chen B, Yu J

B-type natriuretic peptide attenuates endoplasmic reticulum stress in H9c2 cardiomyocytes underwent hypoxia/reoxygenation injury under high glucose/high fat conditions.

Peptides.

111:103-111.

(IF 2.843)

653. Wei Z, Sun W, Tran NT, Gong Y, Ma H, Zheng H, Zhang Y, Li S

Two novel serine proteases from Scylla paramamosain involved in the synthesis of anti-lipopolysaccharide factors and activation of prophenoloxidase system.

FISH SHELLFISH IMMUN.

84:322-332.

(IF 3.298)

654. Miao J, Huang Z, Liu S, Li X, Jia P, Guo Y, Wu N, Jia D

Hydroxytyrosol protects against myocardial ischemia reperfusion injury by inhibiting mitochondrial permeability transition pore opening.

Exp Ther Med.

17(1):671-678.

(IF 1.785)

655. Jun-Sheng Ni, Hao Zheng, Zhi-Ping Huang, Yong-Gang Hong, Yang-Liu Ou, Yuan-Ping Tao, Meng-Chao Wang, Zhen-Guang Wang, Yuan Yang, Wei-Ping Zhou

MicroRNA-197-3p Acts as a Prognostic Marker and Inhibits Cell Invasion in Hepatocellular Carcinoma

Oncol Lett.

doi: 10.3892/ol.2018.9848.

(IF 2.311)

656. Li W, Jiang LJ, Zhou XJ, Lu XZ, Liu LF, Wang S

Association of the invasiveness of colon cancer with the expression of C/EBPα.

Oncol Lett.

17(2):1974-1979.

(IF 2.311)

657. Guo W, Liu B, Hu G, Kan X, Li Y, Gong Q, Xu D, Ma H, Cao Y, Huang B, Fu S, Liu J

Vanillin protects the blood-milk barrier and inhibits the inflammatory response in LPS-induced mastitis in mice.

TOXICOL APPL PHARM .

365:9-18.

(IF 3.616)

658. Liang X, Wu K, Liu M, Yang B

Adverse impact of carbon tetrachloride on metabolic function in mice.

J Cell Biochem.

(IF 4.237)

659. Liu B, Ji J, Feng Q, Luo X, Yan X, Ni Y, He Y, Mao Z, Liu J

Monosialoganglioside protects against bupivacaine-induced neurotoxicity caused by endoplasmic reticulum stress in rats.

DRUG DES DEV THER.

13:707-718.

(IF 3.216)

660. Wang Z, Shi Z, Zhang L, Zhang H, Zhang Y

Profilin 1, negatively regulated by microRNA-19a-3p, serves as a tumor suppressor in human hepatocellular carcinoma.

Pathol Res Pract.

2019 Mar;215(3):499-505.

(IF 2.05)

661. Dong M, Xie Y, Xu Y

miR-7-5p regulates the proliferation and migration of colorectal cancer cells by negatively regulating the expression of Krüppel-like factor 4.

Oncol Lett.

17(3):3241-3246.

(IF 2.311)

662. Du ZD, Yu S, Qi Y, Qu TF, He L, Wei W, Liu K, Gong SS

NADPH oxidase inhibitor apocynin decreases mitochondrial dysfunction and apoptosis in the ventral cochlear nucleus of D-galactose-induced aging model in rats.

Neurochem Int.

124:31-40.

(IF 3.881)

663. Yi J, Mei L, Li X, Zheng W, Li Y, Zhao Z

Effects of continuous and intermittent parathyroid hormone administration on midpalatal suture expansion in rats.

Arch Oral Biol.

99:161-168.

(IF 1.931)

664. Zhou J, Shi M, Li M, Cheng L, Yang J, Huang X

Sirtuin 3 inhibition induces mitochondrial stress in tongue cancer by targeting mitochondrial fission and the JNK-Fis1 biological axis.

CELL STRESS CHAPERON.

24(2):369-383.

(IF 2.892)

665. Bai Y, Wang W, Zhang Y, Zhang F, Zhang H

lncRNA MIAT suppression alleviates corneal angiogenesis through regulating miR-1246/ACE.

Cell Cycle.

18(6-7):661-669.

(IF 3.699)

666. Li JM, Liu LL, Su WJ, Wang B, Zhang T, Zhang Y, Jiang CL

Ketamine may exert antidepressant effects via suppressing NLRP3 inflammasome to upregulate AMPA receptors.

Neuropharmacology.

146:149-153.

(IF 4.431)

667. Gao X, Ming J, Liu S, Lai B, Fang F, Cang J

Sevoflurane enhanced the clearance of Aβ1-40 in hippocampus under surgery via up-regulating AQP-4 expression in astrocyte.

Life Sci.

221:143-151.

(IF 3.647)

668. Liu G, An L, Zhang H, Du P, Sheng Y

Activation of CXCL6/CXCR1/2 Axis Promotes the Growth and Metastasis of Osteosarcoma Cells in vitro and in vivo.

Front Pharmacol.

10:307.

(IF 4.225)

669. Di X, He G, Chen H, Zhu C, Qin Q, Yan J, Zhang X, Sun X

High-mobility group box 1 protein modulated proliferation and radioresistance in esophageal squamous cell carcinoma.

EUR J GASTROEN HEPAT.

34(4):728-735.

(IF 2.251)

670. Tan Z, Kang T, Zhang X, Tong Y, Chen S

Nerve growth factor prevents arsenic-induced toxicity in PC12 cells through the AKT/GSK-3β/NFAT pathway.

J Cell Physiol.

234(4):4726-4738.

(IF 5.546)

671. Zhuang J, Wang Y, Qu F, Wu Y, Zhao D, Xu C

Gasdermin-d Played a Critical Role in the Cyclic Stretch-Induced Inflammatory Reaction in Human Periodontal Ligament Cells.

Inflammation.

2019 Apr;42(2):548-558.

(IF 3.212)

672. Wang A, Wang J, Wu J, Deng X, Zou Y

Suramin protects hepatocytes from LPS-induced apoptosis by regulating mitochondrial stress and inactivating the JNK-Mst1 signaling pathway.

J Physiol Sci.

69(3):489-502.

(IF 2.955)

673. Wang Q, Wang J, Niu S, Wang S, Liu Y, Wang X

MicroRNA-664 targets paired box protein 6 to inhibit the oncogenicity of pancreatic ductal adenocarcinoma.

Int J Oncol.

54(5):1884-1896.

(IF 3.899)

674. Wang P, Liu X, Kong C, Liu X, Teng Z, Ma Y, Yong L, Liang C, He G, Lu S

Potential role of the IL17RC gene in the thoracic ossification of the posterior longitudinal ligament.

Int J Mol Med.

43(5):2005-2014.

(IF 3.098)

675. Song F, Wei M, Wang J, Liu Y, Guo M, Li X, Luo J, Zhou J, Wang M, Guo D, Chen L, Sun G

Hepatitis B virus-regulated growth of liver cancer cells occurs through the microRNA-340-5p-activating transcription factor 7-heat shock protein A member 1B axis.

Cancer Sci.

110(5):1633-1643.

(IF 4.966)

676. Liu X, Zhao P, Wang X, Wang L, Zhu Y, Gao W

Triptolide Induces Glioma Cell Autophagy and Apoptosis via Upregulating the ROS/JNK and Downregulating the Akt/mTOR Signaling Pathways.

Front Oncol.

9:387.

(IF 4.848)

677. Jia P, Wu N, Jia D, Sun Y

Downregulation of MALAT1 alleviates saturated fatty acid-induced myocardial inflammatory injury via the miR-26a/HMGB1/TLR4/NF-κB axis.

DIABET METAB SYND OB.

12:655-665.

(IF 2.842)

678. Jue Jiang, Juan Wang, Xin He, Wenqi Ma, Lei Sun, Qi Zhou, Miao Li, Shanshan Yu

High Expression of SPAG5 Sustains the Malignant Growth and Invasion of Breast Cancer Cells Through the Activation of Wnt/β-catenin Signalling

CLIN EXP PHARMACOL P .

doi: 10.1111/1440-1681.13082.

(IF 2.092)

679. Huang C, Wen C, Yang M, Gan D, Fan C, Li A, Li Q, Zhao J, Zhu L, Lu D

Lycopene protects against t-BHP-induced neuronal oxidative damage and apoptosis via activation of the PI3K/Akt pathway.

Mol Biol Rep.

46(3):3387-3397.

(IF 1.402)

680. Li YL, Rao MJ, Zhang NY, Wu LW, Lin NM, Zhang C

BAY 87-2243 sensitizes hepatocellular carcinoma Hep3B cells to histone deacetylase inhibitors treatment via GSK-3β activation.

Exp Ther Med.

17(6):4547-4553.

(IF 1.785)

681. Bai J, Yao B, Wang L, Sun L, Chen T, Liu R, Yin G, Xu Q, Yang W

lncRNA A1BG-AS1 suppresses proliferation and invasion of hepatocellular carcinoma cells by targeting miR-216a-5p.

J Cell Biochem.

120(6):10310-10322.

(IF 4.237)

682. Liu B, Lu Y, Wang Y, Ge L, Zhai N, Han J

A protocol for isolation and identification and comparative characterization of primary osteoblasts from mouse and rat calvaria.

Cell Tissue Bank.

20(2):173-182.

(IF 1.149)

683. Xu RY, Xu XW, Deng YZ, Ma ZX, Li XR, Zhao L, Qiu LJ, Liu HY, Chen HP

Resveratrol attenuates myocardial hypoxia/reoxygenation-induced cell apoptosis through DJ-1-mediated SIRT1-p53 pathway.

BIOCHEM BIOPH RES CO.

514(2):401-406.

(IF 2.985)

684. Jiang L, Zhu Z, Wen Y, Ye S, Su C, Zhang R, Shao W

Facile Construction of Functionalized GO Nanocomposites with Enhanced Antibacterial Activity.

Nanomaterials (Basel).

9(7). pii: E913.

685. Wang Y, Ai L, Hai B, Cao Y, Li R, Li H, Li Y

Tempol alleviates chronic intermittent hypoxia-induced pancreatic injury through repressing inflammation and apoptosis.

Physiol Res.

68(3):445-455.

(IF 1.655)

686. Yuan B, Wu W, Zhang H, Gu H, Guo D, Jiang J, Wang X

Adenomatous polyposis coli as a predictor of environmental chemical-induced transgenerational effects related to male infertility.

J BIOCHEM MOL TOXIC.

33(7):e22331.

(IF 3.606)

687. Wu Y, Zou F, Lu Y, Li X, Li F, Feng X, Sun X, Liu Y

SETD7 promotes TNF-α-induced proliferation and migration of airway smooth muscle cells in vitro through enhancing NF-κB/CD38 signaling.

Int Immunopharmacol.

72:459-466.

(IF 3.943)

688. Liu Y, Su H, Ma C, Ji D, Zheng X, Wang P, Zheng S, Wang L, Wang Z, Xu D

IQGAP1 mediates podocyte injury in diabetic kidney disease by regulating nephrin endocytosis.

Cell Signal.

59:13-23.

(IF 3.968)

689. Deng N, Lei D, Huang J, Yang Z, Fan C, Wang S

Circular RNA expression profiling identifies hsa_circ_0011460 as a novel molecule in severe preeclampsia.

Pregnancy Hypertens.

17:216-225.

(IF 2.095)

690. Chen M, Wang F, Cao JJ, Han X, Lu WW, Ji X, Chen WH, Lu WQ, Liu AL

(-)-Epigallocatechin-3-gallate attenuates the toxicity of methylmercury in Caenorhabditis elegans by activating SKN-1.

CHEM-BIOL INTERACT.

307:125-135.

(IF 3.723)

691. Zhang Y, Liu L, Sun D, He Y, Jiang Y, Cheng KW, Chen F

DHA protects against monosodium urate-induced inflammation through modulation of oxidative stress.

Food Funct.

10(7):4010-4021.

(IF 4.171)

692. Du ZD, Wei W, Yu S, Song QL, Liu K, Gong SS

NADPH Oxidase 2-Mediated Insult in the Auditory Cortex of Zucker Diabetic Fatty Rats.

Neural Plast.

2019:3591605.

(IF 3.093)

693. Zhou YT, Qiu JJ, Wang Y, Liu PC, Lv Q, Du ZG

Sperm Protein Antigen 17 Expression Correlates With Lymph Node Metastasis and Worse Overall Survival in Patients With Breast Cancer.

Front Oncol.

9:710.

(IF 4.848)

694. Wu Y, Zhuang J, Zhao D, Xu C

Interaction between caspase-3 and caspase-5 in the stretch-induced programmed cell death in the human periodontal ligament cells.

J Cell Physiol.

234(8):13571-13581.

(IF 5.546)

695. Li Z, Chen S, Chen S, Huang D, Ma K, Shao Z

Moderate activation of Wnt/β-catenin signaling promotes the survival of rat nucleus pulposus cells via regulating apoptosis, autophagy, and senescence.

J Cell Biochem.

120(8):12519-12533.

(IF 4.237)

696. Du J, Liu J, Zhen J, Yang ST, Zheng EL, Leng JY

Astragaloside IV protects cardiomyocytes from hypoxia-induced injury by down-regulation of lncRNA GAS5.

Biomed Pharmacother.

116:109028.

(IF 4.545)

697. Chen X, Han K, Lin G, Liu C, Wang S, Shi X, Hu Z, Wu C, Xu X, Hu C

Ctenopharyngodon Idella STAT3 alleviates autophagy by up-regulating BCL-2 expression.

FISH SHELLFISH IMMUN.

91:194-201.

(IF 3.298)

698. Hao P, Kang B, Li Y, Hao W, Ma F

UBE2T promotes proliferation and regulates PI3K/Akt signaling in renal cell carcinoma.

Mol Med Rep.

20(2):1212-1220.

(IF 2.1)

699. Xu Y, Yu L, Hao C, Wang Y, Zhu C, Ji W, Li Y, Li G, Chen Z, Yan Y

Plasma soluble B7-H3 levels for severity evaluation in pediatric patients with Mycoplasma pneumoniae pneumonia.

Int Immunopharmacol.

73:163-171.

(IF 3.943)

700. Wu B, Miao X, Ye J, Pu X

The Protective Effects of Protease Inhibitor MG-132 on Sepsis-Induced Acute Lung Rats and Its Possible Mechanisms.

MED SCI MONITOR.

25:5690-5699.

(IF 1.918)

701. Zhang Y, Liu Y, Bi X, Hu C, Ding F, Ding W

Therapeutic Approaches in Mitochondrial Dysfunction, Inflammation, and Autophagy in Uremic Cachexia: Role of Aerobic Exercise.

MEDIAT INFLAMM.

2019:2789014.

(IF 3.758)

702. Zhao G, Zhang L, Qian D, Sun Y, Liu W

miR-495-3p inhibits the cell proliferation, invasion and migration of osteosarcoma by targeting C1q/TNF-related protein 3.

ONCOTARGETS THER.

12:6133-6143.

(IF 3.337)

703. Fei D, Zhao H, Wang Y, Liu J, Mu M, Guo M, Yang X, Xing M.

The disturbance of autophagy and apoptosis in the gizzard caused by copper and/or arsenic are related to mitochondrial kinetics.

Chemosphere.

231:1-9.

(IF 5.778)

704. Song J, Ma SJ, Luo JH, Liu H, Li L, Zhang ZG, Chen LS, Zhou RX

Downregulation of AKT and MDM2, Melatonin Induces Apoptosis in AGS and MGC803 Cells.

ANAT REC.

302(9):1544-1551.

(IF 1.634)

705. Wang HL, Liu YC, Long MP, Zheng C, Yang JH

Blocking ROR1 enhances the roles of erlotinib in lung adenocarcinoma cell lines.

Oncol Lett.

18(3):2977-2984.

(IF 2.311)

706. Cao S, Li L, Geng X, Ma Y, Huang X, Kang X

The upregulation of miR-101 promotes vascular endothelial cell apoptosis and suppresses cell migration in acute coronary syndrome by targeting CDH5.

INT J CLIN EXP PATHO.

12(9):3320-3328. eCollection 2019.

(IF 0.252)

707. Xu B, Lang L, Li S, Yuan J, Wang J, Yang H, Lian S

Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure.

Animals (Basel).

9(9). pii: E682.

708. Tong G, Wang Y, Xu C, Xu Y, Ye X, Zhou L, Zhu G, Zhou Z, Huang J

Long non-coding RNA FOXD3-AS1 aggravates ischemia/reperfusion injury of cardiomyocytes through promoting autophagy.

Am J Transl Res.

11(9):5634-5644. eCollection 2019.

(IF 3.375)

709. Zheng XY, Yang SM, Zhang R, Wang SM, Li GB, Zhou SW

Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes.

DRUG DES DEV THER.

13:3171-3180.

(IF 3.216)

710. Yao Y, Ma Y, Zhong N, Pei J

The Inverted U-Curve Association of Fluoride and Osteoclast Formation in Mice.

Biol Trace Elem Res.

191(2):419-425.

(IF 2.639)

711. Zuo H, Wang S, Feng J, Liu X

BRD4 contributes to high-glucose-induced podocyte injury by modulating Keap1/Nrf2/ARE signaling.

Biochimie.

165:100-107.

(IF 3.413)

712. Yang X, Sun L, Wang L, Yao B, Mo H, Yang W

LncRNA SNHG7 accelerates the proliferation, migration and invasion of hepatocellular carcinoma cells via regulating miR-122-5p and RPL4.

Biomed Pharmacother.

118:109386.

(IF 4.545)

713. Peng J, Zhang L, Meng Q, Zhang F, Mao X, Liu J, Chen Y, Zou H, Shi B, Wu R, Huang B, Huang Y, Tan J, Feng C, Zhang X

Adverse impact of ambient PM2.5 on expression and trafficking of surfactant protein A through reactive oxygen species damage to lamellar bodies.

Toxicol Lett.

315:47-54.

(IF 3.569)

714. Li L, Hua L, Fan H, He Y, Xu W, Zhang L, Yang J, Deng F, Zeng F

Interplay of PKD3 with SREBP1 Promotes Cell Growth via Upregulating Lipogenesis in Prostate Cancer Cells.

J Cancer.

10(25):6395-6404.

(IF 3.565)

715. Yan L, Liu G, Cao H, Zhang H, Shao F

Hsa_circ_0035483 sponges hsa-miR-335 to promote the gemcitabine-resistance of human renal cancer cells by autophagy regulation.

BIOCHEM BIOPH RES CO.

519(1):172-178.

(IF 2.985)

716. Wang Y, Xu C, Xu B, Li L, Li W, Wang W, Wu M

Xiaoai Jiedu Recipe Inhibits Proliferation and Metastasis of Non-Small Cell Lung Cancer Cells by Blocking the P38 Mitogen-Activated Protein Kinase (MAPK) Pathway.

MED SCI MONITOR.

25:7538-7546.

(IF 1.918)

717. Ji G, Song X, Wang L, Li Z, Wu H, Dong H

Golgi apparatus fragmentation participates in oxidized low-density lipoprotein-induced endothelial cell injury.

J Cell Biochem.

120(11):18862-18870.

(IF 4.237)

718. Lu G, Xu L, Zhang P, Dou X, Yu J, Feng H

Betulin efficiently suppresses the process of an experimental Listeria monocytogenes infection as an antagonist against listeriolysin O.

Fitoterapia.

139:104409.

(IF 2.527)

719. Wei Y, Zhang Y, Meng Q, Cui L, Xu C

Hypoxia-induced circular RNA has_circRNA_403658 promotes bladder cancer cell growth through activation of LDHA.

Am J Transl Res.

11(11):6838-6849. eCollection 2019.

(IF 3.375)

720. Yin X, Zhang J, Li C, Zhang Z, Jin T, Song L, Zhang R, Wang W, Tao Y, Wang X

LncRNA HOXA11-AS accumulation-induced microRNA-761 downregulation regulates cell growth by targeting TRIM29 in papillary thyroid cancer.

Am J Transl Res.

11(11):6826-6837. eCollection 2019.

(IF 3.375)

721. Li LT, Wang X, Zhu WT, Qian GW, Pei DS, Zheng JN

Reciprocal Role Of DNA Methylation And Sp1 Binding In Ki-67 Gene Transcription.

Cancer Manag Res.

11:9749-9759.

(IF 2.886)

722. Chang B, Qiu H, Zhao H, Yang X, Wang Y, Ji T, Zhang Y, Quan Q, Li Y, Zeng J, Meng H, Gu Y

The Effects of Photobiomodulation on MC3T3-E1 Cells via 630 nm and 810 nm Light-Emitting Diode.

MED SCI MONITOR.

25:8744-8752.

(IF 1.918)

723. Li Y, Song Y, Wang Z, Zhang Z, Lu M, Wang Y

Long Non-coding RNA LINC01787 Drives Breast Cancer Progression via Disrupting miR-125b Generation.

Front Oncol.

9:1140.

(IF 4.848)

724. Li X, Han ZN, Liu Y, Hong L, Cui BR, Cui X

Endogenous ET-1 promotes ANP secretion through activation of COX2-L-PGDS-PPARγ signaling in hypoxic beating rat atria.

Peptides.

122:170150.

(IF 2.843)

725. Li X, Li X, Han B, Zhao Y, Li T, Zhao P, Yu X

Improvement in lipid production in Monoraphidium sp. QLY-1 by combining fulvic acid treatment and salinity stress.

BIORESOURCE TECHNOL.

294:122179.

(IF 7.539)

726. Wu N, Zhang X, Bao Y, Yu H, Jia D, Ma C

Down-regulation of GAS5 ameliorates myocardial ischaemia/reperfusion injury via the miR-335/ROCK1/AKT/GSK-3β axis.

J Cell Mol Med.

23(12):8420-8431.

(IF 4.486)

727. Yuan BY, Chen YH, Wu ZF, Zhuang Y, Chen GW, Zhang L, Zhang HG, Cheng JC, Lin Q, Zeng ZC

MicroRNA-146a-5p Attenuates Fibrosis-related Molecules in Irradiated and TGF-beta1-Treated Human Hepatic Stellate Cells by Regulating PTPRA-SRC Signaling.

Radiat Res.

192(6):621-629.

(IF 2.657)

728. Shi S, Zhang J, Liu M, Dong H, Li N

Ras-ERK signalling represses H1.4 phosphorylation at serine 36 to promote non-small-cell lung carcinoma cells growth and migration.

ARTIF CELL NANOMED B.

47(1):2343-2351.

(IF 3.343)

729. Zhou C, Liu Q, Zhao W, Yang L, Huang Z, Yang Z

Nrdp1 increases neuron apoptosis via downregulation of Bruce following intracerebral haemorrhage.

J INFLAMM-LOND.

16:24.

(IF 2.8)

730. Bin Xu, Li-Min Lang, Shuai Lian, Jing-Ru Guo, Jian-Fa Wang, Juxiong Liu, Huan-Min Yang, Shi-Ze Li

Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure

Brain Res.

doi: 10.1016/j.brainres.2019.146495.

(IF 2.733)

731. Guannan Zhang, Xingyu Zhang, Yongqiang Yang, Ruifang Chi, Jing Shi, Ruiqiang Hang, Xiaobo Huang, Xiaohong Yao, Paul K Chu, Xiangyu Zhang

Dual light-induced in situ antibacterial activities of biocompatibleTiO 2/MoS 2/PDA/RGD nanorod arrays on titanium

Biomater Sci.

doi: 10.1039/c9bm01507h.

732. Liqun Tang, Xiaoqin Yu, Yangyang Zheng, Ning Zhou

Inhibiting SLC26A4 reverses cardiac hypertrophy in H9C2 cells and in rats

PeerJ.

doi: 10.7717/peerj.8253.

(IF 2.379)

733. Fei Liu, Xinrong Tao, Gang Pang, Diqing Wu, Yuting Hu, Song Xue, Jing Liu, Bing Li, Li Zhou, Qiang Liu, Yong-Mei Zhang

Maternal Nicotine Exposure During Gestation and Lactation Period Affects Behavior and Hippocampal Neurogenesis in Mouse Offspring

Front Pharmacol.

doi: 10.3389/fphar.2019.01569.

(IF 4.225)

734. Mao-Xu Ge, Hong-Tao Liu, Na Zhang, Wei-Xiao Niu, Zhen-Ning Lu, Yun-Yang Bao, Rui Huang, Dong-Ke Yu, Rong-Guang Shao, Hong-Wei He

Costunolide represses hepatic fibrosis through WW domain-containing protein 2-mediated Notch3 degradation

Br J Pharmacol.

doi: 10.1111/bph.14873.

735. Wei Tian, Zhuo Wang, Nan-Nan Tang, Jia-Tong Li, Yu Liu, Wen-Feng Chu, Bao-Feng Yang

Ascorbic Acid Sensitizes Colorectal Carcinoma to the Cytotoxicity of Arsenic Trioxide via Promoting Reactive Oxygen Species-Dependent Apoptosis and Pyroptosis

Front Pharmacol.

doi: 10.3389/fphar.2020.00123.

(IF 4.225)

736. Xiong Zhang, Lan-Bing Zhu, Jia-Hui He, Hong-Qiu Zhang, Shu-Ya Ji, Chao-Nan Zhang, Na-Na Hou, Chen-Ping Huang, Jian-Hong Zhu

Paroxetine suppresses reactive microglia-mediated but not lipopolysaccharide-induced inflammatory responses in primary astrocytes

J Neuroinflammation.

doi: 10.1186/s12974-020-1712-0.

737. Xiaohua Pan, Jiahong Li, Xing Tu, Chengfei Wu, He Liu, Yang Luo, Xiaoliang Dong, Xiu Li, Li-Long Pan, Jia Sun

Lysine-specific demethylase-1 regulates fibroblast activation in pulmonary fibrosis via TGF-β1/Smad3 pathway

Pharmacol Res.

doi: 10.1016/j.phrs.2019.104592.

(IF 5.893)

738. Kai Kang, Jun-Bo Chuai, Bao-Dong Xie, Jian-Zhong Li, Hui Qu, Hua Wu, Shao-Hong Fang, Jin-Jin Cui, Li-Li Xiu, Jin-Cheng Han, Tian-Hui Cao, Xiao-Ping Leng, Hai Tian, Ren-Ke Li, Shu-Lin Jiang

Mesenchymal Stromal Cells from Patients with Cyanotic Congenital Heart Disease are Optimal Candidate for Cardiac Tissue Engineering

Biomaterials.

doi: 10.1016/j.biomaterials.2019.119574.

(IF 10.317)

739. Wang H, Luan H, Zhan T, Liu X, Song J, Dai H

Long non-coding RNA LINC00707 acts as a competing endogenous RNA to enhance cell proliferation in colorectal cancer.

Exp Ther Med.

19(2):1439-1447.

(IF 1.785)

740. Du ZD, Han SG, Qu TF, Guo B, Yu SK, Wei W, Feng S, Liu K, Gong SS

Age-related insult of cochlear ribbon synapses: An early-onset contributor to D-galactose-induced aging in mice.

Neurochem Int.

133:104649.

(IF 3.881)

741. Liu Y, Jiang Y, Li W, Han C, Zhou L, Hu H

MicroRNA-200c-3p inhibits proliferation and migration of renal artery endothelial cells by directly targeting ZEB2.

Exp Cell Res.

387(2):111778.

(IF 3.383)

742. Zhao Y, Su L, Li K, Zhao B.

Discovery of novel PC-PLC activity inhibitors.

Chem Biol Drug Des.

95(3):380-387.

(IF 2.548)

743. Qinghui Meng, Weihua Wu, Tiemin Pei, Junlin Xue, Peng Xiao, Liang Sun, Long Li, Desen Liang

miRNA-129/FBW7/NF-κB, a Novel Regulatory Pathway in Inflammatory Bowel Disease

MOL THER-NUCL ACIDS.

doi: 10.1016/j.omtn.2019.10.048.

(IF 7.032)

744. Xiuxiu Chen, Yiqin Tian, Haitao Zhu, Chen Bian, Min Li

Inhibition of steroid receptor coactivator-1 in the hippocampus impairs the consolidation and reconsolidation of contextual fear memory in mice

Life Sci.

doi: 10.1016/j.lfs.2020.117386.

(IF 3.647)

745. Yue Geng, Yeting Chen, Wei Sun, Yingmin Gu, Yongjie Zhang, Mei Li, Jiajun Xie, Xuesong Tian

Electroacupuncture Ameliorates Cerebral I/R-Induced Inflammation through DOR-BDNF/TrkB Pathway

Evid Based Complement Alternat Med.

doi: 10.1155/2020/3495836.

746. Huan Liu, Xiaobao Gong, Kai Yang

Overexpression of the clock gene Per2 suppresses oral squamous cell carcinoma progression by activating autophagy via the PI3K/AKT/mTOR pathway

J Cancer.

doi: 10.7150/jca.42771.

(IF 3.565)

747. Na Zhu, Jiang Li, Yongli Li, Yuwei Zhang, Qiubo Du, Peiyuan Hao, Jinying Li, Xueming Cao, Li Li

Berberine Protects Against Simulated Ischemia/Reperfusion Injury-Induced H9C2 Cardiomyocytes Apoptosis In Vitro and Myocardial Ischemia/Reperfusion-Induced Apoptosis In Vivo by Regulating the Mitophag

Front Pharmacol.

doi: 10.3389/fphar.2020.00367.

(IF 4.225)

748. Hui Wang, Xuefei Li, Hui Yang, Jun Wang, Qiqi Li, Ruijing Qu, Xianggen Wu

Nanocomplexes based polyvinylpyrrolidone K-17PF for ocular drug delivery of naringenin

Int J Pharm.

doi: 10.1016/j.ijpharm.2020.119133.

749. Gui Wu, Fei Huang, Yaoqing Chen, Yuehong Zhuang, Yunpeng Huang, Yun Xie

High Levels of BMP2 Promote Liver Cancer Growth via the Activation of Myeloid-Derived Suppressor Cells

Front Oncol.

doi: 10.3389/fonc.2020.00194.

(IF 4.848)

750. Yong He, Zhonghao Wu, Tianlan Lan, Yue Wang, Yu Tian, Xi Chen, Yan Li, Mengge Bai, Jie Liu, Xue Gong, Ke Cheng, Peng Xie

The 25(OH)D/VDR signaling may play a role in major depression

Biochem Biophys Res Commun.

doi: 10.1016/j.bbrc.2019.12.071.

751. Weiwei Li, Jiancheng Yang, Qiufeng Lyu, Gaofeng Wu, Shumei Lin, Qunhui Yang, Jianmin Hu

Taurine prevents cardiomyocyte apoptosis by inhibiting the calpain-1/cytochrome c pathway during RVH in broilers

Amino Acids.

doi: 10.1007/s00726-020-02824-5.

(IF 3.063)

752. Zhen Dong, Jie Yang, Lin Li, Li Tan, Pengfei Shi, Jiayi Zhang, Xi Zhong, Lingjun Ge, Zonghui Wu, Hongjuan Cui

FOXO3a‑SIRT6 axis suppresses aerobic glycolysis in melanoma

Int J Oncol.

doi: 10.3892/ijo.2020.4964.

(IF 3.899)

753. Lincheng Ju, Liping Shan, Bo Yin, Yongsheng Song

δ-Catenin regulates proliferation and apoptosis in renal cell carcinoma via promoting β-catenin nuclear localization and activating its downstream target genes

Cancer Med.

doi: 10.1002/cam4.2857.

754. Wang Y, Li Y, Shao P, Wang L, Bao X, Hu M

IL1β inhibits differentiation of cementoblasts via microRNA-325-3p.

J Cell Biochem.

121(3):2606-2617.

(IF 4.237)

755. Yin Du, Xiaozhen Ma, Lei Ma, Siyuan Li, Juan Zheng, Junlin Lv, Long Cui, Jianrui Lv

Inhibition of microRNA-148b-3p Alleviates Oxygen-Glucose Deprivation/Reoxygenation-Induced Apoptosis and Oxidative Stress in HT22 Hippocampal Neuron via Reinforcing Sestrin2/Nrf2 Signalling

CLIN EXP PHARMACOL P .

doi: 10.1111/1440-1681.13231.

(IF 2.092)

756. Xin Yi Chu, Shi Zhen Yang, Meng Qing Zhu, Dan Yang Zhang, Xiao Chen Shi, Bo Xia, Ye Yuan, Min Liu, Jiang Wei Wu

Isorhapontigenin Improves Diabetes in Mice via Regulating the Activity and Stability of PPARγ in Adipocytes

J Agric Food Chem.

doi: 10.1021/acs.jafc.0c00515.

757. Yang X, Zhang C, Tie H, Luo J, Wang Y, Wu Q

miR-760 exerts an antioncogenic effect in esophageal squamous cell carcinoma by negatively driving fat metabolism via targeting c-Myc.

J Cell Biochem.

121(4):2950-2961.

(IF 4.237)

758. Lu H, Sun L, Chen W, Zhou Y, Liu K, Chen J, Zhang Z, Zhang C, Tian H

Sirtuin 3 Therapy Attenuates Aging Expression, Oxidative Stress Parameters, and Neointimal Hyperplasia Formation in Vein Grafts.

Ann Vasc Surg.

64:303-317.

(IF 1.125)

759. Yifan Wu, Yang Jin, Tianyu Sun, Piaoyu Zhu, Jinlong Li, Qinglin Zhang, Xiaoke Wang, Junkang Jiang, Gang Chen, Xinyuan Zhao

p62/SQSTM1 accumulation due to degradation inhibition and transcriptional activation plays a critical role in silica nanoparticle-induced airway inflammation via NF-κB activation

J Nanobiotechnology.

doi: 10.1186/s12951-020-00634-1.

760. Hao Zhang, Yanan Chen, Yueping Chen, Peilu Jia, Shuli Ji, Jianxiong Xu, Yue Li, Tian Wang

Comparison of the effects of resveratrol and its derivative pterostilbene on hepatic oxidative stress and mitochondrial dysfunction in piglets challenged with diquat

Food Funct.

doi: 10.1039/d0fo00732c.

(IF 4.171)

761. Jiannan Li, Zhan Zhang, Jiangbo Wang, Shuang Du, Dengbing Yao, Rangjuan Cao, Shusen Cui

Protein Kinase Cα Promotes Proliferation and Migration of Schwann Cells by Activating ERK Signaling Pathway

Neuroscience.

doi: 10.1016/j.neuroscience.2020.03.007.

(IF 3.056)

762. Xiangyuan Chen, Jie Qi, Qichao Wu, Hui Jiang, Jing Wang, Wankun Chen, Anrong Mao, Minmin Zhu

High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression

Acta Biochim Biophys Sin (Shanghai).

doi: 10.1093/abbs/gmaa023.

763. Ruonan Zhang, Ting Pan, Yu Xiang, Mingming Zhang, Jiao Feng, Shuiping Liu, Ting Duan, Peng Chen, Bingtao Zhai, Xiaying Chen, Wengang Wang, Bi Chen, Xuemeng Han, Liuxi Chen, Lili Yan, Ting Jin, Ying Liu, Guohua Li, Xingxing Huang, Wenzheng Zhang, Yitian Sun, Qiujie Li, Qin Zhang, Lvjia Zhuo, Tian Xie, Qibiao Wu, Xinbing Sui

β-Elemene Reverses the Resistance of p53-Deficient Colorectal Cancer Cells to 5-Fluorouracil by Inducing Pro-death Autophagy and Cyclin D3-Dependent Cycle Arrest

Front Bioeng Biotechnol.

doi: 10.3389/fbioe.2020.00378.

764. Yun Shen, Yongchu Pan, Shuyu Guo, Lian Sun, Chi Zhang, Lin Wang

The roles of mechanosensitive ion channels and associated downstream MAPK signaling pathways in PDLC mechanotransduction

Mol Med Rep.

doi: 10.3892/mmr.2020.11006.

(IF 2.1)

765. Bi Lin, Ziyuan Jin, Xiang Chen, Li Zhao, Chengwei Weng, Baihui Chen, Yaning Tang, Lina Lin

Necrostatin‑1 protects mice from acute lung injury by suppressing necroptosis and reactive oxygen species

Mol Med Rep.

doi: 10.3892/mmr.2020.11010.

(IF 2.1)

766. Chunyan Wang, Jingwei Cao, Shurong Duan, Ran Xu, Hongli Yu, Xin Huo, Yuanyuan Qian

Effect of MicroRNA-126a-3p on Bone Marrow Mesenchymal Stem Cells Repairing Blood-brain Barrier and Nerve Injury after Intracerebral Hemorrhage

J Stroke Cerebrovasc Dis.

doi: 10.1016/j.jstrokecerebrovasdis.2020.104748.

767. Zheng-Liang Shi, Hua Zhang, Zhi-Yong Fan, Wei Ma, Yong-Zhou Song, Ming Li, Tong-Qiu Li, Shu-Xing Cao, Guo-Jun Feng

Long noncoding RNA LINC00314 facilitates osteogenic differentiation of adipose-derived stem cells through the hsa-miR-129-5p/GRM5 axis via the Wnt signaling pathway

Stem Cell Res Ther.

doi: 10.1186/s13287-020-01754-z.

(IF 5.116)

768. Hao Zhang, Yanan Chen, Yueping Chen, Shuli Ji, Peilu Jia, Yue Li, Tian Wang

Comparison of the protective effects of resveratrol and pterostilbene against intestinal damage and redox imbalance in weanling piglets

J Anim Sci Biotechnol.

doi: 10.1186/s40104-020-00460-3.

769. Yifan Ren, Jia Zhang, Mengzhou Wang, Jianbin Bi, Tao Wang, Minglong Qiu, Yi Lv, Zheng Wu, Rongqian Wu

Identification of irisin as a therapeutic agent that inhibits oxidative stress and fibrosis in a murine model of chronic pancreatitis

Biomed Pharmacother.

doi: 10.1016/j.biopha.2020.110101.

(IF 4.545)

770. Xiaohan Chang, Huijie Zhang, Qing Yang, Li Pang

LncRNA SOX2OT affects cervical cancer cell growth, migration and invasion by regulating SOX2

Cell Cycle.

doi: 10.1080/15384101.2020.1750812.

(IF 3.699)

771. Li Lv, Wenhui Zhang, Tingting Li, Lifeng Jiang, Xinyan Lu, Jie Lin

Hispidulin exhibits potent anticancer activity in vitro and in vivo through activating ER stress in non‑small‑cell lung cancer cells

Oncol Rep.

doi: 10.3892/or.2020.7568.

(IF 3.417)

772. Jun-Xiao Yang, Peng Xie, Yu-Sheng Li, Ting Wen, Xu-Cheng Yang

Osteoclast-derived miR-23a-5p-containing exosomes inhibit osteogenic differentiation by regulating Runx2

Cell Signal.

doi: 10.1016/j.cellsig.2019.109504.

(IF 3.968)

773. Jili Fu, Kija Malale Nchambi, Hao Wu, Xie Luo, Xizhou An, Dongfang Liu

Liraglutide protects pancreatic β cells from endoplasmic reticulum stress by upregulating MANF to promote autophagy turnover

Life Sci.

doi: 10.1016/j.lfs.2020.117648.

(IF 3.647)

774. Yujing Zhang, Huanfeng Bian, Yu Ma, Yuanyuan Xiao, Fang Xiao

Cr(VI)-induced overactive mitophagy contributes to mitochondrial loss and cytotoxicity in L02 hepatocytes

Biochem J.

doi: 10.1042/BCJ20200262.

(IF 4.097)

775. Shuang Chen, Mengzhen Li, Wei Jiang, Hao Zheng, Lian-Wen Qi, Shujun Jiang

The role of Neu1 in the protective effect of dipsacoside B on acetaminophen-induced liver injury

Ann Transl Med.

doi: 10.21037/atm-19-3850.

(IF 3.297)

776. Dong-Shan Zhu, Jing-Yao Dong, Yao-Yao Xu, Xin-Tong Zhang, Shi-Bo Fu, Wei Liu

Omipalisib Inhibits Esophageal Squamous Cell Carcinoma Growth Through Inactivation of Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) and ERK Signaling

Med Sci Monit.

doi: 10.12659/MSM.927106.

777. Tianqing Yan, Chang Liang, Haidi Fan, Wei Zhou, Linyan Huang, Suhua Qi, Wan Wang, Ping Ma

KAP1 silencing relieves OxLDL-induced vascular endothelial dysfunction by down-regulating LOX-1

Biosci Rep.

doi: 10.1042/BSR20200821.

778. Fudong Zhu, Xiaobo Cai, Xin Yang, Jianfeng He, Chengze Wang, Mingxiang Wang, Aili Simaiti, Wei Yang, Xinqiang Zhu, Peilin Yu

TRPM2 expression levels are associated with histological grading in patients with tongue squamous cell carcinoma

Mol Med Rep.

doi: 10.3892/mmr.2020.11417.

(IF 2.1)

779. Jingle Jiang, Siyi Liu, Tuniyaz Jamal, Tengxin Ding, Lina Qi, Zengpeng Lv, Debing Yu, Fangxiong Shi

Effects of dietary sweeteners supplementation on growth performance, serum biochemicals, and jejunal physiological functions of broiler chickens

Poult Sci.

doi: 10.1016/j.psj.2020.03.057.

780. Lili Chen, Shue Li, Jiaming Nie, Jiajia Zhao, Shaoling Yu, Yaoxu Li, Jinfeng Peng

Bmal1 Regulates Coagulation Factor Biosynthesis in Mouse Liver in Streptococcus oralis Infection

Front Cell Infect Microbiol.

doi: 10.3389/fcimb.2020.530190.

781. Linan Guan, Chao Li, Yi Zhang, Jianying Gong, Guangyu Wang, Pei Tian, Ning Shen

Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome

Life Sci.

doi: 10.1016/j.lfs.2020.117935.

(IF 3.647)

782. Lingling Li, Dan Luo, Yating Liao, Kailan Peng, Yanhua Zeng

Mycoplasma genitalium Protein of Adhesion Induces Inflammatory Cytokines via Cyclophilin A-CD147 Activating the ERK-NF-κB Pathway in Human Urothelial Cells

Front Immunol.

doi: 10.3389/fimmu.2020.02052.

(IF 5.085)

783. Hui Wang, Feng Yang, Ruihua Xin, Dongan Cui, Jiongjie He, Shidong Zhang, Yan Sun

The gut microbiota attenuate neuroinflammation in manganese exposure by inhibiting cerebral NLRP3 inflammasome

Biomed Pharmacother.

doi: 10.1016/j.biopha.2020.110449.

(IF 4.545)

784. Kun Ma, Chuan Zhang, Wuyin Li

TGF-β is associated with poor prognosis and promotes osteosarcoma progression via PI3K/Akt pathway activation

Cell Cycle.

doi: 10.1080/15384101.2020.1805552.

(IF 3.699)

785. Li Mao, Mei-Ling Zuo, Ai-Ping Wang, Ying Tian, Li-Chen Dong, Tao-Ming Li, Da-Bin Kuang, Gui-Lin Song, Zhong-Bao Yang

Low expression of miR‑532‑3p contributes to cerebral ischemia/reperfusion oxidative stress injury by directly targeting NOX2

Mol Med Rep.

doi: 10.3892/mmr.2020.11325.

(IF 2.1)

786. Shuyu Liu, Renjun Yang, Nuoya Yin, Francesco Faiola

Effects of per- and poly-fluorinated alkyl substances on pancreatic and endocrine differentiation of human pluripotent stem cells

Chemosphere.

doi: 10.1016/j.chemosphere.2020.126709.

(IF 5.778)

787. Shengyang Jin, Chunqing Meng, Yu He, Xiaohong Wang, Qimin Zhang, Ze Wang, Wei Huang, Hong Wang

Curcumin prevents osteocyte apoptosis by inhibiting M1-type macrophage polarization in mice model of glucocorticoid-associated osteonecrosis of the femoral head

J Orthop Res.

doi: 10.1002/jor.24619.

(IF 2.728)

788. Bei-Bei Deng, Bao-Ping Jiao, Yang-Jun Liu, Yan-Rong Li, Gui-Jun Wang

BIX-01294 enhanced chemotherapy effect in gastric cancer by inducing GSDME-mediated pyroptosis

Cell Biol Int.

doi: 10.1002/cbin.11395.

(IF 2.571)

789. Ya Gao, Boting Xi, Jiani Li, Zimeng Li, Jie Xu, Mingli Zhong, Qiongmei Xu, Yuanyu Lian, Riming Wei, Liping Wang, Houkang Cao, Ling Jin, Kefeng Zhang, Jianghui Dong

Scoparone alleviates hepatic fibrosis by inhibiting the TLR-4/NF-κB pathway

J Cell Physiol.

doi: 10.1002/jcp.30083.

(IF 5.546)

790. Chao Li, Sheng Zhang, Liming Li, Qing Hu, Shen Ji

Ursodeoxycholic Acid Protects Against Arsenic Induced Hepatotoxicity by the Nrf2 Signaling Pathway

Front Pharmacol.

doi: 10.3389/fphar.2020.594496.

(IF 4.225)

791. Dianbao Zhang, Chunhe Li, Luting Zhang, Bo Li, Yu Wang, Rui Wang, Zaixing Chen, Liang Xu, Tao Liu

Cannabisin D from Sinomenium Acutum Inhibits Proliferation and Migration of Glioblastoma Cells through MAPKs Signaling

Nutr Cancer.

doi: 10.1080/01635581.2020.1836240.

(IF 2.363)

792. Lei Wang

ELF1-activated FOXD3-AS1 promotes the migration, invasion and EMT of osteosarcoma cells via sponging miR-296-5p to upregulate ZCCHC3

J Bone Oncol.

doi: 10.1016/j.jbo.2020.100335.

(IF 3.066)

793. Liu-Jun He, Dong-Lin Yang, He-Ying Chen, Jiu-Hong Huang, Ya-Jun Zhang, Hong-Xia Qin, Juan-Li Wang, Dian-Yong Tang, Zhong-Zhu Chen

A Novel Imidazopyridine Derivative Exhibits Anticancer Activity in Breast Cancer by Inhibiting Wnt/β‑catenin Signaling

Onco Targets Ther.

doi: 10.2147/OTT.S266752.

794. Lan Jiang, Yanguo Zhang, Tao Liu, Xiaoxia Wang, Huan Wang, Haifeng Song, Wenting Wang

Exosomes derived from TSG-6 modified mesenchymal stromal cells attenuate scar formation during wound healing

Biochimie.

doi: 10.1016/j.biochi.2020.08.003.

(IF 3.413)

795. Jingyi Li, Tingting Wang, Chong Li, Zhifang Wang, Peng Wang, Lili Zheng

Sema3A and HIF1α co-overexpressed iPSC-MSCs/HA scaffold facilitates the repair of calvarial defect in a mouse model

J Cell Physiol.

doi: 10.1002/jcp.29569.

(IF 5.546)

796. Shunzhong Hong, Wenjie Cai, Zicheng Huang, Yubin Wang, Xifeng Mi, Yisen Huang, Zhijin Lin, Xiangbo Chen

Ginsenoside Rg3 enhances the anticancer effect of 5‑FU in colon cancer cells via the PI3K/AKT pathway

Oncol Rep.

doi: 10.3892/or.2020.7728.

(IF 3.417)

797. Yu Fan, Tu-Run Song, Qiang Wei, Lu Yang, Tao Lin, Xiao-Bing Feng, Xian-Ding Wang, Zhong-Li Huang, Shi-Jian Feng

Modulatory effect of aquaporin 5 on estrogen-induced epithelial-mesenchymal transition in prostate epithelial cells

Chin Med J (Engl).

doi: 10.1097/CM9.0000000000001132.

798. Shi Chen, Shiyi Tan, Shang Yang, Gang Chen, Li Zhu, Zhiqian Sun, Haibin Li, Sanqiao Yao

Nicotine induces apoptosis through exacerbation of blocked alveolar macrophage autophagic degradation in silicosis

Toxicol Lett.

doi: 10.1016/j.toxlet.2020.09.019.

(IF 3.569)

799. Ge Hong, Hao Wu, Shi-Tang Ma, Zhe Su

Catechins from oolong tea improve uterine defects by inhibiting STAT3 signaling in polycystic ovary syndrome mice

Chin Med.

doi: 10.1186/s13020-020-00405-y.

800. Linfeng Sun, Xiaoding Lin, Sakorn Pornprasert, Xiaomei Lü, Bing Ran, Yan Lin

L-type calcium channel blockers decrease the iron overload-mediated oxidative stress in renal epithelial cells by reducing iron accumulation

Eur J Pharmacol.

doi: 10.1016/j.ejphar.2020.173513.

(IF 3.263)

801. Jiajia Zhai, Zeping Li, Huifeng Zhang, Louyan Ma, Zhengquan Ma, Yi Zhang, Jian Zou, Mo Li, Li Ma, Xin Wang, Xiaomiao Li

Berberine protects against diabetic retinopathy by inhibiting cell apoptosis via deactivation of the NF‑κB signaling pathway

Mol Med Rep.

doi: 10.3892/mmr.2020.11505.

(IF 2.1)

802. Li-Ping Nan, Feng Wang, Di Ran, Shi-Feng Zhou, Yang Liu, Zhen Zhang, Ze-Nan Huang, Ze-Yu Wang, Jing-Cheng Wang, Xin-Min Feng, Liang Zhang

Naringin alleviates H 2 O 2-induced apoptosis via the PI3K/Akt pathway in rat nucleus pulposus-derived mesenchymal stem cells

Connect Tissue Res.

doi: 10.1080/03008207.2019.1631299.

(IF 2.795)

803. Joy Yue Zhang, Peihuang Wu, Danyang Chen, Fen Ning, Qinsheng Lu, Xiu Qiu, Martin Hewison, Jennifer A Tamblyn, Mark D Kilby, Gendie E Lash

Vitamin D Promotes Trophoblast Cell Induced Separation of Vascular Smooth Muscle Cells in Vascular Remodeling via Induction of G-CSF

Front Cell Dev Biol.

doi: 10.3389/fcell.2020.601043.

(IF 5.201)

804. Lili Wang, Jingzhen Zhou, Yong Zhang, Tao Hu, Yongning Sun

Long Non-Coding RNA HCG11 Aggravates Osteosarcoma Carcinogenesis via Regulating the microRNA-579/MMP13 Axis

Int J Gen Med.

doi: 10.2147/IJGM.S274641.

805. Shengjun Ji, Haohao Wu, Xin Ding, Qingqing Chen, Xing Jin, Jinming Yu, Ming Yang

Increased hippocampal TrkA expression ameliorates cranial radiation‑induced neurogenesis impairment and cognitive deficit via PI3K/AKT signaling

Oncol Rep.

doi: 10.3892/or.2020.7782.

(IF 3.417)

806. Tingting Huang, Xiaoxiao Luo, Bili Wu, Ping Peng, Yuhong Dai, Guangyuan Hu, Hong Qiu, Xianglin Yuan

Pyrotinib enhances the radiosensitivity of HER2‑overexpressing gastric and breast cancer cells

Oncol Rep.

doi: 10.3892/or.2020.7820.

(IF 3.417)

807. Ye Zhi, Chunhua Lu, Ganlin Zhu, Zhijie Li, Piaoyu Zhu, Yuting Liu, Weiwei Shi, Liling Su, Junkang Jiang, Jianhua Qu, Xinyuan Zhao

Positive regulation of the CREB phosphorylation via JNK-dependent pathway prevents antimony-induced neuronal apoptosis in PC12 cell and mice brain

Neurotoxicology.

doi: 10.1016/j.neuro.2020.09.002.

(IF 3.105)

808. Hao Zha, Wei Miao, Wei Rong, Aimei Wang, Weiqi Jiang, Rui Liu, Lanqi Liu, Ying Wang

Remote ischaemic perconditioning reduces the infarct volume and improves the neurological function of acute ischaemic stroke partially through the miR-153-5p/TLR4/p65/IkBa signalling pathway

Folia Neuropathol.

doi: 10.5114/fn.2021.112127.

(IF 1.278)

809. Lixia Sun, Renzhe Cui, Huan Meng, Xiwen Liu, Xin Liu, Yan Lu, Kun Liu, Liang Jia, Yajuan Zheng

Gene Suppression of the Chloride Channel 2 Suppressed TGF-β1-Induced Proliferation, Collagen Synthesis, and Collagen Gel Contraction Mediated by Conjunctival Fibroblasts

Ophthalmic Res.

doi: 10.1159/000507632.

(IF 1.961)

810. Hongyan Xu, Jing Shao, Jiachen Fang, Baozhen Yin, Luomeng Zhang, Jiasu Zhang, Guangjun Xia

miR-381 Targets KCTD15 to Regulate Bovine Preadipocyte Differentiation In Vitro

Horm Metab Res.

doi: 10.1055/a-1276-1602.

(IF 2.562)

811. Yi Liu, Yong Zhang, Meng Zhang, Jialin Meng, Qingqing Ma, Zongyao Hao, Meijuan Zheng, Li Zhang, Xianguo Chen, Chaozhao Liang

Activated autophagy restored the impaired frequency and function of regulatory T cells in chronic prostatitis

Prostate.

doi: 10.1002/pros.24073.

(IF 3.279)

812. Yingying Wang, Yingshuang Song, Qi Zhong, Yaqin Wu, Jiabao Zhuang, Fang Qu, Chun Xu

Suppressing ROS generation by apocynin inhibited cyclic stretch-induced inflammatory reaction in HPDLCs via a caspase-1 dependent pathway

Int Immunopharmacol.

doi: 10.1016/j.intimp.2020.107129.

(IF 3.943)

813. Jiao Meng, Ting Ding, Yuhua Chen, Tianlin Long, Quanhua Xu, Wenqing Lian, Wei Liu

LncRNA-Meg3 promotes Nlrp3-mediated microglial inflammation by targeting miR-7a-5p

Int Immunopharmacol.

doi: 10.1016/j.intimp.2020.107141.

(IF 3.943)

814. Zhaofu Liao, Yilin Chen, Chuncui Duan, Kuikui Zhu, Ruijin Huang, Hui Zhao, Maik Hintze, Qin Pu, Ziqiang Yuan, Luocheng Lv, Hongyi Chen, Binglin Lai, Shanshan Feng, Xufeng Qi, Dongqing Cai

Cardiac telocytes inhibit cardiac microvascular endothelial cell apoptosis through exosomal miRNA-21-5p-targeted cdip1 silencing to improve angiogenesis following myocardial infarction

Theranostics.

doi: 10.7150/thno.47021.

(IF 8.579)

815. Xiaomin Sun, Cuilian Ye, Qin Deng, Jingyu Chen, Chunbao Guo

Contribution of glutaredoxin-1 to Fas s-glutathionylation and inflammation in ethanol-induced liver injury

Life Sci.

doi: 10.1016/j.lfs.2020.118678.

(IF 3.647)

816. Hui Li, Linlin Liu, Zhiwen Cao, Wen Li, Rui Liu, Youwen Chen, Chenxi Li, Yurong Song, Guangzhi Liu, Jinghong Hu, Zhenli Liu, Cheng Lu, Yuanyan Liu

Naringenin ameliorates homocysteine induced endothelial damage via the AMPKα/Sirt1 pathway

J Adv Res.

doi: 10.1016/j.jare.2021.01.009.

(IF 6.992)

817. Guiqin Shi, Jiaxin Shen, Fei Ren, Weikai Yang

Molecular cloning, expression, and characterization of BmSOD3 in silkworm (Bombyx mori)

Arch Insect Biochem Physiol.

doi: 10.1002/arch.21744.

818. Litao Yan, Gejun Liu, Xing Wu

The umbilical cord mesenchymal stem cell-derived exosomal lncRNA H19 improves osteochondral activity through miR-29b-3p/FoxO3 axis

Clin Transl Med.

doi: 10.1002/ctm2.255.

819. Xianxian Jia, Bo Wu, Jinhui Huang, Lin Fan, Miao Yang, Wei Xu

YAP and Wnt3a independently promote AECIIs proliferation and differentiation by increasing nuclear β‑catenin expression in experimental bronchopulmonary dysplasia

Int J Mol Med.

doi: 10.3892/ijmm.2020.4791.

(IF 3.098)

820. Heng Chen, Guoliang Sa, Lin Li, Sangang He, Tianfu Wu

In vitro and in vivo synergistic anti-tumor effect of LIN28 inhibitor and metformin in oral squamous cell carcinoma

Eur J Pharmacol.

doi: 10.1016/j.ejphar.2020.173757.

(IF 3.263)

821. Yufei Luo, Bojun Xiong, Haiping Liu, Zehong Chen, Huihui Huang, Changxi Yu, Jian Yang

Koumine Suppresses IL-1β Secretion and Attenuates Inflammation Associated With Blocking ROS/NF-κB/NLRP3 Axis in Macrophages

Front Pharmacol.

doi: 10.3389/fphar.2020.622074.

(IF 4.225)

822. Shaofang Zhang, Ying Liu, Si Sun, Junying Wang, Qifeng Li, Ruijuan Yan, Yalong Gao, Haile Liu, Shuangjie Liu, Wenting Hao, Haitao Dai, Changlong Liu, Yuanming Sun, Wei Long, Xiaoyu Mu, Xiao-Dong Zhang

Catalytic patch with redox Cr/CeO 2 nanozyme of noninvasive intervention for brain trauma

Theranostics.

doi: 10.7150/thno.51912.

(IF 8.579)

823. Jiangfeng Liao, Guirong Zeng, Wenting Fang, Weibin Huang, Xiaoman Dai, Qinyong Ye, Jing Zhang, Xiaochun Chen

Increased Notch2/NF-κB Signaling May Mediate the Depression Susceptibility: Evidence from Chronic Social Defeat Stress Mice and WKY Rats

Physiol Behav.

doi: 10.1016/j.physbeh.2020.113197.

(IF 2.826)

824. Tao Zhang, Yu Dan Zheng, Man Jiao, Ye Zhi, Shen Ya Xu, Piao Yu Zhu, Xin Yuan Zhao, Qi Yun Wu

Nuclear Factor-κB Signaling Mediates Antimony-induced Astrocyte Activation

Biomed Environ Sci.

doi: 10.3967/bes2021.005.

(IF 2.656)

825. Zonghao Tang, Renfeng Xu, Zhenghong Zhang, Congjian Shi, Yan Zhang, Hongqin Yang, Qingqiang Lin, Yiping Liu, Fengping Lin, Baorong Geng, Zhengchao Wang

HIF-1α Protects Granulosa Cells From Hypoxia-Induced Apoptosis During Follicular Development by Inducing Autophagy

Front Cell Dev Biol.

doi: 10.3389/fcell.2021.631016.

(IF 5.201)

826. Huihui Xu, Song Dun, Ying Gao, Jian Ming, Linping Hui, Xueshan Qiu

TMEM107 inhibits EMT and invasion of NSCLC through regulating the Hedgehog pathway

Thorac Cancer.

doi: 10.1111/1759-7714.13715.

(IF 2.61)

827. Yuying Wang, Lulu Sun, Guihong Yu, Xin Qi, Aotong Zhang, Zhimin Lu, Dehai Li, Jing Li

Identification of a novel non-ATP-competitive protein kinase inhibitor of PGK1 from marine nature products

Biochem Pharmacol.

doi: 10.1016/j.bcp.2020.114343.

(IF 4.96)

828. Ling Li, Yu Bai, Runyu Du, Lei Tang, Ling Li

The role of Smad4 in the regulation of insulin resistance, inflammation and cell proliferation in HTR8-Svneo cells

Cell Biochem Funct.

doi: 10.1002/cbf.3594.

(IF 2.632)

829. Jie Wu, Lulu Sun, Tingting Liu, Gang Dong

Ultrasound-Targeted Microbubble Destruction-Mediated Downregulation of EZH2 Inhibits Stemness and Epithelial-Mesenchymal Transition of Liver Cancer Stem Cells

Onco Targets Ther.

doi: 10.2147/OTT.S269589.

830. Ya Xing, Cheng Xu, Xiao Lin, Minmeng Zhao, Daoqing Gong, Long Liu, Tuoyu Geng

Complement C3 participates in the development of goose fatty liver potentially by regulating the expression of FASN and ETNK1

Anim Sci J.

doi: 10.1111/asj.13527.

(IF 1.399)

831. Ye Yuan, Gege Yan, Mingyu He, Hong Lei, Linqiang Li, Yang Wang, Xiaoqi He, Guanghui Li, Quan Wang, Yuelin Gao, Zhezhe Qu, Zhongting Mei, Zhihua Shen, Jiaying Pu, Ao Wang, Wei Zhao, Huiwei Jiang, Weijie Du, Lei Yang

ALKBH5 suppresses tumor progression via an m6A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma

Cell Death Dis.

doi: 10.1038/s41419-020-03315-x.

(IF 6.304)

832. Yage Liang, Meijia Li, Zhaoqun Liu, Yuanmei Li, Lingling Wang, Linsheng Song

The glutaminase (CgGLS-1) mediates anti-bacterial immunity by prompting cytokine synthesis and hemocyte apoptosis in Pacific oyster Crassostrea gigas

Sci Rep.

doi: 10.1038/s41598-020-80552-2.

833. Zhiling Lou, Weijia Wu, Ruiheng Chen, Jie Xia, Haochun Shi, Hanwei Ge, Jiyang Xue, Hanlei Wang, Zhiyong Lin, Maoping Chu, Qifeng Zhao

Microarray analysis reveals a potential role of lncRNA expression in remote ischemic preconditioning in myocardial ischemia-reperfusion injury

Am J Transl Res.

(IF 3.375)

834. Jing Fang, Heng Yin, Zhuangzhi Yang, Maoyun Tan, Fengyuan Wang, Kejie Chen, Zhicai Zuo, Gang Shu, Hengmin Cui, Ping Ouyang, Hongrui Guo, Zhengli Chen, Chao Huang, Yi Geng, Wentao Liu

Vitamin E protects against cadmium-induced sub-chronic liver injury associated with the inhibition of oxidative stress and activation of Nrf2 pathway

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2020.111610.

835. Qiuyuan Lu, Feifei Ren, Jiming Yan, Yinong Zhang, Mian Awais, Jian He, Jingchen Sun

Alkaline phosphatase can promote the replication of Bombyx mori cypovirus 1 by interaction with its turret protein

Virus Res.

doi: 10.1016/j.virusres.2020.198261.

(IF 2.934)

836. Qi Li, Xiaoxia Liu, Weifang Liu, Yang Zhang, Mengying Wu, Zhirui Chen, Yin Zhao, Li Zou

MALAT1 sponges miR-26a and miR-26b to regulate endothelial cell angiogenesis via PFKFB3-driven glycolysis in early-onset preeclampsia

Mol Ther Nucleic Acids.

doi: 10.1016/j.omtn.2021.01.005.

837. Lun Zhang, Shuiqing Gui, Yinghua Xu, Jiali Zeng, Jian Wang, Qingru Chen, Liqian Su, Ziyan Wang, Rui Deng, Fujiang Chu, Wenbin Liu, Xiaobao Jin, Xuemei Lu

Colon tissue-accumulating mesoporous carbon nanoparticles loaded with Musca domestica cecropin for ulcerative colitis therapy

Theranostics.

doi: 10.7150/thno.53105.

(IF 8.579)

838. Yuqian Guo, Guoxing Li, Lei Gao, Xiaocheng Cheng, Liyou Wang, Yuhong Qin, Dongying Zhang

Exaggerated renal fibrosis in lncRNA Gas5-deficient mice after unilateral ureteric obstruction

Life Sci.

doi: 10.1016/j.lfs.2020.118656.

(IF 3.647)

839. Xiao Chen, Bing Shao, Chengmin Yu, Qunmei Yao, Peibin Ma, Haijiao Li, Bin Li, Chengye Sun

Energy disorders caused by mitochondrial dysfunction contribute to α-amatoxin-induced liver function damage and liver failure

Toxicol Lett.

doi: 10.1016/j.toxlet.2020.10.003.

(IF 3.569)

840. Hongfei Ge, Chao Zhang, Yang Yang, Weixiang Chen, Jun Zhong, Xuanyu Fang, Xuheng Jiang, Liang Tan, Yongjie Zou, Rong Hu, Yujie Chen, Hua Feng

Ambroxol Upregulates Glucocerebrosidase Expression to Promote Neural Stem Cells Differentiation Into Neurons Through Wnt/β-Catenin Pathway After Ischemic Stroke

Front Mol Neurosci.

doi: 10.3389/fnmol.2020.596039.

(IF 4.057)

841. Linjie Ju, Peipei Hu, Ping Chen, Jiejie Wu, Zhuoqun Li, Zhixia Qiu, Jun Cheng, Fang Huang

Corydalis Saxicola Bunting Total Alkaloids Attenuate Walker 256-Induced Bone Pain and Osteoclastogenesis by Suppressing RANKL-Induced NF-κB and c-Fos/NFATc1 Pathways in Rats

Front Pharmacol.

doi: 10.3389/fphar.2020.609119.

(IF 4.225)

842. Chaofan Wan, Yunlong Xu, Baoyan Cen, Yucen Xia, Lin Yao, Yuanjia Zheng, Jiaying Zhao, Su He, Yongjun Chen

Neuregulin1-ErbB4 Signaling in Spinal Cord Participates in Electroacupuncture Analgesia in Inflammatory Pain

Front Neurosci.

doi: 10.3389/fnins.2021.636348.

843. Yu Jiang, Qiuju Han, Huajun Zhao, Jian Zhang

Promotion of epithelial-mesenchymal transformation by hepatocellular carcinoma-educated macrophages through Wnt2b/β-catenin/c-Myc signaling and reprogramming glycolysis

J Exp Clin Cancer Res.

doi: 10.1186/s13046-020-01808-3.

844. Jingjie Liang, Kui Li, Kaiyu Chen, Junyong Liang, Ti Qin, Jiayi He, Shuang Shi, Qiang Tan, Zhengguang Wang

Regulation of ARHGAP19 in the endometrial epithelium: a possible role in the establishment of uterine receptivity

Reprod Biol Endocrinol.

doi: 10.1186/s12958-020-00689-7.

845. Ran Du, Feng Jiang, Yanhua Yin, Jinfen Xu, Xia Li, Likuan Hu, Xiuyu Wang

Knockdown of lncRNA X inactive specific transcript (XIST) radiosensitizes non-small cell lung cancer (NSCLC) cells through regulation of miR-16-5p/WEE1 G2 checkpoint kinase (WEE1) axis

Int J Immunopathol Pharmacol.

doi: 10.1177/2058738420966087.

846. Fei Zeng, Jierong Luo, Hong Han, Wenjie Xie, Lingzhi Wang, Ronghui Han, Hao Chen, Yin Cai, Huansen Huang, Zhengyuan Xia

Allopurinol ameliorates liver injury in type 1 diabetic rats through activating Nrf2

Int J Immunopathol Pharmacol.

doi: 10.1177/20587384211031417.

847. Weiping Shi, Danhua Ling, Feiyun Zhang, Xiaohui Fu, Danping Lai, Yanzhen Zhang

Curcumin promotes osteogenic differentiation of human periodontal ligament stem cells by inducting EGR1 expression

Arch Oral Biol.

doi: 10.1016/j.archoralbio.2020.104958.

(IF 1.931)

848. Hai-Peng Li, Ji-Ting Liu, Yuan-Xiu Chen, Wen-Bin Wang, Yue Han, Qing-Ping Yao, Ying-Xin Qi

Suppressed nuclear envelope proteins activate autophagy of vascular smooth muscle cells during cyclic stretch application

Biochim Biophys Acta Mol Cell Res.

doi: 10.1016/j.bbamcr.2020.118855.

849. Yingjun Zhang, Yuanlong An, Xiangdong He, Donglei Zhang, Wei He

Esculetin protects human corneal epithelial cells from oxidative stress through Nrf-2 signaling pathway

Exp Eye Res.

doi: 10.1016/j.exer.2020.108360.

(IF 3.011)

850. Hui Liu, Ling Zhang, Xiaoling Ding, Xuezuo Sui

LINC00861 inhibits the progression of cervical cancer cells by functioning as a ceRNA for miR‑513b‑5p and regulating the PTEN/AKT/mTOR signaling pathway

Mol Med Rep.

doi: 10.3892/mmr.2020.11662.

(IF 2.1)

851. Zhuang-Fei Chen, Ze-Hai Huang, Shi-Jun Chen, Yao-Dong Jiang, Zi-Ke Qin, Shao-Bin Zheng, Tong Chen

Oncogenic potential of macrophage‑capping protein in clear cell renal cell carcinoma

Mol Med Rep.

doi: 10.3892/mmr.2020.11718.

(IF 2.1)

852. Yao Xiong, Yan Wang, Ling Ma, Ying Zhang, Xinlan Qu, Lei Huang, Xue Wen, Huimin Liu, Ming Zhang, Yuanzhen Zhang

Mixed-lineage leukaemia 1 contributes to endometrial stromal cells progesterone responsiveness during decidualization

J Cell Mol Med.

doi: 10.1111/jcmm.16030.

(IF 4.486)

853. Cheng Li, Xiao Miao, Shudong Wang, Yucheng Liu, Jian Sun, Quan Liu, Lu Cai, Yonggang Wang

Elabela may regulate SIRT3-mediated inhibition of oxidative stress through Foxo3a deacetylation preventing diabetic-induced myocardial injury

J Cell Mol Med.

doi: 10.1111/jcmm.16052.

(IF 4.486)

854. Jiyu Chen, Yanli Huang, Xiaochuan Hu, Xiaohong Bian, Sihui Nian

Gastrodin prevents homocysteine-induced human umbilical vein endothelial cells injury via PI3K/Akt/eNOS and Nrf2/ARE pathway

J Cell Mol Med.

doi: 10.1111/jcmm.16073.

(IF 4.486)

855. Jia-Hui He, Rong-Pei Liu, Yi-Man Peng, Qing Guo, Lan-Bing Zhu, Yi-Zhi Lian, Bei-Lei Hu, Hui-Hui Fan, Xiong Zhang, Jian-Hong Zhu

Differential and paradoxical roles of new-generation antidepressants in primary astrocytic inflammation

J Neuroinflammation.

doi: 10.1186/s12974-021-02097-z.

856. Youxiang Zhang, De-Hui Xiong, Yangyang Li, Guina Xu, Baoxin Zhang, Yang Liu, Shan Zhang, Qing Huang, Simin Chen, Fansheng Zeng, Jingyi Guo, Bin Li, Zhiqiang Qin, Zuping Zhang

Schistosoma japonicum Infection in Treg-Specific USP21 Knockout Mice

J Immunol Res.

doi: 10.1155/2021/6613162.

(IF 3.327)

857. Li Zhang, Yujia Cui, Yueyi Yang, Jieya Wei, Wenjing Liu, Linyi Cai, Luling Wang, Demao Zhang, Jing Xie, Lei Cheng

The virulence factor GroEL promotes gelatinase secretion from cells in the osteoblast lineage: Implication for direct crosstalk between bacteria and adult cells

Arch Oral Biol.

doi: 10.1016/j.archoralbio.2020.104991.

(IF 1.931)

858. Yang Yang, Ying Li, Jie Wang, Lei Hong, Shigang Qiao, Chen Wang, Jianzhong An

Cholinergic receptors play a role in the cardioprotective effects of anesthetic preconditioning: Roles of nitric oxide and the CaMKKβ/AMPK pathway

Exp Ther Med.

doi: 10.3892/etm.2020.9569.

(IF 1.785)

859. Ping Zhang, Yang Wang, Mengting Qin, Dandan Li, Woodvine Otieno Odhiambo, Meng Yuan, Zhuangwei Lv, Chengcheng Liu, Yunfeng Ma, Yanying Dong, Yanhong Ji

Involvement of Blnk and Foxo1 in tumor suppression in BCR‑ABL1‑transformed pro‑B cells

Oncol Rep.

doi: 10.3892/or.2020.7888.

(IF 3.417)

860. Hui Li, Jian Zhang, Yongli Fu, Yixin Zhang, Chunhui Zhang, Xiaozhu Sun, Fang Wu, Jing He

Antidiabetic compounds 8a, 8b, 8k, and 9h enhance insulin secretion: activity and mechanism

Endocrine.

doi: 10.1007/s12020-020-02537-5.

(IF 3.235)

861. Qin Huang, Meng Gong, Tuantuan Tan, Yunong Lin, Yan Bao, Cuifang Fan

Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomal MicroRNA-18b-3p Inhibits the Occurrence of Preeclampsia by Targeting LEP

Nanoscale Res Lett.

doi: 10.1186/s11671-021-03475-5.

(IF 3.581)

862. Haocheng Ao, Haichun Li, Xiujuan Zhao, Bingqian Liu, Lin Lu

TXNIP positively regulates the autophagy and apoptosis in the rat müller cell of diabetic retinopathy

Life Sci.

doi: 10.1016/j.lfs.2020.118988.

(IF 3.647)

863. Wen Zhou, Deng Xiao, Yueyang Zhao, Botao Tan, Zhimin Long, Lehua Yu, Guiqiong He

Enhanced Autolysosomal Function Ameliorates the Inflammatory Response Mediated by the NLRP3 Inflammasome in Alzheimer's Disease

Front Aging Neurosci.

doi: 10.3389/fnagi.2021.629891.

(IF 4.362)

864. Jingyun Hu, Ming Cai, Qinghui Shang, Zhaorun Li, Yu Feng, Beibei Liu, Xiangli Xue, Shujie Lou

Elevated Lactate by High-Intensity Interval Training Regulates the Hippocampal BDNF Expression and the Mitochondrial Quality Control System

Front Physiol.

doi: 10.3389/fphys.2021.629914.

(IF 3.367)

865. Jinqiu Wang, Jing Xiao, Xin Liu, YuLing Gao, Zhang Luo, Xuedong Gu, Jiamin Zhang, Di Wu, Fang Geng

Tandem mass tag-labeled quantitative proteomic analysis of tenderloins between Tibetan and Yorkshire pigs

Meat Sci.

doi: 10.1016/j.meatsci.2020.108343.

(IF 3.644)

866. Youyang Wu, Wei Zhao, Fanhao Ye, Shiwei Huang, Hao Chen, Rui Zhou, Wenbing Jiang

Tetrandrine attenuates left ventricular dysfunction in rats with myocardial infarction

Exp Ther Med.

doi: 10.3892/etm.2020.9551.

(IF 1.785)

867. Ling Zhou, Zeming Liu, Sichao Chen, Jing Qiu, Qianqian Li, Shipei Wang, Wei Zhou, Danyang Chen, Guang Yang, Liang Guo

Transcription factor EB‑mediated autophagy promotes dermal fibroblast differentiation and collagen production by regulating endoplasmic reticulum stress and autophagy‑dependent secretion

Int J Mol Med.

doi: 10.3892/ijmm.2020.4814.

(IF 3.098)

868. Shi Chen, Kun Tang, Peiwu Hu, Shiyi Tan, Shang Yang, Chang Yang, Gang Chen, Yixiao Luo, Hui Zou

Atractylenolide III alleviates the apoptosis through inhibition of autophagy by the mTOR-dependent pathway in alveolar macrophages of human silicosis

Mol Cell Biochem.

doi: 10.1007/s11010-020-03946-w.

(IF 2.795)

869. Lijing Jiang, Jindi Ni, Guofeng Shen, Zhuye Xia, Lu Zhang, Shihong Xia, Shengfu Pan, Hongping Qu, Xiang Li

Upregulation of endothelial cell-derived exosomal microRNA-125b-5p protects from sepsis-induced acute lung injury by inhibiting topoisomerase II alpha

Inflamm Res.

doi: 10.1007/s00011-020-01415-0.

(IF 3.174)

870. Jing Wang, Jia Wang, Ling Li, Li Feng, Yu-Rong Wang, Zhe Wang, Ning-Hua Tan

RA-XII, a bicyclic hexapeptidic glucoside isolated from Rubia yunnanensis Diels, exerts antitumor activity by inhibiting protective autophagy and activating Akt-mTOR pathway in colorectal cancer cells

J Ethnopharmacol.

doi: 10.1016/j.jep.2020.113438.

(IF 3.69)

871. Jing Zhang, Xinru Yu, Chaojun Zhang, Qiong Zhang, Ying Sun, Heqin Zhu, Canming Tang

Pectin lyase enhances cotton resistance to Verticillium wilt by inducing cell apoptosis of Verticillium dahliae

J Hazard Mater.

doi: 10.1016/j.jhazmat.2020.124029.

(IF 9.038)

872. Hong-Ping Li, Xiao-Yu Wang, Chao Chen, Jing-Jing Li, Chi Yu, Li-Xue Lin, Zi-E Yu, Zhi-Yuan Jin, He Zhu, Hong-Chun Xiang, Xue-Fei Hu, Jie Cao, Xiang-Hong Jing, Man Li

100 Hz Electroacupuncture Alleviated Chronic Itch and GRPR Expression Through Activation of Kappa Opioid Receptors in Spinal Dorsal Horn

Front Neurosci.

doi: 10.3389/fnins.2021.625471.

873. Guanzhong Chen, Bowen Liu, Shiqun Chen, Huanqiang Li, Jin Liu, Ziling Mai, Enzhao Chen, Chunyun Zhou, Guoli Sun, Zhaodong Guo, Li Lei, Shanyi Huang, Liyao Zhang, Min Li, Ning Tan, Hong Li, Yulin Liao, Jia Liu, Jiyan Chen, Yong Liu

Novel biomarkers for post-contrast acute kidney injury identified from long non-coding RNA expression profiles

Int J Biol Sci.

doi: 10.7150/ijbs.45294.

(IF 4.858)

874. Shan He, Hanxiang Zhang, Yang Lu, Zhaosi Zhang, Xiang Zhang, Nian Zhou, Zhenming Hu

Nampt promotes osteogenic differentiation and lipopolysaccharide-induced interleukin-6 secretion in osteoblastic MC3T3-E1 cells

Aging (Albany NY).

doi: 10.18632/aging.202434.

875. Zhitao Li, Guoao Hu, Li Zhu, Zhenglong Sun, Yun Jiang, Min-Jie Gao, Xiaobei Zhan

Study of growth, metabolism, and morphology of Akkermansia muciniphila with an in vitro advanced bionic intestinal reactor

BMC Microbiol.

doi: 10.1186/s12866-021-02111-7.

(IF 2.989)

876. Qunyi Peng, Xiongpeng Zhu, Chuntuan Li, Pengliang Xin, Yan Zheng, Shengquan Liu

APDL1-CART cells exhibit strong PD-L1-specific activity against leukemia cells

Aging (Albany NY).

doi: 10.18632/aging.202578.

877. Junwen Cheng, Chaoyang Wei, Weiqi Li, Yanbin Wang, Shihao Wang, Qingrong Huang, Yu Liu, Liang He

Structural characteristics and enhanced biological activities of partially degraded arabinogalactan from larch sawdust

Int J Biol Macromol.

doi: 10.1016/j.ijbiomac.2021.01.039.

(IF 5.162)

878. Aping Niu, Wan-Ping Bian, Shuang-Long Feng, Shi-Ya Pu, Xing-Yi Wei, Yi-Fan Yang, Li-Yan Song, De-Sheng Pei

Role of manganese superoxide dismutase (Mn-SOD) against Cr(III)-induced toxicity in bacteria

J Hazard Mater.

doi: 10.1016/j.jhazmat.2020.123604.

(IF 9.038)

879. Xiaolong Tian, Jun Ma, Yijing Wu, Pan Zhang, Qinggang Li, Hao Zhang, Changxin Wu

Functional analysis of the brain natriuretic peptide gene for high-altitude adaptation in Tibetan pigs

Gene.

doi: 10.1016/j.gene.2020.145305.

(IF 2.984)

880. Qiongmei Xu, Jie Xu, Kefeng Zhang, Mingli Zhong, Houkang Cao, Riming Wei, Ling Jin, Ya Gao

Study on the protective effect and mechanism of Dicliptera chinensis (L.) Juss (Acanthaceae) polysaccharide on immune liver injury induced by LPS

Biomed Pharmacother.

doi: 10.1016/j.biopha.2020.111159.

(IF 4.545)

881. Wanyue Huang, Menglin Liu, Bonan Xiao, Jian Zhang, Miao Song, Yanfei Li, Zheng Cao

Aflatoxin B1 disrupts blood-testis barrier integrity by reducing junction protein and promoting apoptosis in mice testes

Food Chem Toxicol.

doi: 10.1016/j.fct.2021.111972.

(IF 4.679)

882. Lina Wu, Qingzhu Wang, Feng Guo, Xiaojun Ma, Jiao Wang, Yanyan Zhao, Yushan Yan, Guijun Qin

Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress

J Cell Physiol.

doi: 10.1002/jcp.29951.

(IF 5.546)

883. Imran Rashid Rajput, Summra Yaqoob, Sun Yajing, Edmond Sanganyado, Liu Wenhua

Polybrominated diphenyl ethers exert genotoxic effects in pantropic spotted dolphin fibroblast cell lines

Environ Pollut.

doi: 10.1016/j.envpol.2020.116131.

(IF 6.792)

884. Yanfa Dai, Jingyuan Nie, Zhongqin Luo, Dongsong Nie

Expression profile analysis of a new testis-specifically expressed gene C17ORF64 and its association with cell apoptosis in MCF-7 cells

Mol Biol Rep.

doi: 10.1007/s11033-021-06191-6.

(IF 1.402)

885. Zhaohui Shi, Min Xu, Xiaodong Chen, Jian Wang, Tianfeng Zhao, Dingjun Zha

The regulatory role of SFRP5/WNT5A axis in allergic rhinitis through inhibiting JNK pathway activation and lowering mucin generation in human nasal epithelial cells

Exp Mol Pathol.

doi: 10.1016/j.yexmp.2020.104591.

(IF 2.28)

886. Jing Lu, Cheng Cheng, Zhen-Chao Cheng, Qian Wu, Han Shen, Ming-Xia Yuan, Bo Zhang, Jin-Kui Yang

The dual role of RFX6 in directing β cell development and insulin production

J Mol Endocrinol.

doi: 10.1530/JME-20-0119.

(IF 3.562)

887. Chun Wang, Jie Luo, Zhihang Chen, Mingliang Ye, Yinghui Hong, Jialiang Liu, Jiayan Nie, Qiu Zhao, Ying Chang

MiR-375 Impairs the Invasive Capabilities of Hepatoma Cells by Targeting HIF1α Under Hypoxia

Dig Dis Sci.

doi: 10.1007/s10620-020-06202-9.

888. Chen-Yang Yuan, Tian-Xing Jing, Wei Li, Xiao-Qiang Liu, Tian-Yuan Liu, Yi Liu, Meng-Ling Chen, Rui-Xu Jiang, Guo-Rui Yuan, Wei Dou, Jin-Jun Wang

NADPH-cytochrome P450 reductase mediates the susceptibility of Asian citrus psyllid Diaphorina citri to imidacloprid and thiamethoxam

Pest Manag Sci.

doi: 10.1002/ps.6143.

(IF 3.75)

889. Bin Qi, Xiaowen Zhang, Hang Yu, Yandong Bao, Nan Wu, Dalin Jia

Brazilin prevents against myocardial ischemia-reperfusion injury through the modulation of Nrf2 via the PKC signaling pathway

Ann Transl Med.

doi: 10.21037/atm-20-4414.

(IF 3.297)

890. Dongli Yue, Shasha Liu, Tengfei Zhang, Yong Wang, Guohui Qin, Xinfeng Chen, Huanyu Zhang, Dong Wang, Dong Huang, Feng Wang, Liping Wang, Song Zhao, Yi Zhang

NEDD9 promotes cancer stemness by recruiting myeloid-derived suppressor cells via CXCL8 in esophageal squamous cell carcinoma

Cancer Biol Med.

doi: 10.20892/j.issn.2095-3941.2020.0290.

(IF 5.432)

891. Xiao Feng, Enfu Huang, Yuanyuan Gao, Ya Zhang, Yun Zhou

The effects of NONRATT008453.2 on autophagy in genital tubercle fibroblasts of rats with hypospadias induced by dibutyl phthalate

Birth Defects Res.

doi: 10.1002/bdr2.1863.

(IF 1.896)

892. H Guo, Y Wang, W Jia, L Liu

MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway

Physiol Res.

doi: 10.33549/physiolres.934506.

(IF 1.655)

893. Yajie Li, Xinliu Zeng, Dingheng Lu, Minuo Yin, Meirong Shan, Ying Gao

Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis

Hum Reprod.

doi: 10.1093/humrep/deaa363.

(IF 5.733)

894. Jun Li, Cuiting Zhao, Qing Zhu, Yonghuai Wang, Guangyuan Li, Xinxin Li, Yuhong Li, Nan Wu, Chunyan Ma

Sweroside Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress and Pyroptosis Partially via Modulation of the Keap1/Nrf2 Axis

Front Cardiovasc Med.

doi: 10.3389/fcvm.2021.650368.

895. Guangqi Liu, Dan Yan, Liu Yang, Yunwei Sun, Lin Zhan, Lili Lu, Zhigang Jin, Chunxiang Zhang, Ping Long, Jinhua Chen, Qiong Yuan

The effect of miR-471-3p on macrophage polarization in the development of diabetic cardiomyopathy

Life Sci.

doi: 10.1016/j.lfs.2020.118989.

(IF 3.647)

896. Yu-Peng Wu, Zhi-Bin Ke, Wen-Cai Zheng, Ye-Hui Chen, Jun-Ming Zhu, Fei Lin, Xiao-Dong Li, Shao-Hao Chen, Hai Cai, Qing-Shui Zheng, Yong Wei, Xue-Yi Xue, Ning Xu

Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells

Cell Death Dis.

doi: 10.1038/s41419-021-03582-2.

(IF 6.304)

897. Guoshu Bi, Donglin Zhu, Yunyi Bian, Yiwei Huang, Cheng Zhan, Yong Yang, Qun Wang

Knockdown of GTF2E2 inhibits the growth and progression of lung adenocarcinoma via RPS4X in vitro and in vivo

Cancer Cell Int.

doi: 10.1186/s12935-021-01878-z.

(IF 4.175)

898. Ting Huang, Xue Li, Fei Wang, Lihong Lu, Wenting Hou, Minmin Zhu, Changhong Miao

The CREB/KMT5A complex regulates PTP1B to modulate high glucose-induced endothelial inflammatory factor levels in diabetic nephropathy

Cell Death Dis.

doi: 10.1038/s41419-021-03629-4.

(IF 6.304)

899. Sheng Li, Di Qi, Jia-Ni Li, Xin-Yu Deng, Dao-Xin Wang

Vagus nerve stimulation enhances the cholinergic anti-inflammatory pathway to reduce lung injury in acute respiratory distress syndrome via STAT3

Cell Death Discov.

doi: 10.1038/s41420-021-00431-1.

900. Zilong Deng, Wenjuan Yan, Xingzhu Dai, Ming Chen, Qian Qu, Buling Wu, Wanghong Zhao

N-Cadherin Regulates the Odontogenic Differentiation of Dental Pulp Stem Cells via β-Catenin Activity

Front Cell Dev Biol.

doi: 10.3389/fcell.2021.661116.

(IF 5.201)

901. Guoyuan Pan, Jingyan Cheng, Weimin Shen, Yao Lin, Anqi Zhu, Lingqin Jin, Qingfeng Xie, Mingjin Zhu, Chan Liu, Fengxia Tu, Xiang Chen

Intensive treadmill training promotes cognitive recovery after cerebral ischemia-reperfusion in juvenile rats

Behav Brain Res.

doi: 10.1016/j.bbr.2020.113085.

(IF 2.977)

902. Ran Li, Qing Ruan, Jia Zheng, Butian Zhang, Hongliang Yang

LINC01116 Promotes Doxorubicin Resistance in Osteosarcoma by Epigenetically Silencing miR-424-5p and Inducing Epithelial-Mesenchymal Transition

Front Pharmacol.

doi: 10.3389/fphar.2021.632206.

(IF 4.225)

903. Min Li, Kun Fan, Bohao Zheng, David Zekria, Tao Suo, Han Liu, Sheng Shen, Houbao Liu, Xiaoling Ni

Knockdown of SLC39A4 Expression Inhibits the Proliferation and Motility of Gallbladder Cancer Cells and Tumor Formation in Nude Mice

Cancer Manag Res.

doi: 10.2147/CMAR.S282269.

(IF 2.886)

904. Yumeng Chen, Xingjia Fan, Xinqing Zhao, Yaling Shen, Xiangyang Xu, Liujing Wei, Wei Wang, Dongzhi Wei

cAMP activates calcium signalling via phospholipase C to regulate cellulase production in the filamentous fungus Trichoderma reesei

Biotechnol Biofuels.

doi: 10.1186/s13068-021-01914-0.

(IF 4.815)

905. Fan Chao, Zhenyu Song, Shiyu Wang, Zhe Ma, Zhiyuan Zhuo, Ting Meng, Guoxiong Xu, Gang Chen

Novel circular RNA circSOBP governs amoeboid migration through the regulation of the miR-141-3p/MYPT1/p-MLC2 axis in prostate cancer

Clin Transl Med.

doi: 10.1002/ctm2.360.

906. Peng Zheng, Yujun Liu, Xuejiao Liu, Yuqing Huang, Feng Sun, Wenyi Wang, Hao Chen, Mehmood Jan, Cuicui Zhang, Yue Yuan, Bao-Cai Tan, Hao Du, Jumin Tu

OsPPR939, a nad5 splicing factor, is essential for plant growth and pollen development in rice

Theor Appl Genet.

doi: 10.1007/s00122-020-03742-6.

(IF 4.439)

907. Xuliang Zhang, Yucong Wang, Xu Yang, Menglin Liu, Wanyue Huang, Jian Zhang, Miao Song, Bing Shao, Yanfei Li

The nephrotoxicity of T-2 toxin in mice caused by oxidative stress-mediated apoptosis is related to Nrf2 pathway

Food Chem Toxicol.

doi: 10.1016/j.fct.2021.112027.

(IF 4.679)

908. Xiao-Yu Dong, Xing Yuan, Ren-Jun Wang

Interaction of air cold plasma with Saccharomyces cerevisiae in the multi-scale microenvironment for improved ethanol yield

Bioresour Technol.

doi: 10.1016/j.biortech.2020.124621.

909. Fang Shen, Xiang Xu, Zhengquan Yu, Haiying Li, Haitao Shen, Xiang Li, Meifen Shen, Gang Chen

Rbfox-1 contributes to CaMKIIα expression and intracerebral hemorrhage-induced secondary brain injury via blocking micro-RNA-124

J Cereb Blood Flow Metab.

doi: 10.1177/0271678X20916860.

910. Xing Li, Bing Hu, Li Wang, Qingqing Xia, Xiuqin Ni

P2X7 receptor-mediated phenotype switching of pulmonary artery smooth muscle cells in hypoxia

Mol Biol Rep.

doi: 10.1007/s11033-021-06222-2.

(IF 1.402)

911. Dan-Dan Wang, Fang Wu, Ling-Yu Zhang, Ying-Cai Zhao, Cheng-Cheng Wang, Chang-Hu Xue, Teruyoshi Yanagita, Tian-Tian Zhang, Yu-Ming Wang

Effects of dietary n-3 PUFA levels in early life on susceptibility to high-fat-diet-induced metabolic syndrome in adult mice

J Nutr Biochem.

doi: 10.1016/j.jnutbio.2020.108578.

(IF 4.873)

912. Lisha Chang, Yunhe Zhang, Min Li, Xiaojing Zhao, Dali Wang, Jian Liu, Fuling Zhou, Jiang Zhang

Nanostructured lipid carrier co-delivering paclitaxel and doxorubicin restrains the proliferation and promotes apoptosis of glioma stem cells via regulating PI3K/Akt/mTOR signaling

Nanotechnology.

doi: 10.1088/1361-6528/abd439.

(IF 3.551)

913. Xiaobao Gong, Hong Tang, Kai Yang

PER1 suppresses glycolysis and cell proliferation in oral squamous cell carcinoma via the PER1/RACK1/PI3K signaling complex

Cell Death Dis.

doi: 10.1038/s41419-021-03563-5.

(IF 6.304)

914. Fang Qu, Yingshuang Song, Yaqin Wu, Yujie Huang, Qi Zhong, Yifan Zhang, Zhen Fan, Chun Xu

The protective role of Ephrin-B2/EphB4 signaling in osteogenic differentiation under inflammatory environment

Exp Cell Res.

doi: 10.1016/j.yexcr.2021.112505.

(IF 3.383)

915. Fengming Chen, Jiayi Chen, Qinghua Chen, Lingyuan Yang, Jie Yin, Yinghui Li, Xingguo Huang

Lactobacillus delbrueckii Protected Intestinal Integrity, Alleviated Intestinal Oxidative Damage, and Activated Toll-Like Receptor-Bruton's Tyrosine Kinase-Nuclear Factor Erythroid 2-Related Factor 2

Antioxidants (Basel).

doi: 10.3390/antiox10030468.

916. Dazhuang Yi, Qunhui Wang, Yuhao Zhao, Yu Song, Hong You, Jian Wang, Renjie Liu, Zhongqiang Shi, Xuan Chen, Qi Luo

Alteration of N 6 -Methyladenosine mRNA Methylation in a Rat Model of Cerebral Ischemia-Reperfusion Injury

Front Neurosci.

doi: 10.3389/fnins.2021.605654.

917. Huiling Li, Yihan Chen, Qiaofeng Jin, Ya Wu, Cheng Deng, Yongkang Gai, Zhenxing Sun, Yuman Li, Jing Wang, Yali Yang, Qing Lv, Yongxue Zhang, Rui An, Xiaoli Lan, Li Zhang, Mingxing Xie

Noninvasive Radionuclide Molecular Imaging of the CD4-Positive T Lymphocytes in Acute Cardiac Rejection

Mol Pharm.

doi: 10.1021/acs.molpharmaceut.0c01155.

918. Xiaolei Yao, M A Ei-Samahy, Shenhua Xiao, Zhibo Wang, Fanxing Meng, Xiaodan Li, Yongjin Bao, Yanli Zhang, Ziyu Wang, Yixuan Fan, Feng Wang

CITED4 mediates proliferation, apoptosis and steroidogenesis of Hu sheep granulosa cells in vitro

Reproduction.

doi: 10.1530/REP-20-0427.

(IF 3.206)

919. Xin-Sen Zou, Lu Xie, Wen-Yan Wang, Gao-Yang Zhao, Xin-Yue Tian, Meng-Hua Chen

Pomelo peel oil alleviates cerebral NLRP3 inflammasome activation in a cardiopulmonary resuscitation rat model

Exp Ther Med.

doi: 10.3892/etm.2021.9664.

(IF 1.785)

920. Xin-Yi Liu, Xue-Jiao Chen, Miao Zhao, Zhi-Qiang Wang, Hai-Zhu Chen, Hong-Fu Li, Chen-Ji Wang, Shi-Fei Wu, Chao Peng, Yue Yin, Hong-Xia Fu, Min-Ting Lin, Long Yu, Zhi-Qi Xiong, Zhi-Ying Wu, Ning Wang

CHIP control degradation of mutant ETF:QO through ubiquitylation in late-onset multiple acyl-CoA dehydrogenase deficiency

J Inherit Metab Dis.

doi: 10.1002/jimd.12361.

(IF 4.036)

921. Xuancheng Zhang, Zhuochang Cai, Minghu Wu, Xiaoqiao Huangfu, Juehong Li, Xudong Liu

Adipose Stem Cell-Derived Exosomes Recover Impaired Matrix Metabolism of Torn Human Rotator Cuff Tendons by Maintaining Tissue Homeostasis

Am J Sports Med.

doi: 10.1177/0363546521992469.

922. Zuping Wu, Chenchen Zhou, Quan Yuan, Demao Zhang, Jing Xie, Shujuan Zou

CTGF facilitates cell-cell communication in chondrocytes via PI3K/Akt signalling pathway

Cell Prolif.

doi: 10.1111/cpr.13001.

923. Lin Li, Haiyan Gan, Huaqian Jin, Yan Fang, Yan Yang, Jianping Zhang, Xiaowei Hu, Lisheng Chu

Astragaloside IV promotes microglia/macrophages M2 polarization and enhances neurogenesis and angiogenesis through PPARγ pathway after cerebral ischemia/reperfusion injury in rats

Int Immunopharmacol.

doi: 10.1016/j.intimp.2020.107335.

(IF 3.943)

924. Xintong Jia, Bin Sun, Qiu Tu, Huaxin Qi, Lin Li, Xiuyun Liu, Lanzhen Yan, Hongjuan Dai, Qingpeng Kong, Chengwei Tang, Xudong Zhao

Smad4 deficiency substitutes Cdkn2b but not Cdkn2a downregulation in pancreatic cancer following induction of genetic events in adult mice

Pancreatology.

doi: 10.1016/j.pan.2021.01.004.

(IF 3.629)

925. Chong Wang, Ying Feng, Wen-Jing Zhou, Zhao-Jun Cheng, Mei-Yan Jiang, Yan Zhou, Xiao-Yang Fei

Screening and identification of endometrial proteins as novel potential biomarkers for repeated implantation failure

PeerJ.

doi: 10.7717/peerj.11009.

(IF 2.379)

926. Dandan Wu, Yufeng Zhu

Role of kynurenine in promoting the generation of exhausted CD8+ T cells in colorectal cancer

Am J Transl Res.

(IF 3.375)

927. Jinguo Wang, Sheng Xie, Jun Liu, Tao Li, Wanrong Wang, Ziping Xie

MicroRNA-4429 suppresses proliferation of prostate cancer cells by targeting distal-less homeobox 1 and inactivating the Wnt/β-catenin pathway

BMC Urol.

doi: 10.1186/s12894-021-00810-x.

(IF 1.592)

928. Yanfei Yang, Yabin Li, Jinli Han, Yanfen Wang

Gastrodin attenuates lithium-pilocarpine-induced epilepsy by activating AMPK-mediated PPARα in a juvenile rat model

Biosci Biotechnol Biochem.

doi: 10.1093/bbb/zbab013.

929. Wei Yuan, Liaoxun Lu, Muding Rao, Yang Huang, Chun-E Liu, Shuang Liu, Yue Zhao, Huicong Liu, Jiangli Zhu, Tianzhu Chao, Can Wu, Junyan Ren, Luxian Lv, Wenqiang Li, Shiqian Qi, Yinming Liang, Shijing Yue, Jian Gao, Zhongjian Zhang, Eryan Kong

GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice

Proc Natl Acad Sci U S A.

doi: 10.1073/pnas.2022261118.

930. Wei Zhao, Youyang Wu, Fanhao Ye, Shiwei Huang, Hao Chen, Rui Zhou, Wenbing Jiang

Tetrandrine Ameliorates Myocardial Ischemia Reperfusion Injury through miR-202-5p/TRPV2

Biomed Res Int.

doi: 10.1155/2021/8870674.

(IF 2.276)

931. Weimin Shen, Lingqin Jin, Anqi Zhu, Yao Lin, Guoyuan Pan, Shanshan Zhou, Jingyan Cheng, Jieqiong Zhang, Fengxia Tu, Chan Liu, Qingfeng Xie, Xiang Chen

Treadmill exercise enhances synaptic plasticity in the ischemic penumbra of MCAO mice by inducing the expression of Camk2a via CYFIP1 upregulation

Life Sci.

doi: 10.1016/j.lfs.2021.119033.

(IF 3.647)

932. Jiye Chen, Yongjian Zhang, Yongcheng Wang, Ping Jiang, Guofeng Zhou, Zhaoyu Li, Jinlong Yang, Xiao Li

Potential mechanisms of Guizhi decoction against hypertension based on network pharmacology and Dahl salt-sensitive rat model

Chin Med.

doi: 10.1186/s13020-021-00446-x.

933. J Y Fu, C X Jiang, M Y Wu, R Y Mei, A F Yang, H P Tao, X J Chen, J Zhang, L Huang, X F Zhao

Theabrownin Induces Cell Apoptosis and Cell Cycle Arrest of Oligodendroglioma and Astrocytoma in Different Pathways

Front Pharmacol.

doi: 10.3389/fphar.2021.664003.

(IF 4.225)

934. Peng Xiao, Yu-Kang Liu, Wei Han, Yan Hu, Bo-You Zhang, Wen-Liang Liu

Exosomal Delivery of FTO Confers Gefitinib Resistance to Recipient Cells through ABCC10 Regulation in an m6A-dependent Manner

Mol Cancer Res.

doi: 10.1158/1541-7786.MCR-20-0541.

(IF 4.63)

935. Yu Liu, Lili Zou, Peng Wang, Jingxuan Zhou, Chunling Yuan, Jun Wang

Construction of differential expression plasmids of NGF to detect its influence on PC12 cell neuronal differentiation

Exp Ther Med.

doi: 10.3892/etm.2021.9794.

(IF 1.785)

936. Yan Zhang, Xiaomei Yang, Shuang Wang, Shuang Song, Xiudong Yang

Gentiopicroside prevents alcoholic liver damage by improving mitochondrial dysfunction in the rat model

Phytother Res.

doi: 10.1002/ptr.6981.

(IF 4.087)

937. Zhan Ye, Yong-Jiang Xu, Yuanfa Liu

Influence of different dietary oil consumption on nutrient malabsorption: An animal trial using Sprague Dawley rats

J Food Biochem.

doi: 10.1111/jfbc.13695.

(IF 1.662)

938. Yong Wang, Rongfen Gao, Jinpeng Li, Shaotao Tang, Shuai Li, Qiangsong Tong, Shiwang Li

Downregulation of hsa_circ_0074854 Suppresses the Migration and Invasion in Hepatocellular Carcinoma via Interacting with HuR and via Suppressing Exosomes-Mediated Macrophage M2 Polarization

Int J Nanomedicine.

doi: 10.2147/IJN.S284560.

939. Da Zhong, Gan-Zhe Xu, Ju-Zhi Wu, Hua Liu, Ju-Yu Tang, Cheng-Gong Wang

Circ-ITCH sponges miR-214 to promote the osteogenic differentiation in osteoporosis via upregulating YAP1

Cell Death Dis.

doi: 10.1038/s41419-021-03586-y.

(IF 6.304)

940. Yu Cai, Mingtian Deng, Qifan Zhang, Zifei Liu, Liang Wang, Wenwen Sheng, Yanli Zhang, Peihua You, Ziyu Wang, Feng Wang

Effects of dietary betaine supplementation on biochemical parameters of blood and testicular oxidative stress in Hu sheep

Theriogenology.

doi: 10.1016/j.theriogenology.2021.01.006.

(IF 2.094)

941. Shanshan Xu, Xuefeng Xu, Ziming Zhang, Lingling Yan, Liyan Zhang, Lizhong Du

The role of RNA m6A methylation in the regulation of postnatal hypoxia-induced pulmonary hypertension

Respir Res.

doi: 10.1186/s12931-021-01728-6.

942. Shaozhi Hou, Yang Song, Di Sun, Shujun Zhu, Zhenhua Wang

Xanthohumol-Induced Rat Glioma C6 Cells Death by Triggering Mitochondrial Stress

Int J Mol Sci.

doi: 10.3390/ijms22094506.

(IF 4.556)

943. Xiang Wang, Srinivasan Balamurugan, Si-Fen Liu, Chang-Yang Ji, Yu-Hong Liu, Wei-Dong Yang, Liwen Jiang, Hong-Ye Li

Hydrolysis of organophosphorus by diatom purple acid phosphatase and sequential regulation of cell metabolism

J Exp Bot.

doi: 10.1093/jxb/erab026.

(IF 5.908)

944. Qun Zhao, Jian Guo, Xinran Cheng, Yingying Liao, Yun Bi, Yingxia Gong, Xudong Zhang, Yang Guo, Xianhui Wang, Wei Yu, Shu Jin, Yan Tan, Xianjun Yu

RIPK3 Suppresses the Progression of Spontaneous Intestinal Tumorigenesis

Front Oncol.

doi: 10.3389/fonc.2021.664927.

(IF 4.848)

945. Cong Han, Yue-Hua Jiang, Wei Li, Yao Liu

Astragalus membranaceus and Salvia miltiorrhiza ameliorates cyclosporin A-induced chronic nephrotoxicity through the "gut-kidney axis"

J Ethnopharmacol.

doi: 10.1016/j.jep.2020.113768.

(IF 3.69)

946. Yan Wang, Jianji Gao, Fan Wu, Caiyun Lai, Yueqi Li, Gaoqiang Zhang, Xinyue Peng, Susu Yu, Jiani Yang, Wei Wang, Wenjuan Zhang, Xingfen Yang

Biological and epigenetic alterations of mitochondria involved in cellular replicative and hydrogen peroxide-induced premature senescence of human embryonic lung fibroblasts

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2021.112204.

947. Pan Wang, Hai-Juan Sui, Xiao-Jia Li, Li-Na Bai, Jing Bi, Hong Lai

Melatonin ameliorates microvessel abnormalities in the cerebral cortex and hippocampus in a rat model of Alzheimer's disease

Neural Regen Res.

doi: 10.4103/1673-5374.295349.

(IF 3.171)

948. Yan Yang, Chen Zhang, Shu Li, Jialun Liu, Yiyu Qin, Anxing Ge

Tissue factor pathway inhibitor 2 suppresses the growth of thyroid cancer cells through by induction of apoptosis

Asia Pac J Clin Oncol.

doi: 10.1111/ajco.13298.

949. Ling Zhang, Jin Zhang, Shujing Li, Yanyan Zhang, Yun Liu, Jian Dong, Wenjun Zhao, Bo Yu, Huifang Wang, Jing Liu

Genomic amplification of long noncoding RNA HOTAIRM1 drives anaplastic thyroid cancer progression via repressing miR-144 biogenesis

RNA Biol.

doi: 10.1080/15476286.2020.1819670.

(IF 5.35)

950. Guohong Shi, Zhen Zhang

Rap2B promotes the proliferation and migration of human glioma cells via activation of the ERK pathway

Oncol Lett.

doi: 10.3892/ol.2021.12575.

(IF 2.311)

951. Bin Li, Pei-Jun Xie, Yan-Wei Hao, Yu Guo, Jun-Rong Yu, Dao-Yin Gong, Jing Guo, Jin-Hao Zeng, Yi Zhang

Yuan‑zhi‑san inhibits tau protein aggregation in an Aβ1‑40‑induced Alzheimer's disease rat model via the ubiquitin‑proteasome system

Mol Med Rep.

doi: 10.3892/mmr.2021.11918.

(IF 2.1)

952. Hao Liu, Changying Wang, Gen Liu, Yanping Li, Li Kang, Yi Sun, Yunliang Jiang

A 14 bp indel polymorphism in the promoter region is associated with different responses to porcine circovirus type 2 infection by regulating MRC1 transcription

Vet Immunol Immunopathol.

doi: 10.1016/j.vetimm.2021.110202.

953. Haoran Zhang, Shixuan Zhuo, Danni Song, Leyao Wang, Junyi Gu, Junyan Ma, Yang Gu, Minghui Ji, Meijuan Chen, Yuanyuan Guo

Icariin Inhibits Intestinal Inflammation of DSS-Induced Colitis Mice Through Modulating Intestinal Flora Abundance and Modulating p-p65/p65 Molecule

Turk J Gastroenterol.

doi: 10.5152/tjg.2021.20282.

(IF 1.111)

954. Xianjing Zheng, Haimei Liu, Maoqiang Ma, Jianbo Ji, Faliang Zhu, Longru Sun

Anti-thrombotic activity of phenolic acids obtained from Salvia miltiorrhiza f. alba in TNF-α-stimulated endothelial cells via the NF-κB/JNK/p38 MAPK signaling pathway

Arch Pharm Res.

doi: 10.1007/s12272-021-01325-7.

(IF 2.934)

955. Yaoguang Gu, Xiang Xiao, Ruirong Pan, Jiayan Zhang, Yansheng Zhao, Ying Dong, Henglin Cui

Lactobacillus plantarum dy-1 fermented barley extraction activates white adipocyte browning in high-fat diet-induced obese rats

J Food Biochem.

doi: 10.1111/jfbc.13680.

(IF 1.662)

956. Yuqi Zhou, Xiangyong Li, Min Ye

Morusin inhibits the growth of human colorectal cancer HCT116‑derived sphere‑forming cells via the inactivation of Akt pathway

Int J Mol Med.

doi: 10.3892/ijmm.2021.4884.

(IF 3.098)

957. Jun Miao, Bo Wang, Ran Shao, Yan Wang

CircUSP36 knockdown alleviates oxidized low‑density lipoprotein‑induced cell injury and inflammatory responses in human umbilical vein endothelial cells via the miR‑20a‑5p/ROCK2 axis

Int J Mol Med.

doi: 10.3892/ijmm.2021.4873.

(IF 3.098)

958. Qingling Wang, Wenjuan Wang, Aihau Zhang

TET-mediated DNA demethylation plays an important role in arsenic-induced HBE cells oxidative stress via regulating promoter methylation of OGG1 and GSTP1

Toxicol In Vitro.

doi: 10.1016/j.tiv.2020.105075.

(IF 2.959)

959. Kai Zhu, Ying Li, Yikai Xu

The FTO m 6 A demethylase inhibits the invasion and migration of prostate cancer cells by regulating total m 6 A levels

Life Sci.

doi: 10.1016/j.lfs.2021.119180.

(IF 3.647)

960. Jie Wan, Chu-Meng Shen, Yu Wang, Qing-Zi Wu, Yi-Lei Wang, Qiang Liu, Yi-Man Sun, Jun-Ping Cao, Yu-Qing Wu

Repeated exposure to propofol in the neonatal period impairs hippocampal synaptic plasticity and the recognition function of rats in adulthood

Brain Res Bull.

doi: 10.1016/j.brainresbull.2021.01.007.

(IF 3.37)

961. Dongfang Tang, Tao Huang, Qilong Tian, Julei Wang

MYC/NBS1-Mediated DNA Damage Response is Involved in the Inhibitory Effect of Hydroxysafflor Yellow A on Glioma Cells

Drug Des Devel Ther.

doi: 10.2147/DDDT.S288841.

962. Yali Chen, Mengchan Ou, Xuechao Hao, Peng Liang, Yan Liang, Yangyang Wang, Yu Li, Cheng Zhou

Sub-chronic exposure to morphine alters general anesthetic potency by differentially regulating the expression of neurotransmitter receptor subunits in mice

Brain Res Bull.

doi: 10.1016/j.brainresbull.2021.01.009.

(IF 3.37)

963. Datong Sun, Shenghui Yang, Xufeng Zhang, Sai Li, Lin Wang, Junmin Chen, Chun Qiu, Ke Xu

Forkhead box protein O3a promotes glioma cell resistance to temozolomide by regulating matrix metallopeptidase and β-catenin

Oncol Lett.

doi: 10.3892/ol.2021.12580.

(IF 2.311)

964. Yinghua Li, Jian Zhou

USP5 Promotes Uterine Corpus Endometrial Carcinoma Cell Growth and Migration via mTOR/4EBP1 Activation

Cancer Manag Res.

doi: 10.2147/CMAR.S290467.

(IF 2.886)

965. Yicheng Tian, Jian Gou, He Zhang, Jinghan Lu, Zhuangzhuang Jin, Shuangshuo Jia, Lunhao Bai

The anti-inflammatory effects of 15-HETE on osteoarthritis during treadmill exercise

Life Sci.

doi: 10.1016/j.lfs.2021.119260.

(IF 3.647)

966. Ying Xiao, Lei Xie, Qi-Ya Xu, Li Chen, Huan Chen, Guang-Yin Xu, Ping-An Zhang

Transcranial direct current stimulation relieves visceral hypersensitivity via normalizing GluN2B expression and neural activity in anterior cingulate cortex

J Neurophysiol.

doi: 10.1152/jn.00025.2021.

(IF 2.225)

967. Ziqing Wang, Wenwen Mu, Pengxiao Li, Guoyun Liu, Jie Yang

Anti-inflammatory activity of ortho-trifluoromethoxy-substituted 4-piperidione-containing mono-carbonyl curcumin derivatives in vitro and in vivo

Eur J Pharm Sci.

doi: 10.1016/j.ejps.2021.105756.

(IF 3.616)

968. Yanan Ding, Longlin Zhang, Xiaofeng Yao, Haihan Zhang, Xi He, Zhiyong Fan, Zehe Song

Honokiol Alleviates High-Fat Diet-Induced Obesity of Mice by Inhibiting Adipogenesis and Promoting White Adipose Tissue Browning

Animals (Basel).

doi: 10.3390/ani11061493.

969. Qingqing Yin, Tong Du, Chunlin Yang, Xiaoli Li, Zeyu Zhao, Rutao Liu, Bing Yang, Bin Liu

Gadd45b is a novel mediator of depression-like behaviors and neuroinflammation after cerebral ischemia

Biochem Biophys Res Commun.

doi: 10.1016/j.bbrc.2021.03.104.

970. Juanjuan Zhang, Ying Xu, Ying Zhao, Jingkun Bai, Mengge Xu, Chuanji Li, Jinyue Li, Yong Ren, Chang Xu, Yuguang Gao, Yan Sun, Xiaoying Liu

The absence of muscle segment homeobox 2 leads to the pyroptosis of ameloblasts by inducing squamous epithelial hyperplasia in the enamel organ

J Cell Mol Med.

doi: 10.1111/jcmm.16646.

(IF 4.486)

971. Yang Guo, Youbing Wu, Jiahao Shi, Hua Zhuang, Lei Ci, Qin Huang, Zhipeng Wan, Hua Yang, Mengjie Zhang, Yutong Tan, Ruilin Sun, Leon Xu, Zhugang Wang, Ruling Shen, Jian Fei

miR-29a/b1 Regulates the Luteinizing Hormone Secretion and Affects Mouse Ovulation

Front Endocrinol (Lausanne).

doi: 10.3389/fendo.2021.636220.

972. Zuotian Wu, Gaohua Wang, Lin Zhou, Limin Sun, Yumeng Xie, Ling Xiao

Neuroinflammation decreased hippocampal microtubule dynamics in the acute behavioral deficits induced by intracerebroventricular injection of lipopolysaccharide in male adult rats

Neuroreport.

doi: 10.1097/WNR.0000000000001638.

(IF 1.394)

973. Hang Deng, Liugen Zeng, Kaile Chang, Yangfeng Lv, Hailing Du, Shina Lu, Yapeng Liu, Pengcheng Zhou, Huiling Mao, Chengyu Hu

Grass carp (Ctenopharyngodon idellus) Cdc25a down-regulates IFN 1 expression by reducing TBK1 phosphorylation

Dev Comp Immunol.

doi: 10.1016/j.dci.2021.104014.

(IF 3.192)

974. Mengyuan Li, Wen Xue, Xinhua Li, Yaxiang Song, Xinying Liu, Ling Qin

Axl is related to inflammation in hemodialysis patients

Mol Immunol.

doi: 10.1016/j.molimm.2021.02.024.

(IF 3.641)

975. Wuxue Peng, Xi Liu, Changhong Tan, Wen Zhou, Jin Jiang, Xuan Zhou, Juncong Du, Lijuan Mo, Lifen Chen

Zinc-α2-glycoprotein relieved seizure-Induced neuronal glucose uptake impairment via insulin-like growth factor 1 receptor-regulated glucose transporter 3 expression

J Neurochem.

doi: 10.1111/jnc.15254.

(IF 4.066)

976. Yang Yang, Ying Xiong, Hong-Fei Li, Huai-Jia Zhao, Guang-Hui Tang, Li-Wei Meng, Jin-Jun Wang, Hong-Bo Jiang

The adipokinetic hormone signaling system regulates the sensitivity of Bactrocera dorsalis to malathion

Pestic Biochem Physiol.

doi: 10.1016/j.pestbp.2021.104808.

977. Likun Yang, Xifeng Zhang, Xiufen Liu

Long non‑coding RNA GAS5 protects against Mycoplasma pneumoniae pneumonia by regulating the microRNA‑222‑3p/TIMP3 axis

Mol Med Rep.

doi: 10.3892/mmr.2021.12019.

(IF 2.1)

978. Yan Liu, Shuting Li, Yao Liu, Xujing Lv, Qing Zhou

MicroRNA-124 facilitates lens epithelial cell apoptosis by inhibiting SPRY2 and MMP-2

Mol Med Rep.

doi: 10.3892/mmr.2021.12020.

(IF 2.1)

979. Wei Guo, Zi-Yang Tang, Zhen-Yu Cai, Wen-E Zhao, Jin Yang, Xi-Peng Wang, Juan Ji, Xin-Xin Huang, Xiu-Lan Sun

Iptakalim alleviates synaptic damages via targeting mitochondrial ATP-sensitive potassium channel in depression

FASEB J.

doi: 10.1096/fj.202100124RR.

(IF 4.966)

980. Jiefeng Geng, Haibiao Zhao, Xing Liu, Junjie Geng, Yuyuan Gao, Bingzheng He

MiR-101a-3p Attenuated Pilocarpine-Induced Epilepsy by Downregulating c-FOS

Neurochem Res.

doi: 10.1007/s11064-021-03245-w.

(IF 3.038)

981. Suoli Cheng, Xueqin Liu, Fan Gong, Xiaoling Ding, Xuebing Zhou, Cuiyun Liu, Fei Zhao, Xiaoliang Li, Jiandang Shi

Dexamethasone promotes the endoplasmic reticulum stress response of bone marrow mesenchymal stem cells by activating the PERK-Nrf2 signaling pathway

Pharmacol Res Perspect.

doi: 10.1002/prp2.791.

982. Jiayan Chen, Liping Lu, Chunlong Zhang, Xiaoming Zhu, Shulin Zhuang

Endothelial dysfunction and transcriptome aberration in mouse aortas induced by black phosphorus quantum dots and nanosheets

Nanoscale.

doi: 10.1039/d1nr01965a.

(IF 6.895)

983. Wenli Luo, Li Li, Weina Xu, Jing Zhang, Jianxiong Xu

Toxic Effects of Docosahexaenoic Acid Treatment in the Rat Liver BRL-3A Cell

Toxics.

doi: 10.3390/toxics9050112.

984. Xiao-Fei Zhang, Jian-Xiong Ma, Yuan-Lin Wang, Xin-Long Ma

Calcyclin (S100A6) Attenuates Inflammatory Response and Mediates Apoptosis of Chondrocytes in Osteoarthritis via the PI3K/AKT Pathway

Orthop Surg.

doi: 10.1111/os.12990.

(IF 1.718)

985. Aonan Pan, Yue Li, Jian Guan, Pengxia Zhang, Chunbin Zhang, Yupeng Han, Tao Zhang, Yao Cheng, Luo Sun, Shizhen Lu, Jinru Weng, Qiaosheng Ren, Shengjie Fan, Weiqun Wang, Jingtao Wang

USP18-deficiency in cervical carcinoma is crucial for the malignant behavior of tumor cells in an ERK signal-dependent manner

Oncol Lett.

doi: 10.3892/ol.2021.12682.

(IF 2.311)

986. Hui-Li Wang, Guang-Dong Xing, Yong Qian, Xue-Feng Sun, Ji-Feng Zhong, Kun-Lin Chen

Dihydromyricetin attenuates heat stress-induced apoptosis in dairy cow mammary epithelial cells through suppressing mitochondrial dysfunction

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2021.112078.

987. Jun-Hua Huang, Hua Duan, Sha Wang, Yi-Yi Wang

Estrogen 17β‑estradiol accelerates the proliferation of uterine junctional zone smooth muscle cells via the let‑7a/Lin28B axis in adenomyosis

Mol Med Rep.

doi: 10.3892/mmr.2021.11976.

(IF 2.1)

988. Zhen Lan, Zhaoyou Meng, Biyao Lian, Mengying Liu, Tao Sun, Huan Sun, Zhi Liu, Zhenxin Hu, Qiang Guo, Jiqiang Zhang

Hippocampal Aromatase Knockdown Aggravates Ovariectomy-Induced Spatial Memory Impairment, Aβ Accumulation and Neural Plasticity Deficiency in Adult Female Mice

Neurochem Res.

doi: 10.1007/s11064-021-03258-5.

(IF 3.038)

989. Ran Tian, Xin Guan, Hao Qian, Liang Wang, Zhujun Shen, Ligang Fang, Zhenyu Liu

Restoration of NRF2 attenuates myocardial ischemia reperfusion injury through mediating microRNA-29a-3p/CCNT2 axis

Biofactors.

doi: 10.1002/biof.1712.

(IF 4.734)

990. Yuhua Li, Na Wang, Zhongliang Ma, Yunwen Wang, Yuan Yuan, Zhitao Zhong, Yi Hong, Min Zhao

Lipoxin A4 protects against paraquat‑induced acute lung injury by inhibiting the TLR4/MyD88‑mediated activation of the NF‑κB and PI3K/AKT pathways

Int J Mol Med.

doi: 10.3892/ijmm.2021.4919.

(IF 3.098)

991. Huimin Lu, Yanchao Ma, Mingyuan Wang, Jin Shen, Hongya Wu, Juntao Li, Nan Gao, Yanzheng Gu, Xueguang Zhang, Guangbo Zhang, Tongguo Shi, Weichang Chen

B7-H3 confers resistance to Vγ9Vδ2 T cell-mediated cytotoxicity in human colon cancer cells via the STAT3/ULBP2 axis

Cancer Immunol Immunother.

doi: 10.1007/s00262-020-02771-w.

992. Zhicheng Zhao, Li Lu, Weidong Li

N-(3',4'-dimethoxycinnamonyl) anthranilic acid alleviates severe acute pancreatitis by inhibiting intestinal barrier dysfunction and NF-κB activation

Drug Dev Res.

doi: 10.1002/ddr.21769.

993. Li Zhou, Xinrong Tao, Gang Pang, Min Mu, Qixian Sun, Fei Liu, Yuting Hu, Huihui Tao, Bing Li, Keyi Xu

Maternal Nicotine Exposure Alters Hippocampal Microglia Polarization and Promotes Anti-inflammatory Signaling in Juvenile Offspring in Mice

Front Pharmacol.

doi: 10.3389/fphar.2021.661304.

(IF 4.225)

994. Wenfei Zhang, Liang Xiong, Jiaming Chen, Zhezhe Tian, Jiaxin Liu, Fang Chen, Man Ren, Wutai Guan, Shihai Zhang

Artemisinin Protects Porcine Mammary Epithelial Cells against Lipopolysaccharide-Induced Inflammatory Injury by Regulating the NF-κB and MAPK Signaling Pathways

Animals (Basel).

doi: 10.3390/ani11061528.

995. Li Zhang, Xiufen Chen, Mingxiu Chang, Boning Jiao

MiR-30c-5p/ATG5 Axis Regulates the Progression of Parkinson's Disease

Front Cell Neurosci.

doi: 10.3389/fncel.2021.644507.

(IF 3.921)

996. Hai-Rong Zhang, Shi-Yong Wu, Zhong-Xue Fu

LncRNA-cCSC1 promotes cell proliferation of colorectal cancer through sponging miR-124-3p and upregulating CD44

Biochem Biophys Res Commun.

doi: 10.1016/j.bbrc.2021.04.018.

997. Chao Hu, Yuzhen Li, Danting Pan, Jing Wang, Liufang Zhu, Yu Lin, Shanli Zhu, Weiqing Pan

A Schistosoma japonicum MicroRNA Exerts Antitumor Effects Through Inhibition of Both Cell Migration and Angiogenesis by Targeting PGAM1

Front Oncol.

doi: 10.3389/fonc.2021.652395.

(IF 4.848)

998. Jin Wang, Lirong Tan, Beibei Jia, Xiaofan Yu, Ruixin Yao, Nan OUYang, Xueting Yu, Xiyuan Cao, Jian Tong, Tao Chen, Rui Chen, Jianxiang Li

Downregulation of m6A Reader YTHDC2 Promotes the Proliferation and Migration of Malignant Lung Cells via CYLD/NF-κB Pathway

Int J Biol Sci.

doi: 10.7150/ijbs.58514.

(IF 4.858)

999. Chaochao Luo, Wanwan Peng, Jia Kang, Caiming Chen, Jiajia Peng, Yue Wang, Qian Tang, Hailong Xie, Yazi Li, Xinghua Pan

Glutamine Regulates Cell Growth and Casein Synthesis through the CYTHs/ARFGAP1-Arf1-mTORC1 Pathway in Bovine Mammary Epithelial Cells

J Agric Food Chem.

doi: 10.1021/acs.jafc.1c02223.

1000. Lin Ding, Zhen-Jing Xu, Hao-Hao Shi, Chang-Hu Xue, Qing-Rong Huang, Teruyoshi Yanagita, Yu-Ming Wang, Tian-Tian Zhang

Sterol sulfate alleviates atherosclerosis via mediating hepatic cholesterol metabolism in ApoE-/- mice

Food Funct.

doi: 10.1039/d0fo03266b.

(IF 4.171)

1001. Qiuling Fu, Zuyun Wei, Yuhong Chen, Jingguang Xie, Xiangyang Zhang, Tianliang He, Xinhua Chen

Development of monoclonal antibody against IgT of a perciform fish, large yellow croaker (Larimichthys crocea) and characterization of IgT+ B cells

Dev Comp Immunol.

doi: 10.1016/j.dci.2021.104027.

(IF 3.192)

1002. Xingyu Ma, Xiaoli Li, Qianqian Di, Xibao Zhao, Ruihan Zhang, Yue Xiao, Ping Sun, Haimei Tang, Jiazheng Quan, Weilie Xiao, Weilin Chen

Natural molecule Munronoid I attenuates LPS-induced acute lung injury by promoting the K48-linked ubiquitination and degradation of TAK1

Biomed Pharmacother.

doi: 10.1016/j.biopha.2021.111543.

(IF 4.545)

1003. Qirong Lu, Siyi Hu, Pu Guo, Xiaohui Zhu, Zhongchang Ren, Qinghua Wu, Xu Wang

PPAR-γ with its anti-fibrotic action could serve as an effective therapeutic target in T-2 toxin-induced cardiac fibrosis of rats

Food Chem Toxicol.

doi: 10.1016/j.fct.2021.112183.

(IF 4.679)

1004. Jiapeng Hu, Jia Wang, Chunlu Li, Yunxiao Shang

Fructose-1,6-bisphosphatase aggravates oxidative stress-induced apoptosis in asthma by suppressing the Nrf2 pathway

J Cell Mol Med.

doi: 10.1111/jcmm.16439.

(IF 4.486)

1005. Jie Ren, Zhen Ding, Puxian Fang, Shaobo Xiao, Liurong Fang

ATPase and helicase activities of porcine epidemic diarrhea virus nsp13

Vet Microbiol.

doi: 10.1016/j.vetmic.2021.109074.

(IF 3.03)

1006. Yan-Long Tang, Xiao-Bo Wang, Yue Zhou, Ya-Ping Wang, Ji-Chao Ding

Ginsenoside Rg1 induces senescence of leukemic stem cells by upregulating p16INK4a and downregulating hTERT expression

Adv Clin Exp Med.

doi: 10.17219/acem/133485.

(IF 1.514)

1007. Xiunan Kong, Xiu Wang, Yumei Qin, Jianzhong Han

Effects of sunset yellow on proliferation and differentiation of intestinal epithelial cells in murine intestinal organoids

J Appl Toxicol.

doi: 10.1002/jat.4080.

(IF 2.997)

1008. Xiaohui Xu, Yong Wu, Ke Yi, Yan Hu, Weiqun Ding, Chungen Xing

IRF1 regulates the progression of colorectal cancer via interferon‑induced proteins

Int J Mol Med.

doi: 10.3892/ijmm.2021.4937.

(IF 3.098)

1009. Haiyan Xu, Dan Song, Renfang Xu, Xiaozhou He

BAFF signaling drives interstitial transformation of mouse renal tubular epithelial cells in a Pin1-dependent manner

In Vitro Cell Dev Biol Anim.

doi: 10.1007/s11626-021-00598-y.

1010. Hengxiao Lu, Hao Wang, Peidao Sun, Jiang Wang, Shuhai Li, Tongzhen Xu

MiR-522-3p inhibits proliferation and activation by regulating the expression of SLC31A1 in T cells

Cytotechnology.

doi: 10.1007/s10616-021-00472-5.

(IF 1.777)

1011. Haifeng Yu, Shuailing Peng, Shuiyun Han, Xi Chen, Qinghua Lyu, Tao Lei

Distinct Molecular Subtypes of Diffuse Large B Cell Lymphoma Patients Treated with Rituximab-CHOP Are Associated with Different Clinical Outcomes and Molecular Mechanisms

Biomed Res Int.

doi: 10.1155/2021/5514726.

(IF 2.276)

1012. Wenjing Ma, Yong Cai, Yuntian Shen, Xin Chen, Lilei Zhang, Yanan Ji, Zehao Chen, Jianwei Zhu, Xiaoming Yang, Hualin Sun

HDAC4 Knockdown Alleviates Denervation-Induced Muscle Atrophy by Inhibiting Myogenin-Dependent Atrogene Activation

Front Cell Neurosci.

doi: 10.3389/fncel.2021.663384.

(IF 3.921)

1013. Yuhua He, Jiaqi Chen, Qiyue Zhang, Jialong Zhang, Lulai Wang, Xiaoxia Chen, Adrian J Molenaar, Xuezhao Sun

α-Chaconine Affects the Apoptosis, Mechanical Barrier Function, and Antioxidant Ability of Mouse Small Intestinal Epithelial Cells

Front Plant Sci.

doi: 10.3389/fpls.2021.673774.

(IF 4.402)

1014. Xia Wang, Yansong Ge, Mingqi Shi, Hanhan Dai, Wei Liu, Peiyuan Wang

Protein kinase N1 promotes proliferation and invasion of liver cancer

Exp Ther Med.

doi: 10.3892/etm.2021.10083.

(IF 1.785)

1015. Xiaoli Liao, Yue Li, Zhenzhu Hu, Ying Lin, Bo Zheng, Jihua Ding

Poplar acetylome profiling reveals lysine acetylation dynamics in seasonal bud dormancy release

Plant Cell Environ.

doi: 10.1111/pce.14040.

(IF 6.362)

1016. Shuo Zhou, Yanfen Ma, Jinwei Yao, An Zhao, Chukang Xie, Yuling Mi, Caiqiao Zhang

TGF-β1-induced collagen promotes chicken ovarian follicle development via an intercellular cooperative pattern

Cell Biol Int.

doi: 10.1002/cbin.11580.

(IF 2.571)

1017. Zhuang Shen, Zhen Liu, Xin Rui, Xiaohong Chen, Mei Jiang, Mingsheng Dong

Effects of fat content on the textural and in vivo buccal breakdown properties of soy yogurt

J Texture Stud.

doi: 10.1111/jtxs.12584.

(IF 1.902)

1018. Tao Li, Yingchun Wan, Ziyuan Su, Jiayu Li, Minna Han, Changyu Zhou

Mesenchymal Stem Cell-Derived Exosomal microRNA-3940-5p Inhibits Colorectal Cancer Metastasis by Targeting Integrin α6

Dig Dis Sci.

doi: 10.1007/s10620-020-06458-1.

1019. Shanshan Jia, Pin Guo, Junhua Lu, Xujun Huang, Laming Deng, Yan Jin, Lanyan Zhao, Xiaofang Fan

Curcumol Ameliorates Lung Inflammation and Airway Remodeling via Inhibiting the Abnormal Activation of the Wnt/β-Catenin Pathway in Chronic Asthmatic Mice

Drug Des Devel Ther.

doi: 10.2147/DDDT.S292642.

1020. Wei Feng

Tectorigenin attenuates cognitive impairments in mice with chronic cerebral ischemia by inhibiting the TLR4/NF-κB signaling pathway

Biosci Biotechnol Biochem.

doi: 10.1093/bbb/zbab086.

1021. Hongyan Wang, Huaiqing Gao

Protective effects of repetitive transcranial magnetic stimulation against 6-OHDA-induced Parkinson's symptoms in a mice model: the key role of miR-409-3p/PDHB axis

Int J Neurosci.

doi: 10.1080/00207454.2021.1938037.

(IF 2.107)

1022. Huiying Pan, Yi Xu, Qian Cai, Meiling Wu, Mingxing Ding

Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism

Med Sci Monit.

doi: 10.12659/MSM.931884.

1023. Zupeng Luo, Hailong Hu, Siqi Liu, Zhiwang Zhang, Yixing Li, Lei Zhou

Comprehensive analysis of the translatome reveals the relationship between the translational and transcriptional control in high fat diet-induced liver steatosis

RNA Biol.

doi: 10.1080/15476286.2020.1827193.

(IF 5.35)

1024. Ying Liang, Wen-Yu Tian, Juan-Juan Huang, Ling-Xi Gao, Xiao-Hui Fan

MicroRNA-204 plays a role as a tumor suppressor in Newcastle disease virus-induced oncolysis in lung cancer A549 cells

Oncol Lett.

doi: 10.3892/ol.2021.12743.

(IF 2.311)

1025. Jinhui Dong, Ou Xu, Jianxing Wang, Chunguang Shan, Xiumin Ren

Luteolin ameliorates inflammation and Th1/Th2 imbalance via regulating the TLR4/NF-κB pathway in allergic rhinitis rats

Immunopharmacol Immunotoxicol.

doi: 10.1080/08923973.2021.1905659.

1026. Qian Chai, Jiajing Miao, Meili Liu, Ziying Zhang, Ziang Meng, Weihua Wu

Knockdown of SGLT1 prevents the apoptosis of cardiomyocytes induced by glucose fluctuation via relieving oxidative stress and mitochondrial dysfunction

Biochem Cell Biol.

doi: 10.1139/bcb-2020-0491.

(IF 2.46)

1027. Lichuang Zhang, Hao Xu, Ziyi Cheng, Yan Wei, Ruize Sun, Ziwei Liang, Yinchun Hu, Liqin Zhao, Xiaojie Lian, Xia Li, Di Huang

Human Cancer Cell Membrane-Cloaked Fe3O4 Nanocubes for Homologous Targeting Improvement

J Phys Chem B.

doi: 10.1021/acs.jpcb.1c04383.

(IF 2.857)

1028. Wei Guo, Shan Liu, Xinting Zheng, Zhiwei Xiao, Hanrui Chen, Lingling Sun, Chi Zhang, Zhijie Wang, Lizhu Lin

Network Pharmacology/Metabolomics-Based Validation of AMPK and PI3K/AKT Signaling Pathway as a Central Role of Shengqi Fuzheng Injection Regulation of Mitochondrial Dysfunction in Cancer-Related Fatig

Oxid Med Cell Longev.

doi: 10.1155/2021/5556212.

(IF 5.076)

1029. Bo Fu, Wei Liu, Cui Zhu, Peng Li, Li Wang, Li Pan, Ke Li, Peiying Cai, Min Meng, Yiting Wang, Anqi Zhang, Wenqiang Tang, Meng An

Circular RNA circBCBM1 promotes breast cancer brain metastasis by modulating miR-125a/BRD4 axis

Int J Biol Sci.

doi: 10.7150/ijbs.58916.

(IF 4.858)

1030. Lin Zhou, Jianing Li, Jinsong Liu, Anbei Wang, Ying Liu, Hao Yu, Hongsheng Ouyang, Daxin Pang

Investigation of the lncRNA THOR in Mice Highlights the Importance of Noncoding RNAs in Mammalian Male Reproduction

Biomedicines.

doi: 10.3390/biomedicines9080859.

1031. Wanzun Lin, Yun Sun, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J Lu

VMP1, a novel prognostic biomarker, contributes to glioma development by regulating autophagy

J Neuroinflammation.

doi: 10.1186/s12974-021-02213-z.

1032. Suqin Wang, Siyu Yang, Jun Zuo, Chenlin Hu, Lirong Song, Nanqin Gan, Peng Chen

Simultaneous Removal of the Freshwater Bloom-Forming Cyanobacterium Microcystis and Cyanotoxin Microcystins via Combined Use of Algicidal Bacterial Filtrate and the Microcystin-Degrading Enzymatic Age

Microorganisms.

doi: 10.3390/microorganisms9081594.

(IF 4.152)

1033. Xiaowei Cai, Yiheng Dai, Peng Gao, Guanyu Ren, Dingcai Cheng, Bo Wang, Yi Wang, Jiang Yu, Yiheng Du, Xizhi Wang, Boxin Xue

LncRNA CCAT1 promotes prostate cancer cells proliferation, migration, and invasion through regulation of miR-490-3p/FRAT1 axis

Aging (Albany NY).

doi: 10.18632/aging.203300.

1034. Xue Kong, Juan Li, Yanru Li, Weili Duan, Qiuchen Qi, Tiantian Wang, Qifeng Yang, Lutao Du, Haiting Mao, Chuanxin Wang

A novel long non-coding RNA AC073352.1 promotes metastasis and angiogenesis via interacting with YBX1 in breast cancer

Cell Death Dis.

doi: 10.1038/s41419-021-03943-x.

(IF 6.304)

1035. Jianping Wu, Qian Xie, Yanjun Liu, Yanan Gao, Zhipeng Qu, Lian Mo, Ying Xu, Ruihuan Chen, Liyun Shi

A Small Vimentin-Binding Molecule Blocks Cancer Exosome Release and Reduces Cancer Cell Mobility

Front Pharmacol.

doi: 10.3389/fphar.2021.627394.

(IF 4.225)

1036. Lihong Lu, Ziwen Zhong, Jiahui Gu, Ke Nan, Minmin Zhu, Changhong Miao

ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy

Mol Med.

doi: 10.1186/s10020-021-00339-7.

(IF 4.096)

1037. Tianyan Jiang, Haoxiang Guo, Ya-Nan Xia, Yun Liu, Dandan Chen, Guibin Pang, Yahui Feng, Huan Yu, Yanxian Wu, Shaodian Zhang, Yangyun Wang, Yong Wang, Hairuo Wen, Leshuai W Zhang

Hepatotoxicity of copper sulfide nanoparticles towards hepatocyte spheroids using a novel multi-concave agarose chip method

Nanomedicine (Lond).

doi: 10.2217/nnm-2021-0011.

1038. Mengyue Chen, Yugang Chi, Hongwei Chen, Limei Zhao

Long non-coding RNA USP30-AS1 aggravates the malignant progression of cervical cancer by sequestering microRNA-299-3p and thereby overexpressing PTP4A1

Oncol Lett.

doi: 10.3892/ol.2021.12766.

(IF 2.311)

1039. Wenzhao Wang, Bing Han, Jianan Chen, Huichao Tian, Mingjie Sun, Yunpeng Jiang, Wei Xie

Tolerogenic dendritic cells suppress titanium particle-induced inflammation

Exp Ther Med.

doi: 10.3892/etm.2021.10144.

(IF 1.785)

1040. Shuguang Han, Feng Zhu, Xiaoxia Huang, Panpan Yan, Ke Xu, Fangfang Shen, Jiawen Sun, Zeyu Yang, Guoxi Jin, Yiqun Teng

Maternal obesity accelerated non-alcoholic fatty liver disease in offspring mice by reducing autophagy

Exp Ther Med.

doi: 10.3892/etm.2021.10148.

(IF 1.785)

1041. Pengyu Jia, Nan Wu, Huimin Yang, Yuxuan Guo, Xiaofan Guo, Yingxian Sun

Different roles of BAG3 in cardiac physiological hypertrophy and pathological remodeling

Transl Res.

doi: 10.1016/j.trsl.2021.02.004.

(IF 5.411)

1042. Wenhui Dong, Qing Dong, Hairui Ding

Ophiopogonin B induces reactive oxygen species‑dependent apoptosis through the Hippo pathway in nasopharyngeal carcinoma

Mol Med Rep.

doi: 10.3892/mmr.2021.12173.

(IF 2.1)

1043. Weiping Wang, Jingyang Liu, Mingzhu Yang, Ruiqi Qiu, Ya Li, Shasha Bian, Bingtao Hao, Bo Lei

Intravitreal Injection of an Exosome-Associated Adeno-Associated Viral Vector Enhances Retinoschisin 1 Gene Transduction in the Mouse Retina

Hum Gene Ther.

doi: 10.1089/hum.2020.328.

(IF 4.273)

1044. Jie Wei, Yan Wang, Xiangming Qi, Yonggui Wu

Enhanced Bruton's tyrosine kinase activity in the kidney of patients with IgA nephropathy

Int Urol Nephrol.

doi: 10.1007/s11255-020-02733-2.

(IF 1.843)

1045. Zuotian Wu, Lin Zhou, Limin Sun, Yumeng Xie, Ling Xiao, Huiling Wang, Gaohua Wang

Brief postpartum separation from offspring promotes resilience to lipopolysaccharide challenge-induced anxiety and depressive-like behaviors and inhibits neuroinflammation in C57BL/6J dams

Brain Behav Immun.

doi: 10.1016/j.bbi.2021.03.016.

(IF 6.633)

1046. Liyuan Cui, Feng Xu, Songcun Wang, Zhuxuan Jiang, Lu Liu, Yan Ding, Xiaoli Sun, Meirong Du

Melatonin-MT1 signal is essential for endometrial decidualization

Reproduction.

doi: 10.1530/REP-21-0159.

(IF 3.206)

1047. Ke Zhang, Xingtao Zhou, Junqiao Wang, Yujia Zhou, Wucheng Qi, Haihong Chen, Shaoping Nie, Mingyong Xie

Dendrobium officinale polysaccharide triggers mitochondrial disorder to induce colon cancer cell death via ROS-AMPK-autophagy pathway

Carbohydr Polym.

doi: 10.1016/j.carbpol.2021.118018.

1048. Yueying Li, Zhan Zhang, Ke Xu, Shuang Du, Xiaosong Gu, Rangjuan Cao, Shusen Cui

Minocycline alleviates peripheral nerve adhesion by promoting regulatory macrophage polarization via the TAK1 and its downstream pathway

Life Sci.

doi: 10.1016/j.lfs.2021.119422.

(IF 3.647)

1049. Yiwei Wang, Xiaochen Xie, Shu Li, Dongyong Zhang, Heyu Zheng, Min Zhang, Zhong Zhang

Co-overexpression of RIOK1 and AKT1 as a prognostic risk factor in glioma

J Cancer.

doi: 10.7150/jca.60596.

(IF 3.565)

1050. Peipei Liu, Shengnan Yang, Zai Wang, Huaping Dai, Chen Wang

Feasibility and Mechanism Analysis of Shenfu Injection in the Treatment of Idiopathic Pulmonary Fibrosis

Front Pharmacol.

doi: 10.3389/fphar.2021.670146.

(IF 4.225)

1051. Lu Gan, Baosheng Huang, Zhaojian Song, Yachun Zhang, Yujie Zhang, Si Chen, Liqi Tong, Zhisong Wei, Lingxiang Yu, Xiangbo Luo, Xianhua Zhang, Detian Cai, Yuchi He

Unique Glutelin Expression Patterns and Seed Endosperm Structure Facilitate Glutelin Accumulation in Polyploid Rice Seed

Rice (N Y).

doi: 10.1186/s12284-021-00500-0.

1052. Xuemei Cao, Min Mao, Junlin Diao, Yi Hou, Hong Su, Yongjun Gan, Jibin Li, Xiaoyong Tong, Chaodong Wu, Zhong Zuo, Xiaoqiu Xiao

Ectopic Overexpression of PPARγ2 in the Heart Determines Differences in Hypertrophic Cardiomyopathy After Treatment With Different Thiazolidinediones in a Mouse Model of Diabetes

Front Pharmacol.

doi: 10.3389/fphar.2021.683156.

(IF 4.225)

1053. Limei Chen, He Chen, Yanli Xing, Juan Li

ABCC1 regulates cocaine-associated memory, spine plasticity and GluA1 and GluA2 surface expression

Neuroreport.

doi: 10.1097/WNR.0000000000001657.

(IF 1.394)

1054. Luying Cui, Yang Qu, Hele Cai, Heng Wang, Junsheng Dong, Jun Li, Chen Qian, Jianji Li

Meloxicam Inhibited the Proliferation of LPS-Stimulated Bovine Endometrial Epithelial Cells Through Wnt/β-Catenin and PI3K/AKT Pathways

Front Vet Sci.

doi: 10.3389/fvets.2021.637707.

(IF 2.245)

1055. Yaqun Wang, Xiaonan Sima, Ying Ying, Yonghong Huang

Exogenous BMP9 promotes lung fibroblast HFL-1 cell activation via ALK1/Smad1/5 signaling in vitro

Exp Ther Med.

doi: 10.3892/etm.2021.10160.

(IF 1.785)

1056. Yuan Yang, Chunyan Liu, Tingting Xie, Dapeng Wang, Xiong Chen, Lu Ma, Aihua Zhang

Role of inhibiting Chk1-p53 pathway in hepatotoxicity caused by chronic arsenic exposure from coal-burning

Hum Exp Toxicol.

doi: 10.1177/0960327120988880.

(IF 2.067)

1057. Bin Zhao, Tongyao Yu, Shenghang Wang, Jingmin Che, Liangfu Zhou, Peng Shang

Static Magnetic Field (0.2-0.4 T) Stimulates the Self-Renewal Ability of Osteosarcoma Stem Cells Through Autophagic Degradation of Ferritin

Bioelectromagnetics.

doi: 10.1002/bem.22352.

(IF 2.278)

1058. Jing Chu, Jinghai Gao, Jing Wang, Lingling Li, Guoqiang Chen, Jianhong Dang, Zhifeng Wang, Zhijun Jin, Xiaojun Liu

Mechanism of hydrogen on cervical cancer suppression revealed by high‑throughput RNA sequencing

Oncol Rep.

doi: 10.3892/or.2021.8092.

(IF 3.417)

1059. Yan Tang, Chunsheng Hu

NMU Is a Poor Prognostic Biomarker in Patients with Lung Adenocarcinoma

Dis Markers.

doi: 10.1155/2021/5031479.

(IF 2.738)

1060. Xudong Tang, Qiaoru Dong, Jun Li, Fang Li, Bozena B Michniak-Kohn, Denggao Zhao, Chi-Tang Ho, Qingrong Huang

Anti-Melanogenic Mechanism of Tetrahydrocurcumin and Enhancing Its Topical Delivery Efficacy Using a Lecithin-Based Nanoemulsion

Pharmaceutics.

doi: 10.3390/pharmaceutics13081185.

(IF 4.421)

1061. Yu Bai, Qiang Du, Le Zhang, Ling Li, Lei Tang, Wei Zhang, Runyu Du, Ping Li, Ling Li

Fasudil alleviated insulin resistance through promotion of proliferation, attenuation of cell apoptosis and inflammation and regulation of RhoA/Rho kinase/insulin/nuclear factor-κB signalling pathway

J Pharm Pharmacol.

doi: 10.1093/jpp/rgab033.

(IF 2.571)

1062. Jiqiang Hu, Xuan Wang, Xiaoyun Cui, Wu Kuang, Dong Li, Jing Wang

Quercetin prevents isoprenaline-induced myocardial fibrosis by promoting autophagy via regulating miR-223-3p/FOXO3

Cell Cycle.

doi: 10.1080/15384101.2021.1932029.

(IF 3.699)

1063. Na Luo, Shiqin Liu, Xin Li, Yu Hu, Kejing Zhang

Circular RNA circHIPK3 promotes breast cancer progression via sponging MiR-326

Cell Cycle.

doi: 10.1080/15384101.2021.1939476.

(IF 3.699)

1064. Gang Wang, Qikai Sun, Hai Zhu, Yihui Bi, Haixing Zhu, Aman Xu

The stabilization of yes-associated protein by TGFβ-activated kinase 1 regulates the self-renewal and oncogenesis of gastric cancer stem cells

J Cell Mol Med.

doi: 10.1111/jcmm.16660.

(IF 4.486)

1065. Gang Ma, Weijie Dai, Juan Zhang, Qianjun Li, Biao Gu, Yaqi Song, Xiaozhong Yang

ELK1‑mediated upregulation of lncRNA LBX2‑AS1 facilitates cell proliferation and invasion via regulating miR‑491‑5p/S100A11 axis in colorectal cancer

Int J Mol Med.

doi: 10.3892/ijmm.2021.4971.

(IF 3.098)

1066. Zhuo-Min Ling, Qian Wang, Yu Ma, Peng Xue, Yun Gu, Mao-Hong Cao, Zhong-Ya Wei

Astrocyte Pannexin 1 Suppresses LPS-Induced Inflammatory Responses to Protect Neuronal SH-SY5Y Cells

Front Cell Neurosci.

doi: 10.3389/fncel.2021.710820.

(IF 3.921)

1067. Cong Wang, Hao Chen, Shi-Tang Ma, Bin-Bin Mao, Yu Chen, Hao-Nan Xu, Hao Yu

A Network Pharmacology Approach for Exploring the Mechanisms of Panax notoginseng Saponins in Ischaemic Stroke

Evid Based Complement Alternat Med.

doi: 10.1155/2021/5582782.

1068. Wensi Wu, Xiaojun Zhang, Jiaxin Zhou, Hongmei Yang, Junjun Chen, Le Zhao, Junying Zhong, Wei-Jye Lin, Zhi Wang

Clemastine Ameliorates Perioperative Neurocognitive Disorder in Aged Mice Caused by Anesthesia and Surgery

Front Pharmacol.

doi: 10.3389/fphar.2021.738590.

(IF 4.225)

1069. Haiwei Bao, Ting Chen, Junyan Zhu, Haiyang Xie, Fen Chen

CEUS-Based Radiomics Can Show Changes in Protein Levels in Liver Metastases After Incomplete Thermal Ablation

Front Oncol.

doi: 10.3389/fonc.2021.694102.

(IF 4.848)

1070. Fang Geng, Yunxiao Xie, Yi Wang, Jinqiu Wang

Depolymerization of chicken egg yolk granules induced by high-intensity ultrasound

Food Chem.

doi: 10.1016/j.foodchem.2021.129580.

(IF 6.306)

1071. Yujuan Kang, Lin Wan, Qin Wang, Yanling Yin, Jiena Liu, Lei Liu, Hao Wu, Lei Zhang, Xin Zhang, Shouping Xu, Da Pang

Long noncoding RNA SNHG1 promotes TERT expression by sponging miR-18b-5p in breast cancer

Cell Biosci.

doi: 10.1186/s13578-021-00675-5.

(IF 5.026)

1072. Zhaoqi Yuan, Zhu Zhu, Fangxing Zhu, Feixue Ding, Yinmin Wang, Xiuxia Wang, Xusong Luo, Jun Yang, Fei Liu, Di Sun

Impact of human adipose tissue-derived stem cells on dermatofibrosarcoma protuberans cells in an indirect co-culture: an in vitro study

Stem Cell Res Ther.

doi: 10.1186/s13287-021-02512-5.

(IF 5.116)

1073. Xi Cheng, Lili Qian, Bo Wang, Minjia Tan, Jing Li

SPA: A Quantitation Strategy for MS Data in Patient-derived Xenograft Models

Genomics Proteomics Bioinformatics.

doi: 10.1016/j.gpb.2019.11.016.

1074. Yujie Zhao, Yuan Chen, Jiayi Wang, Xue Zhu, Ke Wang, Yue Li, Fanfan Zhou

Ginkgolide J protects human synovial cells SW982 via suppression of p38‑dependent production of pro‑inflammatory mediators

Mol Med Rep.

doi: 10.3892/mmr.2021.12194.

(IF 2.1)

1075. Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He

Tripterygium glycoside suppresses epithelial‑to‑mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mol Med Rep.

doi: 10.3892/mmr.2021.12231.

(IF 2.1)

1076. Xiyi Hu, Linglian Kong, Chuanpi Xiao, Qidong Zhu, Zhigang Song

The AMPK-mTOR signaling pathway is involved in regulation of food intake in the hypothalamus of stressed chickens

Comp Biochem Physiol A Mol Integr Physiol.

doi: 10.1016/j.cbpa.2021.110979.

1077. Chun Wang, Ling Hu, Shuang Guo, Qing Yao, Xiufen Liu, Bo Zhang, Xiangwen Meng, Xiaosong Yang

Phosphocreatine attenuates doxorubicin-induced cardiotoxicity by inhibiting oxidative stress and activating TAK1 to promote myocardial survival in vivo and in vitro

Toxicology.

doi: 10.1016/j.tox.2021.152881.

(IF 4.099)

1078. Yu Guo, Huan Zhu, Xiangchen Li, Caiyun Ma, Yanan Li, Tingting Sun, Yuanyuan Wang, Chunjing Wang, Weijun Guan, Changqing Liu

RepSox effectively promotes the induced differentiation of sheep fibroblasts into adipocytes via the inhibition of the TGF‑β1/Smad pathway

Int J Mol Med.

doi: 10.3892/ijmm.2021.4981.

(IF 3.098)

1079. Cong Cong, Xiaohong Yuan, Ying Hu, Wenjing Chen, Yong Wang, Lei Tao

Sinigrin attenuates angiotensin II‑induced kidney injury by inactivating nuclear factor‑κB and extracellular signal‑regulated kinase signaling in vivo and in vitro

Int J Mol Med.

doi: 10.3892/ijmm.2021.4994.

(IF 3.098)

1080. Yanyi Li, Qifan Hu, Weishuo Li, Shijing Liu, Kaiming Li, Xiaoyu Li, Junjie Du, Zexuan Yu, Cong Wang, Can Zhang

Simultaneous blockage of contextual TGF-β by cyto-pharmaceuticals to suppress breast cancer metastasis

J Control Release.

doi: 10.1016/j.jconrel.2021.06.012.

(IF 7.727)

1081. Gen Li, Tianquan Yang, Yanling Chen, Jianping Bao, Di Wu, Xiaohan Hu, Chenxi Feng, Lixiao Xu, Mei Li, Gang Li, Meifang Jin, Yunyun Xu, Rui Zhang, Guanghui Qian, Jian Pan

USP5 Sustains the Proliferation of Glioblastoma Through Stabilization of CyclinD1

Front Pharmacol.

doi: 10.3389/fphar.2021.720307.

(IF 4.225)

1082. Nani Wang, Pingcui Xu, Renjie Wu, Xuping Wang, Yongjun Wang, Dan Shou, Yan Zhang

Timosaponin BII improved osteoporosis caused by hyperglycemia through promoting autophagy of osteoblasts via suppressing the mTOR/NFκB signaling pathway

Free Radic Biol Med.

doi: 10.1016/j.freeradbiomed.2021.05.014.

1083. Xu-Ting Song, Jia-Nan Zhang, Duo-Wei Zhao, Yu-Fei Zhai, Qi Lu, Mei-Yu Qi, Ming-Hai Lu, Shou-Long Deng, Hong-Bing Han, Xiu-Qin Yang, Yu-Chang Yao

Molecular cloning, expression, and functional features of IGF1 splice variants in sheep

Endocr Connect.

doi: 10.1530/EC-21-0181.

(IF 2.592)

1084. Panpan Zheng, Jiyu Kang, Entong Xing, Bin Zheng, Xueyao Wang, Huacheng Zhou

Lung Inflation With Hydrogen During the Cold Ischemia Phase Alleviates Lung Ischemia-Reperfusion Injury by Inhibiting Pyroptosis in Rats

Front Physiol.

doi: 10.3389/fphys.2021.699344.

(IF 3.367)

1085. Xiaoming Ma, Qiang Zhang, Yongfu La, Donghai Fu, Hiu Jiang, Pengjia Bao, Xiaoyun Wu, Min Chu, Xian Guo, Ping Yan, Chunnian Liang

Differential Abundance of Brain Mitochondrial Proteins in Yak and Cattle: A Proteomics-Based Study

Front Vet Sci.

doi: 10.3389/fvets.2021.663031.

(IF 2.245)

1086. Jingwu Zhu, Jiang Tian, Chao Yang, Junpeng Chen, Lihuang Wu, Mengni Fan, Xiaojun Cai

L-Arg-Rich Amphiphilic Dendritic Peptide as a Versatile NO Donor for NO/Photodynamic Synergistic Treatment of Bacterial Infections and Promoting Wound Healing

Small.

doi: 10.1002/smll.202101495.

(IF 11.459)

1087. Lihong Zhang, Xiaozhen Zhao, Wei Wang

Disruption of anchoring junctions in the testes of experimental varicocele rats

Exp Ther Med.

doi: 10.3892/etm.2021.10319.

(IF 1.785)

1088. Xiaoqi Zeng, Shanshan Jiang, Simin Ruan, Zhaoze Guo, Jingyun Guo, Minfeng Liu, Changsheng Ye, Jianyu Dong

MAPK4 silencing together with a PARP1 inhibitor as a combination therapy in triple‑negative breast cancer cells

Mol Med Rep.

doi: 10.3892/mmr.2021.12187.

(IF 2.1)

1089. Erpeng Liu, Lei Lv, Yonghao Zhan, Yuan Ma, Jinjin Feng, Yulin He, Yibo Wen, Yanping Zhang, Qingsong Pu, Fengping Ji, Xinghuan Yang, Jian Guo Wen

METTL3/N6-methyladenosine/ miR-21-5p promotes obstructive renal fibrosis by regulating inflammation through SPRY1/ERK/NF-κB pathway activation

J Cell Mol Med.

doi: 10.1111/jcmm.16603.

(IF 4.486)

1090. Hongyan Ma, Ying Liu, Zhengtian Li, Lu Yu, Yang Gao, Xiangmei Ye, Baoyi Yang, Hulun Li, Jinghui Shi

Propofol Protects Against Hepatic Ischemia Reperfusion Injury via Inhibiting Bnip3-Mediated Oxidative Stress

Inflammation.

doi: 10.1007/s10753-021-01416-z.

(IF 3.212)

1091. Yajie Yang, Yan Hu, Yile Zhou, Tao Liang, Haihong Tang, Huihui Ju, Qiqing Shi, Hao Fang

Lys694Arg polymorphism leads to blunted responses to LPS by interfering TLR4 with recruitment of MyD88

Innate Immun.

doi: 10.1177/1753425920927479.

1092. Ding Liu, Wanzhe Zhang

Pioglitazone Attenuates Lupus Nephritis Symptoms in Mice by Modulating miR-21-5p/TIMP3 Axis: the Key Role of the Activation of Peroxisome Proliferator-Activated Receptor-γ

Inflammation.

doi: 10.1007/s10753-021-01426-x.

(IF 3.212)

1093. Zehao Wang, Lixia Wang, Boya Shi, Xiuli Sun, Yinrong Xie, Haonan Yang, Chengting Zi, Xuanjun Wang, Jun Sheng

Demethyleneberberine promotes apoptosis and suppresses TGF-β/Smads induced EMT in the colon cancer cells HCT-116

Cell Biochem Funct.

doi: 10.1002/cbf.3638.

(IF 2.632)

1094. Yan Jiang, Caifeng Zhang, Tingli Wang

bFGF ameliorates intestinal mucosal permeability and barrier function through tight junction proteins in burn injury rats

Burns.

doi: 10.1016/j.burns.2020.11.004.

(IF 2.066)

1095. Yujie Jia, Yu Tong, Lianqiu Min, Yanrong Li, Yan Cheng

Protective effects of oridonin against cerebral ischemia/reperfusion injury by inhibiting the NLRP3 inflammasome activation

Tissue Cell.

doi: 10.1016/j.tice.2021.101514.

(IF 1.837)

1096. Zhenkui Ren, Yumei Hu, Dongfen Guo, Zhizhong Guan, Ling Chen, Jun He, Wenfeng Yu

Increased miR‑187‑3p expression after cerebral ischemia/reperfusion induces apoptosis via initiation of endoplasmic reticulum stress

Neurosci Lett.

doi: 10.1016/j.neulet.2021.135947.

(IF 2.274)

1097. Yuchen Jing, Bai Gao, Zhiyang Han, Lifang Xia, Shijie Xin

The protective effect of HOXA5 on carotid atherosclerosis occurs by modulating the vascular smooth muscle cell phenotype

Mol Cell Endocrinol.

doi: 10.1016/j.mce.2021.111366.

(IF 3.871)

1098. Chengjun Hu, Yingli Yan, Fengjie Ji, Hanlin Zhou

Maternal Obesity Increases Oxidative Stress in Placenta and It Is Associated With Intestinal Microbiota

Front Cell Infect Microbiol.

doi: 10.3389/fcimb.2021.671347.

1099. Hong Ye, Ying Meng

Honokiol regulates endoplasmic reticulum stress by promoting the activation of the sirtuin 1-mediated protein kinase B pathway and ameliorates high glucose/high fat-induced dysfunction in human umbili

Endocr J.

doi: 10.1507/endocrj.EJ20-0747.

(IF 1.952)

1100. Jun He, Zhenkui Ren, Wansong Xia, Cao Zhou, Bin Bi, Wenfeng Yu, Li Zuo

Identification of key genes and crucial pathways for major depressive disorder using peripheral blood samples and chronic unpredictable mild stress rat models

PeerJ.

doi: 10.7717/peerj.11694.

(IF 2.379)

1101. Bin Yin, Ruirui Lian, Zhen Li, Yueyue Liu, Shifa Yang, Zhongli Huang, Zengcheng Zhao, Ying Li, Chuanxi Sun, Shuqian Lin, Renzhong Wan, Guiming Li

Tea Polyphenols Enhanced the Antioxidant Capacity and Induced Hsps to Relieve Heat Stress Injury

Oxid Med Cell Longev.

doi: 10.1155/2021/9615429.

(IF 5.076)

1102. Cong Yu, Bin Wu, Jinsong Jiang, Guangwei Yang, Chao Weng, Fei Cai

Overexpressed lncRNA ROR Promotes the Biological Characteristics of ox-LDL-Induced HUVECs via the let-7b-5p/HOXA1 Axis in Atherosclerosis

Front Cardiovasc Med.

doi: 10.3389/fcvm.2021.659769.

1103. Hanrui Wang, Siying Pei, Shuqing Fang, Song Jin, Shuhua Deng, Yanan Zhao, Yao Feng

Irisin restores high glucose-induced cell injury in vascular endothelial cells by activating Notch pathway via Notch receptor 1

Biosci Biotechnol Biochem.

doi: 10.1093/bbb/zbab137.

1104. Ying Xu, Yunxia Dong, Cong Wang, Qian Jiang, Haichao Chu, Yue Tian

Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation

Neurochem Int.

doi: 10.1016/j.neuint.2021.105078.

(IF 3.881)

1105. Fengtong Liu, Yali Liu, Yuqing Du, Youshan Li

MiRNA-130a promotes inflammation to accelerate atherosclerosis via the regulation of proliferator-activated receptor γ (PPARγ) expression

Anatol J Cardiol.

doi: 10.5152/AnatolJCardiol.2021.56721.

(IF 1.223)

1106. Xin Ouyang, Zhengjia Wang, Mei Luo, Maozhou Wang, Xing Liu, Jiaxin Chen, JianGuo Feng, Jing Jia, Xiaobin Wang

Ketamine ameliorates depressive-like behaviors in mice through increasing glucose uptake regulated by the ERK/GLUT3 signaling pathway

Sci Rep.

doi: 10.1038/s41598-021-97758-7.

1107. Jiaqi Chen, Qiaoya Pan, Yang Bai, Xuepeng Chen, Yi Zhou

Hydroxychloroquine Induces Apoptosis in Cholangiocarcinoma via Reactive Oxygen Species Accumulation Induced by Autophagy Inhibition

Front Mol Biosci.

doi: 10.3389/fmolb.2021.720370.

(IF 4.188)

1108. Yingmin Qu, Jing Wang, Pengyun Huang, Xiaohong Liu, Jianping Lu, Fu-Cheng Lin

PoRal2 Is Involved in Appressorium Formation and Virulence via Pmk1 MAPK Pathways in the Rice Blast Fungus Pyricularia oryzae

Front Plant Sci.

doi: 10.3389/fpls.2021.702368.

(IF 4.402)

1109. Xiao-Yue Ge, Tian-Tian Zhu, Mao-Zhong Yao, Hong Liu, Qian Wu, Jie Qiao, Wei-Fang Zhang, Chang-Ping Hu

MicroRNA-137 Inhibited Hypoxia-Induced Proliferation of Pulmonary Artery Smooth Muscle Cells by Targeting Calpain-2

Biomed Res Int.

doi: 10.1155/2021/2202888.

(IF 2.276)

1110. Lin Cai, Jian Chen, Jianglong Lu, Qun Li, Xianbin Chen, Linlin Zhang, Jinsen Wu, Weiming Zheng, Chengde Wang, Zhipeng Su

Tumor stem-like cells isolated from MMQ cells resist to dopamine agonist treatment

Mol Cell Endocrinol.

doi: 10.1016/j.mce.2021.111396.

(IF 3.871)

1111. Yulu Tu, Dazhi Chen, Tongtong Pan, Zhengkang Chen, Jie Xu, Lanling Jin, Lina Sheng, Xiaozhi Jin, Xiaodong Wang, Xiaolin Lan, Yuli Ge, Huiling Sun, Yongping Chen

Inhibition of miR-431-5p attenuated liver apoptosis through KLF15/p53 signal pathway in S100 induced autoimmune hepatitis mice

Life Sci.

doi: 10.1016/j.lfs.2021.119698.

(IF 3.647)

1112. Ru Zhang, Shiquan Tan, Bianling Zhang, Pengcheng Hu, Ling Li

Cerium-Promoted Ginsenosides Accumulation by Regulating Endogenous Methyl Jasmonate Biosynthesis in Hairy Roots of Panax ginseng

Molecules.

doi: 10.3390/molecules26185623.

(IF 3.267)

1113. Jing Sun, Wugui Chen, Songtao Li, Sizhen Yang, Ying Zhang, Xu Hu, Hao Qiu, Jigong Wu, Shangcheng Xu, Tongwei Chu

Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway

Front Pharmacol.

doi: 10.3389/fphar.2021.751845.

(IF 4.225)

1114. Jiali Yuan, Ping Li, Honghong Pan, Qi Xu, Tiantian Xu, Yan Li, Dong Wei, Yiqun Mo, Qunwei Zhang, Jingyu Chen, Chunhui Ni

miR-770-5p inhibits the activation of pulmonary fibroblasts and silica-induced pulmonary fibrosis through targeting TGFBR1

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2021.112372.

1115. Menglin Liu, Xia Wu, Yilong Cui, Pengli Liu, Bonan Xiao, Xuliang Zhang, Jian Zhang, Zhuo Sun, Miao Song, Bing Shao, Yanfei Li

Mitophagy and apoptosis mediated by ROS participate in AlCl3-induced MC3T3-E1 cell dysfunction

Food Chem Toxicol.

doi: 10.1016/j.fct.2021.112388.

(IF 4.679)

1116. Si-Qiang Zheng, Huan-Xin Chen, Xiao-Cheng Liu, Qin Yang, Guo-Wei He

Identification of variants of ISL1 gene promoter and cellular functions in isolated ventricular septal defects

Am J Physiol Cell Physiol.

doi: 10.1152/ajpcell.00167.2021.

1117. Mengjuan Shang, Jimeng Zhang, Meilun Shen, Zhichuan Sun, Peng Gao, Jing Li, Junlin Xing, Guozhen Guo

Bright light exposure induces dynamic changes of spatial memory in nocturnal rodents

Brain Res Bull.

doi: 10.1016/j.brainresbull.2021.06.019.

(IF 3.37)

1118. Xing Ge, Yong Zuo, Jinhong Xie, Xincheng Li, Yan Li, Anand Thirupathi, Peng Yu, Guofen Gao, Changhao Zhou, Yanzhong Chang, Zhenhua Shi

A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism

Aging (Albany NY).

doi: 10.18632/aging.203544.

1119. Yao Liu, Qiong Tang, Zhili Rao, Yang Fang, Xinni Jiang, Wenjun Liu, Fei Luan, Nan Zeng

Inhibition of herpes simplex virus 1 by cepharanthine via promoting cellular autophagy through up-regulation of STING/TBK1/P62 pathway

Antiviral Res.

doi: 10.1016/j.antiviral.2021.105143.

1120. Xiaolong Song, Junhong Kong, Jun Song, Renyou Pan, Lei Wang

Angelica sinensis Polysaccharide Alleviates Myocardial Fibrosis and Oxidative Stress in the Heart of Hypertensive Rats

Comput Math Methods Med.

doi: 10.1155/2021/6710006.

1121. Huifeng Wang, Qingjun Zhou, Luqin Wan, Menglong Guo, Chen Chen, Junfa Xue, Lingling Yang, Lixin Xie

Lipidomic analysis of meibomian glands from type-1 diabetes mouse model and preliminary studies of potential mechanism

Exp Eye Res.

doi: 10.1016/j.exer.2021.108710.

(IF 3.011)

1122. Zhao Hu, Fengtong Yuan, Yutan Guo, Suping Ying, Jie Chen, Danpeng Zhu, Lu Cai, Xiaowei Wang, Wei Liu, Xiaojue Peng

OsCBL1 affects rice seedling growth by modulating nitrate and phosphate responses

Gene.

doi: 10.1016/j.gene.2021.145806.

(IF 2.984)

1123. Yunlian Zou, Jinping Zhang, Lichen Zhang, Xinmin Yan

Interferon-induced protein 16 expression in colorectal cancer and its correlation with proliferation and immune signature markers

Oncol Lett.

doi: 10.3892/ol.2021.12948.

(IF 2.311)

1124. Dong-Lin Yang, Ya-Jun Zhang, Liu-Jun He, Chun-Sheng Hu, Li-Xia Gao, Jiu-Hong Huang, Yan Tang, Jie Luo, Dian-Yong Tang, Zhong-Zhu Chen

Demethylzeylasteral (T-96) initiates extrinsic apoptosis against prostate cancer cells by inducing ROS-mediated ER stress and suppressing autophagic flux

Biol Res.

doi: 10.1186/s40659-021-00350-6.

(IF 3.092)

1125. Jing-Yu Duan, Wei Chen, Yang-Qi Zhao, Liang-Liang He, En-Chao Li, Zhong-Hui Bai, Yong-Jian Wang, Chun-Ping Zhang

Flavonoids from Hypericum patulum enhance glucose consumption and attenuate lipid accumulation in HepG2 cells

J Food Biochem.

doi: 10.1111/jfbc.13898.

(IF 1.662)

1126. Min Fei, Zheng Li, Yuanwu Cao, Chang Jiang, Haodong Lin, Zixian Chen

MicroRNA-182 improves spinal cord injury in mice by modulating apoptosis and the inflammatory response via IKKβ/NF-κB

Lab Invest.

doi: 10.1038/s41374-021-00606-5.

(IF 4.197)

1127. Yu Feng, Xu Tian, Miao Zhang, Shujie Lou

Treadmill Exercise Reverses the Change of Dendritic Morphology and Activates BNDF-mTOR Signaling Pathway in the Hippocampus and Cerebral Cortex of Ovariectomized Mice

J Mol Neurosci.

doi: 10.1007/s12031-021-01848-0.

(IF 2.678)

1128. Yuanyuan Fang, Dongjie Peng, Yuan Liang, Lili Lu, Junyan Li, Lin Zhao, Shiyan Ou, Shaojun Li, Michael Aschner, Yueming Jiang

Sodium P-aminosalicylic Acid Inhibits Manganese-Induced Neuroinflammation in BV2 Microglial Cells via NLRP3-CASP1 Inflammasome Pathway

Biol Trace Elem Res.

doi: 10.1007/s12011-020-02471-7.

(IF 2.639)

1129. Zeyu Jiang, Jiang Shen, Jie Ding, Yan Yuan, Lulu Gao, Zhuocheng Yang, Xin Zhao

USP18 mitigates lipopolysaccharide-induced oxidative stress and inflammation in human pulmonary microvascular endothelial cells through the TLR4/NF-κB/ROS signaling

Toxicol In Vitro.

doi: 10.1016/j.tiv.2021.105181.

(IF 2.959)

1130. Xuezuo Sui, Yanchun Wang, Hui Liu

hsa_circ_0101119 facilitates the progression of cervical cancer via an interaction with EIF4A3 to inhibit TCEAL6 expression

Mol Med Rep.

doi: 10.3892/mmr.2021.12293.

(IF 2.1)

1131. Su-Su Tang, Shu-Yun Xing, Xue-Jiao Zhang, Xiao-Qian Ren, Hao Hong, Yan Long

Neuroprotective effects of novel compound Tozan on cognition, neurogenesis and apoptosis in diabetes

Ann Transl Med.

doi: 10.21037/atm-21-4439.

(IF 3.297)

1132. Jianxiu Duan, Mingyuan Yin, Yaqin Shao, Jiao Zheng, Shengdan Nie

Puerarin induces platinum-resistant epithelial ovarian cancer cell apoptosis by targeting SIRT1

J Int Med Res.

doi: 10.1177/03000605211040762.

(IF 1.287)

1133. Bang Wang, Xiujuan Lv, Yufei Wang, Zhibo Wang, Qi Liu, Bin Lu, Yong Liu, Feng Gu

CRISPR/Cas9-mediated mutagenesis at microhomologous regions of human mitochondrial genome

Sci China Life Sci.

doi: 10.1007/s11427-020-1819-8.

(IF 4.611)

1134. Zhujun Zhu, Sihong Wang, Qi Cao, Gang Li

CircUBQLN1 Promotes Proliferation but Inhibits Apoptosis and Oxidative Stress of Hippocampal Neurons in Epilepsy via the miR-155-Mediated SOX7 Upregulation

J Mol Neurosci.

doi: 10.1007/s12031-021-01838-2.

(IF 2.678)

1135. Qingwei Yang, Jingcong Zhuang, Pingping Cai, Longling Li, Rong Wang, Zhongjie Chen

JKAP relates to disease risk, severity, and Th1 and Th17 differentiation in Parkinson's disease

Ann Clin Transl Neurol.

doi: 10.1002/acn3.51420.

1136. Tengda Huang, Jingsu Yu, Zupeng Luo, Lin Yu, Siqi Liu, Peng Wang, Mengting Jia, Tian Wu, Weiwei Miao, Lei Zhou, Ziyi Song, Haojie Zhang, Yixing Li

Translatome analysis reveals the regulatory role of betaine in high fat diet (HFD)-induced hepatic steatosis

Biochem Biophys Res Commun.

doi: 10.1016/j.bbrc.2021.08.058.

1137. Tingting Jin, Lei Xu, Peipei Wang, Xiaobei Hu, Runyuan Zhang, Zhiqi Wu, Wenxin Du, Weijuan Kan, Kun Li, Chang Wang, Yubo Zhou, Jia Li, Tao Liu

Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile

J Med Chem.

doi: 10.1021/acs.jmedchem.1c00994.

(IF 6.205)

1138. Zeyu Xing, Menglu Zhang, Jiaqi Liu, Gang Liu, Kexin Feng, Xiang Wang

LINC00337 induces tumor development and chemoresistance to paclitaxel of breast cancer by recruiting M2 tumor-associated macrophages

Mol Immunol.

doi: 10.1016/j.molimm.2021.07.009.

(IF 3.641)

1139. Ting-Ting Gong, Qian Guo, Xiao Li, Tie-Ning Zhang, Fang-Hua Liu, Xin-Hui He, Bei Lin, Qi-Jun Wu

Isothiocyanate Iberin inhibits cell proliferation and induces cell apoptosis in the progression of ovarian cancer by mediating ROS accumulation and GPX1 expression

Biomed Pharmacother.

doi: 10.1016/j.biopha.2021.111533.

(IF 4.545)

1140. Lan Zhan, Xiangxiu Wang, Yanjing Zhang, Guonian Zhu, Yu Ding, Xuemei Chen, Wei Jiang, Sisi Wu

Benazepril hydrochloride protects against doxorubicin cardiotoxicity by regulating the PI3K/Akt pathway

Exp Ther Med.

doi: 10.3892/etm.2021.10516.

(IF 1.785)

1141. Jing Zhu, Ning Zhu, Jian Xu

miR‑101a‑3p overexpression prevents acetylcholine‑CaCl2‑induced atrial fibrillation in rats via reduction of atrial tissue fibrosis, involving inhibition of EZH2

Mol Med Rep.

doi: 10.3892/mmr.2021.12380.

(IF 2.1)

1142. Tingjiao Liu, Qianqian Li, Shanshan Yang, Tingting Zhao, Jinghan Lin, Ting Ju, Zhaohui Wen

CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway

Cell Biochem Funct.

doi: 10.1002/cbf.3662.

(IF 2.632)

1143. Zhibing Qiu, Wen Chen, Yafeng Liu, Ben Jiang, Li Yin, Xin Chen

LncRNA AC061961.2 overexpression inhibited endoplasmic reticulum stress induced apoptosis in dilated cardiomyopathy rats and cardiomyocytes via activating wnt/β-catenin pathway

J Recept Signal Transduct Res.

doi: 10.1080/10799893.2020.1828915.

1144. Shuo Li, Ruirong Guo, Zhibin Peng, Bingxuan Quan, Yuhang Hu, Yiwen Wang, Yansong Wang

NPR3, transcriptionally regulated by POU2F1, inhibits osteosarcoma cell growth through blocking the PI3K/AKT pathway

Cell Signal.

doi: 10.1016/j.cellsig.2021.110074.

(IF 3.968)

1145. Qian Sun, Yan-Chun Ji, Zheng-Li Wang, Xiang She, Yu He, Qing Ai, Lu-Quan Li

Sodium Butyrate Alleviates Intestinal Inflammation in Mice with Necrotizing Enterocolitis

Mediators Inflamm.

doi: 10.1155/2021/6259381.

1146. Jinglin Zhu, Ruifei Huang, Ruijie Yang, Yue Xiao, Jiangna Yan, Chunli Zheng, Wei Xiao, Chao Huang, Yonghua Wang

Licorice extract inhibits growth of non-small cell lung cancer by down-regulating CDK4-Cyclin D1 complex and increasing CD8+ T cell infiltration

Cancer Cell Int.

doi: 10.1186/s12935-021-02223-0.

(IF 4.175)

1147. Qian Ma, Jia Wang, Haopeng Yu, Junyi Sun, Jun Sun, Jiahao Chen, Yangyinhui Yu, Peihang Fang, Qi Tian, Junjun Ding

Protocol to alter a protein's phase separation capacity to control cell fate transitions

STAR Protoc.

doi: 10.1016/j.xpro.2021.100887.

1148. Heng Yin, Zhicai Zuo, Zhuangzhi Yang, Hongrui Guo, Jing Fang, Hengmin Cui, Ping Ouyang, Xia Chen, Jian Chen, Yi Geng, Zhengli Chen, Chao Huang, Yanqiu Zhu

Nickel induces autophagy via PI3K/AKT/mTOR and AMPK pathways in mouse kidney

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2021.112583.

1149. Qi Han, Honggui Liu, Runxiang Zhang, Xuesong Yang, Jun Bao, Houjuan Xing

Selenomethionine protects against ammonia-induced apoptosis through inhibition of endoplasmic reticulum stress in pig kidneys

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2021.112596.

1150. Rong-Hui Tu, Dong-Xiao Wang, Guo-Qiang Zhong, Jian-Jun Meng, Hong Wen, Jie-Feng, Qi Bi, Yan He

New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB

Open Med (Wars).

doi: 10.1515/med-2021-0340.

1151. Yuying Zhang, Anqi Guo, Cheng Lyu, Ran Bi, Zhaozhao Wu, Wenjing Li, Peng Zhao, Yudi Niu, Jie Na, Jianzhong Jeff Xi, Yanan Du

Synthetic liver fibrotic niche extracts achieve in vitro hepatoblasts phenotype enhancement and expansion

iScience.

doi: 10.1016/j.isci.2021.103303.

1152. Hongyan Ding, Yu Li, Leihong Liu, Ning Hao, Suping Zou, Qianming Jiang, Yusheng Liang, Nana Ma, Shibing Feng, Xichun Wang, Jinjie Wu, Juan J Loor

Sirtuin 1 is involved in oleic acid-induced calf hepatocyte steatosis via alterations in lipid metabolism-related proteins

J Anim Sci.

doi: 10.1093/jas/skab250.

(IF 2.092)

1153. Yunyi Bian, Qihai Sui, Guoshu Bi, Yuansheng Zheng, Mengnan Zhao, Guangyu Yao, Liang Xue, Yi Zhang, Hong Fan

Identification and Validation of a Proliferation-Associated Score Model Predicting Survival in Lung Adenocarcinomas

Dis Markers.

doi: 10.1155/2021/3219594.

(IF 2.738)

1154. Fan Feng, Lianhong Pan, Jiaqin Wu, Lanqing Li, Haiying Xu, Li Yang, Kang Xu, Chunli Wang

Cepharanthine inhibits hepatocellular carcinoma cell growth and proliferation by regulating amino acid metabolism and suppresses tumorigenesis in vivo

Int J Biol Sci.

doi: 10.7150/ijbs.64675.

(IF 4.858)

1155. Hao Zhang, Peng Xia, Jie Liu, Zhang Chen, Weijie Ma, Yufeng Yuan

ATIC inhibits autophagy in hepatocellular cancer through the AKT/FOXO3 pathway and serves as a prognostic signature for modeling patient survival

Int J Biol Sci.

doi: 10.7150/ijbs.65669.

(IF 4.858)

1156. Xianbao Huang, Ling Qi, Wei Lu, Ziye Li, Wuping Li, Fei Li

MYCN contributes to the sensitization of acute myelogenous leukemia cells to cisplatin by targeting SRY-box transcription factor 4

Bioengineered.

doi: 10.1080/21655979.2021.1997697.

(IF 2.205)

1157. Yu Xiang, Xiaying Chen, Wengang Wang, Lijuan Zhai, Xueni Sun, Jiao Feng, Ting Duan, Mingming Zhang, Ting Pan, Lili Yan, Ting Jin, Quan Gao, Chengyong Wen, Weirui Ma, Wencheng Liu, Deqiang Wang, Qibiao Wu, Tian Xie, Xinbing Sui

Natural Product Erianin Inhibits Bladder Cancer Cell Growth by Inducing Ferroptosis via NRF2 Inactivation

Front Pharmacol.

doi: 10.3389/fphar.2021.775506.

(IF 4.225)

1158. Hui Wang, Fei Shang, Jiawei Shen, Jingyi Xu, Xiaolin Chen, Jingtian Ni, Lumin Yu, Ting Xue

LsrR, the effector of AI-2 quorum sensing, is vital for the H2O2 stress response in mammary pathogenic Escherichia coli

Vet Res.

doi: 10.1186/s13567-021-00998-8.

(IF 3.357)

1159. Qianxing Zou, Lele Yang, Ruona Shi, Yuling Qi, Xiaofei Zhang, Huayu Qi

Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis

iScience.

doi: 10.1016/j.isci.2021.103396.

1160. Liyuan Cui, Feng Xu, Zhuxuan Jiang, Songcun Wang, Xinyi Li, Yan Ding, Ying Zhang, Meirong Du

Melatonin regulates proliferation and apoptosis of endometrial stromal cells via MT1

Acta Biochim Biophys Sin (Shanghai).

doi: 10.1093/abbs/gmab108.

1161. Lihong Lu, Xue Li, Ziwen Zhong, Wenchang Zhou, Di Zhou, Minmin Zhu, Changhong Miao

KMT5A downregulation participated in High Glucose-mediated EndMT via Upregulation of ENO1 Expression in Diabetic Nephropathy

Int J Biol Sci.

doi: 10.7150/ijbs.62867.

(IF 4.858)

1162. Jiaqi Xing, Xu Peng, Anqi Li, Meilin Chen, Yuan Ding, Xinyuan Xu, Peng Yu, Jing Xie, Jianshu Li

Gellan gum/alginate-based Ca-enriched acellular bilayer hydrogel with robust interface bonding for effective osteochondral repair

Carbohydr Polym.

doi: 10.1016/j.carbpol.2021.118382.

1163. Qi Han, Huiling Chen, Likai Wang, Yang An, Xiaoxiang Hu, Yaofeng Zhao, Hao Zhang, Ran Zhang

Systemic Deficiency of GHR in Pigs leads to Hepatic Steatosis via Negative Regulation of AHR Signaling

Int J Biol Sci.

doi: 10.7150/ijbs.64894.

(IF 4.858)

1164. Cai-Xia Yang, Lu Chen, Yu-Wei Yang, Qiao Mou, Zhi-Qiang Du

Acute heat stress reduces viability but increases lactate secretion of porcine immature Sertoli cells through transcriptome reprogramming

Theriogenology.

doi: 10.1016/j.theriogenology.2021.06.024.

(IF 2.094)

1165. Huijie Wu, Jingyuan Zhou, Songda Chen, Lingyu Zhu, Mengjie Jiang, Aiqun Liu

Survival-Related lncRNA Landscape Analysis Identifies LINC01614 as an Oncogenic lncRNA in Gastric Cancer

Front Genet.

doi: 10.3389/fgene.2021.698947.

(IF 3.258)

1166. Wen-Jing Guo, Yi-Cheng Wang, Yong-Dan Ma, Zhi-Hui Cui, Li-Xue Zhang, Li Nie, Xue-Qin Zhang, Mei-Jiao Wang, Jin-Hu Zhang, Dong-Zhi Yuan, Li-Min Yue

Contribution of high-fat diet-induced PCSK9 upregulation to a mouse model of PCOS is mediated partly by SREBP2

Reproduction.

doi: 10.1530/REP-21-0164.

(IF 3.206)

1167. Liang Sun, Yingyu Chen, Ping Yi, Li Yang, Yu Yan, Kailun Zhang, Qiaoying Zeng, Aizhen Guo

Serological detection of Mycobacterium Tuberculosis complex infection in multiple hosts by One Universal ELISA

PLoS One.

doi: 10.1371/journal.pone.0257920.

(IF 2.74)

1168. Yan-Bo Kou, Xiao-Qing Yan, Qi-Yue Jing, Sheng-Han Zhang, Zhuan-Zhuan Liu, Yan-Xia Wei, Yu-Gang Wang

LIGHT (TNFSF14) inhibits glucose uptake of adipocytes by downregulating GLUT4 expression via AKT signaling pathway

Biochem Biophys Res Commun.

doi: 10.1016/j.bbrc.2021.10.061.

1169. Panghua Ding, Jiajing Liu, Qiuyi Li, Qiongqiong Lu, Junxiang Li, Rui Shi, Lei Shi, Tangyou Mao, Dongyu Ge, HaiJun Niu, Guiying Peng, Zhibin Wang

Investigation of the Active Ingredients and Mechanism of Hudi Enteric-Coated Capsules in DSS-Induced Ulcerative Colitis Mice Based on Network Pharmacology and Experimental Verification

Drug Des Devel Ther.

doi: 10.2147/DDDT.S326029.

1170. Xiangli Xue, Feng Li, Ming Cai, Jingyun Hu, Qian Wang, Shujie Lou

Interactions between Endoplasmic Reticulum Stress and Autophagy: Implications for Apoptosis and Neuroplasticity-Related Proteins in Palmitic Acid-Treated Prefrontal Cells

Neural Plast.

doi: 10.1155/2021/8851327.

(IF 3.093)

1171. Wei Tian, Yinping Sun, Yuping Cheng, Xiao Ma, Weina Du, Wenna Shi, Qisen Guo

Arsenic sulfide reverses cisplatin resistance in non-small cell lung cancer in vitro and in vivo through targeting PD-L1

Thorac Cancer.

doi: 10.1111/1759-7714.14136.

(IF 2.61)

1172. Weiwei Liu, Liqiang Shi, Qiang Wan, Yansheng Wu, Di Huang, Jiaoying Ou, Qiuyu Liu, Xin Guan, Yuzhu Yang, Xiaotian Zhang, Jiandong Gao

Huangqi Guizhi Wuwu Decoction attenuates Podocyte cytoskeletal protein damage in IgA nephropathy rats by regulating AT1R/Nephrin/c-Abl pathway

Biomed Pharmacother.

doi: 10.1016/j.biopha.2021.111907.

(IF 4.545)

1173. Qianxing Zou, Huayu Qi

Deletion of ribosomal paralogs Rpl39 and Rpl39l compromises cell proliferation via protein synthesis and mitochondrial activity

Int J Biochem Cell Biol.

doi: 10.1016/j.biocel.2021.106070.

1174. Zihao Zhang, Xinyu Zhang, Chengwei Wang, Peng Zhou, Jie Xiao, Hui Zheng, Lei Wang, Senbo Yan, Yue Zhang, Xiaoping Ji

Deacetylated Sp1 improves β-glycerophosphate-induced calcification in vascular smooth muscle cells

Exp Ther Med.

doi: 10.3892/etm.2021.10586.

(IF 1.785)

1175. Dan Li, Wenjia Lai, Qingsong Wang, Zhichu Xiang, Xiaohui Nan, Xiaoliang Yang, Qiaojun Fang

CD151 enrichment in exosomes of luminal androgen receptor breast cancer cell line contributes to cell invasion

Biochimie.

doi: 10.1016/j.biochi.2021.06.007.

(IF 3.413)

1176. Di Zhao, Bo Yang, Chen Ye, Shaoyi Zhang, Xiaoqiong Lv, Qiyi Chen

Enteral nutrition ameliorates the symptoms of Crohn's disease in mice via activating special pro-resolving mediators through innate lymphoid cells

Innate Immun.

doi: 10.1177/17534259211057038.

1177. Zhijun Jiang, Zemeng Zhu, Mingyue Zhao, Wei Wang, Haonan Li, Dexiang Liu, Fang Pan

H3K9me2 regulation of BDNF expression in the hippocampus and medial prefrontal cortex is involved in the depressive-like phenotype induced by maternal separation in male rats

Psychopharmacology (Berl).

doi: 10.1007/s00213-021-05896-7.

1178. Yahan Zhang, Qiushi Gao, Ziyi Wu, Hang Xue, Ping Zhao

Sevoflurane Postconditioning Ameliorates Neuronal Migration Disorder Through Reelin/Dab1 and Improves Long-term Cognition in Neonatal Rats After Hypoxic-Ischemic Injury

Neurotox Res.

doi: 10.1007/s12640-021-00377-3.

(IF 2.992)

1179. Zhengrong Mei, Ye Hong, Haiyi Yang, Qiongyu Sheng, Bing Situ

Huperzine A protects against traumatic brain injury through anti-oxidative effects via the Nrf2-ARE pathway

Iran J Basic Med Sci.

doi: 10.22038/IJBMS.2021.58169.12932.

(IF 2.146)

1180. Zetian Shen, Li Yin, Han Zhou, Xiaoqin Ji, Changchen Jiang, Xixu Zhu, Xia He

Combined inhibition of AURKA and HSF1 suppresses proliferation and promotes apoptosis in hepatocellular carcinoma by activating endoplasmic reticulum stress

Cell Oncol (Dordr).

doi: 10.1007/s13402-021-00617-w.

1181. Xu Fan, Xiaoming Yin, Qi Zhao, Yi Yang

Hsa_circRNA_0045861 promotes renal injury in ureteropelvic junction obstruction via the microRNA-181d-5p/sirtuin 1 signaling axis

Ann Transl Med.

doi: 10.21037/atm-21-5060.

(IF 3.297)

1182. Xiaoyang Hua, Heng Chu, Chuanxiao Wang, Xuexin Shi, Ailin Wang, Zhe Zhang

Targeting USP22 with miR‑30‑5p to inhibit the hypoxia‑induced expression of PD‑L1 in lung adenocarcinoma cells

Oncol Rep.

doi: 10.3892/or.2021.8166.

(IF 3.417)

1183. Wenjuan Xun, Qingyao Fu, Liguang Shi, Ting Cao, Hongzheng Jiang, Zhonghua Ma

Resveratrol protects intestinal integrity, alleviates intestinal inflammation and oxidative stress by modulating AhR/Nrf2 pathways in weaned piglets challenged with diquat

Int Immunopharmacol.

doi: 10.1016/j.intimp.2021.107989.

(IF 3.943)

1184. Boning Cheng, Jianhong Jin, Dianlei Liu, Tingting Shi, Xiaoqing Fu, Chuntao Liu, Shourong Liu, Rui Wu

Oridonin interferes with simple steatosis of liver cells by regulating autophagy

Tissue Cell.

doi: 10.1016/j.tice.2021.101532.

(IF 1.837)

1185. Rongjiao Shao, Xintao Wang, Tianhua Xu, Yiyang Xia, Derong Cui

The balance between AIM2-associated inflammation and autophagy: the role of CHMP2A in brain injury after cardiac arrest

J Neuroinflammation.

doi: 10.1186/s12974-021-02307-8.

1186. Ran Liang, Qi Zhao, Qing Zhu, Xin He, Mingjun Gao, Yiru Wang

Lycium barbarum polysaccharide protects ARPE‑19 cells against H2O2‑induced oxidative stress via the Nrf2/HO‑1 pathway

Mol Med Rep.

doi: 10.3892/mmr.2021.12409.

(IF 2.1)

1187. Sheng-Lin Wang, Dan-Feng Weng, Hong-Xiang Wei, Zhen Huang, Ren-Qin Lin, Kai Shi, Jian-Hua Lin

Prognostic role of the recepteur d'origine nantais (RON) expression in primary high-grade osteosarcoma

J Orthop Sci.

doi: 10.1016/j.jos.2020.08.013.

(IF 1.259)

1188. Wuyang He, Yinghong Tang, Chunqiu Li, Xiaoyue Zhang, Shunping Huang, Benxu Tan, Zhenzhou Yang

Exercise Enhanced Cardiac Function in Mice With Radiation-Induced Heart Disease via the FNDC5/Irisin-Dependent Mitochondrial Turnover Pathway

Front Physiol.

doi: 10.3389/fphys.2021.739485.

(IF 3.367)

1189. Yang Zhang, Weifang Liu, Yanqi Zhong, Qi Li, Mengying Wu, Liu Yang, Xiaoxia Liu, Li Zou

Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF- κ B/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of P

Oxid Med Cell Longev.

doi: 10.1155/2021/1806344.

(IF 5.076)

1190. Xingyi Zhao, Minpeng Ji, Xin Wen, Dan Chen, Fu Huang, Xiaoju Guan, Jing Tian, Jiajia Xie, Jingjing Shao, Jiexia Wang, Luoqi Huang, Han Lin, Leping Ye, Haolin Chen

Effects of Midazolam on the Development of Adult Leydig Cells From Stem Cells In Vitro

Front Endocrinol (Lausanne).

doi: 10.3389/fendo.2021.765251.

1191. Jing He, Zhuang Wang, Yanbo Zhao, Jin Yang, Yuanxing Zhang, Qin Liu, Dahai Yang

Feeding with poly(I:C) induced long-term immune responses against bacterial infection in turbot ( Scophthalmus maximus)

Fish Shellfish Immunol Rep.

doi: 10.1016/j.fsirep.2021.100037.

1192. Yuan Wang, Yutong Sui, Aobo Lian, Xing Han, Feilin Liu, Kuiyang Zuo, Mingsheng Liu, Wei Sun, Ziyu Wang, Zinan Liu, Fei Zou, Rifeng Lu, Minghua Jin, Haiying Du, Kan Xu, Xiaomei Liu, Jinyu Liu

PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair

Front Cell Dev Biol.

doi: 10.3389/fcell.2021.739868.

(IF 5.201)

1193. Qing Tian, Chen Cao, Weijian Qiu, Han Wu, Lijun Zhou, Zhipeng Dai, Zhenwei Li, Songfeng Chen

RIPK1 Coordinates Bone Marrow Mesenchymal Stem Cell Survival by Maintaining Mitochondrial Homeostasis via p53

Stem Cells Int.

doi: 10.1155/2021/5540149.

(IF 3.869)

1194. Yilong Cui, Miao Song, Bonan Xiao, Menglin Liu, Pengli Liu, Yanfei Han, Bing Shao, Yanfei Li

ROS-mediated mitophagy and apoptosis are involved in aluminum-induced femoral impairment in mice

Chem Biol Interact.

doi: 10.1016/j.cbi.2021.109663.

1195. Zhongjuan Xu, Junjun Cao, Zhe Zhao, Yong Qiao, Xingzhi Liu, Junjie Zhong, Bin Wang, Guangli Suo

A functional extracellular matrix biomaterial enriched with VEGFA and bFGF as vehicle of human umbilical cord mesenchymal stem cells in skin wound healing

Biomed Mater.

doi: 10.1088/1748-605X/ac37b0.

(IF 3.174)

1196. Bingyu Li, Chaofan Hou, Xian Ju, Yong Feng, Zhi-Qiang Ye, Yunzhu Xiao, Mingyao Gu, Chunxiang Fu, Chaoliang Wei, Conghui You

Gain of Spontaneous clpX Mutations Boosting Motility via Adaption to Environments in Escherichia coli

Front Bioeng Biotechnol.

doi: 10.3389/fbioe.2021.772397.

1197. Ye-Hui Liao, Mo-Xian Chen, Shao-Chun Chen, Kai-Xuan Luo, Bin Wang, Yao Liu, Li-Juan Ao

Effects of Noninvasive Low-Intensity Focus Ultrasound Neuromodulation on Spinal Cord Neurocircuits In Vivo

Evid Based Complement Alternat Med.

doi: 10.1155/2021/8534466.

1198. Zhipeng Yan, Ni Zeng, Jieting Li, Tao Liao, Guoxin Ni

Cardiac Effects of Treadmill Running at Different Intensities in a Rat Model

Front Physiol.

doi: 10.3389/fphys.2021.774681.

(IF 3.367)

1199. Hongrui Guo, Heng Yin, Zhicai Zuo, Zhuangzhi Yang, Yue Yang, Ling Wei, Hengmin Cui, Huidan Deng, Xia Chen, Jian Chen, Yanqiu Zhu, Ping Ouyang, Yi Geng, Zongjun Du, Huaqiao Tang, Fengyuan Wang, Jing Fang

Oxidative stress-mediated apoptosis and autophagy involved in Ni-induced nephrotoxicity in the mice

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2021.112954.

1200. Na Sun, Lina Yu, Yibo Gao, Longfei Ma, Jinxuan Ren, Ying Liu, Dave Schwinn Gao, Chen Xie, Ying Wu, Lieju Wang, Juncong Hong, Min Yan

MeCP2 Epigenetic Silencing of Oprm1 Gene in Primary Sensory Neurons Under Neuropathic Pain Conditions

Front Neurosci.

doi: 10.3389/fnins.2021.743207.

1201. Xueyang Jiang, Chang Liu, Manxing Zou, Huanfang Xie, Tailiang Lin, Weiping Lyu, Jian Xu, Yuan Li, Feng Feng, Haopeng Sun, Wenyuan Liu

Discovery of 2-(cyclopropanecarboxamido)-N-(5-((1-(4-fluorobenzyl)piperidin-4-yl)methoxy)pyridin-3-yl)isonicotinamide as a potent dual AChE/GSK3β inhibitor for the treatment of Alzheimer's disease: Si

Eur J Med Chem.

doi: 10.1016/j.ejmech.2021.113663.

(IF 5.572)

1202. Liping Zhang, Yilin Liu, Sanrong Wang, Lu Long, Qianwen Zang, Jingxi Ma, Lehua Yu, Gongwei Jia

Vagus nerve stimulation mediates microglia M1/2 polarization via inhibition of TLR4 pathway after ischemic stroke

Biochem Biophys Res Commun.

doi: 10.1016/j.bbrc.2021.09.004.

1203. Yanyu Li, Guomei Su, Yu Zhong, Zhilin Xiong, Tong Huang, Jingyun Quan, Jiewen Huang, Xiaoxia Wen, Chaole Luo, Weilin Zheng, Jinfeng Chen, Junfen Cheng, Weimin Yao, Tianwen Lai

HB-EGF-induced IL-8 secretion from airway epithelium leads to lung fibroblast proliferation and migration

BMC Pulm Med.

doi: 10.1186/s12890-021-01726-w.

(IF 2.813)

1204. Yi Wang, Shengwen Wang, Weiwei Zhang, Jiayi Liu, Zhuo Yang, Chunhua Liu

Notch1 participates in the activation of autophagy in the hippocampus of type I diabetic mice

Neurochem Int.

doi: 10.1016/j.neuint.2021.105156.

(IF 3.881)

1205. Jian Luo, Qiang He, Jin-Zhi Xu, Chen Xu, Yin-Ze Han, Hai-Long Gao, Xian-Zhi Meng, Guo-Qing Pan, Tian Li, Ze-Yang Zhou

Microsporidia infection upregulates host energy metabolism but maintains ATP homeostasis

J Invertebr Pathol.

doi: 10.1016/j.jip.2021.107596.

(IF 2.074)

1206. Suna Zheng, Tianchi Zhuang, Yajun Tang, Ruihan Wu, Ting Xu, Tian Leng, Yao Wang, Zheng Lin, Minghui Ji

Leonurine protects against ulcerative colitis by alleviating inflammation and modulating intestinal microflora in mouse models

Exp Ther Med.

doi: 10.3892/etm.2021.10633.

(IF 1.785)

1207. Xinlu Li, Geng Lin, Tongtong Liu, Ning Zhao, He Xu, Huaqin Wang, Wei Zheng

Postnatal development of BAG3 expression in mouse cerebral cortex and hippocampus

Brain Struct Funct.

doi: 10.1007/s00429-021-02356-y.

(IF 3.298)

1208. Xueling Guo, Yan Deng, Linghui Zhan, Jin Shang, Huiguo Liu

O‑GlcNAcylation contributes to intermittent hypoxia‑associated vascular dysfunction via modulation of MAPKs but not CaMKII pathways

Mol Med Rep.

doi: 10.3892/mmr.2021.12384.

(IF 2.1)

1209. Chaohua Lv, Qingsong Wan, Chengxiang Shen, Hongsheng Wu, Bin Zhou, Weiwei Wang

Long non‑coding RNA ZSCAN16‑AS1 promotes the malignant properties of hepatocellular carcinoma by decoying microRNA‑451a and consequently increasing ATF2 expression

Mol Med Rep.

doi: 10.3892/mmr.2021.12420.

(IF 2.1)

1210. Weidang Xie, Wei Huang, Shumin Cai, Hui Chen, Weijun Fu, Zhongqing Chen, Yanan Liu

NF‑κB/IκBα signaling pathways are essential for resistance to heat stress‑induced ROS production in pulmonary microvascular endothelial cells

Mol Med Rep.

doi: 10.3892/mmr.2021.12454.

(IF 2.1)

1211. Pengli Liu, Yilong Cui, Menglin Liu, Bonan Xiao, Jian Zhang, Wanyue Huang, Xuliang Zhang, Miao Song, Yanfei Li

Protective effect of mitophagy against aluminum-induced MC3T3-E1 cells dysfunction

Chemosphere.

doi: 10.1016/j.chemosphere.2021.131086.

(IF 5.778)

1212. Juanjuan Qiu, Li Xu, Xiaohong Zeng, Zhenru Wu, Yu Wang, Yao Wang, Jiqiao Yang, Hao Wu, Yanyan Xie, Faqing Liang, Qing Lv, Zhenggui Du

NUSAP1 promotes the metastasis of breast cancer cells via the AMPK/PPARγ signaling pathway

Ann Transl Med.

doi: 10.21037/atm-21-5517.

(IF 3.297)

1213. Lingdi Nie, Liwen Jiang, John P Quinn, Blair D Grubb, Minyan Wang

TRPA1-Mediated Src Family Kinases Activity Facilitates Cortical Spreading Depression Susceptibility and Trigeminovascular System Sensitization

Int J Mol Sci.

doi: 10.3390/ijms222212273.

(IF 4.556)

1214. Nan Gao, Xiujing Dou, Ting Yin, Yang Yang, Di Yan, Ziwen Ma, Chongpeng Bi, Anshan Shan

Tryptophan Promotes Intestinal Immune Defense through Calcium-Sensing Receptor (CaSR)-Dependent Metabolic Pathways

J Agric Food Chem.

doi: 10.1021/acs.jafc.1c05820.

1215. Qi Shao, Junjie Huang, Jingui Li

Intracellular Replication Inhibitory Effects of Tea Tree Oil on Vesicular Stomatitis Virus and Anti-inflammatory Activities in Vero Cells

Front Vet Sci.

doi: 10.3389/fvets.2021.759812.

(IF 2.245)

1216. Tianhan Li, Juhui Qiu, Tingting Jia, Yinming Liang, Kun Zhang, Wenhua Yan, Zhengjun Hou, Shiwei Yang, Lushan Liu, Wenhao Xiong, Yaokai Chen, Guixue Wang

G3BP2 regulates oscillatory shear stress-induced endothelial dysfunction

Genes Dis.

doi: 10.1016/j.gendis.2021.11.003.

1217. Yan Huang, Yanping Dai, Min Li, Lulu Guo, Chulin Cao, Yuting Huang, Rui Ma, Shengyue Qiu, Xiaoyi Su, Kai Zhong, Yina Huang, Hong Gao, Qian Bu

Exposure to cadmium induces neuroinflammation and impairs ciliogenesis in hESC-derived 3D cerebral organoids

Sci Total Environ.

doi: 10.1016/j.scitotenv.2021.149043.

(IF 6.551)

1218. Zi Lv, Li-Ling Xiong, Xian Qin, Hua Zhang, Xin Luo, Wei Peng, Mark D Kilby, Richard Saffery, Philip N Baker, Hong-Bo Qi

Role of GRK2 in Trophoblast Necroptosis and Spiral Artery Remodeling: Implications for Preeclampsia Pathogenesis

Front Cell Dev Biol.

doi: 10.3389/fcell.2021.694261.

(IF 5.201)

1219. Xunxun Wu, Lian Liu, Qiuling Zheng, Haiping Hao, Hui Ye, Ping Li, Hua Yang

Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2

Acta Pharm Sin B.

doi: 10.1016/j.apsb.2021.03.021.

(IF 7.097)

1220. Mingdong Si, Meng Wu, Yingying Huo, Aiying Li, Shengjiang Guan, Donglai Ma, Zhihong Ma

Gentianella acuta mitigates cardiovascular damage and inflammation in diet-induced hypercholesterolaemic rats

Exp Ther Med.

doi: 10.3892/etm.2021.10694.

(IF 1.785)

1221. Yan Zhou, Shuai Chen, Wenxian Gu, Xiao Sun, Linxiao Wang, Liming Tang

Sinomenine hydrochloride ameliorates dextran sulfate sodium-induced colitis in mice by modulating the gut microbiota composition whilst suppressing the activation of the NLRP3 inflammasome

Exp Ther Med.

doi: 10.3892/etm.2021.10722.

(IF 1.785)

1222. Qiu Renfeng, Chen Shuxiao, Gao Peixian, Luo Kun, Feng Xuedong, Yuan Hai, Wu Xuejun, Li Gang

ADAM10 attenuates the development of abdominal aortic aneurysms in a mouse model

Mol Med Rep.

doi: 10.3892/mmr.2021.12414.

(IF 2.1)

1223. Junjun Wei, Liangliang Chen, Duidui Wang, Li Tang, Zhenhua Xie, Weifeng Chen, Shuwei Zhang, Guobin Weng

Upregulation of RIP3 promotes necroptosis via a ROS‑dependent NF‑κB pathway to induce chronic inflammation in HK‑2 cells

Mol Med Rep.

doi: 10.3892/mmr.2021.12423.

(IF 2.1)

1224. Meng Yang, Binbin Yang, Danqi Deng

Targeting of EIF4EBP1 by miR-99a-3p affects the functions of B lymphocytes via autophagy and aggravates SLE disease progression

J Cell Mol Med.

doi: 10.1111/jcmm.16991.

(IF 4.486)

1225. Shengfu Wang, Chunyan Wang, Xiao Wang, Xiang Wang, Lina Huang, Jiajie Kuai, Wei Wei, Xiaorong Lu, Shangxue Yan

Antitumor efficacy of CHMFL-KIT-110 solid dispersion in mouse xenograft models of human gastrointestinal stromal tumors

Cancer Chemother Pharmacol.

doi: 10.1007/s00280-021-04332-z.

1226. Jie Liu, Wei Ma, Cheng-Hao Zang, Guo-Dong Wang, Si-Jia Zhang, Hong-Jie Wu, Ke-Wei Zhu, Xiang-Lin Xiang, Chun-Yan Li, Kuang-Pin Liu, Jian-Hui Guo, Li-Yan Li

Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-κB signaling pathway

Ann Transl Med.

doi: 10.21037/atm-21-5752.

(IF 3.297)

1227. Lei Yu, Yuxi Chen, Shaohui Yuan, Yang Cao, Zhenggang Bi

Peiminine Induces G0/G1-Phase Arrest, Apoptosis, and Autophagy via the ROS/JNK Signaling Pathway in Human Osteosarcoma Cells in Vitro and in Vivo

Front Pharmacol.

doi: 10.3389/fphar.2021.770846.

(IF 4.225)

1228. Meixue Chen, Jing Li, Jinfeng Wang, Yuan Le, Chunfeng Liu

SMYD1 alleviates septic myocardial injury by inhibiting endoplasmic reticulum stress

Biosci Biotechnol Biochem.

doi: 10.1093/bbb/zbab167.

1229. Qiong Li, Lei Huang

MiR-148a-3p Regulates the Invasion and Odontoblastic Differentiation of Human Dental Pulp Stem Cells via the Wnt1/ β-Catenin Pathway

Int J Stem Cells.

doi: 10.15283/ijsc20118.

(IF 1.94)

1230. Congrui Jiao, Jiahong Zou, Zhenwei Chen, Feifei Zheng, Zhen Xu, Yu-Hung Lin, Qingchao Wang

Dietary Glutamine Inclusion Regulates Immune and Antioxidant System, as Well as Programmed Cell Death in Fish to Protect against Flavobacterium columnare Infection

Antioxidants (Basel).

doi: 10.3390/antiox11010044.

1231. Zhen Liu, Yaqiong Wang, Yifei Liu, Qiuqin Zhang, Wei Li, Mingsheng Dong, Xin Rui

The Conformational Structural Change of Soy Glycinin via Lactic Acid Bacteria Fermentation Reduced Immunoglobulin E Reactivity

Foods.

doi: 10.3390/foods10122969.

(IF 4.092)

1232. Xingyu Deng, Xiabin Chen, Fang Geng, Xin Tang, Zhenzhen Li, Jie Zhang, Yikai Wang, Fangqian Wang, Na Zheng, Peng Wang, Xiaohua Yu, Shurong Hou, Wei Zhang

Precision 3D printed meniscus scaffolds to facilitate hMSCs proliferation and chondrogenic differentiation for tissue regeneration

J Nanobiotechnology.

doi: 10.1186/s12951-021-01141-7.

1233. Long Miao, Juan Zhang, Lihong Yin, Yuepu Pu

TMT-Based Quantitative Proteomics Reveals Cochlear Protein Profile Alterations in Mice with Noise-Induced Hearing Loss

Int J Environ Res Public Health.

doi: 10.3390/ijerph19010382.

1234. Yichen Guo, Yawen Cheng, Jiaqi An, Yi Qi, Guogang Luo

Neuropeptide changes in an improved migraine model with repeat stimulations

Transl Neurosci.

doi: 10.1515/tnsci-2020-0201.

(IF 1.373)

1235. Yao Liu, Li Chen, Wenjun Liu, Dan Li, Jiuseng Zeng, Qiong Tang, Yuexin Zhang, Fei Luan, Nan Zeng

Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways

Front Microbiol.

doi: 10.3389/fmicb.2021.795756.

(IF 4.235)

1236. Cong Wang, Hao Chen, Hui-Hui Jiang, Bin-Bin Mao, Hao Yu

Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses

Front Neurosci.

doi: 10.3389/fnins.2021.772401.

1237. Hongjian Dai, Zengpeng Lv, Zhenwu Huang, Nanwei Ye, Simeng Li, Jingle Jiang, Ying Cheng, Fangxiong Shi

Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens

Poult Sci.

doi: 10.1016/j.psj.2021.101499.

1238. Shengyang Jin, Liang Yang, Chunqing Meng, Yu He, Kaige Ma, Wei Huang, Hong Wang

Sequential Epiphyseal Cartilage Changes of Femoral Heads in C57BL/6 Female Mice Treated with Excessive Glucocorticoids

Cartilage.

doi: 10.1177/1947603520978574.

(IF 3.857)

1239. Lili Zhang, Shilun Li, Juan Li, Yukun Li

LncRNA ORLNC1 Promotes Bone Marrow Mesenchyml Stem Cell Pyroptosis Induced by Advanced Glycation End Production by Targeting miR-200b-3p/Foxo3 Pathway

Stem Cell Rev Rep.

doi: 10.1007/s12015-021-10247-2.

(IF 5.316)

1240. Changquan Guo, Juan Dong, Yanfen Ma, Shuo Zhou, Weidong Zeng, Guang Liu, Caiqiao Zhang

LIF and bFGF enhanced chicken primordial follicle activation by Wnt/β-catenin pathway

Theriogenology.

doi: 10.1016/j.theriogenology.2021.09.008.

(IF 2.094)

1241. Xiaodan Li, Xiaolei Yao, Haiqiang Xie, Guomin Zhang, Mingtian Deng, Kaiping Deng, Xiaoxiao Gao, Yongjin Bao, Kang Li, Feng Wang

PPP2R2A affects embryonic implantation by regulating the proliferation and apoptosis of Hu sheep endometrial stromal cells

Theriogenology.

doi: 10.1016/j.theriogenology.2021.09.026.

(IF 2.094)

1242. Huihui Li, Jun Li, Xianjing Zhang, Jiaomeng Li, Cong Xi, Wenqiong Wang, Youli Lu, Lijiang Xuan

Euphornin L promotes lipid clearance by dual regulation of LDLR and PCSK9

Exp Ther Med.

doi: 10.3892/etm.2021.10817.

(IF 1.785)

1243. Xiao Lin, Ya Xing, Yihui Zhang, Biao Dong, Minmeng Zhao, Jian Wang, Tuoyu Geng, Daoqing Gong, Yun Zheng, Long Liu

Glucose participates in the formation of goose fatty liver by regulating the expression of miRNA-33/CROT

Anim Sci J.

doi: 10.1111/asj.13674.

(IF 1.399)

1244. Ting Xie, Xiaodong Chen, Wenyi Chen, Sien Huang, Xinye Peng, Lingmei Tian, Xuejie Wu, Yan Huang

Curcumin is a Potential Adjuvant to Alleviates Diabetic Retinal Injury via Reducing Oxidative Stress and Maintaining Nrf2 Pathway Homeostasis

Front Pharmacol.

doi: 10.3389/fphar.2021.796565.

(IF 4.225)

1245. Zhang'an Dai, Lin Cai, Yingyu Chen, Silu Wang, Qian Zhang, Chengde Wang, Ming Tu, Zhangzhang Zhu, Qun Li, Xianghe Lu

Brusatol Inhibits Proliferation and Invasion of Glioblastoma by Down-Regulating the Expression of ECM1

Front Pharmacol.

doi: 10.3389/fphar.2021.775680.

(IF 4.225)

1246. Junfang Li, Xiaoling Hu, Tian Luo, Yingmei Lu, Yiyue Feng, Honghua Zhang, Dan Liu, Xiaohong Fan, Yuqing Wang, Liming Jiang, Yuying Wang, Xiangyong Hao, Tao Shi, Zhen Wang

N-2-(phenylamino) benzamide derivatives as novel anti-glioblastoma agents: Synthesis and biological evaluation

Eur J Med Chem.

doi: 10.1016/j.ejmech.2021.113817.

(IF 5.572)

1247. Yue Wang, Rong Jin, Jiebiao Chen, Jinping Cao, Jianbo Xiao, Xian Li, Chongde Sun

Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination

Food Chem.

doi: 10.1016/j.foodchem.2021.130470.

(IF 6.306)

1248. Xiao-Jun Cao, Rui Wu, He-Ya Qian, Xiang Chen, Hong-Yan Zhu, Guang-Yin Xu, Ye-Zi Sun, Ping-An Zhang

Metformin attenuates diabetic neuropathic pain via AMPK/NF-κB signaling pathway in dorsal root ganglion of diabetic rats

Brain Res.

doi: 10.1016/j.brainres.2021.147663.

(IF 2.733)

1249. Dan Jiang, Ping Li, Yan Yin, Guangxi Ren, Chunsheng Liu

Molecular cloning and functional characterization of UGTs from Glycyrrhiza uralensis flavonoid pathway

Int J Biol Macromol.

doi: 10.1016/j.ijbiomac.2021.09.136.

(IF 5.162)

1250. Yinghui Wang, Yihang Xie, Boxuan Sun, Yuwei Guo, Ling Song, Dawit Eman Mohammednur, Chunyan Zhao

The degradation of Rap1GAP via E6AP-mediated ubiquitin-proteasome pathway is associated with HPV16/18-infection in cervical cancer cells

Infect Agent Cancer.

doi: 10.1186/s13027-021-00409-9.

1251. Lin Liu, Yongwu Yang, Rui Fang, Weining Zhu, Jingxue Wu, Xiaoyun Li, Jay V Patankar, Wei Li

Giardia duodenalis and Its Secreted PPIB Trigger Inflammasome Activation and Pyroptosis in Macrophages through TLR4-Induced ROS Signaling and A20-Mediated NLRP3 Deubiquitination

Cells.

doi: 10.3390/cells10123425.

(IF 4.366)

1252. Ziqing Wang, Wenwen Mu, Zhaotang Gong, Guoyun Liu, Jie Yang

Meta-substituted piperlongumine derivatives attenuate inflammation in both RAW264.7 macrophages and a mouse model of colitis

Bioorg Chem.

doi: 10.1016/j.bioorg.2021.105465.

(IF 4.831)

1253. Zhuo Li, Zhiwen Lian, Jianchao Ma, Li Zhang, Xingji Lian, Shuangxin Liu, Jianteng Xie, Zhonglin Feng, Ting Lin, Hong Zhang, Xinling Liang

Integrin β3 overexpression contributes to podocyte injury through inhibiting RhoA/YAP signaling pathway

Bioengineered.

doi: 10.1080/21655979.2021.1906097.

(IF 2.205)

1254. Yan Li, Xiaoxiao Xu, Liyan Wang, Xuemei Li, Running Liu, Li Zhang, Yali Xu

REDD1 (regulated in development and DNA damage-1)/autophagy inhibition ameliorates fine particulate matter (PM2.5) -induced inflammation and apoptosis in BEAS-2B cells

Bioengineered.

doi: 10.1080/21655979.2021.1917227.

(IF 2.205)

1255. Hui Liu, Zuofei Chi, Hong Jin, Wei Yang

MicroRNA miR-188-5p as a mediator of long non-coding RNA MALAT1 regulates cell proliferation and apoptosis in multiple myeloma

Bioengineered.

doi: 10.1080/21655979.2021.1920325.

(IF 2.205)

1256. Mengyao Mu, Hongjing Zhao, Yu Wang, Menghao Guo, Xiaopan Nie, Yachen Liu, Mingwei Xing

Interferon-beta, interferon-gamma and their fusion interferon of Siberian tigers (Panthera tigris altaica) in China are involved in positive-feedback regulation of interferon production

Dev Comp Immunol.

doi: 10.1016/j.dci.2021.104211.

(IF 3.192)

1257. Xin Wu, Zongqi Wang, Haiying Li, Xueshun Xie, Jiang Wu, Haitao Shen, Xiang Li, Zhong Wang, Gang Chen

Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid hemorrhage in rats

Front Med.

doi: 10.1007/s11684-021-0879-9.

1258. Qi Jia, Weifeng Tian, Binbin Li, Wen Chen, Wenjie Zhang, Yang Xie, Na Cheng, Qi Chen, Jianru Xiao, Yiwang Zhang, Jian Yang, Shu Wang

Transient Receptor Potential channels, TRPV1 and TRPA1 in melanocytes synergize UV-dependent and UV-independent melanogenesis

Br J Pharmacol.

doi: 10.1111/bph.15643.

1259. Yi Zhou, Zhi Tan, Hao Huang, Yonglian Zeng, Shilian Chen, Jie Wei, Guozhen Huang, Chaosi Qian, Guandou Yuan, Songqing He

Baicalein pre-treatment alleviates hepatic ischemia/reperfusion injury in mice by regulating the Nrf2/ARE pathway

Exp Ther Med.

doi: 10.3892/etm.2021.10816.

(IF 1.785)

1260. Yuanyang Li, Yufan Zhang, Xiangzhong Zhou, Xianghong Lei, Xinhang Li, Liping Wei

Dynamic observation of 5-fluorouracil-induced myocardial injury and mitochondrial autophagy in aging rats

Exp Ther Med.

doi: 10.3892/etm.2021.10886.

(IF 1.785)

1261. Tong-Zhuang Wang, Guo-Wei Zuo, Ling Yao, Chun-Lin Yuan, Hai-Fei Li, Ying Lai, Zhi-Wei Chen, Jun Zhang, Ya-Qian Jin, Johji Yamahara, Jian-Wei Wang

Ursolic acid ameliorates adipose tissue insulin resistance in aged rats via activating the Akt-glucose transporter 4 signaling pathway and inhibiting inflammation

Exp Ther Med.

doi: 10.3892/etm.2021.10901.

(IF 1.785)

1262. Yuying Fan, Xiaoli Ren, Yingxue Wang, Enshuang Xu, Shuang Wang, Ruidong Ge, Yun Liu

Metformin inhibits the proliferation of canine mammary gland tumor cells through the AMPK/AKT/mTOR signaling pathway in vitro

Oncol Lett.

doi: 10.3892/ol.2021.13113.

(IF 2.311)

1263. Yali Guan, Pengfei Li, Yingshuo Liu, Lan Guo, Qingwen Wu, Yuefa Cheng

Protective multi‑target effects of DL‑3‑n‑butylphthalide combined with 3‑methyl‑1‑phenyl‑2‑pyrazolin‑5‑one in mice with ischemic stroke

Mol Med Rep.

doi: 10.3892/mmr.2021.12490.

(IF 2.1)

1264. Bugao Guan, Guangrun Li, Benhai Wan, Xiang Guo, Desong Huang, Jun Ma, Ping Gong, Jinbao Guo, Yanzhi Bu

RNA-binding protein RBM38 inhibits colorectal cancer progression by partly and competitively binding to PTEN 3'UTR with miR-92a-3p

Environ Toxicol.

doi: 10.1002/tox.23356.

(IF 3.118)

1265. Xiuge Gao, Chunlei Ji, Junqi Wang, Xinhao Song, Runan Zuo, Jingjing Zhang, Xiaorong Chen, Hui Ji, Lin Peng, Dawei Guo, Shanxiang Jiang

Maduramicin induces cardiotoxicity via Rac1 signaling-independent methuosis in H9c2 cells

J Appl Toxicol.

doi: 10.1002/jat.4175.

(IF 2.997)

1266. Yang Xie, Feng Wang, Jun Yu, Jing Zhang, Yuting Liu, Mengying Li, Jian Qi

Silencing of MBD2 and EZH2 inhibits the proliferation of colorectal carcinoma cells by rescuing the expression of SFRP

Oncol Rep.

doi: 10.3892/or.2021.8201.

(IF 3.417)

1267. Wenjing Niu, Haibo Wang, Bo Wang, Xueying Mao, Min Du

Resveratrol improves muscle regeneration in obese mice through enhancing mitochondrial biogenesis

J Nutr Biochem.

doi: 10.1016/j.jnutbio.2021.108804.

(IF 4.873)

1268. Gang Zhao, Xiaobao Shi, Zhanbo Sun, Pengfei Zhao, Zaiming Lu

PAQR4 promotes the development of hepatocellular carcinoma by activating PI3K/AKT pathway

Acta Biochim Biophys Sin (Shanghai).

doi: 10.1093/abbs/gmab143.

1269. Bo Li, Xianyi Liu, Guogang Wu, Jiawen Liu, Shouliang Cai, Fuxin Wang, Chunyu Yang, Jisheng Liu

MicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2

Bioengineered.

doi: 10.1080/21655979.2021.1996505.

(IF 2.205)

1270. Huijie Fan, Yanrong Li, Mengying Sun, Wushuai Xiao, Lijuan Song, Qing Wang, Bo Zhang, Jiezhong Yu, Xiaoming Jin, Cungen Ma, Zhi Chai

Hyperoside Reduces Rotenone-induced Neuronal Injury by Suppressing Autophagy

Neurochem Res.

doi: 10.1007/s11064-021-03404-z.

(IF 3.038)

1271. Jianyun Cao, Xuebing Qiu, Yun Gao, Liangliang Cai

Puerarin promotes the osteogenic differentiation of rat dental follicle cells by promoting the activation of the nitric oxide pathway

Tissue Cell.

doi: 10.1016/j.tice.2021.101601.

(IF 1.837)

1272. Qi Zhang, Fan Zhu, Yuyin Luo, Jun Liao, Jiancheng Cao, Tao Xue

Platelet miR-107 Participates in Clopidogrel Resistance after PCI Treatment by Regulating P2Y12

Acta Haematol.

doi: 10.1159/000517811.

1273. Li Wang, Yan Zhao, Shuang Yao, Hongfei Lou, Luo Zhang

Vitamin D Improves the Effect of Glucocorticoids on Attenuating Lipopolysaccharide-Induced IL-6 Production via TLR4/NF-κB Pathway in Human Respiratory Epithelial Cells

Int Arch Allergy Immunol.

doi: 10.1159/000524855.

1274. Han Li, Jun-Xian Xu, Tiao-Chun Cheng, Li-Jun Tian, Jin-Feng Lin, Xi Luo, Zhao-Lian Bian, Xu-Dong Han

Inhibition of Phosphoinositide 3-Kinase Gamma Protects Endothelial Cells via the Akt Signaling Pathway in Sepsis-Induced Acute Kidney Injury

Kidney Blood Press Res.

doi: 10.1159/000526916.

1275. Zefeng Wang, Qianfei Cui, Ling Shi, Meiling Zhang, Peng Song, Dongzhu Duan, Wenjing Guo

Network Pharmacology-based Prediction and Verification of Shikonin for Treating Colorectal Cancer

Recent Pat Anticancer Drug Discov.

doi: 10.2174/1574892817666211224142100.

1276. Chunyan Li, Yuehua Zhu, Yuanyuan Wu, Meiyuan Fu, Yiling Wu, Yuehong Wu, Yinger Qiu, Hui Zhang, Mingxing Ding

Oridonin Alleviates LPS-Induced Depression by Inhibiting NLRP3 Inflammasome via Activation of Autophagy

Front Med (Lausanne).

doi: 10.3389/fmed.2021.813047.

1277. Leyi Zhang, Chenglong Lu, Li Kang, Yingji Li, Wenjing Tang, Dengfa Zhao, Shengyuan Yu, Ruozhuo Liu

Temporal characteristics of astrocytic activation in the TNC in a mice model of pain induced by recurrent dural infusion of inflammatory soup

J Headache Pain.

doi: 10.1186/s10194-021-01382-9.

(IF 4.797)

1278. Peiyan Zhao, Xiaodan Sun, Hui Li, Yan Liu, Yanan Cui, Lin Tian, Ying Cheng

c-Myc Targets HDAC3 to Suppress NKG2DL Expression and Innate Immune Response in N-Type SCLC through Histone Deacetylation

Cancers (Basel).

doi: 10.3390/cancers14030457.

1279. Qiao Mou, Yu-Wei Yang, Lu Chen, Ting Fang, Yu-Chang Yao, Zhi-Qiang Du, Cai-Xia Yang

Melatonin mitigates Chloroquine-induced defects in porcine immature Sertoli cells

Theriogenology.

doi: 10.1016/j.theriogenology.2021.10.005.

(IF 2.094)

1280. Rongchen Shi, Kun Zhao, Teng Wang, Jing Yuan, Dapeng Zhang, Wei Xiang, Jin Qian, Na Luo, Yong Zhou, Bo Tang, Chuan Li, Hongming Miao

5-aza-2'-deoxycytidine potentiates anti-tumor immunity in colorectal peritoneal metastasis by modulating ABC A9-mediated cholesterol accumulation in macrophages

Theranostics.

doi: 10.7150/thno.66420.

(IF 8.579)

1281. Qiushi Feng, Panpan Yang, He Wang, Congshan Li, Tomoka Hasegawa, Zhaopeng Liu, Minqi Li

ID09, A Newly-Designed Tubulin Inhibitor, Regulating the Proliferation, Migration, EMT Process and Apoptosis of Oral Squamous Cell Carcinoma

Int J Biol Sci.

doi: 10.7150/ijbs.65824.

(IF 4.858)

1282. Haiyang Zhao, Tingting Zhao, Jihong Yang, Qianqian Huang, Hua Wu, Yueyun Pan, Hui Wang, Yun Qian

Epimedium protects against dyszoospermia in mice with Pex3 knockout by exerting antioxidant effects and regulating the expression level of P16

Cell Death Dis.

doi: 10.1038/s41419-021-04435-8.

(IF 6.304)

1283. Chenxi Shi, Jiaqi Wang, Ruichen Zhang, Muhammad Ishfaq, Ying Li, Ruihui Zhang, Chuanbiao Si, Rui Li, Changwen Li, Fangping Liu

Dihydromyricetin alleviates Escherichia coli lipopolysaccharide-induced hepatic injury in chickens by inhibiting the NLRP3 inflammasome

Vet Res.

doi: 10.1186/s13567-022-01024-1.

(IF 3.357)

1284. Xin-Yi Wu, Ya-Jun Chen, Chang-An Liu, Jun-Hua Gong, Xue-Song Xu

STING Induces Liver Ischemia-Reperfusion Injury by Promoting Calcium-Dependent Caspase 1-GSDMD Processing in Macrophages

Oxid Med Cell Longev.

doi: 10.1155/2022/8123157.

(IF 5.076)

1285. Mo Zhu, Baofei Jiang, Hao Zuo, Xiaopeng Wang, Hengfa Ge, Ziming Huang

LIM-Domain-Binding Protein 1 Mediates Cell Proliferation and Drug Resistance in Colorectal Cancer

Front Surg.

doi: 10.3389/fsurg.2021.790380.

1286. Xiaobin Fang, Mengmeng Li, Weiyi Zhang, Jingyi Li, Tao Zhu

Thrombin induces pro-inflammatory and anti-inflammatory cytokines secretion from human mast cell line (HMC-1) via protease-activated receptors

Mol Immunol.

doi: 10.1016/j.molimm.2021.11.012.

(IF 3.641)

1287. Dongmin Xu, Li Li, Leilei Tang, Ming Guo, Jie Yang

Perfluorooctane sulfonate induces heart toxicity involving cardiac apoptosis and inflammation in rats

Exp Ther Med.

doi: 10.3892/etm.2021.10936.

(IF 1.785)

1288. Fuxin Zhao, Wei Chen, Hui Zhou, Peter S Reinach, Yuhan Wang, Suh-Hang H Juo, Zhenglin Yang, Anquan Xue, Yi Shi, Chung-Ling Liang, Changqing Zeng, Jia Qu, Xiangtian Zhou

PDE4B Proposed as a High Myopia Susceptibility Gene in Chinese Population

Front Genet.

doi: 10.3389/fgene.2021.775797.

(IF 3.258)

1289. Fenglian Yan, Dalei Cheng, Haiyan Wang, Min Gao, Junfeng Zhang, Hongyan Cheng, Changying Wang, Hui Zhang, Huabao Xiong

Corilagin Ameliorates Con A-Induced Hepatic Injury by Restricting M1 Macrophage Polarization

Front Immunol.

doi: 10.3389/fimmu.2021.807509.

(IF 5.085)

1290. Shuhua Zhang, Jianqun Xu, Huan Cao, Mi Jiang, Jun Xiong

KB-68A7.1 Inhibits Hepatocellular Carcinoma Development Through Binding to NSD1 and Suppressing Wnt/β-Catenin Signalling

Front Oncol.

doi: 10.3389/fonc.2021.808291.

(IF 4.848)

1291. Wancai Que, Zhaoyang Wu, Maohua Chen, Binqing Zhang, Chuihuai You, Hailing Lin, Zhichang Zhao, Maobai Liu, Hongqiang Qiu, Yu Cheng

Molecular Mechanism of Gelsemium elegans (Gardner and Champ.) Benth. Against Neuropathic Pain Based on Network Pharmacology and Experimental Evidence

Front Pharmacol.

doi: 10.3389/fphar.2021.792932.

(IF 4.225)

1292. Shuo Zhang, Peng Wang, Binwu Hu, Weijian Liu, Xiao Lv, Songfeng Chen, Zengwu Shao

HSP90 Inhibitor 17-AAG Attenuates Nucleus Pulposus Inflammation and Catabolism Induced by M1-Polarized Macrophages

Front Cell Dev Biol.

doi: 10.3389/fcell.2021.796974.

(IF 5.201)

1293. Qi Li, Jun Mo, Baichen Xiong, Qinghong Liao, Ying Chen, Yuanyuan Wang, Shuaishuai Xing, Siyu He, Weiping Lyu, Ning Zhang, Haopeng Sun

Discovery of Resorcinol-Based Polycyclic Structures as Tyrosinase Inhibitors for Treatment of Parkinson's Disease

ACS Chem Neurosci.

doi: 10.1021/acschemneuro.1c00560.

(IF 4.486)

1294. San-Qiao Yang, Yi-Yun Tang, Dan Zeng, Qing Tian, Hai-Jun Wei, Chun-Yan Wang, Ping Zhang, Yong-Jun Chen, Wei Zou, Xiao-Qing Tang

Sodium hydrosulfide reverses β2-microglobulin-induced depressive-like behaviors of male Sprague-Dawley rats: Involving improvement of synaptic plasticity and enhancement of Warburg effect in hippocamp

Behav Brain Res.

doi: 10.1016/j.bbr.2021.113562.

(IF 2.977)

1295. Xuling Zhang, Tao Huang, Lubo Lang, Ling Yu

Effects of lysophosphatidic acid receptor 5 on NLRC4 inflammasome in brain tissues of transient cerebral ischemia/reperfusion rat

Hum Exp Toxicol.

doi: 10.1177/09603271221078870.

(IF 2.067)

1296. Li Wu, Jing Li, Fang Zhao, Yi Xiang

MiR-340-5p inhibits Müller cell activation and pro-inflammatory cytokine production by targeting BMP4 in experimental diabetic retinopathy

Cytokine.

doi: 10.1016/j.cyto.2021.155745.

(IF 2.952)

1297. Zhaoming Sun, Lixiang Song, Jiazhen Li

Knockdown of small nucleolar RNA host gene 10 (SNHG10) alleviates the injury of human neuroblastoma cells via the miR-1277-5p/insulin substrate receptor 2 axis

Bioengineered.

doi: 10.1080/21655979.2021.2012623.

(IF 2.205)

1298. Ping Liu, Xiaoji Cong, Shengjie Liao, Xinglong Jia, Xiaomin Wang, Wei Dai, Linhui Zhai, Lei Zhao, Jing Ji, Duan Ni, Zhiwei Liu, Yulu Chen, Lulu Pan, Wei Liu, Jian Zhang, Min Huang, Bin Liu, Minjia Tan

Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis

Cell Death Differ.

doi: 10.1038/s41418-021-00827-7.

(IF 10.717)

1299. Wu Jiang, Wei Zou, Min Hu, Qing Tian, Fan Xiao, Min Li, Ping Zhang, Yong-Jun Chen, Jia-Mei Jiang

Hydrogen sulphide attenuates neuronal apoptosis of substantia nigra by re-establishing autophagic flux via promoting leptin signalling in a 6-hydroxydopamine rat model of Parkinson's disease

Clin Exp Pharmacol Physiol.

doi: 10.1111/1440-1681.13587.

1300. Lijie Chen, Xing Niu, Xue Qiao, Sai Liu, Hongmei Ma, Xueqing Shi, Xuemei He, Ming Zhong

Characterization of Interplay Between Autophagy and Ferroptosis and Their Synergistical Roles on Manipulating Immunological Tumor Microenvironment in Squamous Cell Carcinomas

Front Immunol.

doi: 10.3389/fimmu.2021.739039.

(IF 5.085)

1301. Ling-Yun Hao, Ming Zhang, Yang Tao, Hengjun Xu, Qiaoqiao Liu, Kehui Yang, Runa Wei, Huimin Zhou, Tong Jin, Xiao-Dan Liu, Zhouya Xue, Wen Shen, Jun-Li Cao, Zhiqiang Pan

miRNA-22 Upregulates Mtf1 in Dorsal Horn Neurons and Is Essential for Inflammatory Pain

Oxid Med Cell Longev.

doi: 10.1155/2022/8622388.

(IF 5.076)

1302. Kai Qu, Caihong Wang, Lu Huang, Xian Qin, Kun Zhang, Yuan Zhong, Qingfeng Ma, Wenhua Yan, Tianhan Li, Qin Peng, Yi Wang, Hans Gregersen, Chaojun Tang, Juhui Qiu, Guixue Wang

TET1s deficiency exacerbates oscillatory shear flow-induced atherosclerosis

Int J Biol Sci.

doi: 10.7150/ijbs.69281.

(IF 4.858)

1303. Yanbo Kou, Xingping Zheng, Liyuan Meng, Mengnan Liu, Shihong Xu, Qiyue Jing, Shenghan Zhang, Hanying Wang, Jinzhi Han, Zhuanzhuan Liu, Yanxia Wei, Yugang Wang

The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota

Front Immunol.

doi: 10.3389/fimmu.2022.773341.

(IF 5.085)

1304. Mengge Bai, Heming Yu, Chong Chen, Xingzhe Xu, Yong He, Yue Wang, Yu Tian, Zhonghao Wu, Tianlan Lan, Yan Li, Xiangyu Chen, Zhi Chen, Libo Zhao, Liang Fang, Deyu Yang, Ke Cheng, Peng Xie

Pigment epithelium-derived factor may induce antidepressant phenotypes in mice by the prefrontal cortex

Neurosci Lett.

doi: 10.1016/j.neulet.2021.136423.

(IF 2.274)

1305. Xiangze Li, Zhan Su, Kaiying Shen, Qi Wang, Chencheng Xu, Fuqiang Wang, Yuchi Zhang, Dapeng Jiang

Eugenol-Preconditioned Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Antioxidant Capacity of Tendon Stem Cells In Vitro and In Vivo

Oxid Med Cell Longev.

doi: 10.1155/2022/3945195.

(IF 5.076)

1306. Mengmeng Duan, Yang Liu, Daimo Guo, Shiyi Kan, Zhixing Niu, Xiaohua Pu, Mingru Bai, Demao Zhang, Wei Du, Jing Xie

TGF-β2 increases cell-cell communication in chondrocytes via p-Smad3 signalling

Biochim Biophys Acta Mol Cell Res.

doi: 10.1016/j.bbamcr.2021.119175.

1307. Hongbin Peng, Pingjiang Ge

Long non‑coding RNA HCG18 facilitates the progression of laryngeal and hypopharyngeal squamous cell carcinoma by upregulating FGFR1 via miR‑133b

Mol Med Rep.

doi: 10.3892/mmr.2021.12562.

(IF 2.1)

1308. Jingwen Chen, Xin Wu, Yanyi Wang, Yunfeng Pan, Yan Ren, Yusaku Nakabeppu, Yimei Fan, Yaping Wang

Mutyh deficiency downregulates mitochondrial fusion proteins and causes cardiac dysfunction via α-ketoglutaric acid reduction with oxidative stress

Free Radic Res.

doi: 10.1080/10715762.2022.2036336.

1309. Juntao Li, Linqing Sun, Yanjun Chen, Jinghan Zhu, Jin Shen, Jiayu Wang, Yanzheng Gu, Guangbo Zhang, Mingyuan Wang, Tongguo Shi, Weichang Chen

Gastric cancer-derived exosomal miR-135b-5p impairs the function of Vγ9Vδ2 T cells by targeting specificity protein 1

Cancer Immunol Immunother.

doi: 10.1007/s00262-021-02991-8.

1310. Mei Yang, Liangliang Ju, Changlian Li, Han Cheng, Na Li, Qi Zhang, Shu Sun, Liu Ding, Xinmiao Sui, Chao Zhang, Mingwei Yang, Jiyu Cao, Rui Ding

MiR-582-3p participates in the regulation of biological behaviors of A549 cells by ambient PM2.5 exposure

Environ Sci Pollut Res Int.

doi: 10.1007/s11356-021-16801-2.

1311. Yu-Hang Zhang, Wen-Yu Wang, Xiao-Cong Pang, Zhi Wang, Cheng-Zhuo Wang, Hang Zhou, Bo Zheng, Yi-Min Cui

Thymosin-α1 binds with ACE and downregulates the expression of ACE2 in human respiratory epithelia

Front Biosci (Landmark Ed).

doi: 10.31083/j.fbl2702048.

1312. Yankun Zhang, Min Sun, Lifen Gao, Xiaohong Liang, Chunhong Ma, Jinghui Lu, Xuetian Yue

ZHX2 inhibits thyroid cancer metastasis through transcriptional inhibition of S100A14

Cancer Cell Int.

doi: 10.1186/s12935-022-02499-w.

(IF 4.175)

1313. Tingting Cheng, Cheng Wang, Qianqian Lu, Yuru Cao, Weiwei Yu, Wenzhen Li, Ben Liu, Xue Gao, Junhong Lü, Xiaohong Pan

Metformin inhibits the tumor-promoting effect of low-dose resveratrol, and enhances the anti-tumor activity of high-dose resveratrol by increasing its reducibility in triple negative breast cancer

Free Radic Biol Med.

doi: 10.1016/j.freeradbiomed.2022.01.010.

1314. Gang Yu, Wanjing Chen, Xianghua Li, Liang Yu, Yanyan Xu, Qiang Ruan, Yawei He, Yong Wang

TWIST1-EP300 Expedites Gastric Cancer Cell Resistance to Apatinib by Activating the Expression of COL1A2

Anal Cell Pathol (Amst).

doi: 10.1155/2022/5374262.

1315. Meng Zhao, Houting Lv, Na Yang, Guang-Hua Peng

Rapamycin Improved Retinal Function and Morphology in a Mouse Model of Retinal Degeneration

Front Neurosci.

doi: 10.3389/fnins.2022.846584.

1316. Haibo Ruan, Zhenzhen Dai, Jinyu Yan, Xiaoxi Long, Yi Chen, Youlin Yang, Qian Yang, Jun Zhu, Meiyun Zheng, Xiahui Zhang

ZBTB24 (Zinc Finger and BTB Domain Containing 24) prevents recurrent spontaneous abortion by promoting trophoblast proliferation, differentiation and migration

Bioengineered.

doi: 10.1080/21655979.2021.2019655.

(IF 2.205)

1317. Mingyi Li, Chenxia Li, Huarong Zheng, Zhen Zhou, Wenjian Yang, Yu Gong, Xia Wu, Leyu Li

CircRNA_0001795 sponges miRNA-339-5p to regulate yes-associated protein 1 expression and attenuate osteoporosis progression

Bioengineered.

doi: 10.1080/21655979.2021.2022074.

(IF 2.205)

1318. Kaixiang Xu, Wanyun Zhu, Anyong Xu, Zhe Xiong, Di Zou, Heng Zhao, Deling Jiao, Yubo Qing, Muhammad Ameen Jamal, Hong-Jiang Wei, Hong-Ye Zhao

Inhibition of FOXO1‑mediated autophagy promotes paclitaxel‑induced apoptosis of MDA‑MB‑231 cells

Mol Med Rep.

doi: 10.3892/mmr.2022.12588.

(IF 2.1)

1319. Xinglin Li, Xiaoyun Chen, Jiebing Gao, Jianzhong Xian, Zhijun Li, Lei Bi, Min Yang, Shuai Yang, Hongjun Jin, Hong Shan

Loss-of-function Mutations K11E or E271K Lead to Novel Tumor Suppression, Implicate Nucleolar Helicase DDX24 Oncogenicity

Int J Med Sci.

doi: 10.7150/ijms.67840.

(IF 2.523)

1320. Nanwei Ye, Zengpeng Lv, Zhenwu Huang, Ying Cheng, Quanwei Wei, Fangxiong Shi

Dietary folic acid supplementation improves semen quality and spermatogenesis through altering autophagy and histone methylation in the testis of aged broiler breeder roosters

Theriogenology.

doi: 10.1016/j.theriogenology.2021.12.032.

(IF 2.094)

1321. Caiyun Yu, Dong Wang, Yichun Tong, Qiming Li, Weiren Yang, Tian Wang, Zaibin Yang

Trans-Anethole Alleviates Subclinical Necro-Haemorrhagic Enteritis-Induced Intestinal Barrier Dysfunction and Intestinal Inflammation in Broilers

Front Microbiol.

doi: 10.3389/fmicb.2022.831882.

(IF 4.235)

1322. Yue Tian, Zhifa Zhang, Zijing Zhang, Xiaofeng Dai

Hsa_circRNA_0040462: a sensor of cells' response to CAP treatment with double-edged roles on breast cancer malignancy

Int J Med Sci.

doi: 10.7150/ijms.66940.

(IF 2.523)

1323. Yun Li, Hui Xiong

Correlation of LAGE3 with unfavorable prognosis and promoting tumor development in HCC via PI3K/AKT/mTOR and Ras/RAF/MAPK pathways

BMC Cancer.

doi: 10.1186/s12885-022-09398-3.

(IF 3.15)

1324. Yufei Huang, Xiaoya Chu, Yafei Zhang, Sheng Yang, Yonghong Shi, Qiusheng Chen

Transformation of Mitochondrial Architecture and Dynamics in the Chinese Soft-Shelled Turtle ( Pelodiscus sinensis) During Hibernation

Microsc Microanal.

doi: 10.1017/S1431927622000484.

(IF 3.414)

1325. Jianguo Chen, Tianyu Huang, Ruiquan Liu, Chenyu Wang, Haiyue Jiang, Hengyun Sun

Congenital microtia patients: the genetically engineered exosomes released from porous gelatin methacryloyl hydrogel for downstream small RNA profiling, functional modulation of microtia chondrocytes

J Nanobiotechnology.

doi: 10.1186/s12951-022-01352-6.

1326. Yan-Ran Sheng, Wen-Ting Hu, Hui-Hui Shen, Chun-Yan Wei, Yu-Kai Liu, Xiao-Qian Ma, Ming-Qing Li, Xiao-Yong Zhu

An imbalance of the IL-33/ST2-AXL-efferocytosis axis induces pregnancy loss through metabolic reprogramming of decidual macrophages

Cell Mol Life Sci.

doi: 10.1007/s00018-022-04197-2.

(IF 6.496)

1327. Meifang Yan, Junjian Li, Li Yan, Xue Li, Jie-Guang Chen

Transcription factor Foxp1 is essential for the induction of choroidal neovascularization

Eye Vis (Lond).

doi: 10.1186/s40662-022-00281-7.

1328. Xiaomi Ding, Jing Zhou, Li Zhao, Mingyue Chen, Shenglin Wang, Ming Zhang, Xiaodong Zhang, Guohui Jiang

Intestinal Flora Composition Determines Microglia Activation and Improves Epileptic Episode Progress

Front Cell Infect Microbiol.

doi: 10.3389/fcimb.2022.835217.

1329. Fengfeng Li, Man Jiang, Minghui Ma, Xuyang Chen, Yidan Zhang, Yixin Zhang, Yuanyuan Yu, Yunfeng Cui, Jiahui Chen, Hui Zhao, Zhijie Sun, Deli Dong

Anthelmintics nitazoxanide protects against experimental hyperlipidemia and hepatic steatosis in hamsters and mice

Acta Pharm Sin B.

doi: 10.1016/j.apsb.2021.09.009.

(IF 7.097)

1330. Yongsheng Yu, Xiaochun Xue, Wendong Tang, Li Su, Lei Zhang, Yuefan Zhang

Cytosolic DNA‒Mediated STING-Dependent Inflammation Contributes to the Progression of Psoriasis

J Invest Dermatol.

doi: 10.1016/j.jid.2021.08.430.

(IF 7.143)

1331. Chen Wang, Yihui He, Zhijie You, Xin Chen

TMSB10 Promotes Progression of Clear Cell Renal Cell Carcinoma via JUN Transcription Regulation

Ann Clin Lab Sci.

(IF 0.927)

1332. Yue Yin, Yuanpan Yin, Hao Yang, Zhuanggui Chen, Jun Zheng, Bo Peng

Vibrio alginolyticus Survives From Ofloxacin Stress by Metabolic Adjustment

Front Microbiol.

doi: 10.3389/fmicb.2022.818923.

(IF 4.235)

1333. Qiwei Du, Zuguo Yuan, Xiaoling Huang, Yuqing Huang, Jie Zhang, Rongguo Li

miR-26b-5p suppresses chemoresistance in breast cancer by targeting serglycin

Anticancer Drugs.

doi: 10.1097/CAD.0000000000001268.

1334. Xiao Hu, Qiongzhen Zeng, Ji Xiao, Shurong Qin, Yuan Wang, Tianhao Shan, Di Hu, Yexuan Zhu, Kaisheng Liu, Kai Zheng, Yifei Wang, Zhe Ren

Herpes Simplex Virus 1 Induces Microglia Gasdermin D-Dependent Pyroptosis Through Activating the NLR Family Pyrin Domain Containing 3 Inflammasome

Front Microbiol.

doi: 10.3389/fmicb.2022.838808.

(IF 4.235)

1335. Ruonan Zhai, Yuan Liu, Jiahao Tong, Ying Yu, Lin Yang, Yong Gu, Jianying Niu

Empagliflozin Ameliorates Preeclampsia and Reduces Postpartum Susceptibility to Adriamycin in a Mouse Model Induced by Angiotensin Receptor Agonistic Autoantibodies

Front Pharmacol.

doi: 10.3389/fphar.2022.826792.

(IF 4.225)

1336. Yue-Tao Chen, Ke-Xin Yang, Zhen-Yuan Dai, Huan Yi, Xuan-Xian Peng, Hui Li, Zhuang-Gui Chen

Repressed Central Carbon Metabolism and Its Effect on Related Metabolic Pathways in Cefoperazone/Sulbactam-Resistant Pseudomonas aeruginosa

Front Microbiol.

doi: 10.3389/fmicb.2022.847634.

(IF 4.235)

1337. Zhang Bin-Bin, Zha Xi Da-Wa, Li Chao, Zhang Lan-Tao, Wu Tao, Lu Chuan, Liu Chao-Zheng, Li De-Chun, Feng Chang, Wei Shu-Qing, Dong Zu-Nan, Pei Xian-Wei, Zhi-Xia Zhang, Li Ke-Wen

M2 macrophagy-derived exosomal miRNA-26a-5p induces osteogenic differentiation of bone mesenchymal stem cells

J Orthop Surg Res.

doi: 10.1186/s13018-022-03029-0.

(IF 1.777)

1338. Langen Zhuang, Xiaoxu Ge, Xiaolei Hu, Qingqing Yang, Xiaoyan Pei, Guoxi Jin

miR-543 regulates high glucose-induced fibrosis and autophagy in diabetic nephropathy by targeting TSPAN8

BMC Nephrol.

doi: 10.1186/s12882-022-02716-8.

(IF 1.913)

1339. Rui Dong, Yuqiang Han, Linhao Jiang, Shuai Liu, Fujun Zhang, Liangyu Peng, Zimo Wang, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu

Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice

J Neuroinflammation.

doi: 10.1186/s12974-022-02424-y.

1340. Haikun Song, Cen Wang, Chenggang Zhu, Ziying Wang, Huiya Yang, Peng Wu, Xiaotian Cui, Juan Botas, Yongjun Dang, Yu Ding, Yiyan Fei, Boxun Lu

Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide

Proc Natl Acad Sci U S A.

doi: 10.1073/pnas.2114303119.

1341. Lai Wang, Lijun Zhu, Zuguo Zheng, Lingchang Meng, Hanling Liu, Keke Wang, Jun Chen, Ping Li, Hua Yang

Mevalonate pathway orchestrates insulin signaling via RAB14 geranylgeranylation-mediated phosphorylation of AKT to regulate hepatic glucose metabolism

Metabolism.

doi: 10.1016/j.metabol.2021.155120.

(IF 6.159)

1342. Shenggui Lu, Xinmiao Wu, Shuai Xin, Jing Zhang, Hanying Lin, Yu Miao, Yixin Li

Knockdown of circ_0001679 alleviates lipopolysaccharide-induced MLE-12 lung cell injury by regulating the miR-338-3p/ mitogen-activated protein kinase 1 axis

Bioengineered.

doi: 10.1080/21655979.2022.2034564.

(IF 2.205)

1343. Zi-Yi Chen, Jie Li, Shu-Di Zhu, Zhi-Di Li, Jia-Lin Yu, Jie Wu, Chong Zhang, Ling-Hui Zeng

Harmine reinforces the effects of regorafenib on suppressing cell proliferation and inducing apoptosis in liver cancer cells

Exp Ther Med.

doi: 10.3892/etm.2022.11132.

(IF 1.785)

1344. Guoying Guan, Jinjiao Xie, Yamei Dai, Hui Han

TFPI2 suppresses the interaction of TGF-β2 pathway regulators to promote endothelial-mesenchymal transition in diabetic nephropathy

J Biol Chem.

doi: 10.1016/j.jbc.2022.101725.

(IF 4.238)

1345. Lexin He, Shixiang Zhou, Weihong Li, Qi Wang, Zhenhua Qi, Pingkun Zhou, Zhidong Wang, Jing Chen, Yaqiong Li, Zhongwu Lin

BPIFA2 as a Novel Early Biomarker to Identify Fatal Radiation Injury After Radiation Exposure

Dose Response.

doi: 10.1177/15593258221086478.

1346. Chengkuan Sun, Guangzhi Wu, Zhan Zhang, Rangjuan Cao, Shusen Cui

Protein Tyrosine Phosphatase Receptor Type D Regulates Neuropathic Pain After Nerve Injury via the STING-IFN-I Pathway

Front Mol Neurosci.

doi: 10.3389/fnmol.2022.859166.

(IF 4.057)

1347. Caiyun Yu, Yichun Tong, Qiming Li, Tian Wang, Zaibin Yang

Trans-anethole Ameliorates Intestinal Injury Through Activation of Nrf2 Signaling Pathway in Subclinical Necrotic Enteritis-Induced Broilers

Front Vet Sci.

doi: 10.3389/fvets.2022.877066.

(IF 2.245)

1348. Jiandong Li, Wenda Cen, Chenhao Tong, Luna Wang, Weiguang Zhang, Shiqing Deng, Jianhua Yu, Baochun Lu

Fangchinoline induces gallbladder cancer cell apoptosis by suppressing PI3K/Akt/XIAP axis

PLoS One.

doi: 10.1371/journal.pone.0266738.

(IF 2.74)

1349. Sha-Sha Yi, Jun-Jie Zou, Long Meng, Hou-Minji Chen, Zhong-Qiu Hong, Xiu-Fang Liu, Umar Farooq, Mo-Xian Chen, Zheng-Rong Lin, Wei Zhou, Li-Juan Ao, Xi-Quan Hu, Li-Li Niu

Ultrasound Stimulation of Prefrontal Cortex Improves Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice

Front Psychiatry.

doi: 10.3389/fpsyt.2022.864481.

(IF 2.849)

1350. Guizhu Feng, Lin Wei, Helong Che, Yan Shen, Kai Mi, Hui Bian, Hailong Yang, Jing Wu, Lixian Mu

Cathelicidin-NV from Nanorana ventripunctata effectively protects HaCaT cells, ameliorating ultraviolet B-induced skin photoaging

Peptides.

doi: 10.1016/j.peptides.2021.170712.

(IF 2.843)

1351. Yixin Yang, Hong Tang, Jiawen Zheng, Kai Yang

The PER1/HIF-1alpha negative feedback loop promotes ferroptosis and inhibits tumor progression in oral squamous cell carcinoma

Transl Oncol.

doi: 10.1016/j.tranon.2022.101360.

(IF 3.558)

1352. Yuting Gu, Yilan Shen, Wei Chen, Haidong He, Yulei Ma, Xiaobin Mei, Dianwen Ju, Hongrui Liu

Protective effects of interleukin-22 on oxalate-induced crystalline renal injury via alleviating mitochondrial damage and inflammatory response

Appl Microbiol Biotechnol.

doi: 10.1007/s00253-022-11876-4.

1353. Lin Tan, Weiming Qu, Dajun Wu, Minji Liu, Qiongjia Ai, Hongsai Hu, Qian Wang, Weishun Chen, Hongbing Zhou

The interferon regulatory factor 6 promotes cisplatin sensitivity in colorectal cancer

Bioengineered.

doi: 10.1080/21655979.2022.2062103.

(IF 2.205)

1354. Bo Wang, Yuyang Zhang, Shunmiao Fang, Hui Wang

Role of circRNA circ_0000080 in myocardial hypoxia injury

Bioengineered.

doi: 10.1080/21655979.2022.2066752.

(IF 2.205)

1355. Xuesong Yang, Guangyun Luo, Lan Fu, Hong Huang, Lifen Wang, Lihua Yin, Xuelian Zhang, Tingting Wang, Xuan Ma, Tianyu Feng, Jianzhou Ye

Intervention Mechanism of Hunag-Lian Jie-Du Decoction on Canonical Wnt/ β-Catenin Signaling Pathway in Psoriasis Mouse Model

Evid Based Complement Alternat Med.

doi: 10.1155/2022/3193572.

1356. Shali Yu, Zhijie Li, Qin Zhang, Rui Wang, Zixuan Zhao, Wenjie Ding, Fengxu Wang, Chuan Sun, Juan Tang, Xiaoke Wang, Hongbing Zhang, Rongrong Huang, Qiyun Wu, Junkang Jiang, Xinyuan Zhao

GPX4 degradation via chaperone-mediated autophagy contributes to antimony-triggered neuronal ferroptosis

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2022.113413.

1357. Shengqiang Pei, Chuansheng Xu, Jianqiu Pei, Ruifeng Bai, Rui Peng, Tiewei Li, Junjie Zhang, Xiangfeng Cong, Jerold Chun, Fang Wang, Xi Chen

Lysophosphatidic Acid Receptor 3 Suppress Neutrophil Extracellular Traps Production and Thrombosis During Sepsis

Front Immunol.

doi: 10.3389/fimmu.2022.844781.

(IF 5.085)

1358. Jieru Han, Wenhao Li, Guangyu Shi, Yunlei Huang, Xutao Sun, Na Sun, Deyou Jiang

Atractylenolide III Improves Mitochondrial Function and Protects Against Ulcerative Colitis by Activating AMPK/SIRT1/PGC-1 α

Mediators Inflamm.

doi: 10.1155/2022/9129984.

1359. Yingbin Lin, Xiaoman Dai, Jing Zhang, Xiaochun Chen

Metformin alleviates the depression-like behaviors of elderly apoE4 mice via improving glucose metabolism and mitochondrial biogenesis

Behav Brain Res.

doi: 10.1016/j.bbr.2022.113772.

(IF 2.977)

1360. Rui Yu, Mi Tian, Ping He, Jie Chen, Zixia Zhao, Yongzhe Zhang, Beiru Zhang

Suppression of LMCD1 ameliorates renal fibrosis by blocking the activation of ERK pathway

Biochim Biophys Acta Mol Cell Res.

doi: 10.1016/j.bbamcr.2021.119200.

1361. Hai-Liang Qi, Zheng-Yi Chen, Yu-Huan Qin, Ya-Zhai Li

Curcumin ameliorates H2O2-induced inflammatory response in chondrocytes by inducing autophagy activation

Exp Ther Med.

doi: 10.3892/etm.2022.11198.

(IF 1.785)

1362. Chong Zhang, Lin-Wen Wu, Zhi-Di Li, Man-Man Zhang, Jie Wu, Fei-Hua Du, Ling-Hui Zeng, Yang-Ling Li

DYRK1A suppression attenuates HIF‑1α accumulation and enhances the anti‑liver cancer effects of regorafenib and sorafenib under hypoxic conditions

Int J Oncol.

doi: 10.3892/ijo.2022.5335.

(IF 3.899)

1363. Huanhuan Wang, Yao Chen, Xudan Liu, Ruo Zhang, Xiaotong Wang, Qianhui Zhang, Yuting Wei, Fang Fang, Ye Yuan, Qianqian Zhou, Yinqiao Dong, Sainan Shi, Xiaojing Jiang, Xin Li

TNF-α derived from arsenite-induced microglia activation mediated neuronal necroptosis

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2022.113468.

1364. Dichao Hu, Lili Tian, Xueyun Li, Yirui Chen, Zheqing Xu, Ren-Shan Ge, Yiyan Wang

Tetramethyl bisphenol a inhibits leydig cell function in late puberty by inducing ferroptosis

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2022.113515.

1365. Yue Yang, Zhuangzhuang Jin, Jianghua Luo, Delong Zhang, Peng Shen, Dianbin Zheng, Donghao Liu, Lunhao Bai

Primary Repair for Treating Acute Proximal Anterior Cruciate Ligament Tears: A Histological Analysis and Prospective Clinical Trial

Front Bioeng Biotechnol.

doi: 10.3389/fbioe.2022.913900.

1366. Ming Xin, Qi Gao, Xindong Xiang, Juanjuan Xu, Yuhan Jiao, Xuan Li, Xianzhen Zhang, Xiuqin Jia

Autophagy Inhibition Enhances the Anti-Tumor Activity of Methylseleninic Acid in Cisplatin-Resistance Human Lung Adenocarcinoma Cells

Front Pharmacol.

doi: 10.3389/fphar.2022.890974.

(IF 4.225)

1367. Ting Geng, Yifan Sun, Lin Cheng, Yuming Cao, Ming Zhang, Zhidan Hong, Ling Ma, Yuanzhen Zhang

Downregulation of LHCGR Attenuates COX-2 Expression and Induces Luteinized Unruptured Follicle Syndrome in Endometriosis

Front Endocrinol (Lausanne).

doi: 10.3389/fendo.2022.853563.

1368. Haiheng Peng, Yifeng Yu, Huiyun Gu, Baiwen Qi, Aixi Yu

MicroRNA-483-5p inhibits osteogenic differentiation of human bone marrow mesenchymal stem cells by targeting the RPL31-mediated RAS/MEK/ERK signaling pathway

Cell Signal.

doi: 10.1016/j.cellsig.2022.110298.

(IF 3.968)

1369. Yue Zhuo, Shujun Li, Wei Hu, Yu Zhang, Yufan Shi, Faxue Zhang, Jian Zhang, Juan Wang, Meijuan Liao, Jiahao Chen, Huiling Qian, Dejia Li, Chengcao Sun

Targeting SNORA38B attenuates tumorigenesis and sensitizes immune checkpoint blockade in non-small cell lung cancer by remodeling the tumor microenvironment via regulation of GAB2/AKT/mTOR signaling p

J Immunother Cancer.

doi: 10.1136/jitc-2021-004113.

(IF 9.913)

1370. Changgui Wu, Shaohua Chen, Yang Liu, Bo Kong, Wei Yan, Tao Jiang, Hao Tian, Zhaoyi Liu, Qi Shi, Yongjun Wang, Qianqian Liang, Xiaobing Xi, Hao Xu

Cynarin suppresses gouty arthritis induced by monosodium urate crystals

Bioengineered.

doi: 10.1080/21655979.2022.2072055.

(IF 2.205)

1371. Qilai Cheng, Shanshan Zhang, Bing Zhong, Zhixi Chen, Fang Peng

Asiatic acid re-sensitizes multidrug-resistant A549/DDP cells to cisplatin by down regulating long non-coding RNA metastasis associated lung adenocarcinoma transcript 1/β-catenin signaling

Bioengineered.

doi: 10.1080/21655979.2022.2079302.

(IF 2.205)

1372. Zheng-Nan Ren, Jun Yang, Meng-Ya Zhang, Yi-Wen Huang, Dong-Xiao Song, Xun Sun, Li-Long Pan, Jia Sun

A novel resveratrol analog upregulates sirtuin 1 and inhibits inflammatory cell infiltration in acute pancreatitis

Acta Pharmacol Sin.

doi: 10.1038/s41401-021-00744-y.

(IF 5.064)

1373. Xiao Xu, Hao-Ran Shen, Min Yu, Mei-Rong Du, Xue-Lian Li

MicroRNA let-7i inhibits granulosa-luteal cell proliferation and oestradiol biosynthesis by directly targeting IMP2

Reprod Biomed Online.

doi: 10.1016/j.rbmo.2022.01.016.

(IF 3.218)

1374. Manyun Dai, Wan Peng, Ting Zhang, Qi Zhao, Xiaofang Ma, Yan Cheng, Chunyan Wang, Fei Li

Metabolomics reveals the role of PPARα in Tripterygium Wilfordii-induced liver injury

J Ethnopharmacol.

doi: 10.1016/j.jep.2022.115090.

(IF 3.69)

1375. Xusheng Zhang, Mengting Wang, Bingyan Feng, Qiuyu Zhang, Jia Tong, Mingyong Wang, Chengbiao Lu, Shiyong Peng

Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia

Int J Mol Sci.

doi: 10.3390/ijms23105586.

(IF 4.556)

1376. Yudan Gong, Xinze Li, Liuyi Xie

Circ_0001897 regulates high glucose-induced angiogenesis and inflammation in retinal microvascular endothelial cells through miR-29c-3p/transforming growth factor beta 2 axis

Bioengineered.

doi: 10.1080/21655979.2022.2070997.

(IF 2.205)

1377. Jia-Hui Sun, Ming Huang, Zhou Fang, Tian-Xiao Li, Ting-Ting Wu, Yi Chen, Da-Ping Quan, Ying-Ying Xu, Yu-Ming Wang, Yi Yang, Jian-Long Zou

Nerve bundle formation during the promotion of peripheral nerve regeneration: collagen VI-neural cell adhesion molecule 1 interaction

Neural Regen Res.

doi: 10.4103/1673-5374.324861.

(IF 3.171)

1378. Huixing Zhou, Fulei Zhang, Yahan Wu, Hongyu Liu, Ran Duan, Yuanyuan Liu, Yan Wang, Xiaoyu He, Yuemei Zhang, Xiue Ma, Yi Guan, Yi Liu, Dandan Liang, Liping Zhou, Yi-Han Chen

LRP5 regulates cardiomyocyte proliferation and neonatal heart regeneration by the AKT/P21 pathway

J Cell Mol Med.

doi: 10.1111/jcmm.17311.

(IF 4.486)

1379. Qingyong Li, Jun Peng, Yuelian Luo, Jiaxin Zhou, Tailin Li, Lin Cao, Shuling Peng, Zhiyi Zuo, Zhi Wang

Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer's disease-like mice

J Neuroinflammation.

doi: 10.1186/s12974-022-02521-y.

1380. Junfeng Yan, Xia Zhang, Caixian Xiao, Junlu Yi, Qian Chen, Tingliang Gong, Xin Xie, Wenqiang Tao

Effect of Yisui Multipurpose Soup's Amelioration on D-Galactose-Induced Neuronal Cells

Evid Based Complement Alternat Med.

doi: 10.1155/2022/3372350.

1381. Xia Li, Shuyi Qian, Feng Huang, Kaimin Li, Yu Song, Jiqian Liu, Yujie Guo, Chunhui Zhang, Christophe Blecker

The Investigation of Protein Profile and Meat Quality in Bovine Longissimus thoracic Frozen under Different Temperatures by Data-Independent Acquisition (DIA) Strategy

Foods.

doi: 10.3390/foods11121791.

(IF 4.092)

1382. Yongfang Zhang, Yan Gao, Fan Yang, Xiuying Wu, Zhiyin Tang, Hongtao Liu

Neuroglobin alleviates the neurotoxicity of sevoflurane to fetal rats by inhibiting neuroinflammation and affecting microglial polarization

Brain Res Bull.

doi: 10.1016/j.brainresbull.2022.03.006.

(IF 3.37)

1383. Yanhui Cui, Xueqin Wang, Fengyu Lin, Wen Li, Yuhao Zhao, Fei Zhu, Hang Yang, Mingjun Rao, Yi Li, Huaying Liang, Minhui Dai, Ben Liu, Lingli Chen, Duoduo Han, Rongli Lu, Wenzhong Peng, Yan Zhang, Chao Song, Yanwei Luo, Pinhua Pan

MiR-29a-3p Improves Acute Lung Injury by Reducing Alveolar Epithelial Cell PANoptosis

Aging Dis.

doi: 10.14336/AD.2021.1023.

(IF 5.402)

1384. Shunyun Xie, Feng Xu, Yue Lu, Yixian Zhang, Xinyang Li, Mengyuan Yu, Wenpeng Cui

Elabela Attenuates the TGF-β1-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells in Patients Receiving Peritoneal Dialysis

Front Pharmacol.

doi: 10.3389/fphar.2022.890881.

(IF 4.225)

1385. Xuqing Cao, Xiaojin La, Biwei Zhang, Zhigang Wang, Yinghong Li, Yanping Bo, Hong Chang, Xiujuan Gao, Chunyu Tian, Chenxi Wu, Ji-An Li

Sanghuang Tongxie Formula Ameliorates Insulin Resistance in Drosophila Through Regulating PI3K/Akt Signaling

Front Pharmacol.

doi: 10.3389/fphar.2022.874180.

(IF 4.225)

1386. Jin Qiu, Qianqian Fan, Sainan Xu, Dongmei Wang, Juntong Chen, Sainan Wang, Tianhui Hu, Xinran Ma, Yiyun Cheng, Lingyan Xu

A fluorinated peptide with high serum- and lipid-tolerence for the delivery of siRNA drugs to treat obesity and metabolic dysfunction

Biomaterials.

doi: 10.1016/j.biomaterials.2022.121541.

(IF 10.317)

1387. Yan Zhang, Dandan Xu, Youjun Zhang, Qingjun Wu, Wen Xie, Zhaojiang Guo, Shaoli Wang

Frequencies and mechanisms of pesticide resistance in Tetranychus urticae field populations in China

Insect Sci.

doi: 10.1111/1744-7917.12957.

(IF 2.791)

1388. Yuhuan Cui, Meihong Liu, Li Zuo, Haiyan Wang, Jian Liu

Fraxetin protects rat brains from the cerebral stroke via promoting angiogenesis and activating PI3K/Akt pathway

Immunopharmacol Immunotoxicol.

doi: 10.1080/08923973.2022.2052893.

1389. Nan Huang, Yaxun Wei, Yi Cheng, Xiaolong Wang, Qi Wang, Dong Chen, Wenjing Li

Iron metabolism protein transferrin receptor 1 involves in cervical cancer progression by affecting gene expression and alternative splicing in HeLa cells

Genes Genomics.

doi: 10.1007/s13258-021-01205-w.

1390. Jinhui Bai, Hongyan Xu, Jiachen Fang, Congcong Zhang, Jixuan Song, Xinxin Zhang, Beibei Hao, Baozhen Yin, Guangjun Xia

miR-15a regulates the preadipocyte differentiation by targeting ABAT gene in Yanbian yellow cattle

Anim Biotechnol.

doi: 10.1080/10495398.2022.2088552.

(IF 1.487)

1391. Zhuo-Na Han, Xiao-Xue Lin, Yue-Ying Wang, Ran Ding, Lan Hong, Xun Cui

Cholecystokinin Octapeptide Promotes ANP Secretion through Activation of NOX4-PGC-1 α-PPAR α/PPAR γ Signaling in Isolated Beating Rat Atria

Oxid Med Cell Longev.

doi: 10.1155/2022/5905374.

(IF 5.076)

1392. Kai Xu, Xiang Liu, Bin Wen, Yazhou Liu, Wei Zhang, Xiaolin Hu, Ling Chen, Weijian Hang, Juan Chen

GSK-J4, a Specific Histone Lysine Demethylase 6A Inhibitor, Ameliorates Lipotoxicity to Cardiomyocytes via Preserving H3K27 Methylation and Reducing Ferroptosis

Front Cardiovasc Med.

doi: 10.3389/fcvm.2022.907747.

1393. Yong Fang, Jun Yin, Yaxing Shen, Hao Wang, Han Tang, Xiaosang Chen

CircCDR1 sponges miR-1290 to regulate cell proliferation, migration, invasion, and apoptosis in esophageal squamous cell cancer

Cell Cycle.

doi: 10.1080/15384101.2022.2050645.

(IF 3.699)

1394. Changwei Li, Minglong Qiu, Leilei Chang, Jin Qi, Lianfang Zhang, Bernhard Ryffel, Lianfu Deng

The osteoprotective role of USP26 in coordinating bone formation and resorption

Cell Death Differ.

doi: 10.1038/s41418-021-00904-x.

(IF 10.717)

1395. Gang Zhang, Song-Lin Liu, Wen-Ting Yi, Yu-Ping Dong, Yin-Xu Wan

Long noncoding RNA ZFPM2-AS1 regulates renal cell carcinoma progression via miR-130a-3p/ESCO2

Kaohsiung J Med Sci.

doi: 10.1002/kjm2.12527.

(IF 1.737)

1396. Qiuping Guo, Lingyu Zhang, Yunju Yin, Saiming Gong, Yuhuan Yang, Sisi Chen, Mengmeng Han, Yehui Duan

Taurine Attenuates Oxidized Fish Oil-Induced Oxidative Stress and Lipid Metabolism Disorder in Mice

Antioxidants (Basel).

doi: 10.3390/antiox11071391.

1397. Haijun Cai, Hui Guo, Yixuan Deng, Jinhai Jiang, Siyuan Liu, Wenge He, Huagang Jian

RRM2 regulates osteogenesis of mouse embryo fibroblasts via the Wnt/β‑catenin signaling pathway

Exp Ther Med.

doi: 10.3892/etm.2022.11542.

(IF 1.785)

1398. Danjun Wang, Jianying Zhang, Linhan Cai, Xiaofeng Dai

Cold Atmospheric Plasma Conveys Selectivity Against Hepatocellular Carcinoma Cells via Triggering EGFR(Tyr1068)-Mediated Autophagy

Front Oncol.

doi: 10.3389/fonc.2022.895106.

(IF 4.848)

1399. Wan Wang, Tianqing Yan, Xinjian Guo, Heng Cai, Chang Liang, Linyan Huang, Yanling Wang, Ping Ma, Suhua Qi

KAP1 phosphorylation promotes the survival of neural stem cells after ischemia/reperfusion by maintaining the stability of PCNA

Stem Cell Res Ther.

doi: 10.1186/s13287-022-02962-5.

(IF 5.116)

1400. Zhi-Bin Ke, Qi You, Jia-Yin Chen, Jiang-Bo Sun, Yu-Ting Xue, Rui-Bin Zhuang, Qing-Shui Zheng, Ye-Hui Chen, Yong Wei, Xiong-Lin Sun, Xue-Yi Xue, Ning Xu

A radiation resistance related index for biochemical recurrence and tumor immune environment in prostate cancer patients

Comput Biol Med.

doi: 10.1016/j.compbiomed.2022.105711.

(IF 3.434)

1401. Zhuangzhuang Jin, Bohan Chang, Yingliang Wei, Yue Yang, He Zhang, Jiabao Liu, Longhuan Piao, Lunhao Bai

Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK/PINK1/Parkin-mediated mitophagy

Biomed Pharmacother.

doi: 10.1016/j.biopha.2022.113092.

(IF 4.545)

1402. Xianxiang Chen, Mingyue Shen, Jun Yang, Qiang Yu, Yi Chen, Xin Wang, Hanyu Lu, Xin Tao, Haizhen Li, Jianhua Xie

RNA-seq based elucidation of mechanism underlying Mesona chinensis Benth polysaccharide protected H2O2-induced oxidative damage in L02 cells

Food Res Int.

doi: 10.1016/j.foodres.2022.111383.

(IF 4.972)

1403. Jinghui Zhang, Nana Qiao, Jiwen Wang, Baomin Li

Nuclear translocation of GluA2/ GAPDH promotes neurotoxicity after pilocarpine-induced epilepsy

Epilepsy Res.

doi: 10.1016/j.eplepsyres.2022.106945.

(IF 2.208)

1404. Lu Zheng, Yi Wang, Bin Shao, Huijuan Zhou, Xing Li, Cai Zhang, Ning Sun, Jing Shi

Multiple Mild Stimulations Reduce Membrane Distribution of CX3CR1 Promoted by Annexin a1 in Microglia to Attenuate Excessive Dendritic Spine Pruning and Cognitive Deficits Caused by a Transient Ischem

Neurosci Bull.

doi: 10.1007/s12264-022-00847-4.

(IF 4.326)

1405. Xiaoxue Lu, Qiaolin Xu, Yanan Tong, Zhujun Zhang, Guodong Dun, Yuyang Feng, Jie Tang, Dan Han, Yilan Mao, Ling Deng, Xiaoyi He, Qian Li, Yang Xiang, FengChao Wang, Dongzhu Zeng, Bin Tang, Xuhu Mao

Long non-coding RNA EVADR induced by Fusobacterium nucleatum infection promotes colorectal cancer metastasis

Cell Rep.

doi: 10.1016/j.celrep.2022.111127.

(IF 8.109)

1406. Fengqi Qiu, Qi Yang, Wenjia Sun, Kexin Ruan, Nan Jiang, Jianya Zhou

EZH2 inhibition activates dsRNA-interferon axis stress and promotes response to PD-1 checkpoint blockade in NSCLC

J Cancer.

doi: 10.7150/jca.73291.

(IF 3.565)

1407. Cong Chen, Shuhong Liu, Gaozhen Cao, Yang Hu, Run Wang, Min Wu, Mingya Liu, Kai Hang Yiu

Cardioprotective Effect of Paeonol on Chronic Heart Failure Induced by Doxorubicin via Regulating the miR-21-5p/S-Phase Kinase-Associated Protein 2 Axis

Front Cardiovasc Med.

doi: 10.3389/fcvm.2022.695004.

1408. Fangfang Hu, Yan Ren, Zunyun Wang, Hui Zhou, Yumei Luo, Minghua Wang, Faqing Tian, Jian Zheng, Juan Du, Gang Pang

Bioinformatics analysis of KLF2 as a potential prognostic factor in ccRCC and association with epithelial-mesenchymal transition

Exp Ther Med.

doi: 10.3892/etm.2022.11498.

(IF 1.785)

1409. Hai-Juan Bao, Xi Chen, Xin Liu, Wu Wu, Qian-Hui Li, Jing-Yuan Xian, Yang Zhao, Shuo Chen

Box C/D snoRNA SNORD89 influences the occurrence and development of endometrial cancer through 2'-O-methylation modification of Bim

Cell Death Discov.

doi: 10.1038/s41420-022-01102-5.

1410. Yong Zeng, Rui He, Yong Liu, Ting Luo, Qing Li, Yu He, Miao Fang, Taiping Wang

HDAC1 regulates inflammation and osteogenic differentiation of ankylosing spondylitis fibroblasts through the Wnt-Smad signaling pathway

J Orthop Surg Res.

doi: 10.1186/s13018-022-03224-z.

(IF 1.777)

1411. Chunyue Liu, Zixing Fu, Shanshan Wu, Xiaosong Wang, Shengrong Zhang, Chu Chu, Yuan Hong, Wenbo Wu, Shengqi Chen, Yueqing Jiang, Yang Wu, Yongbo Song, Yan Liu, Xing Guo

Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease

EMBO Mol Med.

doi: 10.15252/emmm.202215851.

(IF 8.821)

1412. Yuanzheng Lu, Chenyu Zhang, Jie Chen, Qiuping Zou, Bo Li, Hongyan Wei, Mary P Chang, Xiaoxing Liao, Chunlin Hu

Hypothermia preconditioning improves cardiac contractility after cardiopulmonary resuscitation through AMPK-activated mitophagy

Exp Biol Med (Maywood).

doi: 10.1177/15353702221081546.

1413. Xiuchen Xuan, Peizhu Tan, Ximei Zhang, Hui Huang, Yanze Li, Yu Jiang, Aimiao Yu, Yuanyuan Zhao, Kuo Wang, Baozhu Tang, Shuye Qu, Yunyan Jiang, Jiaran Xu, Xu Gao, Lingyun Zhou

Long-term low-dose alcohol intake promotes white adipose tissue browning and reduces obesity in mice

Food Funct.

doi: 10.1039/d2fo00743f.

(IF 4.171)

1414. Di Zhu, Chenglin Jia, Tongkai Cai, Jiacheng Li, Xia Feng, Nan Chen, Cheng Zhao, Yuzhen Wang, Yongbing Cao, Yemin Cao

Ruan Jian Qing Mai Recipe Inhibits the Inflammatory Response in Acute Lower Limb Ischemic Mice through the JAK2/STAT3 Pathway

Evid Based Complement Alternat Med.

doi: 10.1155/2022/2481022.

1415. Qian Ren, Caixia Yi, Jun Pan, Xin Sun, Xiao Huang

Smart Fe3O4@ZnO Core-Shell Nanophotosensitizers Potential for Combined Chemo and Photodynamic Skin Cancer Therapy Controlled by UVA Radiation

Int J Nanomedicine.

doi: 10.2147/IJN.S372377.

1416. Yaqing Li, Chujie Qu, Hao Song, Tian Li, Jiaxin Zheng, Liyang Wu, Nao Yan, Linling Xu, Changhua Qu, Junjian Zhang

Enriched environment priors to TET1 hippocampal administration for regulating psychiatric behaviors via glial reactivity in chronic cerebral hypoperfusion models

J Affect Disord.

doi: 10.1016/j.jad.2022.04.087.

1417. Xiuqin Jia, Ming Xin, Juanjuan Xu, Xindong Xiang, Xuan Li, Yuhan Jiao, Lulin Wang, Jingjing Jiang, Feng Pang, Xianzhen Zhang, Jian Zhang

Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma

Cell Death Dis.

doi: 10.1038/s41419-022-05201-0.

(IF 6.304)

1418. Beibei Zhang, Jing Li, Xianlong Zong, Jianling Wang, Lianlian Xin, Haiyao Song, Wenxue Zhang, Stephane Koda, Hui Hua, Bo Zhang, Qian Yu, Kui-Yang Zheng, Chao Yan

FXR deficiency in hepatocytes disrupts the bile acid homeostasis and inhibits autophagy to promote liver injury in Schistosoma japonicum-infected mice

PLoS Negl Trop Dis.

doi: 10.1371/journal.pntd.0010651.

1419. Yanli Li, Shilian Tan, Yuanying Shen, Le Guo

miR‑146a‑5p negatively regulates the IL‑1β‑stimulated inflammatory response via downregulation of the IRAK1/TRAF6 signaling pathway in human intestinal epithelial cells

Exp Ther Med.

doi: 10.3892/etm.2022.11552.

(IF 1.785)

1420. Xiaojin Liu, Hao Lv, Haibin Shen

Vitamin D enhances the sensitivity of breast cancer cells to the combination therapy of photodynamic therapy and paclitaxel

Tissue Cell.

doi: 10.1016/j.tice.2022.101815.

(IF 1.837)

1421. Dan Qin, Shenghui Liu, Yuanyuan Lu, Yi Yan, Jing Zhang, Shiyao Cao, Mi Chen, Ning Chen, Wendong Huang, Liqiang Wang, Xiangmei Chen, Lisheng Zhang

Lgr5 + cell fate regulation by coordination of metabolic nuclear receptors during liver repair

Theranostics.

doi: 10.7150/thno.74194.

(IF 8.579)

1422. Shenghang Wang, Ting Huyan, Chenge Lou, Peng Shang, Hao Zhang

12 T high static magnetic field suppresses osteosarcoma cells proliferation by regulating intracellular ROS and iron status

Exp Cell Res.

doi: 10.1016/j.yexcr.2022.113223.

(IF 3.383)

1423. Ying He, Yang Zhang, Junli Zhang, Xiaoyu Hu

The Key Molecular Mechanisms of Sini Decoction Plus Ginseng Soup to Rescue Acute Liver Failure: Regulating PPARα to Reduce Hepatocyte Necroptosis?

J Inflamm Res.

doi: 10.2147/JIR.S373903.

1424. Lu Li, Pishun Li, Jiale Chen, Li Li, Yunfan Shen, Yangzixuan Zhu, Jiayi Liu, Lu Lv, Song Mao, Fang Chen, Guang Hu, Kai Yuan

Rif1 interacts with non-canonical polycomb repressive complex PRC1.6 to regulate mouse embryonic stem cells fate potential

Cell Regen.

doi: 10.1186/s13619-022-00124-9.

1425. Su-Fang Kuang, Xia Li, Ding-Yun Feng, Wen-Bin Wu, Hui Li, Bo Peng, Xuan-Xian Peng, Zhuang-Gui Chen, Tian-Tuo Zhang

Nitrite Promotes ROS Production to Potentiate Cefoperazone-Sulbactam-Mediated Elimination to Lab-Evolved and Clinical-Evolved Pseudomonas aeruginosa

Microbiol Spectr.

doi: 10.1128/spectrum.02327-21.

(IF 5.465)

1426. Shishuai Meng, Kai Kang, Dongsheng Fei, Songlin Yang, Shangha Pan, Kaijiang Yu, Mingyan Zhao

MicroRNA-363-3p/sphingosine-1-phosphate receptor 1 axis inhibits sepsis-induced acute lung injury via the inactivation of nuclear factor kappa-B ligand signaling

Exp Anim.

doi: 10.1538/expanim.21-0160.

1427. Lan Zhou, Shupei Tang, Fang Li, Yonghui Wu, Sirui Li, Liwei Cui, Jing Luo, Lu Yang, Zhicheng Ren, Ji Zhang, Denglu Zhou, Jun Jiang, Xiaochao Yang, Xinyuan Zhou, Yuzhang Wu

Ceria nanoparticles prophylactic used for renal ischemia-reperfusion injury treatment by attenuating oxidative stress and inflammatory response

Biomaterials.

doi: 10.1016/j.biomaterials.2022.121686.

(IF 10.317)

1428. Ruyi Yang, Fazhang Chen, Haizhen Xu, Zhanfang Guo, Changxia Cao, Hongyan Zhang, Changrong Zhang

Exploring the Mechanism of Realgar against Esophageal Cancer Based on Ferroptosis Induced by ROS-ASK1-p38 MAPK Signaling Pathway

Evid Based Complement Alternat Med.

doi: 10.1155/2022/3698772.

1429. Qiu Tu, Xiuyun Liu, Xiaoqing Yao, Ruixue Li, Gaojing Liu, Honglv Jiang, Kaiqin Li, Qiongfang Chen, Xiaoyan Huang, Qing Chang, Guoqiang Xu, Hong Zhu, Peng Shi, Bo Zhao

RETSAT associates with DDX39B to promote fork restarting and resistance to gemcitabine based chemotherapy in pancreatic ductal adenocarcinoma

J Exp Clin Cancer Res.

doi: 10.1186/s13046-022-02490-3.

1430. Juan Wang, Guo-Dong Dai

Comparative Effects of Brominated Flame Retardants BDE-209, TBBPA, and HBCD on Neurotoxicity in Mice

Chem Res Toxicol.

doi: 10.1021/acs.chemrestox.2c00126.

(IF 3.184)

1431. Kepeng Ou, Youjian Li, Yiling Long, Yafei Luo, Dianyong Tang, Zhongzhu Chen

Inhibition of MORC2 Mediates HDAC4 to Promote Cellular Senescence through p53/p21 Signaling Axis

Molecules.

doi: 10.3390/molecules27196247.

(IF 3.267)

1432. Ye Tian, Gang Xu, Hong Gao, Hong-Yan Xie, Yu-Lin Leng, Xiao-Xu Fu, Chun-Guang Xie

The Mitigatory Effect of Shen-Qi Compound on the Diabetic Thoracic Aortic Complications through Inhibiting the Inflammatory Microenvironment by miR-223-3p/RBP-J/IRF8 Axis

Evid Based Complement Alternat Med.

doi: 10.1155/2022/6686931.

1433. Chengzhao Li, Jun Dang, Yue Lv, Yan Fang, Chengjun Ma, Qilan Wang, Gang Li

The Isolation and Preparation of Samwinol from Dracocephalum heterophyllum and Prevention on Aβ25-35-Induced Neuroinflammation in PC-12 Cells

Int J Mol Sci.

doi: 10.3390/ijms231911572.

(IF 4.556)

1434. Huige Zhang, Zixi Gao, Fei He, Jingfeng Lan, Hailong Chai, Shiqian Zhang, Xianwei Zuo, Hongli Chen, Xingguo Chen

Generation of 3'-OH terminal-triggered encoding of multicolor fluorescence for simultaneous detection of different DNA glycosylases

Anal Bioanal Chem.

doi: 10.1007/s00216-022-04267-1.

(IF 3.637)

1435. Wen Zhang, Jingwen Liu, Yiming Li, Fujiang Guo

A bavachinin analog, D36, induces cell death by targeting both autophagy and apoptosis pathway in acute myeloid leukemia cells

Cancer Chemother Pharmacol.

doi: 10.1007/s00280-022-04462-y.

1436. Shuo Chen, Danyuan Huang, Li Zhu, Yukun Jiang, Yuzhe Guan, Shujuan Zou, Yuyu Li

Contribution of diabetes mellitus to periodontal inflammation during orthodontic tooth movement

Oral Dis.

doi: 10.1111/odi.14365.

(IF 2.613)

1437. Jing Zuo, Tian-Hao Zhang, Liang Xiong, Lu Huang, Cheng Peng, Qin-Mei Zhou, Ou Dai

Two Pairs of 7,7'-Cyclolignan Enantiomers with Anti-Inflammatory Activities from Perilla frutescens

Molecules.

doi: 10.3390/molecules27186102.

(IF 3.267)

1438. Yin Tang, Ke Wei, Ling Liu, Jingyue Ma, Siqi Wu, Wenjing Tang

Activation of PPAR γ Protects Obese Mice from Acute Lung Injury by Inhibiting Endoplasmic Reticulum Stress and Promoting Mitochondrial Biogenesis

PPAR Res.

doi: 10.1155/2022/7888937.

(IF 2.953)

1439. Na Qu, Ruizhe Wang, Yiming Meng, Ning Liu, Jingbo Zhai, Fengping Shan

Methionine enkephalin inhibited cervical carcinoma via apoptosis promotion and reduction of myeloid derived suppressor cell infiltrated in tumor

Int Immunopharmacol.

doi: 10.1016/j.intimp.2022.108933.

(IF 3.943)

1440. Xinxin Shao, Shenghua Zhan, Qiuying Quan, Yu Shen, Siji Chen, Xueguang Zhang, Rui Li, Mi Liu, Lei Cao

Clinical significance of B7-H3 and HER2 co-expression and therapeutic value of combination treatment in gastric cancer

Int Immunopharmacol.

doi: 10.1016/j.intimp.2022.108988.

(IF 3.943)

1441. Shilin Yin, Zhiwei Zhang, Hong Tang, Kai Yang

The biological clock gene PER1 affects the development of oral squamous cell carcinoma by altering the circadian rhythms of cell proliferation and apoptosis

Chronobiol Int.

doi: 10.1080/07420528.2022.2082302.

(IF 2.486)

1442. Lin Cai, Ze-Rui Wu, Lei Cao, Jia-Dong Xu, Jiang-Long Lu, Cheng-de Wang, Jing-Hao Jin, Zhe-Bao Wu, Zhi-Peng Su

ACT001 inhibits pituitary tumor growth by inducing autophagic cell death via MEK4/MAPK pathway

Acta Pharmacol Sin.

doi: 10.1038/s41401-021-00856-5.

(IF 5.064)

1443. Kailing Pan, Bin Hu, Lude Wang, Jianlie Yuan, Wenxia Xu

STUB1-SMYD2 Axis Regulates Drug Resistance in Glioma cells

J Mol Neurosci.

doi: 10.1007/s12031-022-02051-5.

(IF 2.678)

1444. Hang Zeng, Chenxi Tang, Bingru Lin, Mengli Yu, Xinyu Wang, Jinghua Wang, Shenghui Chen, Chaohui Yu

The regulation effect of GLUT9/SLC2A9 on intrahepatic uric acid level and metabolic associated fatty liver disease

Hepatol Int.

doi: 10.1007/s12072-022-10371-2.

(IF 5.102)

1445. Min-Hua Cui, Lei Chen, Qian Zhang, Lan-Ying Liu, Hui Pan, He Liu, Ai-Jie Wang

Understanding the effects of sludge characteristics on the biosorption of triclosan

Sci Total Environ.

doi: 10.1016/j.scitotenv.2022.156665.

(IF 6.551)

1446. Tian Xiao, Liping Yang, Pu Chen, Xiaohua Duan

Para‑hydroxybenzaldehyde against transient focal cerebral ischemia in rats via mitochondrial preservation

Exp Ther Med.

doi: 10.3892/etm.2022.11652.

(IF 1.785)

1447. Jiexin Zhang, Caiwen Ou, Minsheng Chen

Curcumin attenuates cadmium-induced atherosclerosis by regulating trimethylamine-N-oxide synthesis and macrophage polarization through remodeling the gut microbiota

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2022.114057.

1448. Fangwei Yang, Yixuan Li, Yunfei Xie, Weirong Yao, Fazheng Ren

Diethyl phosphate disrupts hypothalamus-pituitary-adrenal axis endocrine hormones via nuclear receptors GR and Nur77: Integration of evidences from in vivo, in vitro and in silico approaches

Sci Total Environ.

doi: 10.1016/j.scitotenv.2022.157015.

(IF 6.551)

1449. Sihui Li, Xing Luo, Zhangbin Liao, Mengqing Liang, Houguo Xu, Kangsen Mai, Yanjiao Zhang

Effects of Lysophosphatidylcholine on Intestinal Health of Turbot Fed High-Lipid Diets

Nutrients.

doi: 10.3390/nu14204398.

(IF 4.546)

1450. Zhongye Jiang, Jianmin Cao, Hao Su, Hui Cao, Zeyuan Sun, Haoze Jiang, Yanjun Fan

Exercise serum regulates uric acid transporters in normal rat kidney cells

Sci Rep.

doi: 10.1038/s41598-022-22570-w.

1451. Qian Wang, Han-Yang Li, Zhuo-Min Ling, Gang Chen, Zhong-Ya Wei

Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses

J Neuroinflammation.

doi: 10.1186/s12974-022-02603-x.

1452. Xiaobo Zhang, Rui Gao, Zhen Zhou, Jiayi Sun, Xuehua Tang, Jialiang Li, Xin Zhou, Tao Shen

Uncovering the mechanism of Huanglian-Wuzhuyu herb pair in treating nonalcoholic steatohepatitis based on network pharmacology and experimental validation

J Ethnopharmacol.

doi: 10.1016/j.jep.2022.115405.

(IF 3.69)

1453. Jianqing Zhang, Xiaoxia Yan, Qinghao Jin, Jing Chen, Lin Yang, Wenlong Wei, Hua Qu, Changliang Yao, Jinjun Hou, Likun Gong, Wanying Wu, De-An Guo

Novel triterpenoids from Alisma plantago-aquatica with influence on LDL uptake in HepG2 cells by inhibiting PCSK9

Phytomedicine.

doi: 10.1016/j.phymed.2022.154342.

(IF 4.268)

1454. Yan-Mei Zhang, Khas Erdene, Ya-Bo Zhao, Chang-Qing Li, Li Wang, Feng Tian, Chang-Jin Ao, Hai Jin

Role of white adipose tissue browning in cold seasonal acclimation in grazing Mongolian sheep (Ovisaries)

J Therm Biol.

doi: 10.1016/j.jtherbio.2022.103333.

(IF 2.361)

1455. Shuying Dai, Yi Liu, Fangmin Zhao, Haibing Wang, Tianyu Shao, Zeting Xu, Liumei Shou, Shuyi Chen, Gao-Chen-Xi Zhang, Qijin Shu

Aqueous extract of Taxus chinensis var. mairei targeting CD47 enhanced antitumor effects in non-small cell lung cancer

Biomed Pharmacother.

doi: 10.1016/j.biopha.2022.113628.

(IF 4.545)

1456. Shaowei Wang, Bingru Zhang, Yingna Zhai, Yunbing Tang, Yuzhen Lou, Yang Zhu, Yiyan Wang, Ren-Shan Ge, Huitao Li

Structure-activity relationship analysis of perfluoroalkyl carbonic acids on human and rat placental 3β-hydroxysteroid dehydrogenase activity

Toxicology.

doi: 10.1016/j.tox.2022.153334.

(IF 4.099)

1457. Kou Liu, Xiang Gao, Chengyang Hu, Yanchao Gui, Siyu Gui, Qinyu Ni, Liming Tao, Zhengxuan Jiang

Capsaicin ameliorates diabetic retinopathy by inhibiting poldip2-induced oxidative stress

Redox Biol.

doi: 10.1016/j.redox.2022.102460.

(IF 9.986)

1458. Jie Man, Hongsheng Wang, Xiaowen Qian, Lian Chen, Yangyang Ma, Maoxiang Qian, Xiaowen Zhai

TCF3 protein was highly expressed in pediatric Burkitt lymphoma and predicts poor prognosis: a single-center study

Leuk Lymphoma.

doi: 10.1080/10428194.2022.2076852.

1459. Lifang Ye, Jieqiong Song, Yijun Zheng, Ming Zhong, Jun Liu, Duming Zhu, Shuling Hu

New mechanism for mesenchymal stem cell microvesicle to restore lung permeability: intracellular S1P signaling pathway independent of S1P receptor-1

Stem Cell Res Ther.

doi: 10.1186/s13287-022-03177-4.

(IF 5.116)

1460. Gang Rui, Li-Yuan Liu, Ling Guo, Yi-Zhe Xue, Pan-Pan Lai, Peng Gao, Jun-Ling Xing, Jing Li, Gui-Rong Ding

Effects of 5.8 GHz microwave on hippocampal synaptic plasticity of rats

Int J Environ Health Res.

doi: 10.1080/09603123.2021.1952165.

1461. Qian Hu, Jiaqi Yao, Xiajia Wu, Juan Li, Guixiang Li, Wenfu Tang, Jingping Liu, Meihua Wan

Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation

Acta Pharm Sin B.

doi: 10.1016/j.apsb.2021.10.008.

(IF 7.097)

1462. Wei Zhou, Wen-Hui Wu, Zi-Lin Si, Hui-Ling Liu, Hanyu Wang, Hong Jiang, Ya-Fang Liu, Raphael N Alolga, Cheng Chen, Shi-Jia Liu, Xue-Yan Bian, Jin-Jun Shan, Jing Li, Ning-Hua Tan, Zhi-Hao Zhang

The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice

Nat Commun.

doi: 10.1038/s41467-022-33824-6.

(IF 12.121)

1463. Chuanli Hou, Wangqian Sha, Yujuan Li, Maojin Yao, Jiaoyan Ren

A modified xanthine oxidase cell model for screening of antihyperuricemic functional compounds

Food Funct.

doi: 10.1039/d2fo00297c.

(IF 4.171)

1464. Yanting Yu, Zhiyun Ren, Anni Xie, Yutao Jia, Ying Xue, Ping Wang, Daxi Ji, Xiaoyan Wang

Assessment of Urinary Exosomal NHE3 as a Biomarker of Acute Kidney Injury

Diagnostics (Basel).

doi: 10.3390/diagnostics12112634.

1465. Shunchi Zhang, Yanrou Bei, Yueling Huang, Yimin Huang, Lianjie Hou, Xi-Long Zheng, Yiming Xu, Shaoguo Wu, Xiaoyan Dai

Induction of ferroptosis promotes vascular smooth muscle cell phenotypic switching and aggravates neointimal hyperplasia in mice

Mol Med.

doi: 10.1186/s10020-022-00549-7.

(IF 4.096)

1466. Wei-Xiao Niu, Yun-Yang Bao, Na Zhang, Zhen-Ning Lu, Mao-Xu Ge, Yi-Ming Li, Yi Li, Ming-Hua Chen, Hong-Wei He

Dehydromevalonolactone ameliorates liver fibrosis and inflammation by repressing activation of NLRP3 inflammasome

Bioorg Chem.

doi: 10.1016/j.bioorg.2022.105971.

(IF 4.831)

1467. Heng Sun, Wenjie Han, Juyi Wen, Xue Ma

IL4I1 and tryptophan metabolites enhance AHR signals to facilitate colorectal cancer progression and immunosuppression

Am J Transl Res.

(IF 3.375)

1468. Dan Zhang, Ying Su, Peng Sun, Xingzhi Liu, Lin Zhang, Xuwei Ling, Yuhui Fan, Kang Wu, Qin Shi, Jisheng Liu

A TGF-loading hydrogel scaffold capable of promoting chondrogenic differentiation for repairing rabbit nasal septum cartilage defect

Front Bioeng Biotechnol.

doi: 10.3389/fbioe.2022.1057904.

1469. Lingdi Nie, Kai Sun, Ziyang Gong, Haoyang Li, John P Quinn, Minyan Wang

Src Family Kinases Facilitate the Crosstalk between CGRP and Cytokines in Sensitizing Trigeminal Ganglion via Transmitting CGRP Receptor/PKA Pathway

Cells.

doi: 10.3390/cells11213498.

(IF 4.366)

1470. Ying Du, Gang Geng, Chunquan Zhao, Tian Gao, Bin Wei

LncRNA MEG3 promotes cisplatin sensitivity of cervical cancer cells by regulating the miR-21/PTEN axis

BMC Cancer.

doi: 10.1186/s12885-022-10188-0.

(IF 3.15)

1471. Qi Hao, Lulu Wang, Minghui Zhang, Zhe Wang, Meng Li, Xuejun Gao

Taurine stimulates protein synthesis and proliferation of C2C12 myoblast cells through the PI3K-ARID4B-mTOR pathway

Br J Nutr.

doi: 10.1017/S0007114521004918.

1472. Bingke Ma, Xingyue Shan, Juehua Yu, Tailin Zhu, Ren Li, Hui Lv, Haidi Cheng, Tiantian Zhang, Lihua Wang, Feiyang Wei, Bo Meng, Xiaobing Yuan, Bing Mei, Xiao-Yong Zhang, Wei-Guang Li, Fei Li

Social deficits via dysregulated Rac1-dependent excitability control of prefrontal cortical neurons and increased GABA/glutamate ratios

Cell Rep.

doi: 10.1016/j.celrep.2022.111722.

(IF 8.109)

1473. Raoqiong Wang, Mengnan Liu, Guilin Ren, Gang Luo, Zhichuan Wang, Zhengxin Ge, Qingrong Pu, Wei Ren, Sijin Yang

Zhilong Huoxue Tongyu Capsules' Effects on ischemic stroke: An assessment using fecal 16S rRNA gene sequencing and untargeted serum metabolomics

Front Pharmacol.

doi: 10.3389/fphar.2022.1052110.

(IF 4.225)

1474. Can Yang, Zhiyuan Feng, Hong Deng, Lu Dai, Ling He, Linlin Yin, Jing Zhao

CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut-brain axis

BMC Neurosci.

doi: 10.1186/s12868-022-00749-1.

(IF 2.811)

1475. Xue-Ting Li, Jia-Wei Song, Zhen-Zhou Zhang, Mi-Wen Zhang, Li-Rong Liang, Ran Miao, Ying Liu, Yi-Hang Chen, Xiao-Yan Liu, Jiu-Chang Zhong

Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling

Free Radic Biol Med.

doi: 10.1016/j.freeradbiomed.2022.10.320.

1476. Dongyan Zhang, Hong Zhu, Xin Yu, Liyin Wang, Yingying Wen, Liyue Zhang, Jianping Tong, Ye Shen

Blue light attenuates TGF-β2-induced epithelial-mesenchymal transition in human lens epithelial cells via autophagy impairment

BMC Ophthalmol.

doi: 10.1186/s12886-022-02691-6.

(IF 1.413)

1477. Yingchun Wang, Yuzhen Wang, Lu Ding, Xiaolei Ren, Bo Wang, Liyuan Wang, Songbo Zhao, Xuetian Yue, Zhuanchang Wu, Chunyang Li, Xiaohong Liang, Chunhong Ma, Lifen Gao

Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages

Cell Rep.

doi: 10.1016/j.celrep.2022.111738.

(IF 8.109)

1478. Zhuo Zhang, Xu Zhang, Xin Wu, Yan Zhang, Jie Lu, Dan Li

Sirt1 attenuates astrocyte activation via modulating Dnajb1 and chaperone-mediated autophagy after closed head injury

Cereb Cortex.

doi: 10.1093/cercor/bhac007.

(IF 5.043)

1479. Haoyu Guo, Lutong Wang, Wei Wu, Mingke Guo, Lingkai Yang, Zhenhao Zhang, Li Cao, Feifei Pu, Xin Huang, Zengwu Shao

Engineered biomimetic nanoreactor for synergistic photodynamic-chemotherapy against hypoxic tumor

J Control Release.

doi: 10.1016/j.jconrel.2022.09.020.

(IF 7.727)

1480. Ling Li, Yu Bai, Runyu Du, Lei Tang, Ling Li

Orphan nuclear receptor NUR77 relieves insulin resistance in HTR-8/SVneo trophoblast cells through activation of autophagy and insulin signaling

J Physiol Biochem.

doi: 10.1007/s13105-022-00901-9.

(IF 2.952)

1481. Tong Pei, Guanyue Su, Jie Yang, Wenbo Gao, Xinrui Yang, Yaojia Zhang, Jie Ren, Yang Shen, Xiaoheng Liu

Fluid Shear Stress Regulates Osteogenic Differentiation via AnnexinA6-Mediated Autophagy in MC3T3-E1 Cells

Int J Mol Sci.

doi: 10.3390/ijms232415702.

(IF 4.556)

1482. Hong Wang, Yingzhen Lai, Zeyu Xie, Yanyin Lin, Yihuang Cai, Zhiqiang Xu, Jiang Chen

Graphene Oxide-Modified Concentric Microgrooved Titanium Surfaces for the Dual Effects of Osteogenesis and Antiosteoclastogenesis

ACS Appl Mater Interfaces.

doi: 10.1021/acsami.2c14271.

1483. Yanru Chen, Wei Wang, Lingyu Fang, Zhenyang Zhang, Shishan Deng

Identification of PTK2 as an adverse prognostic biomarker in breast cancer by integrated bioinformatics and experimental analyses

Front Mol Biosci.

doi: 10.3389/fmolb.2022.984564.

(IF 4.188)

1484. Panpan Yang, Congshan Li, Qin Zhou, Xiaoqi Zhang, Yuying Kou, Qiushi Feng, He Wang, Rongjian Su, Tomoka Hasegawa, Hongrui Liu, Minqi Li

Notum leads to potential pro-survival of OSCC through crosstalk between Shh and Wnt/β-catenin signaling via p-GSK3β

Int J Biochem Cell Biol.

doi: 10.1016/j.biocel.2022.106316.

1485. Shenghan Su, Qingrui Zhao, Lingfeng Dan, Yuqing Lin, Xuebei Li, Yunjin Zhang, Chunxiao Yang, Yimeng Dong, Xiaohan Li, Romano Regazzi, Changhao Sun, Xia Chu, Huimin Lu

Inhibition of miR-146a-5p and miR-8114 in Insulin-Secreting Cells Contributes to the Protection of Melatonin against Stearic Acid-Induced Cellular Senescence by Targeting Mafa

Endocrinol Metab (Seoul).

doi: 10.3803/EnM.2022.1565.

1486. Jiajia Xu, Yangyang Li, Huan Zhu, Wenyu Wu, Yumeng Liu, Yu Guo, Weijun Guan, Changqing Liu, Caiyun Ma

Therapeutic function of a novel rat induced pluripotent stem cell line in a 6‑OHDA‑induced rat model of Parkinson's disease

Int J Mol Med.

doi: 10.3892/ijmm.2022.5196.

(IF 3.098)

1487. Liqun Wang, Wentao Zhang, Ruiyan Cen, Chenda Yue, Tianzhen Xiao, Yumeng Deng, Lingfei Li, Kedai Sun, Xia Lei

ALA-PDT regulates macrophage M1 polarization via ERK/MAPK-NLRP3 pathway to promote the early inflammatory response

Lasers Surg Med.

doi: 10.1002/lsm.23618.

1488. Kun Wang, Muyun Wang, Ximing Liao, Shaoyong Gao, Jing Hua, Xiaodong Wu, Qian Guo, Wujian Xu, Jiaxing Sun, Yanan He, Qiang Li, Wei Gao

Locally organised and activated Fth1hi neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner

Nat Commun.

doi: 10.1038/s41467-022-35492-y.

(IF 12.121)

1489. Yan-Ting Wu, Li-Shan Zhong, Chen Huang, Yu-Ying Guo, Fu-Jun Jin, Yu-Ze Hu, Zi-Bo Zhao, Zhe Ren, Yi-Fei Wang

β-Caryophyllene Acts as a Ferroptosis Inhibitor to Ameliorate Experimental Colitis

Int J Mol Sci.

doi: 10.3390/ijms232416055.

(IF 4.556)

1490. Xiaowei Song, Wenyan Cao, Zexu Wang, Feng Li, Ji Xiao, Qiongzhen Zeng, Yuan Wang, Shan Li, Cuifang Ye, Yifei Wang, Kai Zheng

Nicotinamide n-Oxide Attenuates HSV-1-Induced Microglial Inflammation through Sirtuin-1/NF-κB Signaling

Int J Mol Sci.

doi: 10.3390/ijms232416085.

(IF 4.556)

1491. Haijuan Bao, Wu Wu, Ying Li, Zhihong Zong, Shuo Chen

WNT6 participates in the occurrence and development of ovarian cancer by upregulating/activating the typical Wnt pathway and Notch1 signaling pathway

Gene.

doi: 10.1016/j.gene.2022.146871.

(IF 2.984)

1492. Wei Wu, Haoyu Guo, Doudou Jing, Zhenhao Zhang, Zhicai Zhang, Feifei Pu, Wenbo Yang, Xin Jin, Xin Huang, Zengwu Shao

Targeted Delivery of PD-L1-Derived Phosphorylation-Mimicking Peptides by Engineered Biomimetic Nanovesicles to Enhance Osteosarcoma Treatment

Adv Healthc Mater.

doi: 10.1002/adhm.202200955.

(IF 7.367)

1493. Jilong Zhou, Hainan He, Jing-Jing Zhang, Xin Liu, Wang Yao, Chengyu Li, Tian Xu, Shu-Yuan Yin, Dan-Ya Wu, Cheng-Li Dou, Qiao Li, Jiani Xiang, Wen-Jing Xiong, Li-Yan Wang, Jun-Ming Tang, Zhouyiyuan Xue, Xia Zhang, Yi-Liang Miao

ATG7-mediated autophagy facilitates embryonic stem cell exit from naive pluripotency and marks commitment to differentiation

Autophagy.

doi: 10.1080/15548627.2022.2055285.

(IF 9.77)

1494. Dan-Lin Zheng, Qing-Rui Wu, Peng Zeng, Sui-Min Li, Yong-Jiang Cai, Shu-Zhen Chen, Xue-Shan Luo, Su-Juan Kuang, Fang Rao, Ying-Yu Lai, Meng-Yuan Zhou, Fei-Long Wu, Hui Yang, Chun-Yu Deng

Advanced glycation end products induce senescence of atrial myocytes and increase susceptibility of atrial fibrillation in diabetic mice

Aging Cell.

doi: 10.1111/acel.13734.

(IF 7.238)

1495. Mengdi Gao, Xue Li, Mao Yang, WanRu Feng, Yan Lin, Tao He

TNFAIP3 mediates FGFR1 activation-induced breast cancer angiogenesis by promoting VEGFA expression and secretion

Clin Transl Oncol.

doi: 10.1007/s12094-022-02918-4.

(IF 2.737)

1496. Yi Wen, Lingxiu Fan, Lili Pang, Tingting Zhao, Ruonan Li, Ying Zhang, Liye Zhang, Wei Yang

NeiyiKangfu tablets control the progression of endometriosis through inhibiting RAF/MEK/ERK signal pathway by targeting RKIP

Gynecol Endocrinol.

doi: 10.1080/09513590.2022.2162495.

(IF 1.571)

1497. Li L, Xiao L, Hou Y, He Q, Zhu J, Li Y, Wu J, Zhao J, Yu S, Zhao Y.

Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing MitochondrialBiogenesis through the AMPK/PGC-1α Pathway in Rats.

1498. Jianguo Ai, Feng Zhao, Xiaowen Zhou

HMGA1 Aggravates Oxidative Stress Injury and Inflammatory Responses in IL-1β-Induced Primary Chondrocytes through the JMJD3/ZEB1 Axis

Int Arch Allergy Immunol.

doi: 10.1159/000526680.

1499. Lichun Guan, Ziqin Yu, Zhimei Che, Hang Zhang, Yong Yu, Dicheng Yang, Dewei Qian, Ruizhen Chen, Min Yu

Experimental diabetes exacerbates autophagic flux impairment during myocardial I/R injury through calpain-mediated cleavage of Atg5/LAMP2

J Cell Mol Med.

doi: 10.1111/jcmm.17642.

(IF 4.486)

1500. Yulin Huang, Jing Hao, Xuli Yang, Li Xu, Yue Liu, Yu'e Sun, Xiaoping Gu, Wei Zhang, Zhengliang Ma

Pretreatment of the ROS Inhibitor Phenyl-N-tert-butylnitrone Alleviates Sleep Deprivation-Induced Hyperalgesia by Suppressing Microglia Activation and NLRP3 Inflammasome Activity in the Spinal Dorsal

Neurochem Res.

doi: 10.1007/s11064-022-03751-5.

(IF 3.038)

1501. Mei Wang, Yingying Guo, Meiyin Wan, Zheng Chen, Julia Li Zhong

TAZ Reduces UVA-mediated Photoaging through Regulates Cell Proliferation in Skin Fibroblasts

Photochem Photobiol.

doi: 10.1111/php.13654.

(IF 2.721)

1502. Lijun Ling, Anqi Ren, Yan Lu, Yunyi Zhang, Haiyan Zhu, Peng Tu, Hong Li, Daofeng Chen

The synergistic effect and mechanisms of flavonoids and polysaccharides from Houttuynia cordata on H1N1-induced pneumonia in mice

J Ethnopharmacol.

doi: 10.1016/j.jep.2022.115761.

(IF 3.69)

1503. Denghui Shi, Wei Su, Yingchun Mu

Quantitative proteomics study on the changes of egg white of yellow preserved primary chicken eggs soaked in alkali solution

Food Res Int.

doi: 10.1016/j.foodres.2022.112346.

(IF 4.972)

1504. Jian Chai, Yongqiang Lei, Xindong Xiang, Jing Ye, Hang Zhao, Lili Yi

High expression of caspase-8 as a predictive factor of poor prognosis in patients with esophageal cancer

Cancer Med.

doi: 10.1002/cam4.5496.

1505. Chuansheng Yang, Meijiao Wang, Renfeng Huang, Linyang Ou, Min Li, Wanming Wu, Ruiwen Lei

Circ_0108942 Regulates the Progression of Breast Cancer by Regulating the MiR-1178-3p/TMED3 Axis

Clin Breast Cancer.

doi: 10.1016/j.clbc.2022.12.014.

(IF 2.647)

1506. Chang-Feng Song, Yu-Heng Hu, Zhi-Guo Mang, Zeng Ye, Hai-di Chen, De-Sheng Jing, Gui-Xiong Fan, Shun-Rong Ji, Xian-Jun Yu, Xiao-Wu Xu, Yi Qin

Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway

Acta Pharmacol Sin.

doi: 10.1038/s41401-022-01006-1.

(IF 5.064)

1507. Wei Wang, Yuqing Xiong, Haomiao Zhao, Rongli Xu

CircEXOC5 facilitates cell pyroptosis via epigenetic suppression of Nrf2 in septic acute lung injury

Mol Cell Biochem.

doi: 10.1007/s11010-022-04521-1.

(IF 2.795)

1508. Hongyan Liao, Jiagui Huang, Jie Liu, Huimin Zhu, Yue Chen, Xuemei Li, Jun Wen, Qin Yang

Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway

Mol Biol Rep.

doi: 10.1007/s11033-022-08167-6.

(IF 1.402)

1509. Xiao Lin, Zidi Jin, Shuo Li, Mingde Zheng, Ya Xing, Xikui Liu, Mengqing Lv, Minmeng Zhao, Tuoyu Geng, Daoqing Gong, Debiao Zhao, Long Liu

Preliminary Study on Expression and Function of the Chicken W Chromosome Gene MIER3 in Embryonic Gonads

Int J Mol Sci.

doi: 10.3390/ijms24108891.

(IF 4.556)

1510. L Xu, J Han, Z Yang, Y Yang, J Chen, X Wu, Q Wang, Y Hong

[LRG1 inhibits hepatic macrophage activation by enhancing TGF-β1 signaling to alleviate MAFLD in mice]

Nan Fang Yi Ke Da Xue Xue Bao.

doi: 10.12122/j.issn.1673-4254.2023.07.13.

1511. Li-Ping Shen, Wei Li, Ling-Zhu Pei, Jun Yin, Shu-Tao Xie, Hong-Zhao Li, Chao Yan, Jian-Jun Wang, Qipeng Zhang, Xiao-Yang Zhang, Jing-Ning Zhu

Oxytocin Receptor in Cerebellar Purkinje Cells Does Not Engage in Autism-Related Behaviors

Cerebellum.

doi: 10.1007/s12311-022-01466-5.

(IF 3.129)

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BCA法蛋白含量检测试剂盒 - 知乎切换模式写文章登录/注册BCA法蛋白含量检测试剂盒北京盒子生工科技有限公司​已认证账号【Boxbio】BCA法蛋白含量检测试剂盒(货号:AKPR017)BCA(Bicinchonininc Acid)蛋白含量检测法是用于总蛋白质定量的常用方法,BCA与二价铜离子混合即为BCA工作液,蛋白在碱性条件下能够将Cu²⁺还原为Cu⁺,Cu⁺与BCA试剂可形成紫色络合物,产物在562 nm处具有特征吸收峰,通过吸光值变化即可定量检测样品的蛋白浓度。名称试剂规格储存条件BCA Solution液体120 mL×1瓶RTCopper Solution液体3 mL×1瓶RTPBS Diluent液体30 mL×1瓶RTBSA Standard Solution (5 mg/mL BSA)液体1 mL×1支-20℃保存 (使用前恢复至室温)产品使用说明1.分光光度计法①样品稀释:将样品按适当倍数稀释,建议多做几个梯度进行检测(可参考进行2、4、8倍稀释);② BCA工作液的制备:根据使用量按BCA Solution:Copper Solution = 50:1(V:V)配制为BCA工作液,充分混匀(可能会有浑浊,充分混匀后即可溶解),BCA工作液室温保存24 h内有效;③蛋白标准稀释液的制备:取100 μL BSA Standard Solution使用PBS Diluent稀释至1000 μL(稀释液应与待测蛋白样品溶液一致,也可参考使用生理盐水作为稀释液),即为0.5 mg/mL蛋白标准稀释液。使用0.5 mg/mL蛋白标准稀释液,按下表进行梯度稀释:编号123456蛋白标准稀释液(μL)04080120160200PBS Diluent(μL)20016012080400蛋白终浓度(mg/mL)00.10.20.30.40.5④在离心管中依次加入下列试剂:试剂测定管 (μL)标准管 (μL)稀释样品100-蛋白标准稀释液-100BCA工作液10001000充分均匀,37℃显色15-30 min吸光值测定:测定562 nm处测定管和标准管吸光值,记为A测定和A标准。标准曲线的制备及使用:以0、0.1、0.2、0.3、0.4、0.5 mg/mL为横坐标(x),对应的A标准为纵坐标(y),得到线性回归方程y=kx+b,将A测定带入公式中计算x(mg/mL),乘以相应稀释倍数即为样品蛋白浓度。 2.酶标仪法①样品稀释:将样品按适当倍数稀释,建议多做几个梯度进行检测(可参考进行2、4、8倍稀释);② BCA工作液的制备:根据使用量按BCA Solution:Copper Solution = 50:1(V:V)配制为BCA工作液,充分混匀(可能会有浑浊,充分混匀后即可溶解),BCA工作液室温保存24 h内有效;③蛋白标准稀释液的制备:取10 μL BSA Standard Solution使用PBS Diluent稀释至100 μL(稀释液应与待测蛋白样品溶液一致,也可参考使用生理盐水作为稀释液),即为0.5 mg/mL蛋白标准稀释液。使用0.5 mg/mL蛋白标准稀释液,按下表进行梯度稀释:编号12345678蛋白标准稀释液(μL)02468121620PBS Diluent(μL)2018161412840蛋白终浓度(mg/mL)00.050.100.150.200.300.400.50④在96孔板中依次加入下列试剂:试剂测定管 (μL)标准管 (μL)稀释样本20-蛋白标准稀释液-20BCA工作液200200充分均匀,37℃显色15-30 min吸光值测定:测定562 nm处测定管和标准管吸光值,记为A测定和A标准。标准曲线的制备及使用:以0、0.05、0.1、0.15、0.2、0.3、0.4、0.5 mg/mL为横坐标(x),对应的A标准为纵坐标(y),得到线性回归方程y=kx+b,将A测定带入公式中计算x(mg/mL)。注意事项①Copper Solution与PBS Diluent可置于2-8℃长期保存,若发现污染浑浊则应丢弃;BCA Solution在低温条件下出现结晶沉淀时,可37℃温育使其完全溶解,不影响使用;②为了您的安全和健康,请穿实验服并戴一次性手套操作;③BCA法测定蛋白含量不受绝大部分样品中化学物质的影响,样品中5% SDS、5% Triton X-100、5% Tween20、60、80等常用浓度去垢剂不影响检测结果,但EDTA和EGTA等螯合剂、DTT和巯基乙醇等还原剂和脂类会影响检测结果,需确保EDTA低于10 mM、无EGTA、二硫苏糖醇低于1 mM、巯基乙醇低于0.01%;若样品含有较多干扰物质且本身背景值较高,建议使用Bradford法蛋白含量检测试剂盒(Cat AKPR015);④若蛋白浓度较低时(小于50 μg/mL),可将显色温度提高至60℃且待测样本与工作液比例调整为1:8进行测定,能够明显提高灵敏度至5 μg/mL;⑤为保证结果准确且避免试剂损失,测定前请仔细阅读说明书(以实际收到说明书内容为准),确认试剂储存和准备是否充分,操作步骤是否清楚,且务必取2-3个预期差异较大的样本进行预测定,过程中问题请您及时与工作人员联系。For Research Use Only. Not for Use in Diagnostic Procedures.编辑于 2021-12-13 14:01试剂生物化学分子生物学​赞同 8​​添加评论​分享​喜欢​收藏​申请

BCA蛋白浓度测定试剂盒

BCA蛋白浓度测定试剂盒

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BCA蛋白浓度测定试剂盒

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BCA蛋白浓度测定试剂盒

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货号:BL521A

规格:500T

品牌:Biosharp

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BCA蛋白浓度测定试剂盒产品简介:BCA蛋白浓度测定试剂盒的原理是蛋白质分子中肽键结构在碱性环境下能与Cu2+生产络合物,并将Cu2+还原成Cu+,而BCA试剂可以特异性地与Cu+结合,形成稳定的有颜色的复合物,并在562nm处有最大的光吸收值,该复合物颜色的深浅与蛋白质浓度成正比,可以根据吸收值的大小来测定蛋白的含量。使用说明:BCA工作液配制:将试剂A和试剂B按照体积比50:1比例混合,配成BCA工作液。如,取50ml 试剂A与1ml试剂B混合,配成51 ml BCA工作液。两者混合时会有沉淀形成,彻底混匀后沉淀消失,现配现用。微孔板测定程序:(工作范围50-2000 μg/ml)1、蛋白标准品配制:室温完全溶解蛋白标准品,取20µl 5mg/ml BSA蛋白标准溶液用PBS溶液稀释至100µl,使其终浓度为1.0 mg/ml。       2、配制BSA标准测定溶液 。 3、将适当体积的待测样品加入到微孔板中,并用PBS补足到20 µl4、向微孔板中加入200 μl BCA工作液,混匀,37℃放置30分钟;注:也可以室温放置2小时,或60℃放置30分钟。BCA法测定蛋白浓度时,颜色会随着时间的延长不断加深,并且显色反应会因温度升高而加快。如果浓度较低,适合在较高温度孵育,或适当延长孵育时间。5、测定562 nm 处的吸光值,并记录读数;以不含BSA 的样品的光吸收值作为空白对照。6、以A562为纵坐标,BSA含量为横坐标,绘制标准曲线,计算样品中的蛋白浓度。如果所得到的蛋白浓度不在标准曲线范围内,请稀释样品后重新测定。试管测定程序:(工作范围50-1000 μg/ml)1、蛋白标准品配制:室温完全溶解蛋白标准品,取150µl 5mg/ml BSA蛋白标准溶液,加入600μl PBS溶液稀释至750µl,使其终浓度为1.0 mg/ml。       2、配制BSA标准测定溶液。3、将适当体积的待测样品加入到试管中,并用PBS补足到100 µl;4、向试管中加入2ml BCA工作液,混匀,37℃放置30分钟;5、6步骤同上。产品特点:1、灵敏度高,检测浓度下限达到25µg/ml(在50-1000μg/ml浓度范围内有较好的线性关系),最小检测蛋白量达到0.5μg,待测样品体积为1-20μl。2、BCA法测定蛋白浓度的最大优点是蛋白浓度的测定可以耐受高浓度的去垢剂,可以兼容样品中高达5%的SDS,5%的Triton X-100,5%的Tween 20, 60, 80。但受螯合剂和略高浓度的还原剂的影响,需确保EDTA低于10mM,无EGTA,二硫苏糖醇低于1mM,β-巯基乙醇低于0.01%。 3、为了您的安全和健康,请穿实验服并戴一次性手套操作。保存条件:试剂A和试剂B室温贮存;牛血清白蛋白标准溶液-20℃贮存;PBS溶液4℃贮存。本试剂盒有效期1年。

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Pierce™ BCA Protein Assay Kits

Pierce™ BCA Protein Assay Kits

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HomeShop All ProductsProtein Analysis ReagentsProtein AssaysTotal Protein Assay KitsPierce™ BCA Protein Assay KitsThermo Scientific™Pierce™ BCA Protein Assay KitsCatalog number: 23227Related applications: Protein Assays & AnalysisTechnical SupportCustomer ServiceThermo Scientific™Pierce™ BCA Protein Assay KitsCatalog number: 23227Related applications: Protein Assays & AnalysisTechnical SupportCustomer ServiceThe Pierce BCA Protein Assay Kit is a high-precision, detergent-compatible protein assay for determination of protein concentration. Pierce BCA reagents provide accurate determination of protein concentration with most sample types encountered in protein research. The Pierce BCA assay can be used to assess yields in whole cell lysates, affinity-column fractions, purified proteins samples, as well as to monitor protein contamination in industrial applications. Compared to most dye-binding methods, the BCA assay is affected much less by protein compositional differences, providing greater concentration accuracy.Kits are available with or without Pierce Dilution-Free BSA Protein Standards, which are a set of seven pre-diluted BSA standards, packaged in a multichannel pipette-friendly tubestrip. The tubestrip includes a single empty tube that enables users to add their own sample buffer for the purpose of blank subtraction. Catalog Number23227Unit Size500 mLDescriptionPierce BCA Protein Assay Kit, 500 mLConcentrationBSA: 2 mg/mLKit Contents10 x 1 mL glass ampulesPrice (USD)Contact Us ›Availability***Full specificationsQuantity-ConcentrationBSA: 2 mg/mLDescriptionPierce BCA Protein Assay Kit, 500 mLAssayBCA AssayDetection MethodColorimetricProduct LinePierce™Product TypeProtein Quantitation AssaySpecificityNot Target-SpecificSufficient For250 Tube Assays or 2500 Microplate AssaysFor Use With (Application)Solution-based Detection, AbsorbanceFor Use With (Equipment)Spectrophotometer, Microplate ReaderKit Contents10 x 1 mL glass ampulesQuantity1 Kit (500 mL)Unit Size500 mLSave to listCatalog Number23225Unit Size1 LDescriptionPierce BCA Protein Assay Kit, 1000 mL ConcentrationBSA: 2 mg/mLKit Contents10 x 1 mL glass ampulesPrice (USD)Contact Us ›Availability***Full specificationsQuantity-ConcentrationBSA: 2 mg/mLDescriptionPierce BCA Protein Assay Kit, 1000 mL AssayBCA AssayDetection MethodColorimetricProduct LinePierce™Product TypeProtein Quantitation AssaySpecificityNot Target-SpecificSufficient For500 Tube Assays or 5000 Microplate AssaysFor Use With (Application)Solution-based Detection, AbsorbanceFor Use With (Equipment)Spectrophotometer, Microplate ReaderKit Contents10 x 1 mL glass ampulesQuantity1 Kit (1 L)Unit Size1 LSave to listCatalog NumberA55864Unit Size1 LDescriptionPierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsConcentrationBSA: 0.125, 0.25, 0.5, 0.75, 1, 1.5, and 2 mg/mLKit Contents4 x 1 mL 8-channel tubestrip, predilutedPrice (USD)Price: 366.00Your price: Sign InAvailability***Full specificationsQuantityConcentrationBSA: 0.125, 0.25, 0.5, 0.75, 1, 1.5, and 2 mg/mLDescriptionPierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsAssayBCA AssayDetection MethodColorimetricProduct LinePierce™Product TypeProtein Quantitation AssaySpecificityNot Target-specificSufficient For500 Tube Assays or 5000 Microplate AssaysFor Use With (Application)Solution-based Detection, AbsorbanceFor Use With (Equipment)Spectrophotometer, Microplate ReaderKit Contents4 x 1 mL 8-channel tubestrip, predilutedQuantity1 Kit (1 L)Unit Size1 LSave to listAdd to cartCatalog NumberA55865Unit Size500 mLDescriptionPierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsConcentrationBSA: 0.125, 0.25, 0.5, 0.75, 1, 1.5, and 2 mg/mLKit Contents2 x 1 mL 8-channel tubestrip, predilutedPrice (USD)Price: 258.00Your price: Sign InAvailability***Full specificationsQuantityConcentrationBSA: 0.125, 0.25, 0.5, 0.75, 1, 1.5, and 2 mg/mLDescriptionPierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsAssayBCA AssayDetection MethodColorimetricProduct LinePierce™Product TypeProtein Quantitation AssaySpecificityNot Target-specificSufficient For250 Tube Assays or 2500 Microplate AssaysFor Use With (Application)Solution-based Detection, AbsorbanceFor Use With (Equipment)Spectrophotometer, Microplate ReaderKit Contents2 x 1 mL 8-channel tubestrip, predilutedQuantity1 Kit (500 mL)Unit Size500 mLSave to listAdd to cartShowing 4 of 4Catalog NumberSpecificationsUnit SizeDescriptionConcentrationKit ContentsPrice (USD)AvailabilityQuantity23227Full specifications500 mLPierce BCA Protein Assay Kit, 500 mLBSA: 2 mg/mL10 x 1 mL glass ampulesContact Us ›***-ConcentrationBSA: 2 mg/mLDescriptionPierce BCA Protein Assay Kit, 500 mLAssayBCA AssayDetection MethodColorimetricProduct LinePierce™Product TypeProtein Quantitation AssaySpecificityNot Target-SpecificSufficient For250 Tube Assays or 2500 Microplate AssaysFor Use With (Application)Solution-based Detection, AbsorbanceFor Use With (Equipment)Spectrophotometer, Microplate ReaderKit Contents10 x 1 mL glass ampulesQuantity1 Kit (500 mL)Unit Size500 mL23225Full specifications1 LPierce BCA Protein Assay Kit, 1000 mL BSA: 2 mg/mL10 x 1 mL glass ampulesContact Us ›***-ConcentrationBSA: 2 mg/mLDescriptionPierce BCA Protein Assay Kit, 1000 mL AssayBCA AssayDetection MethodColorimetricProduct LinePierce™Product TypeProtein Quantitation AssaySpecificityNot Target-SpecificSufficient For500 Tube Assays or 5000 Microplate AssaysFor Use With (Application)Solution-based Detection, AbsorbanceFor Use With (Equipment)Spectrophotometer, Microplate ReaderKit Contents10 x 1 mL glass ampulesQuantity1 Kit (1 L)Unit Size1 LA55864Full specifications1 LPierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsBSA: 0.125, 0.25, 0.5, 0.75, 1, 1.5, and 2 mg/mL4 x 1 mL 8-channel tubestrip, predilutedPrice: 366.00Your price: Sign In***ConcentrationBSA: 0.125, 0.25, 0.5, 0.75, 1, 1.5, and 2 mg/mLDescriptionPierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsAssayBCA AssayDetection MethodColorimetricProduct LinePierce™Product TypeProtein Quantitation AssaySpecificityNot Target-specificSufficient For500 Tube Assays or 5000 Microplate AssaysFor Use With (Application)Solution-based Detection, AbsorbanceFor Use With (Equipment)Spectrophotometer, Microplate ReaderKit Contents4 x 1 mL 8-channel tubestrip, predilutedQuantity1 Kit (1 L)Unit Size1 LA55865Full specifications500 mLPierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsBSA: 0.125, 0.25, 0.5, 0.75, 1, 1.5, and 2 mg/mL2 x 1 mL 8-channel tubestrip, predilutedPrice: 258.00Your price: Sign In***ConcentrationBSA: 0.125, 0.25, 0.5, 0.75, 1, 1.5, and 2 mg/mLDescriptionPierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsAssayBCA AssayDetection MethodColorimetricProduct LinePierce™Product TypeProtein Quantitation AssaySpecificityNot Target-specificSufficient For250 Tube Assays or 2500 Microplate AssaysFor Use With (Application)Solution-based Detection, AbsorbanceFor Use With (Equipment)Spectrophotometer, Microplate ReaderKit Contents2 x 1 mL 8-channel tubestrip, predilutedQuantity1 Kit (500 mL)Unit Size500 mLShowing 4 of 4Save to listAdd to cartRequest bulk or custom quoteThe Pierce BCA Protein Assay Kit is a high-precision, detergent-compatible protein assay for determination of protein concentration. Pierce BCA reagents provide accurate determination of protein concentration with most sample types encountered in protein research. The Pierce BCA assay can be used to assess yields in whole cell lysates, affinity-column fractions, purified proteins samples, as well as to monitor protein contamination in industrial applications. Compared to most dye-binding methods, the BCA assay is affected much less by protein compositional differences, providing greater concentration accuracy.Kit options are available that include Pierce Dilution-Free BSA Protein Standards, which are a set of seven pre-diluted BSA standards, packaged in a multichannel pipette-friendly tubestrip.  The tubestrip includes a single empty tube that enables users to add their own sample buffer for the purpose of blank subtraction.Features of the BCA Protein Assay Kit include: • Colorimetric—estimate visually or measure with a standard spectrophotometer or plate reader at 562 nm • Accurate—exhibits half the protein-to-protein variation observed with dye-binding methods (Bradford) • Compatible—unaffected by typical concentrations of most ionic and non-ionic detergents • Short assay time—30-min incubation; much easier and four times faster than classical Lowry methods • Wide assay range—linear working range for BSA of 20 to 2000 μg/mL • Sensitive—detect down to 5 μg/mL with enhanced protocol• No more serial dilutions—kit options include Dilution-Free BSA Protein Standards which eliminate the need to perform serial dilutions when generating a standard curveHow the assay works The BCA Protein Assay combines the well-known reduction of Cu2+ to Cu1+ by protein in an alkaline medium with the highly sensitive and selective colorimetric detection of the cuprous cation (Cu1+) by bicinchoninic acid (BCA). The first step is the chelation of copper with protein in an alkaline environment to form a light blue complex. In this reaction, known as the biuret reaction, peptides containing three or more amino acid residues form a colored chelate complex with cupric ions in an alkaline environment containing sodium potassium tartrate. In the second step of the color development reaction, BCA reacts with the reduced (cuprous) cation that was formed in step one. The intense purple-colored reaction product results from the chelation of two molecules of BCA with one cuprous ion. The BCA/copper complex is water soluble and exhibits a strong linear absorbance at 562 nm with increasing protein concentrations. The complex is approximately 100 times more sensitive (lower limit of detection) than the pale blue color of the first reaction. The reaction is strongly influenced by four amino acid residues (cysteine, cystine, tyrosine, and tryptophan) in the amino acid sequence of the protein. However, unlike Coomassie dye-binding methods (i.e., Bradford), the universal peptide backbone also contributes to color formation, helping to minimize variability caused by protein compositional differences.For Research Use Only.For Research Use Only. Not for use in diagnostic procedures.Contents & StorageSufficient For: 250 tube assays or 2500 microplate assays• BCA Reagent A, 500 mL• BCA Reagent B, 25 mL• Albumin Standard Ampules, 2 mg/mL, 10 x 1 mLStore at room temperatureFiguresDocuments & DownloadsCertificatesSearch by lot number or partial lot numberSearchRequest a CertificateFrequently asked questions (FAQs)Citations & ReferencesSearch citations by name, author, journal title or abstract textSearch

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发表文章 (13)

BCA蛋白浓度检测试剂盒

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Cat No : PK10026

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产品介绍Proteintech BCA蛋白浓度检测试剂盒是一种双组分、高精度、兼容去垢剂的蛋白定量试剂盒,可实现对蛋白质进行快速、稳定、灵敏的浓度测定。该定量的原理是在碱性环境下,蛋白质将 Cu2+还原成 Cu+的反应,然后使用含有BCA 的试剂,利用比色法来检测亚铜阳离子 (Cu+) ,形成一种在540-595 nm之间(最佳562 nm) 处有强吸收值的紫色复合物,通过与标准品曲线对比,获得待测定蛋白的浓度。对于蛋白研究中的常见样品类型如:全细胞裂解物、亲和柱分离组分和蛋白样品纯化的产物等,此款BCA蛋白浓度检测试剂盒可准确测定其蛋白浓度。与大多数染料结合法相比,BCA蛋白定量法受蛋白质氨基酸组成差异的影响更小,因此有更高的蛋白间定量一致性。关于试剂盒●本检测范围:蛋白质浓度的检测范围为 20 至 2000 ug/mL。●本产品可以采用分光光度计或酶标仪测定蛋白浓度。●使用96孔微孔板方案需要的待测蛋白样品体积10-25 uL。●测量500 ug/mL以下的蛋白浓度可将BSA标准品绘制25 ug/mL到500 ug/mL的标准曲线,能够进一步的提升检测精准度。●部分干扰BCA定量分析的物质包括还原剂、螯合剂、强酸或强碱等,即使浓度很低也可能会影响定量的结果(参考表2)。●对于浓度高于2000 ug/mL的待测蛋白样品,可根据样品的浓度,提前稀释 5 倍或 10 倍再进行检测。●Proteintech蛋白提取试剂盒产品提取的蛋白样品经过稀释后(使蛋白浓度在检测范围内)均可使用本BCA蛋白浓度检测试剂盒进行定量。

组分

规格(250T/500T)

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BCA试剂A液

50 mL/100 mL

室温保存一年

BCA试剂B液

1.5 mL/3 mL

室温保存一年

BSA标准品溶液(2 mg/mL)

1 mL*2/1 mL*3

室温保存一年

保存条件室温保存一年。

使用方法1. 蛋白标准品的准备用与待测蛋白样品一致的稀释液按表1梯度稀释牛血清白蛋白(BSA)标准品。表1 梯度稀释牛血清白蛋白(BSA)标准品管号稀释液的体积(uL)2 mg/mL BSA 标准品用量(uL)BSA 标准品最终浓度(ug/mL)A0

           200 uL原液2000B100300 uL原液1500C200200 uL原液1000D200200 uL B管稀释液750E200200 uL C管稀释液500F200200 uL E管稀释液250G200200 uL F管稀释液125H20050 uL G管稀释液25I20000(空白)2. 配制BCA工作液(1)计算所需BCA工作液总体积:所需BCA工作液总体积=(BSA 标准品样本个数+待测蛋白样本的个数)× 实验重复次数 × 用于每个样本的 BCA工作液体积。 注意:在96孔微孔板方案中,每个样本需要200 uL BCA工作液。(2)按所需BCA工作液总体积,将50份 BCA试剂A液与1份BCA试剂B液混合(BCA试剂A液与B液的比例=50:1),充分混匀。例如5 mL BCA试剂A液 与100 uL BCA试剂B液混匀,配制成5.1 mL BCA工作液。注意:当BCA试剂B液加入BCA试剂A液时,会观察到深绿色浑浊,经混匀浑浊会迅速消失,得到绿色澄清工作液。BCA工作液储存于密闭容器中,在室温下可稳定保存24小时。 3. 蛋白浓度检测(1)加入梯度稀释好的标准品和待测蛋白样品:将梯度稀释好的BSA标准品和待测蛋白样品各20 uL分别加入到做好标记的96孔微板孔中,推荐每个待测的样本做2-3个平行反应(根据样品的浓度,可提前稀释5-10倍使蛋白浓度在检测范围内)。(2)加入BCA工作液:每孔加入200 uL BCA工作液,震荡30 s,充分混匀,盖上96孔板盖,37 ℃孵育30 min。注意:延长孵育时间或升高温度可使检测下限降至20 ug/mL以下,但检测范围会缩小。(3)酶标仪读数:96孔微板孔冷却至室温,使用酶标仪测定562 nm或540-595 nm之间波长的吸光值。(4)绘制标准曲线,计算待测蛋白样品浓度:首先将每个标准品和待测蛋白样品的吸光值减去空白标准品的吸光值进行空白校正,然后将校正后的BSA标准品吸光值对其浓度(ug/mL)绘制标准曲线,最后使用该标准曲线计算每个待测蛋白样品的浓度。

注意1. 建议每次测定蛋白样品时,绘制标准曲线,获得更准确数据。2. BSA 标准品稀释液需和待测样品的稀释液一致。3. BCA 法测定蛋白浓度时,吸光值会随时间的延长不断加深,并且显色反应会因浓度升高而加快,如果浓度较低,适合较高温度孵育,或适当延长孵育时间。4. 如果得到的蛋白浓度不在检测范围内,请重新稀释样品后再次测定。5. 样品制备试剂盒产品提取的总蛋白通常浓度会较高,可提前稀释 5 -10 倍使蛋白浓度在检测范围内再进行BCA法蛋白定量。

问题解答1. 哪些物质会干扰BCA定量分析的结果?答: 各物质与BCA的兼容性浓度见表2,由表2可知干扰BCA定量分析的物质包括还原剂、螯合剂、强酸及强碱等,及浓度很低也可能会影响定量的结果。  表2 各物质与BCA的兼容性浓度物质

                          兼容性浓度

           物质

                          兼容性浓度

           BCA

           Bradford

           BCA

           Bradford        酸/碱

               溶剂

               HCl0.1 mol/L0.1 mol/LMDSO10%10%NaOH0.1 mol/L0.1 mol/L乙醇10%10%高氯酸<1%NA甘油10%10%三氯乙酸<1%NA盐酸胍4.0 mol/L3.5 mol/L缓冲液/盐类

               甲醇10%10%硫酸铵1.5 mol/L1.0 mol/LPMSF1 mmol/L1 mmol/L硼酸盐10 mmol/L不稀释蔗糖40%10%甘氨酸1 mmol/L100 mmol/L尿素3.0 mol/L3.0 mol/L咪唑100 mmol/L100 mmol/L去垢剂

               HEPES50 mmol/L200 mmol/LBrij355%0.125%氯化钾<10 mmol/L1.0 mol/LCHAPS5%5%PBS不稀释不稀释脱氧胆酸钠5%0.05%乙酸钠200 mmol/L180 mmol/LNP-405%0.5%叠氮钠0.20%0.50%SDS5%0.125%氯化钠1.0 mol/L5.0 mol/LTriton X-1005%0.125%三乙酸铵25 mmol/LNATween-205%0.062%Tris250 mmol/L2.0 mol/L螯合剂

               还原剂

               EDTA10 mmol/L100 mmol/L半胱氨酸NA10 mmol/LEGTANA2 mmol/LDTT1 mmol/L5-1000 mmol/L其他

           2-巯基乙醇0.01%1.0 mol/LDNA0.1 mg0.25 mg硫柳汞0.01%0.01%2. BCA法与Bradford法应如何选择?答:主要由样本中干扰物质的兼容性浓度决定(参考表2)。如果待测蛋白样品中含有大量去垢剂且不含螯合剂和还原剂时,可选用BCA法;如果待测蛋白样品中含有螯合剂和还原剂,且不含有去垢剂时,可使用Bradford法。3. Proteintech蛋白提取试剂盒产品提取的蛋白样品是否可以直接使用本BCA试剂盒蛋白定量?答:Proteintech蛋白提取试剂盒产品如:细胞总蛋白提取试剂盒(货号:PK10020)、动物组织总蛋白提取试剂盒(货号:PK10021)、线粒体分离及蛋白提取试剂盒(货号:PK10016)、核蛋白与胞浆蛋白抽提试剂盒(货号:PK10014)、膜蛋白抽提试剂盒(货号:PK10015)、组蛋白抽提试剂盒(货号:PK10022)、磷酸化蛋白提取试剂盒(货号:PK10023)、易降解蛋白提取试剂盒(货号:PK10024)、血清血浆白蛋白去除试剂盒(货号:PK10025)等提取的蛋白样品经过稀释后(使蛋白浓度在在检测范围内)均可使用本BCA蛋白浓度检测试剂盒进行定量。4. BCA法孵育时间和温度对检测结果有何影响?答: 96孔微孔板方案中,推荐的37℃孵育30 min。当延长孵育时间或升高温度对于低浓度待测样品(20-100 ug/mL)的蛋白定量会更加精准,但检测范围会缩小,高浓度(1000-2000 ug/mL)之间的蛋白定量精度会下降。5. BCA法待测样品加入的体积对检测结果有何影响?答:BCA法待测样品加入的体积范围为10-25 uL,推荐最佳待测样品体积为20 uL。对于低浓度待测样品(20-100 ug/mL)的蛋白定量推荐可加入待测样品体积25 uL;对于高浓度待测样品(500-2000 ug/mL)的蛋白定量推荐可适当减少待测样品体积,最低不少于10 uL。但必须保持待测蛋白样品和BSA标准品的用量体积一致。

PublicationsApplicationTitleFront PharmacolThe interaction of MD-2 with small molecules in huanglian jiedu decoction play a critical role in the treatment of sepsisAuthors - Guirong ChenView ArticleJ Pharm Biomed AnalIntegrated network pharmacology and metabolomics reveal the action mechanisms of vincristine combined with celastrol against colon cancerAuthors - Jin-Yu NingView ArticlePhysiol BehavExposure to melamine cyanuric acid in adult mice caused motor activity and skeletal muscle energy metabolism disorderAuthors - Sijie WangView ArticleBMC Mol Cell BiolRibosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathwayAuthors - Huahua ZhangView ArticleCurr Pharm DesMechanism of HSP90 Inhibitor in the Treatment of DSS-induced Colitis in Mice by Inhibiting MAPK Pathway and Synergistic Effect of Compound Sophora DecoctionAuthors - Yuyi YuanView ArticleBMC Mol Cell BiolRPL11 promotes non-small cell lung cancer cell proliferation by regulating endoplasmic reticulum stress and cell autophagyAuthors - Jie ChenView Article

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Micro BCA™ Protein Assay Kit

Micro BCA™ Protein Assay Kit

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HomeShop All ProductsProtein Analysis ReagentsProtein AssaysTotal Protein Assay KitsMicro BCA™ Protein Assay KitThermo Scientific™Micro BCA™ Protein Assay KitCatalog number: 23235Related applications: Protein Assays & AnalysisTechnical SupportCustomer ServiceThermo Scientific™Micro BCA™ Protein Assay KitCatalog number: 23235Related applications: Protein Assays & AnalysisTechnical SupportCustomer ServiceCatalog Number23235Unit Size500 mLPrice (USD)Contact Us ›Save to listCatalog NumberUnit SizePrice (USD)23235500 mLContact Us ›Save to listRequest bulk or custom quoteProduct OverviewFiguresVideosRecommendationsRecommendationsDocumentsFAQCitations & ReferencesAdditional InformationRecommendationsThe Pierce Micro BCA Protein Assay Kit is a three-component version of our BCA reagents, optimized to measure total protein concentration of dilute protein solutions (0.5 to 20 μg/mL).Compare all available BCA protein assays ›Features of the Micro BCA Protein Assay Kit include:• Sensitivity—accurately detect down to 0.5 μg/mL (2 μg/mL in microplate format)• Working range—linear working range for BSA of 0.5 to 20 μg/mL• Colorimetric—measure with a standard spectrophotometer or plate reader at 562 nm• Compatibility—unaffected by typical concentrations of most ionic and non-ionic detergents• Stability—kit is stable at room temperature; prepared working reagent stable for up to 24 hoursThe Micro BCA Protein Assay Kit is a specialized version of the popular Pierce BCA Protein Assay for determining the protein concentration of dilute samples. Mixing together the three Micro BCA reagents results in a working solution that is sufficiently concentrated to measure protein when mixed with an equal volume of sample. The result is an assay for accurately measuring 0.5 to 20 μg/mL protein solutions. The assay is exceptionally linear and exhibits very low levels of protein-to-protein variability.Related productsMicro BCA Reagent A (MA)Micro BCA Reagent B (MB)Micro BCA Reagent C (MC)Ampule BreakersFor Research Use Only. Not for use in diagnostic procedures.SpecificationsDescriptionPierce Micro BCA Protein Assay KitAssayBCA AssayDetection MethodColorimetricProduct LineMicro BCA™, Pierce™Product TypeProtein Quantitation AssaySpecificityNot Target-SpecificSufficient For480 Tube Assays or 3200 Microplate AssaysFor Use With (Application)Solution-based Detection, AbsorbanceFor Use With (Equipment)Spectrophotometer, Microplate ReaderQuantity500 mLContents & StorageSufficient For: 480 tube assays or 3200 microplate assays• Micro BCA Reagent A (MA), 240 mL• Micro BCA Reagent B (MB), 240 mL• Micro BCA Reagent C (MC), 12 mL• Albumin Standard Ampules, 2 mg/mL, 10 x 1 mLStore at room temperature.FiguresDocuments & DownloadsCertificatesSearch by lot number or partial lot numberSearchRequest a CertificateFrequently asked questions (FAQs)Citations & ReferencesSearch citations by name, author, journal title or abstract textSearch

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